{"id":"471882e3-51d2-49fd-87c1-53f98cf9c2e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:78b0cdd3-02b4-4f76-ba18-6c4efc0a0f3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:O60755"}
{"id":"86c37e0d-740a-485d-8706-ec02dead3a1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3840","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:17f0e549-fb38-4588-b371-9cc3b00eab8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3840","original_object":"UniProtKB:P30550"}
{"id":"da44811a-9914-4c01-8b92-b4b0078ada62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996540","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:4be40c8d-b803-4047-a15a-79d4a1979d19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10702","original_object":"UniProtKB:P48736"}
{"id":"3c9ebda2-ffd7-488f-851a-b9c430c8ed35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177616","predicate":"biolink:affects","object":"NCBIGene:193034","sources":[{"id":"urn:uuid:3c6c8c5a-3e2a-4f82-8082-45a3d66b31b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2488","original_object":"UniProtKB:Q704Y3"}
{"id":"dd616a2c-bbe4-4754-a7d9-cdf6ee8f0e8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132268","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:fbf20cb2-66ae-472b-91c6-1a0faa0614b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7422","original_object":"UniProtKB:P00533"}
{"id":"9850c7aa-4051-40fe-884e-68ed83e43c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:07ODS257BP","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:ec9f5fa7-dbf8-4c4c-9550-75e8b69f2fb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10416","original_object":"UniProtKB:P51679"}
{"id":"d38b0695-b159-45cd-854a-6e74790e4627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9584673","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:def72cbb-a7a8-41cc-b157-cacd2e141c46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4134","original_object":"UniProtKB:O75762"}
{"id":"37c17ed7-adbe-4a24-b218-f78478e77ddd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817479","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:b967cc65-3e4f-4cd4-87b2-70f706ec1427","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6083","original_object":"UniProtKB:O43603"}
{"id":"c0638338-fdb9-4d54-aac9-4b9fb503865c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28411","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:7dde7a0e-abd1-42e7-9df8-8986a920d5fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2419","original_object":"UniProtKB:Q8NER1"}
{"id":"34b1dfcd-a9cd-4968-b9c9-2b04b1350dc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63637","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:044e120f-f0df-4a48-87e3-8d5ad2f9175f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5893","original_object":"UniProtKB:P15056"}
{"id":"4a2f5340-4136-476f-af23-ba03a03493c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:0f01a20f-b8c5-49c9-98c4-d06444f88236","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08172"}
{"id":"8bd07fb3-9af1-4be3-99b1-52121268a95e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1326","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:a4ec8993-2895-4bdb-bf5d-82b3d68312c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1326","original_object":"UniProtKB:P41968"}
{"id":"228d3507-c307-40e7-8717-6fb31cca0c89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131839646","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:af430c76-7e8a-4f8f-b384-48ea09115619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12237","original_object":"UniProtKB:Q16620"}
{"id":"20588ae3-ecaf-4b41-95f2-f55ece1f9415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9844711","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:263d1584-78aa-4b5f-9a97-ab468a1b0af5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:746","original_object":"UniProtKB:O75311"}
{"id":"59de1af0-3a70-417d-b71a-eb80e99d1d87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:5de3fdec-bea5-4bac-a4e0-652606460495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P21728"}
{"id":"41f21ad6-de85-4d42-a413-e7eb0e6d6d1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:206077","predicate":"biolink:affects","object":"NCBIGene:1491","sources":[{"id":"urn:uuid:d23a90e3-17a4-4bce-8e64-593039c2cd07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8860","original_object":"UniProtKB:P32929"}
{"id":"990efbfe-0b0d-4b75-9a65-29adafcfdcc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5074","predicate":"biolink:affects","object":"NCBIGene:53883","sources":[{"id":"urn:uuid:2a83ebe8-6a90-45e2-ab18-0e177d28977c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5074","original_object":"UniProtKB:Q9R0M0"}
{"id":"e758e425-e5c8-4c75-b0dc-bdea6f36b296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:9a7bc654-d712-4fd0-8e63-afaf185c0e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q923J1"}
{"id":"fe35adcf-219f-472c-94e3-1e9619dfa962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50815","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:3b2fd5ab-86a8-4fc7-b599-ab86a3a5230f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7091","original_object":"UniProtKB:Q13507"}
{"id":"0c7cfc34-a475-4aca-b7f9-9c0b865ed3ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92375","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:8480e8ff-6b31-46fb-a2d2-524c0c4fabe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6041","original_object":"UniProtKB:Q9NYA1"}
{"id":"9d621bde-5d9c-4f09-834b-031e5f24a71d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:33d28068-f730-472d-8c75-5c22f0fc0458","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:P21555"}
{"id":"d97a7f90-6029-4740-b187-585aa8ee10b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6GVX9S46ZO","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ee64d859-36e2-4daa-95dc-fb77025f7267","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3242","original_object":"UniProtKB:P28223"}
{"id":"d593722a-ce9b-40f7-8b25-057800aeda03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8350","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:2ce151b1-fc09-439e-85e5-ac910e51fc39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8350","original_object":"UniProtKB:Q8TDU9"}
{"id":"73fe8a8b-d0fe-4e6b-a829-fc21c4fa9cd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803245","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:9197e2aa-8439-4285-8dfc-ac80463be844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:339","original_object":"UniProtKB:P08172"}
{"id":"58f95123-53ef-41fd-ac51-ea7f422b36cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:37750349","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:bdf9f097-96d8-4066-adb0-29cf7c6106df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9655","original_object":"UniProtKB:P49760"}
{"id":"28faa673-6b10-42a8-8eec-de93c6b1e569","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180961","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:8a8e41d5-9a67-46c0-b177-88ecbc375d0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2745","original_object":"UniProtKB:Q96RI1"}
{"id":"63c10ca8-2c2c-40e5-a3b6-71bbb10be117","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:bdca5c5f-9a76-49d6-ba5c-0f42471a6667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:O15379"}
{"id":"6992f261-79a5-449f-9620-077b9852f5f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10231401","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:02f58baf-76d2-4d43-a147-e1dc116a0c00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5584","original_object":"UniProtKB:P30968"}
{"id":"c893da88-bf04-440b-a23a-81ca0d822c33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2052828","predicate":"biolink:affects","object":"NCBIGene:50940","sources":[{"id":"urn:uuid:51b0a206-567c-45a9-a988-e8fdbdc2b7b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6559","original_object":"UniProtKB:Q9HCR9"}
{"id":"4f198f9a-2cdc-465d-8270-eaf1b77e965b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GA36S2O9C2","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:eb3ace2c-fdda-4533-9ef2-45a7a7c01797","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4245","original_object":"UniProtKB:P48058"}
{"id":"a91c67a3-506e-4638-8935-444c228d49ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221382","predicate":"biolink:affects","object":"NCBIGene:5550","sources":[{"id":"urn:uuid:289c28e7-dd27-4b54-bd11-131e554b3b3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10967","original_object":"UniProtKB:P48147"}
{"id":"d2db85dd-5be1-4951-a51d-61af68657173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:838dabbd-4c3c-4c6a-aa3d-054223d3f53d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P30936"}
{"id":"3cd4260c-2668-4b51-9ffe-73d4b7a4f636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93768","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:cef4d8cb-a5b6-4713-9b47-4c784259b0c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5683","original_object":"UniProtKB:Q9UM73"}
{"id":"54646b2c-be95-4c44-9743-3d628c5d377d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:47M5ZXU844","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:cda635d1-a041-4016-84e0-d31047e4b415","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11151","original_object":"UniProtKB:P10275"}
{"id":"8aca04c8-ea87-4042-b085-46d7d0e1fc29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:10161","sources":[{"id":"urn:uuid:d555af76-5a32-4c52-89c1-0c26c897a350","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:P43657"}
{"id":"947b4669-e54d-4300-9838-4466eae4795d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086547","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:9e1ffb8d-61cd-4b30-81a0-017197a5c04b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:244","original_object":"UniProtKB:Q62758"}
{"id":"287c7991-c330-4147-ade4-51141df90c64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:32b32642-a705-45e9-929a-80275d5919e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P24046"}
{"id":"10e9ebfd-845c-43ac-b2d3-a02442d791e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:44677a3d-8466-453b-8c6c-5470ce4a37d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P20309"}
{"id":"44abc48c-a358-456f-82f8-be082310287e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817480","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:7a046a7a-83f3-4271-bc6b-daa92d7fb67b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6091","original_object":"UniProtKB:O88626"}
{"id":"46593ecf-d7bb-4a63-a501-4891eaf3d69d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76072859","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:bec727ff-cdf3-4fbf-b201-5dd2734a7c01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8219","original_object":"UniProtKB:O00311"}
{"id":"0d5ca179-3a61-459b-9398-b7f15bd41535","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5489450","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:310ef46b-8b8b-4821-96f7-487f97b3027f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:894","original_object":"UniProtKB:P32239"}
{"id":"986df096-0552-4b57-8087-f968d2443fd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6093160","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:3fb4a139-1634-4478-b879-79d91760afc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4266","original_object":"UniProtKB:P51575"}
{"id":"d9f2f559-468d-4533-a8fc-1608cfeb213a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135942","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:091d7173-af5f-46d4-9058-c99fe7b8c37d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3356","original_object":"UniProtKB:P21731"}
{"id":"851e0546-02b4-4d4c-b771-59963a36ffca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147075611","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:364eba83-d64c-4c26-8412-332314a4f4c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12643","original_object":"UniProtKB:Q14524"}
{"id":"8793c2ba-27bf-480a-bca0-efc25cc27654","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29009","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:e7937051-450c-4615-8b70-14ce1d46af88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1242","original_object":"UniProtKB:Q9QYN8"}
{"id":"f77a7e05-661e-4da5-b17c-1d7030f251aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:81326","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:0f058853-e589-43a6-86d5-258952b7b668","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6500","original_object":"UniProtKB:O14843"}
{"id":"0f9d1212-dc9c-410f-b293-c29f31cb7fd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:f90e52aa-b981-45ae-9811-ec76cc26f0df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P41595"}
{"id":"37f52183-b54a-492a-a8f1-9760d3915ce6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:e48bec0e-4e21-46b7-bddf-9c1583c4143e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P70597"}
{"id":"40c18f83-8b5f-4476-ab26-d4af68b1c0c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:721809WQCP","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:0720c23d-be06-40ad-bf13-04e4b9015de7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5263","original_object":"UniProtKB:Q05655"}
{"id":"31ccc6ab-d82a-48e4-a46f-92a4d05ab7d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13579","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:be658ee4-5f49-42f5-b68d-76b541f5b8e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13579","original_object":"UniProtKB:Q06418"}
{"id":"9b2e5ae0-c3af-410f-a263-c2a73186f11b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95083","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:b2698634-5f85-43c8-aa2f-61aaa90e0c3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7518","original_object":"UniProtKB:Q15059"}
{"id":"59173202-cc5b-498a-9c36-5477055d9bbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:217fac9d-1574-4c8e-a00f-a9b84b12c9d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:317","original_object":"UniProtKB:P08173"}
{"id":"a80b57df-e0e3-4560-8503-26946fbea425","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2719","predicate":"biolink:affects","object":"NCBIGene:29553","sources":[{"id":"urn:uuid:2209ac2d-1326-4c18-be7c-e292e39f5913","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2504","original_object":"UniProtKB:O54912"}
{"id":"6249396c-3f1c-4d5a-9170-39946fde4b08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311414","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:37f7245b-9f55-40d8-aca9-e659c5f10761","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3523","original_object":"UniProtKB:P30553"}
{"id":"8003aa4d-d57b-4996-b6a3-4efd583663a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q8MI0X869M","predicate":"biolink:affects","object":"NCBIGene:4193","sources":[{"id":"urn:uuid:c11b5419-6821-47e1-b036-bf747b4bcb17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9599","original_object":"UniProtKB:Q00987"}
{"id":"f8ec147e-b5fa-4650-82c6-0e4a000b827c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145712394","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:7e72e42d-e19d-4e74-b120-3db750574996","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10563","original_object":"UniProtKB:Q02750"}
{"id":"148c7461-5f5c-4c51-b6c7-8c26302dacbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51141","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:a3929596-f46d-4365-a7d5-e1f7c12f6579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7109","original_object":"UniProtKB:P35348"}
{"id":"86a550d4-4d27-4e67-91d4-bda914ade12a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5627","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:93e2f681-f843-49d7-82b1-18b7f5cf89bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5627","original_object":"UniProtKB:P30874"}
{"id":"46c69014-df18-47b4-a148-452e1a1a8635","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17198004","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:22ed98ab-e6f2-4e79-890e-31bb0d8b197f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11223","original_object":"UniProtKB:P29275"}
{"id":"e83ce173-65e7-4f7e-90fe-795e7327dfba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9097","predicate":"biolink:affects","object":"NCBIGene:8639","sources":[{"id":"urn:uuid:a79ab372-9778-46ad-870d-36524a47a728","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9097","original_object":"UniProtKB:Q16853"}
{"id":"952de032-e8e0-443f-9e68-dd0f3562db5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8493","predicate":"biolink:affects","object":"NCBIGene:2155","sources":[{"id":"urn:uuid:1c38f962-e4b9-4cbc-ab07-0a5530dff108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8493","original_object":"UniProtKB:P08709"}
{"id":"246f833e-ff7f-43e6-9968-316ae5837480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2220","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:68790e98-76c1-4d35-973f-fa90d6197639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2220","original_object":"UniProtKB:P37288"}
{"id":"638a0b35-a512-48ef-b0e5-1d0e88f1fc42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118160666","predicate":"biolink:affects","object":"NCBIGene:25302","sources":[{"id":"urn:uuid:0af0d6de-d7a5-440f-b956-6b10f82bed7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10693","original_object":"UniProtKB:Q05941"}
{"id":"ebcb9f35-b334-4500-b023-7d9c978971d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146267141","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:21644900-9d7a-43e5-a9e6-62f0c2fb29e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12075","original_object":"UniProtKB:O00329"}
{"id":"36d69b9c-724c-4cca-967d-eead53bec65c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6IJ842I0Z2","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:0e577466-9760-4bac-ba79-23f9e8b9195a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13314","original_object":"UniProtKB:P47871"}
{"id":"b3e6e2e0-1beb-481f-b448-e40856263627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41872","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:444e4a0f-56db-40b1-82c0-066fdd734ecc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2313","original_object":"UniProtKB:Q92952"}
{"id":"6c8f598b-52a2-4aac-8ec9-2c633d5e0f7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34649","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:348603b0-6518-4486-afff-afc75ef49117","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2507","original_object":"UniProtKB:O95259"}
{"id":"90df3a4e-b0d0-49d5-8939-17bd6ea7b9e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2057","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:6279ed9a-285c-4a86-9a87-15d4f3551bf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2057","original_object":"UniProtKB:P35346"}
{"id":"81f41538-7b70-47ad-96de-b4b5f96bac4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4615087","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:daea47d5-a1f2-4d45-9c40-b8b33ce2e6c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10295","original_object":"UniProtKB:Q9Y210"}
{"id":"bc109fac-1ac1-4da1-9994-40a2dc05f9bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1119","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:8ceee04a-19ac-46cf-a116-3b1aa731c231","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1119","original_object":"UniProtKB:Q02644"}
{"id":"9e945ddc-7653-48c0-b06f-2da35bf3cb3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3411","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:19d350fc-cc7e-4651-9bfc-7366c115a599","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3411","original_object":"UniProtKB:O88536"}
{"id":"f6117bee-1f05-4383-8fb1-b79d80fd318b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:94696dd1-bbea-437b-a6ee-03f45b86a8a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P28647"}
{"id":"2c4316b6-ae82-416c-84df-5fc72f8f0556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53232451","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:294f7360-6ed0-4543-951d-3d13e0ea67cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8123","original_object":"UniProtKB:P52333"}
{"id":"2296b11d-d25b-4cba-a0e3-74f60f5047d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:e1e92446-043e-495d-8992-712d5fe536c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:Q16539"}
{"id":"e6af3f98-f5f8-48d1-bc60-8908024d0557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:25da4a81-1c71-413b-add1-a18b1cca8d5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P08172"}
{"id":"b1f94b86-bda3-432a-8d8b-7301c9c2ee71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167900","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:ebf9bfbe-2d79-4757-9518-a78c34035ce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11348","original_object":"UniProtKB:P09874"}
{"id":"63d9d27b-da2a-4448-b193-62056e6bfa53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75441","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:20f89525-1d1b-4b40-a1b3-f1187ec43ed7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8408","original_object":"UniProtKB:P32239"}
{"id":"f965d20f-d03c-40f4-8b69-631a73947aa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3603","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:a0b712cc-8856-495a-a245-8ee7cae0d154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:308","original_object":"UniProtKB:P08912"}
{"id":"0c11b573-8939-4cfc-9845-b0b1ac2cba18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121485701","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:3437019c-71cf-40db-a074-52ae985fa2ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12584","original_object":"UniProtKB:P49682"}
{"id":"8f84fff6-bdb6-4639-987f-25deb836eb6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43871","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:b623b6a5-f1eb-4b88-85ea-2c9ad7d38036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5181","original_object":"UniProtKB:O75116"}
{"id":"c1516245-d009-4326-8bec-6e20b6c22b44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9959","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:46728442-5b31-46fb-b0b6-a1c186206639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9959","original_object":"UniProtKB:P55899"}
{"id":"de22c7aa-598f-46ec-b424-6782d575baa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CW55R761RE","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:2698a02d-6305-4407-9322-bd4c105396f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:290","original_object":"UniProtKB:P11229"}
{"id":"7eba0748-0f42-4e60-a276-6d1b6f4012b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2011","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:98744620-05d6-474c-889f-99a22b1cd483","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2011","original_object":"UniProtKB:P30872"}
{"id":"40fbb60a-0a3b-48a0-b2b1-156796158012","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134700","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:42268bae-8fdd-4e07-a864-77986d0a2c83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8375","original_object":"UniProtKB:P41180"}
{"id":"65b1086e-e1a1-4b7d-8aa2-3de398b3e138","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:75139390-5f13-42b8-b806-82ef6e19b037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P28222"}
{"id":"901d5767-0ebe-423e-916e-e3c4bc78ee02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7822","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:e20701fa-76d7-4a40-a870-0a70e0b43a8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7252","original_object":"UniProtKB:P34913"}
{"id":"c63e36df-68ac-4459-beb0-19a710b7265e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:95a1de46-42dd-4156-bd43-9f988fa7715d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:P29597"}
{"id":"34debab9-edf3-499c-b49e-ef6d84c5b1d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:671","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:e5bd1db1-dfdb-4e0c-9fb3-470122715de1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:671","original_object":"UniProtKB:P32299"}
{"id":"81d94419-f4c4-42f8-b44b-178ec41753cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1297","predicate":"biolink:affects","object":"NCBIGene:83567","sources":[{"id":"urn:uuid:f971802f-2aa3-4f69-8e6c-968fadfb45e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1297","original_object":"UniProtKB:P97639"}
{"id":"04c21989-a30b-46d4-8ca5-49be7f094af2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:683","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:589b87e7-fc0e-44b7-b851-dcf32427be5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:683","original_object":"UniProtKB:P30988"}
{"id":"2dc3f569-a1db-46f6-8de4-41eae5e57eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656400","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:3e28e7aa-414c-42b1-8aa7-756f779f7cb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1220","original_object":"UniProtKB:Q9H3N8"}
{"id":"0e0ca17a-91a6-4239-a514-2ce1d8781e96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92300","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:87e336fa-fd1d-44f4-a387-740344e94927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5982","original_object":"UniProtKB:P07333"}
{"id":"a0c70d93-95e7-44e6-a8d9-b4f02c27252e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45749","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:ba29598d-adcb-4667-a229-742d16a5ed50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2088","original_object":"UniProtKB:P25103"}
{"id":"a481d20b-9d8f-4371-8805-77e94b17749c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92375","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:5f47d2f4-dbc3-4ba6-8aa9-91898cbe9f50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6041","original_object":"UniProtKB:Q9NRA0"}
{"id":"afe5fb41-b7b3-4698-9b9b-74a6708ba233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:427002ad-5b27-43fe-b019-00a212e98785","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2491","original_object":"UniProtKB:P63142"}
{"id":"20f3f625-fb73-4a3d-9b11-6dcfc69489ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TL1UD860AA","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:52ef9f00-f514-4981-b30e-c519d7e58efb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12083","original_object":"UniProtKB:O00444"}
{"id":"073a627a-ddb9-4d94-bc11-6da5894edcee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45030","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:a4af3732-a861-40c9-b9b4-67377008b6d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6526","original_object":"UniProtKB:P45452"}
{"id":"c164d853-1c87-4504-bee0-8d43f5f53ae7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YS6K7Q8UP4","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:9374e0a0-87db-45fb-9614-9a31468f6007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:267","original_object":"UniProtKB:P32305"}
{"id":"4c34a10e-3058-4188-b6fb-d72c5b1eeba3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:a6b4e301-094e-4f63-99bb-47f2cb561de4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:P35498"}
{"id":"6a511b21-4368-4dc3-93a9-e586afeedad6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17253208","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:79b6d615-c239-482c-96b7-18ab72ec6f5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9494","original_object":"UniProtKB:Q99500"}
{"id":"3ccfa32d-011d-4242-b050-ba3d79162fda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:7c4530a8-2011-4203-9407-9c40c154671c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:Q62928"}
{"id":"1818c1a7-b979-44d1-8a78-c1f1acee597f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188651","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:5e22912c-0c6e-4b95-ac3a-161ac38a2c6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8403","original_object":"UniProtKB:P30559"}
{"id":"c84fa9e8-d0cc-4076-9348-0c9936eede1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2042","sources":[{"id":"urn:uuid:8c7dc510-1a2c-4550-a41a-02c1acaf577e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P29320"}
{"id":"41ac129b-7b2c-4f88-b655-8b01f0b7cb3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:599","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:72809605-0e83-413e-9467-fd0c61a33707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:599","original_object":"UniProtKB:P35414"}
{"id":"edfacfdd-b55e-424b-85b2-fbf5d00b9331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145994392","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:bc334f13-f1d8-40c5-aae0-a8dbe83dc5a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10687","original_object":"UniProtKB:Q13627"}
{"id":"33f86dc3-7cc9-43fd-93f3-508353afd6e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2525","predicate":"biolink:affects","object":"NCBIGene:774","sources":[{"id":"urn:uuid:8f592fcf-c90c-47d5-b2f1-a2444e601a42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2525","original_object":"UniProtKB:Q00975"}
{"id":"cf7442aa-6c9c-470b-899b-c5f44e056a38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:961606","predicate":"biolink:affects","object":"NCBIGene:4929","sources":[{"id":"urn:uuid:b4f1c10f-a4c1-407f-8b37-463d4a3f0795","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12997","original_object":"UniProtKB:P43354"}
{"id":"325759b9-c4df-4d84-ab97-2e9d453e80db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:59L7Y0530C","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:6f9070cc-48ae-4b70-8bd6-511ee64f373e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11619","original_object":"UniProtKB:P11362"}
{"id":"282073cc-a16f-4c4f-b886-452a02053cfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733034","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:23c0b687-73ea-4cce-8a0e-09419e8c479d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11313","original_object":"UniProtKB:Q9HBW0"}
{"id":"44ee4e1a-57ac-4fea-9de4-d5ebb3429916","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4A2Y23XK11","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:5294b6a7-0f81-4c18-b691-351f0ee183c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10136","original_object":"UniProtKB:P00533"}
{"id":"ba06d3a8-8b6a-42b5-85d1-1285724bcfd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25240297","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:1a44d5b8-f992-4514-b384-8068d0bbd608","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1283","original_object":"UniProtKB:Q969F8"}
{"id":"d64c85ea-c022-41d2-9854-d72cc382caa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:768FW21J3L","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:33621670-e8e6-4eed-80a0-ee8aa6c9339d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7886","original_object":"UniProtKB:P10721"}
{"id":"ec230466-02fc-4632-ae57-f59ee788217b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8458","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:616ee95d-9beb-484b-9620-2f2e4db71fc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8458","original_object":"UniProtKB:P07766"}
{"id":"70f54182-900c-4407-8ffe-6913a16b43f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9949081","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:1a0d1d4d-f6df-430e-92c3-4e02d5c9f781","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3136","original_object":"UniProtKB:P37268"}
{"id":"6c09eca7-581b-486b-81ff-7aa7075455e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44431042","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:a158b992-b3ce-4830-9136-b160e04c13ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1383","original_object":"UniProtKB:P23385"}
{"id":"48bc0708-f196-4a6e-bdd7-7aaba08f5fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321147","predicate":"biolink:affects","object":"NCBIGene:233079","sources":[{"id":"urn:uuid:a1372c0c-c812-460e-8d2a-330ef1b370ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10107","original_object":"UniProtKB:Q8VCK6"}
{"id":"8f91315a-c2bf-4b43-82c7-6b666c9e6224","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5339183","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:499a7019-6fe6-4afc-8605-7e6dcb47bd95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5968","original_object":"UniProtKB:P28482"}
{"id":"fa4486dd-e5b6-4a24-b3d4-842e14babba3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24867852","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:d8c4ef44-c617-426b-abc9-d4e1b1541b40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1720","original_object":"UniProtKB:P47900"}
{"id":"461896da-f38d-4b51-9b63-6e4ff5927a92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7582","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:bee13b6b-bbc3-40b5-9695-e9da4e4acd94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2334","original_object":"UniProtKB:O15554"}
{"id":"3d6947cd-5748-43c2-8b3e-b9dbdd7c6fdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8673","predicate":"biolink:affects","object":"NCBIGene:55244","sources":[{"id":"urn:uuid:a2ca2b55-5510-49c8-8c67-e9f05f219743","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4800","original_object":"UniProtKB:Q96FL8"}
{"id":"b9ca936b-f0c5-4a86-9fff-a6201756be47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124085867","predicate":"biolink:affects","object":"NCBIGene:29933","sources":[{"id":"urn:uuid:5d08194a-2db8-42ca-9f5d-c4e04d090d35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11337","original_object":"UniProtKB:Q9UNW8"}
{"id":"4815c486-854c-423b-a318-d26c1f153fd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93613","predicate":"biolink:affects","object":"NCBIGene:610","sources":[{"id":"urn:uuid:308d6b4f-8ada-4626-9c72-2115fa2ea806","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2358","original_object":"UniProtKB:Q9UL51"}
{"id":"95befd56-3a1e-4bf1-9d6c-fd4b84ac33d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:17G8FN2E1F","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:5dab599f-f295-494d-acc6-7f95beec6229","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3510","original_object":"UniProtKB:P25103"}
{"id":"db7e30ef-9f71-438b-8bf0-352f1ec60984","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1872","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:6a05fd5a-a8bf-4ddf-a502-a095326aa94e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1872","original_object":"UniProtKB:P49683"}
{"id":"26d4ba25-6d11-41b5-b2e8-4f9560059de7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BL51M8CB8R","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:f28c78ef-ddf8-4a48-b1a1-a709054aece5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7862","original_object":"UniProtKB:P43235"}
{"id":"a0a4d1ee-2b96-4402-ac7c-bd6ba91908f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129320519","predicate":"biolink:affects","object":"NCBIGene:1147","sources":[{"id":"urn:uuid:54f83dbf-5bac-4207-a8e6-7e4e633467f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9646","original_object":"UniProtKB:O15111"}
{"id":"14a8f16d-4b2c-49c0-8efb-3dadee92b767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755211","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:49624272-6064-4488-8937-79df2df69a04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6364","original_object":"UniProtKB:P23385"}
{"id":"6fb72c4b-087e-4845-94d4-6d7608900676","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10141039","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:c666fe0c-1806-4834-adfa-853dbe6e6a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5854","original_object":"UniProtKB:P43119"}
{"id":"74c92ece-1692-48df-829e-ba6f227d1ed1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:10804","sources":[{"id":"urn:uuid:32b51fec-d771-493d-822e-4cef7b76a39c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:O95452"}
{"id":"fe038a8b-581e-4fe6-887c-2cf05c0400c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155587867","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:d365e3c4-91f1-4e34-9b0f-5de7f678be8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11510","original_object":"UniProtKB:P10721"}
{"id":"b7edefcb-b577-4f07-8691-ef715eeb9973","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:168SF9F04E","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:db883ba3-27ce-445f-b391-45a26baebba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5617","original_object":"UniProtKB:P29275"}
{"id":"6d563b26-90b3-404b-9a9b-88732d2409c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59896759","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:6c3fc911-fcc3-4c56-8df0-8b161b098cfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4369","original_object":"UniProtKB:Q16445"}
{"id":"3580295b-ea41-4155-9ec8-b4611d3cd852","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11494579","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:83fe62e8-99a1-4445-ad3a-23751f72996a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5791","original_object":"UniProtKB:Q8TDS4"}
{"id":"9d314536-2294-4f0e-92cb-9f30e392fe12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:a09348f9-d554-45f3-a779-b76ab55ddc14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P20309"}
{"id":"557fe2e3-728d-4e54-b364-d5ab0e806c71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135242204","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:1b317a7f-3fd4-4bd3-b926-32a3d767ecf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12280","original_object":"UniProtKB:Q96P20"}
{"id":"1df14798-85f3-4c23-8dc5-b938e27a3ee8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165404856","predicate":"biolink:affects","object":"NCBIGene:11113","sources":[{"id":"urn:uuid:c09e2314-c7c8-4c3e-a600-a62e6ac522ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13171","original_object":"UniProtKB:O14578"}
{"id":"a324eba4-8bbd-4805-af24-e4f39db86930","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94302","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:244d5b68-11ca-4f09-a71f-e90b23e034af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8011","original_object":"UniProtKB:P48736"}
{"id":"758d7bbd-d7ef-4fe9-80d9-58ee8fb68d60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:be78ecd0-be2b-4398-a52b-9f570bbb257a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P22002"}
{"id":"99fdbb16-114b-482c-afb7-2fbdd1fb42c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3699","predicate":"biolink:affects","object":"NCBIGene:55366","sources":[{"id":"urn:uuid:87ca311d-fd27-4284-a121-af75ca067541","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3699","original_object":"UniProtKB:Q9BXB1"}
{"id":"2e00e1af-d316-4be4-aae9-109e86c791d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393288","predicate":"biolink:affects","object":"NCBIGene:283927","sources":[{"id":"urn:uuid:73897c15-d569-4d90-87e0-156a9b84096f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10384","original_object":"UniProtKB:P0C024"}
{"id":"52d14dcd-9ca2-4ff2-be0c-840ce38d3786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2237","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:f5212eaa-d456-43d5-bd04-d6a0cd0fb67b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2237","original_object":"UniProtKB:P30518"}
{"id":"7d17bb96-56e4-4b77-ae69-e2d18a9298cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7662KG2R6K","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:a743ee2a-44ef-4499-b481-ccdbab38e4ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4242","original_object":"UniProtKB:P51788"}
{"id":"e262db2e-194a-47d2-8376-8e6997436673","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3970","predicate":"biolink:affects","object":"NCBIGene:1138","sources":[{"id":"urn:uuid:5b3a86c5-bf0d-473a-a5ad-e69e0cf45ed3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3970","original_object":"UniProtKB:P30532"}
{"id":"416cfe79-1473-4806-91d3-26db603dc0ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136003","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:a875a24a-088e-4a60-a71e-f5dad1d6bc43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1605","original_object":"UniProtKB:P41143"}
{"id":"daaed077-9cda-4dfd-9fb4-932a5bd9f444","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8495","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:88ac6009-32a9-417f-8a52-4521d9b5ea9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8495","original_object":"UniProtKB:P25025"}
{"id":"2d117162-60c9-41f4-a026-b76e39eb3daa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8493","predicate":"biolink:affects","object":"NCBIGene:3818","sources":[{"id":"urn:uuid:cd3558b6-5b59-412b-910c-853a40be278b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8493","original_object":"UniProtKB:P03952"}
{"id":"1ab75254-ad5d-4b06-ad94-2c05678909cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:6f1c2f97-4979-43bd-9bbc-f2cef1e57f86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P21918"}
{"id":"787c9619-db9a-458b-b229-1797bb618d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:917eb7ec-b4ed-48f6-889c-2552c35992d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:P22002"}
{"id":"6a221d6f-9f78-49c4-b063-585428f0ccfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68575","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:b377d58e-1420-4f24-991d-792e74d2b6fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7455","original_object":"UniProtKB:P08588"}
{"id":"dfd009cc-6a4e-4e19-a966-c3c4dcecaa4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13876","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:a0b93327-2e3e-46be-a58f-f1c6faa8b96f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13876","original_object":"UniProtKB:P55899"}
{"id":"44d93b05-9395-4471-8f12-3d14a14f7f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44543082","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:ee7370a1-ce18-4f03-acb3-1033aed7eca0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8153","original_object":"UniProtKB:P53671"}
{"id":"1c901f08-1e55-4e5b-801d-97a81ffe9a84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:dbb44b77-e7b5-48ae-aa92-de5e35567ccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q17ST2"}
{"id":"a098f10c-3a9b-4ba3-801f-32e23aea339f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31468","predicate":"biolink:affects","object":"NCBIGene:476","sources":[{"id":"urn:uuid:eeb98b8e-4a93-49ff-9423-a642a7d82551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6806","original_object":"UniProtKB:P05023"}
{"id":"415a098d-6a59-4053-83b8-62233931cba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:830","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:6882ef95-da04-4a78-9e39-0685e68b2d8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:830","original_object":"UniProtKB:P25025"}
{"id":"fcade5e1-21ea-4d28-836a-d162d4e212ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4952","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:98166a77-7659-4abf-abea-0152e7b232ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4952","original_object":"UniProtKB:P16066"}
{"id":"7f559de1-6dad-4029-afc9-4284a532f075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755035","predicate":"biolink:affects","object":"NCBIGene:25075","sources":[{"id":"urn:uuid:4ad9a973-1ee2-4bb2-b3d1-c85a69fe2618","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3250","original_object":"UniProtKB:P28564"}
{"id":"ed68cb10-ba15-4350-aa88-f49bcb541f6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1806","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:5936c2fb-50bf-47ac-98da-fe0f00e359ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1806","original_object":"UniProtKB:P25961"}
{"id":"27e2a554-cffb-45e4-9326-9e881cbb1ab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9844711","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:ee56b3da-f6ca-445b-88d2-fcb31dd02a8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:746","original_object":"UniProtKB:P34972"}
{"id":"20d39081-0322-477f-8cc9-06090f094c94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11100382","predicate":"biolink:affects","object":"NCBIGene:1562","sources":[{"id":"urn:uuid:6ec5e370-c356-43b8-9fbd-3b2996077af8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8833","original_object":"UniProtKB:P33260"}
{"id":"9c80a4e7-02e8-4eba-bb16-e30c4fb4c6ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11245456","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:ca415c69-5ec1-470c-8b83-d7495876d5da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1422","original_object":"UniProtKB:P31424"}
{"id":"893920eb-5a60-46d6-8c6d-e894f903cb93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32010","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:05659abc-312a-43ba-bf95-3d5b5263a02b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4288","original_object":"UniProtKB:P42261"}
{"id":"e7733a6b-ce35-4706-9b93-d8069745a656","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:2580","sources":[{"id":"urn:uuid:40ec06e4-b8f8-4cb8-808a-5aee0c8509b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:O14976"}
{"id":"2228fcf5-b79c-4f4a-ab91-28d9c56e41b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:01025148-2f46-429d-a504-5d188d0957dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:342","original_object":"UniProtKB:P20309"}
{"id":"74ddbd75-c3d9-49ac-bb95-975bf5e38052","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M64JF6WMSA","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:16093d05-a644-4ebd-8c31-449007474c46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9768","original_object":"UniProtKB:P22455"}
{"id":"78525da0-682a-46ed-ab6a-0d6e237d3acb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4814","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:d2a0e53d-6108-4af5-9ea8-fcbdb9ada014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:588","original_object":"UniProtKB:P30556"}
{"id":"28113270-5df7-4ece-af91-d4ece67c0aa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93243","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:f29ec3f2-a174-4ada-92ca-ecfd306dc568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7646","original_object":"UniProtKB:P00533"}
{"id":"4c4ef466-2906-4def-a9e7-3e1e28955985","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:c15c58fe-d33c-4ae3-846e-a448b0a96dbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:Q62928"}
{"id":"92c84acf-5fa6-4d70-81c3-787ced4d16c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131180","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:f47e2516-69ef-444f-8d7b-9d280e57fb71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:567","original_object":"UniProtKB:P13945"}
{"id":"7efd8451-32c0-40d2-a732-1533e0af9aaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:39e862f2-6061-44df-b0b0-1ebf96255ae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P43114"}
{"id":"b260ef39-e646-4c58-b15f-e8269b1b5278","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9486","predicate":"biolink:affects","object":"NCBIGene:6565","sources":[{"id":"urn:uuid:c7fda3e2-64d5-4232-b5de-35f1bd5b3888","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9486","original_object":"UniProtKB:Q16348"}
{"id":"ed7c02fa-ac12-4acb-a92b-b732cafc9eec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63959","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:1eb72a0a-5163-4263-9331-d2d53ee38668","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10386","original_object":"UniProtKB:Q9UGC6"}
{"id":"2c7c618b-ba40-446f-8e72-7595791dd6cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2027","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:4ed4c04e-b5e4-4619-aa9a-849a20c47a2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2027","original_object":"UniProtKB:P32745"}
{"id":"2ee8915e-26a8-46bf-9097-0f4c86a25cf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10296414","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:63a6a21f-320f-45a2-bbef-281c408bba00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:76","original_object":"UniProtKB:P28221"}
{"id":"3e2ee501-4d84-4b92-bba0-60ca8d26eabc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12652","predicate":"biolink:affects","object":"NCBIGene:961","sources":[{"id":"urn:uuid:c928385f-0f24-46c9-8009-228c0608dbec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12652","original_object":"UniProtKB:Q08722"}
{"id":"09f739a2-a031-44ce-b0cf-341b68590c21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FD2SWT2SDI","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:bc486255-ce4e-4714-8738-5341b4a5a54d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6045","original_object":"UniProtKB:P11802"}
{"id":"b6e3682f-524a-4d74-bb15-f8364ea0242c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50908800","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:58a366c0-f8d7-4842-9661-4d5c4dee4aa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7057","original_object":"UniProtKB:Q9UBN7"}
{"id":"ddf0f37c-3e00-4924-bfe5-41937bd9d02c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2Q5861SUIG","predicate":"biolink:affects","object":"NCBIGene:1361","sources":[{"id":"urn:uuid:2a650b24-2208-4efa-abaa-5d2add8ef9db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8657","original_object":"UniProtKB:Q96IY4"}
{"id":"dfb323e9-6e5d-43bc-98f2-13cf609762db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7851","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:f5a598f8-8f41-48a3-8c09-74c823a094de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:302","original_object":"UniProtKB:P11229"}
{"id":"fb8ed37a-3f81-42be-8236-873be242d534","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0Y175XGX4P","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:51003f01-eaa0-4ce3-9a65-d2b02a1fde04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12145","original_object":"UniProtKB:P03372"}
{"id":"a4540998-9782-414b-a619-8046e64f9a31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16137682","predicate":"biolink:affects","object":"NCBIGene:2861","sources":[{"id":"urn:uuid:de4bc326-1ba1-4989-917a-c2c28f0020b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6067","original_object":"UniProtKB:O15354"}
{"id":"ad1a3231-48b4-4a47-8834-936db857f4e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124929","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:c374d780-432f-425d-a902-6ef68b0450b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9377","original_object":"UniProtKB:P45983"}
{"id":"94983464-9ba4-4d73-8e84-b76795241f0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4293970","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:b7b794f0-d511-4818-aae9-efedb60622c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10151","original_object":"UniProtKB:P06239"}
{"id":"e2ce02fc-b097-4722-8096-aa17e032e725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"NCBIGene:5063","sources":[{"id":"urn:uuid:b41281bb-3bd8-4c77-9c41-98f8df7933d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:O75914"}
{"id":"e08c772f-554c-44cd-8c53-f9476b9e633f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440220","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:6363c176-1739-43e2-80d3-05302590e09c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2911","original_object":"UniProtKB:Q9UBY5"}
{"id":"170f3678-4fb2-408a-9f4d-9a0a58f69931","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2046","sources":[{"id":"urn:uuid:fc33f7e0-20b4-443c-b980-88a68b58cfd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P29322"}
{"id":"ff8baa7e-63e3-40b5-a52c-cb9a653bdf15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4722575","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:f96d9197-3eff-42f4-8a66-eed6adf872f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8288","original_object":"UniProtKB:O14744"}
{"id":"0804cb7e-32c0-4172-ae9c-69380c1a9e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50859","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:0283160c-c0f5-48b1-944d-5745ba9a1789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2807","original_object":"UniProtKB:P19793"}
{"id":"827f0a89-d3e5-487f-b76d-6b8fbe21ef81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21037647","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:88c43edb-f45a-4d17-acfd-b0239647fb13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2473","original_object":"UniProtKB:Q8R455"}
{"id":"b773ce67-3763-4b24-b60c-9dc871d29cb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:e95cea7b-0c41-4b9c-8897-a7a1ab517634","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:P35968"}
{"id":"0a639de0-620e-47a6-b3f8-56ea3fb06f1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:74ff06c8-70bd-431c-accb-8ba44812bc6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P29275"}
{"id":"42c62450-7a71-4a77-9ecc-f95b21bd6c48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232977","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:aa82b6da-6222-40a2-ae5a-036786ca14cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10671","original_object":"UniProtKB:O95271"}
{"id":"25b00d4a-5fb3-4625-838b-4eb138a427fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:772","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:65518d50-3e23-4592-8b32-2f4ccc192e9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:772","original_object":"UniProtKB:P32246"}
{"id":"16709926-5de3-4f4a-a0e3-926fa6b97714","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KNM216XOUH","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:7d69fce9-7ec2-49ee-beb3-1867ae1f4b4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7712","original_object":"UniProtKB:P48039"}
{"id":"2069acf6-8bb2-495c-95e5-a033860f260f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167574","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:027e92f9-50c8-4cdd-bb1b-b4025733f4f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9724","original_object":"UniProtKB:P43220"}
{"id":"6e21bc2f-89e3-4b59-b315-090e3f1d875b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:ec4fedac-918a-4765-846f-0f96d8868411","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:P62508"}
{"id":"c344efd1-70cc-4fd0-88a0-a977d6eb4761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5329829","predicate":"biolink:affects","object":"NCBIGene:197259","sources":[{"id":"urn:uuid:ca1286d1-63ad-4ccf-af13-bc64984bb1ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9513","original_object":"UniProtKB:Q8NB16"}
{"id":"91635907-d44c-47dc-9bba-875d602245b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:937","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:c78cffd8-e408-43cd-8e9c-6b9d1c7cf8a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:937","original_object":"UniProtKB:P21728"}
{"id":"821fd28d-45e0-45d4-b703-696c262d9021","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118335773","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:830c5ae8-a13c-4a1d-84e4-c05efc7e4c9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10887","original_object":"UniProtKB:P14780"}
{"id":"09412029-d8c4-41f2-a31d-a9d17ffd397f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:146227","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:918fedeb-a74c-461e-aecd-d948a78504ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10703","original_object":"UniProtKB:P45983"}
{"id":"0d4370bb-46a5-41fc-ab55-d6e2e3959e00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754996","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:c36693a6-5a0b-414c-8ad3-5e2a99a7d3d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:562","original_object":"UniProtKB:P13945"}
{"id":"a6d98287-d4c3-4a18-a79e-76c2496d7f7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2219","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:2a4427e7-ac5d-4543-b2e2-a2183b551e5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2219","original_object":"UniProtKB:P30518"}
{"id":"09d183a8-f81d-4746-954a-762261ee2d1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46866191","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:f7989f0c-ae6c-4c35-8088-7166ab56a9ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6209","original_object":"UniProtKB:P23385"}
{"id":"863a462e-809e-4bff-9084-75d7045f6664","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10981286","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:86b5adb3-e941-4d06-8a0b-e1cccfcc7b63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5599","original_object":"UniProtKB:P29274"}
{"id":"7e561200-900a-4159-918f-a10fdaa1d927","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9690136","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:0e52f5f3-2483-4d2e-96f2-c49947c70e3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2192","original_object":"UniProtKB:P70536"}
{"id":"0e3697fb-0832-4edb-ac21-6b98844553f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:34ZKU73FU3","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:fc23aafd-c59e-4bfa-a600-1eb6a4813d32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9061","original_object":"UniProtKB:P08235"}
{"id":"8e56ab20-9f8b-43d8-97e8-2dbc8e939298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95089","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:17f0c88e-98d6-40f6-8271-0e83bbd15c8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7887","original_object":"UniProtKB:P31749"}
{"id":"9477b20e-e7cf-4598-b1e7-5f2835b926af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:6941bc72-6719-474d-90d0-06ff6e66da54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P21917"}
{"id":"bee6558a-7bf7-4c19-88d1-25a5c6209d7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:88B5039IQG","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:78ada563-b511-4fcb-b17e-b38bd8ce090a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6285","original_object":"UniProtKB:O75762"}
{"id":"4130a5c4-7dee-42da-9379-b3551b585196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:fee4642f-90d9-4862-9663-3720ebceff7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P41595"}
{"id":"e5d23fe8-4ada-46c5-8897-30a7f1bd15fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15811","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:e5130aaa-9550-46c2-a807-01d59066e9d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1411","original_object":"UniProtKB:Q14831"}
{"id":"c646c10d-cdaa-4d01-8c41-0472c4b51c81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:06e6cc1d-965a-4c7e-9d1b-302ed1aac55f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:Q08345"}
{"id":"905e2f27-cbb3-4d9d-b8bf-7cac677ad515","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL499968","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:ab6ec469-8229-4b1d-83cc-c8893623a79b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2317","original_object":"UniProtKB:O15554"}
{"id":"46bd963e-a85c-4cc3-9bcb-6917fc82ffac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3921","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:c9791f94-e5d7-4629-915f-13c70f5aca2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2413","original_object":"UniProtKB:P15388"}
{"id":"ec21d3b0-7b3d-49f9-b3cb-649f1f8761b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15864","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:4c808eab-c1fa-4186-bc1f-dcaf401eb565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5215","original_object":"UniProtKB:Q9NYV8"}
{"id":"a2572309-8ff6-4891-b48a-ae4cd0998629","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44132853","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:193d7abe-4e11-48e3-99ea-48e30a3194fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9814","original_object":"UniProtKB:P06239"}
{"id":"cf588fba-cd80-4f13-82a8-c727a78246d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:54822","sources":[{"id":"urn:uuid:3c831bf0-e353-458e-8e8e-b31fb9813b74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q96QT4"}
{"id":"e29b495e-5cf8-4727-ba2c-67a80df8666c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91340","predicate":"biolink:affects","object":"NCBIGene:1147","sources":[{"id":"urn:uuid:6fa17836-efb8-4bad-8889-4558c9c437ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5669","original_object":"UniProtKB:O15111"}
{"id":"bcddb29c-b234-4ec1-9f49-a4f9aba94281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129188708","predicate":"biolink:affects","object":"NCBIGene:221955","sources":[{"id":"urn:uuid:a5fe6c7a-b020-42b4-9823-357dd5125596","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10243","original_object":"UniProtKB:Q8NCG7"}
{"id":"3dd3f91f-4fb9-4597-8fd6-da37c6eecb8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827366","predicate":"biolink:affects","object":"NCBIGene:6534","sources":[{"id":"urn:uuid:6c02c01f-f352-4670-98b7-edfda96fc38c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8520","original_object":"UniProtKB:Q99884"}
{"id":"4c19100d-1d51-467a-998d-838baeed4182","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996533","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:2c912f3a-163a-4356-916f-5cfdac68e576","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10634","original_object":"UniProtKB:P00533"}
{"id":"6be8c4d8-b892-4608-9016-20e17ca396b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QRT7W0TL6X","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:6367ec1d-6609-4080-a37e-459880a446ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9329","original_object":"UniProtKB:P25103"}
{"id":"b332fa0c-f2b6-4e61-8575-232977caced4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114786893","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:f8aabe90-8056-477f-82ee-b85b4fada307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13697","original_object":"UniProtKB:Q13526"}
{"id":"e227fe87-a6fa-40f1-b9d6-4d65787e2508","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321165","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:fc71c2c4-ccca-4513-8e86-753dd635545a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10185","original_object":"UniProtKB:P35372"}
{"id":"826abac8-7e1c-456f-86d6-7beff010aecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16113","predicate":"biolink:affects","object":"NCBIGene:6095","sources":[{"id":"urn:uuid:050f251c-58af-4485-a4c7-aa8957c73154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2718","original_object":"UniProtKB:P35398"}
{"id":"bc57c3b3-866a-4679-83fa-0bfc49b1b00e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9911728","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:f7545eb0-2749-4ba0-b4a7-4b6eb70f49c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11810","original_object":"UniProtKB:Q96P20"}
{"id":"53b42485-5bad-4c40-a714-62225835fef9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:2dabd8f1-3e31-481b-9698-102a2e4035a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P08069"}
{"id":"d2d2e8c0-da8d-4854-802a-b3a3e88e421a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:8476","sources":[{"id":"urn:uuid:ba57a7e9-c59a-43ae-a163-8445db5f2d45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:Q5VT25"}
{"id":"9be78c84-579f-4faf-84da-869b911550eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1659","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:8e5b8737-654d-4a98-84e1-86b6ae332f59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1659","original_object":"UniProtKB:P33534"}
{"id":"2246a00c-b061-4f42-aac5-05ce204e8031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321156","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:ac367b50-a396-4d05-adc3-f0a78934fd46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10148","original_object":"UniProtKB:P29597"}
{"id":"ddad67ab-662c-4607-840e-e8e771d772dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2772368","predicate":"biolink:affects","object":"NCBIGene:111","sources":[{"id":"urn:uuid:dc282d80-cef1-4527-9dbf-bd9d2a7834b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5233","original_object":"UniProtKB:O95622"}
{"id":"5e4226d4-2991-4709-80d8-81efbc61c711","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6663","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:a64e350b-1b9f-48dd-a345-a39800a1fd48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6663","original_object":"UniProtKB:P35348"}
{"id":"563604b2-fd2a-4d44-b3a0-01eb1a3d4833","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2856","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:c2213d08-73c6-4629-a4dd-df1c9fb9ec51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5955","original_object":"UniProtKB:P06493"}
{"id":"14c77cce-3e87-430a-9a9b-763b51686b58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191396","predicate":"biolink:affects","object":"NCBIGene:5566","sources":[{"id":"urn:uuid:bf89bbd0-2d90-41ca-aabc-036fb3e4794c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5983","original_object":"UniProtKB:P17612"}
{"id":"9fa16d82-d47d-403e-9bcf-8da94641a24e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:eb7d8204-064a-48a7-8c15-b69885d7dd67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P31388"}
{"id":"149f5dfc-bd05-4874-88e0-4084d4319cb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8416","predicate":"biolink:affects","object":"NCBIGene:30061","sources":[{"id":"urn:uuid:0d39c6c1-c86b-49cd-b28e-04de42cdbc0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8416","original_object":"UniProtKB:Q9NP59"}
{"id":"f1a3021a-da09-480d-bd1c-dd2ddb2db357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XI179PG9LV","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:e5c12076-5ab8-4705-a756-b50ad9dd54fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9059","original_object":"UniProtKB:Q13639"}
{"id":"73504eb1-e375-4872-9bc9-76834b7b429d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847835","predicate":"biolink:affects","object":"NCBIGene:842","sources":[{"id":"urn:uuid:ad0ec586-effe-4257-8207-8aa2d062c3b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6515","original_object":"UniProtKB:P55211"}
{"id":"854f73e5-4795-42c6-afb2-6d6bf75bd3cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13946","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:9101fccd-e559-401b-9447-8257cd128c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13946","original_object":"UniProtKB:Q9GZQ6"}
{"id":"cff9ab3e-363e-4506-b8a1-d8a33e1c7955","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9915610","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:2b42ddf5-b487-459a-a176-deb6a7530019","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:790","original_object":"UniProtKB:P51677"}
{"id":"88a8a73d-1ba1-4476-9be0-edb6feb09ac0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2455","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:b9d24e6c-95c2-4c0a-be51-77f90273e885","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2438","original_object":"UniProtKB:Q9UL62"}
{"id":"6dadfe3e-14d3-454b-9857-2287d567d0d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:a8dc656a-a994-4801-b564-3efbdac52fac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:P47211"}
{"id":"4388dbe9-4d05-4496-93bc-0131fcdf3db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34795","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:49da069a-12ef-4b53-a478-e21b43defc2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:388","original_object":"UniProtKB:P30542"}
{"id":"2cf11447-50a9-4359-b975-c48e2bdd300b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:2a6987e1-c442-4432-92e7-5d8cd22b7169","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P23385"}
{"id":"1b1d8cbe-aa8e-4fa6-8a0b-710d4d73b753","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:961YV2O515","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:686156a7-f0bb-4fe7-93cc-6627e74a3b98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9777","original_object":"UniProtKB:P55899"}
{"id":"d05686d0-e8e8-445c-97d3-99f680db2ffb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VI6E2D3CYP","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:7c4828eb-5da3-445e-8bd9-a494c6f6dfe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13167","original_object":"UniProtKB:P04150"}
{"id":"129a4431-117f-469f-b0c9-9e69fc4a0110","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163839","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:3d6eb29d-fb6a-4eb8-a0f5-a8f3a7e5c02b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:268","original_object":"UniProtKB:P31388"}
{"id":"e5a26e35-b1e9-4614-a3c2-11c256744233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:77951f3d-f703-4aa6-9c42-ff9d08b8b7bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P35462"}
{"id":"b26c9c17-fbfc-4ab7-a106-10c52818f99c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817485","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:87ce3cee-f4bf-43bb-a661-6538c007aeaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6121","original_object":"UniProtKB:O43603"}
{"id":"3ac6ac47-fb50-4e2b-926a-7bec3cff6cdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2053","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:0268d07e-3fa1-4f98-b395-9041fc652ad7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2053","original_object":"UniProtKB:P30874"}
{"id":"54b7a89b-0d4b-45c8-b5b0-2bb7e6c02a28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94810","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:23c0fca8-6731-4d73-ac88-771cdcfa2509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3634","original_object":"UniProtKB:Q9Y271"}
{"id":"9da3741f-ec0e-4af8-b1a9-728685f3f6f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3500","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:bc301608-33bd-4941-b36a-6aff30a79e1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:335","original_object":"UniProtKB:P08172"}
{"id":"a3e0ec10-f128-4e9c-be08-aaa529eb8f47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135018","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:28dfc69a-4122-4a18-8d8e-53d45f4dbbc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1610","original_object":"UniProtKB:P34975"}
{"id":"399331fa-5d22-49c1-94f0-0c73171eda8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11749893","predicate":"biolink:affects","object":"UniProtKB:P31651","sources":[{"id":"urn:uuid:b25c841a-5529-4937-93e8-90d8367b6a46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4756","original_object":"UniProtKB:P31651"}
{"id":"aaa517d4-27b9-4c44-80d3-2e0f5062df87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10389239","predicate":"biolink:affects","object":"NCBIGene:7867","sources":[{"id":"urn:uuid:cc3bf065-e15c-46bc-ae0e-03fe0903f7be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8177","original_object":"UniProtKB:Q16644"}
{"id":"620b9244-f3f6-4b11-bd9f-2fcfb47e7b61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52936849","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:b180069d-a903-4321-8e0a-8a957d5c7da6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8243","original_object":"UniProtKB:P42336"}
{"id":"b333344c-d03c-46a3-b3d3-a0b335ebe062","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3921","predicate":"biolink:affects","object":"NCBIGene:3764","sources":[{"id":"urn:uuid:ec33b905-2e54-409f-a5b6-b1b3212de9ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2413","original_object":"UniProtKB:Q15842"}
{"id":"2452040a-6eb4-45cc-ba0b-4fde85bf6445","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95073","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:8117f4b1-fbe5-4da1-a53c-3c89bcc01940","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7010","original_object":"UniProtKB:Q9BY41"}
{"id":"fc76f964-502d-460e-a3da-ead71910837f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47575","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:b3b8d49e-a05d-4107-80d6-0ea63784d8b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8320","original_object":"UniProtKB:P10415"}
{"id":"21ca3cad-a8bc-4387-a214-9e8cbad629ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757050","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:db1a3fe4-458e-402f-8b2d-fe384ae04949","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12730","original_object":"UniProtKB:P35372"}
{"id":"039b7368-92e9-4a63-8442-1b6be480e91f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1V3OH20HG","predicate":"biolink:affects","object":"NCBIGene:29665","sources":[{"id":"urn:uuid:9f189ef0-7ef3-485b-a064-d7eb68064de7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10504","original_object":"UniProtKB:Q64663"}
{"id":"cbc632d5-04e8-4d13-8482-cdf0362700d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10067","predicate":"biolink:affects","object":"NCBIGene:2214","sources":[{"id":"urn:uuid:676ea594-b152-40fc-8dca-178febdba045","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10067","original_object":"UniProtKB:P08637"}
{"id":"dcfde8b6-3d49-4392-8cf9-e4eaa4310d09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755042","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:84c863c1-4933-4362-90e1-fa8221b86ea8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3337","original_object":"UniProtKB:Q15391"}
{"id":"51944fab-b04d-4202-83c6-6751d58f6908","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:0f7d6a32-e2e3-489c-b5d1-5c0e7b84603a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P25100"}
{"id":"3561ba2e-6cef-4671-82fd-62c8ee8f54fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:01bf3d92-025f-4142-99ac-3116817c5d16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P28566"}
{"id":"918343bd-dc51-4b84-9039-537e18606c51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:20181","sources":[{"id":"urn:uuid:ae97ac75-f8c1-4c3b-94d3-a3eee4db91ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5383","original_object":"UniProtKB:P28700"}
{"id":"ee2370cf-4de2-425a-99dc-3d2e90caf03b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993635","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:619df596-02d2-496f-a3dd-db1b715668d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12334","original_object":"UniProtKB:P45983"}
{"id":"7295a33e-b8d9-4686-b92f-6b150e438e52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QI52W1ZIIB","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:c77131ba-3639-4027-a46a-649efdcab6db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12084","original_object":"UniProtKB:Q9Y243"}
{"id":"4f0dad77-2251-4b95-81f8-e0c40dbe2588","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1686","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:19706137-6a6d-4c0d-8541-7c487f908690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1686","original_object":"UniProtKB:P41146"}
{"id":"02350313-78f4-4091-bcf1-29b1cf54b0b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137441492","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:10e187c6-44cb-49a9-9427-28b307cd6342","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12155","original_object":"UniProtKB:P29597"}
{"id":"97d1ba2a-54eb-41be-8d4f-9287c67323f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43689","predicate":"biolink:affects","object":"NCBIGene:493809","sources":[{"id":"urn:uuid:0770f906-c250-4aa5-890b-65bbe9f2be97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5506","original_object":"UniProtKB:Q5QD16"}
{"id":"bdbc1855-e398-40aa-9025-ba183c90ca3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947087","predicate":"biolink:affects","object":"NCBIGene:4597","sources":[{"id":"urn:uuid:9aeb4fa9-076e-4f1f-b5ab-efeb50d67832","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3207","original_object":"UniProtKB:P53602"}
{"id":"02b0e379-0c54-427e-b345-73f4bd0ed998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QI52W1ZIIB","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:4692e5e6-c282-410d-9c09-09ad55d83e4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12084","original_object":"UniProtKB:P31751"}
{"id":"bb50385d-402c-4988-beb5-f65896ed04fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:a5065a00-754d-4ed8-b92f-02d507c1d043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:Q62928"}
{"id":"d9d28ba7-8152-4866-b349-693f0deef4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9937534","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:42aa87f7-e338-41f1-b5c2-c485f6402761","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:621","original_object":"UniProtKB:P24053"}
{"id":"1d1b5c85-60c3-4f6a-b200-43124b33919b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93822","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:d6dcdb8d-0301-4e2b-a7c9-953c645f999d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1367","original_object":"UniProtKB:P23385"}
{"id":"9f0495f2-3284-4d38-8be9-666bcc441af7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13793","predicate":"biolink:affects","object":"NCBIGene:1493","sources":[{"id":"urn:uuid:7beb0bd4-e4ac-4e77-be8a-07104292dbb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13793","original_object":"UniProtKB:P16410"}
{"id":"610c4395-8273-4a8e-a8bd-e6972c4d823c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15428","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:f7319d3f-43d0-429c-92a0-2653134f066f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:727","original_object":"UniProtKB:Q13224"}
{"id":"fd629931-490e-43fa-bfff-7ca090afe466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:c7561673-da75-43d9-81be-69fbe1f95534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P28222"}
{"id":"6529572d-3295-4d64-bd04-b7bfad1a3f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40303","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:ea649060-1c52-43f8-8c3f-041fac1486d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2739","original_object":"UniProtKB:P04035"}
{"id":"29dcab94-0dbe-4ff9-a4d6-3d2b9431480d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10247549","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:8475809c-c2e9-4d9c-bf6a-42fa303bd4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:392","original_object":"UniProtKB:P0DMS8"}
{"id":"f4048295-1539-4ee7-8fbf-e027afef93d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16325","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:66d1f4c3-608d-4620-8b84-f293ae6110f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:611","original_object":"UniProtKB:P11473"}
{"id":"90b91f5b-af0a-48df-87dd-91a2bbc1a560","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:797","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:2bce72ca-7fb1-4a67-b5cb-c7ea3d18fd27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:797","original_object":"UniProtKB:P51679"}
{"id":"18f83ad6-bdcb-49ca-8fc6-c57f82ce4aa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53319341","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:85984b84-6f62-417e-a2ee-62daf1250543","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:406","original_object":"UniProtKB:P29275"}
{"id":"aa7671f7-e21f-43fe-b6ce-70dfff6f1fec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103931","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:16313ee7-50eb-494d-bb63-e3e3ba9427c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:487","original_object":"UniProtKB:P35368"}
{"id":"1de198fd-bc2f-46d4-8b93-16b121f12112","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45302","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:89359fca-8716-4a53-b513-7a56c9454540","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6023","original_object":"UniProtKB:O00329"}
{"id":"32e5398c-c2db-4ccc-97b4-3e210d6f2d25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MS6LGW5JFK","predicate":"biolink:affects","object":"NCBIGene:5538","sources":[{"id":"urn:uuid:ce9d53b5-3f03-4d26-b5fa-bed6caef6abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11991","original_object":"UniProtKB:P50897"}
{"id":"a3b54ded-6d0d-46e6-b371-6db6727fd356","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817418","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:0afc8c8e-06ab-43f9-be68-dd7b2068e20c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1510","original_object":"UniProtKB:Q15761"}
{"id":"190d1acf-e62d-4ceb-adcf-1a9fdd69e5c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132992142","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:6b85903a-1cf6-4ed2-8c58-74244775f52c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9929","original_object":"UniProtKB:P06239"}
{"id":"bfdf5af9-9663-4d32-b38b-76d207695347","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9947","predicate":"biolink:affects","object":"NCBIGene:7162","sources":[{"id":"urn:uuid:3c51a91b-3d47-42c4-baba-2427fdff0b54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9947","original_object":"UniProtKB:Q13641"}
{"id":"1290601f-c55c-404d-a040-7238816e967b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4A2Y23XK11","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:fa85679e-0a71-4ce2-8571-f8badb4f0179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10136","original_object":"UniProtKB:P52333"}
{"id":"95b2b0cf-e38b-4ee8-9901-f84b1a02e36e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6073","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:cecac812-8fe1-46da-9005-1825ce522378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4488","original_object":"UniProtKB:Q01668"}
{"id":"a66d5526-ab5c-4599-bc88-81a8eb3968d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156297592","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:0f1b0755-ea23-46fa-848f-17535e81d971","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12095","original_object":"UniProtKB:P15056"}
{"id":"c6a808f1-72f7-4d13-b2ea-e1d64243cd0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310960","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:6b0fc1e0-ccc2-44c7-9f1e-0c0fa27de904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:459","original_object":"UniProtKB:P29275"}
{"id":"2f8f705a-afaa-4fd8-97d6-7816f1a57b7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:09ZFC7974Q","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:89ce1df4-897d-41da-a2b4-47ec9363749a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5175","original_object":"UniProtKB:P24557"}
{"id":"237d3ff5-4d1b-430c-a257-645e1cccfb36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X5DCA09N30","predicate":"biolink:affects","object":"NCBIGene:9572","sources":[{"id":"urn:uuid:637226bb-e2f5-4406-824e-6cbbec1f45b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8901","original_object":"UniProtKB:P20393"}
{"id":"61f34647-0cc5-4626-8128-efd03a1fc68d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34727","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:29e8d6d8-f8c9-4976-aa74-ccd8565bbf5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4181","original_object":"UniProtKB:P39086"}
{"id":"acaf1dd1-c6b4-414e-908f-88be6fa48363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5TD9324Z2U","predicate":"biolink:affects","object":"NCBIGene:18","sources":[{"id":"urn:uuid:37a5e51a-9934-4e65-8ded-b4303fff0257","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8284","original_object":"UniProtKB:P80404"}
{"id":"954720ae-9e8a-42bf-ba6a-9385b398817d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2614","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:bfe87dbf-451f-46bd-8e14-56239330907b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2614","original_object":"UniProtKB:Q99250"}
{"id":"b9509963-be63-4a6c-bdaf-238ac647d146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92998","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:8c1390ba-39de-4fba-91b2-40b20ee99a75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5443","original_object":"UniProtKB:P08913"}
{"id":"773a397b-cd9e-4d5a-89c0-a01dd3c70d17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92941","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:0c9f1394-edc0-41d6-8f2d-07da39919fa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1704","original_object":"UniProtKB:O43613"}
{"id":"0f9e5b56-f19f-4d08-8e3b-ab0a14fd1f01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1545","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:c3ae831d-4f70-4306-bc45-e9f08a2f98c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1545","original_object":"UniProtKB:P50391"}
{"id":"00a578d5-be51-414d-b509-e1f8cde2bd62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441294","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:fb64f7e8-b1e7-4f8e-9df6-12217c394ff7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1862","original_object":"UniProtKB:P23415"}
{"id":"1e4dea2a-978b-4f3c-97c2-8193650eee2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:3222a1cb-ecec-4147-8bcf-6bf53490434d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:294","original_object":"UniProtKB:P08482"}
{"id":"81bfd4bf-ca90-4a9b-a93d-9265c6f4363f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5289549","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:f8a60881-f518-4108-a43f-fd60b388301e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2776","original_object":"UniProtKB:P11473"}
{"id":"77bd3d75-d675-495c-a6ee-a79ebcb85d83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:437","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:312de56c-f4d0-4050-aee4-82e7fcabdf54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:437","original_object":"UniProtKB:P29275"}
{"id":"ce1d7f06-8da7-4a44-a283-6f3a12be1033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9907616","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:c819df0e-0ae6-4c55-b42f-ecff3cb150aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8461","original_object":"UniProtKB:P35368"}
{"id":"efdc564b-517a-4836-9ef8-57e315336150","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900912","predicate":"biolink:affects","object":"NCBIGene:22848","sources":[{"id":"urn:uuid:7ec20e04-b1e4-43af-affa-2f7448c36c75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11893","original_object":"UniProtKB:Q2M2I8"}
{"id":"47d84a11-b2d4-4f38-8a1d-8cd6ce100d96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:5c86dfee-4e90-492d-91cf-2d0353c71875","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P35348"}
{"id":"2ce532a7-d5f7-41bf-9b81-a25398acc91b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10344307","predicate":"biolink:affects","object":"NCBIGene:4316","sources":[{"id":"urn:uuid:bfdecf28-6aa0-42a9-b0f6-82c2c8f02cbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8629","original_object":"UniProtKB:P09237"}
{"id":"1cf26780-2b9a-4a7f-985e-1af48a66384e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195541","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:43ff7588-ee83-4fe8-bd6b-0cf3b44a0554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2917","original_object":"UniProtKB:O95136"}
{"id":"31e6c9d8-94c9-4f0b-9b2e-1b34806cb539","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:aab66456-7d74-4ac9-abb8-30d1e0c2f5f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P32241"}
{"id":"69d711e9-9902-4b05-b8c6-ca558f3f72e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9734","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:9dfec58b-dc60-4131-af7b-e0b12d53364c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9734","original_object":"UniProtKB:Q92847"}
{"id":"850d1ef1-42e5-4f21-8e83-f445d17741a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C23O3R93BM","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:7db4153a-8f8c-4bf2-b82b-71d1d441e8fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10695","original_object":"UniProtKB:O75116"}
{"id":"a92439ed-01fd-47dd-8477-6b3132864fd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13769","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:9db27e02-5010-4e64-b056-b8f6248de133","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13769","original_object":"UniProtKB:P48546"}
{"id":"43d8754c-30a5-44d0-b913-8806aa4b52d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104129","predicate":"biolink:affects","object":"NCBIGene:132","sources":[{"id":"urn:uuid:df965c9e-4f15-4f44-b6b6-e3d0c309e247","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5131","original_object":"UniProtKB:P55263"}
{"id":"7942477c-0ee2-4032-b628-2343788719d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8874","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:16c43db1-ab3c-4ef2-a756-d21cc913cac4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6602","original_object":"UniProtKB:P22303"}
{"id":"1d3fb75f-dbd0-42bc-9e00-8c2f2875a9fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90531","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:99642b02-af84-4c81-bb82-ac11b9ea6481","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7946","original_object":"UniProtKB:Q05655"}
{"id":"c4ea7a5b-b995-4088-af23-ea0db938ffec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134824567","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:f8a9c11a-e5b7-4eb4-88a0-8b8f240c6586","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1301","original_object":"UniProtKB:Q99705"}
{"id":"bc72a064-bdcf-46bf-b18d-17b0294eb7b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56933304","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:bd93bc11-f270-4de4-a3f6-8f31d22e1449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13220","original_object":"UniProtKB:P08581"}
{"id":"bfd80e31-a35e-42f1-b006-5a321646e230","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:23b7d99b-8817-4948-8ca9-15e3dc29abe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q9WTR1"}
{"id":"310e147d-25f3-4c8d-9fe4-2723f00841cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7244710F59","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:8ef720fd-7bf4-43e2-a410-1027d90b1479","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2675","original_object":"UniProtKB:Q07869"}
{"id":"1f912758-84d6-47e4-a105-baa3f2022c55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393285","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:00113af1-f56f-46ca-b8d6-5133ac40dc2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10351","original_object":"UniProtKB:P30542"}
{"id":"c6578715-d1bf-466d-9764-37b1e87d186a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X8GF945GMK","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:75134713-89de-45ef-a92f-9acd07228edd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11897","original_object":"UniProtKB:Q02127"}
{"id":"a7ded247-11db-41dc-9fbc-079deee9a90f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58525066","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:e4bce840-130e-4504-a55c-5349a524241b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9692","original_object":"UniProtKB:P48736"}
{"id":"eeb00089-2e85-4292-878f-3e33805e745d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:e78ffe3c-7b3f-4a4d-943b-d8fb0db9a3ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q8BLA8"}
{"id":"186cd306-3e39-4cc3-99e4-d2f43c0a9d65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5276531","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:726d0484-2088-4e26-85cd-6a05338c31c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3171","original_object":"UniProtKB:P14324"}
{"id":"3a0ffa08-a00e-4c5b-a719-04458dbb41ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:84694","sources":[{"id":"urn:uuid:ca18ff06-d3a5-46b1-8367-87e5454bce4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q969M2"}
{"id":"5fbad7c0-2fab-4763-93a6-cf3d09eaa081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:158617","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:a620e73a-5eca-473c-bae7-187620680b8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2733","original_object":"UniProtKB:Q01668"}
{"id":"1860558b-677a-4202-91e2-21319f9b979a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:549dc11d-0186-43fe-bbb1-86da73ce4205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:Q00535"}
{"id":"19707048-1e9b-4ebf-9977-ed4be8e3dbda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1207","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:4bb47c21-f107-430d-94f7-600b95e75849","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4089","original_object":"UniProtKB:Q13224"}
{"id":"7788060c-cb09-4efd-ade3-f43aff958d53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15940","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:099bf960-af88-4c33-a954-c36364c45a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1588","original_object":"UniProtKB:Q9BXC0"}
{"id":"2f1b80aa-bb66-461f-b8b9-9ad4c13ecc46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92538","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:09171791-d0db-4117-9abb-dcc50bff951c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5191","original_object":"UniProtKB:P23219"}
{"id":"1bda6b8d-3447-47fe-8eb8-6545a5ff4e33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9B0H171MJ","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:d6bb5b06-43fc-4489-9c80-7fc1dc858d2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9785","original_object":"UniProtKB:P11362"}
{"id":"dd3b0763-d79d-4e07-bd58-21f71bba8bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54751698","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:1c3f9e72-0b8f-4773-8bd5-51dd15ab9289","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8968","original_object":"UniProtKB:O00329"}
{"id":"37952d68-dd19-4005-ba99-69d042912523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40279","predicate":"biolink:affects","object":"NCBIGene:7498","sources":[{"id":"urn:uuid:e4c72811-e4bf-45d0-af7d-373e4c87832d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6795","original_object":"UniProtKB:P47989"}
{"id":"3857533b-f47b-427a-8d1f-b5f3a16ef41d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155590998","predicate":"biolink:affects","object":"NCBIGene:2145","sources":[{"id":"urn:uuid:a2a5424a-8ccd-4668-9fce-29e63e164e74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12615","original_object":"UniProtKB:Q92800"}
{"id":"ec4f41d9-20ef-46a6-bca7-740d51496973","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:8645","sources":[{"id":"urn:uuid:011b4275-fcdd-4d6a-8344-7d98d8586163","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:O95279"}
{"id":"33d6a69b-a427-40db-8ec6-a2b92ba7ef39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5147","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:cd787c12-5a94-471f-abf4-adc91275efe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3465","original_object":"UniProtKB:P08588"}
{"id":"dd3293bc-309d-4220-952f-7e539342b98d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:fd701f0c-3279-4692-8c32-5246dd8104ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:O75116"}
{"id":"1c35c25b-26b9-4036-80f7-edb4f51c1a73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12361","predicate":"biolink:affects","object":"NCBIGene:84868","sources":[{"id":"urn:uuid:2051a7a6-3206-484e-b592-db11947a6abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12361","original_object":"UniProtKB:Q8TDQ0"}
{"id":"dfce4edf-86c9-47f3-b935-5a2491971f52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9817231","predicate":"biolink:affects","object":"NCBIGene:18391","sources":[{"id":"urn:uuid:a45d8b96-8f7b-4aa1-95dc-e84320f09f31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10731","original_object":"UniProtKB:O55242"}
{"id":"112dbd8b-e2a7-4891-9819-6f6ffcf3bed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6015","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:d5ff26f4-e5ac-4ec1-8a98-5fa0786facab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2505","original_object":"UniProtKB:O95069"}
{"id":"5581612e-5bfc-4419-a967-9a7d3c516177","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15A52GPT8T","predicate":"biolink:affects","object":"NCBIGene:3645","sources":[{"id":"urn:uuid:79d7dbdd-3547-4886-80b4-671f13ea80d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7423","original_object":"UniProtKB:P14616"}
{"id":"b1be28c5-fab9-44d0-8a03-ceabf34bb8ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890547","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:4cd1087b-bb97-4774-b76a-3d0267e0171e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:490","original_object":"UniProtKB:P23944"}
{"id":"a516f5ac-8c9f-40e3-aa23-d1613768c78d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86007","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:cf825340-d544-47b2-beca-f5d38077fbea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5938","original_object":"UniProtKB:P24941"}
{"id":"b49c8e18-c072-48b5-8e31-f91ca5f08f64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817488","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:ab557b94-c55b-4e5a-97be-47c5cd1b33bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6165","original_object":"UniProtKB:P52500"}
{"id":"b4827eb1-4e83-46ff-88fe-daf7cc57d1aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:2fb9d4a1-0cb0-423f-8f10-e05f1f65c788","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:Q9ERC0"}
{"id":"a74329fc-5d8a-40ec-9faf-829289b78bb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4709","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:55968514-8b04-4557-af6e-eb19af31ab39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6017","original_object":"UniProtKB:P00533"}
{"id":"1cf4ab9d-3168-43d6-88b8-487b02783dc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:408160c3-7ab9-4e8a-83c8-c247e2ac7225","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P35916"}
{"id":"6b58e759-397f-432d-b883-731764387ffa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755086","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:f852eef4-4f27-42f4-9322-a78125b77cac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4220","original_object":"UniProtKB:Q8K424"}
{"id":"69513b46-6b23-44a1-b638-ee70b964bc67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92272","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:d6ea1130-8802-4817-b384-3d968c0a867d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1277","original_object":"UniProtKB:Q9H3N8"}
{"id":"21a7491f-21db-4a95-bdf5-daa35210476d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080554","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:02627ade-fc6b-41dc-b464-d92fe451e03c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4216","original_object":"UniProtKB:Q12879"}
{"id":"a6cfc7c8-5aa3-4371-9904-ae4f175fbe36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q257O24H4J","predicate":"biolink:affects","object":"NCBIGene:834","sources":[{"id":"urn:uuid:cc51db23-6fab-4536-821e-d08c918a8f87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9034","original_object":"UniProtKB:P29466"}
{"id":"6903c026-0045-4ca3-99f5-e861ce08441d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39912","predicate":"biolink:affects","object":"NCBIGene:243270","sources":[{"id":"urn:uuid:d5770058-b3c8-4431-9402-3f878ac11bd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5783","original_object":"UniProtKB:Q8C131"}
{"id":"2bfb349b-a697-421f-8a26-c609484b5295","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:cf6ba77d-aa36-497c-b34a-3008db3eee50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:P48736"}
{"id":"dfda4c28-ab72-4a83-9848-4228855a2d69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47519","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:af4b5adb-78da-4f61-a8ca-40c2a9bc1282","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11829","original_object":"UniProtKB:P05093"}
{"id":"3b4a851e-d058-42d9-b958-29ae7156276a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:762","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:07183ac6-d1f2-429c-bab7-34c83f99abb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:762","original_object":"UniProtKB:P32246"}
{"id":"92957e79-6aa2-49d2-aacf-e2ed0f1a7096","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68764898","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:a6589a9a-a857-47b6-a621-3605775e76b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9430","original_object":"UniProtKB:P41597"}
{"id":"c19f6295-171e-4512-bcb3-4f80086addf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RCA38L4HB5","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:3f5d4268-afc8-49e8-a86a-4c213dce91c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12382","original_object":"UniProtKB:P42336"}
{"id":"945a81dc-3144-40ac-b0b1-2396de2ac857","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699463","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:8d8c1763-8505-49d1-a84b-8d1c50d6a59f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11220","original_object":"UniProtKB:Q92769"}
{"id":"86441fd2-6ba8-4ac0-8f76-30098d93ed15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:dd20cd4b-4740-49c2-b3aa-b2df9644105b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P28223"}
{"id":"e49d7ddb-3257-46f5-9394-e253796b0a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RRN67GMB0V","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:811fefd6-6dbe-4964-bbe0-a61140672ce8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10552","original_object":"UniProtKB:P13569"}
{"id":"dab38f61-b45d-4098-8bbb-49ce335456d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433304","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:965d0be4-32ad-4d7e-ac8e-d948e6389384","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12801","original_object":"UniProtKB:P05093"}
{"id":"1f191cb3-e6fe-4759-9b82-e07c90cd1400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890547","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:4e9812cf-015d-4d15-afc7-9b10d141c405","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:490","original_object":"UniProtKB:P25100"}
{"id":"634c5f23-2f15-42a9-aac5-53d546fade1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92539","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:3c52e67c-b2b6-47f5-839a-30f9869ff5a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9","original_object":"UniProtKB:P08908"}
{"id":"b1bd2778-1f40-4a05-a3f9-92b1e292e691","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:100126572","sources":[{"id":"urn:uuid:6a13ea2f-100d-4be8-b1a9-0682fb72c0a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:A6NN92"}
{"id":"404b314c-a213-4eed-9592-6cc67170d2c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9439","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:4cbb850b-572a-4135-b749-6b12e59c372c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9439","original_object":"UniProtKB:P49684"}
{"id":"0b21a824-f8f5-405f-ba22-d27a58f86357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93387","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:5baf619b-c50a-49dc-995a-503fdab82205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:742","original_object":"UniProtKB:P21554"}
{"id":"6a8324a4-e356-4d6f-b512-e0506ce9ff97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131152","predicate":"biolink:affects","object":"NCBIGene:5927","sources":[{"id":"urn:uuid:f147a0a8-9c56-4473-ab0d-835b02eb94fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7027","original_object":"UniProtKB:P29375"}
{"id":"03f96dea-e229-452a-a161-d1ae77fa63a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53384841","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:e106d7f9-0ba7-4027-8c4f-1df983ac1d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6423","original_object":"UniProtKB:P31424"}
{"id":"b28fa8f9-e71e-4d0b-89e5-eace61c3d844","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8024","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:76f309f1-6225-48a1-ad79-12fc4ed7a402","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6367","original_object":"UniProtKB:P12821"}
{"id":"4e7ff298-2b74-41c9-a2f8-1ec4aa7aed9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135470","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:13dd0950-3bcb-48fc-b9bd-68203d91c3c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:501","original_object":"UniProtKB:P35348"}
{"id":"976ab5d3-9d16-46f7-b4f9-c7f6695720d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80266","predicate":"biolink:affects","object":"NCBIGene:18389","sources":[{"id":"urn:uuid:0c4150e8-edf6-4433-8b40-81e4b52ed8ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1681","original_object":"UniProtKB:P35377"}
{"id":"97f6c363-ea1b-49e1-8086-83ecb63d3d14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1514","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:dbc44122-e542-40e6-95b0-4fff102885eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1514","original_object":"UniProtKB:P49146"}
{"id":"b5f22cb7-9fb8-4ac5-aa0c-e93afcedcde9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56597775","predicate":"biolink:affects","object":"NCBIGene:8408","sources":[{"id":"urn:uuid:1a0c505f-5121-45c6-ad0c-34b38e3690a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8213","original_object":"UniProtKB:O75385"}
{"id":"f09011ce-e184-4633-adf0-81b25b0eceaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:d48ad851-24d6-44be-b63b-2d2a7e74dcae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:P17252"}
{"id":"74a1450f-b2f0-44f0-a71d-00dbb51e7a0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:c791207b-287c-4f43-887b-123dbb06346f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:P15390"}
{"id":"8eaaea7c-09c4-4bd3-a48f-9904e94d8049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231409","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:b82a1a8f-a5c8-4097-bf1d-9cd6ca8563a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9192","original_object":"UniProtKB:P41145"}
{"id":"f28f0e33-eed8-474f-9fcc-40c597f5aa4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5V9KLZ54CY","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:67f4d942-fb3f-4b81-a2f6-29d67ecb4187","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6851","original_object":"UniProtKB:P07437"}
{"id":"9a6717c6-1310-464c-934e-688d73ba7378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2758","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:91b279e2-fd33-46a3-af34-a68c554e9d1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2464","original_object":"UniProtKB:Q8R4D5"}
{"id":"7eb8bc68-2df2-44e6-9fba-697d0286613d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:769","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:8712b4e4-71a6-45ff-ac65-6f41982243e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:769","original_object":"UniProtKB:P49682"}
{"id":"0186fb45-349d-44c2-ae85-478185717dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6096","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:636a10ba-40b3-4921-b530-66b9c5a9c421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6096","original_object":"UniProtKB:Q62805"}
{"id":"79f88baa-5e68-4d73-9e4b-d331dbb0de8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6666","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:656b5133-8352-4569-8b3c-b5a78dab489d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6666","original_object":"UniProtKB:P32239"}
{"id":"774f71cc-0f28-48a2-8c5b-81931818768c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45409","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:7dc4ad18-866c-42e9-93f4-2c896b5429b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8804","original_object":"UniProtKB:Q9NYW7"}
{"id":"de854765-0c03-4c30-975b-6f2c806edcaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:8cb89798-fa99-4496-9053-f14ec05390ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q9P0X4"}
{"id":"8228410e-2144-4ef1-ab4f-1c9fd4532bf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OPM23UN90U","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:a553f01a-4d3d-400f-b85e-e5e2511b75bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9650","original_object":"UniProtKB:P04150"}
{"id":"ebd850c0-cd6f-4e6d-a58f-fe783d7a1c53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RN9I7K5RVN","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:36bd2d4c-305e-4e66-a4d5-53454d5f4656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6679","original_object":"UniProtKB:Q99720"}
{"id":"a2332305-8019-45cb-9191-1c79a5342dd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9757","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:66fb6149-6db5-40e8-b19b-f8594b970098","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7319","original_object":"UniProtKB:P20309"}
{"id":"feb22d80-4f19-4e29-83ca-49ec63ac6708","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109538","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:1247c091-779e-4d5e-b1ce-b1a51c327429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:385","original_object":"UniProtKB:P30542"}
{"id":"28ae400e-c1e1-4810-9296-53cfa64c59b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42797","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:7a74bcab-0627-4e12-98db-9611a691ee0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5483","original_object":"UniProtKB:Q9NR82"}
{"id":"2a1b0d17-1062-4991-a51c-a876b7257291","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900913","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:5e656ab6-3014-414d-b492-b7bc760653e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11895","original_object":"UniProtKB:P29597"}
{"id":"75b11056-356b-4033-a785-b8dcd2f06a68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:41702b92-02ea-4d37-a37a-0e71b3944301","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q9UBN4"}
{"id":"1e5eed27-a262-4de1-a886-39a70e29806f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:478573","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:fc441d3d-a32c-4359-98b6-02f8302a1e1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10126","original_object":"UniProtKB:P14902"}
{"id":"49b429be-377d-4027-a75c-ccf8a99a7722","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132986","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:0503f3a9-edef-4931-ad12-9025ee0815fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7717","original_object":"UniProtKB:P00533"}
{"id":"7ea67bcf-6638-4396-83ba-430f19695c0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9927707","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:62c199c3-4e41-4c0b-8fb7-65c70f3152c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4248","original_object":"UniProtKB:P42262"}
{"id":"92d8c91b-cdd5-44dd-ac3e-c72e3be302e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2035","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:3db2a606-1afe-44f7-89b1-f2f232e1e73a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2035","original_object":"UniProtKB:P30875"}
{"id":"9801c5f3-8cc5-4cae-8c22-2c6297e70b86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947056","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:78c8866c-900e-42a1-a73f-6a11b40ccf89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3063","original_object":"UniProtKB:Q02769"}
{"id":"dcaac5d2-7e82-4290-84a1-45b3173f8869","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QQM82D8YUP","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:d14a190c-9cd9-4bd6-9d84-0e350795f65c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:881","original_object":"UniProtKB:P32239"}
{"id":"d2cfe777-efda-4f14-a097-1983c0cb6318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1G916IMD7L","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:aeccfa42-47f6-406a-9f39-9c981f2c16dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:61","original_object":"UniProtKB:P08908"}
{"id":"3fae6c02-76d8-425c-b741-75042d291809","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8382","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:e5aa5947-b450-4524-9992-ff12e3822055","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7096","original_object":"UniProtKB:P04150"}
{"id":"b08d3046-b50f-42c8-b2ba-a61e4d26ecf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92848","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:6d23f384-71e8-4a14-b9d3-9438cff22e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3286","original_object":"UniProtKB:P0DMS8"}
{"id":"8f27a5de-7a43-44a8-a354-79d724e82dc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030525","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:432cf683-e1f3-4ffd-9bc7-174ce23b5e85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10444","original_object":"UniProtKB:P30559"}
{"id":"d1faf976-4653-4319-8d3b-93d5cdd758e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N7T15V1FUY","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:ee16f0b6-2b91-4c9a-90c2-0c7542ee23ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9272","original_object":"UniProtKB:P41968"}
{"id":"a4aeca11-c151-4822-a309-6617ffbb016f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:128805","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:ed716ae7-0088-4818-8ee3-673465316991","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:511","original_object":"UniProtKB:P23944"}
{"id":"29c7d5cd-0a89-4940-be6e-aa4be79124cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68513937","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:313d9395-5380-44f4-b978-b8b5847d673c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10064","original_object":"UniProtKB:P48067"}
{"id":"788fb6dd-8a89-41a8-8ed2-b30beeba6e04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9589","predicate":"biolink:affects","object":"NCBIGene:80381","sources":[{"id":"urn:uuid:8ea99fc4-6e09-44d5-b846-958598e43904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9589","original_object":"UniProtKB:Q5ZPR3"}
{"id":"72731d7d-92a9-42eb-921d-b2fb0b536267","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5697","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:55b0b1c5-6d5d-4be7-a6a4-2ba0b42f78f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:404","original_object":"UniProtKB:P28647"}
{"id":"ccfdbff7-71f7-4fd1-848d-e6f457425432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:147398","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:0a3dfd50-9c15-49f6-8383-ee17282cc804","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6929","original_object":"UniProtKB:P49841"}
{"id":"d04cd956-4bd5-4304-ba81-8fc94a99104c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168355580","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:47050c4a-f0ae-41a8-b563-8a8a2bbc4782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12776","original_object":"UniProtKB:Q13315"}
{"id":"829b5959-1967-4086-ace2-8984ac9ac41e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137754","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:e652fb12-5358-4103-87c1-e50e1f0a557c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6164","original_object":"UniProtKB:Q8TDS5"}
{"id":"172c466a-53ca-4bc2-ab15-e40483271d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:177cddc5-20bd-4f17-a194-ed71662d7f11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P35367"}
{"id":"508b5de1-3007-478d-bcc1-47f81245083d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91824786","predicate":"biolink:affects","object":"NCBIGene:23657","sources":[{"id":"urn:uuid:cb801663-39b3-40d9-944b-10b9bfd3b509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13930","original_object":"UniProtKB:Q9UPY5"}
{"id":"ee83e6d3-7614-468e-929c-ba657966cab2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9851134","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:ca3033d1-a50e-43d7-9bbd-27f91fc9ea29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8654","original_object":"UniProtKB:P42574"}
{"id":"7e2b7ba6-6195-4e8d-ac7f-ea6c51bc5f2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1290","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:99a11d2f-8050-4928-ba09-c3b6bbea74c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1290","original_object":"UniProtKB:Q99705"}
{"id":"60c8549c-4796-4c07-8b88-f14089fd9e2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311216","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:b42075b1-fa9b-4f65-8916-b83251bfecba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:749","original_object":"UniProtKB:P34972"}
{"id":"833e423c-7b79-47ab-8195-aad4cc6fbc2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:203905","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:b674a069-0bb2-4dde-8f8e-0a4c1e35364c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13408","original_object":"UniProtKB:P17252"}
{"id":"bfcb28e4-b297-41ad-b6a2-2bdae1c91cd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1023","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:ddb7367b-48c6-41a6-b05e-486f8ddc2dcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1023","original_object":"UniProtKB:P33766"}
{"id":"5b2c7c15-cfeb-4a4a-b4a6-095317ab995f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:910","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:94a8752e-2f88-4eea-8f81-e1b19fb2cf5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:910","original_object":"UniProtKB:P32239"}
{"id":"05fdc07d-1977-4616-bd10-f7442d77740d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13572","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:1f26879f-1884-4674-b74c-152e3c44527b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13572","original_object":"UniProtKB:P07711"}
{"id":"e25da9b8-e754-4613-b27c-3a6f21fa93f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53259050","predicate":"biolink:affects","object":"NCBIGene:4012","sources":[{"id":"urn:uuid:3b9045b6-cf3c-4581-b1e3-979fe58de922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8621","original_object":"UniProtKB:Q9UIQ6"}
{"id":"3a627a1f-6b0a-4379-b8a9-47a1511ba40f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2028","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:4395e833-1286-4050-b99d-74aea515daa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2028","original_object":"UniProtKB:P31391"}
{"id":"c5ec839c-4240-4efa-b4c4-bf7ccda74d81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49662","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:0ebad958-d26b-4065-866d-965cce25ece5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1909","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"3d1d1efb-ca9a-4e6e-9c57-ffe5bec4cbcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93781","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:7b88fd89-d341-4897-b466-bfaa5adf24fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6030","original_object":"UniProtKB:Q00535"}
{"id":"d0720816-d5ac-4c09-a41a-706f5513fc45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2248","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:ecce42f6-2f97-4ec3-8877-0b335d25baaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2248","original_object":"UniProtKB:P30559"}
{"id":"4aa9e25a-889d-4848-8f16-f0739321163a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:01J7526K2Q","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:3854bb4a-dd6b-428f-870b-6d43a1aa0183","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9569","original_object":"UniProtKB:Q9H228"}
{"id":"493cd674-d1c8-4131-a41b-a7b728ad36ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6107","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:3664d8bc-0c6a-44d7-95a1-ee66884ddc4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6107","original_object":"UniProtKB:O43603"}
{"id":"97acd131-b509-412f-ab05-2f4c7b38209d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3N422P20J8","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:31c54f76-443f-4120-b4b5-a898eb89aa9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4368","original_object":"UniProtKB:P31644"}
{"id":"f65446ec-ca47-4c09-91d9-82720dc5f3aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134427646","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:60f1d237-b829-452b-a3f5-29338a00e8dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13486","original_object":"UniProtKB:P48736"}
{"id":"2403d47b-5653-4fcb-8903-34894e70a634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21226959","predicate":"biolink:affects","object":"NCBIGene:1244","sources":[{"id":"urn:uuid:05d5dd6a-f74f-4e71-951d-80a76df42756","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8776","original_object":"UniProtKB:Q92887"}
{"id":"063c18bc-3fe1-4917-961f-8999aaecfeff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34144","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:f2e2c34d-b04e-4a49-8457-0d80e5da95f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3405","original_object":"UniProtKB:Q15722"}
{"id":"d3885ccf-b311-4f55-9d1e-552aca7e7e0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:cfeaea16-38a9-46a3-842f-a3abf683e2e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P0DMS8"}
{"id":"c35fbd0b-6867-454e-8d4a-8af1c7427689","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DH5W8F3S4H","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:03fa003c-7b88-4d40-89a2-db97528cc143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1969","original_object":"UniProtKB:P43119"}
{"id":"ed0293a9-fffa-4c40-bff5-8ad0b6cbc4c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5T0XWC07Z","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:8b2c0baa-a113-4033-b410-1dc4f1146b28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9942","original_object":"UniProtKB:Q13315"}
{"id":"c208d58c-728c-4b36-b7bb-1c9f811be75b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1207","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:f9a1030a-9126-439c-93b1-03418f5d71be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4089","original_object":"UniProtKB:O15399"}
{"id":"e89132d0-a0a0-4851-8924-d6dae5e25284","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82701","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:4c6c7585-da66-4573-8dfb-d126f0cac384","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6741","original_object":"UniProtKB:P42338"}
{"id":"cd727e54-9279-41f4-88bb-f7bc6e94e695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4023","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:36ca7cbb-a386-4bb7-9590-f3a8f5d70e23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4088","original_object":"UniProtKB:Q12879"}
{"id":"172f4a4e-5c89-418d-bd0d-ef135cd685de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135907","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:44317069-2832-48ab-91ac-17150694fece","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3860","original_object":"UniProtKB:P30968"}
{"id":"67417c48-5112-4fc5-9eba-519e1b001430","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K7G81N94DT","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:f706ebb7-c1a7-4a8e-b201-946dc29567b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2110","original_object":"UniProtKB:P21452"}
{"id":"562f38a2-461c-4c3f-a09b-0d491d606ad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164933665","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:8f66443b-c777-4119-8068-7b0a6b907cbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13944","original_object":"UniProtKB:Q8NBP7"}
{"id":"e0c0c94d-d4d3-4429-9ad9-52cad8a400f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9691","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:339fad03-7ea3-49ea-84f8-b2c7a6470d09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9691","original_object":"UniProtKB:P09619"}
{"id":"bce0716c-ddec-47b5-b82f-5b26ffafcc6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4845","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:b9dbd68a-fde0-4f11-87e4-1aa85bbab2a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4845","original_object":"UniProtKB:P16066"}
{"id":"b76a3979-58aa-4695-8822-d1affc8b2f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435286","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:5ae204aa-29b0-4148-bbed-e1af2d3185c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3353","original_object":"UniProtKB:Q13304"}
{"id":"735795f0-4a66-40b7-9062-2ca7f0ce5da4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YTL7A418KQ","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:51bbcfc5-3ae4-49c0-a32e-485df4f4b9b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8391","original_object":"UniProtKB:Q92769"}
{"id":"ff77ce0d-0654-4b06-b3eb-fc206c690724","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918513","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:3e396a40-99bb-4992-a444-72c57decd7a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12","original_object":"UniProtKB:P34969"}
{"id":"ce80498d-9a97-4091-adee-1d2f6bd2a2e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8273","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:440ebaa6-da43-452a-914a-2e76788bf724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7003","original_object":"UniProtKB:Q92831"}
{"id":"9074c159-2312-435a-89f5-39960a214ea1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68649","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:5239d6f6-799f-4b59-be89-d35feb25013e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2169","original_object":"UniProtKB:P37288"}
{"id":"974d4893-9d25-45be-b0c3-68bf98808e4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188895","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:a765ffc8-a3ae-4552-acb8-b1d19f9bd9e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:196","original_object":"UniProtKB:P14842"}
{"id":"7198e1de-78c6-4dc6-9922-4076aac04ba0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2047","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:7c920c90-7229-43e2-bde1-afebcdf5ddf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2047","original_object":"UniProtKB:P30874"}
{"id":"1dc19c94-7485-4a90-8c6b-25c38f3a162b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9T210MMZ3F","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:cd5dbe13-5bf4-4453-a7a8-5ad36a2b0485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11586","original_object":"UniProtKB:Q99720"}
{"id":"9c986db0-cd25-46db-ac9e-b879a7a93787","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N33070GI64","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:27e0c737-8691-41eb-aa02-677be5d85646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5618","original_object":"UniProtKB:P0DMS8"}
{"id":"9b470044-ad4e-4591-8513-c16ccf1cb092","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSL3FEZ1IF","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:70e0422a-9a24-421f-97b6-872fd1d58a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13108","original_object":"UniProtKB:Q07817"}
{"id":"e3ef72f5-538e-48ba-a5e9-71dcd1f61523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156077039","predicate":"biolink:affects","object":"NCBIGene:10721","sources":[{"id":"urn:uuid:81ed3815-975b-4161-8a8a-92b10972764f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12658","original_object":"UniProtKB:O75417"}
{"id":"c41989c8-28c0-45cf-bbbe-526706fdfe18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:854189","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:45b40392-3582-41c0-8b43-e67a590514b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5803","original_object":"UniProtKB:O15552"}
{"id":"71047458-817f-4157-a958-f45b4327b20f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486355","predicate":"biolink:affects","object":"NCBIGene:5045","sources":[{"id":"urn:uuid:0d3f491a-bee7-4459-a71c-005644b4cb9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6564","original_object":"UniProtKB:P09958"}
{"id":"bf64f783-383c-4047-9287-b7aac2243305","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71817810","predicate":"biolink:affects","object":"NCBIGene:4012","sources":[{"id":"urn:uuid:1764cf22-0e97-4316-b021-f0660cefe96a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8666","original_object":"UniProtKB:Q9UIQ6"}
{"id":"1285caa9-103d-412b-80a6-8bcd705a31d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10305","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:ad52687c-11a3-42c0-a508-5df27e14175d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10305","original_object":"UniProtKB:P78348"}
{"id":"4791987a-f209-46e3-aa9e-a326c43eb80e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1993","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:65cf0c72-637c-40f0-8846-7a9ea45e2e48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1993","original_object":"UniProtKB:Q9HBX9"}
{"id":"79079565-11ab-44e9-acc1-a5493133dbbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118989091","predicate":"biolink:affects","object":"NCBIGene:9097","sources":[{"id":"urn:uuid:6f444efb-c300-4814-a871-65891589c8a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9413","original_object":"UniProtKB:P54578"}
{"id":"1a0ede1c-95e9-49c1-bc34-77c6094c6a55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5275PJ1C59","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:4e8fe429-de48-4ba6-aee3-a22b025f5f98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5169","original_object":"UniProtKB:P09917"}
{"id":"688f8155-d17a-4131-8715-8071b0f4d378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:4752","sources":[{"id":"urn:uuid:59781370-73ce-49f8-91ab-0fc35fbb7ff2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:P51956"}
{"id":"7c9b7ebd-41fc-4a70-876b-26e435c9de0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755178","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:4129b00d-cc7d-46f0-bb86-5bcdce88f639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6169","original_object":"UniProtKB:Q8TDS5"}
{"id":"2ade07fe-77f6-49dd-981b-66c1d78a8082","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:79001","sources":[{"id":"urn:uuid:6b179e93-4b72-46d2-820b-22f63ab46078","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2645","original_object":"UniProtKB:Q9BQB6"}
{"id":"71d10cb3-0fff-426d-a0c1-994681451f02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BRJ718SA03","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:c0b843a8-cc95-4bf5-9764-2243b028a4f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9003","original_object":"UniProtKB:P35372"}
{"id":"2138e551-1d55-40db-aa28-f232506d80ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081964","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:9eb3c431-af46-460b-81cb-3bb5b8e1c684","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9886","original_object":"UniProtKB:Q9BWU1"}
{"id":"98109e31-8274-4ebe-9a64-61d98648a296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:a753ee60-d0f7-46d4-aaca-e68fddb0eabd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q15413"}
{"id":"5571c9ef-3712-4212-b894-f0b44abe16d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:b856b3be-2462-426d-bb46-24fdf36f9ec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P30542"}
{"id":"674433d6-bd96-48c0-9576-aa8049a10d4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92418","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:c0aca479-e846-4dcf-9503-faef798f3ac6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:295","original_object":"UniProtKB:P08172"}
{"id":"26250e96-a9b9-4589-8627-f84885f8e7b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:6ac7e601-3f27-4565-911f-62fb24a69904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P11229"}
{"id":"b0065e24-4340-4e76-80cd-dec6bea47d7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24763223","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:07a7ff6d-619a-48b8-bfad-b7bbc33dae0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8289","original_object":"UniProtKB:P48039"}
{"id":"6adcfa43-e8eb-4076-a1b5-f8c89b412f75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64156","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:d30dd84f-c311-4311-a7bc-e04f81306a9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1250","original_object":"UniProtKB:Q91ZY2"}
{"id":"3ef4548f-644a-4000-89e3-aafe5a67a65a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:e0801fc6-4a1e-4b5f-9596-c26f18eb614c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P10980"}
{"id":"778508ac-d1f7-4ec0-92b9-318edef6fef6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4615087","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:e5070222-d04d-4907-a2fd-31ce3041cf92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10295","original_object":"UniProtKB:Q9HCX4"}
{"id":"319dc2e8-19fc-45bd-88da-3caef40d6678","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817451","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:3a4aefcb-5817-45be-bb51-cf96eadb8584","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3730","original_object":"UniProtKB:P43220"}
{"id":"ccc8998b-4408-44c5-87c5-98eacfc29df9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93528","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:b03fde08-0502-4a35-8f2b-ebce7e2841f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3346","original_object":"UniProtKB:Q13255"}
{"id":"5c9bc3f6-cadc-4fd8-9df4-e10e31ce83fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:b3de17e7-8a90-4602-8e57-cc9032a7d37e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:Q9UBN7"}
{"id":"e36febcd-e6a5-47a3-b813-39fccaa33fdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCL936W835","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:8e01fccc-491e-4b2b-8673-8a2380706867","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7743","original_object":"UniProtKB:P48736"}
{"id":"947aea11-cc2c-44c7-92a7-ad0118d853ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10065953","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:5026cb21-0a1e-40a6-9271-9ec4670c0aec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1705","original_object":"UniProtKB:O43613"}
{"id":"414a9c7f-06ae-4be5-bab8-42b6fae85a2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13153","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:fb754417-0891-4b0b-9f69-57535cffa506","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13153","original_object":"UniProtKB:P35368"}
{"id":"9d5810ed-6e01-410d-a2fd-7c3a8fba8cc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114175","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:303aa584-c28d-4fd2-817e-434fbb385e5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5951","original_object":"UniProtKB:P24941"}
{"id":"ecb8df94-5eec-4ade-b2ff-075fd71a1950","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A26QO95U37","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:127bf170-b372-4166-b587-a42801a519d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9855","original_object":"UniProtKB:P25774"}
{"id":"a924fb0f-2337-4070-9cb9-5f16ccb81370","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35046","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:ce8e9e61-ad55-4dc5-89a1-7a3f9d46ca01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2596","original_object":"UniProtKB:P56696"}
{"id":"64c7392d-f1bd-4bbc-8a48-d4b07a752ebc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PUE0TO3XDR","predicate":"biolink:affects","object":"NCBIGene:462","sources":[{"id":"urn:uuid:f44ba0fc-d7f3-4b13-a07d-b1083575efe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6846","original_object":"UniProtKB:P01008"}
{"id":"fc68a15d-1836-4633-9f68-490caa563367","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2316","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:426ed619-e4c9-497f-9907-3d40de43d2fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2316","original_object":"UniProtKB:P70605"}
{"id":"2ca70288-805f-412a-8a91-274ab256e386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9985526","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:6e2ef6bb-7820-49ed-a25d-d2f50cc606ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:293","original_object":"UniProtKB:P08912"}
{"id":"56a564e5-100e-4328-a023-b95fe864d974","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:618a3fb2-5852-42f9-b075-8c4d14494c7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:P31424"}
{"id":"b9a6f43c-2795-4b15-a568-4eb0f2f32f7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O1Q96UZ63W","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:1b3b2f37-ec84-44dd-81ab-5271a09465d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3281","original_object":"UniProtKB:P29274"}
{"id":"8c75cfc8-3472-41fe-b15a-d20c7534969e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:7109e7c9-fda8-46ee-bb21-91f8d5ada181","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q9HBA0"}
{"id":"e2867cef-fb3a-455f-82bb-9f60eea5452b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90685","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:7cfa11cb-85a9-4cf4-a9d9-97532a4e09d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9915","original_object":"UniProtKB:Q16539"}
{"id":"11691efd-d2dc-437e-bceb-21dfabd6dc06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92184","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:f5e585df-8c78-4594-9f08-85c675d5bb3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11149","original_object":"UniProtKB:P34972"}
{"id":"84d16b60-a875-458b-9327-5c061412bf3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46906624","predicate":"biolink:affects","object":"NCBIGene:9201","sources":[{"id":"urn:uuid:80e04f31-a398-4705-ade0-527197829aad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8207","original_object":"UniProtKB:O15075"}
{"id":"2f78c8a8-10ab-4286-86dc-875f3edda196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73386890","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:4f08df43-c178-4369-a8d0-8c595b31fe0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12706","original_object":"UniProtKB:Q5S007"}
{"id":"2d8d7c48-438a-4a91-9571-176e3d6c58a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127029348","predicate":"biolink:affects","object":"NCBIGene:284111","sources":[{"id":"urn:uuid:4c6fea2e-0540-4034-bff0-6be9033fa7a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12849","original_object":"UniProtKB:Q86YT5"}
{"id":"dd0fcdf2-d3a6-4c0a-8043-06d1d7ac6e32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MWI54OUA12","predicate":"biolink:affects","object":"NCBIGene:10803","sources":[{"id":"urn:uuid:5f84da49-8763-40fb-9cd4-716517d9997b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9046","original_object":"UniProtKB:P51686"}
{"id":"ce2e194b-5b3b-4a98-bc63-91bfe3756e46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2229","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:1bcfac24-cc26-4839-be63-73f8760c9d35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2229","original_object":"UniProtKB:P30518"}
{"id":"a3b3847b-5587-4c6a-ae04-f7910b32e652","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4767","predicate":"biolink:affects","object":"NCBIGene:9152","sources":[{"id":"urn:uuid:b9931391-3ddf-4b38-b1b4-988bda94813c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4767","original_object":"UniProtKB:Q9Y345"}
{"id":"8971ae29-5598-4468-99d0-96da21ead526","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946717","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:aad29856-6a95-4e12-b1e6-8f3fe8b5ce22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12522","original_object":"UniProtKB:Q9HBW0"}
{"id":"61552c4e-bf5c-4505-8577-52fbdfb329d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:20dd35a8-20e1-4f8c-b648-1f1a67de90c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P30939"}
{"id":"a5ef2772-5853-45d2-a1c9-37d3f667a57a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:22066","sources":[{"id":"urn:uuid:b7e0b381-188e-4fc4-a0f5-e46f0d85ca26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:Q9QUQ5"}
{"id":"a6ffebd1-1c93-47eb-a69e-78822f31fbd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56599142","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:85f045a9-aaa1-4301-a1f0-da7d3bdd1022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7652","original_object":"UniProtKB:P14416"}
{"id":"0046499a-536a-4f2d-a902-c62765317a3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86262","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:40b71a29-0e97-46ce-8a6e-0613d38fb802","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5799","original_object":"UniProtKB:P49019"}
{"id":"8203da39-f615-4e42-9521-62fa2511c07e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:329954","sources":[{"id":"urn:uuid:f96da380-3d70-426a-9c75-81ba2e9572b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q8BVN3"}
{"id":"b56c182d-ad31-4619-aeb1-cd51cfaeaacf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9842556","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:25a0e601-087c-4b7a-b526-4bce5715c91c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6557","original_object":"UniProtKB:Q07343"}
{"id":"55798f38-ba8a-43eb-92f0-5d0c786cba03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:627","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:ceaaa753-bc6a-45cb-baea-75c2fd1593d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:627","original_object":"UniProtKB:P21729"}
{"id":"47e4536c-c8f2-4b80-a945-a756f9d48cfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817487","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:b528ad1d-eebe-4466-a612-16a7c004795e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6130","original_object":"UniProtKB:O60755"}
{"id":"1d1cab3d-bb4e-470a-ac4e-0f7c89294031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10021664","predicate":"biolink:affects","object":"NCBIGene:25302","sources":[{"id":"urn:uuid:d2ab727b-1bbe-4edb-8221-f5c75b0be4fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11383","original_object":"UniProtKB:Q05941"}
{"id":"8224b0e0-f32b-41ef-a708-b6bc00f7f5e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604758","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:c687ea84-ffcc-42d2-bdc8-f82fc9ac03c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:951","original_object":"UniProtKB:P35462"}
{"id":"e6af2116-34d1-41fe-a50a-514bc94816e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NS3988A2TC","predicate":"biolink:affects","object":"NCBIGene:4217","sources":[{"id":"urn:uuid:3e06654b-da3e-4355-8f1d-e0d3be953d21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9040","original_object":"UniProtKB:Q99683"}
{"id":"7e969ecd-3ada-4c84-88fe-f4dd44b9c295","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59393720","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:96b540b0-ba51-4321-96a5-7034ce9159d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6997","original_object":"UniProtKB:P21453"}
{"id":"d8bff6ac-837b-4d10-9218-c7d26df27fff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25149244","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:cb4c36a9-8069-47ac-b2a4-a736ee0b4e4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1199","original_object":"UniProtKB:P25021"}
{"id":"9aa13963-a90d-48c7-9855-6efab0d71605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RWS6U82B77","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:0b3a967c-ef6e-4a26-9538-1f9f2773db3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6214","original_object":"UniProtKB:Q13255"}
{"id":"8c5ba3bf-4ccd-428c-82cf-58d9f7795f89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:efca8156-1a95-41ea-adb4-e298cf094c6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P30875"}
{"id":"5904970b-3c5b-4918-8811-065956b0abc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:2048","sources":[{"id":"urn:uuid:83b444bd-40fc-4e02-a212-b94f208e35a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:P29323"}
{"id":"bbefbac9-b678-4dcf-9bfe-26e000d954b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40303","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:d1a86547-a64c-4b91-bcc3-4f3055a3bfbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2739","original_object":"UniProtKB:O75469"}
{"id":"3e1da095-9540-491e-9aa8-e36effb12b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:75cb70b3-aadc-466e-997d-85b111259fb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:P07333"}
{"id":"deeed2e1-3e1f-4433-8f80-830f480066c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13916","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:ea332892-57ff-43c0-9dfe-800c4c607e2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13916","original_object":"UniProtKB:P50750"}
{"id":"3ebb2026-a536-4b60-80ee-baf42a5f678b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1568","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:14bceb10-9f91-4c0b-9c53-45973ee75932","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1568","original_object":"UniProtKB:O95665"}
{"id":"946150ea-6c0d-4e7f-88b7-0ab198166bc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:835","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:e75bfd0b-547e-43b6-b7fa-5047984a3e6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:835","original_object":"UniProtKB:P51677"}
{"id":"1e301dd7-0ed6-41ae-bccd-2fd399c02cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:314","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:32c186d3-f0fe-405f-8441-4f2e7b7b5b4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:314","original_object":"UniProtKB:P11229"}
{"id":"2f0ad341-2071-4744-b7f3-1180b32eb922","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:895f3b17-f5b9-4645-a624-440699b110ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P25099"}
{"id":"3f640029-f0d3-4b7e-82bd-71b8a24c514b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JC77BCH2AP","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:577f4f4e-7679-43e5-a55e-707694693208","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12151","original_object":"UniProtKB:Q8TDV5"}
{"id":"33a6794a-734e-485a-aa4d-8a2f8bd52a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229800","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:00e3baf3-7d63-479b-a21e-3a36e919b8d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2882","original_object":"UniProtKB:P08235"}
{"id":"7be3bc34-8f44-4ddd-960d-4dfb61a8d4ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2219","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:ecb837e1-cf49-4139-9648-660a34c049f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2219","original_object":"UniProtKB:P37288"}
{"id":"85cfaafc-b8cc-4bdc-ade0-caf3291f7c1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:20854918","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:d1477ee2-1a33-48c3-89d6-080032b98485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8731","original_object":"UniProtKB:Q9UGN5"}
{"id":"42d3df94-d1f2-42bd-afa5-792b3efc25a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46900258","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:474ea6e1-07ae-415d-875f-24cbe4d7431b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8550","original_object":"UniProtKB:Q6V1X1"}
{"id":"836015ef-9d94-4b91-a3fc-9eb2bd53c15f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190326","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:b058f61f-3041-4ccf-9610-78c79cc9a508","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:731","original_object":"UniProtKB:P21554"}
{"id":"56145aeb-a9d1-412c-bcbc-0a668d4e3b33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32184","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:fcda56ff-f35e-48a8-ba8d-9593449e5351","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6952","original_object":"UniProtKB:P13631"}
{"id":"3dc20634-077a-443e-a76c-ae261c288ef2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1657","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:26d2e973-b08a-450f-9f62-6e4f255d0a7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1657","original_object":"UniProtKB:P33534"}
{"id":"d617625a-eee2-4d26-a8d2-67c14f9a4459","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131144","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:76bd98bb-732f-4196-9d89-39a9ca8aa12e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6623","original_object":"UniProtKB:Q9NRA0"}
{"id":"2284c6fe-becf-43fd-b0c1-dc2ce6ed8749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:f6580ebb-0a79-4a1d-8736-3ac2a0e29d8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P28335"}
{"id":"6b5f85cf-0cf9-488c-8a2f-67f5dda937a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:37afb32d-bba9-4724-9810-f98f00b5e548","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:Q9P0X4"}
{"id":"9c219b6b-b836-4f2a-81a8-8a5ac49f6e88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154616422","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:71fcacaa-ef90-4a6b-aeb0-108c45d920ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11525","original_object":"UniProtKB:P24941"}
{"id":"5f0d9daa-929b-418c-8fb8-e859725f5e45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11344","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:d56c44cc-7175-42b2-8378-1f9fa2986d3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11344","original_object":"UniProtKB:Q9P296"}
{"id":"255c863f-41e9-46f6-a2c5-cf4cc6fb1232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604712","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:4b42dd7e-e2f3-426f-88ca-eeea1cdf79ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1366","original_object":"UniProtKB:P31424"}
{"id":"42965c3b-fcab-4206-9e0d-3372360670a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R0GPP0WDF9","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:8419398c-fbfc-49b9-af8b-add05ec6161e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10202","original_object":"UniProtKB:P20272"}
{"id":"17e26cad-d5d2-492d-bcbf-c2d6426ece58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146025595","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:6be9edd9-a660-4963-9ab4-e89cc4fc6e19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10733","original_object":"UniProtKB:O15393"}
{"id":"3c8cadec-2b00-4c26-ab66-78aa7e3d8097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86H6B395PI","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:80d6f5a9-66c5-4b94-ab2c-b6c9b14dccdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1218","original_object":"UniProtKB:Q9QYN8"}
{"id":"6cb799a9-1178-4f80-833a-b75e2bec53ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996540","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:d88345e9-00f5-4767-92cd-066aad0984e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10702","original_object":"UniProtKB:P42338"}
{"id":"c94d7ea4-7580-479c-8859-ff80c7354cf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44132853","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:b3aee58d-8a28-4263-a03a-62be5f44e2b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9814","original_object":"UniProtKB:P15056"}
{"id":"955e34b5-96fc-4560-b977-bd720d9e15ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:2caf36a8-b952-4e9a-b6d7-750b81af9aa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:Q13258"}
{"id":"341a8e96-f732-4bc4-bec8-1de0b06e3dd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94717","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:40e67952-01d7-45d5-8d4c-40f6446d8148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11788","original_object":"UniProtKB:P08183"}
{"id":"f9968cef-c1a7-490c-8b20-47b7900ad02d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92070","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:ab163b93-b26d-4b0e-99ef-ced730903394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:94","original_object":"UniProtKB:P30729"}
{"id":"3bcf1590-5ab8-4d26-b2df-d17f84a9e00a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488874","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:be4dee55-c9ff-4bc1-9ca5-09b59cea0c13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9188","original_object":"UniProtKB:P34972"}
{"id":"a94a235c-9ce2-4e0d-bbf0-fb907c89dbfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:fbdf7df9-0e2d-4315-9462-4841e8626ce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P08913"}
{"id":"9a56a9c3-05ba-42d9-a8d9-7eab054a1cb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:13611","sources":[{"id":"urn:uuid:dadf0dcd-a916-4480-99cf-3872adcd406d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q9Z0L1"}
{"id":"d8e490cb-664f-4e5b-9282-0198ad0351a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8R6ETA52F","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:943a6f52-8944-4ba2-aa87-59765d558319","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12612","original_object":"UniProtKB:Q15303"}
{"id":"f9581317-ff1c-4ff5-acfd-fa8ffb91a185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15931922","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:3c102afe-d22f-465a-a214-739b43282c81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3029","original_object":"UniProtKB:P04035"}
{"id":"b0385add-45f9-453c-8279-2bb87c88c20c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2567","sources":[{"id":"urn:uuid:6d39b114-e2bc-4a03-bae8-d9c986a7190e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:Q99928"}
{"id":"96531d52-197a-438d-955d-ee6350ce4eab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679548","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:c1fd314b-400f-4f9a-9cbe-0812b69d1b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11941","original_object":"UniProtKB:P03372"}
{"id":"6fb8668f-4d2e-4a39-8588-238bb6c36b3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PV6YEC8983","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:49cdf465-70d2-40ee-b7bc-bf9a0ffdd3e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4166","original_object":"UniProtKB:P48058"}
{"id":"42f3cc12-d7f8-44c0-a4fa-c288894555ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13882","predicate":"biolink:affects","object":"NCBIGene:1509","sources":[{"id":"urn:uuid:40d2d723-01af-4148-a607-e2c43e71b3ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13882","original_object":"UniProtKB:P07339"}
{"id":"d112f27b-54f3-41c7-a307-1e538219c3bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086114","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:69226f63-d246-46e8-9fa8-f120002fcfc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1618","original_object":"UniProtKB:P41145"}
{"id":"48b441d4-8a35-4639-ad06-5d6b1c419bea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:1261","sources":[{"id":"urn:uuid:30fe0261-ccd5-4e53-91d4-70c571e73017","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:Q16281"}
{"id":"c97e250b-a5ac-4c57-bff1-c8dc5f8b03fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:48ed39ec-b2ca-4eb7-9061-c6debd4aa45b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P25099"}
{"id":"e07a2899-deee-452e-8587-8f72d6bb964d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:39af81d0-3ce5-4d1d-98e5-22534fe501d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P11362"}
{"id":"07bea0fc-d824-42de-a77f-249265485d52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:28813094-5597-42df-85d8-fe2296e81d9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9Y210"}
{"id":"b04f6020-4fa2-4c75-86ba-3f729a9e881a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25015677","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:f9822e17-8374-4e44-a9eb-ec69905da8f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9403","original_object":"UniProtKB:P53350"}
{"id":"ccdbc5e7-34a7-46fd-a33c-796228820eb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73410","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:b20be78c-dcc5-4e2a-9e49-ef4b3f64b843","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4637","original_object":"UniProtKB:P23975"}
{"id":"098e245f-974f-41ff-a84e-f586aa762fbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EJL329H95R","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:eb379b70-1e9a-4fce-975b-d6dbc9120c32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:199","original_object":"UniProtKB:P14842"}
{"id":"ddb3dd4f-2cb6-4e05-ac1a-cf69784c3f04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y6BX7BL23K","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:77fa572a-c6d0-4b5e-a393-1eaaa6de1948","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9767","original_object":"UniProtKB:P21802"}
{"id":"ebdb275e-0649-4063-8874-f13121791d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92845","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:bc2188c2-8a55-406e-986c-6147244afaf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2429","original_object":"UniProtKB:Q8R4D5"}
{"id":"136ff2bc-25c8-438f-8833-d8b6a4c6bc9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:230710","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:0cb634ad-c5f2-4b18-8321-fd1ace5ec048","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4255","original_object":"UniProtKB:Q9UBN4"}
{"id":"f543aa99-9649-4291-810a-5d0a0ebeac89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177470","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:f782519b-8744-4ad3-a2de-4d4f731d651f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1894","original_object":"UniProtKB:P43115"}
{"id":"5da93f3c-52e1-4121-8cf6-ff530d9e935c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6121","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:cf5d44ce-7db8-4f69-baa3-19601b315dab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4233","original_object":"UniProtKB:O15399"}
{"id":"eee6f309-cbc1-4524-b321-f6a500e77f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"UniProtKB:P52191","sources":[{"id":"urn:uuid:ab7b507c-bf10-406c-8f9f-264e14deed18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P52191"}
{"id":"b7aa6318-8691-4a0d-8d4e-b152efa9a73f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:72980e11-fcf9-411b-83a5-1def18de5ec6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:O15379"}
{"id":"71d8e291-2c43-48df-850b-c63f2c01af89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:61OTZ32XNC","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c82285ce-5416-4daf-8895-dff756a637c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10169","original_object":"UniProtKB:Q13258"}
{"id":"9b58a722-72f8-441a-8193-b6aeaa8fdba4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75095","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:633e4a15-2830-465f-846e-12dacc6eab7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8789","original_object":"UniProtKB:Q16678"}
{"id":"048d7fd1-3f33-44bd-a9b0-b2d0f7a77a21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6536812","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:56fb6b35-1ac8-4ea6-8575-28bfa66d13fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1964","original_object":"UniProtKB:P43252"}
{"id":"ec3dfceb-d847-47d3-8228-fc65e3831a83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46891047","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:eee96e86-0028-4b96-b70c-a154111c8839","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6212","original_object":"UniProtKB:Q13255"}
{"id":"6bb35833-2017-49ae-84d6-62d4bef34522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135673","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:afac010d-6b89-45bf-a57c-455b642dde45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10103","original_object":"UniProtKB:P35367"}
{"id":"d76bbd12-4245-4ac0-8e49-0530aab60078","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3210","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:0d4bcdc2-6f6f-4345-83f2-e574ec359fd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:144","original_object":"UniProtKB:P31388"}
{"id":"a481453b-f53a-45e6-8864-32685b17ce71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:5261","sources":[{"id":"urn:uuid:ab512b0c-57b2-4258-ada1-2629acc3b320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P15735"}
{"id":"a37aad76-0203-4dd7-94ff-333cfb832df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47785","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:748c7855-9d6d-4e3c-bf0c-3ab16813265c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2456","original_object":"UniProtKB:Q8TD43"}
{"id":"920081ad-be64-4c88-b637-6d286ee92f0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9848160","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:f32bd082-016e-41ea-88aa-f117940dfbbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9022","original_object":"UniProtKB:Q99572"}
{"id":"47948ae1-0d5b-4419-87f9-dcb2caf7c8f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6121","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:78928993-77fb-463e-bde7-861616937c81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4233","original_object":"UniProtKB:Q14957"}
{"id":"bf4a933a-8487-4ac0-b7f7-97d38ff0631c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15971","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:af481df2-f654-4109-84c5-6973498347cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3310","original_object":"UniProtKB:Q9ULX7"}
{"id":"0bc32912-74d5-4950-a01a-4a65c18335e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:66VRX9TN9T","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:0d4170c9-2054-4b4d-93bd-533f3a7be713","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12784","original_object":"UniProtKB:P30968"}
{"id":"6f470d6e-600e-41f0-806c-ea184bd3e618","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104895","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:80e945a7-9211-4cf9-b163-5197861c7f85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:730","original_object":"UniProtKB:P34972"}
{"id":"4cf355db-9ba8-44f3-bca6-a0a5274e2c69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2ZL2BA06FU","predicate":"biolink:affects","object":"NCBIGene:3615","sources":[{"id":"urn:uuid:37857aed-0867-4831-83ff-b53bd05868ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10741","original_object":"UniProtKB:P12268"}
{"id":"e1c1b5b1-ab84-4741-a656-e2f167e74506","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53868701","predicate":"biolink:affects","object":"NCBIGene:56341","sources":[{"id":"urn:uuid:a750aae2-2408-4194-8252-af53a8d6fd2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9529","original_object":"UniProtKB:Q9NR22"}
{"id":"ed806662-6dea-4026-ab0f-11ac51f97121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228145","predicate":"biolink:affects","object":"NCBIGene:57104","sources":[{"id":"urn:uuid:1743141b-9953-46b1-b047-49c5b840b2e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12995","original_object":"UniProtKB:Q96AD5"}
{"id":"af9d474e-d94d-4019-983a-9262935cd0d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3981","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:07848eb5-3605-4204-b191-a6a604aada77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3981","original_object":"UniProtKB:P36544"}
{"id":"2495691d-73f2-457f-8bbd-a2c2216fc5d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13547416","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:60d6ca53-1617-4b44-9069-51894a79bd87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:169","original_object":"UniProtKB:P14842"}
{"id":"93f7f603-4b77-4dce-8d90-da58da62abfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433295","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:cca2bcd1-d1c8-405f-a811-66477ed30f88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12670","original_object":"UniProtKB:P45452"}
{"id":"f2b3968c-64f8-412b-85dd-1eb3bd14ee5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9445","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:059d1686-3bf1-4443-8e60-66d5c090054b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7302","original_object":"UniProtKB:P25100"}
{"id":"ff355c84-36c9-4bdb-bafb-91a575369e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156821173","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:a4d89e0d-4b6c-4bbd-9080-80cd6cb7b1db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12164","original_object":"UniProtKB:P00533"}
{"id":"9e4438ab-e557-4b32-9408-22d2ef4d86a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94742","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:c60caca0-71ac-4422-ba05-c358ed253001","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9361","original_object":"UniProtKB:P42345"}
{"id":"038d3e3c-ed45-4f66-a8c5-b0a9dbf5719d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10428048","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:6961a4bb-b465-4e8d-92d2-7f49ee6e6499","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3955","original_object":"UniProtKB:P31421"}
{"id":"92ceace4-701c-4af9-8ce1-e51f90bc13db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34879","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:d4e5568f-ec36-436d-be72-3d460729a0f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4272","original_object":"UniProtKB:Q12791"}
{"id":"22a9d412-6728-49ff-8102-bca74a65909b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92288","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:96d985aa-b4e7-4c0a-b4d4-7e2f8183b0ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:258","original_object":"UniProtKB:Q62758"}
{"id":"42bd071b-a74d-429b-be4d-6f4175b50dc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2063","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:4077309d-907d-432c-a799-a0fe185adb7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2063","original_object":"UniProtKB:P32745"}
{"id":"1767c01a-e24e-413d-a97f-10af32213a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59773","predicate":"biolink:affects","object":"NCBIGene:50837","sources":[{"id":"urn:uuid:f75d9ca9-84b5-40bd-b42a-2513049f73a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7608","original_object":"UniProtKB:Q9NYW3"}
{"id":"5bd55ea5-b21f-48f4-a9a2-35acc7ad59a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KL2Z2TLF01","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:ec94850d-7e92-4a97-b30c-1c0f7a790cac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5933","original_object":"UniProtKB:P52333"}
{"id":"b8197056-d428-47b6-932f-31cc8d23efa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22991950","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:ac0d55e0-0991-407a-bab7-82714632b17c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:326","original_object":"UniProtKB:P08912"}
{"id":"6f6e3e76-e6f1-47d5-8ade-d7af22c8355e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3750","sources":[{"id":"urn:uuid:18b5cbb0-d4b8-4519-a019-247369226f59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q9NSA2"}
{"id":"485e6e4b-728c-4afc-bafc-6730e7ec3c8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92119","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:490710c4-f2f2-4133-8c8d-a223103ca4a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5952","original_object":"UniProtKB:P11802"}
{"id":"ea640302-7e13-497e-9dd0-0f7c0d191bf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1008","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:8e84a812-2b51-468c-aeee-a0b9ce7c3362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1008","original_object":"UniProtKB:P24530"}
{"id":"998ec033-730f-4eb8-b4fa-5fc464f46a0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947029","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:77dc956c-4869-4947-bc2c-84097562d8ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3001","original_object":"UniProtKB:P04035"}
{"id":"84560cf4-0376-4fc9-b4d4-3efae6215e14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6534740","predicate":"biolink:affects","object":"NCBIGene:26191","sources":[{"id":"urn:uuid:b2dd37fe-3a66-4f92-93f4-707a639b9312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10373","original_object":"UniProtKB:Q9Y2R2"}
{"id":"7d2f6f55-1776-4d69-a26c-bc3a3e19c768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49375","predicate":"biolink:affects","object":"NCBIGene:23235","sources":[{"id":"urn:uuid:d6868e1b-a5d2-44a4-8f95-5dfab97d9b1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5678","original_object":"UniProtKB:Q9H0K1"}
{"id":"e486ab94-ebbc-4882-80eb-ef0eb3ddbc7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:cb414d58-4733-43bd-9655-ab11f7a1c60b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q8NER1"}
{"id":"d89b25a9-e4a5-4cda-bf36-7e38890d70cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4650","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:7ecfdb2f-ce13-43b9-956f-4de70af1ead2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1617","original_object":"UniProtKB:P41145"}
{"id":"9409a0cb-de2f-403a-96aa-05befe7aea3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1048","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:d188ff08-b649-4ddd-b8db-64c7d8ed5b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1048","original_object":"UniProtKB:P25090"}
{"id":"9df668ec-b3d2-4465-906f-94a8cdced986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2180","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:0f82cfbb-03bd-471d-8795-6e4c9cf29897","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12451","original_object":"UniProtKB:Q9NYV7"}
{"id":"51fb900f-bf25-47e1-b17b-7adf69ac7bad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27999","predicate":"biolink:affects","object":"NCBIGene:83535","sources":[{"id":"urn:uuid:6f65ee9c-a663-4faa-80b2-f9aaee5341bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6848","original_object":"UniProtKB:P70673"}
{"id":"93ba0328-35a7-47bb-9a32-18449b26d81f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11531","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:fb9011b4-e9d5-462f-8603-1883cf3b2f01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11531","original_object":"UniProtKB:P13612"}
{"id":"a865b6e5-68c3-4911-98cc-dbdd89e4698e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZC6062V1O9","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:8ebe35d0-108b-459a-a661-bd7dc77ef3d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2640","original_object":"UniProtKB:P13631"}
{"id":"a50e52de-8241-499f-8779-74b25af97053","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149519","predicate":"biolink:affects","object":"NCBIGene:6597","sources":[{"id":"urn:uuid:b8da2e46-840f-4d02-9cf3-c152842ae5f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7915","original_object":"UniProtKB:P51532"}
{"id":"edf72093-8cb1-457d-bec6-a2b449a71a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6EJV1J6Y0","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:3982cb97-c6c3-4301-89e1-1c00fb2d2385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12287","original_object":"UniProtKB:Q07869"}
{"id":"5ca9cd75-db35-4e49-8a24-5dc1a7dfbf3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2705","sources":[{"id":"urn:uuid:6e526f42-cee0-4321-b526-0daeef2d7d7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P08034"}
{"id":"ca06e3ec-1c3d-49d1-b44c-67eb68ba1d6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24952929","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:a46e9663-dc68-4b38-ac55-9a20f6f1a2bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4041","original_object":"UniProtKB:P35408"}
{"id":"25bcbf64-21a2-4da8-816d-30e67e062035","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135756","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:f4fb07cc-fc3d-428c-b4a9-8cde8ecaf193","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6575","original_object":"UniProtKB:P12821"}
{"id":"b958f255-3867-4361-a41b-dab6d2cf089f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:dbc84504-6715-414a-bdb5-0e3d8b891ea1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P23975"}
{"id":"7d156e24-a691-47cd-9c9f-134e43864e74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827346","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ccce7664-0d87-47dd-8016-7f5750a38dc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5622","original_object":"UniProtKB:P0DMS8"}
{"id":"bc0dfad0-d9eb-4d39-b8b2-7b271615cca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2354","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:2181a526-6abc-421b-a223-c5b66f157443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2354","original_object":"UniProtKB:Q00195"}
{"id":"dd723efe-c491-4cdf-a699-97649e748af6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72603","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:b2073ed9-8809-4247-8f63-856948e62b85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1900","original_object":"UniProtKB:Q9Z2J6"}
{"id":"051f9bbb-9737-49e3-8cf3-2aef622940d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LDJ89SS0YG","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:f088b49c-ea40-40b5-88f6-63395550ba67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12298","original_object":"UniProtKB:P11836"}
{"id":"f4c2fd37-1c72-4e28-9096-ad7b9b6feddd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131165","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:57b63770-3c92-4557-9dc0-b00820598eec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7943","original_object":"UniProtKB:P24941"}
{"id":"c2bcd5c7-eef6-427a-9b3e-a013bd6a2801","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:a1668496-7eef-4b8e-8fba-5f51a98da4c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:A8MPY1"}
{"id":"3605a8f0-bdc6-47c7-a013-ca6a3e019491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131007","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:3ce81eb0-9c20-456d-823b-14a0346e3bfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2484","original_object":"UniProtKB:O35433"}
{"id":"0dd3a8c7-186c-43ee-bc0f-23e0ff564ef8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110187","predicate":"biolink:affects","object":"NCBIGene:121278","sources":[{"id":"urn:uuid:8086596a-5a18-4ab2-8428-9fcd6628b182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5240","original_object":"UniProtKB:Q8IWU9"}
{"id":"f6c4e81d-3159-478d-a885-3725b65cff01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11770","predicate":"biolink:affects","object":"NCBIGene:3597","sources":[{"id":"urn:uuid:e077557c-9142-4cf4-8678-8c2681ea1f28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11770","original_object":"UniProtKB:P78552"}
{"id":"f21a92fb-d7c1-47db-86ef-55eb86ee5c17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DFS3SIU1ME","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:5e91bbb7-5018-4b02-9a16-1bd2cb365547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1374","original_object":"UniProtKB:P31421"}
{"id":"028e7e08-935d-4c4a-903a-61c466cb5caf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17053","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:3121939d-6faf-423b-ac3d-db3335a4c897","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3309","original_object":"UniProtKB:Q12879"}
{"id":"21b8c9ca-90ea-4a3c-9d03-8910821ee534","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:e4886e67-79ac-42eb-8172-8047e94c1d85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P23975"}
{"id":"7068f1a9-1b90-44e0-9c3c-41c9084d64d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89420683","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:51cafac6-8263-4e4c-be52-35882c147459","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10098","original_object":"UniProtKB:O00329"}
{"id":"89c1bc7b-56ea-497c-9578-dbebe096483c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MTD2HMA6LY","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:ed7e7dd2-aa3f-4ac2-83a6-cc05551ba5b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1409","original_object":"UniProtKB:Q14833"}
{"id":"8763cdf5-625c-4c4f-8792-1895be59a5ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9352","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:a10d6810-fabd-4cba-9783-c3f09bac8929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5425","original_object":"UniProtKB:P35354"}
{"id":"cb3e5722-9484-4f6f-be2a-b8aba33f363b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91108","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:15af5768-0605-42bb-b404-cc5d1a3250a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8216","original_object":"UniProtKB:P36897"}
{"id":"a87c60ee-a7cf-4260-8e19-5a779b95f36b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15940","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:fb2e3d6a-b98a-4c8e-9c15-ed105a04fb82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1588","original_object":"UniProtKB:Q8TDS4"}
{"id":"84e57678-59e6-4656-b863-5d45204f87f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4RA0KN46E0","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:07492d28-25fd-4f5e-af7c-d1d10954ef6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9246","original_object":"UniProtKB:O60674"}
{"id":"91274be0-7535-4b6f-8af5-6809c8b5dee9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2053","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:965e9089-9e86-488d-ae93-28fd6f683bab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2053","original_object":"UniProtKB:P35346"}
{"id":"065504ef-c03b-4a2e-ac0d-63cf13b57c9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:52266f6f-e68f-4508-9be6-c3d4bcf6c916","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:Q60614"}
{"id":"eb68ef57-2a86-4ad6-b3b4-49046ce47890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44472568","predicate":"biolink:affects","object":"NCBIGene:140493","sources":[{"id":"urn:uuid:08a1a8f2-f2db-4d46-92b1-1cefd235f1f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9316","original_object":"UniProtKB:P58391"}
{"id":"1904b41f-38c1-483d-80f7-0fa4bfbab160","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16086422","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:70d5de0e-d4db-4c8c-971d-1cb53bb8aab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7977","original_object":"UniProtKB:O95749"}
{"id":"6cf23622-7656-40a7-9bf0-52ce4dc4eb30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755189","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:7c03cd59-9b00-443c-b5b5-2c4a02f661f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6208","original_object":"UniProtKB:P23385"}
{"id":"0bd15b41-f776-43dd-9028-0090773878de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9927764","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:ea990b66-990d-4517-a68c-8440bdcb50e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4301","original_object":"UniProtKB:P31644"}
{"id":"f3ab8922-8a4a-4ed7-ab6f-84b1a158bd51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:304827","sources":[{"id":"urn:uuid:bfb017a3-c514-476e-8e42-d49f003ba4fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2340","original_object":"UniProtKB:Q6UVM4"}
{"id":"4cc779e1-9fa2-43e5-9519-a1dcdf7f402c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4525203","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:276f45c8-2bc9-4257-b0c4-1eb713d27851","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10579","original_object":"UniProtKB:P10275"}
{"id":"9ee8762e-fd32-40ac-92fa-6621a19f269b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1123","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:0e2a4d1a-90de-43dc-8f8d-0bea3c99884b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1123","original_object":"UniProtKB:Q02644"}
{"id":"a8374ee9-813a-4c6f-bd7e-869103712980","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7897","predicate":"biolink:affects","object":"NCBIGene:5646","sources":[{"id":"urn:uuid:515bc9b5-2d30-457e-b333-11162122c57a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7897","original_object":"UniProtKB:P35030"}
{"id":"6ac764a8-558f-493f-ac80-7bc1f65bc089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63452","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:fe7c7395-2f69-4f07-a649-e8385f4098a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5702","original_object":"UniProtKB:P36888"}
{"id":"a5ff2c45-4f3b-40ce-a06d-79b2bd1d6a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9913085","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:a08a7368-90c8-4efc-888b-66103a3dfcd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:796","original_object":"UniProtKB:P51677"}
{"id":"13b05e15-02cb-4532-8cc4-88f925e8f7cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231087","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:b72abcb7-b336-40e7-8319-7567a92e2941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9626","original_object":"UniProtKB:P50613"}
{"id":"cdafe725-15f2-479f-a195-748d70ebe24f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:26576","sources":[{"id":"urn:uuid:dcbc0ead-ad1b-401b-b44f-8bd62c5a5d4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:Q9UPE1"}
{"id":"14002273-0a39-45fb-a2af-4c5e58c00fcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11362035","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:f3efbb88-a14e-4e54-9fce-348062831641","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6328","original_object":"UniProtKB:P31421"}
{"id":"2945f4d2-e7a1-42a9-83d4-542a73bcf065","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173077","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:94488225-7d33-44e0-9012-53f4dcc5a263","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7875","original_object":"UniProtKB:P42345"}
{"id":"65861ed1-b4e2-464e-922c-6501eef263ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57521365","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:6d755dbe-f010-460d-8355-509d5aa7f9cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8587","original_object":"UniProtKB:Q99705"}
{"id":"c4102453-7552-427b-abed-11e66dd82985","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59004159","predicate":"biolink:affects","object":"NCBIGene:25153","sources":[{"id":"urn:uuid:f0338077-adf7-452a-b82a-93b67b3297f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7042","original_object":"UniProtKB:P12526"}
{"id":"4ecdad98-25b7-4ede-84e1-f07c6916deb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:5153","sources":[{"id":"urn:uuid:2afb82ce-e072-4afc-9f85-f5afb8c24280","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2351","original_object":"UniProtKB:Q01064"}
{"id":"a9c0262f-79d8-4abc-9468-34ed596d1170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:475b5633-b61f-423f-a275-f88fd5da83d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P35349"}
{"id":"45eaa058-34df-466f-8a72-45db697a5ae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135721976","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:528bc9cf-58e8-4f90-adfa-352c0bc6bbe0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11917","original_object":"UniProtKB:Q8TDU9"}
{"id":"b7ca2207-2e7c-48f5-8859-618bd567811e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:b98fab7c-9386-4483-8e66-c5df4f3cfcdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P32215"}
{"id":"b96cfaee-8e6b-48b0-8c8d-cad1aa1057d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95015","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:9bd35f32-9b28-462f-a244-4c2247fd18ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5207","original_object":"UniProtKB:Q99685"}
{"id":"b5b89045-8778-4f96-8d73-885ac4726495","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73602831","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:4d142cab-30bb-43c9-ab5d-187d937fd345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9454","original_object":"UniProtKB:Q13177"}
{"id":"c0a03b18-760b-4142-bb35-7e47968fe155","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1VI94C980K","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:eafb5263-b16a-455b-b8a4-c00d94fe6059","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8470","original_object":"UniProtKB:Q8TDS4"}
{"id":"1b462eb9-be4d-46fd-aba6-2d1896f988ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1801","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:8bbb2443-2021-4be0-8b3b-eeb1da8fb02e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1801","original_object":"UniProtKB:Q03431"}
{"id":"f50becb9-a739-41a1-baf2-4130ac8c1e87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65349","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:94bb52c4-c304-4bd3-b6bb-d75918f07ba5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7445","original_object":"UniProtKB:P13945"}
{"id":"6773440e-5fd2-4c13-96ce-ce9c76fd753f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2251","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:b5e492c3-b069-4fda-a7f5-4bbeb3721927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2251","original_object":"UniProtKB:P30559"}
{"id":"37c70cae-27da-42a2-b34e-87c977dd03b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:99GS5XTB51","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:b50d2276-0b4c-4d86-8226-8f1b45132550","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9696","original_object":"UniProtKB:P23458"}
{"id":"77367b6d-d5fb-4454-95a7-53b674c5db8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233446","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:1e448ef0-73d0-4b72-be5a-bbe1a53b6b9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12630","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"7f7940e9-0be8-4548-ad20-5299cda46764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6198","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:dc4c517a-7396-4331-b28b-3b7554c580a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6198","original_object":"UniProtKB:P25090"}
{"id":"e835296a-c9a9-440c-a596-27823f089eaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122199235","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:da81dd6b-af41-4209-9b19-3cd424d82cb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13506","original_object":"UniProtKB:Q13822"}
{"id":"67941c66-cbd9-4b07-9461-bd51eae5f919","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030533","predicate":"biolink:affects","object":"NCBIGene:2494","sources":[{"id":"urn:uuid:2ebb1ee5-78d6-4d5f-ab80-21ce0f237495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10484","original_object":"UniProtKB:O00482"}
{"id":"cec9373a-c451-4a49-ab28-b5fc1c229a0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:ed0d2a08-1637-4917-a734-2458688905b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P31388"}
{"id":"0ffe3cdf-193b-4c25-b757-45ce4089cd61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138454799","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:0262a63d-63bc-4242-a280-f76f615a34ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10565","original_object":"UniProtKB:P03372"}
{"id":"ba4ba807-ea8f-41fb-b550-7ac8e90db879","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40SGR63TGL","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:1343b6f2-d385-4827-8a7f-abbfa4cf4c29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3164","original_object":"UniProtKB:O95749"}
{"id":"6acce464-ea86-4aa2-90b7-f93220c99227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7553","predicate":"biolink:affects","object":"NCBIGene:57582","sources":[{"id":"urn:uuid:dfdeb4d1-b711-460a-a884-7ac0e5de5acf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8494","original_object":"UniProtKB:Q5JUK3"}
{"id":"b3e1a04e-f926-451c-adf0-c960e97f1a34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9934870","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:53e53882-53a6-408c-9219-8619df270dc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3426","original_object":"UniProtKB:P25105"}
{"id":"c3c09111-994d-45db-89bc-6d05d3aabb6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1HLS600135","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:ee3252b1-8e40-4b2d-848a-e4b5471e1345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:489","original_object":"UniProtKB:P35348"}
{"id":"0b03529a-2f44-476b-a33d-cb51eb87578c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4514","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:575148b5-506b-4fe0-8634-74dbc402b46e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:355","original_object":"UniProtKB:P08173"}
{"id":"ed04ae25-d9ae-4296-ac2f-9116041822f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92174","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:2408d958-ccbe-4c5a-b14a-11c76e893fab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:333","original_object":"UniProtKB:P08482"}
{"id":"7def6540-d36a-4db7-90a7-b508d385822b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146637574","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:24f316bb-b7db-400a-a0f0-e2455f908ddf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13958","original_object":"UniProtKB:Q9NRM7"}
{"id":"3fd39282-2ee3-43be-b47f-8636c24953a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1546","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:ee2365cb-86d9-4fbd-b3e7-bdd0cf634bd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1546","original_object":"UniProtKB:P25929"}
{"id":"c0fa7d42-a5d0-4f17-bc12-08018c33d957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11232124","predicate":"biolink:affects","object":"NCBIGene:29952","sources":[{"id":"urn:uuid:0f2794b5-1623-4085-8370-c3e95dc35d6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6538","original_object":"UniProtKB:Q9UHL4"}
{"id":"85c1c715-b8bf-4c3f-80b7-91b22ecc0f91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2902","predicate":"biolink:affects","object":"NCBIGene:57007","sources":[{"id":"urn:uuid:ad1a0d70-9d98-4a26-980e-e79997ddeaa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2902","original_object":"UniProtKB:P25106"}
{"id":"3febb256-54a5-4797-89dd-329ab80a4f03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91495","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:1f1b3f65-e4bd-4efb-a312-43d493bd659b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:325","original_object":"UniProtKB:P08172"}
{"id":"cbbf8a59-ee20-4503-a423-cf4a3ff28f60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3B974D670O","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:f55883ee-3f49-4f86-8202-7ebabbdc331c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8910","original_object":"UniProtKB:O75116"}
{"id":"024de02b-30b4-4dfd-9048-e19cad2a4978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:380F68J5PH","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:78c0e3fc-f98b-4f08-982f-792499704d9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11185","original_object":"UniProtKB:P41597"}
{"id":"8eca56ec-a48a-4ecb-b7a7-d94c353e167b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HB4QD9GL6F","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:5c43a013-4f65-497e-8caf-92c2523392f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1607","original_object":"UniProtKB:P35372"}
{"id":"a4f7921e-8955-4d51-8d88-52ae9e43dc7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XZ73ATU8W7","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:533dcbec-eb0e-4f5d-b6e8-1243621485a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5950","original_object":"UniProtKB:P06493"}
{"id":"b804ec47-b006-462d-b227-9f28fe9d3baf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:681569","predicate":"biolink:affects","object":"NCBIGene:6241","sources":[{"id":"urn:uuid:d148fe39-97be-4890-9e02-ba429929fd5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6802","original_object":"UniProtKB:P31350"}
{"id":"573a4527-209e-4f26-91f7-3703dcc82353","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:c045e350-2f7a-4fd9-903c-16e6b4e3bbc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P47898"}
{"id":"9e681438-7ada-48cd-b1bb-950dca271ff5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136040","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:c4384afc-fcdf-4f0a-aae1-7be6d89dcb3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7435","original_object":"UniProtKB:Q01959"}
{"id":"494682e2-9dd9-4776-9e96-43b00235d2e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53358901","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:00f153e9-1a42-4aec-aab7-797d13f471f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5514","original_object":"UniProtKB:Q9BXA5"}
{"id":"fe3d898b-ad1d-435f-81a8-86a77c089317","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FOF5155FMZ","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:c95d5d96-f421-4a53-8480-05c75f5fab48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9563","original_object":"UniProtKB:P42338"}
{"id":"29c6f901-b0bd-4cfa-a2f1-eb0d3fe16d7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QJ8RO3296G","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:ef0bfeff-d63e-4ab0-80a5-40c57b01fafd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11879","original_object":"UniProtKB:Q00534"}
{"id":"410e1c14-ea5c-4390-9ad3-6af83ebda7f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45863","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:f5d115e3-fb32-4793-babf-608b798ce7fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2770","original_object":"UniProtKB:O75469"}
{"id":"ba83234c-35fc-43ed-8caa-4c8219933b9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6133","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:5e730636-ed47-457b-abde-f8361156d1f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6133","original_object":"UniProtKB:O08726"}
{"id":"68d67d2c-08b4-4572-a52b-79bae94b2435","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16243","predicate":"biolink:affects","object":"UniProtKB:P21588","sources":[{"id":"urn:uuid:2ad3b974-8c19-413a-9a08-f0cee027b287","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5346","original_object":"UniProtKB:P21588"}
{"id":"0a5ecb03-ea71-4d83-a00f-de17b2f11ece","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92749","predicate":"biolink:affects","object":"NCBIGene:8569","sources":[{"id":"urn:uuid:08b438eb-01e6-401e-8f9b-5a7327c759f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6010","original_object":"UniProtKB:Q9BUB5"}
{"id":"2d280881-b507-49f1-a72b-c9a2de173cd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54440733","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:d8ec0971-d83e-4306-82dc-e9b0535f1f0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7677","original_object":"UniProtKB:Q12809"}
{"id":"627f0c35-2298-4836-bd77-8693eea64aa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3BY9Z3M34G","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:9be6e6dc-e40d-44e4-bb96-d9fdf6271266","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10744","original_object":"UniProtKB:O60674"}
{"id":"b8b3f432-695c-4333-986a-c05d88a8f922","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LG47VG1ID","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:175f21af-5bf6-4ef6-897d-579c7749ab55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:380","original_object":"UniProtKB:P29275"}
{"id":"332edb02-e6d9-415c-bd89-9edab23c01c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41922","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:7ac183d1-f77a-4e4d-8769-9ec56d75e776","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2801","original_object":"UniProtKB:Q92731"}
{"id":"29f89673-ac46-426f-aff4-5bbe763dae83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7570","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:d3355f9f-b4eb-4ac7-9c40-cb8f2173a0c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7570","original_object":"UniProtKB:Q99250"}
{"id":"9311e522-25c7-483f-91d6-0605fcf58555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:e9a98dfe-1c46-49b6-a943-348cf2802637","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q8NHX9"}
{"id":"a376719e-a6ce-4973-a97e-23e077faa8b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144672","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:28256714-24e5-4007-ad95-3f05e1664cf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11060","original_object":"UniProtKB:P52333"}
{"id":"79196595-38b0-43ca-8b48-c7e4b1af2ecf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92079","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:318872aa-842d-40f9-925d-001a47a07b27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2131","original_object":"UniProtKB:P29371"}
{"id":"3a2ea080-4a85-44c3-9000-b0c886252878","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64139","predicate":"biolink:affects","object":"NCBIGene:5138","sources":[{"id":"urn:uuid:4944fafe-c75b-4312-957c-3481366a1e49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5179","original_object":"UniProtKB:O00408"}
{"id":"898f0c5f-b605-4752-a829-4358537b0f7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439091","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:f22fc459-9b6d-4c85-aca9-6eb0d7011488","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5606","original_object":"UniProtKB:P29275"}
{"id":"7a8b5290-e218-4130-b6dd-f54389c206df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122192250","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:0590f234-5ce0-4efb-8030-35f5048e1a54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10277","original_object":"UniProtKB:O43614"}
{"id":"ddd24072-4cd5-4daf-a271-09949f11aad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22660592","predicate":"biolink:affects","object":"NCBIGene:4924","sources":[{"id":"urn:uuid:20e18eac-fa83-435e-804f-fe604359e1e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8515","original_object":"UniProtKB:Q02818"}
{"id":"8779f8d5-ee6b-482f-b23a-c81c3de52ec4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:d330c6b3-7046-4810-9870-a05b2b9cf019","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:P51813"}
{"id":"e6d89621-f9b9-4223-9f42-1629766cd860","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:1dfd2a31-3284-47c2-bee1-c6355c56aca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:Q5XXA6"}
{"id":"7b68966b-b37e-4267-8973-e452dc367db6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358908","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:49b486ff-7a8c-479a-8de8-3e1e1be65177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:344","original_object":"UniProtKB:P08912"}
{"id":"5c7f13e8-7f77-4bd2-8d11-111f9b05008c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:449237f7-83e9-4fcd-9e40-98f9769d45c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:Q62758"}
{"id":"b4bd54d1-24ca-40d1-aa4b-5bb0f56df903","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78426198","predicate":"biolink:affects","object":"NCBIGene:5476","sources":[{"id":"urn:uuid:21722e97-4c6e-4dbc-8f63-6cdd80f2b6b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7892","original_object":"UniProtKB:P10619"}
{"id":"ed5a5668-d749-48a8-aadf-1086bf5402f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4822","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:3935cdb7-10d9-4324-aa47-0cf29166474b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:148","original_object":"UniProtKB:P28566"}
{"id":"514ed275-deba-413c-bef0-5b1ccb617b9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X05U0N2RCO","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:afeb97c1-ff54-4a18-8cc5-cf65cba5c22c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10439","original_object":"UniProtKB:P10275"}
{"id":"7f2b58fd-a0ed-436b-bc64-de79e3a3e174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8499","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:47858606-a61e-46ec-85cd-05f2a1905ef3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:564","original_object":"UniProtKB:P26255"}
{"id":"4cfb3922-1587-40c1-8316-eb31aff57f35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:0877afc7-4643-4343-a908-c4d1c7d2ce1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8593","original_object":"UniProtKB:P08912"}
{"id":"d723a530-410e-41ef-b50f-2ec160114394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1680","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:299be375-35fa-4e51-b82c-758600a42607","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1680","original_object":"UniProtKB:P41146"}
{"id":"93d2adb8-53d2-4450-b196-f1889fcb2833","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180499","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:44089e6d-6dec-47c8-ae6e-113b9fdb305a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6003","original_object":"UniProtKB:P06239"}
{"id":"fc8d15f5-165c-4350-a276-e021507030fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10475082","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:743b4624-f70b-46b8-b439-7d71d3a9e19a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5591","original_object":"UniProtKB:P28647"}
{"id":"3b7a3cf4-faed-43dc-8374-761e7d3eff12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:770140J08A","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:7b515430-0f0d-4db9-9a67-ac7b010a22cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11153","original_object":"UniProtKB:P29274"}
{"id":"868d9e54-5cfa-4e88-ad9e-7bb7febc1963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C2M78A9V6Z","predicate":"biolink:affects","object":"NCBIGene:5972","sources":[{"id":"urn:uuid:137673f6-7087-4ced-9959-7811ba8b1abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12196","original_object":"UniProtKB:P00797"}
{"id":"97c1a84d-b64c-47b2-a018-74c65939768d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44415771","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:e1117306-64ef-4885-b1b7-e383c165d7c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1747","original_object":"UniProtKB:Q15077"}
{"id":"5d67a3b2-5d4e-4f80-93eb-d23e2e3a5c8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:509070","predicate":"biolink:affects","object":"NCBIGene:7398","sources":[{"id":"urn:uuid:fb293bcc-9afd-4930-b811-8dc81b945227","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12225","original_object":"UniProtKB:O94782"}
{"id":"c5e7ef42-d8db-43a5-bdc7-d0e8f8f75bf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z25PJ77W7V","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:ce8b9c35-d72e-45b2-95ef-e1a42b8cbfe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:716","original_object":"UniProtKB:P31424"}
{"id":"5fee718b-71b3-46b5-934d-f8de7d9adb99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F64QU97QCR","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:87590a3a-558e-49a8-aadd-16f1db808046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4172","original_object":"UniProtKB:Q15413"}
{"id":"0f6c42e3-15fe-43ca-b488-68533dfbdaa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:5070dcc8-601c-4e0e-bb5f-ea06e032ccc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P08909"}
{"id":"4db76af8-5eae-4c52-9152-f15ef3bafc2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611898","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:a2d27648-a76d-4fa5-ac01-48ca5a679ef6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10002","original_object":"UniProtKB:P37231"}
{"id":"98d70615-5285-4b15-af6e-242b0df6d586","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1517","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:b1efd226-b381-4436-b07d-445825242ecc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1517","original_object":"UniProtKB:P21555"}
{"id":"8994c052-2f21-4f87-8750-ebcfdc01d964","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43876","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:f59614c6-7882-439e-aa91-c52c7da3f28f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1373","original_object":"UniProtKB:P23385"}
{"id":"8c1ad931-19f6-4da2-ba65-2bea5988db0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71506874","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:9a374b8c-4c92-4365-8177-7800cf2f453c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12092","original_object":"UniProtKB:Q9UM73"}
{"id":"bd6fcd4f-40c1-41ab-9c2f-ed0f9f9eecaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93152","predicate":"biolink:affects","object":"NCBIGene:83633","sources":[{"id":"urn:uuid:9e348605-6186-4f94-91e5-4c22eb176e65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1079","original_object":"UniProtKB:O88871"}
{"id":"52f3cdd4-3bf6-4cc7-a013-4cd3d5994a55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N65WC8PXDD","predicate":"biolink:affects","object":"NCBIGene:330","sources":[{"id":"urn:uuid:d41ffecb-4c11-4e7c-8676-8e8291b2db91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7729","original_object":"UniProtKB:Q13489"}
{"id":"a77322ee-b95e-41c9-8950-63622c0777cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:10db512c-d0fd-475b-a73c-32c6554f17fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:P29274"}
{"id":"90f32d97-b763-4bc5-bfff-77e3e25b9a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34541","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:9e3e9a4d-a376-4b7c-aaae-0988fa46b46b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4138","original_object":"UniProtKB:P42262"}
{"id":"7e4c2526-e7a6-4915-90c2-10c9aaa6b727","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13458","predicate":"biolink:affects","object":"NCBIGene:164656","sources":[{"id":"urn:uuid:c55218c6-db8f-41ea-b188-a38e7ce53009","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13458","original_object":"UniProtKB:Q8IU80"}
{"id":"6edc2948-b196-431e-bd43-2a24da57266b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129665","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:5d141ef9-314f-44a6-b80c-f5224fb695b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1155","original_object":"UniProtKB:P23811"}
{"id":"adc63ba4-4871-4cbb-a244-01f7f3510bcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9823180","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:67212238-412b-4764-b9c2-6e1ed433e7f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3987","original_object":"UniProtKB:P43681"}
{"id":"2d034a44-68cd-4233-b1d8-d173bfeea51e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1102","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:af0ecc57-3126-4bc9-ae78-2e141f6b5b4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1102","original_object":"UniProtKB:Q92847"}
{"id":"ed68ca14-8529-4e13-b707-429f0993b357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCG5PW623C","predicate":"biolink:affects","object":"NCBIGene:309212","sources":[{"id":"urn:uuid:bcaa9ae5-5a28-4cbc-a3e4-ae6ee78cba9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10170","original_object":"UniProtKB:Q6XKD3"}
{"id":"31fb1667-87f1-4224-8578-be7ca2ef2e17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:4a6dbff0-337a-4517-a0bc-6dcb4d071647","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:O94759"}
{"id":"d67143ed-52ab-46cc-9032-24ad5ada0d3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117923261","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:aaeb66f2-02ff-460d-9d07-864326f0aaef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9237","original_object":"UniProtKB:P21554"}
{"id":"4676feab-0d2b-4463-b1eb-8806bb0028fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KJL283326C","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:160e5daf-9956-4dd9-9766-ebc4746d3cb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1646","original_object":"UniProtKB:P41145"}
{"id":"f0bde605-f0df-41b6-9ca5-a584dd18346b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8430","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:06ef7aa0-bc2a-4bbc-a607-f72236791ad0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4291","original_object":"UniProtKB:Q92736"}
{"id":"4743aa30-7caf-4167-ad98-d361123d7d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17364","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:aa38c78e-f09e-4512-b993-39a51b88a853","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6511","original_object":"UniProtKB:O15399"}
{"id":"1d5487b0-e7be-4374-98d5-4b3affa1866b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132937","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:be7af337-cca4-48df-b718-022c4e805e57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1253","original_object":"UniProtKB:Q9QYN8"}
{"id":"65176c3f-f2b3-448c-84f9-56474998cfdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:3762","sources":[{"id":"urn:uuid:f6423003-ac86-46bb-8ad1-9048e7a14581","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2340","original_object":"UniProtKB:P48544"}
{"id":"d37cd449-ecc9-453a-ab03-26f67091d6ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78544","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:a00ba37a-680e-4dd9-bc43-6daad2612e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5976","original_object":"UniProtKB:P12931"}
{"id":"e5e595cb-1239-426f-bde6-d267fea00480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:225865","sources":[{"id":"urn:uuid:25ecc1a4-b159-4b23-9cf0-c59786d87c91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q91ZR5"}
{"id":"80e8e628-1eda-4ac1-a10d-8f7cfbde0f47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9870523","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:17f154c6-538b-45a6-903c-d31baebda4bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1362","original_object":"UniProtKB:P48039"}
{"id":"9d70987c-fde5-4397-aca6-1a4df65e8024","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:d7e1f7a5-6f55-4a91-9b1b-f647937326ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P08912"}
{"id":"165f9153-dfe2-4378-b898-e564e57594ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:fc2c5f21-9567-426c-ae23-4b5b0cf77d79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P28335"}
{"id":"4a6f9199-c6ba-4eae-b0e9-00cb11dab044","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Z28M5SX0X","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:cc1ea91a-0b89-4223-8274-7e1b13e207e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10627","original_object":"UniProtKB:O00329"}
{"id":"8cdf75fc-3846-4741-91f8-c4d6e9c45b09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3624","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:c822d953-0653-476d-a7f4-0d9289ea6214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3624","original_object":"UniProtKB:P49190"}
{"id":"b8c80cdb-7476-4b79-83ea-415f20501daf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:928","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:2d9d48e5-904b-4bf1-ac4d-eeab32f0a73b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:928","original_object":"UniProtKB:Q13324"}
{"id":"d26f4754-252f-45a1-9e76-d106911ed85c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NA1U919MRO","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:8f9635cd-9371-4d35-a689-436aa8cfbbc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9044","original_object":"UniProtKB:P33534"}
{"id":"afafd6ff-b738-44bb-88ea-eac543b6e575","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W51K389XIL","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:42056969-9eb8-448d-9fee-0e2c147efc05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9625","original_object":"UniProtKB:P55055"}
{"id":"6a1bd199-8a54-498f-a70a-b92d4ed6d94b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:5a3ce8bd-e005-44c1-b82f-e1e23c410340","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9BX84"}
{"id":"0032af70-194f-4c7b-9006-8edf8068e528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:174ca4ee-87e1-4331-989c-c25d2f02ac4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:P29597"}
{"id":"377292bc-f062-41a5-8bf0-61655c1193eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:6928023c-495c-4a84-8ee4-6ae18dcd69d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:P36894"}
{"id":"009c79da-e484-4d30-a0c4-869a562c5fb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90851","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:afb0190f-279e-4969-9489-d4985105c197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7626","original_object":"UniProtKB:Q02750"}
{"id":"1b46b8c6-afa1-4e66-a4ac-c664867a6aff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6706","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:104a4526-03da-4813-9827-015e0b713840","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3990","original_object":"UniProtKB:P36544"}
{"id":"4e5e9095-a64f-46a7-8b4f-462e402d0155","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10125","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:1fa900a8-5f9d-4eb4-8826-fdfad7aacb55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4348","original_object":"UniProtKB:P47869"}
{"id":"e9bb7fda-6fe9-40f8-b3b4-eeac0dcbfba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155385439","predicate":"biolink:affects","object":"NCBIGene:3795","sources":[{"id":"urn:uuid:7d999313-662b-4a37-aa8f-36978eab7304","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13033","original_object":"UniProtKB:P50053"}
{"id":"627511fa-8eb4-4e5c-9666-8b61f5fccded","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VO9KX45QIQ","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:f5962046-0479-43b8-82d8-6f5ccacb7e79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11674","original_object":"UniProtKB:P28482"}
{"id":"39d68a92-44b6-4304-bc46-ddca3f749f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56680468","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:34bfede9-19ad-453e-8352-72fcde121183","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8850","original_object":"UniProtKB:P18031"}
{"id":"9df82671-38a4-43f7-8c20-8fbd820fae8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44353447","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:795bf31e-1fc4-48cd-9f6c-37c440fd1b6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:785","original_object":"UniProtKB:P41597"}
{"id":"a3b5ad77-e7cb-4428-83c4-0b746654ba8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195559","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:2a610da4-2eee-4393-baac-1b2d9552e531","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7903","original_object":"UniProtKB:P04626"}
{"id":"62d94bd7-c966-48a6-8aca-ac4bb720d8a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:659","sources":[{"id":"urn:uuid:bab64c62-d8e0-4830-be44-954d1532413e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:Q13873"}
{"id":"50e240b6-be57-41a5-b0df-923b24b4f8ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15365","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:0ec85af4-8289-4a3e-9f76-a0a7441d608f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4139","original_object":"UniProtKB:P23219"}
{"id":"a60ca590-3611-41a3-ab3d-9f2e78beb266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448634","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:ae408fb1-ca02-41b3-a932-0b0d3f804169","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13741","original_object":"UniProtKB:P04626"}
{"id":"66736a28-841d-4217-8a29-cbe56ccdab7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:493d2133-3098-497f-84b0-1f3d5512d447","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:Q96LB1"}
{"id":"e15b4994-0805-4135-83ab-05a31dd9d671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081962","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:bdc9b1b8-6fc7-45f4-a3ec-790733e39158","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9881","original_object":"UniProtKB:Q15910"}
{"id":"aa45cd79-3021-4068-8c81-b338273194f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:7764f8fe-fe25-4bba-922b-83fc581902f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:P56524"}
{"id":"629e2bb1-c764-4ce3-a356-286473c40af4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:ae52b433-6ccf-46ed-8c72-2f5978bb665a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:O00329"}
{"id":"ea9216ca-290b-4da7-931d-27288874a339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:0657378c-4f28-492f-82f3-78f352df3839","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q9UHC3"}
{"id":"929953c8-f057-4b81-b55a-1823a4513373","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24769759","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:071942b4-c38a-4604-a191-763acaa6e6cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13479","original_object":"UniProtKB:P0DTD1"}
{"id":"800995db-8f14-43a4-8bf0-f7981e09cd1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:623","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:a33bfbd4-038b-48e5-9a20-836c5ebb6b65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:623","original_object":"UniProtKB:P28336"}
{"id":"12388660-1f54-499e-8c1b-be9a643ad5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311463","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:7e1eebf9-2500-4cc3-9edb-c7e23150436b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1440","original_object":"UniProtKB:Q14831"}
{"id":"da3b230a-c2e1-4534-be4b-ac3cf8d71947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124173751","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:a55944ef-2ccb-4086-a650-f12502289964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12982","original_object":"UniProtKB:P00533"}
{"id":"b54b1911-ce3b-4c2a-bc10-ab337a3eef77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131174","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:8d7afeca-64ec-4581-a33f-d3ca9d973268","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8319","original_object":"UniProtKB:P10415"}
{"id":"d1e924bb-9b7e-4467-8699-25a44547f6e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4911","predicate":"biolink:affects","object":"NCBIGene:7153","sources":[{"id":"urn:uuid:e2c8e022-6980-49e6-a924-7883b582a2cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6815","original_object":"UniProtKB:P11388"}
{"id":"74467058-0251-440b-9b22-134a82795a0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68845","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:23924df8-9ce8-4957-9c33-ec7d6b4d54cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6901","original_object":"UniProtKB:P30556"}
{"id":"7c004287-9fb8-4a98-a097-747b34fbf56f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:85713MT0EH","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:340424fe-008f-4f8d-bf0a-ab9ada2ee5ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1221","original_object":"UniProtKB:P35367"}
{"id":"6367e85c-223f-4e9a-adb9-287c115f8da5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73437646","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:f6c733d0-90b9-406b-bb24-fb1f776c4326","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8707","original_object":"UniProtKB:Q05940"}
{"id":"ff5e1fe7-eeb4-4b24-92fe-f76f59ebc1be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49868","predicate":"biolink:affects","object":"NCBIGene:10769","sources":[{"id":"urn:uuid:92891ce7-ba72-458a-9f1a-950090ced7d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5666","original_object":"UniProtKB:Q9NYY3"}
{"id":"29e0f819-b0f0-4c19-a191-341d31533c9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755047","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:cf6d7427-a4e2-4d4a-8946-bc6696658e1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3380","original_object":"UniProtKB:P35408"}
{"id":"fba58054-d6cd-443c-8cf3-07319b7c1ee9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L08J2O299M","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:b6c9ebcf-dfe7-4ef5-97ee-0731cc8ebd65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7794","original_object":"UniProtKB:O00329"}
{"id":"32df4894-67c0-4cd3-9f5c-ef23ee9e0a66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:085c8b7d-52b4-47f8-b0c4-773f437ab173","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:P58406"}
{"id":"1c8396fb-7e88-458e-92b8-17ff6919a6fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:113995","sources":[{"id":"urn:uuid:dacc3b77-f3de-4a2a-acb3-f017e5fd8186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P51578"}
{"id":"b15a08f0-4ba1-49bf-9691-a0ccf4c7a8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91663466","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:29a9e550-4cf8-498b-bf7c-fdd99b1603d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1543","original_object":"UniProtKB:Q9ERC0"}
{"id":"622a95f7-b071-428e-abe9-2e32097376f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358781","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:f2483a08-2215-46bc-a2ea-ce84656970aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11979","original_object":"UniProtKB:P40763"}
{"id":"6dc108b7-67b8-456b-ac96-5a180f2e653a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13845","sources":[{"id":"urn:uuid:ebbecece-3c9e-452c-9697-195f27686b66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P54754"}
{"id":"3145a9e8-a125-49da-8977-2389b29f3bcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44465558","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:c23c5165-8917-4f1c-bf36-e54e1e32ca85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8196","original_object":"UniProtKB:Q14164"}
{"id":"4e7dc22f-af71-475d-a071-2d7ce1fff6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9398","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:3ba2a72c-0c46-4844-b02d-af944277997a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:488","original_object":"UniProtKB:P25100"}
{"id":"ef516d3e-75e1-4906-9c99-b7247be0665b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5128451","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:04d30400-2f1d-4573-ae83-437f28cb1f2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:646","original_object":"UniProtKB:P30411"}
{"id":"ae2335ef-7eb6-403f-a396-e27ab535e014","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M18T0TD14","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:b0ed7f06-24da-45da-ab25-c6f1da540f9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1620","original_object":"UniProtKB:P33534"}
{"id":"acb036c0-b8fc-43ba-b3c2-eb20e06a7a1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28241","predicate":"biolink:affects","object":"NCBIGene:5140","sources":[{"id":"urn:uuid:208a1000-51fc-49fa-8706-fd8bee80a8bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13147","original_object":"UniProtKB:Q13370"}
{"id":"d9343adf-78aa-4b74-94a5-53fbc72285a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2540","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:3fa5b749-d1b7-4987-8062-d804c80da336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2540","original_object":"UniProtKB:P54282"}
{"id":"c00ce92f-4362-4f32-8398-adab9d8513cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44316620","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:457ae5bf-ea2a-4997-9892-eb145f61164f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:656","original_object":"UniProtKB:P30411"}
{"id":"86c67dac-4e33-4cb6-8132-40afba7b3b7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SAU68994A6","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:b56a3b3a-7068-4541-8366-c5d127b84267","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8725","original_object":"UniProtKB:P49798"}
{"id":"7d85a933-d568-40a3-b675-07fb7e6a531c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:20273","sources":[{"id":"urn:uuid:43ea9098-53de-4c9b-aa3a-93dce0d229c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:Q9WTU3"}
{"id":"914ad308-499f-467a-87d1-17c5b8622268","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SA2ND7EHY4","predicate":"biolink:affects","object":"NCBIGene:1445","sources":[{"id":"urn:uuid:4c0789fd-abaf-4cfc-9fce-aee03aeb1e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8836","original_object":"UniProtKB:P41240"}
{"id":"5d337f04-1c26-46bd-a743-c195b952ff85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WV82DEG4YA","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:58d0137a-52f6-4d00-a220-40e9ddc62d18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10279","original_object":"UniProtKB:Q13507"}
{"id":"76658c44-62f5-42ed-9fb1-47a807818d60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311228","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:dc3df6ab-866e-4227-9b16-4391de835867","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1932","original_object":"UniProtKB:Q62053"}
{"id":"73591bc9-e940-4bfc-a4bb-46e611dd64af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:773ecd4e-88af-44ba-bbbd-e699c7b0bdac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P07948"}
{"id":"d2521631-50da-4c6d-8061-2369b7f5f699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81389","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:d182665d-cb17-44cb-8dc9-5ddf656db3b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1248","original_object":"UniProtKB:Q9H3N8"}
{"id":"fdf05e4f-b3b2-4890-a903-61c424428e97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:06ffaf89-fbcc-4467-86b5-08bab64161a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P08913"}
{"id":"f0159ab8-9140-4b6c-b244-d3e95d91657f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2270","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:75cc665e-8fed-4658-a627-66aa09a4e789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2270","original_object":"UniProtKB:P32241"}
{"id":"b98c1067-b8ca-414e-99c4-bed7005bc5b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:609517da-ac23-4bd2-884b-52714a7d029d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:Q9QYN8"}
{"id":"f04d2c07-938a-4ca7-a9eb-d3ae7b256891","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134990","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:6db5c57a-0cae-4674-a96b-ccd5df59015a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:198","original_object":"UniProtKB:P28223"}
{"id":"9e8d8237-7728-4478-868c-0a6b64bee3dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13832","predicate":"biolink:affects","object":"NCBIGene:57104","sources":[{"id":"urn:uuid:5c366bfe-c2fa-4db8-acbf-ce4afe9c5143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13832","original_object":"UniProtKB:Q96AD5"}
{"id":"5a049fe1-8995-4328-857e-8e6ad0fed31e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:5e06799f-bb5d-4c90-9017-3e1e1e6819b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4360","original_object":"UniProtKB:P47869"}
{"id":"bb961daf-7031-4770-ae1a-fd2a8076aa97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92566","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:f94c4e92-53e5-499f-82dc-083097f60d1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:122","original_object":"UniProtKB:P34969"}
{"id":"6c1ec736-9466-4403-a1bc-b3007730d72f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310998","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:05f47eff-fd7c-4778-a65e-49d936ade1d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1928","original_object":"UniProtKB:P43116"}
{"id":"b7355809-bf7d-408f-aaa0-91e0b451c5b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64080","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:e47659a3-59b6-4aa4-be57-cea362b401cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9637","original_object":"UniProtKB:P21728"}
{"id":"24c7f906-61fc-4b89-914a-271d07882f41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YUN2306954","predicate":"biolink:affects","object":"NCBIGene:1969","sources":[{"id":"urn:uuid:d784ac74-6e59-436b-b786-9c39dc7d881f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10644","original_object":"UniProtKB:P29317"}
{"id":"fd72b357-0340-45f6-9985-c3e3c82e5dd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11168182","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:973e80d9-45dd-45cb-bd09-56f9d170c83a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:264","original_object":"UniProtKB:P47898"}
{"id":"81fd1103-5c2b-4ca3-a3f6-4b3c76087056","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146192952","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:334b9689-94be-4368-87bb-f4028e355802","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11938","original_object":"UniProtKB:P21728"}
{"id":"a318bc44-330a-499f-ace8-519056cf6286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A07663A39I","predicate":"biolink:affects","object":"NCBIGene:6095","sources":[{"id":"urn:uuid:2168cb52-c8cd-48a7-8a97-8d80c546acfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2755","original_object":"UniProtKB:P35398"}
{"id":"0e778ea4-44c4-4ca4-af2e-092051ab0b9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177536","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:5c9897f3-5ef8-4b72-9867-d58567fc8302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8638","original_object":"UniProtKB:P05093"}
{"id":"9626da89-c325-4b6e-9cc9-18f28ea998f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8435","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:bb2373e3-71fc-42ca-af67-d79268145f22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7279","original_object":"UniProtKB:P21917"}
{"id":"227dd171-1c7e-4419-b990-cc580710fc8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135418373","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:75f71946-2838-431b-8737-b17d510d2ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4052","original_object":"UniProtKB:Q92731"}
{"id":"73437960-885e-4332-9b7d-64242827faa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8772","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:32793f0e-05e4-4812-8f6d-00cbcb589742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2820","original_object":"UniProtKB:Q99527"}
{"id":"564e514f-fc5c-49af-9ffe-8f2e74e28faa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132774","predicate":"biolink:affects","object":"NCBIGene:112398","sources":[{"id":"urn:uuid:7bb596f6-e696-48fd-a51c-587a9a812b83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8454","original_object":"UniProtKB:Q96KS0"}
{"id":"85f9e3ca-2f5a-46ba-9616-d090218d36b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1512","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:2ba3c6a6-b970-41e8-8de3-6fe8e53d14e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1512","original_object":"UniProtKB:P50391"}
{"id":"e645e4a9-e8e2-4f6a-9a61-5d3ed23778dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8356","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:088c39e2-178d-468e-9ef7-7a911867daaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:953","original_object":"UniProtKB:P35462"}
{"id":"a9a03e95-ae9b-4b45-b3b6-4ab2dc317064","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92648","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:ea974889-3b3b-4dcb-a873-8b3614391354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6680","original_object":"UniProtKB:Q99720"}
{"id":"6bf489d2-1f1e-4154-ad31-e0cedcd89708","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q6C8TY6SW1","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:d48a5089-90cc-409a-bfef-beb91ecbaa1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1770","original_object":"UniProtKB:Q9H244"}
{"id":"b84f930e-9c7b-4f7c-a67f-dd322fd55892","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996521","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:59bdde5c-b383-49f8-90d6-f9de449d2428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10582","original_object":"UniProtKB:Q9NS75"}
{"id":"79a9a1ab-5bc6-43fc-9301-f5368479b639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604042","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:7a842e7a-ba0d-475b-879b-06542c252b17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:168","original_object":"UniProtKB:P28335"}
{"id":"eb94ddd8-5a90-477b-a9f8-31d7efd317ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94646","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:1e13bcdb-1f88-47c0-8a95-a91713b38b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2598","original_object":"UniProtKB:O43526"}
{"id":"4a7460ce-e235-49f8-b9f1-efb0e770593a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9R2G075611","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:57d6c638-e113-4d6f-8d35-2f51f46ec125","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8060","original_object":"UniProtKB:Q96GD4"}
{"id":"788eaf76-ffa6-4b40-b5e8-1d55b6412cb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10461270","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:9285db65-8d38-4f3b-b274-989623a587e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2201","original_object":"UniProtKB:P37288"}
{"id":"5bc86935-00b8-4ba1-918e-9abeccacebd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135686","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:6b348eca-e0db-4645-927e-914153eb153f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7471","original_object":"UniProtKB:P41145"}
{"id":"fb052f4d-ed77-4b61-9199-355f187d8c8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71654771","predicate":"biolink:affects","object":"NCBIGene:23411","sources":[{"id":"urn:uuid:ac9c418c-2e57-46ae-a33e-49064e59bfb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8778","original_object":"UniProtKB:Q96EB6"}
{"id":"5cbe61a5-a607-4bbd-bd6b-c9dc7d1cfcb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11193842","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:3eeb695a-94fb-437f-b471-20005cbc61ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7722","original_object":"UniProtKB:Q99572"}
{"id":"aacf88bb-6fd7-48d6-b93c-90964e98baa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36206","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:c7e0662b-25c1-45e4-8882-779dd1ccb061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5850","original_object":"UniProtKB:Q9NQS5"}
{"id":"1c89f7a9-1682-4bed-a2c3-14b244795077","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:17fc226a-4187-425a-876a-d1a4d49507dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:P43166"}
{"id":"c184c1bb-5554-4291-af32-541c80482c95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165413021","predicate":"biolink:affects","object":"NCBIGene:10721","sources":[{"id":"urn:uuid:af92853d-8872-4a43-9662-40488f09e5cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12656","original_object":"UniProtKB:O75417"}
{"id":"0cbc93ab-a985-4848-9e45-b7250ac52265","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57339564","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:42c5eaea-9d9d-4f04-81df-a4f2591c3d66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1516","original_object":"UniProtKB:Q63634"}
{"id":"62868819-b9be-4034-b95e-f35b337981c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:726455","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:779a11dd-d48f-4de5-a8ee-264dad13a0a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9632","original_object":"UniProtKB:Q9BXA5"}
{"id":"dfcd2490-0bc8-44e4-9f66-cea9e1a622b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40629","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:29b75579-2611-4fe8-9e66-a76cd7228ab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7643","original_object":"UniProtKB:P35968"}
{"id":"3cc9e880-f6d7-4b24-9c5c-4b6baf99f5af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:624","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:7177a32a-8b1f-4ab9-961a-0bed2255f39e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:624","original_object":"UniProtKB:P21729"}
{"id":"26b9ec12-c839-4bae-91db-9a0ebc333c71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6709","predicate":"biolink:affects","object":"NCBIGene:9970","sources":[{"id":"urn:uuid:a040ee68-fe54-4dce-a548-faf770af8106","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2757","original_object":"UniProtKB:Q14994"}
{"id":"ceb76e60-a504-47f7-9d28-683e94aecad2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49779607","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:7874ff07-b198-4c47-8753-ad73cf257f1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8705","original_object":"UniProtKB:P21554"}
{"id":"66f1062b-d6e9-464b-94f1-6c01bbce54bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1319582","predicate":"biolink:affects","object":"NCBIGene:3766","sources":[{"id":"urn:uuid:aad1788d-8dca-4e7c-9175-696d99e62302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11821","original_object":"UniProtKB:P78508"}
{"id":"4406e78a-bb17-4dbb-92d6-8633cffd1e01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OYK17DYO9M","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:be606e5f-40c8-47bd-83bb-34099bf681d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10510","original_object":"UniProtKB:P13612"}
{"id":"674204a2-2963-4c2c-ab45-67af4dd619ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63115","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:810fd0d2-d3e2-4103-9e15-2ce7ee88bf72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2407","original_object":"UniProtKB:P48545"}
{"id":"caff1f6e-e2d5-4d18-9a61-e6588c11fc46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2040","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:c133bcc6-f394-45c7-99be-23a187068493","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2040","original_object":"UniProtKB:P30874"}
{"id":"7c01e62b-9392-408d-9f34-6635b585c7bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134735","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:8b793355-8134-47a8-81bc-a159bbaae3aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8402","original_object":"UniProtKB:P27487"}
{"id":"6b613934-b80d-49c2-bee7-e7ad3b53316b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132853","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:52443776-1d53-43fc-a016-a48db11fccc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12550","original_object":"UniProtKB:Q8NET8"}
{"id":"abfdace2-99ef-41bd-bec0-742e37994e8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24873485","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:020b861c-f9a9-4ca5-81ff-805aed6c4649","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8895","original_object":"UniProtKB:P30542"}
{"id":"c1fb5e4a-d949-4c1e-ac3d-8eb8289331f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:a9d7fd1e-5c7d-4132-9315-51909f755681","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:P30935"}
{"id":"0c1a0a18-cc01-468d-9e02-150fbcbf5071","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44321610","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:d4fe3d0c-7ee4-430c-a78b-a1243db728f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13835","original_object":"UniProtKB:P12821"}
{"id":"2da5e5ce-7a09-45c3-80db-abccf1315396","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90645598","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:d7b4e9e9-b636-4beb-84eb-cfdfd1e9d80b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13155","original_object":"UniProtKB:P25100"}
{"id":"ff790edc-82fe-4f65-b682-79cb1df45c51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45713","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:56fb4085-74f5-4779-8dda-08a8aa976733","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8741","original_object":"UniProtKB:P37231"}
{"id":"edfd7a2f-59ad-4218-a1f7-0678e9146525","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76283388","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:dba46c35-660c-4192-8442-22e7d38094ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13442","original_object":"UniProtKB:P25100"}
{"id":"f249be78-7118-45a9-a565-8079bb46c6e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10245039","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:5a517fbd-a8b6-41ef-b505-993713e59edc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1196","original_object":"UniProtKB:P35367"}
{"id":"525470af-f5d1-46f7-8472-e3f907357862","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6931","predicate":"biolink:affects","object":"UniProtKB:P15823","sources":[{"id":"urn:uuid:0e033b1e-cc87-448a-a0aa-24252d37508e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3342","original_object":"UniProtKB:P15823"}
{"id":"56ca84c9-a48a-48c1-9954-4851e874acc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7577","predicate":"biolink:affects","object":"NCBIGene:12288","sources":[{"id":"urn:uuid:f4482c05-258b-4c89-aacd-adb4c667af94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2524","original_object":"UniProtKB:Q01815"}
{"id":"47c1f15e-5456-48c6-b26f-0cb6dc62a360","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145704683","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:a8d4071b-103b-41a8-b1f0-42f3f1c22181","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10580","original_object":"UniProtKB:Q9NS75"}
{"id":"b47bb1b7-4260-4ba9-8f9c-29e9b90bee6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:386fd9d5-222c-405a-a47c-84f707cfc6ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P06241"}
{"id":"d1e5b240-f701-4b6e-af7f-9c07cd15c8ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90471461","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:1a4592d9-32ee-4980-b11e-5dd038c36e48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12472","original_object":"UniProtKB:P59540"}
{"id":"f96ec62b-f3d0-42c8-8e71-e69382cbb7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4312","predicate":"biolink:affects","object":"NCBIGene:80853","sources":[{"id":"urn:uuid:ab71fc79-b045-4ae8-a666-4a60c5e86183","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7025","original_object":"UniProtKB:Q6ZMT4"}
{"id":"79e8eb06-a520-4f8e-af74-3a2a46941b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6498","predicate":"biolink:affects","object":"NCBIGene:2854","sources":[{"id":"urn:uuid:a1879b81-c717-4ec6-9877-8b7de73f703d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1034","original_object":"UniProtKB:O75388"}
{"id":"2376a1aa-564b-46a8-be06-6a25a82cf37d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1JSN1I7582","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:5ef016d7-3ef0-4e6e-931c-1b4443ff8dc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8314","original_object":"UniProtKB:P43119"}
{"id":"50aa1807-f34a-4fc3-93cb-a05b3e7c479a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:cda565a8-f865-45c9-8bd2-57a556ac6e23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P35462"}
{"id":"4bac8609-cbd7-4c82-b092-9d8707c28caf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755236","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:1a165736-6a1d-4cdc-8c54-e2cb8dd54d56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6728","original_object":"UniProtKB:P17764"}
{"id":"4588a821-63ae-4de9-ab14-0487993aff4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46192505","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:69457424-c334-4781-9ec6-01b89a093362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8117","original_object":"UniProtKB:P53667"}
{"id":"62aaca33-20da-463c-b287-8ef28f16aefc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:8364dd61-6f3f-42ff-86b0-e54f2125968d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P28335"}
{"id":"78df8d6f-0197-4689-9071-c3619382bed5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177401","predicate":"biolink:affects","object":"NCBIGene:230777","sources":[{"id":"urn:uuid:d8e0204c-b534-49f4-a6c5-95f0426c07b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2886","original_object":"UniProtKB:P58307"}
{"id":"6df32fe7-5380-4bb2-add4-895a8a241f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115219","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:f9a9eab3-9765-4f36-b030-607cbdce627f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3414","original_object":"UniProtKB:Q9Y271"}
{"id":"cbd46606-565d-4d90-8388-4dffa97fa089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:05a850f9-43f7-47a2-910b-3e7949dc7f38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P18825"}
{"id":"877762ed-e8c3-4556-86a9-5dc4edcdfdb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10158373","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:02858bef-4c83-4e43-8051-9f4a27b1e421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9475","original_object":"UniProtKB:P41180"}
{"id":"d6b7093e-3150-4d9a-abdf-8d373e271d90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5353264","predicate":"biolink:affects","object":"NCBIGene:26946","sources":[{"id":"urn:uuid:89a16f23-7d5f-4b6d-a409-dc50605c7f6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2436","original_object":"UniProtKB:Q9WVC5"}
{"id":"5915b7a5-6e2c-468f-beac-821d856b5b72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6650","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:9b37326a-f42a-4b1a-8090-01bf1287ee1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2480","original_object":"UniProtKB:Q9P0L9"}
{"id":"4c82f914-dd7c-4d3e-8b0b-1df6269f4570","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188970","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:d3680078-bbf8-42d1-a2da-35bf6e9a02aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12559","original_object":"UniProtKB:Q9NQA5"}
{"id":"32747f7f-6b78-4d4c-92fa-065a3829f74d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94489","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:33876735-089a-4f26-b5f9-29f1f002402b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6059","original_object":"UniProtKB:Q15759"}
{"id":"bf930539-9fc6-4c10-96b3-e8fcf631789b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47499","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:f0c57f66-e3d3-435f-bc38-72d4ca16e1a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:357","original_object":"UniProtKB:P48542"}
{"id":"d7a8334f-5706-4477-a41d-672ca0b3c651","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3908","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:5b69a8de-2430-40ea-87ef-5d772d4c83f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12437","original_object":"UniProtKB:Q9NYV8"}
{"id":"b5a03ebc-7e34-43d7-8966-ef925b28b173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76850157","predicate":"biolink:affects","object":"NCBIGene:3745","sources":[{"id":"urn:uuid:faf9aec9-253d-447e-a418-8b941a227b52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11478","original_object":"UniProtKB:Q14721"}
{"id":"e7e29943-89b6-4a0a-ad81-3e1cf4266bf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:b6d1ed3f-6e53-4191-a144-41d47f3c7f47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P25100"}
{"id":"b5626867-5d46-4dba-83d0-f22a54ff1d5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:1744fda1-8abd-461e-bec9-81436d856fe0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:O15379"}
{"id":"5174d4f1-68b2-4397-ac2d-c5b2cbf7c410","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155296190","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:9ed5aa4a-ab1e-4d39-9929-485ae94e01db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13492","original_object":"UniProtKB:P35968"}
{"id":"dd98df20-dbf6-4fd4-a5b6-a67a72424e7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42977","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:8278295c-1096-48bb-825c-cc96bbea89d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2885","original_object":"UniProtKB:P32249"}
{"id":"e26cbe53-8a34-4f62-8adb-ea0be23bd0b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:704bf0ef-1702-4462-98b1-59fa5075dbde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:P56524"}
{"id":"bc91b62b-98ec-455a-b433-54b684141605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YKQ241VJ92","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:b5f3adcc-9f73-4b58-b0e0-354d29eaceed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5689","original_object":"UniProtKB:P04629"}
{"id":"e661d173-372a-466c-a4e4-063f8e0fd873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8378","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:60ce4885-062f-46e9-a536-b6dbf6252332","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2866","original_object":"UniProtKB:P04150"}
{"id":"624a7d98-c41b-49c3-85c5-160566e999c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92300","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:95e0c74d-a232-4313-a10a-ed31d5c51977","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5982","original_object":"UniProtKB:P09619"}
{"id":"594fb579-7e59-4a52-a4a1-aa1b526ab100","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13058","predicate":"biolink:affects","object":"NCBIGene:9099","sources":[{"id":"urn:uuid:30313ded-b357-4fcb-9fa2-60116f6be66d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13058","original_object":"UniProtKB:O75604"}
{"id":"5c41c42b-24ab-44d4-a450-ba169ccb7fd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163359801","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:ab3faf0e-97c5-48d0-b134-820bfeb67ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12047","original_object":"UniProtKB:O60674"}
{"id":"d13ccebb-1ed4-4bae-9d70-2acaef28c619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:e6a9a573-cd86-41f9-9206-49998155ac58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:Q13258"}
{"id":"f1b0d7b5-fb47-4ff6-abfb-d41a5f0fc196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S4N4U44G8","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:8a9f4397-9678-4c57-bd67-8abd3d4d168a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6215","original_object":"UniProtKB:P23385"}
{"id":"807dbac5-355b-436e-8b59-eb7ba4544232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:26831568-7cbb-4c4d-82b4-0c26a07f1d81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:O60674"}
{"id":"a51b4c7d-a389-4d5c-a048-f597f89c6e89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10101670","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:5fca289e-555a-4dd0-8c38-7fe3fa4e233f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7635","original_object":"UniProtKB:P08172"}
{"id":"fc0693f9-aaad-4385-9bb4-a54941bf193b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94802","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:39cea916-a9e6-4084-b0fe-efd01d20e785","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2172","original_object":"UniProtKB:P37288"}
{"id":"b0b7c7d8-edfb-45ba-a0d4-2b17a8d318d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CZ3T9T146K","predicate":"biolink:affects","object":"NCBIGene:24808","sources":[{"id":"urn:uuid:8a9540db-7ce1-49ea-809b-1e189edf6c17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2132","original_object":"UniProtKB:P16177"}
{"id":"d135ed6b-df97-4ddc-94c6-1f51d5c41f06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5972666","predicate":"biolink:affects","object":"NCBIGene:171087","sources":[{"id":"urn:uuid:4af224aa-a484-4081-8af0-2d6117252ae5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11301","original_object":"UniProtKB:P63031"}
{"id":"3e381ec9-1eec-4a51-9b26-87e61bfbf125","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:5e834a27-6e19-4fa1-adaa-575a49b280bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:P22607"}
{"id":"96e81910-f98d-4f93-ac36-c7e71699e301","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:9c2fc413-0a89-48f6-9a97-adf5b6bdf9dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:P31388"}
{"id":"a54b7d73-7f1b-49a6-9185-54106dcd33f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1759677","predicate":"biolink:affects","object":"NCBIGene:115004","sources":[{"id":"urn:uuid:42516275-33fb-4217-a06d-4d63913c2b34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13077","original_object":"UniProtKB:Q8N884"}
{"id":"83f44e78-0a54-4f96-bbff-82bd8886ab10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46894021","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:fe87f175-34d9-4a2d-aafe-bf5e362cb3af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8706","original_object":"UniProtKB:P21554"}
{"id":"1421495b-578b-4983-abdc-539c88f52deb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:77476649-26fe-4385-8be7-221c682bd61c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:P11362"}
{"id":"c05d5970-ea60-4f6d-996d-1fe0477da8d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSZ0E9DGOJ","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:4edd959f-ad72-4765-941b-a78ca16429fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4146","original_object":"UniProtKB:P48169"}
{"id":"415668b5-a41d-40b5-be6c-a784c401beaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7542","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:1669f371-7e05-4bc8-bfed-a90b05006dfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1579","original_object":"UniProtKB:O95665"}
{"id":"ac8d6bc9-4761-4d70-ac58-5475913b1036","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71487030","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:e8dec08f-b521-4256-8065-8136dd41e64c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13783","original_object":"UniProtKB:P21453"}
{"id":"d208167c-cc6d-4735-9b68-ab954f8c92df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1816","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:665d3834-65da-4f33-ace8-66ef6b400233","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1816","original_object":"UniProtKB:Q03431"}
{"id":"bcc92a42-fac2-4f28-abcf-1949037211dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131196","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:8cce4fec-073f-4175-a8f2-1ca5fc2600cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8005","original_object":"UniProtKB:O15530"}
{"id":"9f8393c4-3289-4994-98c1-692474176201","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71041983","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:eb749eb0-199d-4ee7-9207-9f7910e2c580","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6706","original_object":"UniProtKB:O15303"}
{"id":"5470227d-9f87-451a-a2b3-5c64d65b1f13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:0fc80d93-97f6-4252-b30a-733978de0614","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P28222"}
{"id":"69f8862f-f1e7-4916-8151-e2b71fc38cf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4293970","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:fb9db5ae-ae8e-4d72-aa4a-d63b73e93e44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10151","original_object":"UniProtKB:P48736"}
{"id":"ea38f40e-226c-46cb-882a-24896e85da2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54587590","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:dcee03a7-6902-481c-932b-ef89ba2ae01e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5755","original_object":"UniProtKB:Q8TDV5"}
{"id":"ba93d3ce-c3cd-4826-9973-b6acfbb33eaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BTS1Y6777M","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:64c3a1ed-f2aa-4f4a-8c2f-f113d811de55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3290","original_object":"UniProtKB:P30542"}
{"id":"8934f7ca-ca0d-4942-b8e3-42fa3e7d524e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:049ceb9f-ce17-4813-90a8-d8c8acdfe114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q9UQL6"}
{"id":"0d82d7a1-d30c-4063-87df-869928737015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232390","predicate":"biolink:affects","object":"NCBIGene:6344","sources":[{"id":"urn:uuid:0ccb6fd2-4fc9-40a4-858f-1fbeae50849e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3643","original_object":"UniProtKB:P47872"}
{"id":"66511577-38c0-4bb1-bba4-8f32bb3e06a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3T5XXY9HX","predicate":"biolink:affects","object":"NCBIGene:4170","sources":[{"id":"urn:uuid:7b300d5d-ee67-4eb8-b556-ffc0745a0e24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11783","original_object":"UniProtKB:Q07820"}
{"id":"c7da3f30-29d5-44c5-8521-965c5b1ee345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:18166","sources":[{"id":"urn:uuid:cf61259f-f86f-4172-95d2-163ac507db88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1521","original_object":"UniProtKB:Q04573"}
{"id":"8ea14855-7541-403a-aa20-fab17a550685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46245518","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:517330f9-5e2f-4023-aba2-8e3d05c62ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9191","original_object":"UniProtKB:P41145"}
{"id":"868e9cb2-e42c-456b-877e-285293a0535a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173077","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:ed86f205-9f1b-4319-82e4-c3ee3d371212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7875","original_object":"UniProtKB:O00329"}
{"id":"7db062d4-7a76-44f0-9129-a43ae5c98713","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6BTT8VA5Z","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:36d481e7-5ee3-4ea0-9e91-2878d88e7b37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4460","original_object":"UniProtKB:O43614"}
{"id":"38076a13-7184-4633-80d2-8fd19f084522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118612873","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:1d55052b-02ae-41f8-98ab-3911e0fde775","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11876","original_object":"UniProtKB:P42336"}
{"id":"7430b3a1-e406-443b-bcae-59cd787601ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688563","predicate":"biolink:affects","object":"NCBIGene:7016","sources":[{"id":"urn:uuid:0a55e76d-cf51-434f-9ee4-f1c09b0b19d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8119","original_object":"UniProtKB:Q15569"}
{"id":"464cd913-b219-498b-b533-0f4c5a3fc630","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38H2BE6LU4","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:258dec84-3ddf-4bdf-a161-1facd43604d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12956","original_object":"UniProtKB:P35372"}
{"id":"26565e63-04dc-4d64-ad44-5690a261ef81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:159a57df-28c3-441c-a29c-3670b4649969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4231","original_object":"UniProtKB:Q13002"}
{"id":"2a563f76-e97b-4c40-9ca5-5b7bca635c27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188525","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:383afef5-1f50-4c63-9979-d85fbab89004","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:46","original_object":"UniProtKB:P08908"}
{"id":"22f999dd-1dcd-4097-a14d-ee6de3288e17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:70ac9a86-06cb-44f2-8659-9a6e00629714","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:P78348"}
{"id":"a5abfff3-e59e-4e64-985e-c74e69f0722a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50122","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:7a0cd127-c31e-4b99-a41b-986b8724f752","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1056","original_object":"UniProtKB:O14842"}
{"id":"362aaf5a-c77b-47bc-91cc-1896a4bb6be5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57523087","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:6474bccb-042f-4478-a6a1-e89e01e53722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7754","original_object":"UniProtKB:Q99705"}
{"id":"efe6763d-cfb7-40b8-b111-f1fda00d0c29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50122","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:fb32eead-afc3-4466-864c-302fe9011ea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1056","original_object":"UniProtKB:Q9UL62"}
{"id":"e4baca2a-f726-42b3-90f2-6e340849809b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233320","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:26aa329a-0ab8-493d-bfa9-ce5574965dfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13459","original_object":"UniProtKB:O95136"}
{"id":"e387eb5a-6445-4a32-ab22-1dccac9ceeda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54669783","predicate":"biolink:affects","object":"NCBIGene:23569","sources":[{"id":"urn:uuid:eb8c8027-23c8-4b5c-93b2-92e938c7fdec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8625","original_object":"UniProtKB:Q9UM07"}
{"id":"8ccd6de2-3505-42c3-97f2-58658c709178","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311400","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:fcd45724-dc48-44a7-a0f2-501032906d79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:900","original_object":"UniProtKB:P30553"}
{"id":"e245dd75-d0ed-4e1d-8073-121c35f7e007","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35420","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:5d13c6b0-7727-417a-9e4c-e8403e1b99aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4290","original_object":"UniProtKB:P23415"}
{"id":"60953ff3-e597-4117-9956-68d5872653ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N03P021J8","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:b6d87c31-0a63-4059-bd3b-dab6d0eb820b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7954","original_object":"UniProtKB:P23458"}
{"id":"1f6ad112-c4d4-42f1-b625-ecec7bba99e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:fbf2ab56-7272-4c26-b8d4-ae228ddf8be4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P28222"}
{"id":"64acc03b-edd2-41f7-9c98-12c95304a5fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:bd60ebf3-4a2d-4daa-b4e5-1f8ed8128cea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P08172"}
{"id":"8289aec9-58af-449c-a683-930d4980de4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:a31cee79-982c-4473-93f9-9c2e464b4dab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P08912"}
{"id":"4aa2723e-b151-47c2-9628-7311fb0ede5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91455","predicate":"biolink:affects","object":"NCBIGene:5590","sources":[{"id":"urn:uuid:643de08d-097e-45dd-b3f9-d3735aa10f24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5192","original_object":"UniProtKB:Q05513"}
{"id":"af84a565-3900-4ea0-823c-6abbae77c05f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R9Y8EY0G42","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:749c23e5-7523-4003-8e9b-265a4f23516e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9617","original_object":"UniProtKB:Q9Y233"}
{"id":"8ce868b1-9e1c-4b9f-bc87-9fe34402f78b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W6I5QDT7QI","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:57a5819f-13cc-48e9-bd9b-d6a10bbf880c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9322","original_object":"UniProtKB:O75116"}
{"id":"5b4ccd3a-65bd-4bd9-a792-3702a80b7df1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:29713","sources":[{"id":"urn:uuid:14835fbb-388c-4986-8f60-04f8c0dab257","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P48548"}
{"id":"47be6afb-4ddd-4665-8880-4b3e1e5fa14a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:5311","sources":[{"id":"urn:uuid:e2b4cebc-7501-49ed-b36f-fe3eb6429af9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q13563"}
{"id":"015c747f-39eb-4eb3-b60e-15a0a1466a03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:01a9d9e4-54ec-46bc-9d58-585f9bbe3ea2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:P36888"}
{"id":"fa513991-e972-42a4-aa7f-59d6959d4c61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817482","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:6c830203-9af1-4aaa-a569-b0cf17e705be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6093","original_object":"UniProtKB:O43603"}
{"id":"be388081-7486-40d2-afa6-fa50ef81213a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3941","predicate":"biolink:affects","object":"NCBIGene:50839","sources":[{"id":"urn:uuid:c82572ff-4335-4df7-ba86-06fedbbaddb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12432","original_object":"UniProtKB:Q9NYW0"}
{"id":"013c43c8-c288-49ca-82e5-b747a6292b28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16122905","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:9590b8e4-79d2-4839-9bce-5d7281f50e09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6066","original_object":"UniProtKB:Q8NFJ6"}
{"id":"d6eda7d2-b3d1-40a3-abf3-6bd807fda7b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:2ba7484d-93de-4a5c-8d2d-5b67087f296d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:Q9UM73"}
{"id":"e45ad881-f729-47be-a933-f6d4dc4fdc32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:32389f9a-7b3a-478f-a81e-a213c3849ece","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:P05771"}
{"id":"29a82f60-b94c-4224-919d-6558fc8aa5c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:24ff2f97-f014-4bc8-9206-1c71e9f5b774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P32305"}
{"id":"379a8269-405b-4712-be97-761cfc39cd9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9618971","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:fb6850c1-8dba-4f95-8160-cd4206781a6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5835","original_object":"UniProtKB:P21462"}
{"id":"ca9ec84e-c49b-4c39-b8d0-bdf39585cdad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45951","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:f7295951-ae7d-4270-b415-04b7ce16ab35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:214","original_object":"UniProtKB:P28335"}
{"id":"2c0aa680-2b05-4c37-8c88-3860432ede2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N7T15V1FUY","predicate":"biolink:affects","object":"NCBIGene:25635","sources":[{"id":"urn:uuid:49427df5-01dc-49df-b585-1794d2420259","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9272","original_object":"UniProtKB:P70596"}
{"id":"2037b909-ba26-4dba-8f08-38bfed34ca3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MN9LW8268N","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:6cc752d7-fd05-41b0-bdda-c235eab8a295","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:229","original_object":"UniProtKB:P28335"}
{"id":"19fb0eb6-9c9e-4489-897a-285e868fd6a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9549296","predicate":"biolink:affects","object":"NCBIGene:7535","sources":[{"id":"urn:uuid:e4f8b2a4-d75c-437f-8438-6cb0ddf5b8f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6047","original_object":"UniProtKB:P43403"}
{"id":"868579a9-2bfe-4646-8e81-f6850c55fb0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:343450","sources":[{"id":"urn:uuid:cd996ff9-f20b-4674-abe3-727105119b2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:Q6UVM3"}
{"id":"f28bad02-7b07-4d7c-b255-ebd63c98f65d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:4ad4a1c3-fc81-498a-ac74-8f640d4905a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q9Y5S1"}
{"id":"fa015011-2e34-4bab-8ff5-c47f4927eb0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925842","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:a27c0b00-c933-4dd4-9f20-4c1a030bfc8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11520","original_object":"UniProtKB:P0C6U8"}
{"id":"f0f8c29d-69ba-4d44-ad8b-6a31d95c6e45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132268","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:9922777d-6ad1-4039-84e4-9f2bf7dac6ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7422","original_object":"UniProtKB:P04626"}
{"id":"d89ecaf1-222b-4637-a27b-4c0c620e27b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HW3U676A69","predicate":"biolink:affects","object":"NCBIGene:5792","sources":[{"id":"urn:uuid:cc83bf8e-2aca-43af-98bb-71fed8e41379","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8770","original_object":"UniProtKB:P10586"}
{"id":"46fc9fd8-54ea-4d2c-9bd6-49e01acde04d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2207","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:8fee1aa4-c0ed-4730-bb64-465c52b2f399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2207","original_object":"UniProtKB:P37288"}
{"id":"67461578-efac-4faf-a4b7-7919ade0eed0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:96a1f10f-0d47-4847-85e7-4c7e849738d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P20309"}
{"id":"3caa34a2-316e-4292-bcd9-2b299010a56f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228209","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:be9381a3-5d70-4f41-a135-00e4a05cdadc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5928","original_object":"UniProtKB:Q13315"}
{"id":"3220966b-f08a-4d03-98c9-cfc660221f47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2563","sources":[{"id":"urn:uuid:a8e5020a-fe71-4cf0-a7c5-001c3cf80d5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:O14764"}
{"id":"4c138fa6-0cee-4a42-96f3-fe55c10245c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3832","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:99280866-e9c2-4e72-95d8-d90ea0c765bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3832","original_object":"UniProtKB:P33535"}
{"id":"d9c3fbc5-1812-421d-83d5-43f85ccf4728","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46912833","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:b0b19792-0318-430b-a60a-f25068d273ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9338","original_object":"UniProtKB:P21554"}
{"id":"2f455007-ac22-4304-97fb-0459c730ab38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35940","predicate":"biolink:affects","object":"NCBIGene:25570","sources":[{"id":"urn:uuid:5bb3e400-661c-443a-aaeb-82b320b2bfc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2139","original_object":"UniProtKB:Q01717"}
{"id":"6bb05b96-7792-49b3-80fd-f312b8b4218e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2017","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:77c1e42b-0c22-4676-a20f-65023a850b4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2017","original_object":"UniProtKB:P30872"}
{"id":"2ef5ab0f-77f5-4e0a-9baf-8f56e720b26c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:1377fcfa-2007-4179-b816-d46c9ef69aa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:Q92731"}
{"id":"e5d95c46-d63c-404b-bab6-50340705f2f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129188688","predicate":"biolink:affects","object":"NCBIGene:747","sources":[{"id":"urn:uuid:5525a094-cbfa-4b62-bd82-e65dbf2bb7a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10244","original_object":"UniProtKB:Q9Y4D2"}
{"id":"0ffa1431-067b-4314-8912-4f8e8af99ed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93432","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:a7c31ccc-9d72-457d-af07-6af7d08a2727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8584","original_object":"UniProtKB:P08172"}
{"id":"4aa73a1f-b1a1-4be8-b11e-18517614b75c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180905","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4cf0fff1-58ee-4db7-9f0f-73c0babe5fb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2559","original_object":"UniProtKB:P0DMS8"}
{"id":"1a1d3cd9-d72b-4b48-90ef-c7e0a8110011","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2568","sources":[{"id":"urn:uuid:89ff284b-facd-48a3-afdc-4137fa1b59b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:O00591"}
{"id":"8028dbe0-3f1b-4ef3-a438-1077753faad0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10125","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:dea5e469-5ad2-4f14-b613-b2a64d994ef6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4362","original_object":"UniProtKB:P14867"}
{"id":"20ebefa5-11fa-4f84-b26d-dd9742ea2dc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813908","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:4ca15add-b23d-40e1-af51-c72245d00ec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10072","original_object":"UniProtKB:O60885"}
{"id":"641ad4b7-e810-4f1b-90a1-cde751d53f66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94343","predicate":"biolink:affects","object":"NCBIGene:23446","sources":[{"id":"urn:uuid:90325eda-7e3e-4589-9728-17d0bc1da816","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4494","original_object":"UniProtKB:Q8WWI5"}
{"id":"6a5b2eb8-5ffb-411b-8e99-e2905ed14784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135484064","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:3099ee49-1af8-4c94-b36a-44070fef4d30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:390","original_object":"UniProtKB:P29275"}
{"id":"9d14af09-c6ae-456f-9e49-61a20f614bdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135923","predicate":"biolink:affects","object":"NCBIGene:2548","sources":[{"id":"urn:uuid:f8d5063a-961f-4c1a-8487-cc12df90de66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10200","original_object":"UniProtKB:P10253"}
{"id":"a3292188-bed6-4779-9a70-c752174809a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50859","predicate":"biolink:affects","object":"NCBIGene:6257","sources":[{"id":"urn:uuid:93eb238e-03d0-43be-ab2f-d8c5541823d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2807","original_object":"UniProtKB:P28702"}
{"id":"e5a83358-3daa-4bf7-a9d7-9d6c953bb903","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67237","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:cd8f6862-bf3e-41ac-88b5-8e835cc24607","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2742","original_object":"UniProtKB:P55055"}
{"id":"a1799967-eea7-4102-87b9-27c816b55388","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143992","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:e4316c17-b3e9-4795-80db-e204b26570a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1410","original_object":"UniProtKB:P31423"}
{"id":"d32b6054-0c0f-4541-95c2-d3f0a34846d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6075","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:dd75a6af-3660-4d57-b7cd-5c1ca827f178","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6075","original_object":"UniProtKB:O43603"}
{"id":"d5114571-e7ad-4d89-8a12-73149272ed49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9436","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:14ed4e62-2543-4697-98fb-215f40be93be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9436","original_object":"UniProtKB:Q9UKP6"}
{"id":"fbec9d9a-58ee-4b72-9df0-953dd5901f8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2183","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:425e399a-957a-4464-b6b0-17944f49e803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2183","original_object":"UniProtKB:P37288"}
{"id":"66b2c4c1-9aac-456d-bcae-b3713747839d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34952","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:d7ae34fb-3e75-4940-9dc6-f12e5b1f04e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4297","original_object":"UniProtKB:P47869"}
{"id":"a827ae41-9d3e-451c-a6d8-ed3841012aad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S0CE8P9OKW","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:2c72725a-a91f-4994-89d2-98d9b4f91404","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12051","original_object":"UniProtKB:Q12879"}
{"id":"c961fd78-463d-4eab-9fbe-8e5f97813c0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:521c5cca-844d-42d2-823d-4732dac86dfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:P37173"}
{"id":"71f507f5-8cb3-4192-be51-b472324a9da4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2PEX5N7DQ4","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:ec74683a-23b1-4d86-870f-5eb51e5cf9ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8995","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"1128fb6d-2f87-4f30-9526-9d7b4f525690","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44631903","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:da143018-6e90-484c-9217-e0a6af81a619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8045","original_object":"UniProtKB:P49137"}
{"id":"9c906525-b6d5-4670-a3bc-dd4072033c50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10605470","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:723ccf1d-0bbb-4ed6-8ab7-a90d6a06e480","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3519","original_object":"UniProtKB:P25101"}
{"id":"e2567932-9682-44af-bb74-d364d660bda5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312112","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:db688794-2cd6-4029-a2d5-805cca6f5b99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:415","original_object":"UniProtKB:P30542"}
{"id":"3cada5ba-92c3-46d1-808b-a6635b9c3966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:7f93c205-7505-48a1-a2e4-09ae8b34fbc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q15858"}
{"id":"5cb00d27-1190-4e77-a974-44d788951613","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132000066","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:760c8b4d-1a00-4a93-b22e-0e1288bf7ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10127","original_object":"UniProtKB:Q86WV6"}
{"id":"ba0a6a55-7132-419a-ac3b-d66d1f267f4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49847690","predicate":"biolink:affects","object":"NCBIGene:330","sources":[{"id":"urn:uuid:61743e7c-ae9d-4981-bfdf-e2bdf1426e78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7710","original_object":"UniProtKB:Q13489"}
{"id":"cb333f98-1405-426e-ab49-d95869e07640","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817474","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:4b7b5625-3989-4d49-94fb-239e5f69fdeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5357","original_object":"UniProtKB:O43603"}
{"id":"f8191b20-9760-4f8b-9e4d-45df6b587513","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80229","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:38f65e29-2bf9-47d1-a0d8-a3208e7e9d10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:616","original_object":"UniProtKB:P28336"}
{"id":"f48bcb41-9efc-4e40-8abf-b5636572863c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XE10NJQ95M","predicate":"biolink:affects","object":"NCBIGene:31","sources":[{"id":"urn:uuid:ce37244d-762e-474a-85b5-888e57ed039e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10645","original_object":"UniProtKB:Q13085"}
{"id":"8edc063e-a2f0-4f41-a86f-7a50071fbb70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91407","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:4aa4dba4-e8ed-49e1-b2c7-4dce84ba5150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7791","original_object":"UniProtKB:P23458"}
{"id":"4f5a503e-f662-4e26-be6f-0c5c9ff74028","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31296","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:2aa2cae6-7059-47c4-84fc-6c770cc9b94b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7670","original_object":"UniProtKB:P14416"}
{"id":"cee90419-da82-4bd7-9b30-8a4edca509c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17364","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:15348209-6642-40d1-a626-71d2e4b7ffa2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6511","original_object":"UniProtKB:Q14957"}
{"id":"5c2ac09f-72ea-499c-9796-e4304ff0d0d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:50599","sources":[{"id":"urn:uuid:0d88472c-376a-4bff-b9bf-67d1f85cbd2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P63251"}
{"id":"aac87054-33eb-4de3-9058-81884180bdc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:100MIC832U","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:64521b08-06e4-4ad6-a277-9d77a61cd635","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8430","original_object":"UniProtKB:P28223"}
{"id":"f1ff7167-0bcc-480d-bfe0-f45a74520d4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15608077","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:9ffc8c48-37ed-4662-83b6-8fca618d3134","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1217","original_object":"UniProtKB:P35367"}
{"id":"07161bdf-cf55-41b6-99d5-385d701b6acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5327339","predicate":"biolink:affects","object":"NCBIGene:840","sources":[{"id":"urn:uuid:6dd7c97f-e339-4fc3-80a2-2f9c65459edd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8628","original_object":"UniProtKB:P55210"}
{"id":"f425d703-4d61-49a5-94e2-b52d8d9a818e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:ad05d266-a9d4-4baa-9fbd-e88dc3ad0c52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P28566"}
{"id":"b5a3f24a-a5dc-486a-9bb5-1144a95dc1d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:8513ce2a-cc80-4fa0-bb5d-aeefad0c8985","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30875"}
{"id":"aea3b0bc-a85e-4949-bdf1-a336c9c6bc4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22003577","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:6b04dde9-5b54-4819-9116-1bab92766cd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1738","original_object":"UniProtKB:P41231"}
{"id":"056acfe1-2d63-4312-bfcb-33f59f16a6a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755018","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:0e56eac6-2447-448e-a546-4ec517a54f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1844","original_object":"UniProtKB:Q62035"}
{"id":"b3f9eb39-1e87-4571-8b11-70278508ffee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688690","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:08062927-b1b7-473e-bb17-17d85bec8673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8118","original_object":"UniProtKB:P53667"}
{"id":"4ce9e783-6c82-474a-a8bc-abc338f710ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32076","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:4e63a3e6-326e-471e-b326-9ea4859878ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2597","original_object":"UniProtKB:P51787"}
{"id":"2fdb7795-1395-4b79-913d-6b5714757077","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228679","predicate":"biolink:affects","object":"NCBIGene:64781","sources":[{"id":"urn:uuid:44f5a71b-9cf4-46bd-8437-0218bf57fc91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6668","original_object":"UniProtKB:Q8TCT0"}
{"id":"2e440a5c-31de-4c2d-af4b-db10957958ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FMJ6D8Y1B","predicate":"biolink:affects","object":"NCBIGene:25750","sources":[{"id":"urn:uuid:f7911916-9f32-4b10-adcd-14972cbc8891","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9754","original_object":"UniProtKB:P19643"}
{"id":"f8cb1b07-905e-4dce-92fc-fc61f6d10a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9938757","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:ef59aa0d-660f-4e4f-aeda-d9c43b4a3b4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2015","original_object":"UniProtKB:P30872"}
{"id":"209a0157-f54c-4570-922b-f9e19513ddd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9917025","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:c8e7b067-7365-483f-829f-3cd68cc28df1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2204","original_object":"UniProtKB:P37288"}
{"id":"08ea724f-e3b4-4ba8-80c1-dfd9ba3e89f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8691","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:349e25c9-eacc-4378-87b4-51ee7ea588da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8691","original_object":"UniProtKB:P27487"}
{"id":"554290e9-04ee-4253-ae85-be8f09f42a73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92140","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:36ee3c30-d9fc-411d-a3a1-d7a95745e3b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4240","original_object":"UniProtKB:Q12879"}
{"id":"65473140-0e9b-44d0-96a7-117763e2f3c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OJY3SK9H5F","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:da0970e2-68fd-447c-a4d9-705103ae97f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11486","original_object":"UniProtKB:P13612"}
{"id":"3fbd615d-e299-430d-b044-86d312173065","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:173382","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:8101af8a-d8d8-4a6c-b93f-31f995e8eed4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:533","original_object":"UniProtKB:P08588"}
{"id":"c658e5b2-38b4-4c44-a5bd-eeca9465bc04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10046145","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:64d11807-c3c5-493a-85c3-a08ee2b6d9f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5610","original_object":"UniProtKB:P30542"}
{"id":"f59377f9-4c4b-459b-9708-9e929815c3a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:141754136","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:61e1dc9c-238b-45ae-b668-1ab5475495a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11204","original_object":"UniProtKB:O00329"}
{"id":"e186951e-91e3-4f7a-b0e2-e49e3e8565a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11668217","predicate":"biolink:affects","object":"NCBIGene:6732","sources":[{"id":"urn:uuid:6a623352-6399-4811-8245-4dafc6f5e920","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8188","original_object":"UniProtKB:Q96SB4"}
{"id":"19843b7f-e096-42f8-adbf-cbc65b8f3d77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91634","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:64d6eb65-72a5-4af9-bfeb-560314375fb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1613","original_object":"UniProtKB:P35372"}
{"id":"eb7ea728-9202-4d6c-8e02-47ce92a1ad88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4560409","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:f510201e-3fd6-46c8-a923-12b87e1a0c55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10080","original_object":"UniProtKB:P34913"}
{"id":"f61f66a6-f3c3-4eda-bf1c-c456ddb7c8f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46943415","predicate":"biolink:affects","object":"NCBIGene:1457","sources":[{"id":"urn:uuid:0e841872-befa-4507-9447-67a4433d3c26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8140","original_object":"UniProtKB:P68400"}
{"id":"21e9d0d0-f45c-4ba3-b4b1-cdead736bf03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93424","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:43ffca9e-6837-4d73-b040-b785547b5f8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:403","original_object":"UniProtKB:P30542"}
{"id":"a45bc1d8-66d4-418e-a3dd-2e2e0b11abe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92361","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:e1f1712f-36f9-4a3c-a989-0df996b86616","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:405","original_object":"UniProtKB:P29275"}
{"id":"a4562610-4c36-4864-a6b2-d61f111d8e6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47780","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:2819e105-df60-47b5-9116-357460b935fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2398","original_object":"UniProtKB:P31645"}
{"id":"913f0369-328c-4fc2-aaf5-f7a90cde8706","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:3ea70c3a-20ca-4ccb-a89c-fe7cad46ab00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:Q16288"}
{"id":"00c3b049-ebe0-46de-aba7-03b23bdeaf76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9546625","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:7822753e-5a9c-480f-b230-5129f2ad62c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1829","original_object":"UniProtKB:P25105"}
{"id":"04ca37ab-54f6-4515-a2e6-56ae3ab1f7da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147075611","predicate":"biolink:affects","object":"NCBIGene:29710","sources":[{"id":"urn:uuid:88795f01-f526-480e-8400-29f1aa9bab5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12643","original_object":"UniProtKB:O88420"}
{"id":"f88efb0a-333a-46d3-b100-60f425c12545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:27133","sources":[{"id":"urn:uuid:67bbc42a-ec8a-4cfb-987c-55dfdf79b297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q8NCM2"}
{"id":"5ee78b30-d238-4932-9374-ba6cf5beeb57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431314","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:2ad77623-19c3-49e2-bea7-63f898ac1537","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11288","original_object":"UniProtKB:P35462"}
{"id":"e4767a64-ae21-451c-9959-32e641982be9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25020407","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:2012cb3e-2762-4c13-ad1e-07f42795c62b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10381","original_object":"UniProtKB:Q9GZQ4"}
{"id":"90b8d5b3-ab34-41d4-80a2-ee8f0c8779bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813897","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:71de4182-771d-4395-b6ba-bb615e3f230c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8524","original_object":"UniProtKB:P35414"}
{"id":"008298f0-9aaf-4339-aac1-2561c198b50a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:3765","sources":[{"id":"urn:uuid:cf76ff5f-d297-43d4-af42-fdac555f7a98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:Q92806"}
{"id":"1654f732-503f-4ecc-ba00-c34c4124c22f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6741","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:ac815965-ebf3-48a1-9fed-e858ba65058a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7220","original_object":"UniProtKB:P35354"}
{"id":"4476fb32-1af9-4f3d-8442-038dadaec156","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:b9a53f32-99b9-4bcc-8945-2ce310e01f1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:Q9UQD0"}
{"id":"8acd4bec-7e89-4a52-8454-2526d46408f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:cf72e7a3-2546-418a-90e3-26c5cfad2539","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P34969"}
{"id":"9db6f3e7-cd28-431a-8093-d73de1a4f661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137455315","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:5e196147-7b85-4dd9-adc9-106255372089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11869","original_object":"UniProtKB:P12931"}
{"id":"a22ad67a-eaa2-476a-9fbe-e0d66900e04d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L46509378R","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:cdf03084-07ca-4ab6-b91b-481593708b8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12040","original_object":"UniProtKB:P08235"}
{"id":"546a6253-bd73-4123-a6c4-8312a8f93f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11459","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:70090ba1-e88d-48e8-9951-8e670ac306f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11459","original_object":"UniProtKB:Q9NSD7"}
{"id":"ae586b0f-7513-422f-a766-2dab72f09c1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34543","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:72a479ae-88e5-4ee6-9b09-71dd70738e2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2168","original_object":"UniProtKB:P37288"}
{"id":"4df2472b-2f5a-4707-9064-18e42f7b298e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U59UGK3IPC","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:428fd4cc-db71-4a79-b768-9461581329c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8920","original_object":"UniProtKB:P11836"}
{"id":"a9c7c93c-edc4-4bb0-a088-816908107ffb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:14a48b1d-50b8-479b-b8da-e368e80bd3f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:P31421"}
{"id":"61fdd0f7-ac7e-4c66-a620-eef251ba98b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9915499","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:668ded74-6a14-4318-9099-be2db7952c0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1581","original_object":"UniProtKB:P20789"}
{"id":"900a795c-def2-4a33-852e-3eafcb29e2dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BSOIY5AKQW","predicate":"biolink:affects","object":"NCBIGene:252900","sources":[{"id":"urn:uuid:51429c1c-8ac0-4340-8ceb-b4ff86e69559","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12241","original_object":"UniProtKB:Q5FVP8"}
{"id":"a5ec286a-fed9-4162-a067-11b1bebdeb4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3648","predicate":"biolink:affects","object":"NCBIGene:1235","sources":[{"id":"urn:uuid:6cae6cfa-b308-4193-a36d-d5d11f86bf25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3648","original_object":"UniProtKB:P51684"}
{"id":"ad3385ea-d18b-48d2-8539-2def9bedd14f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6610278","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:69675dcc-5e70-4b06-9c9a-cefb9ad1227a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5930","original_object":"UniProtKB:O14965"}
{"id":"7f8147a2-b368-4efe-995c-506e4d567326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:aa451459-7760-4c48-9cb8-618be1c9a4a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P30083"}
{"id":"94fbc22f-78c8-4bf0-bf01-2754d26021fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:103828029","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:8d6d5148-d878-4201-b927-38653ada5d02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10667","original_object":"UniProtKB:P49286"}
{"id":"ed60405c-7ac6-45a3-8315-423aa6280ced","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BCV386QGUZ","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:65714f0d-7697-4f67-a01d-72d5912601aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9731","original_object":"UniProtKB:P08235"}
{"id":"25437901-7067-4833-a6ec-ea1a9e193e11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947050","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:36afd2ab-c64d-46e5-94f5-328aa36c9e0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3123","original_object":"UniProtKB:P37268"}
{"id":"08f35908-68e3-4f85-9326-77cbed490fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:56659","sources":[{"id":"urn:uuid:c306bbe6-9b0d-4bcb-92a3-e278e2e7fa08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:Q9HB14"}
{"id":"b186def3-61ed-460f-813b-696a1aa6cd2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131351","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:3009e639-e640-4db9-8189-234d4b1e1533","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:384","original_object":"UniProtKB:P0DMS8"}
{"id":"259cea26-1b59-4556-9e53-7a22ce38f46f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1124","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:f5a50ce6-2c28-4b1b-a9a4-a3d24c5c7f93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1124","original_object":"UniProtKB:Q02644"}
{"id":"d5aa370d-fbdb-4105-bca8-de5ad1b9e402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NT43S9BKJ2","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:a123f1f9-f03b-4f37-98d5-d76508ff28d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8870","original_object":"UniProtKB:P41143"}
{"id":"4d8511bd-308c-46a6-ad06-5b81c005225a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5472558","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:8eb44198-4e47-4218-b988-28e4b7da1d7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5944","original_object":"UniProtKB:P06493"}
{"id":"c97ff187-e067-47d4-bff3-8700e734a889","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5E7RR1J6TR","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:0deb3e3c-9a43-469d-bc82-fa84e4bb6ca3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10336","original_object":"UniProtKB:O95069"}
{"id":"ab02aebd-ca46-4f75-a896-18a8fbf2a487","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:ef049e0b-39af-4f0d-b797-962512a0806f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P43116"}
{"id":"e0607764-32f3-4dde-ae56-615faffd58f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44430519","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:2f33bbf5-6ef9-4637-a07a-88ca01993a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11252","original_object":"UniProtKB:Q16581"}
{"id":"9ec74c18-53c3-4018-9b2b-5583cad29c52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10251","predicate":"biolink:affects","object":"NCBIGene:310327","sources":[{"id":"urn:uuid:62585074-cea6-41ea-b6ec-a14aafb18389","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10251","original_object":"UniProtKB:P83858"}
{"id":"45fd1cdd-cb44-42c6-a253-a3ae0fdb5824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194387","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:e3ca846f-a366-43fb-9230-851390bcff8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1393","original_object":"UniProtKB:Q14832"}
{"id":"075eb24e-fc9c-4b08-b48e-4af31f8cd3fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93046","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:7cfbdf1d-3c04-4ac6-9778-6b9370ebd672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1389","original_object":"UniProtKB:Q13255"}
{"id":"a360af08-306a-4208-98de-8822d6bcca96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:928","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:d7febdb7-a451-4352-81b9-f9507d245079","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:928","original_object":"UniProtKB:Q60748"}
{"id":"ac14f910-c45d-4ddd-beed-d1c9ba68ea60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19077556","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:52d686af-b12f-4849-a644-46d32fa2c854","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3093","original_object":"UniProtKB:Q02769"}
{"id":"3d630acf-178c-4fd4-b4e9-1a138186dc00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104929","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:7dbfc867-3a9d-42b6-9b1e-a6c9919280e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:879","original_object":"UniProtKB:P32239"}
{"id":"69dded77-ad12-4295-b0c1-f325def80a1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91450","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:e7c145f3-1abb-4c8c-9698-db60c6b1c97f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7933","original_object":"UniProtKB:P48736"}
{"id":"972c4016-0e10-486c-9d9b-a445339ed725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15931446","predicate":"biolink:affects","object":"NCBIGene:3632","sources":[{"id":"urn:uuid:a8a6072c-a16b-49f7-a8ba-242bf99ef598","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8844","original_object":"UniProtKB:Q14642"}
{"id":"03e1703b-95de-4a08-b2f0-83ddf1da44d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:4712d0da-736a-449a-9a10-8aaf9e8cb41b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P47898"}
{"id":"fb406ebd-bd72-4289-a62a-273c97f72d6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0G7D0CQ88I","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:37eb09dc-fb41-4921-ba1b-721088a188bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7721","original_object":"UniProtKB:O43497"}
{"id":"a1e97c3c-be27-4ede-8812-2c6c49b8e9b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11756374","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:5be93bf5-34e6-4e15-a0fb-e83d301a3e28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3030","original_object":"UniProtKB:P51639"}
{"id":"986b29da-8dcb-42d2-86e2-692fa4d83b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:9429","sources":[{"id":"urn:uuid:ff5292ec-e635-46fd-a500-4b9dd9b25aae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:Q9UNQ0"}
{"id":"f59d784d-7787-4c85-85a1-b863b968a474","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136232645","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:914bde56-31d7-4918-84c1-688da0cc4109","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13752","original_object":"UniProtKB:P36897"}
{"id":"f34846f0-39c9-4c11-b974-cae357ea8b88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11260","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:4dff71ab-7a3f-4a42-80e7-951d288fb7bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11260","original_object":"UniProtKB:P30550"}
{"id":"173d8b6e-6b1d-446e-b88f-eba4308b2122","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:12289","sources":[{"id":"urn:uuid:d14bf670-3f4f-484e-be3f-a7679cc4b255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q99246"}
{"id":"e7ddd3de-1fb5-4715-b90d-bdabae9cb422","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG8BT6T9MB","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:25a118d2-4661-46fa-9832-108278c0ce14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5993","original_object":"UniProtKB:P23458"}
{"id":"7d962a07-47de-42c8-b5cc-438ca08f7efd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146277756","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:09e1748a-e47e-4c74-8847-6c93191d9276","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12881","original_object":"UniProtKB:P11802"}
{"id":"e52af966-891f-4dac-8d2b-07f0ba14eec0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54760385","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:39e4f58b-536b-47a8-8c96-a4f66a91b177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12089","original_object":"UniProtKB:P36888"}
{"id":"01e285f7-65e4-4b3a-aec7-a0117e1d8608","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:507","predicate":"biolink:affects","object":"UniProtKB:P15823","sources":[{"id":"urn:uuid:188f13e5-6e8b-4146-a8b1-6047cf9d2576","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:507","original_object":"UniProtKB:P15823"}
{"id":"d42bb7dd-1f38-4127-b2f3-cfbd9e83d3de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TD3SSC2VDF","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:9f13ac68-1516-4d32-b13b-d5380cc62253","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11959","original_object":"UniProtKB:P18825"}
{"id":"30e79c9d-c02e-4f2a-919f-c724e0658590","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44658","predicate":"biolink:affects","object":"NCBIGene:5499","sources":[{"id":"urn:uuid:3a0b8364-da3b-4047-9fc3-394e8b2abe92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5349","original_object":"UniProtKB:P62136"}
{"id":"abeffe1f-5986-4ac8-bfdd-459c186879f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177616","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:c5d6abde-d77c-4aa4-9edb-c619623d2c9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2488","original_object":"UniProtKB:Q8TDV5"}
{"id":"0e24990d-5ab5-4f0c-b8ce-c5433b827ff7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5834","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:1b2ca6f7-5f97-4377-a91b-5c2f4422cf76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2764","original_object":"UniProtKB:O75469"}
{"id":"d0502fd2-00be-4bb3-9137-24c30ec34e35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24858111","predicate":"biolink:affects","object":"NCBIGene:1786","sources":[{"id":"urn:uuid:e7b9f99e-ca7f-46b3-b08a-17330c113e42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8891","original_object":"UniProtKB:P26358"}
{"id":"cbadd252-9dc3-4ea2-9694-34207c146902","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993656","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:2254e2a9-9caf-4f93-96f7-c06baacd84d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12571","original_object":"UniProtKB:Q9Y5N1"}
{"id":"cb68e217-963b-4170-8768-57105bb6ac46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9963005","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:bb2c361c-d80f-40d2-a885-0786c26f9cf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1679","original_object":"UniProtKB:P41146"}
{"id":"cbe937b2-2cf1-402f-9592-cce15cf30853","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73044","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:64e2ad53-f63e-422b-8663-3c02be5aeb3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2897","original_object":"UniProtKB:P35354"}
{"id":"a0e578a9-5577-420a-8c3f-61f0abb574d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1326","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:4cf27677-c8c2-460d-8c24-0cd625064d4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1326","original_object":"UniProtKB:Q01726"}
{"id":"7be52c7d-d84f-4f36-8630-08fbc8a7d01c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67WJC4Y2QY","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:46fe8c30-0253-464b-8205-e05f5d3f30dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:163","original_object":"UniProtKB:P41595"}
{"id":"c23bac8a-306b-4771-bd6c-99d854428817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:a7bf4da8-ea1a-43f2-b7ca-8ff68f002fa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:O95977"}
{"id":"cac7061e-1907-4619-b1f5-155e54851837","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3176","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:a70d85ae-ecab-40ab-8246-7451a5f25234","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6797","original_object":"UniProtKB:O43570"}
{"id":"a6a8676e-54a6-4da7-80ef-44cb090ad6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13287","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:28b2f838-db96-43ba-8bf6-90bb862916ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13287","original_object":"UniProtKB:P21554"}
{"id":"f2b31730-f570-4a94-a2f0-4f7ca5e8ff63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FF33NL9U5G","predicate":"biolink:affects","object":"NCBIGene:208188","sources":[{"id":"urn:uuid:0b6e2f7a-c83e-4f49-86ef-4090e4d0465c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9060","original_object":"UniProtKB:Q99P50"}
{"id":"31f499ff-5f69-4714-884b-8c2c4b572a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4284209","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:a33e509f-0f80-450c-9436-cdd38e4610f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10081","original_object":"UniProtKB:P06493"}
{"id":"d62fa521-c5ef-4e2f-aec6-70d32122e257","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86329","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:57b5faf4-fef8-4980-967c-e646c8204245","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6296","original_object":"UniProtKB:O75762"}
{"id":"39800afe-3533-4541-8b20-e9847137e5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321149","predicate":"biolink:affects","object":"NCBIGene:5802","sources":[{"id":"urn:uuid:4a04389d-ade3-46d4-9709-defdb97f0880","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10109","original_object":"UniProtKB:Q13332"}
{"id":"c639ed0d-8041-4348-93ad-6eb3169f9642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233306","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:efc64c00-4417-48a1-b0a2-f39a19235043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13067","original_object":"UniProtKB:P23443"}
{"id":"382023c0-44f6-4422-bb42-d7e7fa1b2067","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1326","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:c1a504ce-2fb4-4553-b250-96d691c40dc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1326","original_object":"UniProtKB:P32245"}
{"id":"d823434d-ec1d-4f92-8a58-1a3e1157e67f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2546","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:84a1d24a-c648-4df5-bd93-4844735f52a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2546","original_object":"UniProtKB:P16388"}
{"id":"6f703f0a-f5c9-4c5d-a4d0-434c86b3204e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122390213","predicate":"biolink:affects","object":"NCBIGene:221955","sources":[{"id":"urn:uuid:29326bbc-c067-4728-a075-a33ebdb87c1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10246","original_object":"UniProtKB:Q8NCG7"}
{"id":"acc51f8d-ccd8-4557-8a5a-b8227e3fd71d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SEF6R39DDK","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:4d43c015-fa84-4e2b-80b5-6060138d371f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6726","original_object":"UniProtKB:P17764"}
{"id":"7ec84e95-6b67-4671-b230-f06060163f6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DL772G3NN7","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:f8bff2c9-f813-4111-b32a-8ef7859897c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13213","original_object":"UniProtKB:P12931"}
{"id":"f3df1274-c5ba-4e8a-aec6-992bc2de486a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368935","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:8e0386e8-14b0-4ae0-94d7-8c76a31d4cfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12179","original_object":"UniProtKB:Q9UBN7"}
{"id":"131cd49e-8eaf-440d-92ab-3ece1ed9458d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9408","predicate":"biolink:affects","object":"NCBIGene:7097","sources":[{"id":"urn:uuid:910bc174-738a-4be8-be54-236a0e46db0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9408","original_object":"UniProtKB:O60603"}
{"id":"ac9e32b3-69fc-466f-9acf-829bcd2ab42f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5128451","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:9f6cd0b8-c100-4f0e-a45c-f19c6d79a6ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:646","original_object":"UniProtKB:P32299"}
{"id":"b87fbe1a-104a-4152-9904-e6d2b6aa7679","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:809","predicate":"biolink:affects","object":"NCBIGene:1235","sources":[{"id":"urn:uuid:0e5eaf76-e277-44fd-adfa-663a21ef76de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:809","original_object":"UniProtKB:P51684"}
{"id":"66d1227d-7f55-4e99-ae94-bef1bca07f1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17066","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:8bba8068-f013-4d69-9a40-c6befbf551c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1593","original_object":"UniProtKB:Q8TDS4"}
{"id":"15aa5f37-a54a-463c-a1e5-332849b8c178","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63626","predicate":"biolink:affects","object":"NCBIGene:2692","sources":[{"id":"urn:uuid:623ec0d1-15ce-4d57-a085-438ee2e87281","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6959","original_object":"UniProtKB:Q02643"}
{"id":"8a8c3fb3-533d-4d2d-9f81-c07e1940ebe1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030535","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:c30ca69e-2c21-4d74-9e1f-6dfbf7bf03dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10489","original_object":"UniProtKB:P42338"}
{"id":"f2213e13-5bed-477b-a53e-6069bc9b4316","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56968001","predicate":"biolink:affects","object":"NCBIGene:31","sources":[{"id":"urn:uuid:5602d44e-3914-4a0d-bcd5-fcc1e36f8d75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8884","original_object":"UniProtKB:Q13085"}
{"id":"45624ca3-7104-4392-ab12-80b433f226b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M18T0TD14","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:3d788b04-4541-467b-a286-50c4cd34b4be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1620","original_object":"UniProtKB:P41143"}
{"id":"18624ffd-f18f-4f7e-b4d2-fb80fcebd66d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:02HQ4TYQ60","predicate":"biolink:affects","object":"NCBIGene:4312","sources":[{"id":"urn:uuid:f55ff37b-c444-4ab2-bbe9-e559a7d9465a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6466","original_object":"UniProtKB:P03956"}
{"id":"d49eddb4-11de-4ff8-8145-98cc40315979","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4945","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:47b8ff5f-f81f-4794-a06b-8a3244c23fe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4945","original_object":"UniProtKB:P25092"}
{"id":"95e1bb1a-cde0-41bf-bbcf-9d90161d5639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9741","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:fdd2ffce-3fff-47db-b32a-638825e4016d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7318","original_object":"UniProtKB:P35367"}
{"id":"e8db4770-ac8f-43de-8d88-06f6f751a4b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50186","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:aeee2c76-c070-4914-ae22-32bdef56f385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2920","original_object":"UniProtKB:Q9HC97"}
{"id":"cd6e3047-4dc4-4aac-a640-37c3556cbefc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827364","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:1beb29cb-4e60-4480-bd4e-7079b6ffbae6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8507","original_object":"UniProtKB:P32247"}
{"id":"24d45f21-133f-4f05-add8-6bcf5f2746fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118694559","predicate":"biolink:affects","object":"NCBIGene:227289","sources":[{"id":"urn:uuid:bc628c1c-42fc-4ab2-a843-85de4da71956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12906","original_object":"UniProtKB:Q80SS6"}
{"id":"ecf46252-563d-49d4-a59a-8e95c082c4ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9757","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:6ea77fe6-3b92-472d-9b2c-e733eb908759","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7319","original_object":"UniProtKB:P08172"}
{"id":"55aa4a30-3884-4d6d-a681-d09cef0ed5de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R3734K0M7L","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:6db4319c-a10b-4148-8542-959c32b19edb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7411","original_object":"UniProtKB:P15121"}
{"id":"0943c5e6-838f-4c51-8e20-be1851848345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95073","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:6c732947-cb7f-41e9-99cc-569c5d914124","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7010","original_object":"UniProtKB:O15379"}
{"id":"72fbc2ae-14e8-4913-962e-b40804551c1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:4323","sources":[{"id":"urn:uuid:5a8503a0-be18-4f4c-811a-1965cffe50fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:P50281"}
{"id":"251e5c88-b0ab-43e3-bbb3-918c8189b827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63451","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:090a263a-6a9f-4f62-86e7-fe4dc123b55b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7877","original_object":"UniProtKB:P21802"}
{"id":"a1539e3b-e77a-47cc-b833-9143699906dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2767151","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:2ca255ea-039e-4f80-a525-8c6d7885e3d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12539","original_object":"UniProtKB:Q9NZQ8"}
{"id":"e54b90a7-aef2-49b2-868e-4c8ac05fd43b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:ef6bcb4b-8c39-4756-8196-9e538f7aa4d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P12931"}
{"id":"dd6e324d-b149-4404-86c0-088c22b91125","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993650","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:413cabef-14d2-4937-a11d-5449dcf1edba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12532","original_object":"UniProtKB:Q9Y210"}
{"id":"d55a087b-d007-4ac7-a68c-f8946a910b83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:8dec3aab-01c9-4343-ae88-2cc463365aba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P35367"}
{"id":"0dff9055-5542-4123-ac81-09d668a156be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155884491","predicate":"biolink:affects","object":"NCBIGene:9361","sources":[{"id":"urn:uuid:cdb53645-0531-44fc-b5b7-c749da38071c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11505","original_object":"UniProtKB:P36776"}
{"id":"3996c9a3-ac34-4ddb-b595-2689b4c6ef12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25175634","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:e9bd6737-c23e-4f5e-8fdd-89232cd0a426","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5457","original_object":"UniProtKB:Q923Y8"}
{"id":"6fd39dc6-4b17-46b1-bc4a-00b8300a283f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131345","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:78634574-fcc8-4508-b775-e2b6c24ea448","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2511","original_object":"UniProtKB:P22002"}
{"id":"f6c6ea5c-e2da-409a-b9ee-55d90dce308a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2275","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:f4a853c0-0343-4e5e-a8fd-3312a85724e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2275","original_object":"UniProtKB:P32241"}
{"id":"c9185592-0a90-41ef-aaa4-b95c7b2f5231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82701","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:9a90c5b5-1420-47d1-b01c-e473008fe41a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6741","original_object":"UniProtKB:P42336"}
{"id":"016d7ca0-5a42-48f9-9df8-bbc8f62b37f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35056","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:be3ce310-ece8-4481-856a-bdd28d803458","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4093","original_object":"UniProtKB:P56373"}
{"id":"e71a90fe-a6cd-471f-b5a7-dfb8d28b2521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4Y3VYY2X83","predicate":"biolink:affects","object":"NCBIGene:5607","sources":[{"id":"urn:uuid:7c5d7294-bc11-44d4-b8a9-f1845302def0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8064","original_object":"UniProtKB:Q13163"}
{"id":"e4ea157f-0ce2-4cf0-b522-c203ecd301d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16393","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:451e93bc-08c5-445a-8799-49748d36ba65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2452","original_object":"UniProtKB:Q9HCF6"}
{"id":"3dd1cc71-ac33-4a9d-b275-6a6996252870","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:3055","sources":[{"id":"urn:uuid:c43d3eeb-ddf7-4287-acdc-6efc52f387a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P08631"}
{"id":"209dea26-c66b-4fcf-a61f-d561cf3935eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:4f7174d1-a6d2-4010-ac9f-6d081b929e8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:P53667"}
{"id":"6c8905ac-dd03-4a96-9a1e-75ac09f77f72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755068","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:217357cd-5868-45d3-946e-8aa6a97ed01e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4029","original_object":"UniProtKB:Q9Y2T6"}
{"id":"a593e112-7b82-46d7-b009-33542ed3e7e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2164238","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:66db86b2-e73b-4542-a259-4858847221e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6717","original_object":"UniProtKB:P48449"}
{"id":"227209f7-88bf-41bb-bd4c-6ca5f029c950","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:63Q7F59W0V","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:312a2ed0-d3b1-412d-8f34-3e956df8e564","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11687","original_object":"UniProtKB:P50750"}
{"id":"11d7f4cf-c085-4db8-a402-147addb73845","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827371","predicate":"biolink:affects","object":"NCBIGene:5550","sources":[{"id":"urn:uuid:8af1d7a2-45d3-4cb8-a1e1-8b2b646dccc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8564","original_object":"UniProtKB:P48147"}
{"id":"dd2e47a7-17a3-43d1-a90c-fb3427f95ba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16138722","predicate":"biolink:affects","object":"NCBIGene:70008","sources":[{"id":"urn:uuid:7d7aa382-0d9e-4866-bb7a-2c70e4fe7fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11602","original_object":"UniProtKB:Q8R0I0"}
{"id":"40898f68-938a-49a8-8348-54ab56a51a7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5299","predicate":"biolink:affects","object":"NCBIGene:835","sources":[{"id":"urn:uuid:4194ddc8-c9c2-40fc-b31d-78d1ac08d3c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5299","original_object":"UniProtKB:P42575"}
{"id":"96ec668a-5e4c-46f3-9421-e57b4f47a0f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:92cfe741-c9e8-4df7-9f06-f1a27cd5e82e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2340","original_object":"UniProtKB:P15387"}
{"id":"8dc638e3-46d5-4bf7-9292-8653e7230724","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:3df1cf02-c08f-4a07-aea3-cfc8c1bea4e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P20309"}
{"id":"4c49cbc2-f01b-4084-94c9-1a3cea2ae685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:cb7a2d73-c629-4407-ad68-bef8e2e25480","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P50406"}
{"id":"437f064f-dfe2-4c62-8b7e-36b4e8b0387d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604840","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:cfa00f64-7dde-4ba4-9322-7867167940f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:126","original_object":"UniProtKB:P28221"}
{"id":"6a602b4e-e3de-4699-be46-5819fa084c1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1170","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:c2a4cb6b-6f78-4eaa-8b17-599c42ed4a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1170","original_object":"UniProtKB:P30968"}
{"id":"ea1f81a6-95b6-4285-a8d8-79d87739a68f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:118acee8-7f9a-4432-996f-e47e39959f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P28335"}
{"id":"7ab3bcc3-621b-4994-817d-d976cb2ce8bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:4de71a6b-0da9-4d3e-8690-532f79dc6c37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P08909"}
{"id":"b12da954-fa06-4216-9137-c74947c4adf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2188","predicate":"biolink:affects","object":"UniProtKB:P48974","sources":[{"id":"urn:uuid:9d27db40-2d78-400e-b261-75a2fb7c1ed0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2188","original_object":"UniProtKB:P48974"}
{"id":"dae17a3c-69a4-45e3-9b63-40490bd7984e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755066","predicate":"biolink:affects","object":"NCBIGene:1138","sources":[{"id":"urn:uuid:7b7c3782-ca2d-4124-acc3-f105b2db34fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3982","original_object":"UniProtKB:P30532"}
{"id":"11b71f24-67c8-4b4e-b8e9-72c0eb6bb022","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118981713","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:3bcca091-3eb3-403f-ac71-d6f5f231c5ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12156","original_object":"UniProtKB:Q13224"}
{"id":"c9aef04a-69e0-4e58-94dd-c3cfd8f5ac50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41922","predicate":"biolink:affects","object":"NCBIGene:26379","sources":[{"id":"urn:uuid:a9e91c41-0b53-4584-99eb-cf2f400763f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2801","original_object":"UniProtKB:O08580"}
{"id":"a78bb08c-f244-46ea-82dc-865d2db5ad2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2190","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:56e80d84-5912-403a-9825-edd2aed35a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2190","original_object":"UniProtKB:P30559"}
{"id":"4014434c-310e-4278-9cf9-c51a999075ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146025594","predicate":"biolink:affects","object":"NCBIGene:9446","sources":[{"id":"urn:uuid:11519c80-cde5-4a8e-a732-d47bf1953be0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10718","original_object":"UniProtKB:P78417"}
{"id":"cd87165d-2811-4602-a0f9-fef0e1c63e66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9C8MNF7CA","predicate":"biolink:affects","object":"NCBIGene:13983","sources":[{"id":"urn:uuid:25e70ea1-69cc-45d3-b26d-0eadb335d18f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6700","original_object":"UniProtKB:O08537"}
{"id":"0503a94d-b7eb-4d1d-9899-d7bf3769ac10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827372","predicate":"biolink:affects","object":"NCBIGene:29117","sources":[{"id":"urn:uuid:d0fa8856-2f8c-4751-819c-e8d5c08c3921","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8572","original_object":"UniProtKB:Q9NPI1"}
{"id":"344b8021-07a9-416d-84d5-9ea33881250c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131358","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:9c9add1d-463d-4405-80e9-bd83d1dd966c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3289","original_object":"UniProtKB:P29274"}
{"id":"eeda01ee-38de-4a39-91f7-e6a3f8a74de2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53115","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:3d097685-9fb7-40b6-94c0-677b94a0bd4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5609","original_object":"UniProtKB:P29276"}
{"id":"dcefad9c-9cf1-4acd-8d98-6d3448a32b24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:c8bd54f9-4e0b-44a5-85c1-71fd7867c965","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P14842"}
{"id":"f112a802-66d3-4340-b6c8-806c64cc3a77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47499","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:d9d11250-890e-4503-bfd6-bc39f97f8cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:357","original_object":"UniProtKB:O95259"}
{"id":"b10dbc80-39d5-40fe-a790-6a52ba3329fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191073","predicate":"biolink:affects","object":"NCBIGene:22067","sources":[{"id":"urn:uuid:e1c78f39-0cc6-4f75-83b8-1d4afa576dab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5149","original_object":"UniProtKB:Q9QX29"}
{"id":"6f944a01-ca3a-49be-906a-a86ebfde06db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10390222","predicate":"biolink:affects","object":"NCBIGene:6572","sources":[{"id":"urn:uuid:6ab79623-e2ac-40d5-9dcb-529094c33bad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4768","original_object":"UniProtKB:Q16572"}
{"id":"45b47295-1faa-4a08-8277-4d806cd64bb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118335773","predicate":"biolink:affects","object":"NCBIGene:4323","sources":[{"id":"urn:uuid:6dd5997c-b98e-4b15-b65c-96af3d697de0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10887","original_object":"UniProtKB:P50281"}
{"id":"46069beb-f172-4e0a-9155-dcae76bfce42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9107","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:0ba870f9-8c5a-4882-ba5a-8fc8cd592240","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9107","original_object":"UniProtKB:P07333"}
{"id":"b98fc5b1-2b01-4c62-84cd-26a757c2d18e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6184","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:3f41e221-ce8c-453d-8c6e-15444483d140","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6184","original_object":"UniProtKB:P30550"}
{"id":"3db6e0ff-8a0c-4dff-8890-364b4a6bc38c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13785","predicate":"biolink:affects","object":"NCBIGene:3566","sources":[{"id":"urn:uuid:b872e33f-fa7d-4c3f-af9d-ab77ddc7dc29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13785","original_object":"UniProtKB:P24394"}
{"id":"ebf2acb2-329c-442c-a2f2-d16cfd812995","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:2db82ea8-9008-4286-87bc-8ad657b2af14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:P70597"}
{"id":"7f3bcdbe-779f-457a-92fd-93192f3d4a80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:5c78a81f-a0d6-414c-966e-fec290c0971f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P28222"}
{"id":"38753d03-6870-45b6-a80f-5b4ca935798b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:5e7e4b40-842f-4513-939b-febc48a98d6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P23415"}
{"id":"2fe5500f-f2b2-41c4-9b6e-1ee8bc5aa82e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5648","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:fd10f4db-a180-4971-9fd0-5ad5f4037f2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5648","original_object":"UniProtKB:P30874"}
{"id":"c23fe2ca-882d-461d-885c-1e7c6538aa9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:931L4X5WMM","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:80e98421-16a3-4555-80a8-96b0c6905e5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1226","original_object":"UniProtKB:P35367"}
{"id":"d986cbca-8eaa-4999-af16-a48be48aef02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:25187","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:21684ba8-a6b2-4e9e-818e-b5868b347a0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2471","original_object":"UniProtKB:Q8R4D5"}
{"id":"c971b043-58cb-4d23-b615-e7801e9f5d14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44354318","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:abd15180-265f-4a8f-b592-6ad95d82417b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3113","original_object":"UniProtKB:Q02769"}
{"id":"a7822d5e-a280-48fd-b15e-5cd925c2837f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71529752","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:1fe0bdf5-4210-40ec-9bdd-00576ca890c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8165","original_object":"UniProtKB:Q9Y463"}
{"id":"d6b84d72-d4bb-45e6-abfe-685a17dd0807","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124991","predicate":"biolink:affects","object":"NCBIGene:55867","sources":[{"id":"urn:uuid:05096138-3f35-448a-8155-6e3a5ceb32f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8798","original_object":"UniProtKB:Q9NSA0"}
{"id":"90341db9-c4ee-4033-ae62-b86ab2e5dc0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11461","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:211a2659-4d2c-4510-9bfc-f93a9fce8987","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11461","original_object":"UniProtKB:Q9NSD7"}
{"id":"1bde91eb-9fe5-4414-88ec-4f9185d253bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699456","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:79b246f4-ef37-40c6-9fa7-95e529fc36d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11196","original_object":"UniProtKB:P48039"}
{"id":"655072bf-85b6-433e-98a4-fc841a31c94e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15118529","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:b01c9bd7-d485-43ad-b607-84b5343fc4a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:340","original_object":"UniProtKB:P08172"}
{"id":"24390222-b42b-417e-a13e-e9f6aec1d49f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3650","predicate":"biolink:affects","object":"NCBIGene:6833","sources":[{"id":"urn:uuid:71d38920-bc86-4597-a865-f51a1c3ca3e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6801","original_object":"UniProtKB:Q09428"}
{"id":"c24de102-53f3-4aa4-a366-b14cf2b237a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169298607","predicate":"biolink:affects","object":"NCBIGene:124976","sources":[{"id":"urn:uuid:b93b7b15-0007-49eb-9271-38b0aba49053","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13436","original_object":"UniProtKB:Q8IVW8"}
{"id":"8fc4f07d-3a8b-4335-9aaa-9cf923a56d25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1804","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:e944ba42-06d5-4414-bd6e-da70d2740c45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1804","original_object":"UniProtKB:Q03431"}
{"id":"5083fa6b-323c-4cc0-8863-b005de9a5bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3656841","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:42e092a6-25ed-4338-bb80-8fc52da980d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8053","original_object":"UniProtKB:P50750"}
{"id":"d2cc24a3-03be-48ad-9ff3-52e33a11a02a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:8ca0edec-787c-42b8-bf86-6b7893c49ec2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:Q02156"}
{"id":"1c996e52-770f-4102-9b2f-801fa1a1f421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:bfd11edd-30c6-4017-a1b8-cb0a64267ae7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q9BY41"}
{"id":"feb18d40-a759-4ddb-be65-5e7205c3c11d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1527","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:8b687b55-8ede-49f4-8623-51a29f29e4e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1527","original_object":"UniProtKB:Q63634"}
{"id":"652cb071-301d-4383-82df-30b258395be6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1285941","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:8f7b1432-cd19-4517-973d-3a4a65de394f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7004","original_object":"UniProtKB:Q09472"}
{"id":"016e9e94-e4ad-4c96-bf28-0d7725f84716","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:ca40c4c4-a5f0-4306-8ec8-633383773c9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P28222"}
{"id":"f22a7a91-c733-4dd8-a152-8a41b04fb8b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6082","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:9079d516-5377-45d7-9e04-8fd0e81b6424","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6082","original_object":"UniProtKB:O08726"}
{"id":"501702ee-b331-4850-a620-3270bc9f391a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60782","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:6a22641f-e4d0-4c56-9762-04eb3675d996","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1940","original_object":"UniProtKB:P21731"}
{"id":"1829145a-6b4a-4f3e-9d8d-f91b877e230b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2857","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:2f419f5d-954a-4f34-8391-087d187d8515","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5956","original_object":"UniProtKB:P00533"}
{"id":"27090e6f-bc76-493a-9bc4-7398212725d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71566654","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:5019919e-8e9e-4367-bfa3-165d8efff31f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9449","original_object":"UniProtKB:Q16581"}
{"id":"e26007d2-6df0-4b5e-9ffa-8b1e08b8c5e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:7553d36f-0f8a-4683-9c37-76841d6fab7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P41595"}
{"id":"3ab01865-0715-4897-981b-762cbbbbdda1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3084","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:64043cc7-8f41-4779-8a89-3bfbac773ce3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:297","original_object":"UniProtKB:P20309"}
{"id":"7418b849-cb88-41db-9d70-fb06898dc080","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70726","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:a2ee3c65-1271-49e4-b05d-8375da776733","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8354","original_object":"UniProtKB:Q96GD4"}
{"id":"d03d45cf-e3cb-4770-ac88-6e262abdf0eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2583","predicate":"biolink:affects","object":"NCBIGene:65195","sources":[{"id":"urn:uuid:d804d260-fc3f-4b8b-987b-0ba63651b006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2583","original_object":"UniProtKB:Q62897"}
{"id":"27a0337b-fa4e-4470-832e-aa926ac61ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2807230","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:650fd019-ee2f-4441-af92-fa638805a134","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13478","original_object":"UniProtKB:P0DTD1"}
{"id":"c16b1bef-dbe1-4e12-b53a-990d5929e6f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817381","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:0114ae3e-e2b7-43fb-9cdc-dee91c920db2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:690","original_object":"UniProtKB:P30988"}
{"id":"b24db280-2033-4adb-ad1d-c54659e6e7d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:2268","sources":[{"id":"urn:uuid:26d3a4cc-c223-4ad8-9c9f-59e516cd4bcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P09769"}
{"id":"4526993a-bb32-4410-b62d-1c808d9ba457","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11629817","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:9949ada8-349f-4693-b996-7fd56a457c2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4099","original_object":"UniProtKB:A8MPY1"}
{"id":"588022e2-a6d9-46b6-a6f7-fc5abbf1d1e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71267445","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:cfa6acee-2f13-45ec-a69f-93719f209719","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12888","original_object":"UniProtKB:O14684"}
{"id":"c9c5558d-0aef-4810-94c4-f13c84e16099","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94981","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:e16519fd-7310-40f0-a50a-676c5108ffe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:254","original_object":"UniProtKB:Q13639"}
{"id":"8706cf79-be66-4ad3-b879-824077da60ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92624","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:8eaeb1ca-d847-46b0-909e-4e3c7083fda9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:890","original_object":"UniProtKB:P32238"}
{"id":"dfadc72e-58d4-4b9c-ab6d-5117ecac55b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:738951","predicate":"biolink:affects","object":"NCBIGene:123228","sources":[{"id":"urn:uuid:8f15c40b-369e-4991-b57a-765b4f904953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6539","original_object":"UniProtKB:Q96LD8"}
{"id":"442a4063-9349-48f3-806d-080e84161d08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91963","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:b1d4a491-a058-4336-990c-6c710586bd48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5242","original_object":"UniProtKB:P42574"}
{"id":"e6ca946d-9610-4db4-a63c-30b7694997a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:721a2650-8d9e-4b18-ad0c-34a1fe126681","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P21728"}
{"id":"f5d3a6a7-2978-4683-96e8-c641d40fce2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817439","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:b891ef0f-0bf0-4e62-9c07-5db9d6082640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2382","original_object":"UniProtKB:P35560"}
{"id":"00a76629-89ac-4898-9444-35275e4fbc1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11622683","predicate":"biolink:affects","object":"NCBIGene:6505","sources":[{"id":"urn:uuid:2129f18e-9e40-4f85-9454-16f96b6f947a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4625","original_object":"UniProtKB:P43005"}
{"id":"5f4e013b-5128-4488-8ea8-8aee65277fef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31859","predicate":"biolink:affects","object":"NCBIGene:24898","sources":[{"id":"urn:uuid:7302ec5e-ba9e-44ea-9f3e-018c3838a069","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7555","original_object":"UniProtKB:P23977"}
{"id":"33244562-1ad1-4c14-8c4f-6d3a318cff97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125535","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:be9d50be-c432-4224-8b53-fb1e5152cd3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4808","original_object":"UniProtKB:P23975"}
{"id":"4be62734-d58a-4b67-87b8-44b31653f2a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321155","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:41bfe95a-61a7-4e76-b49a-438069be139f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10147","original_object":"UniProtKB:O60674"}
{"id":"8b492298-cf1e-4dd9-8b88-1e08c8df9e51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:1b46249f-30c7-4159-951a-d68d7c7d36d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:O60674"}
{"id":"490308f5-a785-4ed9-a7c5-8acb5429c900","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46229","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:87685e12-8ae5-4c4b-9456-568e67be4126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1783","original_object":"UniProtKB:Q6NS65"}
{"id":"81e48355-2df3-46ff-96d6-a6bed0612c40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6185","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:bea73a2a-9860-44ef-ae47-2c0d29039ba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6185","original_object":"UniProtKB:P30550"}
{"id":"28008ed2-1883-4432-bdf6-4242e44e006a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:62715191","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:6be6e553-bea3-4c3e-8bf6-04f98c8632d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10187","original_object":"UniProtKB:Q96RI1"}
{"id":"61d7b936-2ed8-4a31-93b4-79e658784125","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92230","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:f29ff319-2103-4a1e-8f81-5e72866bed0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:954","original_object":"UniProtKB:P35462"}
{"id":"9326c48b-8263-461b-b0fc-b9dccba7e480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63634","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:bfb2f660-e71a-42e8-ac64-d84389c4ee9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2894","original_object":"UniProtKB:P35354"}
{"id":"4573bff5-0d42-4a6a-a16f-a42c74ba1da7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:5b43ac8c-525d-4c93-bab9-a39dbea11d86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P21731"}
{"id":"d1418e60-8bdc-48a6-aaae-2423fc7e06f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11462","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:73d50131-ebae-4001-93d1-58946cd7627c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11462","original_object":"UniProtKB:Q9HBX9"}
{"id":"093cdf17-5c6f-45fa-8e5a-581b8fdb930a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25025860","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:b0c312ac-3434-430b-9b41-fc5e0e9576aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6188","original_object":"UniProtKB:P32247"}
{"id":"de241e83-3c5a-411c-9703-e71332244d85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59560","predicate":"biolink:affects","object":"NCBIGene:5053","sources":[{"id":"urn:uuid:6b4e5114-06d8-4861-bcf6-9fcdbac5f82a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5276","original_object":"UniProtKB:P00439"}
{"id":"556102f2-9b46-4b37-9cd9-1331bd1921fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35003","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:c7fbf1bc-acb8-4d26-8c52-ad82a2454277","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4068","original_object":"UniProtKB:Q05586"}
{"id":"eeeb42d4-1092-4dd7-ae73-df47294dc929","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122190433","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:38a6976e-ef84-4a99-a3af-25e784a34a2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10237","original_object":"UniProtKB:Q14832"}
{"id":"ee55c390-e67e-4189-9e86-bf43d260b885","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567102","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:a29d956f-2930-4a41-882b-e022bd8b12a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12661","original_object":"UniProtKB:O95835"}
{"id":"21a575d7-8d05-4a02-ae95-7aea079aad28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66558287","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:6ae7dcdd-0a4a-4f7b-98dc-bc2e1159510e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9019","original_object":"UniProtKB:P14902"}
{"id":"025da780-1a2a-428f-a8a1-559b11ffbfec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124090478","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:bc74141a-a767-4b46-a935-6ed24dc8473b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10458","original_object":"UniProtKB:O60674"}
{"id":"65d178c6-5527-4d6a-8f39-949c0a6522a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78540","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:73bd1c3d-93c6-4feb-82a7-321adc3286a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7372","original_object":"UniProtKB:Q07343"}
{"id":"2a49cabf-0f76-4c77-8f5f-19e5106c1001","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947043","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:afdf5437-5ff1-4c8c-ac2a-ed09094ac616","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2983","original_object":"UniProtKB:P51639"}
{"id":"c2f3c580-c9f8-4752-aab7-3606c63b2547","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DA64T2C2IO","predicate":"biolink:affects","object":"NCBIGene:4070","sources":[{"id":"urn:uuid:366716f7-f305-4b94-b65c-1850c4cda819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8253","original_object":"UniProtKB:P09758"}
{"id":"1ecd1504-5bb9-49a8-9433-e1c1dafc374b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:fed938b1-eb84-484c-a095-d53f8af41167","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P07333"}
{"id":"23af77b0-7ebf-4dc0-9e47-3a1e8122af79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:72c4f1aa-4abb-43d4-b83c-feda6e53bdda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P35348"}
{"id":"24e55519-a549-4116-a69b-10a8b64da27e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34605","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:73a2f82f-0587-4d0e-8ee1-7b85901f8929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4165","original_object":"UniProtKB:P42263"}
{"id":"2b36d5c6-78b8-48b7-9f51-8965126e2d05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10138707","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:e0df2e09-d385-4e36-9287-515cedb64ce7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6711","original_object":"UniProtKB:P48449"}
{"id":"98ee05f2-308e-40a2-93ca-df78631372a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17677","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:c469f50c-ea3f-4d1a-80ec-6cfb10bbd824","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1741","original_object":"UniProtKB:O35811"}
{"id":"d0377fdc-5256-4d89-b957-e9c9b93f5d2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5RV7T5BNMG","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:84434e61-dd14-4a62-85cd-793bb1049edd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8984","original_object":"UniProtKB:Q9Y5N1"}
{"id":"102a7987-cbce-4ff7-a886-5d98488c39f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10221","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:5a0c6063-1c06-4667-9741-c2b242d4a741","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10221","original_object":"UniProtKB:P32238"}
{"id":"487c9f00-67ad-4651-a4a9-10f65cb76272","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:434db2d7-ad85-48d6-9cbe-19dcc4a3e288","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:347","original_object":"UniProtKB:P11229"}
{"id":"8606e12f-f338-4137-bae8-00e5b7fe157a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34968","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:18531ad3-1ed5-44b8-a3f8-36d480be0289","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4197","original_object":"UniProtKB:P14867"}
{"id":"5a4dc795-6e8b-436e-b287-9c60746b6140","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:56547","sources":[{"id":"urn:uuid:0ca4925b-ab11-4c02-a8f3-e223e735929a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:Q9NRE1"}
{"id":"61a57834-ea57-4235-a1ad-e85f1fe6215a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4312","sources":[{"id":"urn:uuid:39ff4162-da80-4a9b-9402-b062aba2af72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P03956"}
{"id":"b8e0e28e-7f39-4c21-989f-57e5ebef99d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6917952","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:e1ef4774-fb41-4dc7-a4f0-b931199c704f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2223","original_object":"UniProtKB:P47901"}
{"id":"51deadcd-9278-4ff6-b1f1-296d0a10fbf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42608431","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:062ffbbb-d80e-43ec-96f2-26b66c2624d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3926","original_object":"UniProtKB:P28222"}
{"id":"ac2bc000-b3c1-4e67-8ee9-506e59cfbf52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9844711","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:b195410a-6a7f-4503-830c-1f29f06ee388","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:746","original_object":"UniProtKB:P23415"}
{"id":"f11f6e4c-1091-466d-8332-99a6e86a4e37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1106","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:68ad94fa-ef1f-41fb-8545-d486ddec3a18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1106","original_object":"UniProtKB:Q02644"}
{"id":"2bcc85d1-e478-456d-8d39-8b034e2de6df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63622","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:ddc04a64-662c-4523-ab18-dc2ba19d4f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7297","original_object":"UniProtKB:P07550"}
{"id":"557093b4-22d8-4762-a2da-57a4e7dffde2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8058","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:8086f8b3-812b-4b4c-96d2-f222c60bdf54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4282","original_object":"UniProtKB:Q12879"}
{"id":"2f150bb7-3e65-4dd8-8281-ea420107197a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10001434","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:79e1192f-ea68-4693-b2f3-0f32ebacda6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4326","original_object":"UniProtKB:P34903"}
{"id":"f2c40e79-e31c-4fab-b949-0fce867fa970","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46866109","predicate":"biolink:affects","object":"NCBIGene:18216","sources":[{"id":"urn:uuid:557f2306-0598-4a55-b445-7464511087a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5308","original_object":"UniProtKB:O88319"}
{"id":"04043fb9-e374-486a-be6d-9033364ef8b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G0G0H52U6K","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:17b38dbb-f75d-407c-9f88-7ee39cc34fcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10315","original_object":"UniProtKB:P43116"}
{"id":"8ee5256e-09e6-41e7-8c94-54d7d57b5089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:123188","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:2a5eb6f4-3e09-413b-aad0-4007b9864a4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10288","original_object":"UniProtKB:Q9UBN4"}
{"id":"bb0bb57b-bd08-48fa-b996-6ab312cfcd19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:443398e4-d063-431f-872e-1ba1d0ac2c2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:P22002"}
{"id":"dcea85bd-0a57-4439-a428-7c5544eae8d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4468","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:32a1b90a-a546-4897-b299-8487c7c072e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11230","original_object":"UniProtKB:P51575"}
{"id":"9d98f9cc-de6a-4450-8f88-cad56172240b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136197286","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:4b51b142-4038-4cb2-91d8-877d16fb8770","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12781","original_object":"UniProtKB:O76074"}
{"id":"fe37c2b3-e82b-46db-9c20-e6421f0bc48b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311040","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:a419a0a0-a279-464c-aefa-0dc0b2469023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3421","original_object":"UniProtKB:P23385"}
{"id":"204333c5-902f-4f36-a930-e5ecde314da3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:05530552-9d3f-47ae-b36f-9e0451b2c70b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:Q62053"}
{"id":"1ac4198d-1ae8-4a78-bc57-2bd9298127b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1P43YY1KO2","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:2833117e-2cd5-4861-b012-b77b92cde011","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12429","original_object":"UniProtKB:Q9NYW2"}
{"id":"98020cf3-be0e-4218-aeb9-306e353df6c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:037V4520IY","predicate":"biolink:affects","object":"NCBIGene:191","sources":[{"id":"urn:uuid:16a6ed4a-4fc0-414c-b1d6-8320689a538a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5115","original_object":"UniProtKB:P23526"}
{"id":"3f4c6ee9-52dc-471f-a640-0bd5c066bdd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21779964","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:3af461a1-9c29-48d0-b821-4eba4471799f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1604","original_object":"UniProtKB:P41143"}
{"id":"8e080314-a062-4b5d-a767-a2fd135ab2cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194402","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:f070f28b-b2e3-468a-8c44-46269b36013c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2199","original_object":"UniProtKB:P37288"}
{"id":"6e35f603-3bb8-40ac-bff3-92dd81656f54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52670832","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:eec4ce43-5810-4936-a7da-306f3cb9c374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7524","original_object":"UniProtKB:O60885"}
{"id":"8acf63c1-53a9-4f86-8260-de8cee723a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:4eda8b0e-cb30-4c56-86be-e2f81350e876","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:P04049"}
{"id":"25150432-9827-4fd3-8b32-f78aef1090fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17134","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:f005c8c9-9eb8-476b-8083-553d5863bea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2149","original_object":"UniProtKB:Q923Y8"}
{"id":"03752d77-9c48-494d-a0ba-15ca366c0609","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9824353","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:cf3c0591-4eb6-4d97-9b7a-397c15443a31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8541","original_object":"UniProtKB:P32240"}
{"id":"1646b9fb-b6be-4bd0-a23e-84f93752f523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:644212","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:92cefcd5-dd23-43ed-bfb1-ff73ceda2bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1344","original_object":"UniProtKB:P49286"}
{"id":"fba6d401-2c73-4dec-8f35-743ac6f765dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:54704e05-c469-4c9e-aef5-970db783c195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P30939"}
{"id":"029c764f-d634-4a58-acff-2d26eb349499","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:19511","predicate":"biolink:affects","object":"NCBIGene:2846","sources":[{"id":"urn:uuid:a2d9b418-1de3-4e1d-99e0-f7a8751910d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2910","original_object":"UniProtKB:Q99677"}
{"id":"3b9b2ed4-820f-4f0e-b3f4-448801b8ec3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448902","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:b7d464b4-a432-4903-8973-2e405f8a0d45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12485","original_object":"UniProtKB:P11362"}
{"id":"025e8820-faee-4775-bd94-d6e7db97c34d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4754","predicate":"biolink:affects","object":"NCBIGene:1582","sources":[{"id":"urn:uuid:0415ec5b-ec6b-4450-a13c-61cd28dfbddb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2446","original_object":"UniProtKB:Q9UNU6"}
{"id":"5eebd797-4ba4-49af-bdbd-c772f3d42c53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4206177","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:9a4c7635-9ffc-4c51-a223-6f77f1ec4e96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3515","original_object":"UniProtKB:P47871"}
{"id":"518bf784-7c9c-4524-b362-9e79ed5a876a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86721856","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:6f709a88-f660-4b33-9708-36f76f28b1c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11983","original_object":"UniProtKB:Q06187"}
{"id":"b2158215-cdfb-43bf-8621-85bbe7845127","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139269773","predicate":"biolink:affects","object":"NCBIGene:5551","sources":[{"id":"urn:uuid:21702519-bad7-4689-b115-ac5087522667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10501","original_object":"UniProtKB:P14222"}
{"id":"5e878b6c-4152-428f-9327-c866b2da466a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11080","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:04b4097a-7496-4414-9ac9-807012b2edeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11080","original_object":"UniProtKB:O94759"}
{"id":"0b60d5d4-f935-4f36-9b8e-f9a8527015f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:2f0c3778-d0a4-4cea-992d-e5a53dc0ac7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:P29597"}
{"id":"4b1293f1-4a86-48f2-9baa-bb5445700247","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3761","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:cd18c060-878c-4263-8784-79fbfebcef69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3761","original_object":"UniProtKB:P35414"}
{"id":"0e2cfaf9-1c86-4ce3-8198-0eea3b222eb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9860053","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:99021531-3924-4bf4-af91-568d2b159748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1261","original_object":"UniProtKB:Q9Y5N1"}
{"id":"8ede60be-b60d-4ba4-9a65-d543b7ba30fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138624627","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:e6d4f126-d48a-43cf-9164-659067cf4445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12871","original_object":"UniProtKB:P23458"}
{"id":"0d002491-e0a9-473f-874f-95cdd492704c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5558","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:f2ff71b4-75ea-4325-8d31-2b6f98406e41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:522","original_object":"UniProtKB:P18825"}
{"id":"d819c5b6-f4c6-4a8d-92ec-9edc29483dfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5441","predicate":"biolink:affects","object":"NCBIGene:11309","sources":[{"id":"urn:uuid:45ee698a-9de6-4c6b-bb51-bd3b18ce6d32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2414","original_object":"UniProtKB:O94956"}
{"id":"0076d614-775e-41c5-8711-f0db0c3d1c38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11475","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:ff8709ae-65d4-4d87-a5f2-7f874221984c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11475","original_object":"UniProtKB:Q9UHC3"}
{"id":"912cb437-f3be-49c0-87c8-a1b100ec079d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71681016","predicate":"biolink:affects","object":"NCBIGene:354","sources":[{"id":"urn:uuid:4dd7cb2d-14b6-4c99-ad53-db9008853368","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8486","original_object":"UniProtKB:P07288"}
{"id":"84f4ba5f-f591-4487-a710-a832b2cbeeea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:2a4b80de-29bc-48cd-a22e-3382ee7fa49f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q9WTR1"}
{"id":"574e9956-170c-4783-955a-0f56a8807e5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:30902d5e-d220-40ab-9dbb-b148db9f63d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:P41595"}
{"id":"6aa1699c-a53d-4474-b0d1-942c5052e56e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PUY08529FK","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:fa467e9a-c629-4ad5-8ef7-8a4716b695d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8413","original_object":"UniProtKB:Q14524"}
{"id":"7f593d0c-160e-44e6-81b4-b9e061ac6fa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T989JBG788","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:b4446a2e-6dd9-446b-8e8c-03fd98158a44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10376","original_object":"UniProtKB:P34998"}
{"id":"ca015f7a-d01d-435a-9d09-8b92de8ccefc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7761","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:8871abb1-661c-454f-8f54-e5ba9e87f387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7761","original_object":"UniProtKB:P15387"}
{"id":"2f539b5e-3562-4a2d-8b21-06ef685a07bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2701","sources":[{"id":"urn:uuid:2d2f9f97-a22e-4f38-91df-b4d0e21aea94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P35212"}
{"id":"9b92dd04-6d14-453f-907c-d1eb5999236d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:718a40d7-8bbe-424e-989c-d82f62e068db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:A8MPY1"}
{"id":"0c27dd7d-a9b7-4ae6-80cc-d0d2503e6ce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2565","predicate":"biolink:affects","object":"UniProtKB:P17659","sources":[{"id":"urn:uuid:c13f841a-b951-4f8d-ab5a-d74970136d8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2565","original_object":"UniProtKB:P17659"}
{"id":"83519f57-7094-4818-b3d6-8dd0ea5addb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172325","predicate":"biolink:affects","object":"NCBIGene:56339","sources":[{"id":"urn:uuid:e97678ac-2fa3-4833-abfe-9957073b9567","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11529","original_object":"UniProtKB:Q86U44"}
{"id":"148427cf-ba07-43a4-9b88-c4a6b3e3b303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311009","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:912c8f0d-6bf8-4b74-8cb0-b82a40ebb8b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3384","original_object":"UniProtKB:Q9H244"}
{"id":"6a513180-795b-4dec-aa30-7b5569a0f93c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1168","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:b3ca5731-af1b-4fc7-8179-2a36ec063151","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1168","original_object":"UniProtKB:P30969"}
{"id":"67ad8ebb-87a0-43c8-a4b1-40058a3c4354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34965","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:0afb3ec1-708f-46c8-b05c-89bf78aa2af2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2562","original_object":"UniProtKB:P22460"}
{"id":"865ccdbc-f928-4908-a369-9ff822f59225","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L9790S42AI","predicate":"biolink:affects","object":"NCBIGene:10892","sources":[{"id":"urn:uuid:18b9071b-ee17-4c90-85a7-32c1c720026a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11883","original_object":"UniProtKB:Q9UDY8"}
{"id":"30fe3449-f2e8-4362-8c8d-591682702b22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:2b6febef-6395-4401-9db5-e9f0e26429a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2330","original_object":"UniProtKB:Q7Z2W7"}
{"id":"c0d357d6-49bb-4f75-b675-49bef8d27eef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1524","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:7b98ee35-a5e0-4502-b327-fe037df83be4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1524","original_object":"UniProtKB:P21555"}
{"id":"6c35e6f2-84c4-4505-b413-f286a32ee887","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:811","predicate":"biolink:affects","object":"NCBIGene:1236","sources":[{"id":"urn:uuid:567d86f5-fede-4d3d-85e7-8b5ebc73a577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:811","original_object":"UniProtKB:P32248"}
{"id":"02655ffa-1743-410e-803f-8863324f1c11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:a1a7c455-27d0-4399-93ee-350e99725cc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P34995"}
{"id":"cc86968d-e815-4e3d-a644-f8a410d63fa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:164890","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:f009a918-2107-4e27-9ea6-c2ad4213b37c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12424","original_object":"UniProtKB:P59534"}
{"id":"163c7a70-de72-49dd-a036-fbd592446e7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75722","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:c71aff29-9727-4a34-90b7-d7f4884ef7e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8286","original_object":"UniProtKB:P41145"}
{"id":"94802790-15e4-490d-9629-c0f01e0acd5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699437","predicate":"biolink:affects","object":"NCBIGene:1445","sources":[{"id":"urn:uuid:3bfe572d-6fc6-42c0-b674-22d33467dd07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7648","original_object":"UniProtKB:P41240"}
{"id":"758b845b-9d31-43a7-aae7-4346ceccce38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5RV7T5BNMG","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:2629309b-1e59-4a14-9a04-ce63815a06ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8984","original_object":"UniProtKB:P25021"}
{"id":"b7825964-6914-484b-afb8-aaa7a200f030","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135809","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:6d98684f-8c53-4363-be82-c4bce0cda301","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13192","original_object":"UniProtKB:P08588"}
{"id":"acf9d8b2-5ef8-458e-a6aa-b2cab22fed42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7465","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:0cf57edd-8e77-4fc6-bf3f-91248ceb60ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1639","original_object":"UniProtKB:P41143"}
{"id":"e58e790f-57f2-4cd0-998e-f658fb65e919","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679305","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:b9d99929-908f-4f90-b5a0-51487a39549a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11906","original_object":"UniProtKB:Q8TDU9"}
{"id":"e3be9822-bf44-4070-a21f-f7b049f57309","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5487427","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:841945da-5aa5-46c9-826a-9488f77dac12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8592","original_object":"UniProtKB:P20309"}
{"id":"861e8a8c-5232-4454-83a4-ffd600aefa1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92624","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:f984696f-5191-4f44-9769-9833a644c033","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:890","original_object":"UniProtKB:P30551"}
{"id":"9a561081-8679-4153-ac5d-4876cb422f3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2KCV39GKGL","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:2df4a407-0f28-4873-a23f-f966460485c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:445","original_object":"UniProtKB:P29275"}
{"id":"00e5723a-ca04-4781-aea1-24cb806fb30d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92744","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:d15b3f9f-251f-497f-a4f7-0d99f0248b3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4669","original_object":"UniProtKB:P30531"}
{"id":"47b23e80-ac00-48a9-9550-1248e8cf5a70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1505","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:2ac9f87b-8cba-44ed-9369-5682816978e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1505","original_object":"UniProtKB:P25929"}
{"id":"bd69f9d1-9ce7-4f4c-800d-7013b8b54725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:29465","sources":[{"id":"urn:uuid:1bd4b5f3-5fe2-4e5d-b229-17bedf4b964d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:Q9WUD2"}
{"id":"1a2cca6c-7442-494f-bebf-eb5a377f6f35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34967","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:f6ecd077-443a-465b-9bc9-9b5e9a01fccc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:743","original_object":"UniProtKB:Q9Y2T6"}
{"id":"71431c44-46d6-430e-a3d9-b738139e38f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:f4fa4c8e-1dc0-49ea-b9a8-a1b5244b3b19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P34980"}
{"id":"19e7bab4-bfeb-4a8f-aa2f-d7fc27b01abe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:fcaf1155-f1ae-47ab-8626-73002932f263","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:P49841"}
{"id":"a3e5b333-9668-49a4-a922-06474a9e1f4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2256","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:7923130a-a898-4d1e-bc66-8742048f6c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2256","original_object":"UniProtKB:P30559"}
{"id":"da45ca0d-d4d3-47c3-a567-284e01aa20ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3SY30OEV1U","predicate":"biolink:affects","object":"NCBIGene:1889","sources":[{"id":"urn:uuid:86b5319e-6f8f-4542-b510-579c533a4ef5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8617","original_object":"UniProtKB:P42892"}
{"id":"d4baa7bd-05ca-45ba-9392-4d43ed2b34af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131686","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:0d6b600b-20b5-40dd-a0ab-f87552ca40bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4153","original_object":"UniProtKB:P13569"}
{"id":"c0ccff95-a307-4e27-86df-fc6b9228df7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134991","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:595cda97-80b8-4fc6-9380-b5acebd38d1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7191","original_object":"UniProtKB:P28222"}
{"id":"37c53bb4-c9ad-4985-9b87-63a9650a7739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1795","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:897890aa-05ef-4b38-b861-1e60b4eb6776","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1795","original_object":"UniProtKB:P25961"}
{"id":"1bafbcb8-6a64-4e5b-bf7e-f206f67288d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9829836","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:32001366-cb44-47ec-88c9-a68f3d5632ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3931","original_object":"UniProtKB:P13945"}
{"id":"8a0c35a7-b882-4ca7-a7e7-3ddb6da62c22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:329954","sources":[{"id":"urn:uuid:6fb577dd-3c52-4838-abb8-2fb85743c437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q8BVN3"}
{"id":"0a2f7cd7-52cf-4d6d-8741-755d533039a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4135","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:2a89e23d-f435-4d90-be8d-82a7b8db2636","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4135","original_object":"UniProtKB:Q9UHC3"}
{"id":"3b5301f3-c51f-4c84-a62d-4a95e9609690","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:3768","sources":[{"id":"urn:uuid:f2ddf46f-a5b7-48b7-b159-bc12fd8661d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q14500"}
{"id":"e86fadaf-ebcc-4f6e-8152-1be4c1d44b74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:805471b1-dda2-4f98-8582-725f4f3bf7de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P41586"}
{"id":"cb8b86db-bfc1-490b-9452-397d5fa193cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:6ce70d41-1d3f-4518-8547-0e30313b018e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:P06239"}
{"id":"a3f2613e-5e26-42dd-8251-83bfa03c86e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92341","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:768b2658-7ba8-4d20-8233-92b028243d26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:15","original_object":"UniProtKB:P28221"}
{"id":"53328e30-651d-4442-81c9-eaa7f2df9946","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232894","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:b34e0060-8d92-47b6-92db-117552ab5279","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6386","original_object":"UniProtKB:Q8TDD5"}
{"id":"34b89191-0c7d-4277-9c6f-0e7eff3ff52f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:a847d7ef-4cf2-40a3-aa9b-7d9eb3f31833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P24046"}
{"id":"f57a8797-2d73-4013-94c9-5d0618deb421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59773","predicate":"biolink:affects","object":"NCBIGene:259295","sources":[{"id":"urn:uuid:fb306c1f-b699-4e7e-99f1-644423d18110","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7608","original_object":"UniProtKB:P59543"}
{"id":"5eee6602-7c99-44ed-9f00-4c3e46cfaa3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:171166","sources":[{"id":"urn:uuid:64728309-b25e-4454-93a4-abaf93854e86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q8R4F0"}
{"id":"583ab561-7861-490c-b9a9-caa0613420b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2264","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:6de789da-7e4a-47a1-91df-5dbab25e2869","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2264","original_object":"UniProtKB:P41586"}
{"id":"9ab091d1-379e-4a4e-a8d3-51d687633f02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8988","predicate":"biolink:affects","object":"NCBIGene:24267","sources":[{"id":"urn:uuid:74821856-eb2f-4eb1-b928-6248cf215b9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8988","original_object":"UniProtKB:P22734"}
{"id":"e3929774-69aa-46da-b08d-492a9a7fe73d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232894","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:f3129d5e-067e-4456-9673-a5f253c8b83b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6386","original_object":"UniProtKB:Q9GZU1"}
{"id":"8a077d69-4da4-43f9-8707-13e0b42bb375","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:88128ebb-f38e-4e4a-af54-c31258c00a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:Q14330"}
{"id":"444830d5-7069-467b-9cd9-bd2e26895d71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2381342","predicate":"biolink:affects","object":"NCBIGene:5607","sources":[{"id":"urn:uuid:d936dc53-ff30-47de-a310-e99ebb0670e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9380","original_object":"UniProtKB:Q13163"}
{"id":"4df001ba-9f9c-41c2-af8e-e4d4adfaae35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36773","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:ff1d3dff-468f-4444-8d46-e8743897651f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2422","original_object":"UniProtKB:Q8K424"}
{"id":"711a9085-da44-4d8a-b725-d4abaaa14b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072557","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:7ec5b3fd-ba80-493a-acd0-1d137c2d85d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9000","original_object":"UniProtKB:O00519"}
{"id":"e831b56d-a7ed-442d-810a-37f3045c1cfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081957","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:a4d802f5-8b58-401d-957a-99164727d87d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9837","original_object":"UniProtKB:P42345"}
{"id":"9ce45915-692f-495e-a466-61dc8439743f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5959","predicate":"biolink:affects","object":"NCBIGene:6554","sources":[{"id":"urn:uuid:28f8ca36-901e-4f9a-96e3-ea3215267460","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:589","original_object":"UniProtKB:Q14973"}
{"id":"0c50b913-3107-4b4d-aa20-c7519e87b000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177770","predicate":"biolink:affects","object":"NCBIGene:3320","sources":[{"id":"urn:uuid:08b5d2bd-59d0-48ca-9cab-c3c483f48a78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13309","original_object":"UniProtKB:P07900"}
{"id":"e830df06-fe5d-4814-80fa-d8156b334053","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4893","predicate":"biolink:affects","object":"NCBIGene:5618","sources":[{"id":"urn:uuid:77db76f3-25fc-4fcb-ab5b-fdd197c09c73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4893","original_object":"UniProtKB:P16471"}
{"id":"e890a279-c9e2-4f00-8ff0-318d664c00cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2258","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:2fa40682-56f1-4c58-a88b-240e4aa748ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2258","original_object":"UniProtKB:P32215"}
{"id":"f731b236-b77a-4183-9381-3b7717a7c3dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9936595","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:cfd0d1a6-f700-4199-9dff-d8a7b740303d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1921","original_object":"UniProtKB:P34980"}
{"id":"8c46fdb5-fba0-4da6-a9ef-5f2403740ed2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4749646","predicate":"biolink:affects","object":"NCBIGene:11213","sources":[{"id":"urn:uuid:91fa3df3-b47d-4119-a4ee-2c56e13956b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11785","original_object":"UniProtKB:Q9Y616"}
{"id":"41f16cf1-24d4-4f9d-9b10-45394c891c34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16842","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:662631c7-8152-42af-bdfe-15cf6ae88397","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4196","original_object":"UniProtKB:Q8BLA8"}
{"id":"1dd03c6e-3c3e-4b94-9d9e-6d73f8e793dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88339","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:310dbf2a-2ea9-427d-b465-7ba3f0b227a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7952","original_object":"UniProtKB:P08069"}
{"id":"09dc9086-8095-4a72-8f2a-c7ec541abd76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:9c8a1704-3606-41da-a030-fb46fd2e38c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:P21554"}
{"id":"91c2f4c8-4490-49d6-92ea-45a3df099018","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:100126572","sources":[{"id":"urn:uuid:7db83661-b296-4bcb-8ef2-f8826fa2d20f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:A6NN92"}
{"id":"96177a5f-c3d6-41f3-abb5-90d2523ce189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6278000","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:9c449814-5de4-46d1-96fc-e31a3e33fbf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1382","original_object":"UniProtKB:P23385"}
{"id":"6120e4a0-9057-45ba-bb64-bfdd708d4b11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134828250","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:f7040283-0e18-4b3f-8696-3a9255782ecd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8523","original_object":"UniProtKB:P35414"}
{"id":"1fee44df-a7b7-4a20-94a8-b7d222198e5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XS8JT2C7RL","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:fb025c64-ef6c-45be-b014-2f8cc0e87cc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10110","original_object":"UniProtKB:P43116"}
{"id":"91a23485-93cd-4e15-bdcb-aca6342be9a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77961","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:f9785d0a-5578-4d95-a6e4-53cb441bb7d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2916","original_object":"UniProtKB:Q9UBY5"}
{"id":"7d9f44bd-d916-492c-9a92-1e9c230825d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2821638","predicate":"biolink:affects","object":"NCBIGene:339983","sources":[{"id":"urn:uuid:9e051f37-f3eb-401f-b37a-4eb4675704da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11155","original_object":"UniProtKB:Q8N9F0"}
{"id":"a35fda72-ba7f-4a9b-9590-a4cd67f54022","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2270","predicate":"biolink:affects","object":"NCBIGene:2692","sources":[{"id":"urn:uuid:3e2e817c-a50a-49db-8415-38ca1c7e51c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2270","original_object":"UniProtKB:Q02643"}
{"id":"68ae9b02-129d-45a4-ab82-6a8ea7c1fe05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6115","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:4c225e88-6df3-40b2-88b5-34ae1d15a87a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6115","original_object":"UniProtKB:P47211"}
{"id":"87767d13-cce7-4aa7-a651-dd5d33c41d6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8932","predicate":"biolink:affects","object":"NCBIGene:10507","sources":[{"id":"urn:uuid:33117218-51af-4a06-aa34-4d5672044c87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8932","original_object":"UniProtKB:Q92854"}
{"id":"b645d0ed-23af-4021-812f-691bd852729e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:25CG88L0BB","predicate":"biolink:affects","object":"NCBIGene:13032","sources":[{"id":"urn:uuid:a3fd488c-193d-4ec9-a2e5-b8c595c8d42a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9412","original_object":"UniProtKB:P97821"}
{"id":"9b379dec-0d1e-4535-8d4f-ad12e3d8de6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92275","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:47c0bc56-93a4-499d-8825-24b119822b87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1597","original_object":"UniProtKB:P49019"}
{"id":"79bf6a02-5800-4487-a24d-a16e1d3b1fde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1V3OH20HG","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:f2c40c69-ed0c-48b7-b597-08907049b805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10504","original_object":"UniProtKB:Q99572"}
{"id":"6f679bf7-c56a-4721-ac5b-f1700304d531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143992","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:303c20be-b1de-4c50-a0c5-1152f69b61c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1410","original_object":"UniProtKB:O15303"}
{"id":"2a2331e3-aefb-4695-9504-d208583a552c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:c462aa26-3e5d-4280-ac65-7342e1256c19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P28566"}
{"id":"0476e2b4-aeae-4638-847a-d9458498896b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:836","predicate":"biolink:affects","object":"NCBIGene:57007","sources":[{"id":"urn:uuid:f98c5502-40e5-4e99-a778-5f30c6f68008","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:836","original_object":"UniProtKB:P25106"}
{"id":"ca9131f3-acf5-445d-b9e1-a6d619826416","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699463","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:965e4cce-1f9c-499c-8ad4-f16ebf22f9dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11220","original_object":"UniProtKB:O15379"}
{"id":"d92ade40-94c3-49e5-83c3-3bcea1dd78e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10338547","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:6dce3ebc-03b7-418f-9643-f06f60f21634","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6204","original_object":"UniProtKB:P23385"}
{"id":"ad917767-d3ce-4920-aada-debfd6b4b8c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9843206","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:36676f27-3a42-422b-a01b-574d967e344f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5964","original_object":"UniProtKB:P04626"}
{"id":"2eceb4ea-3f7d-43ab-8980-93fb42845377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:ed91d265-e7a3-4780-9f2d-629b31e21b7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P31388"}
{"id":"67e058d1-696b-4ba0-b41d-675a68f4792f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11286","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:a2aa632a-dbd0-4a17-9702-560a75de2016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11286","original_object":"UniProtKB:Q16581"}
{"id":"014d550b-5a1e-4c87-964b-d7434013b603","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:10052","sources":[{"id":"urn:uuid:402eafb4-5ca5-40da-95c0-73d2713106f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P36383"}
{"id":"9fe93371-6dfb-4b7c-9865-8a139cd09a1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3738","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:4c4cbd73-b031-40db-b03f-929f31522948","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6063","original_object":"UniProtKB:Q99572"}
{"id":"21e20dcd-e7da-46c1-84b7-4746f62bcc40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311026","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:28090882-8a66-4bb0-9a0a-fe001a7b81d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2083","original_object":"UniProtKB:P35346"}
{"id":"f9bfb07e-78b4-459e-8ce4-03bdd5001823","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9553","predicate":"biolink:affects","object":"NCBIGene:81574","sources":[{"id":"urn:uuid:c501227d-921d-47bb-a3c4-1db09f1449b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9553","original_object":"UniProtKB:P04774"}
{"id":"b40f5879-7c10-481c-86aa-88a1c3e3c9e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0T4IMT8S5Z","predicate":"biolink:affects","object":"NCBIGene:3417","sources":[{"id":"urn:uuid:c42e7e05-fb2f-4aec-a997-92664bd6f0c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10319","original_object":"UniProtKB:O75874"}
{"id":"b9101c99-392c-4f10-8eea-631da1d6adf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13819","predicate":"biolink:affects","object":"UniProtKB:O60449","sources":[{"id":"urn:uuid:d9065d6c-3c0e-4d5a-b035-4342b05e40ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13819","original_object":"UniProtKB:O60449"}
{"id":"45648aef-6d70-4be2-aaf7-4f569295860d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:5203cfb6-1715-489b-9cbc-30ddb4ee15c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q13547"}
{"id":"56781226-41b7-4f59-898f-1f0699536688","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:817","predicate":"biolink:affects","object":"NCBIGene:10803","sources":[{"id":"urn:uuid:a6f5db7c-917a-4607-8408-62feb47c95ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:817","original_object":"UniProtKB:P51686"}
{"id":"ec788592-eb09-4a9c-8c76-0c2655f5e532","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85980","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:4e9fb085-2079-4c7e-8353-9194c490003d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7691","original_object":"UniProtKB:P33535"}
{"id":"91c5dbbe-e851-48bd-8b24-ab6c59ae2c73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136040","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:b5be5f37-f6ec-4129-8976-54a13c685949","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7435","original_object":"UniProtKB:P23975"}
{"id":"70671b75-f43f-42fe-afc0-aab0ea73ac75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31832","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:6774bec4-864c-4871-acb3-71918460d656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2431","original_object":"UniProtKB:Q8BLA8"}
{"id":"0d618277-7238-4e43-a11e-43d37d8485ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22960366","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:092845ad-5845-4c3b-8ed9-3687e9432d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1750","original_object":"UniProtKB:Q15077"}
{"id":"bdbdea1d-b4b3-4286-8719-af1d03ad53c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K41YC3AEI8","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:7bc4d078-c0b3-4e78-81e9-bd0ddb6b99a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1622","original_object":"UniProtKB:P41143"}
{"id":"8e6aa546-fbd9-4228-8212-72faf6346eaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135348858","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:5b3581c3-01ec-48ef-bceb-1460a75b30c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10490","original_object":"UniProtKB:Q9UBN7"}
{"id":"aaa49bec-aea8-487e-b855-db89aef7d9ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2039","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:12826381-c03c-42eb-8485-3d21412a5e05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2039","original_object":"UniProtKB:P30935"}
{"id":"96dab812-b66b-4a4b-bb85-5c6e1b5ffc23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:919","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:2b65893d-f880-40c0-91be-165f4c434ba5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:919","original_object":"UniProtKB:P34998"}
{"id":"cc412c78-dfea-45aa-97f7-991c456a02a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8378","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:f7da0881-a516-4c40-975e-b5b89604a96e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2866","original_object":"UniProtKB:P08235"}
{"id":"f1730337-c01d-43db-9024-7ce615e8048b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:16508","sources":[{"id":"urn:uuid:c4fb4e59-9097-4986-81cf-214756c57a3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q9Z0V2"}
{"id":"8ddbeeee-afc7-4212-bf88-55a8feea2852","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:be11b26d-1e59-45be-841a-c28a0f80406b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P08908"}
{"id":"5d9254df-9b65-4ffb-bd09-4972a47899dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47781","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:bea9e3ed-ef58-4839-89de-22a017b9616c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2399","original_object":"UniProtKB:P48542"}
{"id":"702aabf4-7487-45e1-8448-574581852c00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:3066e42c-9e95-43b6-91b2-2e3eec489276","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:P80192"}
{"id":"6fed07b2-75a9-4e77-b64f-4b7a3e33565e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JTZ51LIXN4","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:c284b0f5-6e6d-4c46-83a8-842a5ada9c83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11413","original_object":"UniProtKB:P51813"}
{"id":"7c318f79-61d6-412f-aea4-da790de22ba9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95170","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:5ab74225-342b-498f-8207-5255ca332e86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:351","original_object":"UniProtKB:P10980"}
{"id":"7c4e413f-df86-4e40-bb6b-5e923da42025","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94777","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:5d160d35-3edc-45f1-b290-f58e50758a9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7556","original_object":"UniProtKB:P35462"}
{"id":"f9962568-5240-481b-bc78-ec7e0b15bd17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156273389","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:88128e6d-9e2c-4897-b1f6-b83cb00bc09b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12313","original_object":"UniProtKB:P22455"}
{"id":"5224690a-b00f-44a0-abcd-6a3b9e3f37a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1320","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:ad3f333b-af97-4c90-8c44-a3711bf35e76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1320","original_object":"UniProtKB:P41968"}
{"id":"26696a1f-ff40-4500-98e9-211b4a84b35c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755171","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:062e3252-037f-49b3-b6ef-fc328389ab9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6069","original_object":"UniProtKB:P21731"}
{"id":"1b8b23f2-8011-41ac-b071-3acf802c5696","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67979346","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:5bb91211-c849-4912-877b-50b501278959","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7789","original_object":"UniProtKB:P56817"}
{"id":"bb46d8bb-0867-4fc8-8733-d69d54598ea4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R0GPP0WDF9","predicate":"biolink:affects","object":"NCBIGene:12802","sources":[{"id":"urn:uuid:ea33681a-7d83-499f-9fd7-882eec35975b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10202","original_object":"UniProtKB:P47936"}
{"id":"9cc71f55-1abe-44d4-98e9-4bcc5c068e40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310996","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:eda393a3-7dc3-43d9-b871-5a6ee829797a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1755","original_object":"UniProtKB:Q96G91"}
{"id":"98cf5299-8e65-444d-ae49-08aa21a96c4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27566","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:b85040d8-7d95-489b-9e46-00f867eb7b97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12585","original_object":"UniProtKB:O43497"}
{"id":"1ff583e8-18b5-40ef-93f2-bec6fec0fafd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233306","predicate":"biolink:affects","object":"NCBIGene:6446","sources":[{"id":"urn:uuid:1819acd8-bb26-4d33-acde-c6e0abff4ee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13067","original_object":"UniProtKB:O00141"}
{"id":"cb1e8f59-95be-4426-ba0c-960cb457a3d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:3f0bc361-0d74-4deb-a4f6-416ac482d49b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q9H1C0"}
{"id":"85b16e19-17e8-4822-81d0-b101fab86bd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109545","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:fce1a4f1-d430-4d02-9280-80d64f79de37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1346","original_object":"UniProtKB:P48039"}
{"id":"df365505-28cc-4b1f-8f6a-0c2d7553d7e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71662429","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:8be8ce34-ea5f-49c3-b1f2-faed5ce632f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8748","original_object":"UniProtKB:Q16678"}
{"id":"485b4171-2dc6-4f32-8aa1-1af770a972f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146025595","predicate":"biolink:affects","object":"NCBIGene:6768","sources":[{"id":"urn:uuid:350de50f-697a-4f64-a3d0-31deaf10337e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10733","original_object":"UniProtKB:Q9Y5Y6"}
{"id":"f123f103-441c-4616-be51-83ff1ca2746b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124921","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:668bc0bd-a3cf-4a42-8ee0-404c51fb864b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7012","original_object":"UniProtKB:Q15910"}
{"id":"d8874c29-15d3-4e1c-97e7-9407c255c0da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6QVL057INT","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:cd02b4ef-7ba4-44f5-ac39-68650d02450b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10090","original_object":"UniProtKB:Q15116"}
{"id":"d38736af-bf6c-46f0-8865-8a97db8e96a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:8016395","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:28b21ae2-1e23-4b15-a1c5-5228c9670548","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12974","original_object":"UniProtKB:P49760"}
{"id":"03d3851f-63ee-4361-a35d-5cd5551a79b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3187704","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:43ddea61-cbc9-4fc1-a944-0fee13d1f23d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5518","original_object":"UniProtKB:Q13304"}
{"id":"cc4a81ae-1252-4773-b14c-6d9718323f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172701","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:ba1ff244-bda9-4d1b-a9f2-1761a762326b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1709","original_object":"UniProtKB:P47900"}
{"id":"cf5a5074-9481-4f43-9e08-129a3e1b877e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45307","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:ceb178f1-4e97-4bc8-b5ea-6064b3a44551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6035","original_object":"UniProtKB:P50750"}
{"id":"974491d3-717c-4f54-93a6-f5194deb3cb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:671","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:275f033e-33e4-4755-b497-d76b813a1c28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:671","original_object":"UniProtKB:P30411"}
{"id":"33f77873-25c5-421f-b242-3d8546829869","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135524168","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:58bd75ee-fe41-41a4-a10d-9b719c88fe73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8178","original_object":"UniProtKB:P08581"}
{"id":"ab9374ad-6085-416b-8197-d3099e97adf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9873836","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:c32a79e6-d214-42ea-a6e9-d919d1821345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:885","original_object":"UniProtKB:P30553"}
{"id":"3751cf5f-41e1-46d9-9aa8-dd35f0065e45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135654","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:9ffa747f-4202-4da5-b360-f43a30ee06b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6377","original_object":"UniProtKB:P12821"}
{"id":"e0adc329-e942-48d6-be9b-c86e946f0712","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4854","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:8acc37d8-be17-4681-a615-ed2b06bf2f22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4854","original_object":"UniProtKB:P25092"}
{"id":"42d7c4ff-bd64-4bf0-bcb4-bf609e52e948","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42724","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:ff7aad6a-fe09-4f9a-bd19-b5eff23da5f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2146","original_object":"UniProtKB:Q96RJ0"}
{"id":"088fd04c-abe9-47a4-b0bf-a33a38c4fbb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3710","sources":[{"id":"urn:uuid:7f17de8c-9f8b-4b14-9a7c-227c78f522bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q14573"}
{"id":"ac571d26-37ce-41be-bede-641843060d17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177430","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:d51b44d7-79e1-4a68-a193-1a6f8ed6f56b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10180","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"046474e3-89ef-4a05-b382-176eb3c000d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7494","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:07b39895-7b8a-42f5-9a1a-683db26005b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7247","original_object":"UniProtKB:P23975"}
{"id":"e2472218-6ee1-4130-9928-533d1b3923b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2F16KW647L","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:5101671b-d404-4beb-aa8f-5663cba227a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9203","original_object":"UniProtKB:Q16539"}
{"id":"7772a8fa-edd3-4e56-b41d-d64d8ca87528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118965258","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:bac09358-29ee-49f3-a72a-bac36995a972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9701","original_object":"UniProtKB:P61073"}
{"id":"3de0d0b8-378c-47fb-bd94-a103c54310ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44256277","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:89432d05-3247-4a81-9ff1-c142c1c6d391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8143","original_object":"UniProtKB:P08581"}
{"id":"62c1ed8c-b51a-47b9-9b54-fd09dde529d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76317442","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:7bd7e5ca-f973-44b4-872f-a03358ba8a73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8824","original_object":"UniProtKB:Q92793"}
{"id":"4f8677ce-aeec-4e33-8821-b10b87e2b121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:53104d9d-8fa7-4001-a5d3-2d326fe14c4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q9UQL6"}
{"id":"fb91e43a-af2c-433d-8bf9-c3927428c277","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129606875","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:a141df33-3d9a-4099-aebd-0b6065ff6725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10626","original_object":"UniProtKB:Q9P1W9"}
{"id":"e53b9139-ea19-4588-8a23-104f690e5276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12420","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:b273797e-5ee8-4957-882a-62079607923c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12420","original_object":"UniProtKB:Q96P65"}
{"id":"6ca812d2-d980-49bc-a19d-d969e8eba217","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8736","predicate":"biolink:affects","object":"NCBIGene:6554","sources":[{"id":"urn:uuid:a2e444eb-ec75-4a2a-adfd-4dd39d5ce141","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7596","original_object":"UniProtKB:Q14973"}
{"id":"e6cf5fcb-fcab-449b-babb-9a207e2809ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:25689","sources":[{"id":"urn:uuid:76555e52-f6a0-46fe-b49a-c256d35faf11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P35364"}
{"id":"6254c154-9d0d-40f8-8865-5d01eeac627d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11224758","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:7733065e-1075-41ee-8be9-db92529c1201","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8435","original_object":"UniProtKB:P28223"}
{"id":"71c7571e-b02c-4361-be21-d03f3b616a0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P909HKP24","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:1c72eb6e-6c4d-48dd-b6d0-79de6cfb31d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1216","original_object":"UniProtKB:Q9Y5N1"}
{"id":"34c02134-a4cc-4718-9bba-6bb72fff64e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5487529","predicate":"biolink:affects","object":"NCBIGene:6581","sources":[{"id":"urn:uuid:1b43e4ae-9a09-4053-bf56-7147c6051012","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8826","original_object":"UniProtKB:O75751"}
{"id":"43ad033a-779d-4fea-99e6-1431e6f6b58a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3921","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:b13d53dc-5e06-4d23-8155-c1d662647550","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2413","original_object":"UniProtKB:Q17ST2"}
{"id":"67c0b5ff-ef10-4f6a-ad9d-c349f7051d0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16714","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:09f0e699-7241-47c4-9db2-d99fa5b44e6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1673","original_object":"UniProtKB:P35372"}
{"id":"5da3f3e9-2a7f-4105-bfbb-7a5439d1f0cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:2df10f4f-4c98-4ed5-8b00-0e0a6f003278","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P43114"}
{"id":"cd989476-60fe-4017-8835-703688ee4b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:605fa598-c61e-4fad-9d1b-af22f3394d49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P32305"}
{"id":"44481dd2-c71b-4e63-98d4-f6307edb316e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:5c69b371-05e2-4a67-8513-e4b192eef798","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:Q14416"}
{"id":"a997f708-efbc-4a9f-8f2a-28940ee8ec9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4981","predicate":"biolink:affects","object":"NCBIGene:3601","sources":[{"id":"urn:uuid:8b9c925a-05e3-4a85-9044-ed3aae57695d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4981","original_object":"UniProtKB:Q13261"}
{"id":"870e9853-e0d8-4039-875e-289f62f7f602","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50922","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:410997b8-232f-4ba4-90e3-ea5e2de915fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:40","original_object":"UniProtKB:P08908"}
{"id":"95e6e826-20fa-4ba3-9f74-6be60ea565b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1019881","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:8f2330e0-8a1b-4519-9b5a-1fe3acbb2c2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1430","original_object":"UniProtKB:P41594"}
{"id":"0018e88c-c143-4f3f-bd3a-e138b28104ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4S4LA22APY","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:d13637b6-ecf3-40c2-b72e-3dec6c42282e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2217","original_object":"UniProtKB:P47901"}
{"id":"2e46c280-1866-4a80-a26f-385e04a93efa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75W6I8W6OU","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:a02d63de-89a8-44c3-bce1-e92875795c61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4249","original_object":"UniProtKB:P42261"}
{"id":"0d0a07d4-929a-45d9-a8df-a770fdbdae0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:c71edc53-19df-4468-8da2-56727a08fb94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P28566"}
{"id":"dbf5bcb7-792f-4f05-b826-ceac854190b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73349604","predicate":"biolink:affects","object":"NCBIGene:332","sources":[{"id":"urn:uuid:9bfe777a-b317-4eb8-be90-fa3cf372234f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8825","original_object":"UniProtKB:O15392"}
{"id":"2b73e978-f35c-4628-9b27-6ccaadd013e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:4a7f8b96-fdb9-470a-9aa1-5d114df19828","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:P14842"}
{"id":"0485acb5-a3d0-4fb9-af70-238e225e814b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136046","predicate":"biolink:affects","object":"NCBIGene:5566","sources":[{"id":"urn:uuid:d9562175-209d-42b2-ab38-eebce3d37003","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10423","original_object":"UniProtKB:P17612"}
{"id":"fa47a051-525e-4458-92c7-defacd440c97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:646ccdc3-f766-4e52-8d07-47117a7391f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q8NER1"}
{"id":"3c2f66c5-286b-4182-bd6a-3958439f6750","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85973","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:62df8e5f-9e19-4278-9d83-d05be6c57d26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7575","original_object":"UniProtKB:P00742"}
{"id":"49a6e4bb-719a-4584-b54e-91f8427fd393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:74592935-b586-455a-9ade-e6b257b1a9bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P20309"}
{"id":"49f69cc1-a3d0-4686-8c2f-7c7c030d366a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2178734","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:52050d4e-98c9-4b23-b18c-135c400cd704","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5974","original_object":"UniProtKB:P06493"}
{"id":"67b2cc83-0435-448f-89e9-ca2d4fb21c1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:127534","sources":[{"id":"urn:uuid:0f49d3c8-21f3-4c1c-b745-93d5b1c521e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9NTQ9"}
{"id":"998a3499-6930-473e-b91a-b3a6d4fdabeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34457","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:5da2c5ca-2edf-4dd9-8513-f24face812dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4270","original_object":"UniProtKB:P51788"}
{"id":"f6aa5dc1-f070-4196-8ee3-d192c383cdf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:04c1ee09-b913-4869-94a9-8bae45fa6c7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P29274"}
{"id":"89555a31-699e-42f9-a268-cf3ff8a1370a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312129","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:9d9a9869-10c9-4114-86ba-361eb1281199","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1952","original_object":"UniProtKB:P35408"}
{"id":"212c4ff3-74a0-4484-b340-31a32c91bf5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195544","predicate":"biolink:affects","object":"NCBIGene:80834","sources":[{"id":"urn:uuid:3172e99d-c04e-41d5-973c-a57f1985751f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13899","original_object":"UniProtKB:Q8TE23"}
{"id":"f90a9a92-683c-4421-bd22-60707cc731c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23657507","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:d71ae0bc-825c-440b-8eae-15e767a7a870","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8146","original_object":"UniProtKB:P43405"}
{"id":"bc6c356e-345f-4c9b-98f6-5b5dbd6de1f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3DRR0X4728","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:2973a19a-4cfd-4767-ac82-0d9dbcd15aaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12286","original_object":"UniProtKB:P24530"}
{"id":"ef60fc54-29e4-46c5-81c8-f3259b5f0431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:c26bb79d-d5ae-451c-a7ee-313049bb8bac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:O60755"}
{"id":"563856fa-dad4-4da1-984f-93bf959ce6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5583","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:d9856879-ce38-4089-8659-2f801a5219a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5583","original_object":"UniProtKB:P30968"}
{"id":"cdfe08c6-b1fe-478c-9e83-64a23772b348","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431484","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:271292d8-0062-443e-bbf4-4a98bb3ebcca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10124","original_object":"UniProtKB:O00519"}
{"id":"2810728a-2ec0-4d45-abf8-e259490250eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:a2943ba3-0147-4904-b1ff-da7c5ed0b9f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:P43405"}
{"id":"1a79323f-3ff4-4031-b49b-c913eef3ecc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321153","predicate":"biolink:affects","object":"NCBIGene:10765","sources":[{"id":"urn:uuid:361ca288-6867-4e1e-b2fb-7c391ec20b8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10141","original_object":"UniProtKB:Q9UGL1"}
{"id":"20bd8192-f4f9-4cea-9210-8f5fcdb893e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1790","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:e64247fa-791a-47ba-a11f-20db228399ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1790","original_object":"UniProtKB:Q03431"}
{"id":"c2056adf-42de-40ec-85b0-d70757f96351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232539","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:9b293190-e166-4aaf-ad3b-8324fe013037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4605","original_object":"UniProtKB:Q01959"}
{"id":"4dd6fec9-8722-4223-bde4-4e05bead1bea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64191","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:c4cc3347-ecb4-46c0-a591-fc3c66b958ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:44","original_object":"UniProtKB:P30729"}
{"id":"2ad4e120-05e5-4020-b52e-eb2db6d8f570","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57381425","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:10a655cb-34d0-4cd6-ba68-b240b65990a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11120","original_object":"UniProtKB:Q13547"}
{"id":"46077a22-e603-4b0c-8dfe-d58646cdc210","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15951636","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:defe0619-0f56-4c70-b27b-92e83fa585d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9893","original_object":"UniProtKB:Q6V1X1"}
{"id":"7b81ad86-cd51-49d8-ba17-97aab7e82237","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755088","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:bb736f1d-ff00-4a54-9231-b98e71e17a2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4276","original_object":"UniProtKB:Q12879"}
{"id":"28ad54b3-6b2d-4072-abef-54d7d2245ef1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:c9465579-da18-4a77-b2c8-718b231ca9c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:P21554"}
{"id":"7e3392da-bf0b-4f8e-95c1-dfed511cc9b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:a89b425a-e0b3-495b-9546-9b2c6d115fe4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P30966"}
{"id":"03ffefd3-aadd-428e-bee2-4e9bd9bca83a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O6NW23A765","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:349630c1-5089-45f6-9194-acb04ade407c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3986","original_object":"UniProtKB:P36544"}
{"id":"332afbec-9312-4500-a563-c028d513117e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10835443","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:5c99fa60-045e-4cb4-ba88-905bd065f8a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11955","original_object":"UniProtKB:P10276"}
{"id":"902f04ab-513d-47a5-92af-2b904125a201","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71952","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:6b717632-6ce6-4e8e-999c-7066c6982f59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7950","original_object":"UniProtKB:P42345"}
{"id":"b39c28bb-9aca-4466-8e2f-2852e090069d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817386","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:b9d90422-71b9-4eb5-b6f6-8f50539fd8e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:992","original_object":"UniProtKB:P25101"}
{"id":"991529e8-a139-4a80-8f1e-0e388d9d71bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:764","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:94ebcd49-e238-40f0-9452-e65a57e7ef82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:764","original_object":"UniProtKB:P51677"}
{"id":"9f0b6320-932f-4a7e-b9ce-202a2e804dd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135983","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:ccb59605-7197-4647-b9c6-4c2de3aafb38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4448","original_object":"UniProtKB:P49190"}
{"id":"eb9c6a2c-a9e2-4af0-854c-df58b9310114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85299","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:1d0166ef-5de4-4b2b-919b-e259419c2f68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3621","original_object":"UniProtKB:Q8TDV5"}
{"id":"b5d7ed9b-6b4d-4453-9b1b-7abf75ac3b93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:347732","sources":[{"id":"urn:uuid:5843496d-c996-4360-8199-6c214913a63e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q86XQ3"}
{"id":"2a2546a8-edb9-4be8-9393-e39fa590745a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44566108","predicate":"biolink:affects","object":"NCBIGene:6257","sources":[{"id":"urn:uuid:2319b195-bc6b-4c68-a83f-51a7b736b25f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2816","original_object":"UniProtKB:P28702"}
{"id":"0b66be0c-c086-443d-b2be-8b5892c86b56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23549991","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:38d4cf2a-456c-41c0-ad16-3fe3f718e9ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9574","original_object":"UniProtKB:P47871"}
{"id":"d1d30c83-2345-4709-9530-c91d5ec9a6d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4312","sources":[{"id":"urn:uuid:220baa2a-cb66-410f-b132-86d7797ca38e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P03956"}
{"id":"48bf6a77-7350-4633-8c8d-221497d497dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11655079","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:dd907bdb-5dc9-48c2-8fd9-49b43ea81e6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7725","original_object":"UniProtKB:Q13133"}
{"id":"2e11e8a0-bd79-456f-ae04-03cdbf8bd53e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868452","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:bee85dde-d15f-489b-a41d-88ebb1f33d5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:129","original_object":"UniProtKB:P28335"}
{"id":"1124780b-1d92-4995-8f15-b096bac95d86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:c1304a65-af23-4588-a952-7385e95d3fc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:Q14831"}
{"id":"2ece5b2f-5dd6-411e-a6d1-367e270be1c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164437","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:47d699a5-a49c-4523-ac8e-56dd71397e98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:373","original_object":"UniProtKB:P29275"}
{"id":"3ba098d2-9c13-45da-9f78-77a54af47f7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166472515","predicate":"biolink:affects","object":"NCBIGene:24145","sources":[{"id":"urn:uuid:68fd45f6-e56c-44e1-b906-99667061d8db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13604","original_object":"UniProtKB:Q96RD7"}
{"id":"ce5d6751-fe9e-4b99-8c80-f10e7748d0ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47499","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:2483d5b0-0413-4c8c-aa38-b48e5b6c273d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:357","original_object":"UniProtKB:P23975"}
{"id":"c33de50f-64f5-4797-8e82-05553a25e097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280454","predicate":"biolink:affects","object":"NCBIGene:5165","sources":[{"id":"urn:uuid:adc57175-dd98-442d-8e52-4a1b5eb87a54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9350","original_object":"UniProtKB:Q15120"}
{"id":"4f32d118-3d7b-42a1-9079-f8569bd69c25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15608077","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:81a1cecc-5056-4eae-82a4-f266875671bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1217","original_object":"UniProtKB:Q9QYN8"}
{"id":"88da0f5c-241e-4798-8d7a-800ed37edd1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8718","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:403ed057-7a25-4718-bfff-17f8ba9aba6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8718","original_object":"UniProtKB:P25092"}
{"id":"a9dd5215-f31d-4ef6-bf5b-962fa5a0f7ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92848","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:e9dc57ed-08f6-4f44-bbac-fa6fc027cfe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3286","original_object":"UniProtKB:P29275"}
{"id":"0e03c974-734b-4da9-8118-c3d21a6a39ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:54257","sources":[{"id":"urn:uuid:3db765ab-c385-4698-b357-0f8d53c7aaca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4231","original_object":"UniProtKB:P42260"}
{"id":"6134d633-8184-4715-9c41-a47a9d2af083","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231693","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:5441bbf1-130a-4dae-affb-30c981e3ef28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7904","original_object":"UniProtKB:P08581"}
{"id":"071157ff-1141-4fc0-9044-cda5596cc515","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71654771","predicate":"biolink:affects","object":"NCBIGene:23410","sources":[{"id":"urn:uuid:cb205747-0452-4286-91cf-3c1a8704bbaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8778","original_object":"UniProtKB:Q9NTG7"}
{"id":"d544b162-64f8-4292-94a9-1fb4e9c0e669","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL499968","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:1b6cc270-54ec-411c-959f-c177a65e4922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2317","original_object":"UniProtKB:Q9UGI6"}
{"id":"30639f81-a9f8-4ded-9b96-c3cb06c2e6bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146188223","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:c1a21a6e-acf8-488f-a159-1bdabde5703f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13359","original_object":"UniProtKB:Q86X55"}
{"id":"f84d13e1-1051-4a19-9f50-ec2b3050c102","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:529ca308-f003-4cb8-8f71-7fe581a98066","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P35916"}
{"id":"08efc402-ee4a-47e0-bcef-efadab0064ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8481","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:e6d75816-3f9a-4e71-bf80-4de125d7ff3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:329","original_object":"UniProtKB:P11229"}
{"id":"487e54ab-30c9-4d6a-9930-14f764ebbcd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:47b2aa0f-c4de-44f7-9bc9-cc27dc72db77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:Q14832"}
{"id":"48a0560f-d93c-44e9-935f-e07d15414b2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75984","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:57342da5-6959-4e13-8a68-e8378630637a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2560","original_object":"UniProtKB:P22460"}
{"id":"6e3f3f3f-142b-4254-a70d-d93c6603d302","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3084","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:d4a99df0-4d81-4e08-ac7e-b9da4b34885a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:297","original_object":"UniProtKB:P08482"}
{"id":"c2d5d5e6-c831-4b18-8a3b-e715b24348b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:92dff583-8793-44b6-9bd1-e6f076d0c600","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P32745"}
{"id":"7aa555f1-396d-4ec7-9271-fd97e1661580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:57e017be-5f05-4ba3-8512-ffcde707c3d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P35916"}
{"id":"51a03963-0d51-429a-8d0b-1209462a90fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8R4A7GDZ1D","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:225ac79f-db04-44f8-933a-901553a3f393","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7034","original_object":"UniProtKB:Q15059"}
{"id":"2730641b-fab0-4a18-9b50-f3f0544f73bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918583","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:fbbfe7b0-8d08-4b96-bd0c-592bf511b6cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4257","original_object":"UniProtKB:P14867"}
{"id":"ea52667d-1661-4163-8c86-42f1193a057e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5779","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:6bec4bc7-241c-4aa1-8754-343de1b81887","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7081","original_object":"UniProtKB:P35372"}
{"id":"4169ffc3-1daf-40ea-87e2-152322b46af2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:970375","predicate":"biolink:affects","object":"NCBIGene:5650","sources":[{"id":"urn:uuid:27741173-3b33-4c81-9b1a-0bad3b24b670","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8488","original_object":"UniProtKB:P49862"}
{"id":"08d30c33-74b7-4730-80f9-827524973820","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9342","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:c49db77a-e75e-4103-a72b-4c7a6c15ae1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5826","original_object":"UniProtKB:P21462"}
{"id":"03f16d27-d201-4a4f-b95f-fee361dc0a4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5768","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:1e49f66c-9805-4f66-8c68-f8e519d1576c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5768","original_object":"UniProtKB:Q9P296"}
{"id":"c48c24fa-0491-496d-a944-5ed1871999f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:3383bc24-3191-46ac-bbf2-dc446faae008","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P11802"}
{"id":"35a85334-5300-4179-b5ae-ca11372ff4d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45980","predicate":"biolink:affects","object":"NCBIGene:590","sources":[{"id":"urn:uuid:81d6e5cb-8ef9-4f0f-ac3d-e83c9469291c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6687","original_object":"UniProtKB:P06276"}
{"id":"0ebe036a-ec5a-484b-b935-edb81e22f5e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7872","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:b758106b-ac00-4cd3-a28c-d611fa7fb4c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2174","original_object":"UniProtKB:P30559"}
{"id":"a5e65d60-b30e-4e4d-b6c1-49e923b5d917","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9GH7E6347B","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:f37664cd-5a6d-40f2-9521-d7c8c8ed6fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11969","original_object":"UniProtKB:P56373"}
{"id":"453aca46-7d5f-418a-8d06-ee7cb163b4ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NL5EEM9E2G","predicate":"biolink:affects","object":"NCBIGene:171087","sources":[{"id":"urn:uuid:c745cfe3-46a6-4a54-b9f0-756b97c59b9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11300","original_object":"UniProtKB:P63031"}
{"id":"3bf98b86-d1a8-4a2b-ac70-5056d4c827a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317097","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:4863226a-6168-48c7-a0c6-889ca3ca8eab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7724","original_object":"UniProtKB:Q9P0X4"}
{"id":"be4f40ef-0357-4d1c-aff0-20423c772e1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44595851","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:d44aca9f-767e-4746-a6a3-ed54df3a3928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6259","original_object":"UniProtKB:P31421"}
{"id":"40d9be0a-3428-4077-b2e5-a670d8f1448b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56694877","predicate":"biolink:affects","object":"NCBIGene:1613","sources":[{"id":"urn:uuid:8af7ad65-8ccc-4eee-99ba-9c2b31d9b554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9422","original_object":"UniProtKB:O43293"}
{"id":"37bfe144-4187-4b90-ba4f-3b3f3faafd26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5646","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:9c8b015c-56f5-4dc8-8fcf-a6eeb8d4cb11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5646","original_object":"UniProtKB:P30874"}
{"id":"91509623-9e1c-4191-b03a-3efbffb28e9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135613","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:ad95cefb-e774-4e34-9ea7-bf64b247fde0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5596","original_object":"UniProtKB:P29274"}
{"id":"18286bad-355b-4bed-a342-880ecf3b3c22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:1e37d04f-dceb-41d8-a4ff-bcc4986d9bf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P43119"}
{"id":"cfe6c058-dba9-4c90-b8bb-638089c468da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:51776","sources":[{"id":"urn:uuid:11df29d3-39c5-4e0c-9958-d2b399be5ec6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:Q9NYL2"}
{"id":"20a00c7f-5f4f-4fa0-ab24-e63f5cfbde02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5481119","predicate":"biolink:affects","object":"NCBIGene:117029","sources":[{"id":"urn:uuid:d2e83803-e020-495f-9a05-eb624e79bc77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3651","original_object":"UniProtKB:O08556"}
{"id":"df065ea5-ab44-4a98-93d7-36a0a42860cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233306","predicate":"biolink:affects","object":"NCBIGene:4296","sources":[{"id":"urn:uuid:7afb595e-1bd6-4568-8e81-9db73590954f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13067","original_object":"UniProtKB:Q16584"}
{"id":"dda65e68-fe63-442d-9944-6f8cfcc8425e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b02355e8-3bca-4896-88a2-73b3133adea2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P08908"}
{"id":"7d5f3d97-ae0f-4885-bc28-00701caef2d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19DG7G1U5Q","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:b4a8cc03-677e-45a6-a980-51eaab5e5dd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8917","original_object":"UniProtKB:P42338"}
{"id":"e1d17bce-f60b-48b9-84c4-da2fed98bc69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1794","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:d356b5a2-6e24-4797-a1c2-403036e11956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1794","original_object":"UniProtKB:P25961"}
{"id":"04fb0aa6-a036-4e40-8496-78cf6f90fd6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311382","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:4f8c42ee-ff0b-47d0-9b71-e09e15a6599c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8183","original_object":"UniProtKB:P12931"}
{"id":"b5982c0d-81e7-4be1-b2cf-bd47c3fc1983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:2870","sources":[{"id":"urn:uuid:845b5c4f-68f1-469c-8087-d935c34cd85a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P43250"}
{"id":"8856bfe7-28ba-4df2-b814-4504a2e7508c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9800175","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:9e9b1dce-5809-4867-ae78-0e882ce2238d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1071","original_object":"UniProtKB:Q9Z0U4"}
{"id":"b795eef7-4ea9-477c-9804-0ab83048ada5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41423","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:aa7d1e4e-fd34-4673-b5fa-608b8022225e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2892","original_object":"UniProtKB:O43570"}
{"id":"ed9da99d-480d-4e4c-a111-18dbfaaed58f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9839317","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:0699eab1-bf9b-4b5a-9660-27a4054f245b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:518","original_object":"UniProtKB:P25100"}
{"id":"efd110c7-8e89-474e-9893-6817edb7fdce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:24814","predicate":"biolink:affects","object":"NCBIGene:11622","sources":[{"id":"urn:uuid:068f0165-9f1e-4b04-b44f-8c026f7d49af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10047","original_object":"UniProtKB:P30561"}
{"id":"4a345263-a9a8-4924-a66b-28c20e8b16ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73355065","predicate":"biolink:affects","object":"NCBIGene:9817","sources":[{"id":"urn:uuid:ca0b310f-e1b2-433e-9791-95ab96530fad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8772","original_object":"UniProtKB:Q14145"}
{"id":"87a547ba-d453-4136-ba2d-9467b4218406","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:8b34c86b-035c-424a-a6d3-9a8a3a3447ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q7RTT9"}
{"id":"2dbf7f22-ee4a-4afc-b9a7-c0894eef7392","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92314","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:63afb961-8ed0-4d59-89c7-e8e2e848ce11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1692","original_object":"UniProtKB:P41146"}
{"id":"cdc80802-a3f7-40e1-9b66-fdead5d4e372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46216676","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:5d49a497-2f44-40b5-b642-45a8dbf4e9e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3367","original_object":"UniProtKB:O14842"}
{"id":"029c8df3-06d0-42bf-a315-9a6cddc21dbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146212008","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:c17f88fe-8872-4607-9a8d-4a68c263ba8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13457","original_object":"UniProtKB:P42336"}
{"id":"1a684fb1-f5e9-4fb0-a05e-f82fe9d94a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34018","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:11db55ee-2325-4180-be51-a7e9350513b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4131","original_object":"UniProtKB:P42263"}
{"id":"2d01fce0-0a3b-4246-9123-de385f528623","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3387","predicate":"biolink:affects","object":"NCBIGene:8325","sources":[{"id":"urn:uuid:b577e91a-f001-471c-bf2a-71d8092b699b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5339","original_object":"UniProtKB:Q9H461"}
{"id":"d0f23620-523d-4cff-a2cb-5483575fed30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:eac93230-0c34-4e4d-ab61-323d6379d377","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P32305"}
{"id":"6cf7bdf7-cb96-4fed-bb26-7f7ed9e6f96e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2K59L7G59M","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:e464ae65-320a-43b2-9553-590ce38cfacb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9728","original_object":"UniProtKB:P42338"}
{"id":"441659cf-1c42-48cf-8893-44ce14de1f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93427","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:beb8563c-698e-4638-8195-9db6c12e919b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5970","original_object":"UniProtKB:P36888"}
{"id":"6f791aa1-2ee5-4381-9528-e0ab38e353c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13846","sources":[{"id":"urn:uuid:efb7576c-8e63-43b4-9496-efbde9149fe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P54761"}
{"id":"c373f81f-7e91-48e0-a979-27daa897858d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2684","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:39ad131a-c53d-475b-a6a3-a5c0ab9ce53c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9658","original_object":"UniProtKB:P20309"}
{"id":"178bae9f-20eb-4086-aca1-a6aedc10256b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3901","predicate":"biolink:affects","object":"NCBIGene:4158","sources":[{"id":"urn:uuid:5aff1745-f2c0-40e5-826b-4003a4d93505","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6965","original_object":"UniProtKB:Q01718"}
{"id":"bcedb9e6-5be9-44f5-95c1-a381ca358182","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129202507","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:bd838af8-7a85-445d-8998-01a33cfaa7b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12076","original_object":"UniProtKB:P11802"}
{"id":"7b07ced2-ad1f-4b56-a922-501de8cadd30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U9MOX60GHD","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:2035a828-4e11-416e-ad69-c4572675d955","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12603","original_object":"UniProtKB:O43613"}
{"id":"2fb04375-20f8-4921-beaf-57d49be87307","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:94a4d8b4-58f6-425a-90c1-837b21bbd3fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P14867"}
{"id":"44751bea-6fb1-49e0-a6e9-58db8d70ebfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3VF7K7Z10B","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:57fc903a-5e20-4b3f-9daa-f43610d2d579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9621","original_object":"UniProtKB:O35433"}
{"id":"9bc35d53-6b04-459a-853b-5ff939b51b4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C6RWP0N0L2","predicate":"biolink:affects","object":"NCBIGene:10114","sources":[{"id":"urn:uuid:7fb8ddf0-cf7f-48d7-b500-b25c012fa195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8126","original_object":"UniProtKB:Q9H422"}
{"id":"f6ee98a7-edce-4312-a9ec-c9820df4dcc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:c7b1df50-a28e-4b99-aeef-367c682fa79e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11859","original_object":"UniProtKB:Q9H2S1"}
{"id":"6d38694f-1c28-432c-80f4-ee45303bee60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:afe9dbb7-b3e3-44f9-b2e4-5d77f83c6215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P14842"}
{"id":"848e54fb-764e-43a4-9369-852d50105947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194387","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:ba2c775c-1275-49a7-808c-4ab38c4da8ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1393","original_object":"UniProtKB:O15303"}
{"id":"1bb5cbde-24e6-448c-80aa-ce9c49ac16c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368936","predicate":"biolink:affects","object":"NCBIGene:340156","sources":[{"id":"urn:uuid:3ac1ea0b-4f28-433f-a138-589722dbcaad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12185","original_object":"UniProtKB:Q86YV6"}
{"id":"50beccb2-ce6c-4a14-992f-86510dd9d5ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60528","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:b7962253-7bd1-40e0-b66d-2ec48be52b28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:123","original_object":"UniProtKB:P28222"}
{"id":"550440e6-ac30-479e-ae93-f30d3ca49006","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230107","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:5f35ec46-c69b-496e-ab38-14bd0db92c35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1633","original_object":"UniProtKB:P41145"}
{"id":"23a0d6ba-8816-440c-b813-a615fddb07e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17303","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:f9391000-226c-4c35-96fe-5d5e7800b315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1627","original_object":"UniProtKB:P35372"}
{"id":"36af61e6-d639-4c0a-99d2-462f99d88310","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:b3d7e69b-f4bb-4c77-baab-9c81abf1a15e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P14842"}
{"id":"c6460e0d-6af9-4e1d-b5b1-182dda6dd5ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:4c365211-9b0b-4429-a8c1-2aa8c275eb1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P30994"}
{"id":"e581e09d-4860-4095-bc19-9c168bd3259c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366980","predicate":"biolink:affects","object":"NCBIGene:6789","sources":[{"id":"urn:uuid:10ceaf62-995d-4948-a961-e9bc72338f66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11811","original_object":"UniProtKB:Q13043"}
{"id":"5eb39e07-7660-40a3-a59b-b2d6b68c3e3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9017","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:29b94df2-b6d7-4b51-838c-68b48e2a6b8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13093","original_object":"UniProtKB:P22748"}
{"id":"ea234659-8d37-492e-b0db-57fdcef736a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44134520","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:64efa796-c227-490e-ac3e-86a9df31effc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2257","original_object":"UniProtKB:P32215"}
{"id":"d39b7b90-b3e3-4042-aa15-5b67b7b00f34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:868700","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:ad478de2-dc33-4a04-a05c-717c909850e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11561","original_object":"UniProtKB:Q9UGC6"}
{"id":"3b8b95da-6938-42e2-9430-74066bb60299","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87103","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:e1c70a71-ffd8-40a2-b06c-7c26f94fbde4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5992","original_object":"UniProtKB:P52333"}
{"id":"09291d9e-5418-4e8d-a81e-767985336560","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12516","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:5f477ced-a2fa-47e3-84bb-e07f217a7272","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12516","original_object":"UniProtKB:Q9P296"}
{"id":"a8d279f0-a52a-47fc-8eeb-53895f672f4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LDR3USH1NJ","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:7868753e-9611-4681-ad7d-e063c41bb717","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5612","original_object":"UniProtKB:P29274"}
{"id":"fc085621-f6d0-4b9b-8e50-488f75e8fd00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LJA4M1L5LG","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:73359b5d-929a-4e74-a020-22fb20c009ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5595","original_object":"UniProtKB:P0DMS8"}
{"id":"ce4acc86-23cb-4216-a782-3cb594d870d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587567","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:b017a44f-286a-41d6-b1c0-4b89e1cb9194","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11696","original_object":"UniProtKB:Q8TDU6"}
{"id":"a9b22f46-55d5-4757-aaec-a71236bcf01b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:33639WNC7Q","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:4435db11-a7e5-4da8-9e07-1283cdfdce1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8793","original_object":"UniProtKB:Q8NEB9"}
{"id":"02688bb1-62aa-4a26-9c70-651a36d6c1cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56847486","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:304121b7-dfb4-44a6-b254-5eccc1767c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8247","original_object":"UniProtKB:P30530"}
{"id":"3f4dfd38-e1b7-4e69-be41-15b60a8f2a8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92890","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:f7488db5-a045-4c7c-ae6e-f09580724f07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5923","original_object":"UniProtKB:P24941"}
{"id":"0b460f3d-189f-4d59-ac7b-361ee37c4c8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:bdc4fb2e-169c-4bca-874c-acacebcc9e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P51575"}
{"id":"915bb4e6-7feb-4cd2-a34d-24c620f6519a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358908","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:f8e634b6-8ceb-4909-a5d9-9d2122116ccf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:344","original_object":"UniProtKB:P08172"}
{"id":"d76c823c-7f58-45be-b2d0-97a20c811f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:aaa5e12b-1b2a-483d-af64-833195fc172e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P10721"}
{"id":"99269c1a-5d1f-4a70-9dc8-ebb733d7507e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:07YMO87363","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:7b74759c-ab59-4e96-990f-2eda0a6da024","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9826","original_object":"UniProtKB:P42336"}
{"id":"163053c7-e4d1-4081-86d8-f4c15fb6ca21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93472","predicate":"biolink:affects","object":"NCBIGene:27115","sources":[{"id":"urn:uuid:0cffac65-48c6-4917-b1f1-f557a59cf155","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5154","original_object":"UniProtKB:Q9NP56"}
{"id":"c2b93284-2201-4b4e-a1bf-3327412dce40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:6efeedf0-7ac7-46e3-b054-0fcfd46449d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P35367"}
{"id":"d28e66af-940d-4802-968a-625bcc3de2ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12035","predicate":"biolink:affects","object":"NCBIGene:63036","sources":[{"id":"urn:uuid:f612634f-6c26-4290-be54-b201d32a4693","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12035","original_object":"UniProtKB:P08217"}
{"id":"968b873b-7c47-468d-845a-1a6f4f6a850d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:12000062","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:699bc47a-d9c9-4f5d-95c3-a85ab9309ea2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2502","original_object":"UniProtKB:Q9EPK8"}
{"id":"388dfb7f-5bd4-4cb8-b06f-f2fc03a7195a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:a89064cf-1848-4949-ab06-5985b797dcca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P43115"}
{"id":"a724b980-9ac8-4a98-ae86-1160e18114a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LMQ24G57E9","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:e226b0a1-4ad1-4591-88c2-97baa6abc28f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11648","original_object":"UniProtKB:P56718"}
{"id":"c1895fe1-de40-4915-92c9-e1d26cb292e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358779","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:a1e3cb84-f77c-44c5-a3e3-0e3e9f251579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11970","original_object":"UniProtKB:Q9NYA1"}
{"id":"d1e41f69-dffc-40c2-9ef2-47e1823c8744","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188895","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:f3c44d90-2a7f-4812-9228-4aaabf5d6a13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:196","original_object":"UniProtKB:P30729"}
{"id":"5bdd022d-9395-46a6-9c4b-0b3bdd3226a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73337","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:0380f6a8-0fdc-4aaf-9a3a-41a21af4b8e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1236","original_object":"UniProtKB:Q9QYN8"}
{"id":"e0cfb6b1-fc58-4963-b852-3faab2313872","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3B512HJD65","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:a3cd0e25-9a26-4210-97ea-4c255a40fbd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10426","original_object":"UniProtKB:P24941"}
{"id":"d85140b4-2f07-45c1-a02a-58a7ce02fd6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:65272","sources":[{"id":"urn:uuid:c88789fc-0bd7-4d47-9031-cc52c55a5312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q9JIS4"}
{"id":"c55b8b0d-cb61-46be-9564-2275fef453e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189512","predicate":"biolink:affects","object":"NCBIGene:291","sources":[{"id":"urn:uuid:b4241d12-8c8c-4a19-99c6-60e971322768","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4572","original_object":"UniProtKB:P12235"}
{"id":"7fc9ee2b-d787-4562-99da-d6850b8ccbfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:2268","sources":[{"id":"urn:uuid:0d4567a2-dd50-41ce-8de1-a32b99edcc04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:P09769"}
{"id":"903f3e05-393f-48c1-b2f0-bbc243b1ed46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141046","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:fb292eb1-2e15-4d46-81d0-0ddb334e5975","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1926","original_object":"UniProtKB:P30557"}
{"id":"5dbe0c69-d812-4b26-baf1-ca1d6058c0eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2221","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:e9190316-8a22-4b23-b732-2c7c2bff6691","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2221","original_object":"UniProtKB:P47901"}
{"id":"3429ab45-0302-498e-9ce2-f9619c2e7ffc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2206","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:8cc537d8-3538-4849-aa96-7942a8b5d14f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2206","original_object":"UniProtKB:P37288"}
{"id":"157a90fb-084f-4f8b-b077-603daef155ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59751","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:2b2082d1-6e6c-47ef-a0ab-77b906bab9d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:878","original_object":"UniProtKB:P32239"}
{"id":"6040f34c-104b-4f96-b308-9799ed11b03c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4786","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:3b642da3-1659-4ec4-a6d3-801b21a7167b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6332","original_object":"UniProtKB:P12821"}
{"id":"495a525d-2fe2-4c9a-a3df-7eba8893a8ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:b56bbe3a-faa3-442a-9ff8-a6dd3051a3de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q13507"}
{"id":"aede3097-3e40-4b64-937e-af95377ee7ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11457116","predicate":"biolink:affects","object":"NCBIGene:487","sources":[{"id":"urn:uuid:998de534-b6af-487b-8634-72c67bc2c463","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8822","original_object":"UniProtKB:O14983"}
{"id":"3d15b77e-8589-402c-a069-f7a059f2dbbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827339","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:84915b3e-005f-4458-adcc-584c7aaf41d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:369","original_object":"UniProtKB:P30542"}
{"id":"33fa1758-a5e7-460f-97bf-66fe4e440145","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:3e931785-7a7b-44d4-baf9-7d1a30b70bf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:O88854"}
{"id":"fdb09a13-3dd1-4882-aa48-7b478942319c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167662","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:297b4168-12de-48c1-99e0-e63a2ecca594","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8943","original_object":"UniProtKB:P15056"}
{"id":"83f670c7-4507-494d-8cb3-484dad2963fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:172267","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:06ebc99b-3595-4ba5-a7a5-64af63d9ba34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:128","original_object":"UniProtKB:P28334"}
{"id":"636c9904-a525-4653-a6f0-dcc05dcf00af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996528","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c0c6bbf7-a0ed-4044-b61f-e695848d82a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10603","original_object":"UniProtKB:Q13258"}
{"id":"43b0f1e4-98b3-4743-b41f-71d5a8be7a49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15984632","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:bc8fd1ee-bbba-4563-bef9-ea3c770868e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1943","original_object":"UniProtKB:P32240"}
{"id":"2492b266-86b7-4881-bb7a-2d53dc60b40a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:6789","sources":[{"id":"urn:uuid:cefa36aa-0904-412c-b8a5-0a262b9bd6d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q13043"}
{"id":"b40eab58-0a34-45c7-82df-1f797d453a72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:182HIJ2D7F","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:a8fb3fca-de9e-47e8-8b12-f0556f103d4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6347","original_object":"UniProtKB:Q8NER1"}
{"id":"ec65b349-83a2-4ab3-a456-f82d972b22c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:994c4e77-02ac-47eb-9459-0c2c8e40da60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9Y5S1"}
{"id":"ed58b8d5-8c76-4966-8988-619b235eb04b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1150","predicate":"biolink:affects","object":"NCBIGene:24953","sources":[{"id":"urn:uuid:74279152-b139-42b4-b8b9-73a3da184b22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1150","original_object":"UniProtKB:P30082"}
{"id":"cf0650d6-9c2b-477e-9917-5d15f4901abf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142183","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4cf960bb-260b-469b-9a67-26ef481e06da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:166","original_object":"UniProtKB:P28223"}
{"id":"37197953-cf61-4223-bdad-d645f8f95153","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9747","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:7cc94e34-eeac-4ac4-8274-0874d83d08aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9747","original_object":"UniProtKB:P41146"}
{"id":"ea5d5e70-45e9-4698-a8c8-b97815c22598","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11465","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:9ac7bc82-861b-424f-804f-92db1fac8ef9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11465","original_object":"UniProtKB:Q8TDU9"}
{"id":"3e7db02e-4d21-44ad-a898-77a54d5ecd38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311007","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:14cd6b60-0120-42f6-99a0-b2293c83b316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:739","original_object":"UniProtKB:Q14330"}
{"id":"bbe91f24-b06e-41e8-96c3-44931b7bd768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2034","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:0c84a3b9-5b44-44fd-8588-ea5b3dbe8a33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2034","original_object":"UniProtKB:O08858"}
{"id":"22c0d6c1-a730-4190-b4ce-8c52747ac48b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81388","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:76c872ef-3cb6-4979-8c89-00a540080e83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1193","original_object":"UniProtKB:P35367"}
{"id":"18006a7e-1d34-4631-83b2-0470c4ccee3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR9ZYH80Z8","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:8a04e7e1-53f7-4a0b-98d1-4685873ee445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9787","original_object":"UniProtKB:P22607"}
{"id":"446b11d1-a2a5-49b0-9558-1249451018fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11366","predicate":"biolink:affects","object":"NCBIGene:2160","sources":[{"id":"urn:uuid:e9209ccd-5dfd-4ed9-9c0c-2d195fb8aa0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11366","original_object":"UniProtKB:P03951"}
{"id":"b1c8bf95-c360-4dd9-b873-973384a79100","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553158","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:4f2095b3-ca13-4902-9e62-34fb8ac041fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10217","original_object":"UniProtKB:Q9NRA0"}
{"id":"06c12bd0-62bf-4b9b-a282-384b752197c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93369","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:fe891055-54d2-4a75-a69b-474401eb57ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:85","original_object":"UniProtKB:P28223"}
{"id":"70d7b235-c05c-478a-b60c-4a5cf5d30d54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:a3cad57e-ddd7-4e07-b028-0f4716f0459c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2328","original_object":"UniProtKB:O15554"}
{"id":"1e3d4310-64d5-47bb-828c-39dd350edde1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134994","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:e86cacad-e83d-4ba1-abd8-86b108a3a14f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:514","original_object":"UniProtKB:P23944"}
{"id":"8013aa07-3def-460c-beb6-07b503161432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11950660","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:e397afff-6cf8-458b-89cb-df91f3730cc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6431","original_object":"UniProtKB:Q8TCW9"}
{"id":"647f32a4-e5f3-4d77-930b-2f647c9b855c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4466","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:fc62f9df-ab6a-44ba-b00b-47773d7d7250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:521","original_object":"UniProtKB:P08913"}
{"id":"ee63c1ad-fb94-4bfb-b01b-f0d35a66d4ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82715","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:cd556d17-aeed-4255-91e0-822e736ee33f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7818","original_object":"UniProtKB:Q16539"}
{"id":"7c13eb7d-8e14-4ce3-8dd9-bc2f42c0f53e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:815","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:d3a1f33c-a828-400a-8631-7374a594bbcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:815","original_object":"UniProtKB:P51685"}
{"id":"ac96d2be-dc57-4944-8c6e-c3e0189119d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N5LJ2Z26C","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:ea29b0f6-a3da-4515-ab9a-0919cd644ed6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6977","original_object":"UniProtKB:P23458"}
{"id":"59b40abf-907c-42b9-ada1-9ed0b6ce85b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:5e6d7ee6-696d-4bd6-9981-a184b58391e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P14780"}
{"id":"31cbfc91-46b0-4283-b442-615840f04c42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8453","predicate":"biolink:affects","object":"NCBIGene:4853","sources":[{"id":"urn:uuid:272d4dcf-5d47-4b98-87ab-33b53acaab79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8453","original_object":"UniProtKB:Q04721"}
{"id":"6d36ac15-e847-4486-9c5f-35ef69642bb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86304165","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:a244869e-84d4-4d22-b653-fd11ba688398","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13494","original_object":"UniProtKB:P22607"}
{"id":"b9c2b53c-53e2-4262-8760-352a43730209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:164890","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:33e9f258-51ce-4dbc-a649-c50998c7814e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12424","original_object":"UniProtKB:P59540"}
{"id":"36419668-6469-4a47-b7f8-ee81ffe26049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488758","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:7672e061-5c76-45c0-ac94-aa1b6008e22d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10335","original_object":"UniProtKB:Q13324"}
{"id":"74fe796f-93ce-489a-aee8-f71380a63584","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9807249","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:373d08c4-0466-4764-bc50-71b762627070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2198","original_object":"UniProtKB:P30518"}
{"id":"a7de0123-edc0-461c-ba07-b181388bddda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143117","predicate":"biolink:affects","object":"NCBIGene:2242","sources":[{"id":"urn:uuid:6b100829-6826-4088-9469-8e99240d663c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7476","original_object":"UniProtKB:P07332"}
{"id":"e2be38f0-5d96-416a-ac1a-82711ad9f401","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2582","predicate":"biolink:affects","object":"NCBIGene:65195","sources":[{"id":"urn:uuid:4b0c942b-3f93-4df6-861a-fd3b44f79457","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2582","original_object":"UniProtKB:Q62897"}
{"id":"9ad994cd-2732-4887-951a-28863259baf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4316","sources":[{"id":"urn:uuid:57e24cb0-0203-410f-859d-61cf74968e43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P09237"}
{"id":"3e9b06c5-6cd6-44fd-861e-d6c2bcd0ebe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:0700aa97-9a68-4f82-bad5-b70253831db1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:Q02763"}
{"id":"e03d126b-56ed-4a9b-9f2c-434e4f3069fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190326","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:a0e40eed-cf00-4aab-87e3-7593ca9fed78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:731","original_object":"UniProtKB:P34972"}
{"id":"f5f49a15-c0ac-4ec7-8cf1-09dad7c50174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130482","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:50089fad-1aa8-424c-a8b3-0743ac977a33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1566","original_object":"UniProtKB:P20789"}
{"id":"6314d55f-907f-4e51-95e9-a4a85d0b03df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49848557","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:ce67fd5c-7ef1-4f71-9a30-44c9bdd1c687","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9492","original_object":"UniProtKB:O95977"}
{"id":"880eeeb2-cf0e-42fe-a576-93c64bdcc198","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:851NLB57HQ","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:5739469e-9869-4ff5-89fd-547c520229a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1225","original_object":"UniProtKB:P23975"}
{"id":"1696054a-f497-47c8-8c1f-292aea922084","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16198245","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:5fdfec90-714a-4ba5-901a-1487b0fe61a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1453","original_object":"UniProtKB:O43193"}
{"id":"d5b4ba76-34e3-4d5b-874f-01e4850b28f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321159","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:5d67edb7-75dd-4cf8-be37-d4b0f8cf8e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10156","original_object":"UniProtKB:P23458"}
{"id":"2f312d9d-9746-4f39-af15-bc3e6a81cb37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CKP8AS5W73","predicate":"biolink:affects","object":"NCBIGene:72512","sources":[{"id":"urn:uuid:73c1b261-c718-4b06-b8c0-e1dbdb21bb2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11972","original_object":"UniProtKB:Q3TBT3"}
{"id":"bcb29ec9-774d-4af8-9d29-925d97301e38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2545","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:bbf28ad0-3b8d-4f7a-8a18-c25035053f43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2545","original_object":"UniProtKB:P63142"}
{"id":"3968f987-b655-4c4e-bccd-33710bd9a9c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4FR53SIF3A","predicate":"biolink:affects","object":"NCBIGene:930","sources":[{"id":"urn:uuid:ed68fb59-a61a-40be-87a1-77960a634092","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7384","original_object":"UniProtKB:P15391"}
{"id":"e79c956f-772e-4150-a50f-f3e689da590f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"UniProtKB:Q9NQU5","sources":[{"id":"urn:uuid:d4e2da1b-78ab-411b-af4c-ffe286961627","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q9NQU5"}
{"id":"b46ae815-26b7-4b95-bc12-e7ab87f2d084","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:a5deba71-8eae-4b64-8744-3feb3c86106e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:Q96GD4"}
{"id":"6c704501-9035-48b3-a958-935ae81ecd13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63607","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:f4d4e410-97dd-4d77-b4d6-36564dee46f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10827","original_object":"UniProtKB:P21397"}
{"id":"749adc2e-f072-47ef-bd6a-19b4f62cdcfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83934","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:76557ea7-9cdd-488b-8e41-b24328d7c9b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3073","original_object":"UniProtKB:Q02769"}
{"id":"9642bc8f-4315-4b6f-8343-f9ff08e05c42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71422","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:8504df71-b31d-42a6-a1ed-e856bae1c60e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12452","original_object":"UniProtKB:Q9NYV7"}
{"id":"c9b471a7-3e8c-4a3f-b862-59f38e6dceb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86290500","predicate":"biolink:affects","object":"NCBIGene:2081","sources":[{"id":"urn:uuid:a9ee7b9d-08b6-4a6f-b0b5-fb4000af1438","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8129","original_object":"UniProtKB:O75460"}
{"id":"e066c0ef-a2f7-4d58-9cfc-319208d96b19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91666","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:3d2d6dcb-2212-4d12-8273-fb3c145705f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1650","original_object":"UniProtKB:P33534"}
{"id":"2f0c4ab9-08c5-4c2e-9e61-282f00cbb03e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:518962","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:b762f799-9dd1-4ab0-878d-bab0b3aa1a1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1625","original_object":"UniProtKB:P35372"}
{"id":"196f3fb3-d4db-4863-9e51-b2ab1aa8e70c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46229","predicate":"biolink:affects","object":"NCBIGene:140795","sources":[{"id":"urn:uuid:38a160c9-cd60-4779-a1c3-afb0717e3bc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1783","original_object":"UniProtKB:Q9ESG6"}
{"id":"f427c3d8-1d8f-4135-b08b-15d2d4f6049b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123773279","predicate":"biolink:affects","object":"NCBIGene:29117","sources":[{"id":"urn:uuid:7e7ec21e-f1e0-4e27-8ae1-a6ede7855507","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9522","original_object":"UniProtKB:Q9NPI1"}
{"id":"c4e094cf-62d5-4db0-b332-07b9ee87264c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5T4TX6CO53","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:c53ecf1f-b890-4a87-a77b-5391f2f208db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10736","original_object":"UniProtKB:Q9Y5N1"}
{"id":"f6a44365-c979-46db-a874-4346278942e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:bbef76f5-bf6b-43be-8740-da8ae8738453","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:O88704"}
{"id":"1db862aa-a8ea-4f33-bbb1-e402977c5b27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4F4X42SYQ6","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:2c66442a-ae4c-4af7-914c-11c181d082b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6780","original_object":"UniProtKB:P11836"}
{"id":"0479c59e-6677-48ce-9bb5-738a51d20a75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559100","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:90ebf68a-e2f6-42e0-b334-d0462919b0b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:219","original_object":"UniProtKB:P32305"}
{"id":"c34e96e1-8d71-4800-8f9d-6649bd7b6a3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2618","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:1b0292a5-850c-435c-bb21-45078a6f9dd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4128","original_object":"UniProtKB:Q13224"}
{"id":"29e27e2e-7bc3-44ab-9e4a-fcb4d376151b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:8f26ffda-2070-4ca8-8811-55e8cc730d9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P28335"}
{"id":"9842ad36-fac4-4700-adbe-921f59d8be96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:e3a883e3-2747-4a22-b3ff-5556dd2e65e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:P04629"}
{"id":"15b5bde9-a2ef-4d9e-a248-e45ce4725cc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75170","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:8c56e6b7-4041-463f-90c6-229749c0f54d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3057","original_object":"UniProtKB:P37268"}
{"id":"589f036c-56a2-46cf-aa86-704dd833bffb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:317cc024-be73-44ba-ba68-9071684c350d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:O43497"}
{"id":"aace35d1-8e4d-4a01-a93f-f62569eafb96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3803","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:306b37dc-37d8-41b8-80e3-5b6bde8ed6bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3803","original_object":"UniProtKB:Q96P65"}
{"id":"894805fa-4871-42d0-b9b9-17b94979574a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:119915","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:fe2b1446-2cc3-4af0-b9ac-87a2006fee24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1626","original_object":"UniProtKB:P41143"}
{"id":"414b16eb-a75c-45bc-8704-07452cb100a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132947","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:eadc41ca-2d60-441a-8b16-21cf21b1d167","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:361","original_object":"UniProtKB:P08912"}
{"id":"6d6fdd58-fe70-4a9b-b8a7-9f9732bb692a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:d6379084-89a1-4b2e-b106-acf9eb0e31b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P41586"}
{"id":"c8d8589c-fef1-4a9a-8862-a961c4ab3c53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155801618","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:37e86831-5fe0-49aa-8928-2035afd0e3da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11766","original_object":"UniProtKB:P0DTC1"}
{"id":"73530148-1f2d-428b-ac4d-77293164b017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2567","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:d827c94c-3dae-4b2c-b693-fbc4a0b6dbf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3141","original_object":"UniProtKB:P14324"}
{"id":"bc0641ba-78f7-4e5f-9083-8d6b0e6ebd5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:304e02d1-59dd-4245-8c3d-bad18db8de52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:O88703"}
{"id":"70e67a01-d006-4a8b-9658-26ba42ccddc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118884610","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:e78b634b-72ef-44ec-88a5-4a9ddfe098e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9891","original_object":"UniProtKB:Q9UBN7"}
{"id":"91caafa8-c12f-471c-9160-1aa55ab2ff32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8496","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:c2544af2-6815-408a-b644-2d8faf53f5f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8496","original_object":"UniProtKB:P25024"}
{"id":"6fb21c76-4e43-4d4e-9acc-9fdeeb8e7c81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600335","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:4b4387ed-5930-478e-852b-5abfce32024e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10549","original_object":"UniProtKB:P23458"}
{"id":"b8b99aad-00fd-4d16-a093-67a2e9a01cb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44445","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:d990ea8e-c7b7-4c5d-ab39-8a405d45563a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7401","original_object":"UniProtKB:P35354"}
{"id":"cbeffbe8-6f4d-43a7-a303-a8d5959510af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118165440","predicate":"biolink:affects","object":"NCBIGene:81600","sources":[{"id":"urn:uuid:f321e563-8f41-4856-ae6f-ccfd91cf9f9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9780","original_object":"UniProtKB:Q91XA9"}
{"id":"919f4304-dce7-4aa7-b5df-d2eed546a1df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91517","predicate":"biolink:affects","object":"UniProtKB:P18901","sources":[{"id":"urn:uuid:6031a0b5-f503-4497-a5c4-e7cf41562f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:938","original_object":"UniProtKB:P18901"}
{"id":"ac3fa1ec-3b9c-4d19-b661-ba7f36f7552e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LT369U66CE","predicate":"biolink:affects","object":"NCBIGene:920","sources":[{"id":"urn:uuid:471381ec-74a7-4c3f-912d-5b63ca4c200a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10208","original_object":"UniProtKB:P01730"}
{"id":"e0b138af-77ae-4a1f-9d38-44ee27a0d0a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:e614c1a5-e947-482f-a5d3-a9b5cce941d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P00533"}
{"id":"ded0ff81-4641-47b6-a239-ab8ae1bd4a19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:7819d388-a5c4-4e0f-82d4-8c103bb4c835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P34969"}
{"id":"7951fe05-5e13-44f8-a92f-6e3e181c9de7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79042","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:9a3579d2-e13e-4ce5-aead-b4f9fb19180d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7393","original_object":"UniProtKB:P49286"}
{"id":"da234233-c423-44d3-abf2-4b42301c8131","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:898","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:d2c490dc-bf00-4904-8256-8af6698e77df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:898","original_object":"UniProtKB:P30553"}
{"id":"eeb3de40-a236-4c87-8328-27ea8fcc8e5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76591","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:519229e2-74a4-4768-bc45-e41456985f6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2752","original_object":"UniProtKB:P55055"}
{"id":"454879d7-6681-4fbe-9bec-097fd874869d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121990","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:3668f215-51a0-4f70-92f2-5d59fae903c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1710","original_object":"UniProtKB:Q9H244"}
{"id":"c3bb2b06-6951-485c-b050-44b412f56a1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91666633","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:d2aaa9d2-799a-4287-abcb-4f773f40e7f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10003","original_object":"UniProtKB:Q15858"}
{"id":"ce3a427d-cf2b-48b6-b4fc-9c0537b84f34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:112974","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:d70d9330-e6f0-4ca2-8fb6-0464bed6e9e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5819","original_object":"UniProtKB:P43116"}
{"id":"e0da1c5a-8f35-442a-b649-b26e934472b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072547","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:d80e4dbb-58cf-479e-a050-f878a608de18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8936","original_object":"UniProtKB:Q13177"}
{"id":"c4f8711d-6ac0-45c4-b541-3f0783a1076e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3780","predicate":"biolink:affects","object":"NCBIGene:2492","sources":[{"id":"urn:uuid:8c05acb7-fd40-423b-8002-2a8695581da2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3780","original_object":"UniProtKB:P23945"}
{"id":"45bb074f-19ac-407b-94d5-103a499b5241","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126970682","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:267d85c2-2036-4fb5-8143-7978302be01a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9570","original_object":"UniProtKB:P55085"}
{"id":"21bd3496-4cba-4707-b023-2689a002baaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947044","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:ed43c6c0-c05f-4c9b-8732-50606e53a53a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2982","original_object":"UniProtKB:P51639"}
{"id":"8e41a609-1529-425b-af06-d16ff05bbcf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ERE9QW3XH","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:fabd91d9-86e3-4a67-8d92-44952c13a5f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10662","original_object":"UniProtKB:Q04771"}
{"id":"b38c5739-fd30-44cd-8f5e-5edb4d1804c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:26580","predicate":"biolink:affects","object":"NCBIGene:11309","sources":[{"id":"urn:uuid:3eceeedf-3aa1-4dde-a3eb-8d60588f6a73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4570","original_object":"UniProtKB:O94956"}
{"id":"dc18a6ad-71fc-4bbe-bdf5-4afe5a78b05b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13893","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:67a57059-fc30-47bf-9841-196a85ef5ca5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13893","original_object":"UniProtKB:O14757"}
{"id":"d9970349-6fba-4f78-85b9-1797dc6a97f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78544","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:bfc079d0-c7a7-44da-b457-a98870f46cf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5976","original_object":"UniProtKB:O14965"}
{"id":"ca3742ad-ea64-42c4-baef-0cf408dc1a7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34968","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:5f1f11d5-06b2-4395-8b1b-206a0e61f12b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4197","original_object":"UniProtKB:P48169"}
{"id":"608cd176-dbeb-4302-b5eb-8a8a4b3dc325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13686","predicate":"biolink:affects","object":"NCBIGene:6272","sources":[{"id":"urn:uuid:3c33f21b-79c8-4486-894a-53b08f118503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13686","original_object":"UniProtKB:Q99523"}
{"id":"90e535a3-ffbd-412b-afc4-20e239ab0f98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:ee538c72-bfd2-4722-8495-1302c8c2909e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P04629"}
{"id":"124e2b22-5ce2-47f3-a906-e33aea5e1e12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5026","predicate":"biolink:affects","object":"NCBIGene:779","sources":[{"id":"urn:uuid:d4709697-d48b-44db-807e-1890febbd26a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4318","original_object":"UniProtKB:Q13698"}
{"id":"74f18e0d-65bc-4a7d-a9fd-b11767195ede","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11750118","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:802a5613-519b-4157-b315-7ae78be98774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9253","original_object":"UniProtKB:P35354"}
{"id":"2bc73f77-7498-42e0-b20c-f93f3023d3a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50922","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:4fef22f1-600b-42ff-a0d2-f05c98a4cc17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:40","original_object":"UniProtKB:P28222"}
{"id":"9993501d-105b-45bc-9b0e-836ead80cfd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:116557","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:0b67b361-f6f4-4e1e-b064-8f1dc0038f00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4335","original_object":"UniProtKB:P13569"}
{"id":"902f19d1-eb94-458d-ba75-3aea3165cb4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6103","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:3bd547e0-aafb-4b73-87c5-f7bcbfdbcb6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6103","original_object":"UniProtKB:O60755"}
{"id":"920ca178-8d35-4555-8db4-baca19907963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4149","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:5d3760b0-1482-4599-9a28-fcd4b9e7a163","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4149","original_object":"UniProtKB:Q13936"}
{"id":"b04e8e1b-442e-4755-82d1-29658a49249e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117902000","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:ac8669a9-f806-422e-855e-142fca768212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9964","original_object":"UniProtKB:Q5S007"}
{"id":"c047f8df-19fe-4cbe-891c-ffe7ade935da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9145","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:3be54ac6-1db9-468a-9921-642f8c98c302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9145","original_object":"UniProtKB:Q8NET8"}
{"id":"93becf61-6194-4753-896d-afa2b09503df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64156","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:5c6b0ff5-8e45-4ac4-9aa3-0d85fca6856d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1250","original_object":"UniProtKB:Q9H3N8"}
{"id":"4fb458ab-696b-45d5-abb0-1a458c6e165e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:46BBW2U5D6","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:e9648168-d39f-4c2d-9e7d-87f412713bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11656","original_object":"UniProtKB:P08473"}
{"id":"3e783cda-ec6d-4d2a-9f0c-646dbfc565c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OVW60IDW1D","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:bdb8a445-abc4-4822-806e-d1962ed23325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10096","original_object":"UniProtKB:O00329"}
{"id":"6a3b7215-e5f3-4f3f-9701-d3d1658d5f70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2048","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:cf31fb3c-c9c5-4013-816a-e121c8c396f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2048","original_object":"UniProtKB:P30874"}
{"id":"83b5bcf9-f72e-4857-942d-6af0ad770ea5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3DSH8LL4L","predicate":"biolink:affects","object":"NCBIGene:70536","sources":[{"id":"urn:uuid:534d8b5c-facb-4e5f-8058-8fa2e900a357","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13397","original_object":"UniProtKB:Q9CYK2"}
{"id":"a8f520f2-53f2-4e06-a087-702adf0df436","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24743936","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:81807e09-7519-46f1-8d0b-b38fedd045d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12650","original_object":"UniProtKB:O43526"}
{"id":"abc21836-b5a3-435e-bba4-927bc3558ab5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9957278","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:8662da7b-dcfc-4da2-816f-15080411ccf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1179","original_object":"UniProtKB:P30968"}
{"id":"9514c2da-70d4-48e8-ac95-4721521c32b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73357","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:df484af2-2732-41c4-9464-579f1224600f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1655","original_object":"UniProtKB:P34975"}
{"id":"432541e8-079e-469e-abb8-b02d751e6817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9818466","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:e4ac7b47-226d-4795-8b51-b6b1bb2bf470","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2696","original_object":"UniProtKB:P37231"}
{"id":"047a9fa8-5f2d-4c2c-98d4-06a827151795","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93986","predicate":"biolink:affects","object":"NCBIGene:79813","sources":[{"id":"urn:uuid:b08d5372-8a65-4545-91fd-4b6c1419092a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7014","original_object":"UniProtKB:Q9H9B1"}
{"id":"6afe6901-b86f-40d9-a9df-3f4e5f161032","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925847","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:14e1359a-5a27-410a-a7ff-295e52ee0186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11543","original_object":"UniProtKB:P0DTC1"}
{"id":"528038ff-be43-4d3d-a3f9-295bbdeb31f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91634","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:db989711-ecfd-473c-a051-8c4a242b7b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1613","original_object":"UniProtKB:P32300"}
{"id":"24138fa7-c228-4ae2-b558-d41e6d73d64f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8OO2SLF34L","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:dc0b25f4-8b9d-4cb4-b1a5-a87f197c4471","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5918","original_object":"UniProtKB:P09619"}
{"id":"9ed84d14-32dc-4281-ad25-c4eb6e5fe271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:b7cd2fda-77ba-4d3c-91ef-d332f37da84f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P50406"}
{"id":"0709695e-b49c-4f4e-b32e-9e66fe540f39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:81025","sources":[{"id":"urn:uuid:044d8fde-35c7-4533-8040-44a8ed1775f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P57773"}
{"id":"880a98c5-96ac-4462-9cf1-9ca6b820bf85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122028","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:749f608b-cc4b-4b20-8d78-4433d9f829d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9445","original_object":"UniProtKB:P30542"}
{"id":"e28385fc-8dde-4f33-b4bb-02295662a9fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D5X8A5HWL0","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:1941cdbc-c49a-44e6-848e-27a6e0405ac8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12750","original_object":"UniProtKB:P34913"}
{"id":"8ee88831-b3be-4e71-b563-ad5aa4794f77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31539","predicate":"biolink:affects","object":"NCBIGene:1579","sources":[{"id":"urn:uuid:4783cef1-ce25-4bfe-9ee4-9537637eade4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11371","original_object":"UniProtKB:Q02928"}
{"id":"7552bca0-1c68-478b-97f0-6ace01ff29d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4S4LA22APY","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:acf03a7c-f1f9-4ceb-8e3b-641f0259f9bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2217","original_object":"UniProtKB:P30518"}
{"id":"03aae7dd-e89c-4d40-8412-4eb597be3edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4761298","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:23262dfb-81d4-41e5-a77a-347ab2f1b24c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11600","original_object":"UniProtKB:Q9H2K2"}
{"id":"9bfa02a3-061b-4299-bae2-0105fa994113","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44369","predicate":"biolink:affects","object":"NCBIGene:2548","sources":[{"id":"urn:uuid:a922abd6-2bf0-4bb6-aba7-b0bc65707602","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4642","original_object":"UniProtKB:P10253"}
{"id":"7d3cb25b-639d-40bc-a84a-f42dc7e7be05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2012","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:1d15e0e4-f2bc-4cc5-98e1-319eca6755cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2012","original_object":"UniProtKB:P32745"}
{"id":"8b00898c-d1b9-43b3-9100-302485fbccc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440621","predicate":"biolink:affects","object":"NCBIGene:29310","sources":[{"id":"urn:uuid:1785f433-6518-4c17-98de-5a7c5304d0e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1325","original_object":"UniProtKB:P32244"}
{"id":"2f04aaec-bf58-4848-96d2-bec90ec5ca17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817409","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:dc6738c5-d000-42f4-96b6-58d414830eb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1462","original_object":"UniProtKB:O43193"}
{"id":"fdc6ae65-fc6e-46b7-90b6-deb62f17cdc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3764617","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:a8625452-9291-4746-a2f3-7e5c6d6a39b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10219","original_object":"UniProtKB:Q9NYA1"}
{"id":"1475e6a8-e5c6-429f-956e-1266fcbf7c3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10849065","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:2aa19f23-9ffd-4310-b1e1-8a9e27cb71d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1345","original_object":"UniProtKB:P48039"}
{"id":"dd20262b-8364-4083-9c55-5c5164913c0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138377384","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:30330a10-566e-463b-ae07-d42043adf992","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13107","original_object":"UniProtKB:Q13546"}
{"id":"aa354548-45ba-4bd6-acbc-2db58ec678fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:1aeab7ac-a752-4954-8ebd-0c555f1997a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:Q91ZY1"}
{"id":"f1813dbb-153d-400c-a7fc-6f86e5416ed1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10447834","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:e919cd83-9efa-46e9-9e22-0c2e089719b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4026","original_object":"UniProtKB:P35367"}
{"id":"665e4ac3-187c-464a-b166-258ab4868da9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46186926","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:114c8542-068e-4cd7-9662-c00bfbd56bcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12617","original_object":"UniProtKB:P23443"}
{"id":"5ce8df1c-5e9d-4039-ab04-ef4aad893316","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:04d615c3-86a9-4a29-a1bb-57c191afcccd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P30935"}
{"id":"775b6bb1-8a3d-4b26-92fb-0d60edf569f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:23605a12-4305-4272-88c3-96dc259bfe2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q9BY41"}
{"id":"edd65a0a-e117-4aa3-9ee7-4a17251a4dbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2216","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:9bf3b045-0400-429b-bf0a-a32779c1f2d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2216","original_object":"UniProtKB:P37288"}
{"id":"a9083233-ee80-45f7-aab8-c4fcdb5d64c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1159","predicate":"biolink:affects","object":"NCBIGene:3973","sources":[{"id":"urn:uuid:5c132ae3-5b1e-4d5d-8afc-28b0cc62fc41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1159","original_object":"UniProtKB:P22888"}
{"id":"fa538af8-08a1-4ab8-8bcc-09fa99275ba6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:e5c4e911-5838-4a87-b7f5-f81f0f619b51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:P21453"}
{"id":"9e2b60c1-cc0b-4c3e-88cd-339558e3d6c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151501","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:d2222d41-57dc-4adc-8d53-0e5740ce4358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4097","original_object":"UniProtKB:P35523"}
{"id":"2ff022b7-d135-4132-b3a3-24358144b763","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:ba401703-9e94-458d-af4e-d9f4e97b8e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P28221"}
{"id":"76a40264-c20b-43eb-a499-e4df933c7c87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4I67US2V8Q","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:e2a8ff36-f873-4fc9-9b77-7e053d5412f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9462","original_object":"UniProtKB:P41146"}
{"id":"c4ddda85-8f42-4425-a33b-2684a851e726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:c2076f06-b3e7-4e4f-b9b1-987affd602b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:O96017"}
{"id":"2ae00ead-5c1c-4556-b688-3ea4f0d1d882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54671203","predicate":"biolink:affects","object":"NCBIGene:4316","sources":[{"id":"urn:uuid:68b24391-93bd-4d83-b4d1-ac0156e427aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6464","original_object":"UniProtKB:P09237"}
{"id":"3256cbca-6f0c-453a-92f1-b720bfdcdfdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9987879","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:ca88856b-3559-4479-98de-db9416b76cee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6893","original_object":"UniProtKB:P50052"}
{"id":"8cd88985-0cf6-4a03-8d79-23dbc5250a6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:491f0605-2f11-4942-ac77-bf5c02f81067","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q99500"}
{"id":"334e4a74-4a98-4c77-b739-7a8c3bd39def","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:e5358aa1-e691-44ae-a2c7-0889f044c4f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P30939"}
{"id":"3bd29045-8213-46ba-89f6-118f7f12fc4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:ffca1d5d-255f-4eb0-9e2e-89a3d843711a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P80192"}
{"id":"cbf3df51-c3e0-4bfd-84c0-5dd28a9ef0bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:68667","sources":[{"id":"urn:uuid:e0169887-5ded-47c5-a78a-e63cb58f17a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q7TN37"}
{"id":"9df47698-b1ac-4544-8bf4-54007e8606fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:7371294f-ab22-4f83-b5e4-7f7ce3e68ef4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P16234"}
{"id":"918660b4-fa0f-4cd7-af4a-bfeb77b1363c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4994","predicate":"biolink:affects","object":"NCBIGene:3563","sources":[{"id":"urn:uuid:402c453b-9b41-403a-aec1-75c28b4d9614","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4994","original_object":"UniProtKB:P26951"}
{"id":"dd5ab9ed-31a4-4359-a5c1-863bb78e75a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:94226","sources":[{"id":"urn:uuid:82907497-f7f4-49f6-a9f4-84ce4eff2afd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q91X56"}
{"id":"700b5093-664b-4248-a641-3737c63e9454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28502","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:e458364c-c266-4da3-ab72-3a66c1f1e573","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7310","original_object":"UniProtKB:P18825"}
{"id":"3ed5d45f-ea07-4d7b-b1a3-fe6e96883f40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91832","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:4f55d079-14d4-4f5d-b8ac-2dfd33146039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3285","original_object":"UniProtKB:P30543"}
{"id":"3e862d65-10bd-4e0f-8182-1b7d6b6f439b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68540","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:cbdf1c7e-2098-45d9-bd1b-bc29d2414db7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6844","original_object":"UniProtKB:Q02127"}
{"id":"2f4846a1-456f-455e-9123-c6c149786a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J0035E9FT","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:640b13f7-08d0-4ccf-ae5b-8a4754ab3bc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12754","original_object":"UniProtKB:P34972"}
{"id":"62c88a63-4f88-4d33-9204-fd0c662dda3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:935415","predicate":"biolink:affects","object":"NCBIGene:5927","sources":[{"id":"urn:uuid:c64b3a84-2688-45a9-b9b9-584ecddd1039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7026","original_object":"UniProtKB:P29375"}
{"id":"b1cf701c-a3ba-4e61-a426-c497a814f538","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081971","predicate":"biolink:affects","object":"NCBIGene:834","sources":[{"id":"urn:uuid:b27169c9-728b-4d88-a0ca-003a2f8259f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9901","original_object":"UniProtKB:P29466"}
{"id":"26d83bb5-3083-416a-94b9-6e9e1da42df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7037","predicate":"biolink:affects","object":"NCBIGene:3276","sources":[{"id":"urn:uuid:8d3a5b89-a4a2-421c-8fb8-ca665d934ab1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7037","original_object":"UniProtKB:Q99873"}
{"id":"7952658a-e759-461e-a50e-353c994ff6e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312129","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:66c6464c-a764-43fc-a557-757e11902e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1952","original_object":"UniProtKB:P43114"}
{"id":"a3bb923f-5aaa-446f-b9e5-e66ace7a9306","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:57e85ccb-9a02-4f9d-a21d-9817d43e3a9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P48542"}
{"id":"0ae7353c-5d8f-43c8-96c6-daa73accb718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104895","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:efb4889f-72b3-4e18-982b-5c5e03e52090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:730","original_object":"UniProtKB:Q9Y2T6"}
{"id":"75071f5d-7357-4527-a494-ce0b34d19a72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:c7bed880-48dc-4ae0-b7db-0ce36318a49b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P16234"}
{"id":"e75039d3-d6e7-41c2-ae13-e6fe207ffaee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817422","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:7acc1d43-83a8-405e-add7-fd0ccc8a8997","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1549","original_object":"UniProtKB:Q63447"}
{"id":"5ad710c6-ecb9-4a23-b243-b7c6568a0d16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:820NH671E6","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:a8e16578-f259-4abb-bd4e-4a9e3b5b1d0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9549","original_object":"UniProtKB:O14757"}
{"id":"58da0f8d-e22d-4706-9dd5-77dcece94268","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:aa678e2e-7450-4cad-9de1-55cbc09ba8f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:Q9Y463"}
{"id":"4f1066dc-9419-44d6-8b15-d383686f3ad4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71283262","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:0d9f5e7b-085c-4f1b-b2fa-4f6da18bcbfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10498","original_object":"UniProtKB:O75116"}
{"id":"36bd8e6d-7a03-4b38-9fe8-855697ee966f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78549","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:e5896a8c-be42-4be7-9a2d-f7926a5c12bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:92","original_object":"UniProtKB:P28222"}
{"id":"42374d1c-cb74-4c2f-8593-c4b2de57fe62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:1259","sources":[{"id":"urn:uuid:996a6bcd-1063-4481-9cb1-b0e32edce4b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:P29973"}
{"id":"c5cbf0a3-8da9-47f2-8f46-bebb564abc0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:ff1f4784-ce4e-40d1-b7db-ab163bcb11d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P21917"}
{"id":"b688b166-74f4-45c1-99fa-8845b5af46a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:041850a5-7835-4fd4-b8ac-7f45a530d5ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:Q12791"}
{"id":"2db72a5f-adc0-401e-9eb4-c3dc468ac199","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433297","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:bcfc16ac-667d-4ecd-9df3-99b5ddc35f63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12726","original_object":"UniProtKB:P42866"}
{"id":"c17a68e5-2647-4b00-812b-4222da31480d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4KW1M48SHS","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:0feb91fd-f222-4fd4-905f-7739a436f44a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7733","original_object":"UniProtKB:P98170"}
{"id":"f0e2aa00-c404-4413-a161-f3e7c416ac7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:0a2f6995-bcee-4ac4-a6ef-c174e59c4ddb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P50406"}
{"id":"7a7a49a4-7942-41c0-b344-e193fb21560e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0UPX3E69W8","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:a2b7f74b-cd25-4a94-9a32-6afc1223d528","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8370","original_object":"UniProtKB:P21918"}
{"id":"22aa869e-1dde-4be6-b195-e9e7abd91527","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145499","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:35e834fb-4912-4043-b584-691f8b8081ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6599","original_object":"UniProtKB:P22303"}
{"id":"4d7372a7-833e-4121-ba44-dd9bd3a45439","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340639","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:f104679f-6d52-41f4-a13e-b3a058aadeb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4283","original_object":"UniProtKB:P34972"}
{"id":"70b2d473-a9f0-4fc4-864c-3828d4428757","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:7b2aa675-45f4-4ac3-9820-e3a6c1d60265","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"b6d9c0d7-9fdd-4ca8-bf23-56775f32c406","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755145","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:dad637e4-ee42-4af1-898b-18f25199a421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5712","original_object":"UniProtKB:P11362"}
{"id":"a4c47ef2-95cd-4361-92cb-dedb6fd1c1b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80308","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:cf410e5a-da66-419a-a853-3018fb1bc997","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2098","original_object":"UniProtKB:P29371"}
{"id":"90ce10cc-9bd0-45fe-8a45-a1c74b9310f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76400","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:270f2b7c-d398-4d80-ad4c-1b79c3bf8a9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1192","original_object":"UniProtKB:P30968"}
{"id":"03af5790-ba0f-4ce8-9364-789b3e5cfe34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68181876","predicate":"biolink:affects","object":"NCBIGene:57144","sources":[{"id":"urn:uuid:2717023d-1cb8-4373-8432-088b196b41f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8941","original_object":"UniProtKB:Q9P286"}
{"id":"93e8761e-23c5-457d-abee-1951ddeaa91a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:119915","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:b81466e4-fc9a-4760-bd34-7832b39a255c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1626","original_object":"UniProtKB:P33535"}
{"id":"4d375f4c-3fbc-4fb3-9d37-a851327033aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL413188","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:4f528498-f173-46be-a065-5c9b371bbbcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5991","original_object":"UniProtKB:O14757"}
{"id":"0ab29b79-c77b-4851-9cbc-ea849fff1d92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6251","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:6184af23-667c-43c1-a483-7f0d306da041","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6251","original_object":"UniProtKB:P25090"}
{"id":"ce9f8f26-5220-44cb-bcaf-c00a0f507748","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:91a20808-9f5a-4100-83df-d3f21f80e741","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P42866"}
{"id":"550998bf-4b68-4149-bebb-64f730526c4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435286","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:6f85f7ce-0df1-41a3-9508-6d38e001b4d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3353","original_object":"UniProtKB:P25090"}
{"id":"c6cf21fc-6fac-4f96-8e02-aafa607613b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6K8WSV73A","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:3c63d16f-7b7f-4cf8-9aef-3ad82985d4ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10707","original_object":"UniProtKB:P21589"}
{"id":"6f53fa1d-70e7-4e40-93d9-1552a5a744db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6113","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:bf6201b2-78ee-4a73-bfcf-d97a07aa86ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6113","original_object":"UniProtKB:P47211"}
{"id":"eaffa6a1-cfd0-442b-80aa-ea916a417182","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6954180","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:453b72c2-f112-4c71-8b76-407608acbbb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:286","original_object":"UniProtKB:P08172"}
{"id":"b9f7cde1-a0ee-4de9-a601-2c8c72602ff6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107633","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:de4867ca-6851-40a4-a783-47d3bc1dc0fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4323","original_object":"UniProtKB:P23979"}
{"id":"b171cadc-64b5-407e-bdb1-f7a86523a590","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Q9O54P0H7","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:1692cd33-11af-4543-bd19-f6a35121bfd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6193","original_object":"UniProtKB:Q9Y271"}
{"id":"069dd14e-1634-4d57-9ba3-5cb622c03e87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14372618","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:02319193-0470-48aa-acb7-6914476121a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9878","original_object":"UniProtKB:Q07343"}
{"id":"ef86a8bb-d985-4b49-bd9d-cb1487b968d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:6344","sources":[{"id":"urn:uuid:4a2ef4e4-ded5-4892-b76f-fdca7ac1fc73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P47872"}
{"id":"6b6bca61-f45e-42b2-81a0-4342b261cd76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:0cfb0120-17ed-4584-b565-57796cecca9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P28221"}
{"id":"db398d40-398a-453f-920d-ed25f147602f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138179","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:8555687c-581d-4cbd-9fed-7b7aa2ac8896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6239","original_object":"UniProtKB:Q8NET8"}
{"id":"8f2f24de-ea3d-445b-82ca-1f3e44d11a48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194135","predicate":"biolink:affects","object":"NCBIGene:50835","sources":[{"id":"urn:uuid:66d50f4e-d00c-45b3-ab1a-f11874a66f78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10918","original_object":"UniProtKB:Q9NYW1"}
{"id":"4c591046-938b-472e-8b92-fd1df5d04dd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1561","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:facf3011-dce7-43a4-bdaa-6255465f585a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1561","original_object":"UniProtKB:Q15761"}
{"id":"9615df01-f77a-4227-aefb-84f496e81b62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2264067","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:28d4c50c-01c7-4c3d-9680-e5203afca9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10038","original_object":"UniProtKB:Q8TD43"}
{"id":"e1b4ef24-5b88-4e5d-86cc-37e5d37ead20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488874","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:3b705681-a839-4e56-b56f-0b7e359b11d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9188","original_object":"UniProtKB:P21554"}
{"id":"a15253b8-b257-432e-a58d-424fecf48a82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BIB7HG2V9E","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:f53e8b6c-5958-488c-80b9-b0b470413c2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6501","original_object":"UniProtKB:P08473"}
{"id":"c4eb32b1-adb9-4d7f-8822-ca682b8e6e98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:420K487FSG","predicate":"biolink:affects","object":"NCBIGene:3566","sources":[{"id":"urn:uuid:67cd83b8-081a-4761-9e09-01214037b8b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7574","original_object":"UniProtKB:P24394"}
{"id":"c076c901-74aa-48ff-bbc7-003f2eed3213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24763119","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:9fa5b74e-2f62-462f-b67f-aa9d7028b945","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6416","original_object":"UniProtKB:P41594"}
{"id":"cb73bc52-3a67-43e7-ad58-4d06686726d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10271","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:7be980e4-c71a-4f39-a69f-a487121bfc83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10271","original_object":"UniProtKB:Q96RI0"}
{"id":"68e0cc4b-7d68-40d5-a20e-aa3000e6d32f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139299","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:e7542570-9531-433d-beed-af4f67a18685","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2500","original_object":"UniProtKB:Q9EPK8"}
{"id":"c782589c-c4cc-4fd6-8441-67f9132a23df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44132853","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:713120d0-7631-4f1a-af3e-7900d2f43f41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9814","original_object":"UniProtKB:P12931"}
{"id":"d7388328-bded-4cd2-ac67-cd0b8ab17a54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:59ec1bb1-2da7-4882-91d9-a22b8398f417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P30939"}
{"id":"b72ade7b-2817-4feb-a835-2bb5ec90e401","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:9c51434b-3365-4aa2-a061-0f4ef2532748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:P70604"}
{"id":"2a6d309b-0149-4e29-ae3d-abe6881a712c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9927967","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:8a9f92a1-cd08-4d5c-bb88-2eab076a24b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7735","original_object":"UniProtKB:Q99705"}
{"id":"58ddc41b-7b2c-4672-a2da-5dba264bc7e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11417","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:8341cc4f-d0c8-4b66-ab89-bcb011047df2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11417","original_object":"UniProtKB:O43603"}
{"id":"dd4034d3-5027-46f0-8161-972808bd1373","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:70a77e8f-1067-44ca-9b64-7848caaf240b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q8BLA8"}
{"id":"7c51601c-42ab-4af1-a732-eff422512bb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YKQ241VJ92","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:6c5500fc-8596-43d6-bfd1-9033f6e849cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5689","original_object":"UniProtKB:P36888"}
{"id":"800f9190-f61d-4f1a-9a85-9f697077b36e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117807031","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:19fe37bc-19c5-41f4-a168-d64edcb35c53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13203","original_object":"UniProtKB:P04049"}
{"id":"92850afb-f72e-4365-b0d2-8f2f7ed1b0a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94513","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:fdb4cd1d-0eb5-4da5-8cd0-f85487d5872a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6828","original_object":"UniProtKB:P22748"}
{"id":"92190bda-1f67-4e0d-a6c3-4a5285b1ded4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7872","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:44553cc3-8425-46c8-94bb-4362d5abe1b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2174","original_object":"UniProtKB:P47901"}
{"id":"562e1525-9585-430e-8ba7-9c3360dcd8e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135005","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:d99f78ad-79da-413b-919c-321ff48acfcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7436","original_object":"UniProtKB:P23975"}
{"id":"15b5b8d9-e8ba-431d-ab3d-cf8344e0f742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:f4e3c878-66b2-494a-8bec-1c51588a093d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P50406"}
{"id":"e3d71f81-38c4-45ef-a0e2-161f5bbd180c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:53373","sources":[{"id":"urn:uuid:3cbefdc2-2238-4bc6-a105-5fe819fb6f31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q9ULQ1"}
{"id":"33c7d448-b08c-47bb-8dfd-7f0fc4719602","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134296695","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:4444f20f-26fa-402e-9937-7706e11a2828","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12491","original_object":"UniProtKB:P55085"}
{"id":"9051a333-62d2-4207-a7f0-639223979c85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168429725","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:1160c0c4-2e59-42e1-a872-2d2eab45e16b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13383","original_object":"UniProtKB:P43220"}
{"id":"c19d5b0a-705a-4dee-95fe-40e03dbb86ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2705","sources":[{"id":"urn:uuid:cd78f8eb-2769-48a2-a329-2f88baa5f4a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P08034"}
{"id":"74f61197-4266-46b2-aae5-c1670c2ea836","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1575","predicate":"biolink:affects","object":"NCBIGene:64636","sources":[{"id":"urn:uuid:40aed8ed-fd53-491f-83b7-b99e3b82383e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1575","original_object":"UniProtKB:Q63384"}
{"id":"a1ee58db-9d22-4100-9331-9ec5d2cbf1c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136034","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:67db3371-5682-4aad-ae19-d2951f252097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1324","original_object":"UniProtKB:P33032"}
{"id":"53e24b4e-f28a-4ed7-92d0-bc236fedfbfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76IND1BS43","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:f3665854-2f74-4038-ba07-16ee31ef935a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4154","original_object":"UniProtKB:Q14957"}
{"id":"6b7c3254-02e2-4c9c-9a70-38eb9e30d451","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947026","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:ebcddff4-67fd-47fc-a8fc-b527dc2375d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3004","original_object":"UniProtKB:P04035"}
{"id":"c62d727a-1653-4c6a-8d02-c054225a2c05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189669","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:c6264fca-0354-4f44-ac8c-9b06523ce8ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13549","original_object":"UniProtKB:P28223"}
{"id":"662ce881-6217-48c8-9fb1-a72fbbb8f5ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121596705","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4288b980-3348-4547-9e35-be2003dda4da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9286","original_object":"UniProtKB:P35372"}
{"id":"c6565433-bc08-4ea0-b628-33c338433c9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:67c40aae-bb86-47c6-b800-1d60768849e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P31388"}
{"id":"b18b113d-df42-46a2-800b-d0704b4842a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:664510","predicate":"biolink:affects","object":"NCBIGene:246","sources":[{"id":"urn:uuid:a86826c7-08d7-4ea9-aaec-61ed83a63686","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10263","original_object":"UniProtKB:P16050"}
{"id":"7b31fd37-1778-40cd-badd-42a8591bea95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2185","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:ed446430-be8b-471a-8fc6-1d863ad5099e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2185","original_object":"UniProtKB:P30518"}
{"id":"d84cc9a4-5916-4f06-9a08-3791ee313ddb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:d528cf63-2a05-42d2-b4ac-5d207de57af7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P23385"}
{"id":"f7456271-2fab-4139-ad5a-719c1dd50238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:9beff3d0-68af-4c2f-956f-f09445cfe168","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:Q62805"}
{"id":"84fadb96-15e0-411e-8591-59ca5b2680ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:522609","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:f47edb17-6e85-4839-a486-def0ec6723d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:282","original_object":"UniProtKB:P32304"}
{"id":"09d914b2-7c57-4977-aefe-0944d5ef6afe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9952446","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:8f2af4b8-5a17-48c3-86e1-e2aed7630eeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4251","original_object":"UniProtKB:P42261"}
{"id":"bda8ba9f-8eb4-4c52-bedc-03276446d7cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:520985","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:54900374-644e-4b79-9fc9-07ad4f7a82d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7110","original_object":"UniProtKB:P28221"}
{"id":"a6bb8623-1962-4433-815e-e544dd5e9dcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3965","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:1fee3b5a-366e-4621-b814-212ce7fa4a0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3965","original_object":"UniProtKB:P36544"}
{"id":"bd4de324-e0a6-4b98-8722-7d6049633e54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5262","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:607ec688-f705-4066-be6a-88e510af35aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:410","original_object":"UniProtKB:Q9UL62"}
{"id":"42d3c769-c5cc-4728-a817-691b5691aef0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41872","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:fc2218cc-57e3-4b88-8f73-43130a09e716","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2313","original_object":"UniProtKB:P70604"}
{"id":"9a59bd7a-4dcc-4252-bb85-7750bcc7c610","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90929","predicate":"biolink:affects","object":"NCBIGene:116085","sources":[{"id":"urn:uuid:3df8a109-bd51-423f-8805-9f3462f72095","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7673","original_object":"UniProtKB:Q96S37"}
{"id":"896f5fdc-a940-418c-8b2d-68019df3f862","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81724","predicate":"biolink:affects","object":"NCBIGene:40","sources":[{"id":"urn:uuid:6db5d258-9d54-4486-b919-bb258cdeff4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10307","original_object":"UniProtKB:Q16515"}
{"id":"50279e29-67bc-4fad-ae43-f8c7bb8d95cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:789Q85GA8P","predicate":"biolink:affects","object":"NCBIGene:3417","sources":[{"id":"urn:uuid:4d5674cc-dd92-4f6b-b619-65c9fe167e6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10663","original_object":"UniProtKB:O75874"}
{"id":"0880a9d0-04e8-43cd-b39a-056a64f680b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C88817F47Y","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:73b00c82-6219-4591-bb63-6d7e8bc85184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8918","original_object":"UniProtKB:O00329"}
{"id":"8c0fe39a-50e6-42e6-aff4-665b1c6c630d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9805","predicate":"biolink:affects","object":"NCBIGene:4162","sources":[{"id":"urn:uuid:eb5ba889-219b-4f0d-8054-e54e6f350bbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9805","original_object":"UniProtKB:P43121"}
{"id":"1ad8abe4-07f1-4b7c-a605-7471d177eba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O5CSC6WH1T","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:ec738c7f-f00f-4a72-a489-dcc315799f98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9234","original_object":"UniProtKB:P21554"}
{"id":"f90c92bd-f58d-4718-86e8-f1f22e4162d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8925","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:cd2dd00f-45ae-4340-8da3-d67f58b53964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4303","original_object":"UniProtKB:P21817"}
{"id":"fde3427d-a82e-415e-95fc-a75a2d58ae68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:54a6c5a0-37ef-4727-84a8-4b8af1b727bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P28222"}
{"id":"1d7fa385-e126-4929-89b2-264b3cdfd236","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1338","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:be9eb891-be33-4177-8ec2-9f0d534ffdad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6600","original_object":"UniProtKB:P22303"}
{"id":"99a17bbb-8ca0-4ba7-812b-afbbf496e0f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34558","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:5ea6320a-51f2-487d-91e4-9d968d41aa5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4145","original_object":"UniProtKB:Q9P0L9"}
{"id":"a3a7cf72-2eba-45f5-82fa-18ed7c11a9b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:6176d12a-24d1-46c1-bd88-cfb94365b2d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q9Z2J6"}
{"id":"3991c452-a2cb-4add-84d2-7a21afe60672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947033","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:dcb64abf-1e9d-4ebb-891f-3b9c534afdaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2997","original_object":"UniProtKB:P51639"}
{"id":"eaf68124-dc52-4927-83a9-e4d5300631f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5RV7T5BNMG","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:92c6a7dd-7f28-41a8-be7c-e561079fd8bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8984","original_object":"UniProtKB:Q9H3N8"}
{"id":"5ae42d5f-717c-4c44-b6ab-c2d10d795976","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134817174","predicate":"biolink:affects","object":"NCBIGene:8644","sources":[{"id":"urn:uuid:1359c8bd-e99a-4cbd-b175-079e75f680df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10262","original_object":"UniProtKB:P42330"}
{"id":"48ab7822-6b01-4250-8066-98ee5d4e2210","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190826","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:c990c1c7-daaa-4012-bc87-c554fc55162c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13468","original_object":"UniProtKB:Q08499"}
{"id":"c1fbcbcb-6803-418d-897b-b5a0f142f3a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:3c9bc2a9-6861-4bda-881b-1154faa01c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P28566"}
{"id":"f4212b7e-89c0-4877-9ec7-a113fa3b6256","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:209845","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:7074da18-2692-447b-bb39-a24b27b7c57a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6128","original_object":"UniProtKB:P47211"}
{"id":"019c8e88-fdd7-4567-8f3e-8ca8dff16379","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123973","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:9e06746a-2f26-42fd-afc5-c5e02b15463d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:675","original_object":"UniProtKB:P30411"}
{"id":"3b3db256-2e71-4189-b00e-368168a56093","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6100","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:60d27bae-4197-46fc-9933-c1c5c08f058d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6100","original_object":"UniProtKB:P47211"}
{"id":"ae5ef952-59e5-4642-bc97-31f70c158d30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231414","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:73a0c91a-0f4b-4627-b570-8f3f03df368a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9230","original_object":"UniProtKB:Q08345"}
{"id":"05b52b89-f167-40a3-b0ff-d096f0c09038","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134301","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:fce2c2e3-d691-4b04-b023-a2a8c290affb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13515","original_object":"UniProtKB:P09619"}
{"id":"3a1c7126-a63e-43dc-b44d-3ab2373e0792","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24754886","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:1697a598-cb08-4907-b798-9537ef9bc3a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8855","original_object":"UniProtKB:P98170"}
{"id":"a855ec77-b757-4541-9dad-8a1d24acb05a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146273261","predicate":"biolink:affects","object":"NCBIGene:23387","sources":[{"id":"urn:uuid:fc4a8b7e-2339-419d-98c0-fc2bc78675bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12157","original_object":"UniProtKB:Q9Y2K2"}
{"id":"e8df44c3-7c3d-44ec-b203-eccce3df8245","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6221","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:0ec81afb-c4ba-409e-99ea-2ca4d76ac4d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6221","original_object":"UniProtKB:P31422"}
{"id":"82704c3a-6810-4432-a4c3-fe0dc8c151d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2610","predicate":"biolink:affects","object":"NCBIGene:116745","sources":[{"id":"urn:uuid:b7873cda-9cee-44bd-8a89-a7147e58d6c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2610","original_object":"UniProtKB:O54853"}
{"id":"a7ad81b4-13ba-4dd7-b7b8-09ba5b2c6beb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44365677","predicate":"biolink:affects","object":"NCBIGene:5644","sources":[{"id":"urn:uuid:c7faceaa-5c20-4f9d-ba68-df50e14e21b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8559","original_object":"UniProtKB:P07477"}
{"id":"e17b575d-3b95-4d0c-8651-41e106d80f9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50922","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:65ba4093-075c-4e1b-aeb7-21c22d909a2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:40","original_object":"UniProtKB:P30939"}
{"id":"3fe4ac08-b991-4820-abd2-5ea9b43539b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93369","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:e041bdf4-4650-4b59-b70a-989e76ec2827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:85","original_object":"UniProtKB:P35367"}
{"id":"78498e27-6e18-4094-b4da-06338b1bacbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2697","sources":[{"id":"urn:uuid:e1a8d340-8e4a-4336-b9a2-d622e9cfc97e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P17302"}
{"id":"b6d309ce-f16b-4120-ae1c-b45216b093e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072556","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:29dbe87d-f275-4973-ac58-9c95c88c9096","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8999","original_object":"UniProtKB:P35354"}
{"id":"d7b815f6-f6a3-4405-bd84-09c0bebfec3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"UniProtKB:P52189","sources":[{"id":"urn:uuid:207a2350-4e70-416b-9002-04846b6cd974","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P52189"}
{"id":"4dc52e11-a0c0-4859-aa29-854a3b768db1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1658","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:e7d337d5-1d5d-4b88-85b4-374845f687d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1658","original_object":"UniProtKB:P33534"}
{"id":"9a5841da-1b9d-4e90-ba14-0f06af161ed4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:032c559b-79b0-4dda-88d4-42a033888dda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P28221"}
{"id":"54e43af4-b3ad-4fe6-8618-ff4fed620686","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138628908","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:0c87c69b-cb2d-41bb-82da-37008a5bf660","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11888","original_object":"UniProtKB:Q04771"}
{"id":"7f9ba9ca-f3be-4f79-9f89-258033a89672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129165016","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:f6451d26-7ce3-4c53-a2dd-19b1939f7a24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12350","original_object":"UniProtKB:P23458"}
{"id":"1c806d38-cf8e-4d24-9987-2b507d3ad442","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70479","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:ee0b6ee7-3010-42a8-9ee0-6b095143cee7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2462","original_object":"UniProtKB:Q8R4D5"}
{"id":"875f7346-3904-4a0a-ba15-c6c9a64c482b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827341","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:dc5764e3-80a0-41c2-ad87-3fd72d86dac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1726","original_object":"UniProtKB:P47900"}
{"id":"167bfb1f-2bb4-4f16-b28b-7a93b66a0a78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:38a22eaf-6a3e-403b-884b-a03cdf78ded8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:O88854"}
{"id":"f473f8db-fa5a-4545-a404-6abc915c47aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:9c72f1cb-a848-4070-83b5-8371acc5eda4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:Q17ST2"}
{"id":"f0bed9f6-2217-4f21-9598-0528df28dd68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KL2Z2TLF01","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:11bd7b71-5b00-4d41-957a-056d117ff952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5933","original_object":"UniProtKB:O60674"}
{"id":"96a48eb2-ce93-4cc3-a1fb-f9cafede4233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11649","predicate":"biolink:affects","object":"NCBIGene:29851","sources":[{"id":"urn:uuid:aaae7f24-63f6-46d0-a073-c297af9ca55a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11649","original_object":"UniProtKB:Q9Y6W8"}
{"id":"854da549-9f11-4128-872c-fe9fb9caadeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34649","predicate":"biolink:affects","object":"NCBIGene:57582","sources":[{"id":"urn:uuid:ddc97472-a0fe-4573-9bcc-b23e4eed8ea7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2507","original_object":"UniProtKB:Q5JUK3"}
{"id":"a5369221-0632-47d9-afc0-1386a24b1952","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134764","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:84d8ce71-cfd9-4fbc-98e0-cce5457cbccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:299","original_object":"UniProtKB:P08173"}
{"id":"7766dc01-a876-43f9-8193-2a5b961242d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76072859","predicate":"biolink:affects","object":"NCBIGene:9943","sources":[{"id":"urn:uuid:bc3b84a9-1fc0-4fe2-b867-c3177dec42e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8219","original_object":"UniProtKB:O95747"}
{"id":"7c5b6fba-af30-4921-b24b-d475023a53f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755077","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:a0689398-ebf0-4669-995e-d89db15f2a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4102","original_object":"UniProtKB:Q13002"}
{"id":"acc7f46a-1309-4561-bfaa-9b6f0abce986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71200","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:d36785e8-6ad5-4558-b462-2301f3dcaddc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5677","original_object":"UniProtKB:P52333"}
{"id":"963b5498-ad8d-4a49-a9ec-7596b79f6e8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:61f779d6-5495-4721-813f-8c41b6b179a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:P52333"}
{"id":"d91927fe-71ff-4ad8-a673-cd913391c1ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GN429E725A","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:3dd1b8dc-3ba6-46bd-a9af-fbfcab3841ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9766","original_object":"UniProtKB:P78527"}
{"id":"3796e257-50ee-4f3e-a44d-f49c502f893e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175443","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:a748524a-67c4-442a-81ad-877647c76734","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12422","original_object":"UniProtKB:Q9NYW7"}
{"id":"1e3f24ca-b9c1-45f5-ae15-1f6066b27318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80308","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:81621456-36d4-4331-9e1b-3dad9c84a84d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2098","original_object":"UniProtKB:P21452"}
{"id":"10a59b56-7f8d-496e-9b95-b68b0e49cd33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31527","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:112e7d71-cfda-4b4e-bef5-33b927574c7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2878","original_object":"UniProtKB:P06401"}
{"id":"ed915b1d-15b0-45ba-80db-c966fc61b652","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:c722ebd4-1e56-4939-b5c1-a2617c8050fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:Q02156"}
{"id":"a58fdd7d-3a31-42e0-a0b2-34a22e4ae548","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:eb299c44-c683-410a-91e6-9798bdd33b2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q14957"}
{"id":"1f984b89-5fce-45fa-9b76-d82bc6036afb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91666633","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:457db631-c359-462e-b179-4aa15e9baf99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10003","original_object":"UniProtKB:Q14524"}
{"id":"2b4aebcb-9ef3-4cd2-85a6-3b281411325d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3037456","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:c4df7efe-fa77-45ce-b048-287e4363b9cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:78","original_object":"UniProtKB:P08908"}
{"id":"e2a9f2b9-cfbc-40b7-a26b-d18139ef7bf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9614","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:2947fcb2-8c5c-4589-bd5d-c9a650fd1a20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9614","original_object":"UniProtKB:P47871"}
{"id":"ad3d7666-11a8-42fd-ba75-7eb1e981f73a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:4565805c-6f91-4327-9859-ef00615e5250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:P47211"}
{"id":"a2d68de8-f16a-4d91-8bbe-0d0a96fa060c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:75d0a88c-89d4-41c2-afd1-a6ee0c2df306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P50406"}
{"id":"bd309588-ea2a-4e68-b104-d32a3b6e8913","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:169876","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:e8038d48-8225-4981-a8e1-6f9825a5445b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10204","original_object":"UniProtKB:Q92731"}
{"id":"1a96d197-6f58-4486-92be-1949c077a803","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393292","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:b97eccfc-ee7d-4609-a0df-3d0197291b67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10400","original_object":"UniProtKB:Q9Y233"}
{"id":"1d119276-fe9e-4440-af7c-1d99e331a6b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23648296","predicate":"biolink:affects","object":"NCBIGene:1508","sources":[{"id":"urn:uuid:8441c9d1-0317-4f9f-bf2c-510247ce421d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9298","original_object":"UniProtKB:P07858"}
{"id":"4476d620-f4a0-4192-8b35-d068461df7f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086682","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:9a3aa1f0-d9cd-4d1e-9f67-f0401f59e69f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2123","original_object":"UniProtKB:P21452"}
{"id":"2b71184a-4ef2-4d80-8a7d-dc1413047271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4A2Y23XK11","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:bab940de-003d-45e3-a89d-6600581f1563","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10136","original_object":"UniProtKB:P35968"}
{"id":"b42e0996-d16f-4a2a-bf38-d0155d347a9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1514","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:1d48f824-2b91-47e9-baed-e007ad71c080","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1514","original_object":"UniProtKB:Q63447"}
{"id":"bcd149ff-1a86-441f-a539-961602560bdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LMQ24G57E9","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:2b33a3b2-36f5-4672-8235-c18b370c1f28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11648","original_object":"UniProtKB:P56719"}
{"id":"47b61688-878e-43ba-bd18-c16baf412936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611898","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:a16145b4-40a9-4557-be82-a5a5d8356503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10002","original_object":"UniProtKB:Q9Y271"}
{"id":"6959072a-5de4-439f-9478-4e3272c7c185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44658","predicate":"biolink:affects","object":"NCBIGene:5515","sources":[{"id":"urn:uuid:a128d743-fade-479a-96bf-9400b1979a5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5349","original_object":"UniProtKB:P67775"}
{"id":"b44bd7b4-7d2a-4ac9-844d-69e4c3ead9e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587557","predicate":"biolink:affects","object":"NCBIGene:10892","sources":[{"id":"urn:uuid:a122aaed-e344-45af-9088-bc00f5164ce1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11589","original_object":"UniProtKB:Q9UDY8"}
{"id":"86473487-babb-487e-bb9b-f7f8a1152a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:22848","sources":[{"id":"urn:uuid:fd2ef79d-29bc-450f-ba0e-1214c464cbc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:Q2M2I8"}
{"id":"68216f48-ac47-4dbf-9dc4-864ccc921a28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92180","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:543f6804-38ca-4ddb-a7e0-4958e522fef4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5620","original_object":"UniProtKB:Q60614"}
{"id":"fbf5f424-02e3-4c99-9bc0-e9012396bf65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8077","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:fa50e949-385a-4144-b3aa-f55f34e1563b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7268","original_object":"UniProtKB:P25100"}
{"id":"bc2ba852-e553-43c4-a018-10766674bdeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1484","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:d2c03a4f-6132-4b83-a689-a2cc249b05bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1484","original_object":"UniProtKB:Q9GZQ6"}
{"id":"13661aa9-49f1-4e0e-b337-2b58a103046a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10192854","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:00f99565-3fc5-45d0-943b-7820550720c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1421","original_object":"UniProtKB:P41594"}
{"id":"076e7a3c-fee4-49a7-920f-5d01f04ca614","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:389898","predicate":"biolink:affects","object":"NCBIGene:1326","sources":[{"id":"urn:uuid:26477372-5964-4f0c-a84d-bbc1ac44e126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6007","original_object":"UniProtKB:P41279"}
{"id":"b6baf815-8331-4c19-9e4c-4e6f1d7e84be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2547","predicate":"biolink:affects","object":"NCBIGene:3737","sources":[{"id":"urn:uuid:10ea5900-1685-48be-8b39-b953a18c563f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2547","original_object":"UniProtKB:P16389"}
{"id":"4b59e8f1-fce4-4c76-b6c0-165947738da9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:138ce72c-f78c-4960-9701-4957252dd822","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P18089"}
{"id":"d397f021-9514-4347-a5c7-81c0959d0c46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:e23b5e68-2eef-45df-bc77-572a26c4f988","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P28223"}
{"id":"f35d299a-72a0-48be-bc41-7b95cbe32506","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:ab2b149f-e792-4c16-8aa7-2d8939e0bf6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:Q14416"}
{"id":"1d200ef9-8029-4e31-9bfb-1301876d832f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312367","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:37702284-c1bb-4a03-b70c-58847dded892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12353","original_object":"UniProtKB:Q15910"}
{"id":"7f31ecab-b4cf-4c24-9c0e-697eb1c5f7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71451488","predicate":"biolink:affects","object":"NCBIGene:29843","sources":[{"id":"urn:uuid:669cf45b-b8c2-4f0e-af29-1ac915b34099","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8780","original_object":"UniProtKB:Q9P0U3"}
{"id":"ed519036-76dc-404d-be67-48965b60d175","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:181d9313-7ebb-458b-b7c4-78340677facd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:P35408"}
{"id":"dd03302e-bc1d-4456-ad19-a63c04de29b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118556943","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:4ebcb2d5-19f3-48a9-a26a-add46681b56c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10365","original_object":"UniProtKB:P42336"}
{"id":"7170092d-c4db-4429-9bb7-1c9794a45983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GWS86V23Q8","predicate":"biolink:affects","object":"NCBIGene:774","sources":[{"id":"urn:uuid:5caebe3e-6616-471d-a39e-2fb2108573a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7766","original_object":"UniProtKB:Q00975"}
{"id":"c880264e-45ed-4b4a-8170-1f57edee6134","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91359","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:b78bb3b4-972f-4964-92ed-d3d54ba9908c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8059","original_object":"UniProtKB:P42336"}
{"id":"f80d3617-7baa-4433-8443-9ff7c23eba4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119517","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:c3e32fff-02e8-4332-9205-72774cd4ad00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2225","original_object":"UniProtKB:P30518"}
{"id":"97a36cea-9163-4768-8f29-be3d3b02f0c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91346","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:e41f49da-9015-4a58-8e6c-48c627e1f41c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5921","original_object":"UniProtKB:Q9Y243"}
{"id":"f4bb0905-0fb8-45ce-a9db-e2d677e1e0f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:20183","sources":[{"id":"urn:uuid:7e2307bd-116d-46b1-86c3-1125e1294e13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5383","original_object":"UniProtKB:P28705"}
{"id":"bb7947a9-f597-490a-b3a6-172bc2da3964","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1327","predicate":"biolink:affects","object":"NCBIGene:4158","sources":[{"id":"urn:uuid:688afcf5-b16e-434d-a013-3afc183b9fba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1327","original_object":"UniProtKB:Q01718"}
{"id":"22835e11-4776-4025-9a9e-d0f809ce817c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:39c50bb5-2a65-41cc-9998-58d7b82c0ae7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08485"}
{"id":"2cb33635-dfb6-4d7b-8002-a908b67b0e74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813899","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:3d4af38e-e42c-4e3b-a69f-858e6af36f00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9438","original_object":"UniProtKB:P49684"}
{"id":"0336154d-2833-4c45-a646-b08f033de6b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:9049a642-4621-4860-a1a5-2ac4a7ca6f7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P41595"}
{"id":"7ae0701a-566a-421d-84c6-243d4afd623b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73337","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:1ec85ae6-181c-4395-879e-62ae8599e029","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1236","original_object":"UniProtKB:Q91ZY2"}
{"id":"67973689-01ae-4808-925f-2338ab851f91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:de79271c-972a-4441-ace1-2fb08ac41904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P00519"}
{"id":"b6365556-3b3a-4a87-9d68-4559a2d8cbaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:e9afe09f-b782-468a-85f1-97fbdcd5dad9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q13547"}
{"id":"ab203846-24e2-4a51-ac93-97f9ba9243fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817504","predicate":"biolink:affects","object":"NCBIGene:5046","sources":[{"id":"urn:uuid:dad9a496-be4a-4838-9ff8-2cbe9de73ac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8648","original_object":"UniProtKB:P29122"}
{"id":"137f9c36-b88d-40d7-a8c4-bedd2e2119eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9793868","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:91381e8a-1fc4-40dd-b3d8-4e32f7cdfb69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1252","original_object":"UniProtKB:Q9Y5N1"}
{"id":"c3d50f2f-95ea-46d6-864e-4ac65ac98c28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321153","predicate":"biolink:affects","object":"NCBIGene:5927","sources":[{"id":"urn:uuid:6231357a-7723-4090-972b-5e9dcc7bb3a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10141","original_object":"UniProtKB:P29375"}
{"id":"8c3df268-d322-4a13-8138-90a57c238a70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82698","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:aaa902b8-7ec6-4b1e-89bf-19e6d9206cbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2890","original_object":"UniProtKB:P56718"}
{"id":"11657200-1230-4e37-9674-d8aef2fffb82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10344307","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:9cc906b4-6cf3-48e2-a070-0530b7e850b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8629","original_object":"UniProtKB:P45452"}
{"id":"66439e97-aedb-4625-9a5d-8fec808965c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3875","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:31ffebff-2594-405c-946a-91b4007203e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3875","original_object":"UniProtKB:Q8WXD0"}
{"id":"77b24ebd-3b17-44e4-987e-e38f7cc99a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2006","predicate":"biolink:affects","object":"NCBIGene:25033","sources":[{"id":"urn:uuid:d4f3f470-fa6d-458f-b4db-4edb96b85171","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2006","original_object":"UniProtKB:P28646"}
{"id":"60cd7b44-d26d-426b-8482-3914987070e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68649","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:af38392d-1d9c-434f-adc7-b685cc1c8263","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2169","original_object":"UniProtKB:P30559"}
{"id":"222dde55-9c9c-4fa5-be4e-f7aa18da0d63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2697","sources":[{"id":"urn:uuid:15fc5685-5f9c-4559-9546-3eb454eebc04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P17302"}
{"id":"50b06c18-c09d-46ce-a84a-9c9fea0d43fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604758","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:e50b6a71-a070-4273-99bc-170a72644f34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:951","original_object":"UniProtKB:P14416"}
{"id":"bf7940a2-15f1-4db5-913a-389a6c0f7567","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135411610","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:28f04a73-4be6-49e8-8340-057db3480c57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6228","original_object":"UniProtKB:Q14833"}
{"id":"ed2f4a1a-c904-486b-9a90-8cebaf81d2f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:92YDM6122J","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:fdc0cf55-309e-460f-8c30-30daaf6f7306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6996","original_object":"UniProtKB:Q99500"}
{"id":"006e6dfb-14da-406f-8f6b-822bf5e8d4ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ERE9QW3XH","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:4f75cb8c-b422-48c0-a05e-ad186abbae43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10662","original_object":"UniProtKB:P36897"}
{"id":"0de917ff-27df-477d-877d-6a9de04353ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5782","predicate":"biolink:affects","object":"NCBIGene:24808","sources":[{"id":"urn:uuid:751aa6df-2180-4dd5-876c-1864a80fc46e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5782","original_object":"UniProtKB:P16177"}
{"id":"0ef157b4-757b-49b4-ba85-138c1b567da5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10849065","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:e208b7a8-2079-45e0-a69c-0e84340505e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1345","original_object":"UniProtKB:P49286"}
{"id":"8ddb0cf8-4394-492a-b5c9-212bcf50dbee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:d5465c78-a47b-4034-8e49-8b6a2602d328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:P25021"}
{"id":"6d1f4390-e74d-417c-8092-1a893a2f3a2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LQ52UF48A","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:1bdc0319-4e4b-42ad-855e-dfa4aeb372db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5945","original_object":"UniProtKB:P06493"}
{"id":"6d66dfae-3bad-42f0-a954-e4b5903b9179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030535","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:c0ae13ce-359d-424d-b3e7-a15014de5cf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10489","original_object":"UniProtKB:P42336"}
{"id":"4b2e6c67-5d3a-49f3-883f-59498ca2b308","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S052TOI9BI","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:c5075b6d-68a6-4c80-bf8e-c511d24e6c17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5757","original_object":"UniProtKB:P25103"}
{"id":"36892628-454b-40ea-9844-6c3342e435bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46945265","predicate":"biolink:affects","object":"NCBIGene:1591","sources":[{"id":"urn:uuid:acf5513f-969d-429a-a1c1-2a48a047234d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8852","original_object":"UniProtKB:Q07973"}
{"id":"44035108-f52d-4700-a75d-d9f9850020a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:5138","sources":[{"id":"urn:uuid:f7ec0e86-b34f-4ce0-b223-bcdb7795329e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:O00408"}
{"id":"8e747ee5-3c8e-45da-b866-edb4c8f17ee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122189279","predicate":"biolink:affects","object":"NCBIGene:8493","sources":[{"id":"urn:uuid:b0532224-c29c-4927-b857-250cd2cb4e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11104","original_object":"UniProtKB:O15297"}
{"id":"2906b81c-f26f-4cb4-b184-1ae1bf49740d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135926","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:6072fc34-c0ce-4ecf-b6ba-7d7ad3965fcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11577","original_object":"UniProtKB:O76074"}
{"id":"32de13e5-608f-48ad-9259-882e9e58b74c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11675630","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:bd35e490-7bc0-41f8-9fae-459a2cc03ba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:6376","original_object":"UniProtKB:Q8R455"}
{"id":"91b2b082-0398-4c73-8b79-8d38cd417563","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94644","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:84c2ecc9-8245-4187-abb7-b87884ce71fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8068","original_object":"UniProtKB:P12931"}
{"id":"11d34428-05c6-4d9c-9527-aa9860c1e2b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:6c96b58b-dc8f-4786-913a-00254c105374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:Q9UGM1"}
{"id":"95fd4be4-af8d-4a0b-8445-b4d5c89df432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34649","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:acd1f4c7-d8ef-41d1-b30f-0d37b31593e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2507","original_object":"UniProtKB:P22460"}
{"id":"192640e7-dfd9-4904-b109-1e2618452d3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4284721","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:cb5918d7-a912-41c8-9c1e-06d982b7a014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:248","original_object":"UniProtKB:Q13639"}
{"id":"04632362-4790-4e34-b343-d80875db818f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25102784","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:83c8e041-3e88-4e90-83c4-73f921330edc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2944","original_object":"UniProtKB:P70605"}
{"id":"5d55999b-d672-471e-8214-41349fae49ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JUA77QEU32","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:9e7f5290-db0e-4be0-8b61-1c356d4b27c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:272","original_object":"UniProtKB:P31388"}
{"id":"56103ca3-c1a5-4576-b2a2-32089a1fcfd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1513","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:2fac5bad-73ee-4abc-b230-6fb2a6e2f7d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1513","original_object":"UniProtKB:Q61041"}
{"id":"32e15252-2a24-4ea2-bb36-1630af2e6643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:38cbf71d-fb27-4538-b17a-23d5a8040dec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P19020"}
{"id":"8e2521e6-1f45-4494-90d0-64cc3f281070","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:41dd774f-36c3-44a6-8d47-d7e1e2de7ecb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P0DMS8"}
{"id":"a39d769b-aecc-48ee-8719-64ae5a5cdd4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755056","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:8e3f39c8-be19-4397-9450-7987f3b5220c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3479","original_object":"UniProtKB:P25101"}
{"id":"a1dadf5d-0848-4667-b958-2ecc4ea3f808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1513","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:e6557db2-2588-41d4-9b86-3e909099c446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1513","original_object":"UniProtKB:Q63447"}
{"id":"962cccb1-b910-446c-b1b5-1e1f8b51df94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2615","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:b05cdf56-feed-41ea-9fa1-aa0991f74426","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2615","original_object":"UniProtKB:Q14524"}
{"id":"bde9b963-e27d-46d3-871f-f5eb7b37f727","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:107810","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:08652158-2c83-499b-80d4-70f01efa8ce3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:998","original_object":"UniProtKB:P25101"}
{"id":"e043b354-fd27-47cc-94df-a4d0b2b2d5bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146277756","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:6e3afa9d-6ed0-46bc-917f-5d630b080331","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12881","original_object":"UniProtKB:Q00534"}
{"id":"2234aa88-a7ac-4488-84f4-4abc70f25f9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3661","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:5118b0a8-d5b6-47ba-85f7-bf4ae2c3b7ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3661","original_object":"UniProtKB:P49682"}
{"id":"b9a9fc5a-899b-4f08-b202-0afaf353a3da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91936970","predicate":"biolink:affects","object":"NCBIGene:6416","sources":[{"id":"urn:uuid:386e474b-7662-4b65-bec6-c8782350ea14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9989","original_object":"UniProtKB:P45985"}
{"id":"f6f95764-d566-4a4e-a05c-ff286d635aeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44577753","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:42f060bb-ac42-4aad-8adc-6391984cae70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8121","original_object":"UniProtKB:Q04771"}
{"id":"c786bd5b-9d57-491c-8eb9-f47619a07382","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44392752","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:5b2ca292-a869-4ce9-98cc-8d8c2708cca4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2908","original_object":"UniProtKB:Q9UBY5"}
{"id":"9d458a6e-2a90-483d-886c-fb88e41bc7a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449744","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:f0a67398-010e-4c8f-879b-ba293606faaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:500","original_object":"UniProtKB:P35368"}
{"id":"0ef200b3-fc90-4583-89b3-d5642a666418","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91379","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:5481ce7c-bad8-4c9e-ae70-8133b1ce838c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9271","original_object":"UniProtKB:P33981"}
{"id":"056054d4-5382-4892-824a-6161d6a5ac24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:8184b212-5d2e-429c-9af9-2cdf9fbe9612","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q9BPV8"}
{"id":"650e5677-088f-4b2d-9311-d7fa5f326d1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134824567","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:e867726b-425d-499f-ac06-004e1034c2a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1301","original_object":"UniProtKB:Q969V1"}
{"id":"cf75d85d-b2a7-4136-993b-94e0c3d9f982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2700","sources":[{"id":"urn:uuid:a0091846-7435-4973-aa2b-8840c52d7e0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q9Y6H8"}
{"id":"4da8decb-3b69-4acd-a12f-0ab94084389e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92286","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:2d0ef2a2-8aa2-4a4b-86fc-5713021606b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13432","original_object":"UniProtKB:P25103"}
{"id":"75b9fec5-8df4-4b71-bb2b-aa5f6fff26d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118522534","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:73d88400-fe40-4bae-aeca-1971c94b1eef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12318","original_object":"UniProtKB:P52333"}
{"id":"ab61a121-fb71-48a7-a541-1fd9586818ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45409","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:26e6e72e-72b9-4211-93dd-979db2649337","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8804","original_object":"UniProtKB:Q9NYW2"}
{"id":"8b966419-7488-4b37-8b94-2d02a500d068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91421","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:f063b26f-89ae-476f-b3ce-5930d3e24213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8015","original_object":"UniProtKB:P49840"}
{"id":"6bba0097-0b14-4009-bdc4-0a7ec39e17cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801155","predicate":"biolink:affects","object":"NCBIGene:290","sources":[{"id":"urn:uuid:998b0132-bf08-4bac-9297-5e60a0349c91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9669","original_object":"UniProtKB:P15144"}
{"id":"4f9caaf0-d3ff-4ab2-9f0e-26c18f84523e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93259","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:89f92846-100d-486b-ac9f-4f3e0d5c3fc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1050","original_object":"UniProtKB:O14842"}
{"id":"550a3685-a26c-4a1f-9764-3fbcea052b52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131173","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:1f679d7d-4f3f-4a7e-bd7e-edc40f0d0177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8069","original_object":"UniProtKB:P16234"}
{"id":"4ad22f28-5bb4-43f1-8000-31c8dedb4237","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4162724","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:db8d3c1d-8a91-46ce-b7ad-299cecb459ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7819","original_object":"UniProtKB:P49841"}
{"id":"45414657-2905-4e51-9c93-e5210b80e44d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129140","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:e8ab307f-613c-479e-85c0-2d084579d773","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8583","original_object":"UniProtKB:P20309"}
{"id":"2dba0589-ca27-4319-8522-9124d9ef560a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76317442","predicate":"biolink:affects","object":"NCBIGene:27443","sources":[{"id":"urn:uuid:019d45d2-4119-437d-ac15-2dfb3c82f161","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8824","original_object":"UniProtKB:Q9BXF3"}
{"id":"531e881f-f698-420b-8ca9-6b328fe01d7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M6RN4LQ25S","predicate":"biolink:affects","object":"NCBIGene:80122","sources":[{"id":"urn:uuid:f92d2f47-b15f-45e6-b419-0c30c167e2c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11178","original_object":"UniProtKB:Q56UN5"}
{"id":"1b983504-0a3b-4a9c-9fcc-cd961d1da6e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2261HH611H","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:5d6d786d-0553-48f7-818b-816a81ba31b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9907","original_object":"UniProtKB:P42336"}
{"id":"38e9efd6-adb7-4bed-a120-4c16f33bc1dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71654771","predicate":"biolink:affects","object":"NCBIGene:22933","sources":[{"id":"urn:uuid:60dfaa38-828f-4229-9a83-335d15212fa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8778","original_object":"UniProtKB:Q8IXJ6"}
{"id":"740317c2-8f1a-447f-af74-fa929f4c686c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N7T15V1FUY","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:e5ebfa10-e105-454c-9cef-9d5cd6d433c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9272","original_object":"UniProtKB:Q01726"}
{"id":"73804d5d-3bbe-4a7f-90c6-6e604c3191b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10578170","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:2568270c-91df-4125-801b-11bb8f5c912d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1097","original_object":"UniProtKB:Q92847"}
{"id":"260bdada-f65f-4089-a8a5-04d2d58595cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2701","sources":[{"id":"urn:uuid:5457f302-3ed6-491f-a986-b5c36ee266a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P35212"}
{"id":"be68bf72-6ed7-4c1b-b694-3a4e56b813d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3548","predicate":"biolink:affects","object":"NCBIGene:8323","sources":[{"id":"urn:uuid:41706fb4-e181-41af-87e1-a1879b099cef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3548","original_object":"UniProtKB:O60353"}
{"id":"b6c5f3ca-a270-4c84-823d-6ad4663ab41c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11757797","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:e05daa64-a0ea-4b7f-9927-bbbfb78806bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:292","original_object":"UniProtKB:P08172"}
{"id":"e11a455e-54bd-40db-a259-4c65fe7e3d55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D848RA61B","predicate":"biolink:affects","object":"NCBIGene:2690","sources":[{"id":"urn:uuid:99b4961e-c844-4896-8042-fb668751f48f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12013","original_object":"UniProtKB:P10912"}
{"id":"ef977779-f9ce-4fb6-9304-2e9fe5f4c9a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118197428","predicate":"biolink:affects","object":"NCBIGene:10803","sources":[{"id":"urn:uuid:423cbac4-960e-4cd4-828c-a8e3e83da5a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9252","original_object":"UniProtKB:P51686"}
{"id":"8680a669-c7d9-4fd8-ad9a-195cd5d5c8ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8113","predicate":"biolink:affects","object":"NCBIGene:115584","sources":[{"id":"urn:uuid:07f9d0de-24c3-4176-8e25-156ea98af08e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4757","original_object":"UniProtKB:Q8WWX8"}
{"id":"51682213-99d7-4288-bf39-f5f013a50da3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:8f7f18b6-31bc-47b6-8eaa-cbd1802e5b0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:P35346"}
{"id":"6c9a54ab-5bcb-403d-8379-ebfd23f9eb68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3964633","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:4c296274-3bb2-4904-b37f-49fe5982f9f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1398","original_object":"UniProtKB:P70579"}
{"id":"dd4ad5df-1f24-40e3-95e9-d292096e27d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167669","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:1caca005-1c13-404c-872c-e6ea32683c8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11163","original_object":"UniProtKB:Q02127"}
{"id":"fd87f549-4f58-495f-80b8-b0edd74f8225","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75124305","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:31e2f83c-7957-4fd9-8dd7-635f9cdeda0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7522","original_object":"UniProtKB:P25440"}
{"id":"34717138-de74-4723-9bfb-26d985551459","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2048","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:cdc72822-238c-47fd-8d55-42dfc1ce2e8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2048","original_object":"UniProtKB:P30875"}
{"id":"555e9294-1a2f-4d7f-85df-f2593b753d7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755019","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:ebd45779-6661-4195-8005-8f5312f25312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1845","original_object":"UniProtKB:Q62035"}
{"id":"10e75cc1-cb26-41a1-a345-c2c48f1862b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LH1ZTY91OR","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:7219177d-b33f-433b-8e66-207ffc6578c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11781","original_object":"UniProtKB:Q07817"}
{"id":"4182fc5a-4034-48b8-b8d7-248d0527599b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR9ZYH80Z8","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:d6158765-e5bd-46c5-8925-9e864ae17a94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9787","original_object":"UniProtKB:P21802"}
{"id":"9aa8e9cb-5e49-48d2-866b-18b01cb76cc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10188","predicate":"biolink:affects","object":"NCBIGene:360","sources":[{"id":"urn:uuid:4d6158f3-5ee7-4611-8b17-ad50d71b4abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10188","original_object":"UniProtKB:Q92482"}
{"id":"0d0f04b7-326e-478a-9d7e-5217d538d523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13576","predicate":"biolink:affects","object":"NCBIGene:5153","sources":[{"id":"urn:uuid:139e553a-67db-49a5-827f-e91e31bd1d56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13576","original_object":"UniProtKB:Q01064"}
{"id":"1483d868-7946-448e-8e3a-b3378a32d27b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2254","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:681cfcf7-a376-4dcc-93f5-c78905df16ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2254","original_object":"UniProtKB:P30559"}
{"id":"4b2bbcf6-554a-412e-9996-844d0e6a51f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2686","predicate":"biolink:affects","object":"NCBIGene:5140","sources":[{"id":"urn:uuid:8f43f5b3-4aae-4381-8e1f-95f83104a4df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7202","original_object":"UniProtKB:Q13370"}
{"id":"7c040df0-9d10-441a-9829-1c6b4e9cd3fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122192250","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:d89d7ba1-5bf5-498c-9e91-1182c40de0f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10277","original_object":"UniProtKB:O43613"}
{"id":"86a86995-9de5-4a7d-8c75-4f181222009b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233330","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:7e561d48-81c1-41e8-a48c-00c196fca3fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2335","original_object":"UniProtKB:Q9H2S1"}
{"id":"1fe14b6f-a1ba-4fef-903d-ec71d13343df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53380924","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:a27dfd22-b96a-4959-a17e-dc9c47e506ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6407","original_object":"UniProtKB:P31424"}
{"id":"2c648a0b-7fc9-4919-b11b-47214f3545d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:74Z5ZL2KVG","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:d9bd5f29-1271-4bff-89d6-449e6aaadaab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9479","original_object":"UniProtKB:P47871"}
{"id":"4a5f8249-1288-4af1-8a39-eacc8c69726c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190251","predicate":"biolink:affects","object":"NCBIGene:22171","sources":[{"id":"urn:uuid:380290ec-febd-42af-8aaa-ebf33436b025","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9590","original_object":"UniProtKB:P07607"}
{"id":"9e6b860a-a6f2-4c28-97fe-bb202e5da5a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:442","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:d744ce24-fae6-4798-aea6-5346fa2a65d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:442","original_object":"UniProtKB:P29275"}
{"id":"fb5d351f-27ca-48e5-8d5b-04b495ec204a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233291","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:a4f99851-90a4-411b-9695-26e0b6e7cef3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2111","original_object":"UniProtKB:P25103"}
{"id":"7847b12b-9788-4254-9b88-51c35972f7c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56658139","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:1edc1505-6e19-45cb-849c-2b2c8c58037e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8551","original_object":"UniProtKB:Q86TI2"}
{"id":"93bbc0b5-b87e-47ca-a61f-fdeb557f372e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1335","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:69445362-f3fd-412a-8e59-f4e72a94fbd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1335","original_object":"UniProtKB:P32245"}
{"id":"efa1ec40-cd75-4a9c-b5e6-225dabfae176","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30805","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:e699794c-4b4a-4648-9f6c-f416731a4410","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5534","original_object":"UniProtKB:Q9NQS5"}
{"id":"3c433152-3e9d-4827-8c23-4430c6e923d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311116","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:463338b0-627c-4138-97dc-a5e4dbce7851","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:544","original_object":"UniProtKB:P07550"}
{"id":"f6d1ed86-9f3d-4931-a40b-23575e984266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194339","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:23f09c2c-4d26-4f85-873c-8e1050a65853","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7718","original_object":"UniProtKB:Q9P0X4"}
{"id":"a06d235f-4519-4542-8944-e3b8acddea13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54760053","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:3a35a4e6-5d94-4ff9-9c0f-4775b03fd36b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8095","original_object":"UniProtKB:P07333"}
{"id":"ba1404d0-ca38-419b-8e02-e8ef835cd5e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:47279808","predicate":"biolink:affects","object":"NCBIGene:55811","sources":[{"id":"urn:uuid:1d296b14-1b5e-41e2-a37a-300b52eaa5d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10023","original_object":"UniProtKB:Q96PN6"}
{"id":"c35846d8-c4e9-411a-836e-c0633bb544f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:8fd9e53b-cc14-467d-87aa-e8ea141123fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:O75311"}
{"id":"46664f52-c1b3-40b4-8d80-5d35b0da3382","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993635","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:3351a461-4c85-4447-969f-d9bdf8d41d50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12334","original_object":"UniProtKB:P45984"}
{"id":"6abc352b-89d6-432f-9c01-1372cc757be3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996538","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:bf5d84c7-2f46-41fc-addb-0372062ad1cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10672","original_object":"UniProtKB:Q9UGN5"}
{"id":"d530f8f9-c767-408d-a2d3-336092b30a2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63618","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:f9bad14e-bdf5-4ff4-9e6a-9aad520f98e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2953","original_object":"UniProtKB:P04035"}
{"id":"8cee4068-ca72-4e32-bd54-aee3401c7800","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16469","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:08dada07-7440-40da-97dd-1e0ffbd6d69f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1013","original_object":"UniProtKB:Q7Z2H8"}
{"id":"4d3bffc6-2050-4dff-ad19-51b4673fe6df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91450","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:cf5a6d5c-00fc-4d67-b945-dcaa2e4fccbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7933","original_object":"UniProtKB:P42345"}
{"id":"86be10a9-60ad-4d63-82b6-61d5ecc57739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:234248D0HH","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:1e35628c-6a0d-4377-b576-fbbd653d2e3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9922","original_object":"UniProtKB:Q15303"}
{"id":"c45edb98-3380-4fc8-bc14-ea84e14037ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:53949","sources":[{"id":"urn:uuid:38badcc0-4c32-4bcb-9f7d-7ea0ed7eb82c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08911"}
{"id":"e261f0ea-7b4e-4bdd-bcf3-f3664cc55a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:6415649a-40e0-4f45-b01a-df63d90953ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P28223"}
{"id":"24788877-1eb5-4ad9-ada7-08793aed40c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71305058","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:739b96c8-6903-4d0a-89c3-3af71ffbe3af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6944","original_object":"UniProtKB:P56817"}
{"id":"10b18301-58fe-46e4-aeb3-93368e52a91a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:0e2c467f-9bfc-4021-94c1-949b0c10efe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:O75311"}
{"id":"665a7462-4bf9-41ed-985e-30d3d68e0289","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13421","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:56b02edd-a3e9-4f0d-9163-d246ee2ff21d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13421","original_object":"UniProtKB:Q96P20"}
{"id":"9cfea4ef-4a3e-46d7-9e3a-455b0f968b1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:22Z53X5LHF","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:1c05ed11-0ee8-4691-b22e-5d5704c548f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10632","original_object":"UniProtKB:Q04771"}
{"id":"b2e45ea7-27d9-49e0-9993-f0c5b5547f39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53320668","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:16bfa4b1-c839-44bb-82c9-a1d46caac3f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1966","original_object":"UniProtKB:P43119"}
{"id":"215d5750-3f7d-4e86-8bcc-5b715c482eaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16610","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:18ff91ad-a87a-443b-aa8e-d33f81321948","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2390","original_object":"UniProtKB:P48050"}
{"id":"57025d73-79f4-4ed7-8acd-cf4c0d8cf5ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168012916","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:a147a613-51a4-4011-a844-dddfa28d95d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5450","original_object":"UniProtKB:Q92633"}
{"id":"2043552f-64b1-4bca-b78c-14ecf07638be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25053598","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:afa9ba44-e1b0-4b2f-9251-f99b536bdce1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10066","original_object":"UniProtKB:Q02156"}
{"id":"71f6b4fb-624d-4dac-8eaf-99bd01a5e30e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45409","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:66a51c65-c6be-46bb-acfd-449bba158fbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8804","original_object":"UniProtKB:P08684"}
{"id":"93cd87ab-4e84-4d25-a387-b9abf657a042","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4B115V09LB","predicate":"biolink:affects","object":"NCBIGene:6403","sources":[{"id":"urn:uuid:9931ddf4-c954-4aaf-b49d-4ad9c21b6d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8307","original_object":"UniProtKB:P16109"}
{"id":"a78748ac-1605-4a9d-af9c-4cffbf75a68f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:0f4e8d7a-9ce5-43ad-b9a5-694963b43115","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P32304"}
{"id":"1fdf494b-ab6e-45c9-8d04-b75efde44b96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232381","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:b0e88855-f425-4a32-84a4-598fe771d4f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9355","original_object":"UniProtKB:P80192"}
{"id":"9ce68447-0af7-47b5-a131-9601b12231e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827383","predicate":"biolink:affects","object":"NCBIGene:29028","sources":[{"id":"urn:uuid:e4d1c9d4-6e7a-46ac-848f-78084054e77e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8640","original_object":"UniProtKB:Q6PL18"}
{"id":"ef738b40-f13d-4a17-8060-586988d77672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1KUR4BN70F","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:0a616146-687a-4d8c-b525-236370b48755","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11329","original_object":"UniProtKB:P0DTC2"}
{"id":"8cfc7195-e477-4fee-9e5d-b22d2fdb13bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66603863","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:2154b063-be07-4895-b094-ac33ac6957b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9238","original_object":"UniProtKB:P33981"}
{"id":"a0008690-9f62-4ef5-be99-8eaaf630b0d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:6bad2062-a5e9-429a-98e7-d346e8aa5937","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P26255"}
{"id":"3976a79f-57fe-4374-87e9-d8dd17cbf1e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:a0d26e65-35da-4db7-a504-3eb77f1f50d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P28221"}
{"id":"2a3fe4e8-10bf-469c-9f88-e2c7a6278b63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46930997","predicate":"biolink:affects","object":"NCBIGene:4170","sources":[{"id":"urn:uuid:7d3d17a9-8f0e-4231-b0bd-e7db73a25cfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11086","original_object":"UniProtKB:Q07820"}
{"id":"d18c5447-46b1-4ebc-a6f6-c19345d23b15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80312","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:3c27c2ee-ed0e-453b-ae1a-ef00896dcd1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2090","original_object":"UniProtKB:P21452"}
{"id":"771cb52e-ccd4-40d7-9969-e7ff596bc075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10259168","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:eb943ed1-3e1f-46ff-bf00-c30cf0a71080","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1446","original_object":"UniProtKB:O43193"}
{"id":"f488f150-c85f-4ea9-bb8a-69c846ff3a6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311384","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:20b20a10-c4c3-45fc-8712-221382effe10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1971","original_object":"UniProtKB:P21731"}
{"id":"e5733f27-85a6-4038-adb1-9eb71a96eafe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3701","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:b65673bf-70ea-4d8a-a45a-677e66c8c20f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12555","original_object":"UniProtKB:Q9HBA0"}
{"id":"e986b047-2458-4e29-9f6d-8d1618a2b4ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:95fa8cb8-feb7-4373-9333-d911ee65b310","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:Q16620"}
{"id":"6aecb99e-b051-4661-90a8-a6ec15bd2f3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27690","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:cec2785b-ad79-4e23-912d-8ea420a23687","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6792","original_object":"UniProtKB:P43166"}
{"id":"74c4d7a9-c376-48ab-a33b-4f02cec8fbbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:619101","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:958b61a0-954b-4fd7-a09e-85dba69cfc68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1148","original_object":"UniProtKB:P47871"}
{"id":"8eb40f38-dd03-4a5f-bc14-2d524ce88683","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35003","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:b00423db-c92d-4ba9-b5c4-3414baf69eae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4068","original_object":"UniProtKB:Q13224"}
{"id":"f43abdd0-0350-4a66-a22a-e1f68b40d3e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:cc9012ba-edee-4b33-9a57-e66879707a12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:Q9HCF6"}
{"id":"fd3992b6-6c11-4eed-aa81-3b9bd0899403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91668547","predicate":"biolink:affects","object":"NCBIGene:55170","sources":[{"id":"urn:uuid:8cc70218-39eb-470c-81b4-a861d1223179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9243","original_object":"UniProtKB:Q96LA8"}
{"id":"191d47c7-7ebb-4f53-a42b-831e9b6b3ba8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926514","predicate":"biolink:affects","object":"NCBIGene:1195","sources":[{"id":"urn:uuid:14d9b6ca-863e-4baa-9b99-df643858c2f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8162","original_object":"UniProtKB:P49759"}
{"id":"a2469c0b-98b3-4435-8695-2456aad3ccb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75377","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:9784809d-b1cb-47b4-a818-9d503ceac438","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2284","original_object":"UniProtKB:P23979"}
{"id":"a9c27f22-46e8-403c-b029-19dc7159b908","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7686S50JAH","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:13d0b0fe-51ea-44d7-86cc-af1493846de3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7443","original_object":"UniProtKB:Q02156"}
{"id":"ea76a2a2-6db1-41a9-af65-67fa7a7ae21e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2943","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:662bed5f-ef89-48b4-a14a-eb3c2543a8f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2943","original_object":"UniProtKB:P23811"}
{"id":"3e5666da-8982-454a-a61e-cbdae236959d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71662429","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:cbc9f60e-28f3-4ef3-9268-453a83776319","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8748","original_object":"UniProtKB:P04798"}
{"id":"acd19b2d-3900-4d57-a4bd-1189d7cd8c77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Y869C2THE","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:5b2b5b92-29d6-4107-b4dd-11da787e0c93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9850","original_object":"UniProtKB:P23219"}
{"id":"0ea17511-9933-4645-98b2-f51ce5758490","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67531324","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:3dc3ae5e-6b90-4c7a-aa08-19e3bd7b6b1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13392","original_object":"UniProtKB:Q13002"}
{"id":"aadbc213-974e-46dc-a659-2a6893ef993e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:26580","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:f9232632-122a-4b79-a1e9-ac79b6364226","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4570","original_object":"UniProtKB:Q9Y6L6"}
{"id":"aa3bd5c4-b79e-4d83-9c8d-80e8960618b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:4058","sources":[{"id":"urn:uuid:dea91d87-d06e-4e84-9345-7e402547c42c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:P29376"}
{"id":"f79c89ea-afeb-4206-9ecb-da9a253c899d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15428","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:9a21fffe-21c8-4110-80a8-55619044843f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:727","original_object":"UniProtKB:Q05586"}
{"id":"35381ac6-5a15-489f-8a39-691ceb2a88c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131788","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:4a64ddc1-d6c5-4bab-920a-26339facf029","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1363","original_object":"UniProtKB:P49286"}
{"id":"bbb0b242-a8f5-44b3-9167-f63f4c5c0e14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35056","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:66b3ed1d-33d5-425c-888d-62d8fb80b1e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4093","original_object":"UniProtKB:Q99571"}
{"id":"1e1b32f2-5472-4811-8668-192896f15ec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79699","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:a818585c-a8aa-4f52-9393-c7f7305ad286","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5892","original_object":"UniProtKB:P42345"}
{"id":"9b305e7c-a04b-4911-b6bb-c0403f7e7f02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167686","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:c3480c53-d3fc-41b9-a032-f89fe29faede","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5671","original_object":"UniProtKB:P35968"}
{"id":"7aecfe88-64b3-413f-9525-609c0a4e7b3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10282223","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:d9128454-bc7b-4687-af40-77f0ea9ccf3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2909","original_object":"UniProtKB:Q9UBY5"}
{"id":"b101adb6-180a-4642-b765-51166e92bf26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:5322","sources":[{"id":"urn:uuid:2846336d-9187-4f74-b707-3f9da752141d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:P39877"}
{"id":"193011c1-ee3f-44fb-adfd-dfa58a7fc515","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:64ONO62P28","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:02f5ff4a-c5be-407d-8dee-87c50dd17bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9303","original_object":"UniProtKB:O43613"}
{"id":"8fdf579a-1347-4a8c-85c1-1812ab4642af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4324257","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:171d3d8e-a7ef-49e0-ac27-c5b8ba9f969d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4080","original_object":"UniProtKB:Q14957"}
{"id":"f4d40fb1-2454-4af3-a8ca-9b9598a95661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57519544","predicate":"biolink:affects","object":"NCBIGene:64840","sources":[{"id":"urn:uuid:1e8c3c35-0e1d-4a8d-946e-584c639d5245","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12020","original_object":"UniProtKB:Q9H237"}
{"id":"ed88bd31-117b-46f6-ae5b-050a9cdfe9ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4314","sources":[{"id":"urn:uuid:18493242-b4b5-4d05-ae39-7b0c9abb36be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P08254"}
{"id":"5f8ed0af-7a9e-410e-bcb3-8c8c2957ccd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6804","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:9eb52452-04ae-46e7-8c60-4e3f1eec287f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7438","original_object":"UniProtKB:P10980"}
{"id":"817879ae-376d-4f64-820c-df47e2261f45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817514","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:40014048-f643-4361-8307-fc88d215b457","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11404","original_object":"UniProtKB:P17752"}
{"id":"a9609696-1d42-4da0-859a-cb889c54208b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:810","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:251a7bd7-50f2-4ff3-adc3-eddb06ce5b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:810","original_object":"UniProtKB:P49682"}
{"id":"37ca62bf-b0de-4af5-a3cf-b215a23a4ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124090478","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:a08c59f3-25c1-4db3-b932-9acff8579860","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10458","original_object":"UniProtKB:P29597"}
{"id":"022befaa-4949-4c0d-8cf2-15146b4dec4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46225540","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:3c8159d9-69c9-4073-a4da-975e22bb7f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8181","original_object":"UniProtKB:Q13153"}
{"id":"9b428824-aaf1-48e2-b9b1-6aed85d7d0f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32010","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:1cd25b8d-5469-46ad-941f-353580e34280","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4288","original_object":"UniProtKB:P42263"}
{"id":"ec08b6ef-78b8-4d66-977b-850d3e361a94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:53db8d53-6e78-4d16-a8b0-cb21bb501fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P34995"}
{"id":"75bde947-977c-4a3a-baa7-d670d674bcc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311372","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:ad114378-2957-4335-9b9c-36b6b03fb8a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2050","original_object":"UniProtKB:P30874"}
{"id":"0a00398c-8030-4ac1-96ba-69a83e9b2b39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145867030","predicate":"biolink:affects","object":"NCBIGene:12267","sources":[{"id":"urn:uuid:c43bf82f-471d-4821-8e19-4b3fae6b24e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12220","original_object":"UniProtKB:O09047"}
{"id":"0018b65f-55dd-45fe-b593-d70d3c6c09f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155749520","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:d5ca7baf-84c7-48b0-965b-74445aac97ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12059","original_object":"UniProtKB:O75116"}
{"id":"d5b9ab70-07db-4f31-b445-19e54d3a7f67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87283","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:60f50d02-1ded-40a0-bd19-ede999bd5b04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9371","original_object":"UniProtKB:Q16539"}
{"id":"352dc3ba-94f6-4725-ad47-026be2890cdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311274","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:6f10bad6-3b76-42db-880f-b5f34815ef72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3901","original_object":"UniProtKB:P21452"}
{"id":"d92c4054-f50b-4015-ac6d-04db5815f16f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34732","predicate":"biolink:affects","object":"NCBIGene:170739","sources":[{"id":"urn:uuid:8692e883-711a-4bb0-a1b1-9e0aa467d2cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2605","original_object":"UniProtKB:O54852"}
{"id":"c915f02f-3144-4983-910b-a842f948945d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:496b7465-a7a8-482c-b0f0-ffba7be76879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:P43252"}
{"id":"fcc5cc66-26f6-464b-a41b-8d362d911d44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58466521","predicate":"biolink:affects","object":"NCBIGene:54112","sources":[{"id":"urn:uuid:483f7864-d16f-48ec-8ce6-9913c27b707d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7798","original_object":"UniProtKB:Q9GZN0"}
{"id":"db44dd6e-0283-4611-beb3-363c3f2958d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D6OMY2L0WA","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:dd31c821-5cc9-424e-86f7-613441d88904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11442","original_object":"UniProtKB:P07766"}
{"id":"4b793fb9-5bdd-4bc5-9c6d-5734c59ef789","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:4412878f-76a7-49ab-b7fb-80569bcd93ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:O88854"}
{"id":"3fff624d-48e9-4f1a-a2e2-30f3dcaea5ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:a81a802d-16ab-4ba1-819a-a4c4a4e75553","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P41594"}
{"id":"ca47ffd8-c8f9-49b4-a263-c6bb2682fb97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:544f0f78-c4f0-48e6-8ab8-a72b716d7739","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P28221"}
{"id":"334c1849-58b0-4b8a-a329-c8d0485618e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132374","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:025c2c11-42ff-4bcd-b3a3-c29d6fbdc988","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2535","original_object":"UniProtKB:Q02294"}
{"id":"51062039-a364-42b2-a26e-9a4e06172584","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:234248D0HH","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:3a8e83bc-96b4-4ce5-8f0c-b7770b19edd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9922","original_object":"UniProtKB:P04626"}
{"id":"5a3825ab-76cd-4b52-b488-87cd640f0cad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:35C6UMO5SR","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b4f97c67-e1f9-4716-a428-93747f18221e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:101","original_object":"UniProtKB:P08908"}
{"id":"97672349-bcf9-4e6a-882f-39ca3d03465b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135586","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:64a8f3d1-5740-4f37-ac63-c8872afb41f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1979","original_object":"UniProtKB:P21731"}
{"id":"de1c499d-7af1-4151-8838-0ceea130cd7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76072","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:c8a15bff-ae45-4944-a476-e9492510c0dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2450","original_object":"UniProtKB:Q96G91"}
{"id":"62077aa1-7580-46c9-a607-99c11ec009d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6097","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:f310be45-ca36-408c-a331-8cb6f25c4add","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6097","original_object":"UniProtKB:Q62805"}
{"id":"6398d0a6-a220-4d7d-ab08-6e797b93dce4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3558","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:cd9ea3ac-245e-4d84-8a72-d39edf143e75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2950","original_object":"UniProtKB:P51639"}
{"id":"a19e1cf8-03a4-47dc-b3c2-48df47c7254f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:6257a114-da00-46da-81c9-7d92a59ef11f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P28222"}
{"id":"84a4deef-2f9c-42a4-a86a-8c5092b3580c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36795","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:14b17fac-8713-4c73-84aa-d6af9b8ec3da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:202","original_object":"UniProtKB:P28335"}
{"id":"9b38aad8-c7c7-4794-a86c-b594865380a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4028","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:482d67a4-2579-4cec-8d1d-b91c8c9e6085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4028","original_object":"UniProtKB:Q8TDV5"}
{"id":"a9759803-ccb6-4ef7-9316-21d7f283caca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71458575","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:c394e525-ff9f-42cc-8f15-ab706e7a63ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8827","original_object":"UniProtKB:P42336"}
{"id":"b798979d-b95c-4c4a-80de-e1a26cb04a50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:823c7c9c-e2f7-4f53-9ab1-f361e5974af1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P15388"}
{"id":"5d448fc6-3b2f-4e51-b9f8-18873fcce815","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135463043","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:ed8146ce-7113-4aa5-8da9-4661c4d54731","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6449","original_object":"UniProtKB:P31424"}
{"id":"1bb9d206-cd1c-4945-a2b3-3b516eb3bd90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91359","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:2b141d98-007c-4d9c-8b41-247d3361555b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8059","original_object":"UniProtKB:P42338"}
{"id":"06a9eaae-8107-4d64-bc32-22362e445185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135673","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:501c3c75-2b35-41f3-9dd4-20e4ba22417d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10103","original_object":"UniProtKB:P25105"}
{"id":"c53f0aba-81fc-4da0-b4b9-c04e72f7837b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57412419","predicate":"biolink:affects","object":"NCBIGene:6513","sources":[{"id":"urn:uuid:93ac8be2-97c5-4df1-8eba-0d9c18c27f7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8885","original_object":"UniProtKB:P11166"}
{"id":"baed0f4d-bbfe-41a7-a89f-924954ad5048","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8772","predicate":"biolink:affects","object":"NCBIGene:316","sources":[{"id":"urn:uuid:288c4643-41ce-4dc0-b2d2-10916c566659","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2820","original_object":"UniProtKB:Q06278"}
{"id":"b0238a29-e6b1-451f-ab47-5e1ff5a6f7a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32168","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:1e8de220-09f8-4f66-9c53-cbee544c54e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5501","original_object":"UniProtKB:P35462"}
{"id":"17894b3d-c470-4757-9b5e-878c2b34190b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:338ab1f4-ebd5-481b-b6e3-7e8b9a0f102c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P35346"}
{"id":"d75fddd8-00ab-4371-97d3-834a65096c77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5633","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:b4dad6a5-a373-41ab-95f2-78b9582b5ba0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5633","original_object":"UniProtKB:P30874"}
{"id":"03d32da5-395a-4bc7-81b8-39c304c5bcff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2272","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:51458287-cf5d-43ab-97ff-2f40b637fcfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2272","original_object":"UniProtKB:P41587"}
{"id":"1a1a525e-4579-4a9e-b55b-6a270fc4047b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114756","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:e5730742-3c86-4863-bdc2-dbda0678089c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4078","original_object":"UniProtKB:Q05586"}
{"id":"efb91225-6634-4396-8783-e3dc84a78209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3173542","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:b3c6c536-2f1f-4f3a-9616-5c23d0169cb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13562","original_object":"UniProtKB:Q5XXA6"}
{"id":"8cf7e112-b19f-4e30-85f6-bfc990564e9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132992142","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:9a293d70-b87e-4d19-a821-ec6db958a6b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9929","original_object":"UniProtKB:P07948"}
{"id":"29c0b6f2-d8f8-44dc-a5e6-dc8b525906ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4740749","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:f4f96a26-356f-43bc-af95-5a270af21f05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10182","original_object":"UniProtKB:P10275"}
{"id":"548b0c41-e43f-4ed6-9815-d4adfd6a9cab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:8b7537e2-9b7d-482b-966b-65d4983f93b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:P07948"}
{"id":"93424970-894d-4c79-9513-9e8075ec5beb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:125111","sources":[{"id":"urn:uuid:b1ab12ab-02db-4aac-be90-9ca042eb4b50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q8N144"}
{"id":"267527ce-a4a6-4f84-837e-f7a4f212eb5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:9702c750-51cc-4321-9691-38811253acff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P28221"}
{"id":"2ce42bb3-38a2-4bf7-9c63-3f790f3bfa29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45980","predicate":"biolink:affects","object":"NCBIGene:243764","sources":[{"id":"urn:uuid:8a0115a8-b2c1-4da2-b835-6a695ad169c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6687","original_object":"UniProtKB:Q9ERZ4"}
{"id":"14bafbcd-b4e6-4296-a695-1eab205f7bc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129165016","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:6cd1a13f-3fbd-4e91-89a9-9f2b7c09aec6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12350","original_object":"UniProtKB:O60674"}
{"id":"9f1be42e-fc61-41e8-b3d5-ea203446cfe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228907","predicate":"biolink:affects","object":"NCBIGene:18171","sources":[{"id":"urn:uuid:2231b87a-4f1b-4b20-8e42-2f2ef53c20f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2769","original_object":"UniProtKB:O54915"}
{"id":"24058dbb-46f8-4e6c-be60-8aeb01fa1d3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:43J9Q56T3W","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:62b5c12e-926e-4f38-9ff4-b685ab9e68c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8969","original_object":"UniProtKB:P42338"}
{"id":"55fd5838-4cbf-4a66-af71-a674aecb4af1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:2050c717-12c7-46e5-a282-7117ffac4ada","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P51582"}
{"id":"8638e58f-0b53-48e9-bb04-70044f910c0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9334","predicate":"biolink:affects","object":"NCBIGene:113235","sources":[{"id":"urn:uuid:59e50389-40e1-44bf-b5ad-cf8c6b1055c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4840","original_object":"UniProtKB:Q96NT5"}
{"id":"8732dc77-309d-4d5e-95cf-7d10d8b5cfdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:7075","sources":[{"id":"urn:uuid:547c1974-b7c9-40b8-ade6-bc1236bb6e47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:P35590"}
{"id":"47133276-854b-4971-a82b-a182896f4ac7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3012527","predicate":"biolink:affects","object":"NCBIGene:1557","sources":[{"id":"urn:uuid:1fdce71f-06b1-43d3-84cb-c7b86efe578e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8749","original_object":"UniProtKB:P33261"}
{"id":"de951f60-43a7-487e-ba99-114cfb3eec04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:379896","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:d7769061-fc8e-468f-a468-141831ae82a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2857","original_object":"UniProtKB:P15207"}
{"id":"2653207d-d31c-42a3-8571-5b3c99d62780","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4931","predicate":"biolink:affects","object":"NCBIGene:7100","sources":[{"id":"urn:uuid:65351303-3367-4127-b2f0-00e0a490cc7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4931","original_object":"UniProtKB:O60602"}
{"id":"80b14c24-f1e3-4675-9a48-779b62e71274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44584947","predicate":"biolink:affects","object":"NCBIGene:9159","sources":[{"id":"urn:uuid:42374318-8329-4836-84b6-d8f82ed40597","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8668","original_object":"UniProtKB:Q16549"}
{"id":"f4bb109e-ae77-49e8-994b-a7de1775ca56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72200024","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:672501fd-5520-42d3-bd5d-cbba084682b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8047","original_object":"UniProtKB:O60285"}
{"id":"6f01cbf3-3944-4a7b-b5be-6068faaf18e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:0e4906ca-1761-4afc-b998-85a10df088a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P35348"}
{"id":"ca78acb4-ff4e-464c-bf49-9879e3314577","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817431","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:3ffe6db7-66ad-4452-96f4-4409ec4c018d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1818","original_object":"UniProtKB:Q03431"}
{"id":"cd7eea70-398b-4736-a48b-45d90b6a3308","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135929","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:e424432d-af33-4f67-b354-62d2971210ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:493","original_object":"UniProtKB:P35348"}
{"id":"6ff4781d-2bc3-494c-b692-44f8d6fb64f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6659","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:829f73da-b571-42a0-8f65-99c59e2bb74c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6659","original_object":"UniProtKB:P55085"}
{"id":"374553fe-9291-492c-ab39-514d84740853","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:1909a1dd-67a7-4b74-b7a8-e412fc530cbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P41595"}
{"id":"478cc9be-5de6-46da-99d0-4136271ad664","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167654","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:01286eae-3c03-4c03-804d-bd6766d20822","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3381","original_object":"UniProtKB:Q9NS75"}
{"id":"15b608ec-808c-4bc6-af59-170b587acb31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925851","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:46b72df4-29b0-4abd-b523-8972fb9bd59a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11566","original_object":"UniProtKB:Q5S007"}
{"id":"f6f39bf6-e333-4821-94aa-b20dde359398","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121499171","predicate":"biolink:affects","object":"NCBIGene:29028","sources":[{"id":"urn:uuid:a7c5fdc1-457d-4704-a4a4-226a6237b313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9521","original_object":"UniProtKB:Q6PL18"}
{"id":"d0d1a87f-19f8-4d76-8266-5c08ea987e94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94306","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:4c36b509-1a07-41a7-a6de-2d5029180e47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9664","original_object":"UniProtKB:O15379"}
{"id":"4adf8a11-43b3-4b88-a272-4f57f46072b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11540659","predicate":"biolink:affects","object":"NCBIGene:10188","sources":[{"id":"urn:uuid:596b04b4-6034-4e8c-ae20-5e011d929938","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8193","original_object":"UniProtKB:Q07912"}
{"id":"e9e5ad46-2785-4273-be0c-bed71fa2f941","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:520819","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:493ce446-0ae9-4f60-b53b-d3e189b28a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4191","original_object":"UniProtKB:Q9Y210"}
{"id":"a51b6a5b-5938-4370-87cd-0ac6b1210003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755253","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:bb56ff04-958a-41b0-aac6-fa07cc6c1dd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6989","original_object":"UniProtKB:Q9EQ31"}
{"id":"0575d53c-651b-4e50-81d4-d9a37c25ef1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138828","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:8aede799-4cbf-4b6f-8571-fb09d0a42413","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:679","original_object":"UniProtKB:P30411"}
{"id":"6aa6f2ca-9c38-4572-89eb-48350551b65f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3697","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:800f6799-7d42-48c8-a336-d7f7ac6cd11f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3697","original_object":"UniProtKB:Q9HBX8"}
{"id":"49d74d96-2955-4f4c-ab35-df811912363d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:117155","sources":[{"id":"urn:uuid:90bb3522-7c78-49f0-98dd-92267c66ec87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q96P56"}
{"id":"406c105a-bf44-4c7b-89c8-8eb41b9170e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94634","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:777e2393-6099-40ad-825b-cf070df26acb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:975","original_object":"UniProtKB:P30729"}
{"id":"58f19e82-3c2c-45fc-80a1-234c8461606b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25101223","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:e21e2287-efa8-4400-b14c-01924b2dde49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5795","original_object":"UniProtKB:Q8TDS4"}
{"id":"a50405e2-bd8c-4df1-9eb6-cd474878e5f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030520","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:e1c28899-550e-4396-aed6-6547a53c326f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10428","original_object":"UniProtKB:P42680"}
{"id":"191e76c0-aa5c-4f66-8ca3-8d7e70cc427f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33206","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:2eb2c230-4c2b-458d-b8cd-d764a4b7c961","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1773","original_object":"UniProtKB:Q9H244"}
{"id":"3664c234-754b-4af0-bd6c-405a9b5b6fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:3708fff6-e627-4572-ade4-3a44e8c28f91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P59540"}
{"id":"1ae8956c-386a-4943-a573-3e0b1a378f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90690","predicate":"biolink:affects","object":"NCBIGene:22064","sources":[{"id":"urn:uuid:40a0313d-6c7f-499d-9ff3-d81bcfdf2dd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5283","original_object":"UniProtKB:Q9R244"}
{"id":"78513809-aefb-4c1d-8041-45042f5b31c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QC4F7FKK7I","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:2bb02e86-9f1f-4989-a05c-82df4899a01a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8529","original_object":"UniProtKB:P30518"}
{"id":"a947274a-bc37-4c72-870e-72178c46e86f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422750","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:35a4d1fa-ab0b-418d-84f1-f070fa5fc5dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12979","original_object":"UniProtKB:Q99788"}
{"id":"43910e3b-5c3e-4a0c-bcc5-4ec79b43dbcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58539171","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:aae20dc4-3c98-423f-945d-364bf1c1635a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8073","original_object":"UniProtKB:P33981"}
{"id":"6db07a2a-d09d-48a6-baca-01a295622016","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433300","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:3230fd01-fe17-4ea2-b812-5332f772fc20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12729","original_object":"UniProtKB:P42866"}
{"id":"e0dd5404-1d0e-4cb9-917f-62ea43a57abd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:54257","sources":[{"id":"urn:uuid:6058c800-16b6-4c62-916b-bdcd8350729e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4317","original_object":"UniProtKB:P42260"}
{"id":"9d6c9eab-1885-4bda-861b-636f22e750af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A07663A39I","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:201d74e5-1686-4671-a013-1e860e21a074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2755","original_object":"UniProtKB:P51449"}
{"id":"a4ed4f96-de83-4190-a021-3ec0a89e0965","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102373294","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:efc71b99-cc77-448a-a659-5baeb9d42385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11862","original_object":"UniProtKB:Q9GZU1"}
{"id":"86f0a45c-0c1c-43e9-b760-d4313e2dd18e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:314","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:07c0ef40-ba8e-4596-a2f1-2f0604d182f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:314","original_object":"UniProtKB:P08912"}
{"id":"12116dbd-3dc2-4c42-8fc4-2a1006e89e90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9928892","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:5a58a6bd-1412-417a-8f43-82afaef4f174","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3097","original_object":"UniProtKB:Q02769"}
{"id":"c6ad6780-2821-470f-ad8a-21082afe10a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2QR7EI62WQ","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:43a49569-8143-463f-b996-af2338071694","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13","original_object":"UniProtKB:P08908"}
{"id":"a1075913-3135-4c79-832e-aab3f799c84a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VXT8SZ6875","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:1e6236d0-9203-439d-b6d0-51f665cd11b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13679","original_object":"UniProtKB:O14744"}
{"id":"b3ee19cf-e86d-462e-a636-70421925c300","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6922","predicate":"biolink:affects","object":"NCBIGene:7296","sources":[{"id":"urn:uuid:6ca3c342-9d0c-452c-993c-24c4fa2a260b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13701","original_object":"UniProtKB:Q16881"}
{"id":"dc225b9d-721c-491e-bdff-658002fc773e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:38b68fa7-2980-4a67-bc71-71d066534297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P50406"}
{"id":"af02eaf7-fb12-492f-b1c8-eac656f174ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91428","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:c0bc481d-1122-4485-8179-023b07bf8f2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8244","original_object":"UniProtKB:P42338"}
{"id":"49b8328a-2235-4965-9ad6-c17f50b506d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91383","predicate":"biolink:affects","object":"NCBIGene:5595","sources":[{"id":"urn:uuid:523785a2-92d8-43e4-b56f-dd2fcf97e121","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5966","original_object":"UniProtKB:P27361"}
{"id":"b4a2adc0-d1f6-40ea-aba8-91c2366dfaa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126079","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:6b67c0f0-5b71-4c90-a7ef-6bf77466897b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:451","original_object":"UniProtKB:P29275"}
{"id":"95450e02-7dab-4d9b-be3f-3bd7a5b7a7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131793","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:afb86702-5fe2-4523-88c9-fdc354a473a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:935","original_object":"UniProtKB:P21918"}
{"id":"e78c9c3f-ced6-4562-a499-79cc855232bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13465","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:871f90f5-cf36-4300-b99e-ba0c4ae477b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13465","original_object":"UniProtKB:Q08499"}
{"id":"8382586a-5115-43d1-90a6-ccac7cf30092","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:600463b2-306c-49dd-972b-f830516db3a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P31388"}
{"id":"d5921d92-62dd-4d82-8942-c21947522d37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40520","predicate":"biolink:affects","object":"NCBIGene:383","sources":[{"id":"urn:uuid:43548bfe-afcf-4773-868a-d58a8719ca9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5107","original_object":"UniProtKB:P05089"}
{"id":"a28fc9df-f801-4dfc-8205-04fc8c1001f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:5608","sources":[{"id":"urn:uuid:c4e55ed6-1a5f-4590-ac4a-c3ee7d4afc8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P52564"}
{"id":"766f1701-6a48-470d-9291-a6f78091cef9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16043227","predicate":"biolink:affects","object":"NCBIGene:5787","sources":[{"id":"urn:uuid:881cad59-4f39-40c3-a37e-70600a67042f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8786","original_object":"UniProtKB:P23467"}
{"id":"0cdf363e-aaa3-4bb8-a3b2-e7d3e168339d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93111","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:6183ad40-ad7d-4383-b8bd-e447be64636d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5275","original_object":"UniProtKB:O76074"}
{"id":"e4576b07-d2c6-4c51-b987-3518b978f82d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133023","predicate":"biolink:affects","object":"NCBIGene:3683","sources":[{"id":"urn:uuid:6d70c380-119a-4f2f-b6b3-ef4bcf8ca47d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7533","original_object":"UniProtKB:P20701"}
{"id":"4e358893-7d39-492c-a293-c4b11d2e993a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:URX2UMQ8XV","predicate":"biolink:affects","object":"NCBIGene:2185","sources":[{"id":"urn:uuid:ea86afd4-75b4-4fd6-b512-331d9c18eeb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9763","original_object":"UniProtKB:Q14289"}
{"id":"d80c9939-6a16-45c3-ab5b-19ad443360a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:9d9aa071-87f5-4c40-9e2f-6d9ddc885f55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P43088"}
{"id":"3ab9f82c-5c93-43f4-9926-65df2ab2b6c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134709","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:7176ce41-9f36-4e17-b8fe-48a03ba64553","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8924","original_object":"UniProtKB:Q9Y5N1"}
{"id":"0b97e229-1043-4018-93d5-2d76ec3a80bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64028","predicate":"biolink:affects","object":"NCBIGene:6570","sources":[{"id":"urn:uuid:b7e54d19-2c7b-48d5-9941-a255dbdaaad4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4834","original_object":"UniProtKB:P54219"}
{"id":"394728aa-ea83-4ff4-a2e5-2bcfcc15b4e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813892","predicate":"biolink:affects","object":"UniProtKB:P17659","sources":[{"id":"urn:uuid:b81017cc-c799-40cf-b861-a3774803cb27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7742","original_object":"UniProtKB:P17659"}
{"id":"1c7632e9-9b48-4622-b9c6-73081a657e0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135010","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:10cf4321-5ea4-4040-9fdd-c79b06ec86db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9063","original_object":"UniProtKB:Q14432"}
{"id":"dc0a7bc3-af9e-4004-92d4-183ea27d1c3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11647668","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:09c19847-1e55-4f74-aa8d-76ad787ff6dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1039","original_object":"UniProtKB:P25090"}
{"id":"9c2f94ea-208a-4654-91e1-941535f57c97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946740","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:66b3bf9a-767c-4618-a074-fbb8f48806e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12174","original_object":"UniProtKB:P28074"}
{"id":"73adc248-80e9-4685-8b26-d77faf598c8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NJL503AIJA","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:63d50cbe-e14c-4ddf-93d3-daaa34ca480e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11311","original_object":"UniProtKB:Q9H228"}
{"id":"29c613c5-6796-4361-9267-c6a566059bf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:bf669905-4e9a-42e5-9967-f03c21fd2419","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2298","original_object":"UniProtKB:P22460"}
{"id":"bfb449dc-1cbb-4c03-b91d-dd44c6b6fc7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3667","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:7107c82c-b214-46c5-8017-936b9c342acd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3667","original_object":"UniProtKB:P25103"}
{"id":"ea9b8c48-ca8d-42e2-8bef-dbaf29970c84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132552","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:5a7511e0-5a69-4e25-964b-000deeae3f85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:110","original_object":"UniProtKB:P28221"}
{"id":"af3e6d6a-f0ac-4383-9e91-8002427b28a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J2L7Z273SG","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:7096280f-cfaa-4782-80a8-e1d4ec1f2cb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9131","original_object":"UniProtKB:P04049"}
{"id":"9c216de2-e34c-466c-9139-8bbd3634a170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71818575","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:9a80f549-ab53-4848-a88b-37e8ce9548cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10284","original_object":"UniProtKB:Q9Y210"}
{"id":"8ad40199-1ed8-4e72-ace2-885b5228eb1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3840","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:1a73be51-207c-49b8-a819-0db239b667bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3840","original_object":"UniProtKB:P52500"}
{"id":"8003ba9c-5ceb-4d83-9dd4-8ee096786881","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817491","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:2c1111b6-1749-4452-bc30-45e4e3106378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6175","original_object":"UniProtKB:P24053"}
{"id":"5a100f21-70d5-41a0-9d6f-2f07df6f4542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48574","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:b1585b8e-69e8-48bf-94c2-08516ab3941f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7270","original_object":"UniProtKB:P23219"}
{"id":"206036b0-c6d3-44bb-be3f-4793c85cc1be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827365","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:0cc4e14f-8192-4e2d-8d23-9ff5a0ad40ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8508","original_object":"UniProtKB:P32247"}
{"id":"3b22931c-6095-48c2-bb73-1df95b6bc36d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23399992","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:a079420b-331d-4fc7-a031-775be6d4b922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4096","original_object":"UniProtKB:P24046"}
{"id":"0a82f58d-5edb-4789-8fe9-fa3080e260df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47520","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:f88904b8-cb48-44c9-bd28-88a163154c0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8871","original_object":"UniProtKB:P15538"}
{"id":"aef30ebe-e8d4-4d5b-83a1-7739f7264571","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2232","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:c7bb58d7-95ca-4301-b294-611d91c3acc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2232","original_object":"UniProtKB:Q00788"}
{"id":"a6654695-726e-4bd2-b1b1-f0c2fb4caf37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P9UTN18JVV","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:d4bfca33-9294-46db-aa7a-7086d558c69b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2670","original_object":"UniProtKB:P37231"}
{"id":"e59cd940-a5bb-4c6b-9257-9bb27a40e7d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:089c7703-c368-4187-84e9-80106e3e6eb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:Q14416"}
{"id":"cd1792b6-ef4b-4d66-83f9-b0068c709d54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:7342912","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:f8a591f5-64cb-4ac7-97f4-2f2952afd655","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5832","original_object":"UniProtKB:P21462"}
{"id":"3b291d2a-2992-4d89-a600-3f15094c961f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LDR3USH1NJ","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:7af59183-f7af-463f-a105-e54a5c5c3dc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5612","original_object":"UniProtKB:P30542"}
{"id":"8f735d9d-5e1b-4b8b-b465-7262076a8279","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5645","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:be506589-97e1-4690-8b2a-2f45b63fef67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5645","original_object":"UniProtKB:P30874"}
{"id":"2a027d21-8ab6-4f2c-8e46-845db50040ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1120","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:86374cb6-1f1a-41de-8858-133c005f0ba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1120","original_object":"UniProtKB:Q02644"}
{"id":"0ec66d98-a9fd-44a6-910b-6aaa0cc3c8a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132345","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d797825f-eed6-407c-8cf4-bf5c3cd51db9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:19","original_object":"UniProtKB:P08908"}
{"id":"8799f8cd-8642-47ba-ba97-5c92bb3446a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803245","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:58951dc0-12f6-470e-82d0-d44b11688b6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:339","original_object":"UniProtKB:P20309"}
{"id":"a978c9c6-f508-4f1a-b546-b4e1ef29df89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92807","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:a3fe21a5-4986-42b4-b4ca-cf0a9feb7331","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:237","original_object":"UniProtKB:Q13639"}
{"id":"5548c657-2d6b-4e52-bc81-645934f3066c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60427","predicate":"biolink:affects","object":"NCBIGene:81491","sources":[{"id":"urn:uuid:eada93ae-1cef-411d-ba0c-02ed5efef46f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5512","original_object":"UniProtKB:Q9BZJ6"}
{"id":"6bf1c762-20c2-4b6d-81b3-4f91a8039dec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156406585","predicate":"biolink:affects","object":"NCBIGene:1606","sources":[{"id":"urn:uuid:6604288a-091f-434b-9481-b4110d188d33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13751","original_object":"UniProtKB:P23743"}
{"id":"47ffb9bc-5b3e-44f2-aa54-4688654071a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134743","predicate":"biolink:affects","object":"UniProtKB:Q6GYR8","sources":[{"id":"urn:uuid:49554d42-735a-43e8-9b34-c0438673d56c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7367","original_object":"UniProtKB:Q6GYR8"}
{"id":"9b041dc7-b064-45db-baea-e1fd1a281b4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233306","predicate":"biolink:affects","object":"NCBIGene:23678","sources":[{"id":"urn:uuid:d0ab498a-ce68-4fca-a98b-804fa9aac99e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13067","original_object":"UniProtKB:Q96BR1"}
{"id":"a5b4e532-b4d5-43bc-ada8-5ff34ce722eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:094a5fe6-c292-4f5d-aff5-c10237fd67b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P32305"}
{"id":"fa807bd8-cb89-4339-a170-8184e55f038f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18346","predicate":"biolink:affects","object":"NCBIGene:259295","sources":[{"id":"urn:uuid:8882e73b-f4d9-4d78-bfd5-07fef4e1f532","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6412","original_object":"UniProtKB:P59543"}
{"id":"09f648bd-b2f1-4f1c-bbf3-41cb9836ba61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91810287","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:9975ab2b-94c4-4e58-8f0f-b8958d2810b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9305","original_object":"UniProtKB:O43613"}
{"id":"ceb2450c-b3df-44cf-b9ed-57a39ed5fe4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177470","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:32bfcedc-6f94-4a4e-a4df-00149ed1beb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1894","original_object":"UniProtKB:P34995"}
{"id":"a3c1c7a4-ca5a-47aa-b487-e980ec2d843f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:4f8b5bc2-4ed1-4cc6-835f-743f395ccd13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q12866"}
{"id":"b6c0c588-1461-4fdc-ada1-b8addca25c52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:65459349","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:41a54b4d-7fc3-49b4-be0b-e21a4f76cca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11864","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"ebb0c17a-c893-471d-9b1e-d1a287eb9361","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1689654","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:9d0e4ba3-6094-4ed5-b81c-43f30d392e8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7669","original_object":"UniProtKB:O43526"}
{"id":"ab0a8f6d-07c2-4f48-8a4e-a4c081b429e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228606","predicate":"biolink:affects","object":"NCBIGene:6197","sources":[{"id":"urn:uuid:84790bfc-8b45-4662-88ae-c727771124ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9358","original_object":"UniProtKB:P51812"}
{"id":"b6b9c8bc-ac53-4758-88d2-77ea5c36c75f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:116337","sources":[{"id":"urn:uuid:0473d112-af09-499e-8861-d28ab4158e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q96QZ0"}
{"id":"07e621d0-d057-4e28-95ec-f7fe715eda9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31882","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:5761e5f8-86be-4d78-9070-c7430b4b6892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4268","original_object":"UniProtKB:Q13224"}
{"id":"c0afc17d-f034-4251-9800-bf6a769126dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817412","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:fd8ec307-1680-4b9b-abf8-b0b3785b75fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1472","original_object":"UniProtKB:Q9HB89"}
{"id":"0eece35e-01bb-4d30-be91-fb5e2fe617bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8597","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:00c7d347-17d6-4139-93cd-671701b3fe21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7285","original_object":"UniProtKB:P31645"}
{"id":"4aa57e5d-49e1-4614-9445-f0a65fcb03e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7454","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:99fc0096-49b3-405c-8e41-a1dd24e455e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1663","original_object":"UniProtKB:P35372"}
{"id":"9908b2c3-134b-4785-81de-383e1b5b8b39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a9c943b9-f564-47a2-8c19-99ce3c893e56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P14416"}
{"id":"68d2c707-e005-4c08-a83e-1d7c7eb6fdef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11122","predicate":"biolink:affects","object":"NCBIGene:170482","sources":[{"id":"urn:uuid:79d4766b-89ed-48f4-8bc7-a4db02c86683","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11122","original_object":"UniProtKB:Q8WTT0"}
{"id":"b954ee57-8dd8-460e-b72b-a97648c04ce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:776","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:d698d67f-a202-4e27-a9c8-2398138e1943","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:776","original_object":"UniProtKB:P51677"}
{"id":"b864beec-fc7a-4b26-8b9f-8643913a7fe3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IA262432Y9","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:75e49cae-1b0d-4c02-8ec5-1133573a1490","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4304","original_object":"UniProtKB:P48058"}
{"id":"1d28f7f7-17d5-4593-9654-e0fb521a641f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:16def4a9-56d9-458f-bd1a-b43c28935d2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2344","original_object":"UniProtKB:Q16322"}
{"id":"e0b1d9e1-d8a4-4b85-84b3-705804c0ad62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:347732","sources":[{"id":"urn:uuid:5e2c000c-6930-42df-b637-fcf31558a752","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q86XQ3"}
{"id":"b40797d4-f18c-43db-92cb-b98d7c821bc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C35RF1MWQZ","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:acae012e-f4e3-4aed-b793-b1ecc1bf31fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7339","original_object":"UniProtKB:P49768"}
{"id":"7757ee53-4a85-4f99-a139-339c8f2731e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6185","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:8de9563f-71d8-4df1-99ee-5f2469437460","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6185","original_object":"UniProtKB:P52500"}
{"id":"687806ea-8a47-416f-93b1-d0fe6f6a16e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6702","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:08ceac42-3327-4228-8dce-08a179a3635b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4797","original_object":"UniProtKB:P23975"}
{"id":"bc05c9fa-b92c-441c-89be-0de068c0dc56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15760","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:566a10d4-f06d-4775-ad0f-02b668cf8e0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2148","original_object":"UniProtKB:Q96RJ0"}
{"id":"cfa36179-9413-49a9-897d-fc75eaed2545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11655079","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:405c0223-15b0-46e9-84df-74814508eae6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7725","original_object":"UniProtKB:P55055"}
{"id":"e104f7d0-8118-4954-a6c0-40d2c3de3169","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:3fa1637a-06ca-4397-8361-e0d4fba4d5d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P30680"}
{"id":"a71073a1-411f-4dcc-a82c-21eff5522b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:7bdccfc9-6029-432f-9287-1555bf9089dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:Q92736"}
{"id":"ef1c06ee-e313-44c2-bb57-0b2f4663b773","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:4601797e-27e3-4f64-9c66-40083e4d8123","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P23811"}
{"id":"0ced6ca8-d426-47e8-bedb-76e4e8315c8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145966622","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:203fd35e-3d7b-4971-b573-6074c9f6c922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12324","original_object":"UniProtKB:P48039"}
{"id":"e69324ed-43f0-4d39-97da-a356ca13853d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155801618","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:e2bf99d8-3303-4983-b575-b6a5df2631e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11766","original_object":"UniProtKB:P0DTC1"}
{"id":"1bd78669-e83c-4aaa-8f5b-0b4ceb46f5ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47344","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:4a42be43-9596-49a4-a4ed-ec4f9272fc0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5680","original_object":"UniProtKB:P11802"}
{"id":"e5c1ee17-fe9e-4435-bdbf-941a0522ad9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75283","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:a9a353ff-f3da-4d38-9201-2832b7c6869c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11355","original_object":"UniProtKB:P31749"}
{"id":"a6362365-9299-41f9-82a1-5564ff40a8ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52140","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:5941c8f5-132c-48fd-8317-eb4fbd75d3d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10285","original_object":"UniProtKB:Q9Y210"}
{"id":"26fd4cea-d6cf-436f-a141-1ed55cf8322d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65408","predicate":"biolink:affects","object":"NCBIGene:259296","sources":[{"id":"urn:uuid:65908a95-a1c4-474e-ad82-366835fd04f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9675","original_object":"UniProtKB:P59544"}
{"id":"48777601-8b23-4b90-946e-844655bfb2d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:20417e9d-b465-4762-9b90-cb493a4c332a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P35348"}
{"id":"7d739981-cff0-48a3-b37d-b2ea6d2cc0d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YKQ241VJ92","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:ba3daa59-da52-4611-bbae-8542f6fd1ed6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5689","original_object":"UniProtKB:P06239"}
{"id":"fcc1456f-9aed-4d3d-907b-4d36114d4b59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10780929","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:0b71a4fc-04f2-4691-940f-60b209ac9114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3114","original_object":"UniProtKB:Q02769"}
{"id":"2d929dba-e2cf-4a55-b075-ebee4bec6231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:afe622fe-9f30-41b2-bf22-ed46e7b53fbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P11229"}
{"id":"e15f19b8-021f-4768-9e96-6bed75269810","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156732294","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:d12193d6-5bdb-42b2-a4a2-2505352e0d26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12393","original_object":"UniProtKB:P01116"}
{"id":"dc00dd8d-a1e7-4442-a6c1-7571b6d4bc52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25113689","predicate":"biolink:affects","object":"NCBIGene:1559","sources":[{"id":"urn:uuid:45fa7240-cc3a-465f-9a8f-f82b835a0779","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8747","original_object":"UniProtKB:P11712"}
{"id":"5c8b99bc-241f-4ee2-a426-656dfff8d9ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:105539874","predicate":"biolink:affects","object":"NCBIGene:8564","sources":[{"id":"urn:uuid:095a4b8c-1ef4-4a39-92a5-847d855ee6fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9007","original_object":"UniProtKB:O15229"}
{"id":"a95065db-aee7-4611-8074-ad51e5befc66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37994","predicate":"biolink:affects","object":"NCBIGene:6582","sources":[{"id":"urn:uuid:62f074a4-3faf-4ada-ae1f-452e189f2ed6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8482","original_object":"UniProtKB:O15244"}
{"id":"5bf650d0-4e98-4f5f-993d-dc5163e1a2a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W530IRZ40G","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:d4ebca60-a3ad-4b6d-b89e-1004ddfe9f12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12038","original_object":"UniProtKB:Q96RI0"}
{"id":"01b3aec7-1eb6-427b-846b-5f6d026d168c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2277","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:c3a5b6d4-4e35-43ef-85cc-c0e3c61732d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2277","original_object":"UniProtKB:P41587"}
{"id":"cf871d4f-c35b-47fa-b72c-2a58576e169b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:29256","sources":[{"id":"urn:uuid:f6523a43-150e-47b8-8e42-1862ca7955d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P35370"}
{"id":"ff3ac5d9-705d-4564-9c9c-1785e806576a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6324595","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:ac1ab434-3d81-486e-8fbd-042192c715a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1074","original_object":"UniProtKB:Q9Z0U4"}
{"id":"1b6b21f5-5faa-4f38-a4d2-9eebea551817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16143287","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:d035d0c9-6025-4303-afd2-aa3b726c2e0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3760","original_object":"UniProtKB:P24530"}
{"id":"e6720266-9090-4732-b518-fe1b415b9150","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10090192","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:083c2400-3f98-4eb2-b2db-2bd1c3f75e50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2652","original_object":"UniProtKB:P13631"}
{"id":"85011213-13c1-4ab7-9b08-0b7239e8a6cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4633637","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:504a49da-7d3d-41ed-9ea4-afb6be3866d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11082","original_object":"UniProtKB:Q9H2K2"}
{"id":"9e4dc155-695b-4045-9b61-924a65cae31c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53380924","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:dfd5fb46-bcef-4343-a046-70fd2ab82f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6407","original_object":"UniProtKB:P41594"}
{"id":"5c0fda53-b55a-407b-92cc-0f4932a2a8de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:6bfdd745-3027-46dc-a6bf-44c0aec68ff5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P20309"}
{"id":"c72287ca-a70b-4aa1-8c8e-613e73958631","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9948","predicate":"biolink:affects","object":"NCBIGene:7162","sources":[{"id":"urn:uuid:18363423-b4fd-422c-a6d3-7bac06848ced","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9948","original_object":"UniProtKB:Q13641"}
{"id":"7505782a-8ce9-4e06-9028-92d537f915ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16828","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:c6c52343-af20-426e-b998-d198e6d5c72a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:717","original_object":"UniProtKB:Q6DWJ6"}
{"id":"d803fc2f-797e-48e2-acc6-79b77894d4e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1560","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:b70b7290-9ed6-49e6-b4d6-d98c674d3df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1560","original_object":"UniProtKB:Q63634"}
{"id":"3296d36b-90c2-48f5-9533-0f522922d276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156338076","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:00f449ba-e826-4cf8-85d1-5a63e479f5ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13487","original_object":"UniProtKB:P29597"}
{"id":"b9b849ff-ca70-4554-9646-befdb05793ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64213","predicate":"biolink:affects","object":"NCBIGene:5499","sources":[{"id":"urn:uuid:435897b3-e30c-440c-b1c4-8fdfeab77307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13081","original_object":"UniProtKB:P62136"}
{"id":"64fc3440-62ea-4040-a0eb-30a9a37382f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6546","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:16aa63d5-1779-4664-936f-2fbe0fcb694e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6546","original_object":"UniProtKB:P41968"}
{"id":"dcebb55e-f5fa-4f96-a452-e8d3feee3f25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1514","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:2242bb34-2aaa-4ee8-9f7f-4ee9421d71b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1514","original_object":"UniProtKB:P25929"}
{"id":"e6d6ddfc-d86c-49aa-a2aa-a6535c0ab955","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:aa11564b-04f0-4427-b948-7b46fef45021","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P06241"}
{"id":"9a868e19-2d95-44fd-a120-e0a551655349","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137064","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:f68e71b3-bce2-4305-8c78-0073c0ec7490","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7797","original_object":"UniProtKB:P37173"}
{"id":"ba732d21-cd98-4242-b03b-8e7556e06aa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4371","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:92a4f42f-c1dd-462c-93c4-8cf2fdf59ee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4371","original_object":"UniProtKB:Q9HBX9"}
{"id":"83e61bc3-b430-4ac3-a9b8-b1fb8dd541cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993643","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:22f5d35b-43b3-445e-ae97-583330e1c439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12486","original_object":"UniProtKB:P08172"}
{"id":"bafd3442-aac7-4bf4-8cd6-a429ec32527c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44306132","predicate":"biolink:affects","object":"NCBIGene:4597","sources":[{"id":"urn:uuid:e8bf7736-b994-47e3-b242-f5cea534dfd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7994","original_object":"UniProtKB:P53602"}
{"id":"ce7b9dbc-3690-4d87-97e8-ad57a892c8a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:a1f8d5e3-3f8d-4762-b49b-c5cfc1e4a760","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:P35561"}
{"id":"62662ed2-5910-4de6-9697-134cc93a3e49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7602","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:69c60621-a38e-40d3-9a33-13f3e423a1e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12446","original_object":"UniProtKB:Q9NYV8"}
{"id":"69c7e809-1413-4c09-a336-4b563e708303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:f0463f70-a5e0-4ced-a598-0d13be510a2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P28476"}
{"id":"4e89ff97-dd86-47e5-9825-4be3bea18f7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:9a99885f-319a-4260-94e5-a814d8a0d956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P61169"}
{"id":"32cad8bb-88fe-4c42-845e-282c8f1ac37f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13918","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:273b54d8-4101-4cef-b9cc-9b07d0582f24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13918","original_object":"UniProtKB:Q06418"}
{"id":"162f57a2-b6d7-4795-8722-b352c3d339c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90655897","predicate":"biolink:affects","object":"NCBIGene:440275","sources":[{"id":"urn:uuid:ed717ee5-a517-451d-a239-958792af094e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8169","original_object":"UniProtKB:Q9P2K8"}
{"id":"4bb53481-e44f-4c47-9a11-1ba4bdac2aaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:9bed80a2-7a71-4777-922f-35341e69a750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P08482"}
{"id":"78e59105-4245-4f5b-8080-a2b9dae17f82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9549300","predicate":"biolink:affects","object":"NCBIGene:1326","sources":[{"id":"urn:uuid:f8dd0049-255c-4060-a474-6efec28662e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6051","original_object":"UniProtKB:P41279"}
{"id":"88648df2-b61e-40a4-b792-67f29f1a0311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51035721","predicate":"biolink:affects","object":"NCBIGene:27035","sources":[{"id":"urn:uuid:252a5ed2-f8a8-487e-b519-8bf01536954d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9931","original_object":"UniProtKB:Q9Y5S8"}
{"id":"f6663301-9ada-4ddc-926a-68ce47766ca2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85993","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:389e59b4-7698-4339-bde5-93162b9bb617","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7380","original_object":"UniProtKB:Q00534"}
{"id":"5849b9c0-efb6-40aa-acf7-daf32853fe5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587562","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:ba97350e-2a98-48d7-961a-1b7592f9fee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11660","original_object":"UniProtKB:P35916"}
{"id":"9dbffb2f-1f90-448d-b511-e3a6f8415dd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168510442","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:df354d27-eafc-4d9d-b802-0853ffd57c57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12905","original_object":"UniProtKB:P35968"}
{"id":"a8ba13ec-b3f1-4360-990f-24519912c785","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:63D4RUV1GN","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:70b21b5c-e508-4420-9ac8-095bab859c7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10578","original_object":"UniProtKB:P48736"}
{"id":"8a387f00-b9e1-41bb-a694-ea68d2927966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889212","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:ab99c163-40c1-4898-918f-a5bd7cbe4de4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4260","original_object":"UniProtKB:O15399"}
{"id":"604b3b3b-9101-4dce-8e3a-ce241c935594","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:c63a6fd2-3ce7-4644-904a-d77f62141c72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P30542"}
{"id":"858fdb5a-d310-41bf-b84d-56effce6707c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:ccf63ae8-3abd-451e-87a8-f788ca772d70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P48050"}
{"id":"25f6b8de-f00f-4c21-9805-58d1c6d0ba18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73348335","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:b6a5f60d-7b50-4999-8307-2ae0eae29bb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2972","original_object":"UniProtKB:P04035"}
{"id":"b162dc3d-ee99-4a3c-b12b-0d4d243bef56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2702","sources":[{"id":"urn:uuid:4b9ed9a4-1b3a-480d-b18a-aed74fc50f5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P36382"}
{"id":"4c4173cb-32d8-4dfc-bc7f-fc3920e0e9fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31231","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:1e5e2bd6-bcf6-4da2-a932-4890edf429ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4261","original_object":"UniProtKB:Q7Z2W7"}
{"id":"d1ed18d4-4e9f-4f11-82a6-28d677637b6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91885640","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:53251f97-3408-4c4b-bcbf-4dffa492a7fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13191","original_object":"UniProtKB:P08588"}
{"id":"68521203-0a31-47d6-8365-2ad7d757b31b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91083","predicate":"biolink:affects","object":"NCBIGene:4352","sources":[{"id":"urn:uuid:c4a2177f-19be-4f1e-a266-27039126a927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6974","original_object":"UniProtKB:P40238"}
{"id":"afa56deb-d5d9-46f0-825e-7c4569e98402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:88571090-ce89-423d-8fc0-f54d0e4c7c8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P30936"}
{"id":"2cee9fee-c5cd-4b41-84db-efd073ab30bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92290","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:10a7ee84-8dc2-44f0-8560-8d792dc287ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5828","original_object":"UniProtKB:P21462"}
{"id":"7a63ec5c-a41c-499f-981f-8e08e4f1881a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3B974D670O","predicate":"biolink:affects","object":"NCBIGene:25537","sources":[{"id":"urn:uuid:f94365ba-1c48-4061-b836-b2d1175229ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8910","original_object":"UniProtKB:Q62868"}
{"id":"9852a33c-c760-41ba-a0d0-b59be9c9dad6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996540","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:89b74e95-edcf-46ac-b961-c21c8622cef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10702","original_object":"UniProtKB:O00329"}
{"id":"b2ff043c-c8c7-442d-9568-8fe60c7b0f3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2061","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:a24c3d44-70ae-497b-a2d1-19a550a1eadc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2061","original_object":"UniProtKB:P30875"}
{"id":"76e5079f-915c-4762-90ab-1abe72c63d32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366980","predicate":"biolink:affects","object":"NCBIGene:6788","sources":[{"id":"urn:uuid:67fe2d14-0d97-4dff-b0a3-5d039afb5583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11811","original_object":"UniProtKB:Q13188"}
{"id":"a87c8758-1028-42ab-95b6-986905b5730d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138488","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:fd3c5442-018d-49a2-b320-7cd76cb21449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5925","original_object":"UniProtKB:P06493"}
{"id":"798a01bc-3839-4546-a214-2f5d40826420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92140","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:60aa34c9-92b9-4727-a72b-a845e0c62f8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4240","original_object":"UniProtKB:Q13224"}
{"id":"55e5178c-fe4b-4352-baef-10ab52be9493","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081965","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:19684bf0-9e97-431a-8358-757ba6469803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9887","original_object":"UniProtKB:P49336"}
{"id":"4cbee6cf-05c6-43af-8a82-6f8995091f78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90027494","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:194e7ab0-35b3-424d-8ffd-5bd19685ab6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11590","original_object":"UniProtKB:Q13822"}
{"id":"bd5c4d5c-2905-40eb-97f4-245f4fa1781d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817491","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:feb6bb7a-f916-4174-9ee8-509643b824af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6175","original_object":"UniProtKB:P28336"}
{"id":"5c4385cc-bee7-4c2a-92c1-347d4bb1d881","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76328755","predicate":"biolink:affects","object":"NCBIGene:5624","sources":[{"id":"urn:uuid:534c0939-f944-4689-bac9-11d0788b276a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8612","original_object":"UniProtKB:P04070"}
{"id":"0de8a057-2b6f-4d43-8a62-e1df94565ce3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10020451","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:bbc92290-c529-475d-a376-975db4528130","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:580","original_object":"UniProtKB:P21730"}
{"id":"7c9bc15f-6877-4a20-8816-1c1271157418","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22991950","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:09ad6408-e8f0-4974-a62f-eada08566144","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:326","original_object":"UniProtKB:P20309"}
{"id":"d10c04bd-dee1-41fd-94e0-fdb4e936df62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553156","predicate":"biolink:affects","object":"NCBIGene:108","sources":[{"id":"urn:uuid:aa4c1c2a-ffbe-4960-8266-ff24e400f446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10214","original_object":"UniProtKB:Q08462"}
{"id":"7b59f711-d6c4-46dc-9ac8-454a70f87274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31882","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:dc50786e-e878-4c11-9100-3d841269e12a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4268","original_object":"UniProtKB:Q14957"}
{"id":"ffa98876-2619-4159-955f-1e3cc43375bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:35C6UMO5SR","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:1721b02d-9c3c-4300-85fa-e6c834c28035","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:101","original_object":"UniProtKB:P31388"}
{"id":"eefbd40c-e165-40cf-8931-31bb845240ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RR6P8L282I","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:93828e85-ed83-41ba-acf7-30cb6428760d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9289","original_object":"UniProtKB:O95977"}
{"id":"5aa91bd7-0fe5-4921-83f7-477d25f1fe6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16934","predicate":"biolink:affects","object":"NCBIGene:1491","sources":[{"id":"urn:uuid:7a7a470d-6244-4a62-a125-2c8a874191e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8859","original_object":"UniProtKB:P32929"}
{"id":"298bf2a3-3498-4168-9dfe-5ad4b77500a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108301","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:d21cc480-d7d9-4123-b419-273d2b737941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3076","original_object":"UniProtKB:Q02769"}
{"id":"5d156e79-fbfe-45c2-9fe0-93d2360425ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:27474d18-63bb-478a-99b4-7fbbca64f5c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30936"}
{"id":"e0c0deaf-d16c-4325-8928-6a6190e87d59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7444","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:9f814dfd-62d6-4847-9d84-819aa994b2c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:554","original_object":"UniProtKB:P08588"}
{"id":"c7a57c46-cb8a-4c44-85d1-9d0491d3a79d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:faacb209-1454-461d-9eb4-311d9cc64c08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P50406"}
{"id":"c296c5b0-e00b-4b0b-a3d3-86bcf2a24b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C1Q77A87V1","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:2e845908-5cce-42ef-bfdd-13b3109194cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6472","original_object":"UniProtKB:O75762"}
{"id":"0e1d6052-fc9a-4662-9c04-baf5e60d823a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73389638","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:ec808dca-3f04-48a4-ba59-9c17305f4dc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9761","original_object":"UniProtKB:P51451"}
{"id":"44de89c6-68ea-4c1a-889a-dd67dafd6b25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8b25ab80-578e-49e9-80d0-dcbf18715162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P08173"}
{"id":"d771c409-00a5-44ac-b6c4-d37d2a5787df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:24247","sources":[{"id":"urn:uuid:9bb85de9-c361-4cc4-9e06-16163ae40684","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P48442"}
{"id":"4f36b417-ac64-4a43-b2d4-8ad2a2df0a05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:511738f7-929f-4765-9379-f3089d964188","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P23811"}
{"id":"db964c8c-5a91-436b-8527-4616a9dffaf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:7220","sources":[{"id":"urn:uuid:d517c672-c0ba-496d-b127-3c3f693d68e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:P48995"}
{"id":"692458a6-1cdd-4501-94a4-90fbad2c3805","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52946595","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:d0435d1c-9176-4f20-8a26-a6ba4d51e3ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11515","original_object":"UniProtKB:P43235"}
{"id":"59e7ae0b-8d66-4da8-b8d3-ea484fb333ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4495","predicate":"biolink:affects","object":"NCBIGene:83535","sources":[{"id":"urn:uuid:8fba49a4-6170-4857-b820-a35cee7e1b22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2409","original_object":"UniProtKB:P70673"}
{"id":"db8f1a32-f11e-4164-a273-06b2d6dbbf25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:661","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:c3bf51fe-faa2-441e-b9e6-bd0c62fdd4af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:661","original_object":"UniProtKB:Q61125"}
{"id":"4a97020e-757b-47b5-ba36-ccdc560c76a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11675244","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:afaf87de-aa71-407d-85b4-e5344fe82f1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11400","original_object":"UniProtKB:Q13526"}
{"id":"e8edc40c-d7f8-4360-8392-5ad3f1106f81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68558","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:e7f69d8c-3b59-406c-95a6-e714417fb66d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1765","original_object":"UniProtKB:Q99808"}
{"id":"e0faef0a-74cb-4959-b817-a746fc6dd501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YTL7A418KQ","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:d5803de6-97dc-44a0-b92f-0f3ec9dbc28c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8391","original_object":"UniProtKB:O15379"}
{"id":"a5039691-8b4b-48db-9e42-95fc9d6e1661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:0c6412f3-22a9-42a6-8d0b-54f7a043a4c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4262","original_object":"UniProtKB:O15393"}
{"id":"3958cc54-b973-410c-aa0c-0a73a59e46a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16168801","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:4f869d6c-dc5b-415f-9947-c4c03c4470ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11259","original_object":"UniProtKB:P30550"}
{"id":"1f47aa92-27f9-49a7-a86b-739a2092f68c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1253361","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:781691ba-5d65-4d6f-9756-fbe30f8ebeba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7810","original_object":"UniProtKB:O60885"}
{"id":"240179c5-4005-45ad-abea-11988f732ee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146267141","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:2b92d9c0-93a2-484f-ac62-652e6c58c099","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12075","original_object":"UniProtKB:P48736"}
{"id":"f83f6055-8d73-415d-945b-12834c1cd551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194898","predicate":"biolink:affects","object":"UniProtKB:E2JF22","sources":[{"id":"urn:uuid:a583d2a0-209d-4bf6-8e77-712b4f9c8c69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10249","original_object":"UniProtKB:E2JF22"}
{"id":"396bf5e3-0e77-4a72-9148-1694aae667c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817522","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:636befde-d998-4017-bc7d-c40f293d71ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11458","original_object":"UniProtKB:Q8TDU9"}
{"id":"0025fd07-f4b1-4273-ae79-19d7bfcdc431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230501","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:b3745728-e7e9-492a-a873-98095702943e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7491","original_object":"UniProtKB:Q9UQL6"}
{"id":"eb2ae4b5-7d27-461e-b2b0-0e8ba57ffdc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R9Y8EY0G42","predicate":"biolink:affects","object":"NCBIGene:63885","sources":[{"id":"urn:uuid:6c051758-0d86-43e3-9a99-f26ff8be58a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9617","original_object":"UniProtKB:Q9QYJ6"}
{"id":"43ee4e93-5c46-41b4-a606-a283dbff127f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:574","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:5464283f-b4a6-4b7f-b43a-4f5d9317f660","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:574","original_object":"UniProtKB:Q9P296"}
{"id":"c2575c7b-507f-410b-9d1a-903442123531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15608077","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:67ed839e-7d40-4a7a-8ef1-44b4173102b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1217","original_object":"UniProtKB:Q9Y5N1"}
{"id":"abc9ef6d-c5a4-4c9d-8105-9f7221b02b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4917","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:a962cdcc-b39f-4d7a-94a7-5b5a19cfa7e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2425","original_object":"UniProtKB:Q8BLA8"}
{"id":"0d3b779e-8674-42f1-9c96-a718f00bae84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8888","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:374958e2-f3ed-4c4f-ae0d-d27a8ad88f13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7295","original_object":"UniProtKB:P14416"}
{"id":"2c664cfe-e7b7-4d22-bbca-6a4edd23e874","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125640","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:14973f95-47f7-4f42-8077-1f0915fa3170","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:372","original_object":"UniProtKB:P28647"}
{"id":"814a2482-c483-45bd-b33e-570f00704d96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194340","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:18a96c51-7981-4a1b-94f5-6ea1b837a506","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12647","original_object":"UniProtKB:O95180"}
{"id":"b6cf54fa-e19d-462d-ad0a-cfe8c9bc1b18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16036927","predicate":"biolink:affects","object":"NCBIGene:7915","sources":[{"id":"urn:uuid:2f2f7788-e6a7-4d7a-9d0f-b66659f69854","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8841","original_object":"UniProtKB:P51649"}
{"id":"a140a7be-9b37-4e3c-94fd-e87beca5dfef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118419773","predicate":"biolink:affects","object":"NCBIGene:22848","sources":[{"id":"urn:uuid:ccbf8fbc-01d8-468d-b4e2-3ab42aa1cb75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11957","original_object":"UniProtKB:Q2M2I8"}
{"id":"27a29263-85d5-4dd8-af14-0ebb8d8c5aea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95079","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:5f52a211-e556-4c07-8b24-6ddc2bef5e1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7523","original_object":"UniProtKB:O60885"}
{"id":"3c5ab7de-1b87-4d3b-8572-79db47f3af3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75393","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:77646800-9d8f-4ff4-8365-8c6ef2536c84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5290","original_object":"UniProtKB:Q02156"}
{"id":"e9218c09-018a-4127-9cf0-85116bbd89cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111176","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:960d524e-664c-45b1-b976-75b4ab893492","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:950","original_object":"UniProtKB:P14416"}
{"id":"302368b2-b572-4297-b7dd-90adbc9745ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7689","predicate":"biolink:affects","object":"NCBIGene:81033","sources":[{"id":"urn:uuid:b8bcc01d-8c77-4dd9-8f4e-b688ac57e647","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7689","original_object":"UniProtKB:Q9H252"}
{"id":"f8382491-5f6c-4712-88b2-c6860a88a574","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:419c3631-a5fb-4a50-893d-3e977cfc20ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:Q04771"}
{"id":"ba7eacea-678b-48a4-a65c-51fe6d82d86a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173496","predicate":"biolink:affects","object":"UniProtKB:P04176","sources":[{"id":"urn:uuid:bbc8c90d-1903-4008-b63b-40ffac1a5069","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5093","original_object":"UniProtKB:P04176"}
{"id":"99545ea8-51d7-4828-96a1-8ac826ae1bcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:42bcb622-992b-4313-b1db-880911292586","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q9UKV0"}
{"id":"612a7c6f-6d9c-4241-9f1b-5c208766753c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8CZO0970G3","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:fb777bd7-cfda-4a92-86d6-fe0d03a8d085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4241","original_object":"UniProtKB:P34903"}
{"id":"3bf560e5-edca-4ffe-bcca-f55407403cbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8093","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:3ee58108-ad65-4e83-b2a6-2202dda6e473","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:485","original_object":"UniProtKB:P23944"}
{"id":"e1b09578-27a2-445e-9d82-60230e84377c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17650","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:1043921f-93aa-400c-8f94-1ef4db63b934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2868","original_object":"UniProtKB:P04150"}
{"id":"f1f0fcda-c69f-4ac8-8d60-e9eb934c260a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RAX5D5AGV6","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:499aefb9-04ed-4c9c-95f6-681fe3cd94fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10615","original_object":"UniProtKB:P37288"}
{"id":"97402662-e607-4f48-a888-b3f39691180d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:b6afc939-db11-42d9-95ca-cb7b52fb9516","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:O15554"}
{"id":"6944386b-1fad-4247-8245-3e7c332e92ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5855","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:4a0f8046-71e0-4fe2-a763-1e664b6f35d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2713","original_object":"UniProtKB:P78348"}
{"id":"a75b6db9-4fbb-4089-9667-9880ee4f2d1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:372b2965-06b9-4ab1-bcfd-1974d6153cab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:O43603"}
{"id":"f6531266-0fe9-49f2-a388-01e99062428f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5001","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:d83af0ca-16da-49d0-9593-bb05266d53cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2662","original_object":"UniProtKB:P35523"}
{"id":"c7b95d37-a531-42d3-9071-7452dbc7d8e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:51673d4d-b4a9-4b74-ace1-600a19f95a5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q9P0L9"}
{"id":"287dde8f-9a81-4b59-a5d8-2de465b25b30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:56f57b56-76f4-4b65-a3bf-207967a2fc99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P47898"}
{"id":"f12c5a2e-b503-4df3-ac5b-2190ce547a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1524","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:829489f0-4d35-4ca7-abb4-47420c2838eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1524","original_object":"UniProtKB:Q15761"}
{"id":"8bd02640-2fe6-4f56-b35e-c113a1f66853","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5491702","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:66fa5ad3-23b2-415a-b7a3-89619bf9bb2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3948","original_object":"UniProtKB:P30553"}
{"id":"384817b5-3387-4626-a39e-92f163fad67e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11993875","predicate":"biolink:affects","object":"NCBIGene:1548","sources":[{"id":"urn:uuid:7593ba32-db0e-4d47-95e5-819688b0941b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8756","original_object":"UniProtKB:P11509"}
{"id":"e23535a8-d1f2-453b-8101-4f06f911d9c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9935197","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:50618972-6092-47e0-a216-b10c1bddf8ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2688","original_object":"UniProtKB:Q03181"}
{"id":"a691822f-8971-482f-b273-a53211f365c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11224758","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a25402ca-e901-4bb6-a8ed-3399d2470d4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8435","original_object":"UniProtKB:P14416"}
{"id":"57310a10-9d99-4033-875a-72c3f65db430","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9927707","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:aca9e004-3837-44e3-b565-344ccfb86121","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4248","original_object":"UniProtKB:P42261"}
{"id":"8b76652f-fec2-45ff-b770-9248ae8b2703","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9017","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:0dea1bd0-82e6-469d-a369-3b3e088b6de4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13093","original_object":"UniProtKB:P43166"}
{"id":"a8ace22e-09a7-4c0b-84b9-f4bd49ab07fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16119086","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:4995de98-8c9a-4d16-8a2b-798788fc58be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9058","original_object":"UniProtKB:P58406"}
{"id":"5190a174-48ac-4d4a-be0a-c0e5a739f9d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11372147","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:1645e5e1-5d8c-4f95-baad-fc3cfab4158a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3137","original_object":"UniProtKB:P37268"}
{"id":"0f762596-d224-418d-a0db-c700e6f1b4b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132369","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:1b542484-f4d7-433a-ae9d-5bc11159ccdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2280","original_object":"UniProtKB:P30083"}
{"id":"c50a9386-a5d2-432d-8346-813ab1acba62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FWU2KQ177W","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:86633096-99b2-4de8-9c71-bb82aefd2f7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6278","original_object":"UniProtKB:Q8BLA8"}
{"id":"aa17ccf6-0782-4599-a127-105eed6f6c75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:3af8187b-f0bc-4d7d-b3c5-977da648ec7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P43088"}
{"id":"ade982c1-781f-4d76-b5c9-2368468a99be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135379","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d7220b77-209c-4c81-9d10-404367d9215e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:84","original_object":"UniProtKB:P08908"}
{"id":"fbce9dfa-e6f9-4b9a-8675-864bf09806a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:5accf736-5b63-47e4-8321-5bc50ed3d1bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:P30557"}
{"id":"06486685-aba2-4c41-a0a7-f8fa93a69433","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:403f714d-f8ef-4cc0-a350-4866ef0a140d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9H1D0"}
{"id":"13c4c02c-36f7-4f0b-8c3f-c8e4e676574a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:1198d4cc-c0a9-4048-b2a7-d42608080398","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P09619"}
{"id":"c4dbfce7-3570-45a1-bc53-16797aadae62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16469","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:0b704902-caaf-4ca1-a57f-b2eaa84da225","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1013","original_object":"UniProtKB:Q99527"}
{"id":"3a10667b-bb84-4c2c-81c2-26cfe2a44ed3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85966","predicate":"biolink:affects","object":"NCBIGene:57657","sources":[{"id":"urn:uuid:81fd7d64-c755-4730-a3cc-dd5470409c1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2357","original_object":"UniProtKB:Q9P1Z3"}
{"id":"fd4f57cb-e7e4-4f6d-b377-a74dca758ed5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7571","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:ac83da36-cb67-4033-9d9d-bdf98b9994c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7571","original_object":"UniProtKB:Q14524"}
{"id":"7bd3c12a-7ec5-40e8-84e9-b4f64919df10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488984","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:d1900817-26db-4107-aaa2-493256834b38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8236","original_object":"UniProtKB:Q09472"}
{"id":"eff2b66d-b223-4d4f-bda5-e0c9e25bd50c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1167","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:48592a58-9802-4a65-9de5-882e2d520a9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1167","original_object":"UniProtKB:P30969"}
{"id":"00f6a95d-d698-4754-a10f-1833fbd9af1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168012916","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:9fa8ac26-65f5-4510-865d-3f4f894cbe45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5450","original_object":"UniProtKB:Q9UBY5"}
{"id":"84178686-a00b-4746-ab76-5972a67ee32c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31524","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:84690ba7-cfa6-4119-a5b2-f933ea330d84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7391","original_object":"UniProtKB:P11229"}
{"id":"a589dd6d-daca-4ddf-a4c0-4e5bc59bdd60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82720","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:43414bae-7c99-4c83-a32f-f8e27df78883","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4754","original_object":"UniProtKB:P31639"}
{"id":"673500b2-e64a-4f8e-80ec-315881ba28c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119137","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:85ff6919-2e62-404d-a182-11418e949282","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2095","original_object":"UniProtKB:P25103"}
{"id":"ef0a4c2b-86e7-4e81-b521-9848aa402548","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2618","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:d4c45553-ef09-40d1-902d-7d6086b7e89c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4128","original_object":"UniProtKB:Q14957"}
{"id":"6edb2eb7-945e-41f1-af2f-00118fc44dac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6069552","predicate":"biolink:affects","object":"NCBIGene:25290","sources":[{"id":"urn:uuid:3021bb0a-4c76-44e8-a55a-a930ac77f2d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11394","original_object":"UniProtKB:P12527"}
{"id":"32677f64-30d0-4dfd-9c0b-c5dbb20ccffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030526","predicate":"biolink:affects","object":"NCBIGene:54454","sources":[{"id":"urn:uuid:54508368-3973-4d97-a8a9-e6ab1b135ff1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10445","original_object":"UniProtKB:Q9ULI0"}
{"id":"f8082f9d-df31-4048-b9f3-53a5b8940246","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146019255","predicate":"biolink:affects","object":"NCBIGene:156","sources":[{"id":"urn:uuid:fe62c593-1176-40d5-acb2-8093601ed4c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10946","original_object":"UniProtKB:P25098"}
{"id":"dcd1768d-fff6-4e6d-8c09-cf3d2f98b25a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78540","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:61942a78-d39d-41c6-8092-06c51b3eede1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7372","original_object":"UniProtKB:Q08493"}
{"id":"7bd4306a-81eb-4650-a781-4c122e002e90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6245","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:321dda18-086c-43ca-ae8a-e48c52dfa4bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6245","original_object":"UniProtKB:P25090"}
{"id":"cbf6bcfe-03c8-4cf9-a488-9a742d5c1010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153520922","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:c73c96c3-b1a3-4a74-8285-3adccfb644e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12304","original_object":"UniProtKB:P08482"}
{"id":"126b71da-3cb4-48ab-ae21-b57098b0c5a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:7048566","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:3772f4d4-d8a9-4d53-b5a8-00a082be58b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:137","original_object":"UniProtKB:P28222"}
{"id":"acbd73cf-9bee-4268-88c4-6b8723f60bc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KF4ZI0CJ7M","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:1431c9f8-1875-4e29-b637-003e249b5ec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11875","original_object":"UniProtKB:Q04771"}
{"id":"88b49ec7-75d6-4a8a-b483-dfb808dc8aa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3638","predicate":"biolink:affects","object":"NCBIGene:259249","sources":[{"id":"urn:uuid:02f2d094-a384-4b28-9cba-e26fa5006a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5535","original_object":"UniProtKB:Q96LB2"}
{"id":"5872c8ad-e836-49f0-9970-673d3c213641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4417","predicate":"biolink:affects","object":"NCBIGene:12775","sources":[{"id":"urn:uuid:937c937d-8f7b-42ce-a442-5485a4ecc1fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4417","original_object":"UniProtKB:P47774"}
{"id":"ca0e27eb-afcf-4118-864f-08581b1f359d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92168","predicate":"biolink:affects","object":"NCBIGene:1454","sources":[{"id":"urn:uuid:3ebe58fa-d4bb-4ff3-bb3e-ef0a972ab615","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5985","original_object":"UniProtKB:P49674"}
{"id":"0f385f80-79b8-473f-baf2-c407e34ca532","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46369355","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:c4f78429-b6bb-44dd-98cd-112005b2e56c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10289","original_object":"UniProtKB:Q9UL62"}
{"id":"b631a6d4-b0e5-4799-b94a-3b6d56efdece","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:74981719-81c6-4ff4-9e4b-d12cba93f745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P20309"}
{"id":"3e72b824-4ad3-4326-9cee-3ccb9825cab0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94506","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:1b967dc7-5061-4267-8b38-97d496db1166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5932","original_object":"UniProtKB:O60674"}
{"id":"c5162207-7d0c-4e55-bcba-5f13f1d7aa62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177844","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:8bd96af5-7cc2-40e9-b49e-e5f63da33879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10446","original_object":"UniProtKB:P28222"}
{"id":"2c119fb0-5521-4961-9e40-2b5b9a358a9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:ffa66a18-9100-470d-aafe-d844afccccb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P17948"}
{"id":"10109d27-ff35-4982-9e5a-f0dc1fc8a5d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9938824","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:8061e83e-ff19-4344-a332-314ec73a4b90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4734","original_object":"UniProtKB:Q99808"}
{"id":"c9455c9d-1a61-4a49-935d-218ce4c2ebdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593559","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:3f801218-e769-4047-89db-1660bbde8968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10518","original_object":"UniProtKB:P41143"}
{"id":"2e9a2452-cf43-40c1-8dc8-4afe8e23ed30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164437","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:90990219-b728-4a20-9375-31c1b0c878db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:373","original_object":"UniProtKB:P0DMS8"}
{"id":"1fa50c90-7384-48c4-8aab-ce499242eafd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340968","predicate":"biolink:affects","object":"NCBIGene:140447","sources":[{"id":"urn:uuid:2db47596-31ed-4798-a274-2790d61042e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11160","original_object":"UniProtKB:P48768"}
{"id":"224cb7a0-8d08-4f66-aa01-bd38dd2ab034","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92621","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:f17f2c3b-6f20-4075-802d-d8e0a0406ce7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:547","original_object":"UniProtKB:P08588"}
{"id":"c4e66d19-d39f-46cc-adae-eaf5234be5bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34802","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:f6a1a374-0e35-4fd8-a46a-613f6cd2d783","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4229","original_object":"UniProtKB:P42263"}
{"id":"04da8726-545a-4414-b304-aa2eb8696378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:53e7faec-adde-4201-b48f-092d018315ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:Q99571"}
{"id":"9e80f2fc-266b-4112-ade1-a9fabb9a6811","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8925","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:598d046c-cb3f-4df9-b7e9-108795a95a4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4303","original_object":"UniProtKB:Q92736"}
{"id":"5368a40a-de96-4182-a1af-71e7937c0b1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:55bfda5e-fd9f-42fe-be7e-612896e406c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:P36888"}
{"id":"a9cb68f3-5cf3-4e24-9bd3-589c839b8abc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40751","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:55768026-dba2-4d6f-ac3e-cd38644afb3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4450","original_object":"UniProtKB:P35348"}
{"id":"aa7f49c5-e948-441f-b12f-d5027dd6bc5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91368","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:776b5ed9-ff4d-4d19-a013-4ed25c45232c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5693","original_object":"UniProtKB:Q05655"}
{"id":"e5266c09-fbf6-42dc-b236-8e72590dba1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QTE6AZR4F","predicate":"biolink:affects","object":"NCBIGene:6506","sources":[{"id":"urn:uuid:00b78507-a953-465d-ab8b-1082b811c3ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4531","original_object":"UniProtKB:P43004"}
{"id":"8b097e41-fbcf-4635-957f-6448c7d703ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:aafa29d2-4de5-4c6c-b22e-f64fc9ccbe8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:Q9H3N8"}
{"id":"69dbb3a5-51f7-44e7-846a-11835711a554","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90057968","predicate":"biolink:affects","object":"NCBIGene:9388","sources":[{"id":"urn:uuid:d25945bf-8a65-415a-8b3d-f8c98e20aa2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10664","original_object":"UniProtKB:Q9Y5X9"}
{"id":"a569670a-84cf-4e29-a447-5e7d213942d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30860","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:81a041da-a849-49c2-a9ec-c4ce8d018999","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9633","original_object":"UniProtKB:Q9BXA5"}
{"id":"64533689-9c02-40dd-97d7-a2d6c9992ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73224","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:1b3db668-34ad-4fb1-99bf-0caa58a8b8b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2420","original_object":"UniProtKB:Q8BLA8"}
{"id":"81283f04-8c95-4bc6-b0c4-2477e1bfc248","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:6af69613-4d19-4c90-99ec-9271f6d517f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P35968"}
{"id":"541cae43-5ac5-418f-a838-edb9b4c268bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9824507","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:61ea52f7-13fc-453c-8bed-1a60cd49733f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1920","original_object":"UniProtKB:P35375"}
{"id":"86fcb8e3-50a3-4330-b2df-f2fa97e45086","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27794","predicate":"biolink:affects","object":"NCBIGene:310645","sources":[{"id":"urn:uuid:129aa92f-fb46-4fd3-ba14-879895d96067","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7980","original_object":"UniProtKB:Q5RK24"}
{"id":"685c8cd3-d676-49d0-a195-d7ae22d461b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38937","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:c5cb75e8-09cc-49fa-a048-d52c1b4c0927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5927","original_object":"UniProtKB:P06493"}
{"id":"3a338160-bb92-47ad-86f0-c9e15510aad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138578805","predicate":"biolink:affects","object":"NCBIGene:23569","sources":[{"id":"urn:uuid:6c37ca8b-9ea8-4e64-b886-06e70684547b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12481","original_object":"UniProtKB:Q9UM07"}
{"id":"0d63a3ef-6ae3-4dac-aade-30ee1b8a6699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91091","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:3022b866-2309-43df-a6a6-6333d1d9dd78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8014","original_object":"UniProtKB:P49840"}
{"id":"97a37152-8aae-4588-931d-b285e56c3934","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3842","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:f5b78b71-97a6-4644-823f-8380a170acee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3842","original_object":"UniProtKB:P30083"}
{"id":"7bc77623-b2ed-441d-9959-1f8865af5256","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50169","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:2746f336-5511-4a26-9c90-3cb374918965","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4108","original_object":"UniProtKB:P34903"}
{"id":"ae063a9f-4d4b-42d3-97dd-4261fc7b114b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71025","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:72933910-8440-4b77-9c08-a423701def46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7460","original_object":"UniProtKB:P06401"}
{"id":"13e73f56-cbf1-494c-a991-f60a0758eb66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80345","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:49381073-8b62-455b-accc-28062c4b3a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:860","original_object":"UniProtKB:P32238"}
{"id":"f556679f-ce94-4023-be16-109ddd844bb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79999","predicate":"biolink:affects","object":"NCBIGene:2101","sources":[{"id":"urn:uuid:c72a5bbb-8bbd-4091-91a9-e417355ebf7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2832","original_object":"UniProtKB:P11474"}
{"id":"ce371daf-eb9b-4025-81fa-2ce69c9535f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3NU609VYNF","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:80e6cd45-fe7c-434d-8d04-08bd116a96ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8942","original_object":"UniProtKB:P07333"}
{"id":"f9684516-63f9-4eda-9981-f2b67172f143","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91357","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:01b9b983-c214-4e93-ad7b-90e89cd4eeb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8007","original_object":"UniProtKB:P49841"}
{"id":"75adac12-3af1-4ae5-b6b5-1dee88e8047d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ceacc0c9-67a7-4ce2-91b3-7ecb56ee70a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P28223"}
{"id":"e6e7380a-e395-4dc1-98ea-710229a07bb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3627","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:7261ee86-d539-4a8d-8425-c2e520ea329d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3627","original_object":"UniProtKB:P49146"}
{"id":"f6e10fef-e29f-48da-a1bb-55b2f8ef0ff9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1564","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:e141f4a7-4707-49ef-a867-496f1b1b5200","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1564","original_object":"UniProtKB:Q63634"}
{"id":"52bf3be6-06b4-426a-adb9-ddb0fd717e4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18388","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:aa47416c-aea6-4a03-9a2e-d0e98373ccdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4136","original_object":"UniProtKB:P04798"}
{"id":"ccf6f5a9-3a1d-40e4-a365-b8f2ace7e489","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:100022","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:a756c9be-09cb-4ae0-9c45-456d116aa641","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:419","original_object":"UniProtKB:P29274"}
{"id":"c4ee6c17-5acb-4663-a37d-3a45a90829ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76899983","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:38366329-c150-4d08-ac04-d6ff4586cbee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11874","original_object":"UniProtKB:Q9UM73"}
{"id":"176ea78b-d419-48c0-8035-b370b057546c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3652","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:7174f220-bc9f-4ebc-b405-e2fa2066bdfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3652","original_object":"UniProtKB:P51679"}
{"id":"362181ff-a04f-4564-aa6f-b753ca657fc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XZA0KB1BDQ","predicate":"biolink:affects","object":"NCBIGene:3818","sources":[{"id":"urn:uuid:790f8823-0b4f-4d1f-acc7-d984d9473fc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11347","original_object":"UniProtKB:P03952"}
{"id":"cb8f45fc-4c2e-4eb2-81f9-588d796b5c1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:f3046755-15f8-4b12-ae9c-4e95b718c66e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:Q13546"}
{"id":"e559a8c8-b6ee-4525-95e0-f7f385cb1c81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6015","predicate":"biolink:affects","object":"NCBIGene:29553","sources":[{"id":"urn:uuid:2207b923-20e7-4324-a265-7d2953dcc1e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2505","original_object":"UniProtKB:O54912"}
{"id":"0988e43b-7f96-4d3e-9188-89b8dcc43dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:7b726ee0-b57a-4ee1-bc37-046e2f7e88a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:P56524"}
{"id":"47a43c83-0871-4815-b166-f77e8f80369e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6788","predicate":"biolink:affects","object":"NCBIGene:2157","sources":[{"id":"urn:uuid:4db2be90-1fda-4baa-aa40-d666d90210c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6788","original_object":"UniProtKB:P00451"}
{"id":"0dbf8f6d-7a39-4d03-a0ff-ee210dfa8e8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3664","predicate":"biolink:affects","object":"NCBIGene:1524","sources":[{"id":"urn:uuid:91244ffa-56b9-431f-9209-a2239bf959e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3664","original_object":"UniProtKB:P49238"}
{"id":"08180fa7-4472-4295-8117-b12b3c5f909f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:00LOF6890B","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:3e88cf92-3bcf-4788-8cba-df0b55de3073","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6498","original_object":"UniProtKB:P00734"}
{"id":"7672a9d8-26e4-477f-89c6-40fed5d30ed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95077","predicate":"biolink:affects","object":"NCBIGene:23135","sources":[{"id":"urn:uuid:f2189044-f687-42a8-be66-e67de6c3160d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8979","original_object":"UniProtKB:O15054"}
{"id":"c077cd1f-3347-49ca-9754-b8f0d6116e37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6780","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:8824bc00-6b06-4bd6-a5e3-e29848a47378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7227","original_object":"UniProtKB:P28223"}
{"id":"ead8cf4f-dc3c-4e5d-81e9-c4005aeb0a33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5004","predicate":"biolink:affects","object":"NCBIGene:160728","sources":[{"id":"urn:uuid:60ccd08c-2335-4d2f-a7ff-fbf331f24f1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4820","original_object":"UniProtKB:Q8N695"}
{"id":"b3d666aa-a841-402d-b0b9-2fb87cde147b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311003","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:12cfbb57-8e37-45b4-b381-66c551aa0711","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1600","original_object":"UniProtKB:P33534"}
{"id":"626d51d2-c333-4e27-9cc4-71e2c8eb3ced","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:7177","sources":[{"id":"urn:uuid:454592be-82be-4b30-a594-63ffa06e4656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4262","original_object":"UniProtKB:Q15661"}
{"id":"166e105f-a0dd-4e7c-91db-b9d931022eac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PJ7TZW55W9","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:1f18c476-34c4-4886-b58f-89963a695b7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5995","original_object":"UniProtKB:Q5S007"}
{"id":"7fcabd35-ccc4-4709-a00d-066059301925","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50692","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:ee87f096-1f1a-4042-a00d-4ec9e9684eb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2805","original_object":"UniProtKB:P06401"}
{"id":"eca7fa6a-c2b2-4dd9-b447-6779e51129f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9907","predicate":"biolink:affects","object":"NCBIGene:6554","sources":[{"id":"urn:uuid:146e805e-b1f4-4b19-8592-03fcc814d9c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7104","original_object":"UniProtKB:Q14973"}
{"id":"656b9708-2778-4f81-9fe6-8d1d870e87b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311301","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:753b77fb-6f80-4407-a18f-aa31835df78f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1721","original_object":"UniProtKB:P47900"}
{"id":"d4bf295d-de62-4ad2-ab62-06c477507627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:194323","predicate":"biolink:affects","object":"NCBIGene:24953","sources":[{"id":"urn:uuid:c085c2a4-d5ae-41b7-966d-78bfc65f546f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1147","original_object":"UniProtKB:P30082"}
{"id":"af083aec-a5c4-49b4-bd5d-6ac4cf5d3f2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73927","predicate":"biolink:affects","object":"NCBIGene:24873","sources":[{"id":"urn:uuid:1d1b74d2-4fc7-4cb8-96c6-7b192afccae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2783","original_object":"UniProtKB:P13053"}
{"id":"4d36a152-8478-4579-8b42-8fe9d0b1f705","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947028","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:b783f1c5-51bf-4323-bfa6-7c6a588f3bcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3002","original_object":"UniProtKB:P51639"}
{"id":"cc2c79a1-1a6f-4bfd-b782-42e81ae53c08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194548","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:1368a39c-174f-44cf-b24d-eda7032f10a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:509","original_object":"UniProtKB:P13945"}
{"id":"2562cade-16d5-44b8-aa04-14b8150e158b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46225540","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:14763195-34c5-47cd-9f50-eabbd002167c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8181","original_object":"UniProtKB:O15530"}
{"id":"395208f3-e697-4fae-84c5-bcaec0db46b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:13611","sources":[{"id":"urn:uuid:f4af091d-0142-48d6-b055-fa89fd1f5339","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:Q9Z0L1"}
{"id":"ff711a54-ced6-44c2-b41c-f03eaa5dbdc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11395","predicate":"biolink:affects","object":"NCBIGene:89790","sources":[{"id":"urn:uuid:d9a78397-479a-4ab2-845f-fd4a9d596c92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11395","original_object":"UniProtKB:Q96LC7"}
{"id":"952e415c-a534-4039-9859-aeeaba9bbff8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34807","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:b20c1d01-eb4d-43d4-b0b1-69aa6e09cb4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2592","original_object":"UniProtKB:P51787"}
{"id":"6c4edec8-7c4f-4650-9c69-d1113893dff7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64207","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:84c44a89-d9f0-4492-af76-0a9d01813863","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:175","original_object":"UniProtKB:P28335"}
{"id":"195d68f0-dabe-4f51-9553-2d3c3d1c33a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393292","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:bc6f591d-ce1a-49ef-84f1-aaf632226532","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10400","original_object":"UniProtKB:Q08499"}
{"id":"91cc9021-466a-43a1-ab3c-58b88c57b863","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18784677","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:d8b71b13-7040-4602-bd61-79c49edce130","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:394","original_object":"UniProtKB:P25099"}
{"id":"877750a6-4d8f-45af-b900-d4f67841b55a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134264089","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:e6cbf56a-0e15-49e5-b2c5-f0d2c2c044e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10138","original_object":"UniProtKB:P25090"}
{"id":"4f3a3a45-4b1b-4b8c-b2f6-999e0ec45bcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2N9Q4C7WMT","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:a9201d26-cfb2-4ba4-bab3-0ee626b28282","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4066","original_object":"UniProtKB:Q12879"}
{"id":"5449f2ea-2cf4-4727-8fde-fd120bab5961","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:632","predicate":"biolink:affects","object":"NCBIGene:260319","sources":[{"id":"urn:uuid:9dcf617a-8846-4641-be10-4e6fc58c5c88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:632","original_object":"UniProtKB:Q8K418"}
{"id":"d16f1e1f-d15c-42e3-b9f6-c570ed62bf5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2042","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:25a5e0fc-f38a-4750-9051-bdb32ab07237","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2042","original_object":"UniProtKB:P35346"}
{"id":"f0ef589a-3193-4341-bdd3-710316ee758e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:260a6daa-6fa7-4f44-b971-108a018fa599","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:Q9BWU1"}
{"id":"344ee1ca-9128-41ed-ab8c-f33eeabaced0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154642303","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:98c92ed3-bdf6-4319-a77a-623e600bfa9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12105","original_object":"UniProtKB:Q02127"}
{"id":"02236bbb-1bb9-464b-8669-e122f72cdf63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0DXG50I4WD","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:473e2297-5233-485f-86d1-ae795ea6d508","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12721","original_object":"UniProtKB:Q9Y243"}
{"id":"a4502dfb-c7d1-4411-b7b7-726209259c2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:610","sources":[{"id":"urn:uuid:31ab9227-4334-49b8-8c08-25d8417dc6d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:Q9UL51"}
{"id":"8c153f26-89a7-49ff-8f7b-0397256bb4bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:713","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:c6463f01-dc04-44b9-b442-74cf9252dc1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:713","original_object":"UniProtKB:P41180"}
{"id":"3e87f806-c3cb-4bdb-9982-89d33a641fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132220479","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:92ea259e-2705-4a23-8cb7-bb5dd809378d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10001","original_object":"UniProtKB:P48736"}
{"id":"9c06a834-41f4-4f5a-8092-1132bf83adfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2540","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:559320a9-84ab-44b0-aa86-cbdceccb6b9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2540","original_object":"UniProtKB:Q07652"}
{"id":"d34599d7-26c8-4bcf-89d4-ef52389e1617","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4975","predicate":"biolink:affects","object":"NCBIGene:3587","sources":[{"id":"urn:uuid:7f4685a3-14d3-40b6-9d5e-f37f30380d12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4975","original_object":"UniProtKB:Q13651"}
{"id":"af1d0f17-d2e9-478d-bbf4-f9373f947b8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14840431","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:58eb220e-2fb9-4054-aad7-5e974e53d482","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1615","original_object":"UniProtKB:P32300"}
{"id":"2e1c6c0d-16ed-4194-b959-1b138fabbe46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124090478","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:2b682363-aecd-4a01-8867-5c258ca45f06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10458","original_object":"UniProtKB:P23458"}
{"id":"f6f3d2b1-a551-46c6-ae9d-97e50d1ae2fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17065","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:31c83766-e1d0-40c1-8d04-18e84afdb248","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6261","original_object":"UniProtKB:O88703"}
{"id":"6e3be00f-b7c1-480f-8df0-a10435f33a78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4575","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:eef117f7-109f-431d-bd4c-16ff93ffd9b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1616","original_object":"UniProtKB:P41145"}
{"id":"f4f74c5c-aa04-4390-9ead-8bc202a61824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47381","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:9830aa45-e988-4640-a444-f9fcdb53503f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2714","original_object":"UniProtKB:P37231"}
{"id":"49b6a424-b4ff-4f99-b33f-3c11b24d8fc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:300744cd-3f73-4305-b6c2-a1ae23a46293","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P28335"}
{"id":"4d506a17-387d-4138-b08a-d868e826b3f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162641050","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:cb56f0c4-6b58-4b38-a2b8-637d9b96ccac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11845","original_object":"UniProtKB:P07949"}
{"id":"311617e0-092e-4878-bedc-4b043d00db8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11422035","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:68f60830-501a-4d12-a815-04c8fd6cb554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5997","original_object":"UniProtKB:P53779"}
{"id":"65b35d58-3c2a-490e-8248-c34086641c7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194402","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:b172900a-a55b-4b91-93ce-98afd7f25bd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2199","original_object":"UniProtKB:P30518"}
{"id":"98febffe-f0fe-4562-bafe-ee36a34ed2ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24748735","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:7e21f499-6ed5-4609-951a-3540a4993060","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6119","original_object":"UniProtKB:P47211"}
{"id":"a2d58da3-2bb3-4547-9e50-48031c431f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146662729","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:74d318ca-b88f-4f15-a111-130193d6483c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11841","original_object":"UniProtKB:P50750"}
{"id":"86aadaef-e6cf-4790-9d1b-6b2b61050de5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92829","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:bd46ff88-c222-4015-b920-f545bf61ab3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8428","original_object":"UniProtKB:P50406"}
{"id":"3f514943-b9e0-4a42-8c06-a3f37b29dea0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9598","predicate":"biolink:affects","object":"NCBIGene:3689","sources":[{"id":"urn:uuid:8e891995-9039-47ce-923d-23abd07ca499","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9598","original_object":"UniProtKB:P05107"}
{"id":"c0a4d2d0-0f0a-4065-892c-78bcc2bf4e5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90217","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:0bae80e9-8a99-4db4-be87-b279d4b0aa35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5658","original_object":"UniProtKB:P16234"}
{"id":"049947da-4fb2-49fe-8431-160e53f4761e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:624746","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:2c211427-1da6-42c2-97f4-5b86a17605c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1565","original_object":"UniProtKB:Q63634"}
{"id":"f4d4be06-1f96-4dcb-8ca8-c90d1a183cf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:24f5e0f8-ebbb-4ff2-9c04-22f8f616ba08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:P00519"}
{"id":"fb9cb2fc-e543-41f2-b6c7-543764497cc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68060125","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:08e5e030-ef91-408c-8a1f-9ae5143dcf56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8938","original_object":"UniProtKB:Q13177"}
{"id":"fab57761-439b-49f0-bb7b-a46d6ce8f9cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:abdffc22-bde4-4e4e-81fb-ffe418fd36fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P14842"}
{"id":"d8b51d5d-90dd-4797-a4ce-4df4297bc309","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78333500","predicate":"biolink:affects","object":"NCBIGene:1454","sources":[{"id":"urn:uuid:0d1af5a3-6eca-4212-8890-9964599f7498","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12692","original_object":"UniProtKB:P49674"}
{"id":"b897c1db-a537-4eab-babf-8be576a9251a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S98NFM1378","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:0c69a6df-08d0-4581-bcee-fb0840927ebd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7698","original_object":"UniProtKB:Q86V86"}
{"id":"84afb32b-ca5f-4223-abdf-b0682edd4dd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140421","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:8b4ef232-63e9-42d0-bc60-2ff06c8a2e6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9602","original_object":"UniProtKB:P00742"}
{"id":"7982955b-0f85-4228-9917-cc13efe85db3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9G6U5L461Q","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:16fbd428-ccb1-46bc-a793-2c14abddbe09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7641","original_object":"UniProtKB:P00533"}
{"id":"176f3804-780e-46b0-a558-4423c6297a2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:191b6d11-2488-440c-9f96-88a61c14382a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q9BY41"}
{"id":"b6d4a214-d2b8-466f-82c8-4e037fc42d16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10353","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:4f56ba90-0893-41f9-a507-48c0d82f68b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10353","original_object":"UniProtKB:P07766"}
{"id":"2d6b4828-3fdb-4b38-b7de-4013b30cdc43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10470232","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:a917ea34-2cdc-4a84-9df0-44f8ee9e9ae9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6336","original_object":"UniProtKB:P23385"}
{"id":"1efbb614-9bf2-4bcc-befd-f9bed7a2ab72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2068","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:ee388536-a977-49f8-b0ae-040f23d138f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2068","original_object":"UniProtKB:P32745"}
{"id":"bc4afbf4-649f-4efd-b6af-2eefd2b7908e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66666","predicate":"biolink:affects","object":"NCBIGene:5320","sources":[{"id":"urn:uuid:248a8942-b37b-4379-be42-b362be123962","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13677","original_object":"UniProtKB:P14555"}
{"id":"295d8488-c1ba-41d8-be32-6fe52cef2619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:015f75d3-4ca3-422d-9073-0609f61abdb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P28566"}
{"id":"d6d9a246-c59c-45a5-ac90-55ae652a2648","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134774","predicate":"biolink:affects","object":"NCBIGene:6564","sources":[{"id":"urn:uuid:c74a391f-5c82-44df-976a-30bf2b9e17f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4702","original_object":"UniProtKB:P46059"}
{"id":"03b09d03-0c23-46c1-ad9a-542bed4161fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135679","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:50e63a8c-e6d7-4243-8854-e712f951da1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1586","original_object":"UniProtKB:P70310"}
{"id":"ffff36e7-a09f-4c02-885d-cb3d6615f768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"UniProtKB:P52189","sources":[{"id":"urn:uuid:af96de99-6034-4aa3-8fcd-cdfbb20fe9ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P52189"}
{"id":"88454b6e-8017-4b49-bdc4-33619b82524a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:49117fe7-cde7-49a4-bb23-843e2613dced","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:P35968"}
{"id":"9b8ab020-6ca6-4cdd-8796-09a44c8fc911","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:763","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:db036aad-f923-435a-ad42-770f63c4f9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:763","original_object":"UniProtKB:P32246"}
{"id":"b6c83ae7-e084-476a-937d-58a0ad4561c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:b87dfa7a-d9be-4039-b89d-b07e9428a01c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:O88703"}
{"id":"25803f49-dbc9-4fc3-9194-dc7b52b68efa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:63895","sources":[{"id":"urn:uuid:4622bee4-6b0e-4684-b4f8-52d860fc77a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9H5I5"}
{"id":"6cf443f1-5574-44e4-8dee-21d9b4ad9cf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71376521","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:30f203a4-1525-407c-a000-301b74291194","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4337","original_object":"UniProtKB:P13569"}
{"id":"4fa99811-12b6-422e-b6ed-7d8978cbc634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4495","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:629eaf81-8383-4bdb-8569-8223692c5742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2409","original_object":"UniProtKB:P97794"}
{"id":"b5ee9a4e-7cfb-4773-adb1-6f81c6b6fcc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9M363811V","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:17f10826-3629-4951-8bd3-03395e097ede","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8104","original_object":"UniProtKB:P22607"}
{"id":"c88dd833-d644-487d-9db9-1e3b00707ecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10067","predicate":"biolink:affects","object":"NCBIGene:943","sources":[{"id":"urn:uuid:a2332935-9442-48ac-a4bd-a26ebb75bb56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10067","original_object":"UniProtKB:P28908"}
{"id":"1694e614-9b73-43a7-b26c-0deda99d79f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7949","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:a0ceb761-3f93-471c-8a67-cf48aba16e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7949","original_object":"UniProtKB:P52333"}
{"id":"fa4f9bfb-4a94-4344-adfc-ca782e316817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35420","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:a83ed4e1-992c-470d-b56e-758f0b3b2fa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4290","original_object":"UniProtKB:Q9HCF6"}
{"id":"7a4c31b0-e46d-49f5-b3df-da8b507c69a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46937","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:e9905d5e-4d34-42fa-bb90-d1e034b505c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2405","original_object":"UniProtKB:P48542"}
{"id":"9472aad6-a0e6-4849-a3fd-3153194d67e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18332","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:b6977674-4e1c-4aa3-b672-3c544502cf62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2635","original_object":"UniProtKB:P10827"}
{"id":"50523be9-6174-478b-84e2-52a60d2e7daf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P909HKP24","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:7cb90009-d7cd-4d35-b70d-263e63c16aaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1216","original_object":"UniProtKB:P35367"}
{"id":"e5631c31-cee6-44aa-a582-eb8a5215a18b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ZX95B1ZWK","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:adc9ab07-970f-4a68-a9f8-b21c304be287","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1351","original_object":"UniProtKB:P49286"}
{"id":"022b1a34-9267-4427-921b-0bc24dd35df7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34802","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:189de804-e725-4a80-9bbb-040996b80648","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4229","original_object":"UniProtKB:P42261"}
{"id":"797bf3c2-6fdf-4df3-81a9-7dbdfdb98e30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92984","predicate":"biolink:affects","object":"NCBIGene:221955","sources":[{"id":"urn:uuid:a73b1e88-3ae2-44fd-83e2-3572d62c7f1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5255","original_object":"UniProtKB:Q8NCG7"}
{"id":"6915e9d6-7c9d-4487-9651-b73b7c4a80b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3W2X0WGW6C","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:537d2b0b-f2a5-4ff3-a4c0-75cdb3aacaa3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5655","original_object":"UniProtKB:P31749"}
{"id":"b24dea7f-2d33-4e3d-9d26-65eab61424d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134480550","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:7b54ef20-77a0-4cb0-8377-64b4f4ac0c41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12377","original_object":"UniProtKB:O60674"}
{"id":"1ab873a3-caee-45b8-a941-53d778dc4c56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:378d3546-c0c1-4aa5-846c-1c46a06f1b74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q9Z258"}
{"id":"c70bb0cb-aa50-49b6-8f58-086d10829209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W34UO2M4T6","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:4f64192e-b9fb-45a0-b255-944d20cf1996","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5661","original_object":"UniProtKB:P35968"}
{"id":"b99c22de-bbc9-41cc-a388-f38c3072db4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9939572","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:52fcbc95-f7bd-46cf-b50d-bf0f76de9b75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:908","original_object":"UniProtKB:P30553"}
{"id":"998dc287-8ceb-4152-8ca3-51f426016be7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2259","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:a4cebd51-52a5-458e-acb6-54af4ebe330c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2259","original_object":"UniProtKB:P41586"}
{"id":"0d734071-55a0-41c4-b3bd-ae9b325132ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233659","predicate":"biolink:affects","object":"NCBIGene:5091","sources":[{"id":"urn:uuid:349a042e-516b-4cae-8eb5-7fc7fe1a625f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13781","original_object":"UniProtKB:P11498"}
{"id":"9574e1cb-9cee-4d43-aee1-e5950d2e8149","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25175634","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:43791807-d745-4cf2-b498-309bd56026f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5457","original_object":"UniProtKB:Q923Y9"}
{"id":"685154af-9758-457b-b111-41b514e9df43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9842556","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:fe89e257-e1cf-4ab2-a18d-d416873d1160","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6557","original_object":"UniProtKB:Q08493"}
{"id":"38435df4-4c54-495f-8673-435b899f61bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44232532","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:b13e589d-8a89-4a8f-b624-01b103e90d46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10274","original_object":"UniProtKB:O75762"}
{"id":"0881ffa9-62ce-4af6-b38a-d0c67722e12e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10113568","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:7e26a3e5-affd-4283-aa0c-36d3d1dc4bc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10133","original_object":"UniProtKB:Q13546"}
{"id":"c734f56c-05bf-47d6-8f15-d5f86e46417c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3653","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:36322006-8103-47bc-987b-3ce4e0ded70e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3653","original_object":"UniProtKB:P51679"}
{"id":"832f16f5-0bf0-4a35-afdb-c225f95ae01a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127052870","predicate":"biolink:affects","object":"NCBIGene:64167","sources":[{"id":"urn:uuid:f5c12d71-66a0-499e-ac13-81add90399c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9683","original_object":"UniProtKB:Q6P179"}
{"id":"65a724b1-eb40-4584-8a0b-cdbce48119b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44351001","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:15bdfa9f-4e1a-4b21-b402-606fe37cc50f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1507","original_object":"UniProtKB:P50391"}
{"id":"9e01bf4b-5cef-4d12-80a8-30a2dde3348b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76591","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:a33d0554-4492-4261-ab54-42771d2025dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2752","original_object":"UniProtKB:P32249"}
{"id":"ea65d06d-2046-48d3-bd29-b56f5cc1dbbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2155","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:da4bfd3e-9ee3-40e1-a7a2-a88cb9f60479","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2155","original_object":"UniProtKB:P49684"}
{"id":"9861515e-98c2-48d9-91de-6febef54bf2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16739288","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:97929b8a-7585-49ad-adee-e5c2d151860f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6358","original_object":"UniProtKB:P23385"}
{"id":"c6edb959-7679-439b-a5cc-fc31f6567c32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813908","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:b810f090-9988-4da3-807e-0f212e0f4d31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10072","original_object":"UniProtKB:P53350"}
{"id":"2ed00aec-95a5-482c-8fd4-53e81abbb8bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:f8337286-4a8f-44bd-82fc-2d9e081f325d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:P30530"}
{"id":"c6847ce2-1610-4d88-ae51-d3219534df76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CXA4I8AH6A","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:377c694f-fe4d-4f1d-bf58-d11754d1ae44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11304","original_object":"UniProtKB:O60674"}
{"id":"4d4762fe-11c9-45d1-97b7-376a1f8e4910","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27791","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:ad5d3c31-c23b-4887-8372-73f378e19913","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1736","original_object":"UniProtKB:P51582"}
{"id":"7766b3eb-5ff0-4c8f-aa9a-fba3a4cd9e03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:378807","sources":[{"id":"urn:uuid:7a590a7b-ce11-424e-ac00-59894e2280f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q7RTX7"}
{"id":"22d80101-58c4-4286-85c2-58d00f3a0b1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28172","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:ad446430-4b1f-420b-91d8-d0e6a5eca768","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13140","original_object":"UniProtKB:P21397"}
{"id":"1505b6b9-9816-47ba-892b-150340d1698f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7K5O7P6QIU","predicate":"biolink:affects","object":"NCBIGene:930","sources":[{"id":"urn:uuid:e6bc558f-0e87-45f7-9175-d560abe676a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11521","original_object":"UniProtKB:P15391"}
{"id":"dd05abaa-9eb2-414b-860f-b5f11008f501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:389898","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:a15db1cd-23f1-455b-84e4-a8c91a271afd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6007","original_object":"UniProtKB:Q02750"}
{"id":"d16db080-7e4a-4d0d-9768-51f22159fb2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176844","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:563d9013-d278-49a6-b60f-7de346f2c938","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8275","original_object":"UniProtKB:P09874"}
{"id":"f83bc621-6e30-426b-a784-3eae790c33cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2315","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:1521e5f6-ec7e-4cfa-9af0-a589ece7e59c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2315","original_object":"UniProtKB:Q9UGI6"}
{"id":"6e650dfe-1a9d-425c-a83e-dc07f4a061a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53232451","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:bc77be7f-de0c-492a-9a05-f03662788fca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8123","original_object":"UniProtKB:P22607"}
{"id":"b601a010-dd0d-4f5b-84fe-7aef29f01b27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11501277","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:5855af9c-6be0-4356-93eb-a166b843d01b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2145","original_object":"UniProtKB:Q923Y8"}
{"id":"3f2daa8a-01d6-4b69-bca4-99f65ec153b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2530","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:dc01d23e-6e43-4a56-84d9-7a2c60c03d17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2530","original_object":"UniProtKB:P54282"}
{"id":"8967dbfd-11c2-469d-bd67-71537180c181","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24809764","predicate":"biolink:affects","object":"NCBIGene:57551","sources":[{"id":"urn:uuid:324d4f6b-8849-4d63-88a9-51f46c61e27d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8191","original_object":"UniProtKB:Q7L7X3"}
{"id":"8b76c144-1a78-49fd-9d66-00eb0061faa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:be96227d-13fa-4ff1-b037-c9f0cb6eb8b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P28476"}
{"id":"e88d6ed8-33a3-4d02-8496-4d8f45a1f500","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91801114","predicate":"biolink:affects","object":"NCBIGene:3416","sources":[{"id":"urn:uuid:29f44869-fc91-43e9-b20f-c9968bf11b72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8599","original_object":"UniProtKB:P14735"}
{"id":"1aad8879-eae6-41e7-b86a-5b5d2656e542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50899324","predicate":"biolink:affects","object":"NCBIGene:54583","sources":[{"id":"urn:uuid:c4b71440-3848-424e-ac8c-dda31cbf840c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11828","original_object":"UniProtKB:Q9GZT9"}
{"id":"1c489549-d2a4-4d92-80cc-5b920b232593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5IB2J79MCX","predicate":"biolink:affects","object":"NCBIGene:8808","sources":[{"id":"urn:uuid:b06a8d30-84b8-48d5-8f6b-c1b7deb44a26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12169","original_object":"UniProtKB:Q9HB29"}
{"id":"93b92157-7d1e-4ec9-8e1c-bd555fb55a34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75988","predicate":"biolink:affects","object":"NCBIGene:21973","sources":[{"id":"urn:uuid:d1decf5e-8721-47db-add4-2d3cc7d6e85a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6843","original_object":"UniProtKB:Q01320"}
{"id":"efa9eb61-d3df-4568-bb2e-cc33c53f259b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122530045","predicate":"biolink:affects","object":"NCBIGene:29254","sources":[{"id":"urn:uuid:0f438adb-26f5-4bed-9648-003f0a4a39bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11816","original_object":"UniProtKB:Q8R431"}
{"id":"ddb690eb-fca9-40bb-b9b9-03b9a085f742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5301","predicate":"biolink:affects","object":"NCBIGene:838","sources":[{"id":"urn:uuid:d5c4bbb5-10fa-4088-91d8-a4d61c84e0fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5301","original_object":"UniProtKB:P51878"}
{"id":"756109f6-326b-46f9-a9ee-a322adc826e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91107","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:3cf783af-f4e5-4c08-8656-1b1376a1b048","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8019","original_object":"UniProtKB:P49840"}
{"id":"8e9984ca-4ae8-42b3-855a-566dd41a27c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4801QYW816","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:921aee21-273e-4ab2-875a-ffa57680c380","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10000","original_object":"UniProtKB:O60674"}
{"id":"7821f383-b27d-4dd6-bfdb-df5af5bcf58b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ZO554A4Q8","predicate":"biolink:affects","object":"NCBIGene:1558","sources":[{"id":"urn:uuid:82c39860-c00f-4e27-a384-5c219bf2d2da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10559","original_object":"UniProtKB:P10632"}
{"id":"29acaa86-e911-4f0a-91e6-60e1d668873f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1778","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:7f391072-0371-46e1-ad0a-5c2b1d64b8bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1778","original_object":"UniProtKB:Q9BPV8"}
{"id":"b8c54d7a-a7b9-4c47-b6f4-e8ad02ce7968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1990","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:139a67e6-e210-43dc-838b-ae8cca389b78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1990","original_object":"UniProtKB:Q9NSD7"}
{"id":"ded931c5-c687-42f4-be07-ede162b573ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45783","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:ddbe7f77-d572-43c2-9be1-969604981275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5687","original_object":"UniProtKB:Q08345"}
{"id":"e98d566c-aa64-4187-9bc4-6feab84fc233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52946595","predicate":"biolink:affects","object":"NCBIGene:1508","sources":[{"id":"urn:uuid:920fd2cd-3dba-4866-8f21-81037b263292","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11515","original_object":"UniProtKB:P07858"}
{"id":"0786c4a7-02bd-41eb-bd49-ad0c0315c61f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7009","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:8003dd17-6054-4621-9da9-52dfc06ccae5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12574","original_object":"UniProtKB:P18825"}
{"id":"923ccbc7-8b80-484b-ac10-d8d272559383","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5540","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:21566c60-c3de-4b78-bb7a-26f465749b9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5540","original_object":"UniProtKB:Q9HBX8"}
{"id":"30c276cf-178c-49ae-9761-40af292c9bb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7851","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:bed79fd6-f4e0-4171-b25b-1db04f8111de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:302","original_object":"UniProtKB:P20309"}
{"id":"7931e523-79eb-4c08-980b-91feb3dd9393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:39OM5Y4K2F","predicate":"biolink:affects","object":"NCBIGene:6566","sources":[{"id":"urn:uuid:d1e08592-ec52-4a28-afd7-adc4b1c021c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10605","original_object":"UniProtKB:P53985"}
{"id":"255a005f-454a-4007-96c1-99b9f5349b46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4993304","predicate":"biolink:affects","object":"NCBIGene:64840","sources":[{"id":"urn:uuid:a001fff6-d5a3-4eff-b079-e5fc083dc833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12019","original_object":"UniProtKB:Q9H237"}
{"id":"7bf37ea4-82b9-409c-bf77-35e9e45e6031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28834","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:f852ec3e-f348-4deb-b8bc-0d2085a4b741","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:610","original_object":"UniProtKB:Q8TDU6"}
{"id":"8d0207e6-f2ec-40a6-8e20-55ac0f4fe18a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:6b9dcc9a-3bff-40cb-91e0-53d2941a0275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:P42338"}
{"id":"59b4d04e-b460-4fab-a804-70ad6f55df67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431484","predicate":"biolink:affects","object":"NCBIGene:65030","sources":[{"id":"urn:uuid:d4d6a894-5341-43e5-9d96-013af745f1f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10124","original_object":"UniProtKB:P80299"}
{"id":"ec47c6d5-87d0-47ba-8570-eeb689c4a8be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90851","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:abc3f7f1-d9d5-4189-80e6-26359af6ab4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7626","original_object":"UniProtKB:P36507"}
{"id":"9e6fc697-1513-4457-ac46-59d938e6e9ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50922685","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:323ce1da-1e85-4683-8d47-8f1bfccb7d5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9294","original_object":"UniProtKB:P41146"}
{"id":"4dddf8a9-1e23-4585-833c-cf159cf8b431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9156","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:3dde6528-2fa2-4b9c-a267-f5a10d3d05ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9156","original_object":"UniProtKB:P35372"}
{"id":"0a72477c-e799-4fc8-a3bd-9ff14b76bfaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:fd282a49-95dd-4c26-87a6-7f4075ca5195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P31388"}
{"id":"5f386718-4c5e-4997-b2d0-eb874577d967","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311377","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:e6c98672-3598-4b8a-9cad-a69c403d0376","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2030","original_object":"UniProtKB:P30872"}
{"id":"5bb20910-29a5-4368-b459-a27b45a709cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X8EOD1X17Q","predicate":"biolink:affects","object":"NCBIGene:1360","sources":[{"id":"urn:uuid:0007afa9-5475-4b2c-9eec-076770b35f35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8675","original_object":"UniProtKB:P15086"}
{"id":"54488342-5bbb-407f-9377-0a3269af8b94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3008304","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:73fe8200-50c3-4c8e-9108-3556b7b31fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7632","original_object":"UniProtKB:P08912"}
{"id":"77c0c591-9530-4bfa-802c-15372232a141","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71461150","predicate":"biolink:affects","object":"NCBIGene:1455","sources":[{"id":"urn:uuid:eaf55a6d-15ca-478a-acd8-a75c61405f30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8154","original_object":"UniProtKB:P78368"}
{"id":"86102f46-30de-4caa-bcbe-dab7b6387699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:2950842b-fe88-4350-86a6-8a257ed2a187","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P21817"}
{"id":"1a7df441-c0c3-4f87-bf15-67e389f17e12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:43J9Q56T3W","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:4d403014-72f7-47de-bc73-7290fe8ab6b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8969","original_object":"UniProtKB:O00329"}
{"id":"3f285ea5-e2f3-4f93-8fb0-ee87b69a03d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5697","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:42a25b0e-0df2-40a7-ade5-0e87a5de21ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:404","original_object":"UniProtKB:P0DMS8"}
{"id":"985764da-06c8-4ae0-af39-0c9b4c84d2f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67119","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:79487957-d7b6-4941-af74-955600a1b41c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1782","original_object":"UniProtKB:Q15391"}
{"id":"8ccc996e-b11e-493c-aaed-2698d54becc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1989","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:ba4c9385-2a83-4c6c-b576-7f350f70bb7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1989","original_object":"UniProtKB:Q8WXD0"}
{"id":"b83b92a6-cf3e-4ad6-8dfd-7f7a00ba49de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:b8732501-effa-4f06-88d0-645bcb31c3d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P14842"}
{"id":"e0968850-63e4-44c2-8d17-96071df86c45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53384864","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:44c79e03-5fb3-4d21-8198-73a27d746030","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6411","original_object":"UniProtKB:P31424"}
{"id":"a2cde889-0e21-4fa1-8acf-b7ae32bd2e78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:53949","sources":[{"id":"urn:uuid:8601505b-e599-4cca-acbb-8986abc2e02c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08911"}
{"id":"093304b2-f72a-4695-ad72-78e7f094c793","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HPI19004QS","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:82572a86-76f1-44db-a247-1852999727e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9649","original_object":"UniProtKB:P04150"}
{"id":"1164c99f-89f6-4d1f-8558-b3c5125306be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16122553","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:60142d01-1419-4bb0-91a5-cd213016a060","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7976","original_object":"UniProtKB:O95749"}
{"id":"0b8a7001-d519-460f-b9dc-c9c1738533f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817479","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:03ea9489-626a-467f-8306-69db346f90e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6083","original_object":"UniProtKB:O60755"}
{"id":"901923e2-c9d0-4413-9b1a-3b6451dc96d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:43EXU2S56H","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:83ae3634-ff4c-4575-bd2c-52c7b606bf0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13154","original_object":"UniProtKB:P25100"}
{"id":"055772fd-d462-4ffe-94f5-8162eca8e9ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90841","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:ca225b6a-ac50-4202-9c98-9e0b4803bad1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1776","original_object":"UniProtKB:Q9BPV8"}
{"id":"440b8d5a-4ec3-44d5-a9cd-4ec22a52cd11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:3de4e2b0-bbb3-467d-a808-079cad7cb3ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P07947"}
{"id":"4aaf6f67-00c0-449f-af3a-f38ad1b6557a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452041","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:58d8f60c-dc27-4eed-bc70-c5a594a91b73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9189","original_object":"UniProtKB:P35462"}
{"id":"68dc9a0c-cb79-4e22-a68e-f5ab77713528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118856782","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:ef38cbfc-0f1b-4d42-ad12-92036c9a491f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1171","original_object":"UniProtKB:P30968"}
{"id":"8c671bc1-1b16-46fb-9c57-08cb68b9df8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:85713MT0EH","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:6d696527-2a27-47f0-ac6d-7598c17105aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1221","original_object":"UniProtKB:P25021"}
{"id":"d52fa176-5dbe-4851-afcf-7e5f2dff5a21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:cf47e6b5-86cd-447a-be79-d728ccd1c7d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4231","original_object":"UniProtKB:P39086"}
{"id":"f14b33ed-23e3-40ac-a435-a03f0d75b700","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T678746713","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:0a1c242c-618c-47ae-a84b-fecf108f8da5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9174","original_object":"UniProtKB:P35968"}
{"id":"b262f49d-ffb5-4410-b5c0-84c0b80e1749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:a07d2f65-8ef3-4467-99dd-a2c085f69e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:O15379"}
{"id":"66c9653a-197d-4f18-9b69-d018720ab051","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7949","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:f7028dfd-aa45-4a2b-861e-aa5dc1ed7fc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7949","original_object":"UniProtKB:Q96GD4"}
{"id":"c3b06179-2565-4d72-a24d-e8a01d2116bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6102","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:7587a2c1-0758-41a2-b539-db365f46ad71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6102","original_object":"UniProtKB:O43603"}
{"id":"26674318-8971-4e90-8894-1345d10f0b65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679545","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:be205a70-61ce-4a9a-a24e-1bc22acb7bc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11907","original_object":"UniProtKB:Q9NSD7"}
{"id":"176924df-da2d-4443-836f-5e9e19ee4063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11173546","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:d27f4523-04a4-4e86-96f3-f003ce026bd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3995","original_object":"UniProtKB:P36544"}
{"id":"d61aafc9-4d82-46d3-b7f2-ccf1dc8243f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:66531bc2-4bf7-4005-956b-34a3e83e0101","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P08908"}
{"id":"57033433-6514-4af8-90a6-44b57625b3c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817482","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:8307dc29-bf55-49b4-a568-ceb8bd9c4eed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6093","original_object":"UniProtKB:P56479"}
{"id":"bc001f23-da73-4e97-b707-a1efd0598bb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:aaa12faa-9394-4eba-839e-3f4f04b259af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:P70579"}
{"id":"87bd94e3-d000-4a53-b366-6deb4d50a625","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121918","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:2eb83f0c-1f21-4e0d-828e-f7d45d0239de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4239","original_object":"UniProtKB:O15399"}
{"id":"8556354d-5ecb-46a4-b2ca-17574c4d3b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5001","predicate":"biolink:affects","object":"NCBIGene:24360","sources":[{"id":"urn:uuid:6a487995-b4b8-4955-b241-67e3f3bbfd5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7186","original_object":"UniProtKB:P02692"}
{"id":"7ae5ef7f-25e5-4f68-b196-19e468205184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32076","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:7b786d5d-99b9-4f10-bdba-ea05c06fd3cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2597","original_object":"UniProtKB:P56696"}
{"id":"7849ef69-f55f-42be-93ed-6407ef6855bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44377139","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:9088a148-db7a-42d3-8198-e3e9e59359ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8627","original_object":"UniProtKB:P08473"}
{"id":"c22dff7e-2296-4182-8d39-9849cd5458e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:09bb425a-5ebc-4c54-aa09-8b6ab83b9936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q9BY41"}
{"id":"5c399c5d-3bb4-466d-a3b4-bd84ff10f24e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841284","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:40f1fd56-09a3-4159-a44d-e6a0cc6cf798","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:423","original_object":"UniProtKB:P28647"}
{"id":"4d2717b8-aace-4512-9fa2-ca05337bf114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10567","predicate":"biolink:affects","object":"NCBIGene:259249","sources":[{"id":"urn:uuid:ec8dfac1-a38a-459d-9c5f-1e7b5e000e4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10567","original_object":"UniProtKB:Q96LB2"}
{"id":"e72b45d6-e782-4f80-a56e-d94655fa926f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:34ccf595-88ab-49ac-81a1-22613b17c737","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P28335"}
{"id":"e40b9745-949b-4a8c-ab89-d5083df7554c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17027464","predicate":"biolink:affects","object":"NCBIGene:27035","sources":[{"id":"urn:uuid:91adc2c6-6021-4417-ab10-40069ef02ae5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9935","original_object":"UniProtKB:Q9Y5S8"}
{"id":"d52d619e-b882-476d-b077-d09fa2d4bc01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2059","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:05e03c02-9a77-4738-baa7-d68022d411b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2059","original_object":"UniProtKB:P35346"}
{"id":"dbec67bd-67cc-433f-acd3-2e27ffcf5695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13785","predicate":"biolink:affects","object":"NCBIGene:3566","sources":[{"id":"urn:uuid:db6f3f2d-6d23-403c-bfab-94c948bf407c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13785","original_object":"UniProtKB:P24394"}
{"id":"08645708-2577-44a8-b567-5d136213bd7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4085233","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:630c70a7-97ee-4c22-ade8-8b5df892f9c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10281","original_object":"UniProtKB:Q9Y210"}
{"id":"ac34f8db-6275-4d1e-bb8b-14504c20a170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433306","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:baaade1a-00fa-40f0-81e6-6f74fed80ca2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12804","original_object":"UniProtKB:Q9UBN7"}
{"id":"a243eeb6-c7d0-45ee-a4ed-5d88904b04b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:5aef74bf-0a7b-4156-a6f3-0cb4fe0c50b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q9UQL6"}
{"id":"d2ad50a9-5411-4775-b241-03f22674586f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192545","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:6be624a5-77aa-4e41-bc57-cf95c838786a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1394","original_object":"UniProtKB:Q14416"}
{"id":"76fc745e-5df0-4ad5-8f8b-b7ca81be5166","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:d13a9c17-5a2e-4e22-b957-a36c0fe28c59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P18089"}
{"id":"8fcb3b01-b4bd-4dbc-9ef3-5472103108d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2195","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:8987f5ad-8c66-4302-886c-b8697d48f08e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2195","original_object":"UniProtKB:P37288"}
{"id":"f6d465ca-4473-4dd3-8e74-d5939d39cfdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:915","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:059c23a3-f923-40e8-a412-9e20b3199b36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:915","original_object":"UniProtKB:P34998"}
{"id":"9eb42abf-3183-4dde-8ed4-070a7dbae52e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144947","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:4c2eaa6a-efd7-4dc9-827d-8c53deb38697","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10310","original_object":"UniProtKB:Q99500"}
{"id":"60cb71e8-a7d3-4548-8a48-95c2236ed7c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699442","predicate":"biolink:affects","object":"NCBIGene:5137","sources":[{"id":"urn:uuid:5826bb58-c259-4282-afe6-f36e5831ac85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11099","original_object":"UniProtKB:Q14123"}
{"id":"793892fd-c235-4018-abc8-c93b480e9e6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10143056","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:0101e714-b9a0-45af-a2e7-f4caa74b3c92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6742","original_object":"UniProtKB:P37231"}
{"id":"c066eba5-8fb9-498f-849c-801f124a866a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166176959","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:bea32faf-ba4a-4343-8c51-f0967ecd3b04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12311","original_object":"UniProtKB:Q13546"}
{"id":"8cbb15a4-e0ea-4959-8cbb-d14329fe790d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16144017","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:d2e12e9b-cfc5-48f0-a152-d87ce8d9cacb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1822","original_object":"UniProtKB:P25961"}
{"id":"b183f78f-ae5e-4fd5-83ae-3db5e33cbdca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:b1e10da3-54a5-4e1c-b5e7-352474cbb9f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P32305"}
{"id":"0acf7a5e-8444-4ef2-b7aa-2383920c8e5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16330","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:840e8430-af75-418f-a04f-701f88d6ef01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2856","original_object":"UniProtKB:P15207"}
{"id":"84f58fcd-a8f4-4326-bc76-a7aed036f148","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2219578","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:66a45ede-3aa7-4a52-ac23-a30e4bbfb889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7694","original_object":"UniProtKB:P35462"}
{"id":"8d2c0d58-b4d5-4b2b-81bb-0a3314169d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:54d9a054-26ea-4b92-9260-03965869ed39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P32745"}
{"id":"59e60463-6a0b-4c51-9eab-5ddbc002f68d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134457640","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:006c6717-2138-40fc-805a-cc71fdd189fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11114","original_object":"UniProtKB:Q5S007"}
{"id":"4709b7b3-291c-4ae1-9557-c0d7768a6bfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11079","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:46657b4b-1102-4f2d-9dd4-8bd238fe47f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11079","original_object":"UniProtKB:P0DTC2"}
{"id":"f5f00fee-e3a0-41f0-ae4b-82924e2eec8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78825","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:f194e2c5-d493-4adc-9daa-e7e6ec0bd6d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11867","original_object":"UniProtKB:P04049"}
{"id":"73b6131d-1616-4fe5-9c22-c15e4f913db8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10279142","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:0f209cdc-b9da-4e02-8da6-a2a5f3e06c4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1182","original_object":"UniProtKB:P30968"}
{"id":"82eb831a-3156-4e43-94e7-77210d41f33f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L9790S42AI","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:5e756226-8c30-4708-9828-9a81fa76d1f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11883","original_object":"UniProtKB:O60674"}
{"id":"455070f8-a262-4d7a-8f1e-7dd02b60c753","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9614","predicate":"biolink:affects","object":"NCBIGene:24953","sources":[{"id":"urn:uuid:8c6038ac-b3fb-4f08-bf6e-84ca3ffe2d74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9614","original_object":"UniProtKB:P30082"}
{"id":"3f07d56c-e67d-4c82-9642-6a37bbeb4a99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9058I8S63D","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:e8aeaaa0-e58d-4fb6-9406-2c2469e4d605","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8012","original_object":"UniProtKB:P48736"}
{"id":"95f19e2f-0926-4ffd-9499-5438eb036653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925550","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:e013a516-e4dd-47af-8cd4-6f8ac2e6d394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11944","original_object":"UniProtKB:P30556"}
{"id":"b3f40ddf-af2e-4092-af2a-3c79f20f6932","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:c998e044-cce7-4918-93fe-89fda6b2b4cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P28566"}
{"id":"93580ac4-78d3-4b06-bba0-6c83aaee7da3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91419","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:bc2ae328-2f24-468a-8ebf-cb97cb3812cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8473","original_object":"UniProtKB:P50750"}
{"id":"d26f41c6-fbe2-4771-ac6e-4099ccd1922b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124915","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:88b69355-06d9-441e-be46-7286149e36f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8477","original_object":"UniProtKB:Q13535"}
{"id":"9e0a6434-af88-496c-ac5c-147034559ea8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53869679","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:2138faeb-891b-4181-9ad3-dd284bf76fcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8795","original_object":"UniProtKB:P24557"}
{"id":"cfa86b7f-bd9a-4914-9d8b-89790525d78b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J64RI4D29U","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:3ce021f3-dbc5-407c-845c-f0c7095c6f15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11984","original_object":"UniProtKB:P09960"}
{"id":"5b141b2a-06f5-411f-9620-2695a010ae92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:152231544","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:cd2c9a3b-91b4-4e86-b4c4-689475fc13c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13221","original_object":"UniProtKB:O60674"}
{"id":"fe61bcc8-79b4-4af2-b752-332c7f237897","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:f477e3ca-78b3-4c44-9455-d718d3d85a0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:Q06187"}
{"id":"1f7018bd-c72e-42e9-b98b-3224d6016739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16122612","predicate":"biolink:affects","object":"NCBIGene:2101","sources":[{"id":"urn:uuid:600713d9-dfe0-4ebb-b045-00e25b31b375","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2833","original_object":"UniProtKB:P11474"}
{"id":"9c8b1dce-f771-4809-91e6-a5dcc21c3481","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95061","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:381a571f-31da-4604-8bf7-93616b89708b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8784","original_object":"UniProtKB:P36888"}
{"id":"3600fc90-d290-4fe9-bb58-e1f466c2ea47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:545eb87a-cac7-4924-aacb-6673522c4961","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P0DMS8"}
{"id":"c5bcac7c-b9d5-444c-b391-2c61f3857a77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4382","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:0ae444f8-6cde-453f-9e56-9a948c740b81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4382","original_object":"UniProtKB:P32246"}
{"id":"626ba097-c669-438c-a280-d438ab7b6174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:1fc17696-98eb-4a14-a26e-e2c18bf0ba3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P23975"}
{"id":"80b11848-4922-477b-945e-92f8a1a569b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:110693840","predicate":"biolink:affects","object":"NCBIGene:340024","sources":[{"id":"urn:uuid:8ac80c12-1eb8-46cd-b885-de84464181d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11229","original_object":"UniProtKB:Q695T7"}
{"id":"459d9c80-fd2c-47c0-beec-93c6c72beede","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57989460","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:6adf6c8b-4f19-4776-915a-580a11ce0331","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10699","original_object":"UniProtKB:P46098"}
{"id":"def6ad98-6b89-4d9b-9b37-4cea3824e890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1207","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:553f2086-93e4-4423-b981-e450b1b0915f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4089","original_object":"UniProtKB:Q12879"}
{"id":"e6a342a7-7bfa-4c52-816a-a67efe79d7a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:35F0Y2W16Q","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:fa911d69-80f0-4f18-8ca6-7f2c0eb6227d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8426","original_object":"UniProtKB:Q13639"}
{"id":"a287fe99-04a1-497e-928b-c983830572cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6804","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:b4dd85f6-e100-4107-abd6-eb0455be7a42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7438","original_object":"UniProtKB:P08482"}
{"id":"760f86eb-0205-450e-8de7-c4ec7a3709c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18026","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:5f1c43f6-3163-4e3f-be19-0fc9068ce045","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9809","original_object":"UniProtKB:P07550"}
{"id":"9b75f126-580b-485d-ba56-f25304cec8a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"UniProtKB:P04757","sources":[{"id":"urn:uuid:38a39b43-722a-4166-a726-53f37c8f95ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3976","original_object":"UniProtKB:P04757"}
{"id":"163d2a19-6cb6-4f28-b161-96333acd85db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92507","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:55b7e5fd-d9ba-41c1-9cc4-75504e04180b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:978","original_object":"UniProtKB:P30729"}
{"id":"12490f85-56a6-4aed-8c3b-a44a7f0af624","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177470","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:b3363ba9-69d3-46f6-9a3a-bb6d2f97a365","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1894","original_object":"UniProtKB:P43088"}
{"id":"2615c71d-bf97-479c-b6a0-3ae796669dda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:5b867d1d-7aaf-4a24-81f4-02c9be2a79dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P35462"}
{"id":"2223fdd4-b869-472f-bfeb-c2d5640f49fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:582124","predicate":"biolink:affects","object":"NCBIGene:268656","sources":[{"id":"urn:uuid:b6abe722-3749-466b-9103-6d912cde9f9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6664","original_object":"UniProtKB:O35704"}
{"id":"a746fb75-1df4-423b-9662-e7f7d14a5aa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13659","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:f03dcf24-2703-42a3-bb8a-b0780b8433eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13659","original_object":"UniProtKB:P0C6U8"}
{"id":"075d3519-10f5-4cb0-aa19-8eb8f9a0b6c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:a19e0f20-dd14-4dee-bb7f-369bf9d5f632","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q13507"}
{"id":"609cb283-607c-4d6c-8d4f-2c54dc11fbb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559100","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c3dbabfb-f8bc-4d9b-9099-070b1c5f6a93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:219","original_object":"UniProtKB:P28335"}
{"id":"440dfcb5-5f69-4014-9f2a-8eee30ce89f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UM3821998K","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:5655e56f-e3d4-404c-9ef8-abd300acf56d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3969","original_object":"UniProtKB:P36544"}
{"id":"62bbd00f-2e1b-402e-91d1-f66560d4ee47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92916","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:89e4b236-16ae-4166-9aec-813cfe20f602","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1922","original_object":"UniProtKB:P34995"}
{"id":"16358f43-7231-41c0-93a9-670883a01499","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67171","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:e06219b2-64e5-468b-afec-a9113c0847b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9885","original_object":"UniProtKB:P49336"}
{"id":"17ad4184-8ccf-468a-9ebf-f6c5c902713c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:916","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:ce1f599f-1ad5-41dd-84eb-b0a0fee78717","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:916","original_object":"UniProtKB:P34998"}
{"id":"47025f1f-dd29-4245-95f4-928d34ce440d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10047169","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:1cca4d50-e7c9-4bf2-bb75-7810fba70511","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1403","original_object":"UniProtKB:Q14416"}
{"id":"c5962695-0d46-4086-8b36-1f679bda8345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9903898","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:bb81e8e6-6fc0-4125-b34c-6ec122218d9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1386","original_object":"UniProtKB:P23385"}
{"id":"a520b5be-2a94-499b-aa3c-57cbf644ab8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135489238","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:fa9d3d9d-c4bd-43dc-a4f9-d65a663b7ab7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:381","original_object":"UniProtKB:P30542"}
{"id":"e92b7878-8e71-484e-a53d-92a36dada1f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8LEA6Q26BW","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:8e97a54d-037d-4a4f-93ab-d4bf5e0122f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3249","original_object":"UniProtKB:P28223"}
{"id":"8510395c-19f0-45b8-bbfe-7f5faca2c718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:34201c4d-21da-4639-8e46-c699bd118d3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:P00533"}
{"id":"56bf438d-bdff-411e-98a6-06cc3703705a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172333","predicate":"biolink:affects","object":"NCBIGene:4051","sources":[{"id":"urn:uuid:b14040cb-6a36-412c-8467-58da58329eba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11373","original_object":"UniProtKB:Q08477"}
{"id":"d18628b5-1c61-4335-8981-cbbb6b1bfc3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231352","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:a0d7da4f-5e03-49ca-bd2a-871eea1e33a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7502","original_object":"UniProtKB:Q9BY41"}
{"id":"4be31810-0b6c-4259-bd34-42188103d741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:3743","sources":[{"id":"urn:uuid:a4d8d775-9b88-4a12-b75b-45bf66570e3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q96RP8"}
{"id":"be23feee-d40a-4ee3-8289-596b4c061d04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136702","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:f7dca738-5a96-4ce5-878b-1b0359c12f12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6381","original_object":"UniProtKB:P00734"}
{"id":"2d2505c3-cd8a-4386-9c1b-b21b9d0b5ac3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90389","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:e3a3adda-c78f-4941-92ec-1b023b018ea7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1949","original_object":"UniProtKB:P21731"}
{"id":"ce4c49bb-bcb2-4acc-be20-bb3528d696a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2319","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:9215eb58-3fbd-4aac-ab6f-f5620ec45d67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2319","original_object":"UniProtKB:P70605"}
{"id":"d835ad7f-6235-443b-9556-72c3aca2e136","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:1494f07e-18de-4f51-9469-db73ac2e5701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:Q63447"}
{"id":"4c077b45-f61f-4f02-8cfc-5170257bde9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38126EQF7A","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:e6721130-a2b1-44b3-ad0e-58476aed498b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2288","original_object":"UniProtKB:P46098"}
{"id":"65052e6d-7323-4def-8974-021733e3fea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:ee138948-c622-43d7-9935-bd761a91d617","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P25100"}
{"id":"2e4f7991-ab1a-4ef1-809a-94624f8f5497","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:7067728","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:cff03939-347e-4b77-9e92-2b21eb8517a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1384","original_object":"UniProtKB:P23385"}
{"id":"a6e6dc85-59b6-4dab-aabd-a14acd5d338e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:9d2f0735-76ff-4efa-8256-f84c6a207bd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P34980"}
{"id":"9ebea7b6-4791-4067-a47a-b3778835d721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:04683561-4ace-4c1d-b5d4-184ec7755590","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P28221"}
{"id":"08f0c32e-510d-424d-a77e-db53a017c9c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:304827","sources":[{"id":"urn:uuid:a3730530-fcbb-45ea-9db9-7759bc5ff3da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q6UVM4"}
{"id":"ff6a579f-915e-4a56-bea5-d7ea900d171b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34952","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:85502de6-3ddb-4da6-9c6b-ca027dcc68e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4297","original_object":"UniProtKB:P31644"}
{"id":"f97c050c-57b3-4f8a-8f1a-11c1983fa626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50859","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:1267f907-71c9-4809-afbd-126f5f788a3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2807","original_object":"UniProtKB:P37231"}
{"id":"a61f4ab4-bce2-4fdc-a4a9-e2cd7d11a5b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46891047","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:eaf4b548-9c77-45d4-b539-e8eef8b17732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6212","original_object":"UniProtKB:P23385"}
{"id":"5ede6436-58a1-420a-95ed-0534587ebaa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28927","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:5df74de1-0b80-435a-aa9b-3536f9810652","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:412","original_object":"UniProtKB:P0DMS8"}
{"id":"adad5c01-7232-4a97-a606-1cac54b66d47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:bd2d4c9a-b6f5-4935-a12a-a42c03f9d94a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:P11802"}
{"id":"17753d00-e312-49ed-b59f-9fc3b82442ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321161","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:b13cc755-bf61-4aa9-8dde-b1ff70c4c2d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10177","original_object":"UniProtKB:P34972"}
{"id":"cfc18ebf-b9fb-4703-bb03-78cbaa1f441e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2273","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:804329be-2bdf-47a1-a6d5-e675082d60d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2273","original_object":"UniProtKB:P35000"}
{"id":"dbb26c29-ef3d-4dcb-98c0-11e8759e5b49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16264","predicate":"biolink:affects","object":"NCBIGene:171108","sources":[{"id":"urn:uuid:31d6ceac-698d-4a33-92de-1452687aa932","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1779","original_object":"UniProtKB:O35881"}
{"id":"9b58eb18-3cb9-4448-b0f7-c7aadcb9b359","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:61714c25-de44-4ce9-8120-74cf54f701ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P21917"}
{"id":"b2d9a635-91e3-404b-a921-87bb63af0b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167686","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:eecb367f-92aa-49ff-8783-1c5e6aefff76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5671","original_object":"UniProtKB:P11362"}
{"id":"b4f5ee32-9caa-4382-a6d5-434eb7c84ccb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131168","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:660097ff-2584-428c-932e-ac9ba6ffe40f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7890","original_object":"UniProtKB:P31749"}
{"id":"b31bae80-5fc8-4c2c-8395-a6df4662d157","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47426","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:73939146-73d9-418f-83f1-fbe48e11d134","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4839","original_object":"UniProtKB:Q16445"}
{"id":"ebd94e04-5148-4f7e-abf5-51ebf069ec99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92119","predicate":"biolink:affects","object":"NCBIGene:387893","sources":[{"id":"urn:uuid:b981c1c9-fe00-441b-b724-93213af73227","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5952","original_object":"UniProtKB:Q9NQR1"}
{"id":"f25d9dba-18a4-4c8f-9a4d-6b0218befa77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5631","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:2a4760eb-12d2-4aae-80b4-d776ead45a34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5631","original_object":"UniProtKB:P30874"}
{"id":"5edf9f8a-63e3-47f1-9d86-1e43cf24f492","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94038","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:668155ec-6f5a-404c-b074-4e2c5a17b5c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:300","original_object":"UniProtKB:P08173"}
{"id":"9dff4777-7008-49c4-8c1e-0eb682653a9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4513","predicate":"biolink:affects","object":"NCBIGene:79001","sources":[{"id":"urn:uuid:5f2630b8-6b3d-4bc2-8da9-ba81a7612200","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6808","original_object":"UniProtKB:Q9BQB6"}
{"id":"f68c2450-0fdc-4cfd-945f-8662918da806","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926513","predicate":"biolink:affects","object":"NCBIGene:1195","sources":[{"id":"urn:uuid:8ce3f7e7-8c2f-455f-99a6-b75b652efe1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8161","original_object":"UniProtKB:P49759"}
{"id":"1c533661-e941-4512-bdae-b41d77bcb092","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75272","predicate":"biolink:affects","object":"NCBIGene:23411","sources":[{"id":"urn:uuid:9b023e4b-bf22-4201-81e6-eab46f24e3ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8101","original_object":"UniProtKB:Q96EB6"}
{"id":"8a64a36a-122e-4559-9f7e-d3b9bf0a0ad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67237","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:5da06a9a-076b-417f-a3be-7fe0fb403fec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2742","original_object":"UniProtKB:Q96RI1"}
{"id":"c5e55151-ff08-4da2-8863-136f7d7150cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28774","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:9b3c9781-6d1c-4a41-abf7-2e339dcddffb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2636","original_object":"UniProtKB:P10827"}
{"id":"d0d1f375-c38b-401e-b5ec-6f5d207fde3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4315","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:5a1c476e-2e35-4e60-b24a-694eadde4867","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6942","original_object":"UniProtKB:P15207"}
{"id":"cb6a1aab-342b-4355-8a2e-d47667834a3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030531","predicate":"biolink:affects","object":"NCBIGene:259249","sources":[{"id":"urn:uuid:6ee2ed56-9040-4359-9de4-e67ddb57769b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10482","original_object":"UniProtKB:Q96LB2"}
{"id":"71fba470-d770-4e00-a656-e29d1a0913b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:6096","sources":[{"id":"urn:uuid:6b9cbf6b-783a-49af-965e-16e42013dc41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:Q92753"}
{"id":"4c8d8401-6ae2-4a70-b5d4-c9fb3981a820","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441296","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:14f880ca-9626-4934-97fc-5cac53907e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1864","original_object":"UniProtKB:Q62035"}
{"id":"79e85652-1424-4552-9e0f-bc39365b6c00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13816","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:3377674c-08f0-4a04-bbaa-cda85b294485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13816","original_object":"UniProtKB:P21554"}
{"id":"50addfe7-2c02-4523-9546-63997df36b91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16135415","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:36850eaa-3f36-4c27-ba85-660505a45331","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2536","original_object":"UniProtKB:Q02294"}
{"id":"e2a6945a-12ae-4d9b-8847-513742c488ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23643135","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:135d5834-12a1-4649-bb62-5d3c1bee6b0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3974","original_object":"UniProtKB:P36544"}
{"id":"bf89de49-cebf-46df-bc10-057a3441d470","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:a3980c18-5480-43e2-acc7-b27440259c08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:342","original_object":"UniProtKB:P08172"}
{"id":"ef15e5c0-a0b9-4561-8955-ce9febec1d20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64122","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:39479f52-970e-4cd7-88f7-6cab67767805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:960","original_object":"UniProtKB:P35462"}
{"id":"a51c6701-df5e-4ed2-9477-e3536d4f6b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80127","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:fb9a63f4-ffa0-4a17-b61a-9af759189442","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5368","original_object":"UniProtKB:P30556"}
{"id":"07d424b0-41b7-4bfc-b4f6-e61e4ea363fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9810140","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:34f874be-fb46-46f2-802a-fa6715b51941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2205","original_object":"UniProtKB:P30518"}
{"id":"2b401ade-443b-4688-86fa-0b99ab2975bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9449","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:3135db57-238c-400c-adf3-91eee7aeb9c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:560","original_object":"UniProtKB:P08588"}
{"id":"4b59cc0b-851a-4414-9286-98fe7968cc01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:b43b9fb5-c2ea-4059-9e16-86129a0fb4ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P34969"}
{"id":"e586ad8e-84d2-40c3-873a-1af31e0f81a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311016","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:40a715de-e82f-4c5a-9113-1f326618dae9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:897","original_object":"UniProtKB:P30553"}
{"id":"536a3c59-7604-43ea-9db8-74abc5763b7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:175064","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:da6443dc-a972-4989-989c-501e1b27750b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2606","original_object":"UniProtKB:O95259"}
{"id":"d2e4a522-a71f-4382-9006-a6cbaa99f13b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8887","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:4af0806e-14f2-4a27-8f15-451c4c3b819c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2893","original_object":"UniProtKB:P35354"}
{"id":"70ee35aa-7dcc-4475-ac52-202fe03986b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192264","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:95eb91f2-80bc-40eb-abe3-90f38b117da9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2073","original_object":"UniProtKB:P32745"}
{"id":"02b284ea-6307-46ab-9f93-e4e58d591948","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:313639","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:7003c9f3-f766-42dd-8ef1-098097f8c2a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7181","original_object":"UniProtKB:P10980"}
{"id":"ef2f85ff-9f17-4b41-a0a1-29526a01e0c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2LHZ9ZC3YO","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:25f61e36-50c7-49f7-9287-f931797699a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12704","original_object":"UniProtKB:Q13490"}
{"id":"7b691fae-2c7c-4752-8f20-323137e48501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:6789","sources":[{"id":"urn:uuid:ec60559c-49c4-40a6-9ddf-ab0ba59fc4e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:Q13043"}
{"id":"61b0f5ca-0348-49d6-806a-af61e37a140b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2381342","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:814ed6b6-14ce-4623-afc8-617f55f982e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9380","original_object":"UniProtKB:P36897"}
{"id":"982196e4-7fe3-4288-aca0-3684b4c5f4c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:6afe232f-def8-4206-b50f-d630c06c95b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P35916"}
{"id":"a4e6a931-d6d8-4b57-8ac9-9918d4865097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6110","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:181d89a0-64d8-4b82-8339-54f809776d4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6110","original_object":"UniProtKB:P47211"}
{"id":"fcf67392-ca4f-44da-a838-1691304386ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:1607d57d-2688-42ef-93e8-fffa625aed4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P52333"}
{"id":"f27b0332-ab7c-43f6-88bf-fc7fa993953e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10500941","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:47a483a8-206a-4b05-b64a-1b29e3c0118d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:393","original_object":"UniProtKB:P25099"}
{"id":"196d1f8c-22e2-4eab-a4d7-a075f923ada9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4850","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:9ce1bdd9-5889-4260-9278-89f8c386f122","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4850","original_object":"UniProtKB:P25092"}
{"id":"ac1709d0-e0d1-458d-a164-0627b2405a1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91455","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:dd125d24-c24e-4498-809e-d36370822143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5192","original_object":"UniProtKB:P05129"}
{"id":"02f3acb8-532e-459d-98c7-9274630ce852","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46192505","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:3496dc1d-10c3-47f1-9766-bdd9cb5b2dda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8117","original_object":"UniProtKB:P53671"}
{"id":"be406dbb-2382-4710-b2c4-a31eccd3b5ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129053583","predicate":"biolink:affects","object":"NCBIGene:266632","sources":[{"id":"urn:uuid:33c1052e-70c9-497e-94c5-97708caaa100","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12510","original_object":"UniProtKB:Q8R4K2"}
{"id":"f28ac97e-e098-441f-b8db-7606c2fa1c21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:5c930252-cc43-4e66-a331-669eeafa9d84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P30994"}
{"id":"041317c3-76a4-4409-adc0-fb40106932ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:69a6842b-29a5-45e6-917e-fbb2d0620f21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:P34980"}
{"id":"02af6633-b7ec-45a7-a0d6-99cf78351894","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118356682","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:ead15cd1-9573-427c-ac6a-ba327679e5ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11193","original_object":"UniProtKB:P51813"}
{"id":"ae39e7a2-8a49-4544-8873-8bc30c9cc7e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5122","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:e4cb1f9f-4b92-4acf-9863-30633067e8d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:279","original_object":"UniProtKB:P50406"}
{"id":"67af685f-93fe-4e97-bf52-f2fafac99ba8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321160","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:ffa51620-d4d4-415b-8097-181b070516b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10157","original_object":"UniProtKB:P29597"}
{"id":"9b781750-8063-4ea9-b1b9-f180d7a18113","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9YA9HD8JR2","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:2a2403ce-7234-453e-9f96-80a334df4148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7659","original_object":"UniProtKB:Q12809"}
{"id":"909baa69-6559-4c65-9f4f-bac7655c1f43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28955","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:5986f2d7-b150-43d3-ae56-b4b60408612a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12058","original_object":"UniProtKB:Q99527"}
{"id":"06cd596c-ff5e-41a7-a072-4672392b1789","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:19511","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:0c3ccf20-53d2-4843-a738-4c94b3004257","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2910","original_object":"UniProtKB:Q9HBW0"}
{"id":"1463030d-9d42-4036-963c-b86555db05fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2814","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:57ad35bb-22b2-46e8-8d1a-dd6c2b70aa17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:296","original_object":"UniProtKB:P11229"}
{"id":"522ffe47-dd34-4435-802d-748cc037bfdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:68150065-d172-4501-9dce-75723fec9ea5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P10721"}
{"id":"3a03bb85-06a5-4cd2-86a2-578ca9393400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170991","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:29d12e92-2646-4e78-8847-2adc58630851","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10740","original_object":"UniProtKB:Q92847"}
{"id":"6703566d-4e96-4d9d-a1d1-09cb5eb5f824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5019","predicate":"biolink:affects","object":"NCBIGene:7099","sources":[{"id":"urn:uuid:868002cb-7577-42c5-9a7a-e40b24362a4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5019","original_object":"UniProtKB:O00206"}
{"id":"60e73c24-c907-4fe2-985e-9c59a14dd559","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZK5NA2M82J","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:7d4befae-a417-42a2-92dc-333da9bef34a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4299","original_object":"UniProtKB:P47869"}
{"id":"38feffed-cfe4-4518-bb4a-0657cba7e06d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3131","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:2b5f6456-91ad-481b-804a-d33d3615488c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2338","original_object":"UniProtKB:Q6IQ20"}
{"id":"ea0a21d8-aadd-4f5b-b690-734f4088195a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121334520","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:93ce2cbc-69ae-475d-9131-5603ea86a18b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10142","original_object":"UniProtKB:Q8NEB9"}
{"id":"01c4c575-24a6-490b-adc2-844639536e3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:2444","sources":[{"id":"urn:uuid:a0d987d4-6a03-4f92-b67b-f57006b970b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P42685"}
{"id":"7e928472-9c23-4421-aca7-50a60a738196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46175162","predicate":"biolink:affects","object":"NCBIGene:4323","sources":[{"id":"urn:uuid:15233c7a-9053-45ca-9366-bf5f0f75fa5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8578","original_object":"UniProtKB:P50281"}
{"id":"ce5479cc-c66d-4f95-ab39-991b8af0d48c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10100","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:69044168-daaa-4686-bd76-80493d01ad5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3322","original_object":"UniProtKB:Q9NS75"}
{"id":"bca5b470-6dad-44d1-b79f-d4931ca053ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45980","predicate":"biolink:affects","object":"NCBIGene:12669","sources":[{"id":"urn:uuid:36166223-bab7-4cbb-89c0-7e339c4cf2cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6687","original_object":"UniProtKB:P12657"}
{"id":"e4807b47-7df9-42ea-99f3-3497877b8a1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:259232","sources":[{"id":"urn:uuid:54d075ad-5894-479d-a663-d29ad610fab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q8IZF0"}
{"id":"adecbc53-6c12-4902-9348-62c3f98979b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4023","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:84aa52b7-6c20-470a-950d-76b860d1bd38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4088","original_object":"UniProtKB:O15399"}
{"id":"f7a16317-5e00-467d-be5c-699a1828669e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68060125","predicate":"biolink:affects","object":"NCBIGene:5063","sources":[{"id":"urn:uuid:3f43da07-5f6c-44d6-9922-409af3e2d5d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8938","original_object":"UniProtKB:O75914"}
{"id":"12b00571-aee9-4851-90c7-37eb0c2144fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:582124","predicate":"biolink:affects","object":"NCBIGene:55304","sources":[{"id":"urn:uuid:01875a37-952c-46eb-8932-a9fa91b64489","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6664","original_object":"UniProtKB:Q9NUV7"}
{"id":"b29687ac-feac-4630-9957-f2082cb6e273","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155190269","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:da08679e-9a4b-4cbf-bc44-9084579263ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12357","original_object":"UniProtKB:P16234"}
{"id":"fa51c4ef-927b-422c-831e-716b184bdf82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4206","predicate":"biolink:affects","object":"NCBIGene:7220","sources":[{"id":"urn:uuid:6a47c2f3-1951-41f7-adcb-c2a48569a58a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4206","original_object":"UniProtKB:P48995"}
{"id":"06225fdc-79aa-40c1-aed5-4a8169dd606e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080554","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:b5742bdb-3b14-4bdc-a40c-65e2bd1932e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4216","original_object":"UniProtKB:O15399"}
{"id":"5e5919f3-1e80-4e53-9295-66b8fa2f6e53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656767","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:71459e6d-d643-460c-99b9-e9fae5ff1b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2558","original_object":"UniProtKB:Q17ST2"}
{"id":"597b9fc4-50c6-4d19-9c54-0021a8567433","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993652","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:d073b0b2-bd59-490e-a133-ee9f7e08fe90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12537","original_object":"UniProtKB:Q9NZQ8"}
{"id":"bc38cc20-7492-4153-9ed8-9c8e65bba2f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:0e5293f0-8ce8-4561-89fe-33d9f8045517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P35346"}
{"id":"8d686d6b-ea2c-4d0e-93d5-db5d8e6b8bc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101205709","predicate":"biolink:affects","object":"NCBIGene:64636","sources":[{"id":"urn:uuid:f7b6312d-0544-4ac5-8f23-ce77b22fd75d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1573","original_object":"UniProtKB:Q63384"}
{"id":"86ce91ca-0c3b-4294-bcbc-a55404d9090e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92215","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:f8ce4227-170a-4b53-8083-cab2ddd13c9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2919","original_object":"UniProtKB:O76074"}
{"id":"498aca43-e8ef-4755-ba7f-c812377f5508","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31625","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:49863f66-cb42-4a0c-9a16-8592bebdd4fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7079","original_object":"UniProtKB:P04150"}
{"id":"1a87867d-131d-4d8c-ac9b-2c8b0a5e2207","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1029","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:e47ea6fa-1771-49ee-8f38-8e371e9d3d8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1029","original_object":"UniProtKB:P21462"}
{"id":"3abf7d6f-22d7-4d5c-87aa-9a653f729ebd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G2283XQ6VJ","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:f63c94c1-e0ab-47d2-ade2-5d05f5232df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8469","original_object":"UniProtKB:Q8TDS4"}
{"id":"a9375f74-facb-4794-af45-02765613e87d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71727668","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:e98c2197-bef1-4fd8-85be-d564b4ac9ceb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9803","original_object":"UniProtKB:O60674"}
{"id":"3499339b-ba35-4dda-98f1-4a13caecda8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:932c0995-fc50-440f-84cd-ca4b324b001f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P18825"}
{"id":"7bcf8653-94e5-4100-81a2-d4106815877f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17347","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:173dc35d-504c-437f-911f-b4ea94946cab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2858","original_object":"UniProtKB:P15207"}
{"id":"c13393bb-4800-4052-92e3-7593193183ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156071569","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:dae78eea-f37f-4f5e-ad29-b3a949c51ff8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13371","original_object":"UniProtKB:P00533"}
{"id":"d60309f2-54aa-4e1a-863e-5a15a0a8760e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:181254","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:b3f71513-b0bb-4673-9ad5-2632eded4403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8701","original_object":"UniProtKB:P37231"}
{"id":"212b6e79-1e1b-4319-a626-4ca157d17bf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92984","predicate":"biolink:affects","object":"NCBIGene:747","sources":[{"id":"urn:uuid:4c9012ac-9373-4098-9cb7-757e7f95dabf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5255","original_object":"UniProtKB:Q9Y4D2"}
{"id":"2cfe9e05-bf27-43f1-864a-07edb9b282a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9875034","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:352f20a5-39c2-462a-b736-4d968652489e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2106","original_object":"UniProtKB:P25103"}
{"id":"72329e9f-b112-407e-b2d4-ddb2c0c8f217","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93239","predicate":"biolink:affects","object":"NCBIGene:23135","sources":[{"id":"urn:uuid:87c53f37-3128-471e-8a06-09d42662b6d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8230","original_object":"UniProtKB:O15054"}
{"id":"b817d1cf-450f-44b9-b9f1-ad788cc52dd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154642303","predicate":"biolink:affects","object":"NCBIGene:56749","sources":[{"id":"urn:uuid:0b361682-0933-4e37-9308-d2a0db6f7f64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12105","original_object":"UniProtKB:O35435"}
{"id":"08116116-cf32-429f-a4de-26c324ce2176","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:c1c1d212-8e21-4062-93e3-96a7c451ea60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:O95136"}
{"id":"1927582d-8062-4c21-8915-70bb694b52ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11989776","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:a9d562db-8f70-4bed-aabd-a0482b0f6a19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2130","original_object":"UniProtKB:P29371"}
{"id":"ad340bb9-523d-4778-b1d1-416649c4981c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:8324dfde-beed-4dd1-95ce-e511736e0557","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:Q14832"}
{"id":"2674e7cb-6a38-4910-aff9-6cf4ce27cf93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46836872","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:28b7e16b-b7ef-4cc8-82da-740206fc633b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6238","original_object":"UniProtKB:Q14833"}
{"id":"aa1d9581-4eef-475f-8fae-bbd23edc9410","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71816200","predicate":"biolink:affects","object":"NCBIGene:24174","sources":[{"id":"urn:uuid:260ed8c3-39cd-4e21-a584-a84ac4459f8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13181","original_object":"UniProtKB:P19328"}
{"id":"1d58ebd8-e493-4425-8d88-aed61133dcd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51230","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:2e6a42fe-284f-488f-84a7-4fbab50fd3f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1958","original_object":"UniProtKB:P43088"}
{"id":"dcba7ace-2f02-459d-90c5-a6aa81a23536","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17148","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:ec273285-6904-4395-91df-17c80ab776bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2388","original_object":"UniProtKB:P48050"}
{"id":"ecd75830-7dc2-4523-ac8f-ed0f94e70b21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8P2T76M0SJ","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:afa74737-5556-4b1f-8131-c85dd7a4293b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11454","original_object":"UniProtKB:P37288"}
{"id":"d7450922-c4cb-44db-8c71-b2f0bfacba54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177856","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:a43577cc-a4cd-4517-ad34-69f240f83a7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9341","original_object":"UniProtKB:P30968"}
{"id":"96b119bb-fb49-4991-b239-02c449cabf9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3972752","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:d3bb9624-8b30-4ca9-aebb-cbd864fd4d20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1415","original_object":"UniProtKB:O00222"}
{"id":"4aa69810-6bdd-4f97-b7ae-d3a40eccfa7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135935","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:203fb9fb-231a-431c-b6ab-d416f4c0e4af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7477","original_object":"UniProtKB:P23975"}
{"id":"4c554c6c-199f-416f-bcc2-854febefafcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:1a2f5084-3c85-4aa9-a84d-4eda6b7237f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P32745"}
{"id":"9fc3e86c-7a79-4453-9db9-59db3fbf4a79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17759121","predicate":"biolink:affects","object":"NCBIGene:57406","sources":[{"id":"urn:uuid:04772a25-b555-4007-a428-5200a96bcf30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5289","original_object":"UniProtKB:Q9BV23"}
{"id":"c85ee1ba-22ac-4e3d-bd9d-f8afa076f2b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9571","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:3a5602b0-c83a-4b04-939f-66abab1968f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:212","original_object":"UniProtKB:P35367"}
{"id":"557b686d-4b4b-4689-b71c-6efd26af17af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53364540","predicate":"biolink:affects","object":"NCBIGene:57406","sources":[{"id":"urn:uuid:a566f66c-8be4-4d8c-a2c3-b47e19c59eb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10245","original_object":"UniProtKB:Q9BV23"}
{"id":"2955b281-30ac-4a8f-8aff-5bbf126c182e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91418","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:53f24b27-8de1-46e3-8a4c-9b6304b9b8bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5679","original_object":"UniProtKB:P08581"}
{"id":"66b67a68-4d99-4dd5-821b-03998f7d700e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151447433","predicate":"biolink:affects","object":"NCBIGene:23235","sources":[{"id":"urn:uuid:05d3c6e2-7395-4115-b565-ad8fa89ad5c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13303","original_object":"UniProtKB:Q9H0K1"}
{"id":"d4f823c1-bb23-42e9-addd-037535fbb130","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:b8ec651f-9509-4da8-8669-0133be14a14f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P32304"}
{"id":"006e354b-3d37-4cc2-bd3e-e82320c16a09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817483","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:5f4d4ec5-2201-4151-b9c2-363321a2f90d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6094","original_object":"UniProtKB:Q62805"}
{"id":"74fb5646-1947-46c8-8574-837e72c80980","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:3dee6428-9c02-434f-81b2-4f104910faaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:O95835"}
{"id":"334457fa-0876-44b4-b5c3-7437067e9c54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:07aad1e9-859f-447d-99af-7d712a60cf10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P47869"}
{"id":"2dac8fe4-e25a-41c1-b061-081359eea551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:f0739039-2d37-4701-8c41-0f4f1da75727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:P18825"}
{"id":"b3142056-e8a3-47af-9ac5-eaf9c9b9ff6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42111","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:bbffbec3-b8ec-468f-a5b2-502c941e45bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2934","original_object":"UniProtKB:Q9BXC0"}
{"id":"166c24bf-3c36-4a1a-a34b-8c6df11e411d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9824507","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:7a59ec94-136e-4dd7-ad9c-f318faa50002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1920","original_object":"UniProtKB:P30557"}
{"id":"5ecd28b1-ccc2-487c-bd0f-6f615b1d38cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4345065","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:573181d3-7733-4255-8bfb-00255009545c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1093","original_object":"UniProtKB:Q92847"}
{"id":"0ac4558d-b48e-461a-895d-0fcfaee970e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131648253","predicate":"biolink:affects","object":"NCBIGene:14608","sources":[{"id":"urn:uuid:17e03541-9167-45a8-9441-df99ba3c93be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9139","original_object":"UniProtKB:P30731"}
{"id":"e56ca8a4-c518-4d54-b712-779a09cb28ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:abb13a56-a8af-4c98-a1c6-71563f9c9a42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P32305"}
{"id":"d6c525f4-d26c-4886-b305-129759f939af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2275","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:21fac2c2-70f8-4d59-88c7-f1e95128cc75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2275","original_object":"UniProtKB:P30083"}
{"id":"3437240b-1e56-4081-9b99-4f7db96fcf47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:e37f54cd-1d50-44b7-91dd-f07708cb6093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P07948"}
{"id":"5f601385-2325-49f9-8f1d-9a31bea67742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91810","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:96a3833a-aa80-4a59-a55a-a60b5228c146","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:245","original_object":"UniProtKB:Q13639"}
{"id":"93f29d23-f09a-42a0-9ddd-fa97b56ebdf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072557","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:2235d9d8-254a-4c96-ba47-99699a8622a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9000","original_object":"UniProtKB:P23219"}
{"id":"46c0c5c3-1c96-4c04-8015-fdf3b779b914","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311190","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:e1887f7f-d7ea-4229-94e5-fbb9eedb241e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:957","original_object":"UniProtKB:P61169"}
{"id":"1567d574-582c-44e1-9e14-e44df3a89029","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3112","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:11df5581-4172-4c79-b571-55bd1374f7cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7128","original_object":"UniProtKB:P08912"}
{"id":"6f386a1c-487b-433a-b8b5-b2f94a2ae847","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LF333FK2V5","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:20b02de3-0d59-4e8b-88bb-547a43390e5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11678","original_object":"UniProtKB:P07949"}
{"id":"5dbd6e92-14f6-4770-8a6b-d0337fef0d53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118356682","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:3760f998-e261-48b5-8da5-641b52cab5a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11193","original_object":"UniProtKB:P42680"}
{"id":"84ea53a5-02b6-4f86-9219-0cfeaf22bd16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2702","sources":[{"id":"urn:uuid:eab1aa8e-c785-4299-a5bd-0c4c8d058d26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P36382"}
{"id":"db92703b-eba2-4b92-af6e-27fbe80f7864","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:53O87HA2QU","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:4b7be16a-aea3-482d-b018-cf3affef5b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7910","original_object":"UniProtKB:O95835"}
{"id":"513b337d-e858-4d3e-b52d-f7b1787f945c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:4ab273df-93d2-4529-ba64-00d6e12c8437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P28221"}
{"id":"91331dd9-038e-4595-9eed-074abc45f9eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:25a4eb7c-8439-4275-903a-31605f7fa33d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:Q13547"}
{"id":"f41dee61-2fa7-44a1-826c-0ce0eb5e8337","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9696680","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:1df200db-61d8-4840-b05d-900a83707d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9457","original_object":"UniProtKB:P55085"}
{"id":"756a2976-531a-4334-b585-f6649c4b3ecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1296","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:190ad8eb-67a9-4754-8fce-228cb873a818","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1296","original_object":"UniProtKB:Q99705"}
{"id":"4f77543d-e27a-4ceb-9c92-4df0a191db98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94573","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:23ae113d-29c4-4a60-9f81-68dc306f0bc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3539","original_object":"UniProtKB:P25101"}
{"id":"0b0cce91-0655-498d-99b9-f8a605e10548","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13796","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:f60fe6c8-47e2-470a-a346-4d55b3dd2182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13796","original_object":"UniProtKB:Q15116"}
{"id":"98f27401-b3f0-41ab-a168-ffd6c45ffe99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:b7b38809-d983-4713-b45a-1cbd68cb58cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P30874"}
{"id":"14d0365b-c16e-45bd-abf4-314e09a5b557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94504","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:05120e36-457e-414e-aef5-90e9746cf037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8464","original_object":"UniProtKB:O15379"}
{"id":"3e8c8702-5de8-47b5-ad24-00d5a39660ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4952","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:ec63c6df-de25-46c4-85f3-2071971f506b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4952","original_object":"UniProtKB:P20594"}
{"id":"df5cfafc-da5d-4ee1-add8-f78a4ad41f8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817424","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:ce9ec93a-7d47-4f23-8750-a1659a7eab7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1551","original_object":"UniProtKB:Q63447"}
{"id":"c756eb9b-a795-4d5b-86da-f489a5347e35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P89BJJ8QAR","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:0ff9da9b-786d-4ae4-afc1-786a2fab7620","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1563","original_object":"UniProtKB:Q15761"}
{"id":"8193649e-21ed-43b6-927a-581080a65457","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44737","predicate":"biolink:affects","object":"NCBIGene:9682","sources":[{"id":"urn:uuid:e1e54126-9e38-4fce-81b2-086d6f2cb928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8744","original_object":"UniProtKB:O75164"}
{"id":"631b9bdb-0c42-496f-a167-508e147236b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53393127","predicate":"biolink:affects","object":"NCBIGene:9572","sources":[{"id":"urn:uuid:42198818-7a9d-4fa9-b301-47d434038ea9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2904","original_object":"UniProtKB:P20393"}
{"id":"5ad7a6d5-f951-4552-b3af-a289b50a8e59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78357766","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:46642d29-96c7-4d71-ab0e-65bfa57619be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8977","original_object":"UniProtKB:O60285"}
{"id":"aefadd21-8eb9-4ec0-b98c-2ab0ff4f9a7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311504","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:5a28e485-4602-4253-b0d3-a19abc6b1314","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3448","original_object":"UniProtKB:P08235"}
{"id":"6031f35d-701e-4a7b-9ff6-73dbe36bfe0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2277","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:23d89df6-ba96-443f-b9c9-dac54ce8f457","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2277","original_object":"UniProtKB:P32241"}
{"id":"d0189445-0eb7-427a-a9c6-ad2b15f44b4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138674003","predicate":"biolink:affects","object":"NCBIGene:55936","sources":[{"id":"urn:uuid:95e2a925-dfe8-4bab-8a01-d5f90ba487c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12314","original_object":"UniProtKB:P70303"}
{"id":"955470fd-34a4-446a-9eba-3d295860c7fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:16516","sources":[{"id":"urn:uuid:991de3e2-dd92-4f3a-91b0-fa921c9ba53b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:O88932"}
{"id":"eebbc792-627d-4089-b36d-f763ea44c8c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D8UW47H17B","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:e7b9dee1-f42c-4e81-b583-4e9aef48c936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1379","original_object":"UniProtKB:P23385"}
{"id":"8b29f2b1-3d0d-4eba-8ac6-ccfaeb207739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94355","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:88126e77-00b2-4b06-8a25-08359e907a1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8311","original_object":"UniProtKB:P11511"}
{"id":"0eadb203-63d0-4f8c-a9d3-a9b2a1faa00c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:10af4f21-2897-4808-9e2e-ff95de3171c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P08912"}
{"id":"e919d604-c1e3-48a7-88a3-ceb09ebae73a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:178199","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:f37a23ed-1962-4542-99dd-07dd339f5cf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10678","original_object":"UniProtKB:P01116"}
{"id":"3e864fd8-67b7-47a6-8625-2d3c0d6f77eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:378807","sources":[{"id":"urn:uuid:c8b0a124-9fd8-4517-945a-87adc369b5f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q7RTX7"}
{"id":"16f4c433-5172-47c7-b145-a6613b7f74dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146637574","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:5a793cee-f5d1-4749-ad15-37f25664fad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13958","original_object":"UniProtKB:O95835"}
{"id":"c7d8e9c2-6ec4-4357-b09b-ebbccf65a432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4206","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:fe2e71ff-a35f-4c71-8973-1b70a4e4b2bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4206","original_object":"UniProtKB:Q9Y210"}
{"id":"a1f23f83-461e-4fdf-83b3-9570891de930","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56951318","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:e00e34ce-c9ee-41fc-974f-e9e25cb3fe5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5733","original_object":"UniProtKB:Q15858"}
{"id":"065de06a-a51f-4f6d-b54a-24550044100f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68299673","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:8e2a0cb4-781f-4cf6-8c74-2826e5c991fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13743","original_object":"UniProtKB:P31751"}
{"id":"0e9d485d-51be-43bd-91c5-ff00df5c79da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2009","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:a1235b70-a913-4945-b756-388b2b13e241","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2009","original_object":"UniProtKB:P30872"}
{"id":"c8ff8f45-d64d-4af5-91d3-37b5e4a55322","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6539","predicate":"biolink:affects","object":"UniProtKB:P15823","sources":[{"id":"urn:uuid:2b7d3189-edbe-4d02-8855-60743f5769ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5884","original_object":"UniProtKB:P15823"}
{"id":"64d5253e-755c-418b-9e03-cc738432f626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:65c09026-dade-44bd-8ba5-49831c763097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P11229"}
{"id":"fa1bebb7-0f98-47e1-a0fc-d218ee41949f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10304","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:db8fa806-8278-45bf-92de-93a767e00d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:508","original_object":"UniProtKB:P23944"}
{"id":"25aba593-0b5d-4ac2-b730-75bc270e7018","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41774","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:47d71889-eacc-4da4-bef9-ab33dd29c9a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1016","original_object":"UniProtKB:P03372"}
{"id":"df6181c2-1172-48d8-a2cf-ce5b6ca97d56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:2899","sources":[{"id":"urn:uuid:0acaf88a-7d55-4e63-b197-22af758c500f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4075","original_object":"UniProtKB:Q13003"}
{"id":"e30d8074-72ec-41ec-98e1-1799ead8f712","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9140","predicate":"biolink:affects","object":"NCBIGene:14608","sources":[{"id":"urn:uuid:7848dc41-76de-47bd-b1c2-7440b4e01c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9140","original_object":"UniProtKB:P30731"}
{"id":"7c8ecb24-d98f-46bd-8458-52fd34a2b8c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44222958","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:f0af0821-cca0-4b9b-b4f2-971715ecf5a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8214","original_object":"UniProtKB:Q9P1W9"}
{"id":"ed737e3f-f288-4661-91a9-f63a4cbff442","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5487427","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:b7171df4-939e-462b-ad52-2678e9f48957","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:367","original_object":"UniProtKB:P08173"}
{"id":"ec2c48b3-1d30-499a-929b-bdc2c7e7d604","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817489","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:e94918e5-3410-4790-bba0-0d3f2e6f18c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6166","original_object":"UniProtKB:P30550"}
{"id":"a8a5d195-6ed7-4a28-b207-0854051eba89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11675054","predicate":"biolink:affects","object":"NCBIGene:8814","sources":[{"id":"urn:uuid:6cf0f0af-04e8-4aa6-aa8e-76fb57ba8b47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8160","original_object":"UniProtKB:Q00532"}
{"id":"30ecf5e8-fb92-44c8-b12d-3d07504c5df6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140524","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:d9777a02-c9d1-4c40-a418-dda1ca33160a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4205","original_object":"UniProtKB:Q9HBA0"}
{"id":"aed01f8e-c3a1-456a-a6fc-5259c8980e00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34952","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:a28bbd4e-2fd8-43fd-9dae-b914380ac5cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4297","original_object":"UniProtKB:P34903"}
{"id":"cf5a3aa6-281f-4f35-b354-391d84c87641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133801","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:8c0c3410-dc95-4e2c-8ecd-bb36fc1f4dd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3859","original_object":"UniProtKB:P24530"}
{"id":"196419d0-cb85-49d8-88e8-0c8774e6b8c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156612914","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:427547a1-8dfd-4e61-adbc-a5c7140d24e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11751","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"1a3ea768-76e9-4c92-9e76-c2d149501106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2278","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:04d40e3c-5aed-4f45-9bff-b222073b45c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2278","original_object":"UniProtKB:P32241"}
{"id":"44e0428f-b5f9-46aa-93d3-5bc54c633ded","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2K2UE2I8AY","predicate":"biolink:affects","object":"NCBIGene:5409","sources":[{"id":"urn:uuid:ef8120be-6262-4f33-a0fa-fc67d0524879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6631","original_object":"UniProtKB:P11086"}
{"id":"6e0a0563-8ffd-4b32-adcd-d79330db09c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197013","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:8db62417-ac4e-4fad-99ba-f49682b04321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5526","original_object":"UniProtKB:Q14330"}
{"id":"7bc14321-d028-4aa0-8322-432e4a9fe511","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817490","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:61f62b66-aa81-4645-b2b7-d8b2b4a4351f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6168","original_object":"UniProtKB:P24053"}
{"id":"7cb2bc8d-bd5e-4639-9f82-82f2a187bbb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312112","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:05b58533-1593-4df6-b178-8da293a05b49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:415","original_object":"UniProtKB:P29275"}
{"id":"433e8b8e-60b2-4d3c-959e-bdfef4522157","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15996","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:65560d99-ec73-487e-b2ef-0838874a3a0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1742","original_object":"UniProtKB:P97794"}
{"id":"480a90cc-33c3-4eb2-9bc1-b3e71814aa01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3342775","predicate":"biolink:affects","object":"NCBIGene:8694","sources":[{"id":"urn:uuid:d3da2af3-32e7-42eb-90c7-b2a53ba5708c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7831","original_object":"UniProtKB:O75907"}
{"id":"29a5ffe1-523e-4775-89b5-51c782d5797a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49836087","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:4e468091-ece3-4e9a-bcbb-10d2e5c102fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6222","original_object":"UniProtKB:Q14832"}
{"id":"1943055e-274d-499f-91a4-5d9d5ad713c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2017","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:82b2f12a-3eae-4586-9bce-561a61cd12b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2017","original_object":"UniProtKB:P32745"}
{"id":"b54d9714-98c0-48fb-a705-d2f58d2ce3ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1874","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:6814f6e8-13ba-46fc-922c-4b3d3e164ea8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1874","original_object":"UniProtKB:P49683"}
{"id":"eb48cb23-7bdf-4a47-b513-f1d7a32dcabe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:164890","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:f37ec8bb-8ee9-48a2-9969-0786d28e2e55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12424","original_object":"UniProtKB:Q9NYV8"}
{"id":"e0d147a8-4a4c-424d-8681-5dd5df9596b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:223312a8-134d-4cf7-aae6-a3b61cada37f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:P50391"}
{"id":"fa009f27-fc5b-4a12-bd93-a1ac7edbacbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BW5QA5GEW7","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:6c7d5e6e-6fe1-4c33-8b86-ab82b2cd195c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13063","original_object":"UniProtKB:Q92793"}
{"id":"6e2eaf30-a241-470f-b81e-d507953ff3b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44185","predicate":"biolink:affects","object":"NCBIGene:3146","sources":[{"id":"urn:uuid:9e492120-eb42-4eb0-8063-24ce7d91aa62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4815","original_object":"UniProtKB:P09429"}
{"id":"3e6d538b-db20-40c2-a9c3-6f1a1de1e017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813902","predicate":"biolink:affects","object":"NCBIGene:54112","sources":[{"id":"urn:uuid:d6852e1c-4c48-474f-b688-36ab8f6de72f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10031","original_object":"UniProtKB:Q9GZN0"}
{"id":"7e7c07d4-03ea-4da8-b387-0ea7b12802fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:48e9cf9f-187a-4a4d-988e-d6d33f8bf6ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q8NER1"}
{"id":"6b132282-be62-4f69-a745-7949ab2effcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118160666","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:d4f11bd8-2b94-40ad-b5dc-e35b7109209f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10693","original_object":"UniProtKB:P36544"}
{"id":"af5db966-3cc7-45b4-9024-c53690ba70c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:72d75da3-273a-4b7a-9a98-0a1987e94ef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:P24941"}
{"id":"41742421-4ae3-48b7-af01-615a99204c03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90528","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:204e5193-bc75-4c7f-ab73-fb6227fa0c0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5719","original_object":"UniProtKB:Q15759"}
{"id":"1a59ca4e-dbd2-48e2-b99c-53cf61997ac5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93768","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:6a924162-54f1-461b-b766-9a08cc7571f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5683","original_object":"UniProtKB:Q15418"}
{"id":"12213413-7ea0-4b77-b57b-54757e8bcce9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9445","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:e1a46c28-eb41-4d0d-96b5-50160ee20d93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7302","original_object":"UniProtKB:P35368"}
{"id":"248d7ef4-9c48-4f32-96f3-21196f13ec62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:5319","sources":[{"id":"urn:uuid:74e88e34-e91f-41af-8a02-ee983b75a8b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:P04054"}
{"id":"ee3d355f-83bb-4a3d-acf8-4a1bc763281a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44449334","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:99486ea5-5c44-4001-98ea-637c26f733ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8080","original_object":"UniProtKB:Q9NWZ3"}
{"id":"3dc1fafc-44bd-4cb6-aa13-0bc8db380497","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10001434","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:1c32e787-77cb-46a3-8538-3bc315fc523e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4326","original_object":"UniProtKB:P31644"}
{"id":"23819a45-1ca5-4d57-88e0-b0dafcff6e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:23235","sources":[{"id":"urn:uuid:22fd6842-d8b1-49b1-8c26-af2480297d9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q9H0K1"}
{"id":"72c6492b-b406-4802-b14d-47c0a4ee7478","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755071","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:7145e732-c484-4d2a-ad54-54f3fa4fdb73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4039","original_object":"UniProtKB:P35408"}
{"id":"b7249980-113b-4485-a506-022cc18fbdc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8356","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:4a5db0ea-a5d7-4e31-a7af-81c268513937","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:953","original_object":"UniProtKB:P14416"}
{"id":"09e557a5-87ca-40fa-a69c-3e9cc4f8deeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46245518","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:483848df-1f40-4390-b9eb-36dc43599dc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9191","original_object":"UniProtKB:P41145"}
{"id":"f7b8201c-e1e6-4f72-9829-7a6e7f5e2c59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7640","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:ecb3f9af-8c8d-4b6a-b5ad-a99493e51d55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2404","original_object":"UniProtKB:P48542"}
{"id":"db246ddf-3a24-42fc-be78-cb182e23feb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:44be9618-a3ac-42d7-9539-e51ca11debce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:O75311"}
{"id":"5ee68b47-6591-4dfd-97ef-ae9f9072e7be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4314","sources":[{"id":"urn:uuid:5b0b7a20-5aba-46ba-a99b-e72163eaf963","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P08254"}
{"id":"d0cb3da4-ca95-46a6-8438-d9f483fdbe2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92215","predicate":"biolink:affects","object":"NCBIGene:367315","sources":[{"id":"urn:uuid:f5f9deef-c783-4697-aa9a-976e8915bb1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2919","original_object":"UniProtKB:Q33BM1"}
{"id":"e8588b52-d4ed-4dbc-b1dd-3377d25beeda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67171","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:2412fa77-b9f0-4b0f-91a3-a9a8c19dbaa2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9885","original_object":"UniProtKB:Q13464"}
{"id":"20283e81-ff0a-4d2e-9a77-b0fb3bb9abbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90403462","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:3e500ea0-acd5-49ab-bff5-896116298d65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10421","original_object":"UniProtKB:Q9UL62"}
{"id":"48113338-6b25-4028-ab24-24c884821733","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9649","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:ed1b640e-7d0d-44c3-883b-7bc17608d2e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6453","original_object":"UniProtKB:P12821"}
{"id":"4d443c77-be42-485f-aec3-741e79392a6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91399","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:cac6608f-39af-4514-b650-d2f24516025c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5670","original_object":"UniProtKB:P24941"}
{"id":"fd8570b0-efcd-41b7-bd33-0b0857fb5c47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183836","predicate":"biolink:affects","object":"NCBIGene:57260","sources":[{"id":"urn:uuid:e10027e2-caa7-40f4-81d3-4ff0e50eff1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6161","original_object":"UniProtKB:Q9JJL9"}
{"id":"6da80c4a-a8eb-43eb-b328-c07902f56971","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:1187","sources":[{"id":"urn:uuid:10caa155-c878-4f29-a882-459514872ad2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:P51800"}
{"id":"38f9afbc-80f1-409e-8da6-d74ebb8cf7a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31801","predicate":"biolink:affects","object":"NCBIGene:24873","sources":[{"id":"urn:uuid:8bbb36ed-b2a6-46f7-bfb0-cc91877d1289","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2784","original_object":"UniProtKB:P13053"}
{"id":"726f32a6-c5cc-453b-8851-8f45c546ee4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438358","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:7bf0490e-8643-4502-8fa0-9ba5a9cdc877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6157","original_object":"UniProtKB:Q15722"}
{"id":"371ab43a-15c8-4ac9-8485-26ce1ac96f0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:298521","sources":[{"id":"urn:uuid:4b6b613d-52ba-461a-ad1b-a5cf15a0cb79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4231","original_object":"UniProtKB:P42264"}
{"id":"a2cd0ead-5bed-47d5-9c35-4b53c89d5bd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:770","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:1f06919c-b2d5-42e1-9626-f5105d547579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:770","original_object":"UniProtKB:P41597"}
{"id":"1e095bc8-2e81-4a34-9985-78ef2e8b8fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7949","predicate":"biolink:affects","object":"NCBIGene:9263","sources":[{"id":"urn:uuid:2d208873-79df-43b7-b442-c55c92392e4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7949","original_object":"UniProtKB:Q9UEE5"}
{"id":"7421c6db-8c30-43aa-83f3-7885c7e573fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11658073","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:31b77acc-4628-449a-81ac-0045616e2ec5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3208","original_object":"UniProtKB:Q62967"}
{"id":"e7ce7502-455b-4413-aa63-19094c356213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15335","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:83e64130-b323-474b-a5fd-68cb09a0f642","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13776","original_object":"UniProtKB:Q16678"}
{"id":"d45d4757-c845-4142-a3c1-aeccbff0592b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:db46cf0c-1089-4a0d-b50d-86afdc0a461a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:Q14643"}
{"id":"67d21b5c-f0c4-4dff-b5e5-c2131c56b351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3175","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:a999b9ae-7520-4b17-abb5-a9637a580718","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:520","original_object":"UniProtKB:P18825"}
{"id":"4587c76a-5b65-48bf-bbca-fba1364531dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54613583","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:ecbaf536-4d67-49e8-b3b7-4483f55025e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8156","original_object":"UniProtKB:Q86V86"}
{"id":"59e43ebe-ce8a-47e6-be98-b96f96c318f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:00953a3e-a921-4cb7-a3f2-d76042a5b4bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:O94759"}
{"id":"89dae3f5-214c-4956-8aec-b46e2525785b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9588","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:e5e2b4aa-31d2-4556-a7fd-d2590a339711","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9588","original_object":"UniProtKB:P43220"}
{"id":"982c75a1-a958-4627-86ed-45c24b160efd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44309732","predicate":"biolink:affects","object":"NCBIGene:23549","sources":[{"id":"urn:uuid:9afac3d1-c961-4822-b791-2ed4fce17f68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8677","original_object":"UniProtKB:Q9ULA0"}
{"id":"2399925c-fb51-42ac-a1d5-e0f811054557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911338","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:94f6e1a2-df07-4584-be11-138afee7c016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10437","original_object":"UniProtKB:Q9Y243"}
{"id":"f7db53a3-04e0-4a94-b345-bb8a31e350e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:b70fe971-3d3b-4411-9df4-4b9b518eb91d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2645","original_object":"UniProtKB:P10826"}
{"id":"74633676-61e5-4e5c-ba69-f0d1aa3a98d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:2901","sources":[{"id":"urn:uuid:4415a37b-753c-4428-9f2a-3ff07cb94528","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4231","original_object":"UniProtKB:Q16478"}
{"id":"8b4f10c5-5785-40b8-9c26-1876a1451961","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:20182","sources":[{"id":"urn:uuid:fb606e44-8fe4-449a-ae3b-8a632fb1f1e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5383","original_object":"UniProtKB:P28704"}
{"id":"e12a8c03-bc1c-4df8-af48-82ea494e7ea1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2189","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:99fcd8b9-fdce-4f4e-8801-83655629b50f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2189","original_object":"UniProtKB:P30560"}
{"id":"7498ea25-d982-4616-9a73-12536da9850d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817410","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:12e7f612-45b6-4b16-8bf5-7f38b302076e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1463","original_object":"UniProtKB:O43193"}
{"id":"d1872af6-398e-467f-b558-f1f89c1025ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145365","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:c7c39062-0d1f-402e-9738-eabc8d0c4995","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7882","original_object":"UniProtKB:P16234"}
{"id":"4633ca5c-9646-4296-bbb0-a0e8137a6ba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6979053","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:f536ae15-a5b5-40a2-9593-b9174ed25115","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:288","original_object":"UniProtKB:P20309"}
{"id":"66240db0-e452-43be-8327-a1770cc45505","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9166","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:989ac603-aebb-4d3c-abfb-11696fc976ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9166","original_object":"UniProtKB:Q6W5P4"}
{"id":"8179954b-7862-4f4b-b701-d6e76098012d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:187817","predicate":"biolink:affects","object":"NCBIGene:6095","sources":[{"id":"urn:uuid:7feaf5f6-5add-42bf-a2d3-65131983245c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10143","original_object":"UniProtKB:P35398"}
{"id":"3105d8d7-455a-44bb-9fab-81163c7bdd7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93768","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:feb19749-6d95-4e5d-af85-d15b640e5b39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5683","original_object":"UniProtKB:P08069"}
{"id":"57d5dde6-144a-47c1-a61f-aea4e16193fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110176","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:9512ac3b-0323-45c0-87c6-31bcef100e47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3264","original_object":"UniProtKB:P08912"}
{"id":"dcf97493-6fd3-41e9-8218-25209103c332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QQA9MLH692","predicate":"biolink:affects","object":"NCBIGene:930","sources":[{"id":"urn:uuid:41b6a0ec-2e37-493e-8465-8b8a69fc436e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11131","original_object":"UniProtKB:P15391"}
{"id":"38702e1a-d51b-4bb4-a93b-404be4b90809","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:9c687c35-6581-493e-8862-464f34015e56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2342","original_object":"UniProtKB:P15389"}
{"id":"49a6f916-5057-4e5b-b25f-f98dd7c3b32f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109545","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:b14be219-29eb-4e5a-905e-11d4900e5abe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1346","original_object":"UniProtKB:P49286"}
{"id":"95162b49-7d54-48dc-8cc5-c96003ec9e6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827384","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:33b2f4d1-aebc-4b17-bac7-59dd930a3a0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8646","original_object":"UniProtKB:P53350"}
{"id":"65b033a0-c003-4eb8-83c4-5b681db74be7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146219790","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:12c374f2-7f19-4164-aa5a-06960f6c2158","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13485","original_object":"UniProtKB:P11802"}
{"id":"8e89e75b-e711-4f41-9d7c-01aa3b2aabd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:754c2aee-9dae-4ad1-9eb3-15b5c9b30836","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2330","original_object":"UniProtKB:O75469"}
{"id":"5ec68b3a-54f7-4e76-be04-c9325d5e3344","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S4N4U44G8","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:f7209ed4-e02d-4053-8a99-39460790d0a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6215","original_object":"UniProtKB:Q13255"}
{"id":"e0dd1ed8-f5cb-4656-8727-c16d023551a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:57165","sources":[{"id":"urn:uuid:75160e2f-c81d-43ea-9f1d-8c0b55110125","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q5T442"}
{"id":"9a3c822f-1cbf-4fd2-9300-1732a6b61dc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:77461013","predicate":"biolink:affects","object":"NCBIGene:23643","sources":[{"id":"urn:uuid:a8375502-9faa-4e5b-be2e-878566daac9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9137","original_object":"UniProtKB:Q9Y6Y9"}
{"id":"be038188-a23a-433d-b516-3328efeffce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7872","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:f33c9e1f-ee5b-4568-ba5f-122f1c1c9eb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2174","original_object":"UniProtKB:P37288"}
{"id":"cde3e843-caf8-40ee-81a2-d8973880ef04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422745","predicate":"biolink:affects","object":"NCBIGene:4139","sources":[{"id":"urn:uuid:780e5f99-bb9e-46bd-bf35-1ba0bd99ddde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12936","original_object":"UniProtKB:Q9P0L2"}
{"id":"d7be8145-6ff7-44b7-9082-6d105f180805","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44577753","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:c5865cd0-57b5-40d2-9db0-238d3b7e772c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8121","original_object":"UniProtKB:P36894"}
{"id":"9813b122-a5de-4293-86f5-2744d4c4955a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:53c43a97-cdd8-4e2c-8712-6837abb7952d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:O43318"}
{"id":"a1c47fbe-2746-4dea-a476-3b32e1758bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6076","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:a9f30f72-40b5-40c2-91fa-8d7250fa5e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6076","original_object":"UniProtKB:O60755"}
{"id":"8b35c9fc-1209-449b-a80b-e9afa9dc38b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46203250","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:03c2a4c7-01c8-4ed3-8bc0-b01f86ebe3c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8690","original_object":"UniProtKB:P55055"}
{"id":"2e3d4589-6a7c-44c5-b63c-8536688d1068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:709e19ca-7f59-4d30-94a0-64aae59850c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:O88704"}
{"id":"42baf114-a444-4407-b341-bf77450df7c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:fcc18d58-8527-4f0b-8577-54cb710a8914","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:P48736"}
{"id":"fc4b6d24-85c8-430f-b806-3507f0677e45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177844","predicate":"biolink:affects","object":"NCBIGene:24473","sources":[{"id":"urn:uuid:52fb2b80-61c2-442b-9c62-b902654496a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10446","original_object":"UniProtKB:P19327"}
{"id":"540a1a22-8d21-4209-873f-5b2ff3954e4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755226","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:c51720db-7318-4eea-be20-993e1b43bed8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6579","original_object":"UniProtKB:Q9UBY5"}
{"id":"3b59b646-c1c8-40bc-8b61-946fac5942ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233305","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:d6b48250-82bc-4386-ba4b-963620991115","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9368","original_object":"UniProtKB:Q9P1W9"}
{"id":"c0bb6ceb-9185-4e4d-96e3-1d1f55695f56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77780","predicate":"biolink:affects","object":"NCBIGene:1559","sources":[{"id":"urn:uuid:7b106b71-c142-4f71-8b12-b8d5ec287423","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11352","original_object":"UniProtKB:P11712"}
{"id":"86809fa5-05a8-49b9-bcc4-d2dcae59d41a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125555","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:fe03042b-0699-4491-9651-5aeda816d542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8980","original_object":"UniProtKB:O60341"}
{"id":"d58aed0f-c923-4e15-a7dd-f5f9e09a7357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49831044","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:d70edd50-5e0a-47bc-a8e9-aea411fedbc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7700","original_object":"UniProtKB:Q16620"}
{"id":"183ada1d-d21f-488e-b057-993895896ce8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95060","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:14154097-17ca-42f6-a7fa-cc6939042da4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7379","original_object":"UniProtKB:P06493"}
{"id":"b583aaab-d09b-460b-8076-b2724709e6a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:23a3b7e2-0ec8-4433-a977-63a25c60afa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P28566"}
{"id":"83d9bf57-83a6-46e6-b456-f7fe0fe84870","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6104","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:1a98891e-ae6b-4b3f-a208-9317eb3cc386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6104","original_object":"UniProtKB:P47211"}
{"id":"fd3bbea8-d47a-4eaf-ba38-793867737b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135274950","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:9f635fe8-6c5c-4d73-a9e2-aad8ded5efe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12722","original_object":"UniProtKB:P31749"}
{"id":"e38197c4-e93e-433a-a070-6da3eb9f2a2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233896","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:c38c7ea3-c735-432a-aeca-810eeb5e41a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2957","original_object":"UniProtKB:P51639"}
{"id":"ec64b942-f04b-44d5-9e03-377a536fb324","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:236501","predicate":"biolink:affects","object":"NCBIGene:84875","sources":[{"id":"urn:uuid:9c4bd27d-aa7e-402b-9b4d-3902bcc142eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13119","original_object":"UniProtKB:Q53GL7"}
{"id":"de97aae1-3350-4ae8-add8-173cc1b9b6fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:40","sources":[{"id":"urn:uuid:fd724d6d-1a9e-4286-b91d-695806e7cb54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q16515"}
{"id":"92b85544-cf74-4392-a9f8-fa0d241958bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73297","predicate":"biolink:affects","object":"NCBIGene:3763","sources":[{"id":"urn:uuid:05681b9d-b15b-4aef-ba79-0cdae1cc5730","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:943","original_object":"UniProtKB:P48051"}
{"id":"cd10d457-0b99-415f-aa19-df340f848a30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O812716S9E","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:be8423ac-5de8-472a-bd9b-35fabdf9a179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9306","original_object":"UniProtKB:P56718"}
{"id":"9c82ecf6-2e9b-43a4-8ed6-e98ff07d202c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494481","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:5fc94119-ff6c-4190-bada-da81a05e20bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13044","original_object":"UniProtKB:Q96P20"}
{"id":"20c94fbc-2573-4e31-ba01-68baba5912e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10224714","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:a05d4fa4-19e7-4e99-99f4-45b9adf0d51c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11065","original_object":"UniProtKB:Q00535"}
{"id":"56170482-d4c7-46d6-87a3-470aa528bf5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4293970","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:dc872a5b-f953-48eb-a14e-37d960b40e1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10151","original_object":"UniProtKB:P42336"}
{"id":"148a779d-7b1e-4b00-bd6b-a1f7cbedd94b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X741EI11EL","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:b1b5de45-ef5f-447f-b6b1-1e0bbc57acc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1648","original_object":"UniProtKB:P34975"}
{"id":"4b84627e-11ca-428a-9772-18dbd0447c2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3Z11398FNQ","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:dd1e823b-5110-4ac6-8187-2b35b585bd66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12768","original_object":"UniProtKB:P10828"}
{"id":"57502060-a918-4a15-8e03-0c0bcdfc7c90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4164","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:5918e0b3-974b-4621-a36b-6ff998986062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4164","original_object":"UniProtKB:O75311"}
{"id":"b62792cd-3130-4395-abc2-b15585e98cb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1807","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:f19a1eae-87e3-4389-9a54-038145a29dd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1807","original_object":"UniProtKB:Q03431"}
{"id":"9602f678-9f9e-4597-927b-35c7aea851fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0BQ383G656","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:75745d9f-a3d4-481c-978a-4e13b1a61409","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11860","original_object":"UniProtKB:Q9GZU1"}
{"id":"b171146c-fb0a-485d-8a07-53bb3a901d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10416728","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:0e17bf92-4441-4c03-b319-0b5eacb764e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6910","original_object":"UniProtKB:P30556"}
{"id":"26f92748-69e6-431a-bfe1-60d324bcf74a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:be1146ee-bc1e-471e-a9e5-845ebfc197d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P18825"}
{"id":"2a7e5d4f-f4d4-4a3e-a287-464aa7b6b538","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:176096","predicate":"biolink:affects","object":"NCBIGene:5091","sources":[{"id":"urn:uuid:532a1184-d1d3-4645-8a4d-85c7637fce84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13780","original_object":"UniProtKB:P11498"}
{"id":"092b920d-e5dc-4be6-a1e5-f02e38a021a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:03KSI6WLXH","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:d7f50068-0618-4130-b82c-f2edffba6275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9150","original_object":"UniProtKB:P41143"}
{"id":"b95000b8-ad24-45d1-8078-c3ca2e62c28c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66833213","predicate":"biolink:affects","object":"NCBIGene:383","sources":[{"id":"urn:uuid:b92bfea4-e194-4fa6-991a-0c136952d3fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9017","original_object":"UniProtKB:P05089"}
{"id":"96b56390-75ef-43bd-9b86-c21bcc9c5e01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177416","predicate":"biolink:affects","object":"NCBIGene:58959","sources":[{"id":"urn:uuid:0c2b18f9-9957-47af-9fd4-30171e58a514","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10379","original_object":"UniProtKB:P35353"}
{"id":"097e3693-2e99-4fcc-a64a-67f3c3f57983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1527","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:d8762251-9153-462e-bb8f-377f6b6019ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1527","original_object":"UniProtKB:Q15761"}
{"id":"8c9288e8-cbdf-426b-beee-8d28f5761b1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:eae9cb52-a334-4264-8188-625bd73fbf1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:P31422"}
{"id":"29cbd5fd-6460-4777-ad81-ab07bd2b607c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134689","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:38a5c6d6-3a87-414b-b5f2-b5dd29681c47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7736","original_object":"UniProtKB:P09874"}
{"id":"d82b907d-41e6-4760-865b-938c08e2146e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:eec77bdf-54c1-449b-85d8-ec4405c17ca1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:Q62053"}
{"id":"61f2279a-693a-4a20-8cb8-d82d32a40de4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:c315a0de-3732-40cc-964d-929c61e2de6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P11362"}
{"id":"a08acac4-7b76-40e7-87cf-b79a99c0989d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699465","predicate":"biolink:affects","object":"NCBIGene:319239","sources":[{"id":"urn:uuid:4751d378-e6f6-4597-aa9c-95a9b3c40359","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11226","original_object":"UniProtKB:Q8BZP8"}
{"id":"7410810b-b35b-4ad7-ac00-ddbf655c95a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139031070","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:d969331f-1dec-4f20-a885-00dc9436b145","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6911","original_object":"UniProtKB:P30556"}
{"id":"c9706083-3e35-4c10-b88b-8ba207210684","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:537603be-3286-4638-898a-ddc72a7a8947","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P34995"}
{"id":"64ef801e-b118-45a2-bfd9-a447e2d3b650","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32176","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:32bf6c3b-5cc7-4a8a-a9f2-8d094efb92ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2780","original_object":"UniProtKB:P11473"}
{"id":"4769dfe9-aa57-47ca-ab5a-6ac9130739cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9CAS0V66OI","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:1ac70a24-3c44-4890-ac59-d40a99c3be6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5018","original_object":"UniProtKB:Q9NYK1"}
{"id":"f37ae8ec-1afb-4860-a9f8-4f9d2153c3e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19077552","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:916c4e9f-58b4-4d17-9a15-cfb46ff6d483","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3095","original_object":"UniProtKB:Q02769"}
{"id":"125328eb-eb65-4f80-8d9c-391b7e683a7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2366","predicate":"biolink:affects","object":"NCBIGene:259293","sources":[{"id":"urn:uuid:788c166f-0e9f-47a7-9098-0483f319e068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12458","original_object":"UniProtKB:P59541"}
{"id":"b9cfb802-0847-449d-8362-79f94376e49d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5282428","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:aeada22b-bf66-4316-a9d9-07adbd5fb975","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1967","original_object":"UniProtKB:P43115"}
{"id":"b3834c5d-2794-4b00-bbe6-755f68324f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14533720","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:35740bad-d600-4339-ac85-9b1f72694e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6","original_object":"UniProtKB:P28221"}
{"id":"1a49c346-a1f7-45cf-9969-2448cf225a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28121","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:9c1b93f3-b32d-49ee-a4f9-558459074783","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9352","original_object":"UniProtKB:Q13627"}
{"id":"45a63914-3cda-4780-9688-d3ac8bfbf9b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9915756","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:8c47e7e0-3b9d-4fd3-bb0a-1405adcbf8f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:904","original_object":"UniProtKB:P30551"}
{"id":"0908d339-bb6f-43f3-bd8a-76c61c8a93c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230107","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:9200ede6-1380-4c85-849a-9c3f4c424586","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1633","original_object":"UniProtKB:P35372"}
{"id":"b344ecbe-0712-401c-94b3-940ee22a4d53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10048862","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:2e118127-dc7a-43a2-882a-f76a9ac2e865","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9415","original_object":"UniProtKB:O43613"}
{"id":"845b8db7-cda7-48c7-875c-04a197809ebf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93986","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:2ba6ae20-f4b7-458a-84be-edf862fc68f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7014","original_object":"UniProtKB:Q96KQ7"}
{"id":"5f14e53e-06b3-4a39-af0b-0eb7a846c1c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277875","predicate":"biolink:affects","object":"NCBIGene:2289","sources":[{"id":"urn:uuid:4d9c3705-2f29-43c6-a3d3-1fee3c049832","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11481","original_object":"UniProtKB:Q13451"}
{"id":"50cd2838-f603-45ca-8feb-57cf7e924c61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91359","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:0158e4a3-c282-4559-ae2c-2fd11d463561","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8059","original_object":"UniProtKB:O00329"}
{"id":"56b4176f-eb0a-4772-a8e2-ca765c243cd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:309713XSKW","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:b06e1c22-24cc-450d-a73d-8958383c26d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1244","original_object":"UniProtKB:Q9Y5N1"}
{"id":"41e5d2b3-b4d5-43e9-96ae-62a39b0ebafa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5071702","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:9a1c1a46-5d73-46ad-ad0c-8d452d2ecce5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:780","original_object":"UniProtKB:P41597"}
{"id":"bf8ae6f7-cb9b-459f-b7d6-8187f71fc795","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6741","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:93da12d6-2758-42cd-aa1d-f0198e348805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7220","original_object":"UniProtKB:P23219"}
{"id":"3d2e74f6-7b1f-42c4-bd05-f6390c2a410e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311433","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:aac22600-e96f-44c9-8392-1f199435b3e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4314","original_object":"UniProtKB:Q5XXA6"}
{"id":"87c30cd3-5eb7-4ee3-a865-67321bfda3c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:c3ce9952-7c51-48b2-94dc-6597d1f394ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:P56479"}
{"id":"b3df06f0-d829-4fb7-8da7-a8f93ccb20be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JH0PQ88XA2","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:b2fb21c0-a6db-4878-9285-0af327437d16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9511","original_object":"UniProtKB:P25090"}
{"id":"070b8588-0122-4add-90ed-412fffcd0c4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122227","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:7d14be84-ee99-4a71-909a-f003dd55c941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:644","original_object":"UniProtKB:P97583"}
{"id":"e99e6288-0432-4572-bcc1-b5ced30a471f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92310","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:0a23241a-6ae4-4c10-b61b-baba74b0fcc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7625","original_object":"UniProtKB:P35462"}
{"id":"ace27a59-00a5-4111-b09a-7d8ea8a93ff5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65349","predicate":"biolink:affects","object":"UniProtKB:P10608","sources":[{"id":"urn:uuid:4318b5f5-0710-4ccf-a3e1-46681b7f2ef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7445","original_object":"UniProtKB:P10608"}
{"id":"85f68a55-3cba-44fb-a1cc-4a0f94315748","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163321087","predicate":"biolink:affects","object":"NCBIGene:57787","sources":[{"id":"urn:uuid:470ea511-03fd-4853-bbb1-f98d046ab889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12937","original_object":"UniProtKB:Q96L34"}
{"id":"0e4600cd-5d5d-4175-8b52-2efd03a2c9a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232556","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:e45cfbc4-1823-4ef0-8c05-0cbecf32b170","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9039","original_object":"UniProtKB:P21802"}
{"id":"1ec1d4a9-dd34-48dd-8a60-99d022923831","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10593671","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:6df00204-97a7-451e-b4bb-cf1eb5a17d8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:397","original_object":"UniProtKB:P25099"}
{"id":"2b5ef56f-7ca0-4c11-aff7-6383a4d25f9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11503055","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:e48d8050-fa5a-452f-b0b4-3def0308bf15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9694","original_object":"UniProtKB:Q14832"}
{"id":"f22b70db-23a3-424d-9938-05bff88fd036","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311225","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:2facd5fd-c878-4f04-9e41-2f50bb133b82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1918","original_object":"UniProtKB:P43115"}
{"id":"290a689e-86fb-41ec-9539-abfeedaf168f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156855755","predicate":"biolink:affects","object":"NCBIGene:7003","sources":[{"id":"urn:uuid:2eda68ec-a240-475d-b60f-9b91ffbf275d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13367","original_object":"UniProtKB:P28347"}
{"id":"85532720-98e6-43b8-a6cf-0ee7b924e7f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2190","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:8be9377e-b934-41cf-8d5c-169ac2108524","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2190","original_object":"UniProtKB:P47901"}
{"id":"bba94e58-4cad-4511-866d-7fc21256d9e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8207","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:0d72d53c-4722-4557-9bc4-0bae6568ef7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:305","original_object":"UniProtKB:P08482"}
{"id":"7d30e321-1e74-4e59-ad1c-dbb75b1de0ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11222922","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:0fa4ee81-3afc-4d2f-9f56-9ed1d7cd959e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2333","original_object":"UniProtKB:O15554"}
{"id":"47cfb70f-9746-4aac-862c-2100a1c7f40b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138885","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:5655d495-f3ea-4f95-be23-4f4a78a3b549","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6505","original_object":"UniProtKB:P45452"}
{"id":"cc42095c-e6eb-4a58-90cc-4b4a257e6029","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:174251","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:a955f9e8-9b02-4c3b-ac00-4e0607ecf43d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13466","original_object":"UniProtKB:Q08499"}
{"id":"be0aee83-f294-4139-ba04-7aa8bd216db1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:4486","sources":[{"id":"urn:uuid:dcf31921-1138-476d-b9e8-cb09582b0370","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:Q04912"}
{"id":"69ed003e-22d7-4030-a88c-5915da3c91ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6102","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:932504f7-4a8b-425b-b942-dd9b02043d83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:650","original_object":"UniProtKB:P97583"}
{"id":"0113fb88-3bbe-490a-9f31-6b6cebd2ddd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2528","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:92876f9f-2c6d-4a7c-9bff-80da097ee6b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2528","original_object":"UniProtKB:P54282"}
{"id":"d80c5909-aeef-4fd6-8b9c-30ae571e1aae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:2265ba2c-c2cf-4313-8f00-c06ae8c752b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P23944"}
{"id":"60fa2a50-2366-450c-a170-61a80feeef22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:50aae5b4-1e66-4cfe-a760-ce26e4b33296","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:P80192"}
{"id":"9907ec4f-1f3a-4844-89be-d552060b28a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1040","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:cf942ba1-a021-4589-8344-dfea5d22e8e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1040","original_object":"UniProtKB:P25089"}
{"id":"e61a0276-4700-4a01-a8d8-42736ca8a667","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435286","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:c75ccf2c-36ac-49aa-8b53-97c901dbfc84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3353","original_object":"UniProtKB:Q9NS75"}
{"id":"a2e1a4cb-22de-451f-9411-6e3cbcaa238e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:26cb5aa2-ff62-4080-9da7-927c7c0d9fa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P35462"}
{"id":"c7f8916a-8f19-4986-97a3-e81c5ac81066","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321160","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:23025997-fe14-480e-9a17-6599a84536aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10157","original_object":"UniProtKB:P52333"}
{"id":"d6884764-4371-4d3f-b0e7-796644aea342","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197437","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:e596077e-c527-4f74-b2fa-b36bd9bb345f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7008","original_object":"UniProtKB:O15379"}
{"id":"df9479f9-e7a6-42a0-8771-48025d2f4d73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2027","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:a5de4911-1a65-4a33-9238-5742f84d89c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2027","original_object":"UniProtKB:P30874"}
{"id":"f2ebb271-bc55-47c0-a739-499ea65ab89e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7DR7JMB8BH","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:b63d49c9-5503-4191-a7b2-0091a5bf720a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8959","original_object":"UniProtKB:P08581"}
{"id":"5454fdbb-05c9-4563-bee6-4388dcf7b86d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93432","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:201ba2bb-8c2b-4535-9343-fb754dee766d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8584","original_object":"UniProtKB:P11229"}
{"id":"e97db914-8382-4768-8255-a108969fb0d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604914","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:d8eda96b-0be2-4b66-9635-f83145dc941c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2289","original_object":"UniProtKB:P46098"}
{"id":"e6709d05-5f16-4730-9d23-8d9d58dd12c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184662","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:7c125218-77e4-403f-a274-f5497f732d27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:806","original_object":"UniProtKB:P51681"}
{"id":"06f517af-4983-4115-ab27-3d24269c8c41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:506ca823-4989-410f-859d-6c27a837b953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P30939"}
{"id":"56f4c035-2408-45fb-ace3-645a8b012ce9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:e87dd6d8-34a4-4b53-a1c9-269771f4abd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P35916"}
{"id":"65bd976e-143a-4b33-b134-3e1cc8a251f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54760053","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:e34e486a-5158-42a9-b6ac-45e4fc7b8e6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8095","original_object":"UniProtKB:P10721"}
{"id":"c92d9148-3f45-4a6a-b9da-97aa989f5515","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133021","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:4bddb443-25dd-4194-9cd1-da4820375f81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8318","original_object":"UniProtKB:P10415"}
{"id":"4d648762-f39f-4a91-8da9-53d13558df4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:6a79bd00-a9f4-49c6-a8ea-9c258f064604","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"72187ffe-c5c3-4902-bbdc-9614ca41e8df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JAC34RRR7S","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:4edd4ff3-eba5-4984-a677-a66821d5a096","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11716","original_object":"UniProtKB:O60674"}
{"id":"d66e5515-1dc3-49e4-8454-c269d0c7817c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:20c2c00e-922c-4f43-bf28-f48dd256ee0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5387","original_object":"UniProtKB:P07550"}
{"id":"0a635385-248e-4364-836f-0decf4ecd77a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2329","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:29450b1b-d9f0-4583-8a46-74aa9b3034d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2329","original_object":"UniProtKB:O15554"}
{"id":"9b527b8e-4bd6-4502-adbf-ce2c3f3deb30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4010","predicate":"biolink:affects","object":"NCBIGene:8973","sources":[{"id":"urn:uuid:65074a66-97db-41d8-b910-d6447ee4755b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4010","original_object":"UniProtKB:Q15825"}
{"id":"524705de-80ac-451f-ab30-7d42a2705a65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312119","predicate":"biolink:affects","object":"NCBIGene:25245","sources":[{"id":"urn:uuid:55066d1a-2f5c-407d-88a6-2d87fe4f01e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:680","original_object":"UniProtKB:P25023"}
{"id":"76ac52fb-6ee5-4231-826b-a4dfd937dc5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11968293","predicate":"biolink:affects","object":"NCBIGene:24816","sources":[{"id":"urn:uuid:9e9308a5-7dfe-4445-9283-73d78982b664","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3387","original_object":"UniProtKB:P34978"}
{"id":"8b1fb499-c4be-4fac-bc5b-ea5bb1fdc15b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2703","sources":[{"id":"urn:uuid:dd4d9aa7-5404-421e-9afd-1e386045ba39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P48165"}
{"id":"8a4213f3-6051-4e57-b78f-eb15cd11cf7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:82e4e634-ddd8-4155-9685-34d5e4c73c43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P32305"}
{"id":"14dc6597-8e73-4ef8-af3e-32e8bb31b7db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10391971","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:cfa8235c-55f9-4512-a15a-2d616a3c793c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:418","original_object":"UniProtKB:P29274"}
{"id":"ebc5cf43-bb2d-4d5e-a40d-43373694dd2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25149704","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:7c728ca3-4ae1-4943-9a26-0a5b505d8195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1198","original_object":"UniProtKB:P35367"}
{"id":"167ed37b-5afc-4865-81ff-840eee18c287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104162","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:6b14c99c-d3a8-453d-8188-d76b23360221","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10104","original_object":"UniProtKB:P20309"}
{"id":"97979617-c843-4851-8bde-fb6d52bbf86c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39912","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:ddc7d6c2-91c0-4030-b08b-ad4f3ac848f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5783","original_object":"UniProtKB:Q9BXC0"}
{"id":"c52a5817-130b-4a5d-b4d3-c298d8e6a4a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11546664","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:f7cf2bb3-725b-4d33-9eba-9f6af7fc7cf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9865","original_object":"UniProtKB:P27815"}
{"id":"4c986f54-d593-4495-a69d-5170f64c89e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310983","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:fc518186-2b32-4904-a254-178e2f7e484c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1711","original_object":"UniProtKB:Q15077"}
{"id":"591d3ceb-0d38-4e41-8017-de04ede7760b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36795","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:63530894-7f3d-4846-9910-1bb637830701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:202","original_object":"UniProtKB:P23975"}
{"id":"78ecfae2-1331-4d08-a9e2-aba85171791e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13443","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:9e1f1aa3-71db-4f6e-a4cb-b8a7383ab296","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13443","original_object":"UniProtKB:P04626"}
{"id":"b23ba23c-6d46-4717-83d8-21a8dfd3f7b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2219825","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:7b272143-1e64-43e8-9902-24bfefa34ee6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6718","original_object":"UniProtKB:P48449"}
{"id":"3181ad61-7b90-4d66-9df7-87322031c530","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15971","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:4cb75eec-b04e-46b9-b7a7-07ec5eea9a69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3310","original_object":"UniProtKB:P00915"}
{"id":"bdbd4c79-3e8e-469a-b9e7-597d8d5b10bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:cd224464-7f01-47c7-b70a-b5555749567b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P08908"}
{"id":"cb95eb6e-4533-4acc-81cb-d525a64b39d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y66IS3CS0R","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:f806834b-a0be-4c83-b525-b4474b0c5dc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7969","original_object":"UniProtKB:P10721"}
{"id":"3d0aed78-91d0-43b7-969c-aa3ad64c8613","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3769","sources":[{"id":"urn:uuid:fb41d181-426b-4b5a-b711-bc694608329b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:O60928"}
{"id":"912d7c10-8296-40ed-aa8d-edc9ab39d7c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J4DRJ9BFS1","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:5c16efcd-eb82-476a-b31f-c1cbc9bfb8d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6126","original_object":"UniProtKB:O60755"}
{"id":"5c77c593-d8f8-413a-81cd-6c81a68e8fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8211Y53EF","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:c34c39ef-a830-4c7b-b943-5786a19b9d61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9232","original_object":"UniProtKB:P21554"}
{"id":"fa2d93bb-ea87-4ff5-bceb-867cb046b0fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134442338","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:81ea3d22-27b1-4ac2-b29c-22009074c010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13489","original_object":"UniProtKB:P07333"}
{"id":"b0a84256-096e-4688-805b-eef814127ab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3654","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:2aa0a61f-d830-48f9-b424-8b17dc239b2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7147","original_object":"UniProtKB:P22748"}
{"id":"3f86fed5-b656-4ab6-93e5-2bca809f4e1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11310142","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:0cd9879e-007b-48b5-b8c4-e022a937804c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11614","original_object":"UniProtKB:Q14416"}
{"id":"1dc979b4-bb8d-4b30-8d04-bab07aacd33a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92174","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:49ef3b35-9e39-47d3-9e0c-2bdface46d27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:333","original_object":"UniProtKB:P11229"}
{"id":"05183d9b-37b2-478d-b06e-9c89fcde719b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817422","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:41087083-ced4-40a5-a7b6-aed697a074b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1549","original_object":"UniProtKB:Q61041"}
{"id":"dac349ed-9c69-4377-95bd-abbc91781572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5790","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4461f461-e404-4ce3-a875-1fe0db381b4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7082","original_object":"UniProtKB:P35372"}
{"id":"2c8d65b6-4869-4434-81dc-d1c9a2eb9fc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9982767","predicate":"biolink:affects","object":"NCBIGene:1591","sources":[{"id":"urn:uuid:198df5db-5eb8-4cb5-9317-54be0749332f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8819","original_object":"UniProtKB:Q07973"}
{"id":"8c2cc947-2810-434a-a97f-efada76033c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49853637","predicate":"biolink:affects","object":"NCBIGene:8394","sources":[{"id":"urn:uuid:959bb8ea-a3c4-44d7-aeb2-43f1b4bdc202","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8444","original_object":"UniProtKB:Q99755"}
{"id":"1a6aa0d5-05a7-4061-821f-2351f2c169ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3819","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:aaf27ed5-db39-476a-9765-5db9cdf6608e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3819","original_object":"UniProtKB:P41143"}
{"id":"cde58656-e6ae-4eb5-a9cc-fcbf71881128","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132129813","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:a1feb69a-d1bd-4a9f-9b06-7fe2c9afcffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11232","original_object":"UniProtKB:P56373"}
{"id":"9b604c0e-b233-40ff-a592-f5dec6eef475","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:48c2e5e7-9089-473b-b35e-2b8e8fbbf4ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P21917"}
{"id":"3260458c-e9ac-45ca-b816-e0f13d8c1582","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72200024","predicate":"biolink:affects","object":"NCBIGene:81788","sources":[{"id":"urn:uuid:a53ddf25-e925-4943-b52f-37baa2be0702","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8047","original_object":"UniProtKB:Q9H093"}
{"id":"ca1186f6-63ee-4739-93b9-c2ce2a8c5efa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54669868","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:6fab58af-7ea4-487e-a26e-408a5304f0b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7516","original_object":"UniProtKB:P25440"}
{"id":"66003f94-6533-4035-8b3b-2c15df4bf2ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0BQ383G656","predicate":"biolink:affects","object":"NCBIGene:255231","sources":[{"id":"urn:uuid:025ac076-e887-4287-8481-03015a2b8596","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11860","original_object":"UniProtKB:Q8IZK6"}
{"id":"32463416-c07b-4756-9ef6-bfe656340d9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N33070GI64","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:88fc3965-7025-4c8d-bf74-774b80c662cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5618","original_object":"UniProtKB:P29274"}
{"id":"58f085fc-6058-404f-9693-010577599027","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9U3GT3353T","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:b1eb1b2e-2007-4e9b-ad48-256c60baf7f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1624","original_object":"UniProtKB:P35372"}
{"id":"87ff62e4-c4b5-491f-8bdd-c0c5817d7303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:00e768cc-bc1c-4823-a3f2-72b86e851ac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P06241"}
{"id":"23276ec2-6e27-45e8-b2b9-c6e6ccb5c9aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:11c03cdd-e85e-4012-97c5-db99ca8e5006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P30994"}
{"id":"38729ce8-d7b6-41cd-9375-31f59ab1051a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433306","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:8909d9d2-0605-4a62-8dbb-f0e84f77b49c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12804","original_object":"UniProtKB:Q9BY41"}
{"id":"db32d681-89f5-4bfc-9197-fb33d6fa0a9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18437138","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:24b845e6-29dc-41d3-8449-7269d1e062c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10750","original_object":"UniProtKB:P51681"}
{"id":"bbf48af9-696b-4bf9-877e-cf8cbb5a7918","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46911017","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:5bfe1bae-29c0-48ee-9c1d-4e7a17e7dc29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12267","original_object":"UniProtKB:P40763"}
{"id":"1cde4040-5134-4623-9d0a-7e272f1c6b8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:da6733df-762c-4af3-97d4-3225818458f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P30874"}
{"id":"d1109e11-49ba-435a-ab5f-b6e3a5fc3787","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8380","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:c9675f29-15d7-402d-acc6-47eaf009c7c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8380","original_object":"UniProtKB:Q16581"}
{"id":"1cb4ba92-9533-438a-9044-40554f9602c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7H7YQ564XV","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:f6bbb7a6-d1ba-4c8a-ba4b-48eade281a1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13539","original_object":"UniProtKB:P35372"}
{"id":"a4d6c86e-402e-4242-9329-f82c8fb44a84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233415","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:8720e6a2-c0cf-4f48-80ff-f782f474c022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9565","original_object":"UniProtKB:P14902"}
{"id":"0e07161b-3e13-415d-a219-e1af2c0215c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31174","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:76e6937f-761d-43e1-a8ce-9325fc168a5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5429","original_object":"UniProtKB:P13631"}
{"id":"8496c763-85df-4d8a-baa8-45ceac51624c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44123300","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:065e6e4a-c867-453e-94a7-ea55c66fb611","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1714","original_object":"UniProtKB:Q9BPV8"}
{"id":"35f2c04b-3c18-400a-84d1-336dedc120f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11914","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:b8d40814-fb8b-4408-99b9-52341834a1d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11914","original_object":"UniProtKB:Q8WXD0"}
{"id":"b1d91a54-813a-4324-a67a-ef7ef64ade32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18344","predicate":"biolink:affects","object":"NCBIGene:64095","sources":[{"id":"urn:uuid:ca93d9e5-635e-4c21-ba59-8ca1bc90506d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2918","original_object":"UniProtKB:Q9ES90"}
{"id":"72b78bf9-0c20-4156-bb2e-7d51f71753cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1160","predicate":"biolink:affects","object":"NCBIGene:3973","sources":[{"id":"urn:uuid:e3853a9d-d1d1-411f-a3c8-d97a1969bfd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1160","original_object":"UniProtKB:P22888"}
{"id":"d9f851ba-ed7c-4158-995e-e2fbb582362e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78373","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:eacc2ace-4281-44ca-b499-2d3e397be381","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5953","original_object":"UniProtKB:Q99572"}
{"id":"73dd0532-a602-43c3-bfb9-b054e7628f5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135939","predicate":"biolink:affects","object":"NCBIGene:29571","sources":[{"id":"urn:uuid:ae803343-f83e-4c2e-8b8d-a7ebae78f49b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7472","original_object":"UniProtKB:Q62968"}
{"id":"761c4f5e-ae44-43f4-aec3-7c5c77239d98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51544","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:078645d0-60bd-462c-a909-fd3c69937c6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1963","original_object":"UniProtKB:P43119"}
{"id":"dc08c56e-cc5e-485a-a668-341da00950b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92941","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:824e7d03-6914-4b2a-be88-66fc112762f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1704","original_object":"UniProtKB:O43614"}
{"id":"37ac3c5a-1612-4396-bcbf-f46903584067","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132290","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:0a3771dd-e6b7-48a2-9305-c8c806ebff75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2548","original_object":"UniProtKB:P63142"}
{"id":"901bb731-6d02-4a04-bd77-821d9d05a43c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189868","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:a8a614f7-2f68-4d39-baf8-379924a1f59b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1614","original_object":"UniProtKB:P33535"}
{"id":"65792429-3365-4915-91dd-0e806c6bdb55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155908701","predicate":"biolink:affects","object":"NCBIGene:8573","sources":[{"id":"urn:uuid:b84b296c-8e57-47ec-aab2-5c647d5bb209","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12810","original_object":"UniProtKB:O14936"}
{"id":"d4a96e40-c352-42c8-9e08-6a22839cdbf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311079","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:527f2fda-219f-4eac-bf31-5f8c529da814","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1400","original_object":"UniProtKB:P31421"}
{"id":"5122c016-b9f5-4bc6-9d2c-121217dd9ab6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2215","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:1bff77c9-58e0-4d1e-9dfc-7e5312fa411b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2215","original_object":"UniProtKB:P47901"}
{"id":"b4e3d3ee-c60d-41b8-a393-16e590b27c2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311425","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:94ca9d39-df40-436c-98b8-1697b37b4569","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1000","original_object":"UniProtKB:P25101"}
{"id":"9e4d5814-4ade-4f4e-a956-26324a8950e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827346","predicate":"biolink:affects","object":"NCBIGene:11539","sources":[{"id":"urn:uuid:4369a581-5845-4e19-ad57-1ce288e4d9f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5622","original_object":"UniProtKB:Q60612"}
{"id":"eb17c73e-c818-4373-94c5-8bf12d1eef59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DL772G3NN7","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:cafe1461-3ef9-417f-9527-1a3bd5830f75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13213","original_object":"UniProtKB:P36888"}
{"id":"ed9bd275-7845-413f-ad89-a2acd68de685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:66B7UY5K7I","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:cefe862c-d2f9-48b8-88da-0b80530d7de5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7683","original_object":"UniProtKB:P21917"}
{"id":"4270de8a-f553-4fc6-ae4b-33d1291c557e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232716","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:0d489a04-a328-4316-8e21-413d4e0771f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12984","original_object":"UniProtKB:P00533"}
{"id":"3c906066-2a27-4e85-8941-da80d3005d47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9434","predicate":"biolink:affects","object":"NCBIGene:945","sources":[{"id":"urn:uuid:64980d57-9884-4b98-aedb-c35e1a6fc711","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9434","original_object":"UniProtKB:P20138"}
{"id":"e4c69d88-3da5-43bd-959a-5d77156b7cea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:311","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:361ad0c3-e197-4a5b-98c8-be42071d877f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:311","original_object":"UniProtKB:P11229"}
{"id":"103630ac-0628-4227-914f-df0d72a1fdac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9622","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:031347ad-fe65-466f-8e7e-60f209df443d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:360","original_object":"UniProtKB:P08172"}
{"id":"90e00a29-9ff0-4eed-a6c2-2de323f59a10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:7101","sources":[{"id":"urn:uuid:79741f83-8c28-4d5e-85b3-123c5191d9b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:Q9Y466"}
{"id":"26700db8-765f-437d-a648-e25faf010c0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1987175","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:75cb737f-7882-43ab-b043-b2760aab1531","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9283","original_object":"UniProtKB:Q13258"}
{"id":"11647230-491d-4ff1-b056-bb65f2f53d5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104131","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:641c50cc-6659-48b5-a8c1-aa28622706ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:79","original_object":"UniProtKB:P08908"}
{"id":"4bcaea1d-d54d-42f3-a946-2005a4a7b383","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:704f32b8-3a1a-4910-b0e3-2694ba2e3740","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P21817"}
{"id":"dfa54c2d-bbf3-49e9-bcc1-47f8618dcd46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993643","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:ec59cc55-6788-454d-8042-c434d0ce604a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12486","original_object":"UniProtKB:P20309"}
{"id":"ed1be10d-492b-4bca-ae47-2e13fc3be551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16219545","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:6bf01723-b794-4183-b319-180da854e6f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:337","original_object":"UniProtKB:P08173"}
{"id":"09af7698-1038-4203-9c34-6732d25a4d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WO97N24A47","predicate":"biolink:affects","object":"NCBIGene:325","sources":[{"id":"urn:uuid:ac7455c2-38b5-4ff0-9bd2-5d3cd6f70609","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8256","original_object":"UniProtKB:P02743"}
{"id":"895f1f68-77d8-4763-92aa-6ef25ba370d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:51305","sources":[{"id":"urn:uuid:78ccf01a-4432-4c38-abaf-9cdba5585208","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9NPC2"}
{"id":"5c3fd942-6f30-4c5b-943d-6495e7e571fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:2b00df70-c1f7-420d-bed0-eddaee172bbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:O95069"}
{"id":"d64852eb-e430-4e37-9ac3-5e1420ff272d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6135","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:a15aa5a1-dbb5-4a19-b656-f77c805e7a40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6135","original_object":"UniProtKB:O43603"}
{"id":"c8cff50b-24b7-4c62-8184-5713b7f04646","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:129ec894-3925-41b0-af06-e705e25afa4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P32305"}
{"id":"4b0d3773-735e-4d09-a7c1-8c38d10618ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:ca35e5b9-c350-4cdf-8815-144741d84448","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P41595"}
{"id":"e1769005-bb97-480f-ab11-29cb1dd8559e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O12H7VFU6P","predicate":"biolink:affects","object":"NCBIGene:57302","sources":[{"id":"urn:uuid:5c458d07-1e1c-461b-8d1e-dffe4855e8b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12751","original_object":"UniProtKB:Q9QZN9"}
{"id":"e97c2bb0-9449-461e-9ee5-0ebec2550bcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:970375","predicate":"biolink:affects","object":"NCBIGene:43847","sources":[{"id":"urn:uuid:4524a556-c553-4b90-9f71-38ff1d3af5ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8488","original_object":"UniProtKB:Q9P0G3"}
{"id":"564a6aed-5dcb-49db-bff8-6987fc4b35b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:636","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:0b9822a7-c665-4028-95f6-80391e84dc1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:636","original_object":"UniProtKB:P46663"}
{"id":"3067ccc2-76e4-4dea-abad-23fb5244ac7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RE0V0T1ES0","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:be1630ea-a23c-4958-8da4-2fb793ddd35a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12026","original_object":"UniProtKB:P10828"}
{"id":"0e7fae21-d831-43e3-88f2-df0e4d77fd8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:9f4fba9c-f2dd-44e2-806f-c17c7b661e20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P34995"}
{"id":"0a282027-6a47-4567-ae4c-3445b41ee0bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34879","predicate":"biolink:affects","object":"NCBIGene:157855","sources":[{"id":"urn:uuid:3728756a-01ac-4c6c-b432-5303fb69d116","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4272","original_object":"UniProtKB:A8MYU2"}
{"id":"85948216-ae40-46c9-ae04-a133c6428993","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:edfb1494-b7c3-4c12-877b-f09025c4f2a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q9NQA5"}
{"id":"ae463ef0-3e5e-4b77-b4ec-59ed1bca84d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155688637","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:f0418d1d-1c53-44a5-bd09-8f4124dc29e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13347","original_object":"UniProtKB:P24941"}
{"id":"91d9d624-e0c2-4514-aeff-39e06d94286c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:596810","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:a0600633-e28c-468c-89c1-e7262af728b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2494","original_object":"UniProtKB:Q8NER1"}
{"id":"cb1070ee-2c8d-4b13-b8fc-3ce07856636e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182436","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:e2cb5711-7feb-46c6-a8f8-b3542c061e0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7495","original_object":"UniProtKB:Q13547"}
{"id":"d2d21ea0-18fc-4556-8279-fcb1a3b859b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:378807","sources":[{"id":"urn:uuid:7ad59e7b-2870-4f72-a9fc-987e33f8e52f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:Q7RTX7"}
{"id":"0e23b1e9-95c3-4883-9c26-e95884ff0d5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6539","predicate":"biolink:affects","object":"NCBIGene:8111","sources":[{"id":"urn:uuid:e2b6b42e-bb86-4b80-bb2c-e98194fc6eac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5884","original_object":"UniProtKB:Q15743"}
{"id":"12f82989-cec8-4549-910e-b360989865f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3677653","predicate":"biolink:affects","object":"NCBIGene:84050","sources":[{"id":"urn:uuid:eddca72c-6905-4509-80a9-14a7552d1746","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9762","original_object":"UniProtKB:Q64610"}
{"id":"9e1b33b2-b4f2-4580-8307-28f9c12ecc17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P0FN522VTO","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:ee47e564-86b1-4a8a-aea8-dcad0c950010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8374","original_object":"UniProtKB:P50052"}
{"id":"913025c5-d4d3-4295-a8d8-cde3486ceb76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6070","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:77150d20-015b-45a4-b2fa-19ec42995e08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6287","original_object":"UniProtKB:O75762"}
{"id":"2e90e8cc-224b-4546-9b83-f2b969854782","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4X2F5X24UK","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:5dad475b-f20a-4b10-b613-8ebf57d18a22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1432","original_object":"UniProtKB:P41594"}
{"id":"c4dfa6ad-07e9-4410-809a-5f985a3c3802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73390","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:3d429dd0-4f9c-48ce-ac86-05aca70632ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2877","original_object":"UniProtKB:P06401"}
{"id":"3de908ae-2ceb-401b-b595-8b9eff1d1702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:65180","sources":[{"id":"urn:uuid:af590cd9-d7c2-49a6-b4e6-853e9604b8a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q63881"}
{"id":"0a49c307-ab62-4c79-9072-1441ae1c9932","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77260","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:ecc6dc0f-ff05-44cc-b50c-ab6880d8f07e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4279","original_object":"UniProtKB:P51788"}
{"id":"5bfbaa40-c4f4-457c-a514-2e6e2a2a59f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RE9JUR6NT4","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:242eefe5-3df0-4088-b030-31a04bd84f6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9783","original_object":"UniProtKB:Q8TDD5"}
{"id":"505caf62-a13b-49ec-9cb4-cd11d9d1d4e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:f5462025-905b-4384-96c1-c328b52dedb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P08908"}
{"id":"5cd343a6-d773-41f9-b21a-ee6814582f89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108245","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:b618f925-3953-46ec-bc3a-08ecf92c7a39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3078","original_object":"UniProtKB:Q02769"}
{"id":"bf7d81d1-60d4-46c5-9541-63c080f78a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AIQ4OWD0RA","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:67aab39b-dfb9-421c-a62b-70f4ef4baa86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8527","original_object":"UniProtKB:P48736"}
{"id":"31e9b967-ee79-4b29-ba09-7500f6412ad6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44156901","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:c78b12f3-ed83-4197-9c8b-492255a471ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9057","original_object":"UniProtKB:P48067"}
{"id":"d5aae7e1-397f-4c54-929a-238909a96eed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:b59bd0e0-e642-42c8-9121-32933ad1ad56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P17948"}
{"id":"442a4002-b21d-467a-824d-6184f673d6d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34725","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:2447c72b-79bb-4111-9199-592827313251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2403","original_object":"UniProtKB:Q13224"}
{"id":"76017da1-6d19-41fd-8bb8-c2c65a0ac112","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168665407","predicate":"biolink:affects","object":"NCBIGene:5566","sources":[{"id":"urn:uuid:6d2ea7df-373b-487f-89dc-410ccfcca6f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13089","original_object":"UniProtKB:P17612"}
{"id":"4a97ce37-8bc3-4440-b671-7aae6832190a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L8QUK35RX","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:77270c81-46c0-41a7-abf6-7459443dac77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11557","original_object":"UniProtKB:P56817"}
{"id":"cee3a89a-8fe8-4ee2-b4e6-2f7a927ea023","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10255","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:704a73cf-ccf2-4fb0-8907-9c637b9fef30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10255","original_object":"UniProtKB:P30411"}
{"id":"60d37dbb-27c3-4bb9-b45f-13f029a1203d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2266","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:7b2a9e79-7320-4939-adc6-1344cf3d685f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2266","original_object":"UniProtKB:P41586"}
{"id":"6fd9afc4-d363-4766-9fcd-24ce4ba1bd62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122666966","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:d5651215-4316-4379-84e9-d59389759b7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13760","original_object":"UniProtKB:P00533"}
{"id":"265062ca-ec78-4573-99e3-6f57f551be1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11611423","predicate":"biolink:affects","object":"NCBIGene:684516","sources":[{"id":"urn:uuid:3e00866c-9ce6-40b7-8eb4-28f8d5b63f8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2572","original_object":"UniProtKB:Q63734"}
{"id":"bc85fe6e-f649-4635-876a-d1117ae8eed0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163902400","predicate":"biolink:affects","object":"NCBIGene:121260","sources":[{"id":"urn:uuid:361659e5-cf5d-4695-bc8b-0c3ee1da2dc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13090","original_object":"UniProtKB:Q8N697"}
{"id":"8ad8c7e9-1beb-4af0-9d0f-41caeca84033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755057","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:567f9c72-50ff-40cb-80d8-685157e59523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3484","original_object":"UniProtKB:P30559"}
{"id":"ea30e095-0674-4e53-9e38-81d3f9a2c36c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44585949","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:fe1cf9bc-0d6d-4614-bf75-6bfeff1cce0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1748","original_object":"UniProtKB:Q15077"}
{"id":"946157a8-d37e-464f-b594-63269e5ec8e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600335","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:e9d6c0ac-e10a-42b0-91eb-ecb815fa494b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10549","original_object":"UniProtKB:O60674"}
{"id":"2fcfda0a-db1f-4b5b-a921-1672f9caf162","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:189R4J5E0F","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:b91a75d7-2871-48cb-9da4-686a8b7961a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:662","original_object":"UniProtKB:P46663"}
{"id":"1bcedc37-27af-42ee-9c1a-92537482f352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:87596969","predicate":"biolink:affects","object":"NCBIGene:7099","sources":[{"id":"urn:uuid:ff5a6819-7584-482f-b3bc-8a700d118ff0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10091","original_object":"UniProtKB:O00206"}
{"id":"ce3aad4b-53cf-4d63-9e1b-8a5998a947af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125516","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:f0856e22-e41d-49d7-8839-f35802a6dcf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1582","original_object":"UniProtKB:P20789"}
{"id":"75360152-abac-402f-8033-4b30e7a4e4fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81389","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:c944c4c8-ddbf-47a0-98a2-b5e185b248c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1248","original_object":"UniProtKB:Q9Y5N1"}
{"id":"75c79c67-4556-4c1c-96b8-06dd937d8810","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24752296","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:4292978b-eba5-4633-bbca-d3b6d9ed40c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7820","original_object":"UniProtKB:Q8NER1"}
{"id":"ce2f7c60-33f1-4061-9f45-69573596e93a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2187","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:90a78539-19a7-48a3-9bb4-68005bf92840","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2187","original_object":"UniProtKB:P37288"}
{"id":"b0d80f66-7b7f-4f34-94c1-9380089df5fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135929","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:2d411cf0-89e7-4069-b624-4ce31d7a9850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:493","original_object":"UniProtKB:P25100"}
{"id":"cc413e5b-97a4-4739-af26-b3213cf3b1a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:5cc367a8-bb23-4a55-8755-3037ba97be90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P00533"}
{"id":"377ea60d-c7b5-4af8-8280-8d6025b5992e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53232451","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:c38a976b-9b61-4087-830e-2df8aa31971d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8123","original_object":"UniProtKB:O60674"}
{"id":"0362580d-d57b-465e-84ba-393df223ef80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311175","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:0288d624-69b9-4796-a1e2-58252249f84a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1938","original_object":"UniProtKB:P43117"}
{"id":"d175d848-17ee-495b-8938-d7feed322189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DO9M06BFRJ","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:1193a092-a295-4895-8973-b517d99e66f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3297","original_object":"UniProtKB:P21917"}
{"id":"9f603873-2b04-4973-9b7e-eda1ca76ac8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:d7dcf7f2-8c0e-41c2-a2da-c11c1b87816b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q969S8"}
{"id":"60391d03-f2c9-4e2b-be17-045a708939d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5790","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:8771fc54-c84c-4744-9148-fbe7092b25c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7082","original_object":"UniProtKB:P41145"}
{"id":"536e7e82-8f81-43d2-96bd-3fedf9d69777","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188719","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:ea8180b5-a8b8-406a-8f1b-55b8787fba60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8376","original_object":"UniProtKB:P13866"}
{"id":"de8dc474-7dc7-49d7-a8f4-4a7bf54376ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7640","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:0d31f50f-1a36-4213-85f7-48ef1ebea946","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2404","original_object":"UniProtKB:P23975"}
{"id":"745df31b-9db8-4c68-b78f-1d18f7294dcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72199906","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:b384f7ea-e373-4e3c-a1ce-632f7b4220ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4258","original_object":"UniProtKB:P39086"}
{"id":"0f73f1d2-5d98-4ece-bd47-71a0c941af0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:c9ad9cf4-2244-4c3d-a20f-0e065777e6c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:O43603"}
{"id":"7252c199-a7e4-4c8c-b1eb-fbb67c855e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2525","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:e535029b-a32a-4ccc-b287-939e529532de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2525","original_object":"UniProtKB:P78348"}
{"id":"e12802dd-0d11-4dc3-ba0f-53d33caa012c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699449","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:e9a26ef2-67d1-4ca3-874d-f428eaf1f1e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11146","original_object":"UniProtKB:Q9NRA0"}
{"id":"08727cca-9a9b-4786-aa5c-b4a4f817d2f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:770","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:8153a058-70e0-403f-b39c-bc2b1817e846","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:770","original_object":"UniProtKB:P49682"}
{"id":"4a8cbdb6-0b71-4e8e-8ca6-f84899a441cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73774630","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:3250ce9e-d857-4455-8708-0783bc66ea59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12301","original_object":"UniProtKB:P08485"}
{"id":"36263627-d8fe-460a-be22-0ffe99efc0da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167662","predicate":"biolink:affects","object":"NCBIGene:369","sources":[{"id":"urn:uuid:5615af9d-5125-412f-a7d3-194f5c3b9d8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8943","original_object":"UniProtKB:P10398"}
{"id":"aed6b671-0274-48ba-8622-43ed319a64cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:c839e332-a2f7-4180-84f3-ad7381a425c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:P45983"}
{"id":"af5bd0af-7399-45e4-8938-be780b40c3ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44382842","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:21c4a51b-ea1c-4a6d-b6a5-61b698085817","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3106","original_object":"UniProtKB:Q02769"}
{"id":"cbd7da6b-6fad-435b-9bf9-7d951fa2f1d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3892","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:80c60d52-1e6b-41ed-91e6-8b895f046885","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3633","original_object":"UniProtKB:Q01726"}
{"id":"df4d5ccc-33df-43f3-831a-1d06045effb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:798","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:6117398a-3c03-4bd4-becd-72992812c24a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:798","original_object":"UniProtKB:P51679"}
{"id":"aceb4693-25a1-4a44-b259-05ff25f0e5fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56599309","predicate":"biolink:affects","object":"NCBIGene:5340","sources":[{"id":"urn:uuid:92e7bac6-8046-42cf-b6e4-f2854bf04e99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6537","original_object":"UniProtKB:P00747"}
{"id":"f676cbbe-0691-445e-9c06-34dfe109b1a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229910","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:adb54681-5828-400b-8873-a90cda1fd36c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6637","original_object":"UniProtKB:P21397"}
{"id":"3b86db1b-27a1-49ef-a339-117ec2cab8b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177470","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c9b4604a-1c04-43a7-bf81-f3f25eb7452a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1894","original_object":"UniProtKB:Q13258"}
{"id":"9e136bb6-3681-4cdd-9ca2-2e9418751e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71660551","predicate":"biolink:affects","object":"NCBIGene:7184","sources":[{"id":"urn:uuid:f8069b2d-9d1e-4730-adf4-6022de114271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9227","original_object":"UniProtKB:P14625"}
{"id":"03c4b832-2dbe-42cd-863c-606e854e2ed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16112","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:9607f1b4-4603-4e2b-b366-5dfaf150e076","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12477","original_object":"UniProtKB:P18031"}
{"id":"7889ef8c-ed64-41ac-a06a-ac16e541c699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:03cdbd4b-72f5-4f11-9240-ae60a620621c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P32240"}
{"id":"5d4b5fba-5dc9-45f5-9b5c-27c797a5b656","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24204784","predicate":"biolink:affects","object":"NCBIGene:5728","sources":[{"id":"urn:uuid:8bf5f7f1-d1f2-4e54-9764-a9d43deec09f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8877","original_object":"UniProtKB:P60484"}
{"id":"bf4a097d-389a-4010-bc7b-d0fb73aa33bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10752","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:4d632b38-1bd3-44ee-b23c-7565f86087ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10752","original_object":"UniProtKB:P51681"}
{"id":"3e0f9c5b-26f9-4469-89ca-a5982885fee0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73357","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:186cab6e-223a-4adb-a118-c29d4953150a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1655","original_object":"UniProtKB:P33534"}
{"id":"f4a50050-83b4-42e8-9955-36ef062f6051","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4896","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:5d75cceb-1df8-4671-88c1-c861a4eb39dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4896","original_object":"UniProtKB:P20594"}
{"id":"bdceaaaf-eafe-4700-b500-95fd51c363be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4N6KQ7D685","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:0482d992-1998-4141-98dd-fa00627d680e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11506","original_object":"UniProtKB:Q12852"}
{"id":"d8bdded1-7de2-4193-b28d-5d183a24dc67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310960","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:81308699-9da1-47bf-af6e-522130f0fa08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:459","original_object":"UniProtKB:P30542"}
{"id":"02f5b79d-377e-4eb9-9f86-be8b32a9b466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91327","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:6061080c-e189-4911-9ddb-246061394839","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6058","original_object":"UniProtKB:P35916"}
{"id":"27930c45-10ed-465f-9a73-1893b11bf4aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13785","predicate":"biolink:affects","object":"NCBIGene:25084","sources":[{"id":"urn:uuid:a543dfd4-0af7-41ce-bd56-044603768ee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13785","original_object":"UniProtKB:Q63257"}
{"id":"bb2021bc-d268-4eef-9668-024b1f4e5775","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9936595","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:f66a6e36-b4bd-4ec7-83f5-ece85e63351e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1921","original_object":"UniProtKB:P30557"}
{"id":"12c71619-0ea2-4f76-89fa-cc0ba8ff0bc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67116280","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:44f93ea1-ce86-4fe8-8eee-777c38799f28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9308","original_object":"UniProtKB:O43614"}
{"id":"5ad2ad8e-5272-4b56-9fdd-0771951f0490","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61049","predicate":"biolink:affects","object":"NCBIGene:2280","sources":[{"id":"urn:uuid:6961fa5e-1930-4faa-a046-70de056044a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6784","original_object":"UniProtKB:P62942"}
{"id":"f62c2fff-1eb7-4c84-94be-b9dea7d0b96d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4545574","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:b32b3cce-a897-42ff-a695-b7bb9881b5fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1406","original_object":"UniProtKB:O00222"}
{"id":"81190e6b-89c4-4155-8e9a-078117714a4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188072","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:3f4cdf7e-92fc-41ba-b393-77a25ec43451","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:67","original_object":"UniProtKB:P35367"}
{"id":"2ecd33c0-ed4d-4d87-84d5-e6ae77a0442e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c6be2f38-65ae-4b2e-b0fc-bef4a32d7c20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P28221"}
{"id":"b00681fe-bb30-4870-aba8-9581b026daa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13162","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:cb3fde6a-2c15-473e-9ed4-8701618edeff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13162","original_object":"UniProtKB:P08913"}
{"id":"510f19c9-bac4-4103-8aae-614ef17ea5b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S98NFM1378","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:59290f1b-6a7d-4ff1-a2a5-a9c6b5dbeb44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7698","original_object":"UniProtKB:P11309"}
{"id":"77c69894-788a-4468-a34d-10a04df373ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169155658","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:454897cb-f730-4b5a-b783-59625685a720","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13841","original_object":"UniProtKB:O00444"}
{"id":"3055f9ea-d2b0-41cd-b0e4-6b0d9684fc25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8333","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:42e4ec47-d585-49ef-8731-f2f2d746e778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8333","original_object":"UniProtKB:Q8WXD0"}
{"id":"30d52304-a97c-4b01-a3c0-055e077344a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92283","predicate":"biolink:affects","object":"NCBIGene:13609","sources":[{"id":"urn:uuid:621694f8-11c8-4d79-b906-10022d23867f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2926","original_object":"UniProtKB:O08530"}
{"id":"7f7a28ab-daa5-4e51-9933-7ab69b139466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6U9WP10T7","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:067e983f-7bc7-4aab-87aa-9def5a281b74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7885","original_object":"UniProtKB:Q05397"}
{"id":"bbf86785-ea05-444c-9748-5d69d87f911c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44811","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:3f7c3176-a3dd-46de-bff8-219c47315fbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1831","original_object":"UniProtKB:P25105"}
{"id":"bbd57f8a-6be6-4475-96ed-849e339e5173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18344","predicate":"biolink:affects","object":"NCBIGene:367315","sources":[{"id":"urn:uuid:225187a9-9f93-4c2a-b95e-a3a9d6d9fc9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2918","original_object":"UniProtKB:Q33BM1"}
{"id":"95b71448-e1bb-42d4-aab5-5770927e48b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13396","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:d77d7de8-f688-4eac-9bda-07d88c242778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13396","original_object":"UniProtKB:Q15116"}
{"id":"164e1dd5-277b-44dd-8902-ed0a9fa93700","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:9d97041e-0ffb-4ffd-be66-10a92b2976f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q9UBN7"}
{"id":"72efa8f0-2591-489e-9eaa-78f7812f086f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52946595","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:54165865-0aa0-4143-9591-5e74ee95e64a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11515","original_object":"UniProtKB:P07711"}
{"id":"38b89382-5da8-49d2-b3b1-37779409dbb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:57165","sources":[{"id":"urn:uuid:891420df-97e7-4890-b3f0-5bf38cfc67e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q5T442"}
{"id":"21744330-94c5-4e95-92c3-aad25b86912f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:11d1f6a9-1b35-4851-83ba-7a16c9355f06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P31388"}
{"id":"6aa8b993-2411-49a0-a70a-66187ce18f3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3171","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:be03b561-23c7-4392-9149-5f575e0f66aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1603","original_object":"UniProtKB:P41145"}
{"id":"781374d1-76a3-4576-99ed-46f2ea1534f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2184","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:00f6e33f-5648-4545-a3db-1a2cce7db4cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2184","original_object":"UniProtKB:P37288"}
{"id":"bafdc50d-ad59-4a33-a66d-fa42d0217bff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146267141","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:ff38ca71-d2d0-43c8-a320-445cb8b0e3b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12075","original_object":"UniProtKB:P42336"}
{"id":"1419ad37-a3a6-4ec2-85fd-ee9808aef0ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:b0797e42-207a-4733-98ec-e3bb8f2ffd72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q9EQ31"}
{"id":"ef41ab12-abdf-4b33-83b8-524f671fdc24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611895","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:bc4e635c-f94f-402f-bc19-442fe446407e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9998","original_object":"UniProtKB:Q15391"}
{"id":"e78e3f60-3c12-46ef-b9c4-5b1f949e2cac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12990","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:dd52e6c8-665e-4859-9bc8-219e3ce30fb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12990","original_object":"UniProtKB:Q15116"}
{"id":"efde7055-5095-4820-890d-04f1a810942b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5YG6JK4ECM","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:70d994a1-8a5b-46b2-bb30-a0c1795ab99a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3262","original_object":"UniProtKB:P08172"}
{"id":"df358e80-a86f-4e02-87a5-c509ca47ed94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76849261","predicate":"biolink:affects","object":"NCBIGene:24412","sources":[{"id":"urn:uuid:3f09e1fe-7329-4d90-9ad1-944e4d91220c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7843","original_object":"UniProtKB:Q62645"}
{"id":"50ca21f7-a171-4c53-8929-001a13401c22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B0J1D1S3EI","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:ffe7d68c-8954-405c-b191-ecb7aba7b551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11720","original_object":"UniProtKB:Q13224"}
{"id":"38bf3f78-f95d-497a-9598-e2b3e4021225","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15512229","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:c11c7f30-2793-4a4e-80d6-48f3779ea56e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8864","original_object":"UniProtKB:P41146"}
{"id":"f255348e-ff4c-46c2-9fdc-3f15f9369c3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JUA77QEU32","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:f789d193-3798-41b1-8b6a-b6d852303810","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:272","original_object":"UniProtKB:P32304"}
{"id":"7aaf344e-b423-45f9-8f0d-bb6a454535fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F64QU97QCR","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:da3d6bb0-9d05-4d60-83e2-0c97b4775827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4172","original_object":"UniProtKB:P21817"}
{"id":"90ad9ab2-7260-4c5a-9848-b0e76877387e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57381425","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:77264af1-70b8-4c60-9600-ea87917e147c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11120","original_object":"UniProtKB:Q9UBN7"}
{"id":"490fc013-d77f-4384-852d-d986870b8468","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11436345","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:b793ee8c-360c-4b52-a3bf-6547c2ffd511","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1599","original_object":"UniProtKB:P49019"}
{"id":"cfa68c8b-e8e2-41ee-ba50-36990801568c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312460","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:5ab7bd3f-f88e-42c2-880e-1526c2147497","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13326","original_object":"UniProtKB:Q9NYV8"}
{"id":"936538ca-c91d-4412-92d1-fe6e4f88242a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3558","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:7ab31385-54e2-45af-97bc-596e56c3d284","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3558","original_object":"UniProtKB:P32239"}
{"id":"9f09b2ae-a034-445a-8286-8d7a54fda9f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46946406","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:422b58af-aa1c-4474-9757-253a53eb9a3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6414","original_object":"UniProtKB:P41594"}
{"id":"2ddec9d6-f08e-4b88-86bb-4794e01dad31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92168","predicate":"biolink:affects","object":"NCBIGene:1452","sources":[{"id":"urn:uuid:fb2632ec-9649-41dd-8d76-07b17d49f128","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5985","original_object":"UniProtKB:P48729"}
{"id":"fa5fa8d6-b753-419a-adab-3badd1b1c1f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9916282","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:dbf4e6d0-7bb9-49d7-858b-2df2b662c475","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8355","original_object":"UniProtKB:O14965"}
{"id":"47889388-a20a-4ad0-a9db-4957e2c022bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91556","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:2699a528-9ed8-4880-8711-3b527b16023e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:161","original_object":"UniProtKB:P28223"}
{"id":"453ab883-09ea-4a4d-abd9-26a015a9f1b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9808643","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:92318975-ca86-4564-a3d2-e1ab5ede59fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5844","original_object":"UniProtKB:P43115"}
{"id":"e735da5b-e7a1-4aca-a0c5-63ed72489641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311229","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:fc966f7a-e960-4489-b21f-e26454a0de00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1931","original_object":"UniProtKB:Q62053"}
{"id":"ee8f54f4-3050-4e75-8441-f5967ab00f33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2547","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:bed6b173-721c-4664-b234-27ef5b90d27f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2547","original_object":"UniProtKB:Q17ST2"}
{"id":"8cae8598-c0c9-4907-b6df-6b90b4213fe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153610906","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:7cc46808-4ca8-4dc8-a116-8d8ef445131b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12484","original_object":"UniProtKB:P45983"}
{"id":"d11ca747-66f8-4215-91ff-0fa236a6114d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:70c7fbaa-c823-4429-af37-e49c070b1810","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q14330"}
{"id":"5b777679-4e09-464a-972b-22c785b741f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9833","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:2a513e94-1eee-4127-936a-86018baddab9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9833","original_object":"UniProtKB:P11836"}
{"id":"9cce326b-ba3d-4fec-a88f-e954eebf08ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2159","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:198e57f5-6630-4c64-b8c1-66f71847927a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2159","original_object":"UniProtKB:Q9UKP6"}
{"id":"d620445e-8664-4060-a1ba-472f037aad3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68642","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:646d9231-3c0b-459a-8077-ac2203540152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6745","original_object":"UniProtKB:P05093"}
{"id":"db9cf63b-4414-435e-b7af-914df2da5d3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10591800","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:68da54c2-64c8-4f5c-a6d9-f1a36bf85381","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:82","original_object":"UniProtKB:P08908"}
{"id":"eecf3336-637e-44b5-850d-b4076b210578","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C4V974V932","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:96031f19-d2ae-447b-b689-8b2455e28eb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4844","original_object":"UniProtKB:Q9Y6L6"}
{"id":"c8812e94-bd41-4e0b-ac7e-28f16b07e7e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AVK0I6HY2U","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:451ea896-1733-4fa9-8b55-0a69e8fad1b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8299","original_object":"UniProtKB:Q03431"}
{"id":"0dabbe10-3b74-4bc3-bcd0-51c63b4fee84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123984","predicate":"biolink:affects","object":"NCBIGene:57657","sources":[{"id":"urn:uuid:e946af70-57f8-45fe-9c4a-6b4794943a81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2359","original_object":"UniProtKB:Q9P1Z3"}
{"id":"370806de-385c-44a0-9c46-c54a13994e37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6804","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:feebca55-e0eb-4fad-9477-1cead14f68ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7438","original_object":"UniProtKB:P08912"}
{"id":"57c9f928-997b-4fa3-a850-fe4e5a7b6b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:2fa913ab-8adf-40fd-a038-0bfedbd275ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P42338"}
{"id":"6068abe9-8549-4990-a934-f7a56e52a8ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1272","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:4b438350-f992-475f-af96-6ebb6d560e2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1272","original_object":"UniProtKB:P51681"}
{"id":"f2c074f5-1d3e-40c4-b96d-02660741bebf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6073LCU8U9","predicate":"biolink:affects","object":"NCBIGene:2155","sources":[{"id":"urn:uuid:f5ee9f66-62d5-4d8f-a63c-b935a832e000","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11585","original_object":"UniProtKB:P08709"}
{"id":"47fed04f-7350-4324-8c0f-44fc9895c66b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:6cdfdff9-8c6f-4b83-b064-e72320569c34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30874"}
{"id":"e38082eb-c344-4b5f-b535-3d4d6bf84f03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4345065","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:b8670136-e1fd-45d4-8b35-9dff71810b56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1093","original_object":"UniProtKB:O08725"}
{"id":"dd9cd919-2c97-4cdb-abec-0324471d251f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10450926","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:66752aed-2e1f-4ec7-83e7-84cfd7d04748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9610","original_object":"UniProtKB:Q07343"}
{"id":"e1d14fb5-78da-4a72-9a71-ca154cee5830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71553154","predicate":"biolink:affects","object":"NCBIGene:9448","sources":[{"id":"urn:uuid:f28b38f5-fa9b-4fa1-866c-e0f4d191b5a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8135","original_object":"UniProtKB:O95819"}
{"id":"ee79cef4-dc72-4c9f-a452-171325655fb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49872868","predicate":"biolink:affects","object":"NCBIGene:1558","sources":[{"id":"urn:uuid:72a5db50-2f95-4084-bd0e-9131d8e198d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8777","original_object":"UniProtKB:P10632"}
{"id":"ea95aa88-8390-4bab-a273-6b6d88bb7c08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177493","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:b97f6537-f3c4-4e90-9fe5-2c0554680f95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6489","original_object":"UniProtKB:P49768"}
{"id":"eb4d4f2a-d21e-4e01-a7ca-a18812324706","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2J6DQ1U5B5","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:eb9f2db1-0f2e-43ce-90c9-9cf524db637c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2297","original_object":"UniProtKB:P46098"}
{"id":"1930c401-eef9-4ac6-92cb-86747df12fe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71464","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:1fb2d71a-d39f-425a-8609-a43bacff20d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3622","original_object":"UniProtKB:Q9Y2T6"}
{"id":"bb73ee83-e41b-4795-9bfb-e302f484689a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:16514","sources":[{"id":"urn:uuid:77ed328e-460b-4603-b4dc-f93c024b7847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q61743"}
{"id":"0e43be2c-3a08-4475-bdd0-442b9dd0fbe1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24944925","predicate":"biolink:affects","object":"NCBIGene:4217","sources":[{"id":"urn:uuid:1832c645-6ba2-43e0-980c-2cf9fbf466b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8133","original_object":"UniProtKB:Q99683"}
{"id":"db190faf-6c01-4f36-86af-5ede9a9a2c81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15366","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:be89779d-db28-4d67-a05b-986c9c4ca91c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1058","original_object":"UniProtKB:O15552"}
{"id":"32548956-6652-4e19-9138-fea0411b37f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10253","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:e3d99828-1c86-40cb-8c66-04c3f705a108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10253","original_object":"UniProtKB:Q96P65"}
{"id":"1b125e14-a266-4847-b5d4-4b80a26b8c80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10259588","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:dcd279de-4f4f-4ebf-a026-17a99db0975f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:363","original_object":"UniProtKB:P08172"}
{"id":"c65cc944-1819-4dc0-a63f-dc8d9fbcc461","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611885","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:1703dc9b-7a55-4da9-9948-e89f0623a365","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9961","original_object":"UniProtKB:O00329"}
{"id":"f89cd7be-8cd8-44b1-af33-ba8b571e9b0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37537","predicate":"biolink:affects","object":"NCBIGene:29713","sources":[{"id":"urn:uuid:2a5c0c67-ed0f-47ad-9ce1-9b13b3a73e7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2341","original_object":"UniProtKB:P48548"}
{"id":"9ae336ce-2cae-4c24-baec-151c6d940fd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:994","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:54a4359e-a7ab-4058-8bb3-1b7c2e7db34e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:994","original_object":"UniProtKB:P25101"}
{"id":"27f568c2-4aaa-43e1-95b6-3c76c087f856","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6839","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:ab7eb3f1-da5b-4123-a01e-424323c51fa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:483","original_object":"UniProtKB:P23944"}
{"id":"e854fa34-c860-421b-b56e-2f9c9d40cb22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229220","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:2eea73c8-2ec0-4a86-9e47-0d3323c50e2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10316","original_object":"UniProtKB:O60674"}
{"id":"9a36c108-a138-4acf-9490-0cb6d2d2cfc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:193485","predicate":"biolink:affects","object":"NCBIGene:6510","sources":[{"id":"urn:uuid:b080d6d9-5dd7-401b-b0dc-906a3ef9d882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4500","original_object":"UniProtKB:Q15758"}
{"id":"807e6fcf-db91-4272-a49f-56201b4b003b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1994","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:88d563ec-16ae-45c9-b3d2-2dcb1307a20e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1994","original_object":"UniProtKB:Q9HBX9"}
{"id":"91598ca0-e490-4cbe-b528-0055c05a17c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:98780246-1891-449b-b3dd-187e9581ce29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2351","original_object":"UniProtKB:Q00195"}
{"id":"58efe030-db4c-4bcd-b3df-36c4885b196a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2533","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:eed6578a-1991-4e11-a931-596258c64942","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2533","original_object":"UniProtKB:P54282"}
{"id":"e7021601-be89-46bf-ab7d-86ca0ce8e54e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:c7696c26-5ba2-4358-8b22-9bca459feafa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P48542"}
{"id":"20dd4639-0ac6-4f19-bbac-408872914400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86YZ7HCC8V","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:64717056-0ae2-46a0-bf43-e3f6b065a902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9432","original_object":"UniProtKB:O60674"}
{"id":"5afcbb28-4d9f-4e09-9ea0-29145a2136ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73295","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:268e25a5-e4c5-431a-8cf9-865bddfaa7df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:733","original_object":"UniProtKB:P21554"}
{"id":"54df06bd-e739-4fcf-9b75-607003b46ab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3W2X0WGW6C","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:ad0d3a41-92eb-4380-95f1-15e93a41e21f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5655","original_object":"UniProtKB:Q9NRM7"}
{"id":"9628c1a1-5831-4027-8d12-34e5c1f72e07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:518962","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:0c322f43-a82c-48b5-b308-fbd5e729ca5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1625","original_object":"UniProtKB:P41145"}
{"id":"d4cc7bb5-a112-44b4-b9a4-2856857fb9f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1792","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:c939abe5-f3cd-407f-96d1-57fdac52a95d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1792","original_object":"UniProtKB:P25961"}
{"id":"5a36b1a6-4d04-49ad-afc5-02b8160f70ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1004","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:4435c89c-2147-4f47-aecc-956498ce3ed9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1004","original_object":"UniProtKB:P24530"}
{"id":"ba4485c4-d996-421b-ace6-c203bfe861f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142452","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:7332c224-c54f-4c37-8d8c-84efb2a28cfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3469","original_object":"UniProtKB:P35348"}
{"id":"cf7beaaa-8692-4bdf-8ddd-8660dd49435d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:a6f0e12f-80d5-427b-bd39-0375cfc14dd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P35349"}
{"id":"4f78897e-171e-4db7-817a-27e784bbf91c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311122","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:ca2ef293-88e0-4940-a03d-4624dfd1fcf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:581","original_object":"UniProtKB:P21730"}
{"id":"09a39b23-e8bb-4484-bc5e-7d1d82d8a274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:455J2479FY","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:dee83f01-f519-4510-be9a-dff8176bf7e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9115","original_object":"UniProtKB:Q15910"}
{"id":"bbd89778-08ad-40d3-ad2f-99b1195dab3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:772CP7W12N","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:508b82b5-6be0-4658-bfb3-353f0775de29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:888","original_object":"UniProtKB:P30551"}
{"id":"5655d1c7-bf6f-453b-83b1-3af5a5171cb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11537456","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:534eea1e-4206-41b8-b8dc-0cb48790b9a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6354","original_object":"UniProtKB:Q13255"}
{"id":"50dc75f4-1db1-4570-8f6d-63bd9f63aca0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4160662","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:cf1beb9b-f926-4f50-b753-9df23d4837fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10063","original_object":"UniProtKB:P50750"}
{"id":"061b6d90-23e7-444d-a882-bf7f91c3f91a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081963","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:20298988-deeb-46b7-9652-5d42f69407e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9883","original_object":"UniProtKB:P61073"}
{"id":"77645470-4534-4404-9b27-ce3a2931d65b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7D0YB67S97","predicate":"biolink:affects","object":"NCBIGene:941","sources":[{"id":"urn:uuid:81905d86-f470-4389-8621-23818b4777f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6891","original_object":"UniProtKB:P33681"}
{"id":"abc2cd60-2ab2-4093-8390-cb24bd65fc42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:752c8867-54ac-4fd6-977d-7d54e3243339","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P51813"}
{"id":"386e9608-72f9-4197-9440-ed30f4ec0523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XK5ILZ28KI","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:3479d735-09ba-4d53-bfc5-56a831051038","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10452","original_object":"UniProtKB:P41145"}
{"id":"0be77d0b-e900-41ea-8e07-6a90fcfc31bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2028","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:f295752b-cc75-4307-8352-2cf4cdab9b59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2028","original_object":"UniProtKB:P30872"}
{"id":"61ac3a0f-5f7b-4ef8-ad78-787bfa9605f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:736736","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:6f5d7170-a3d0-4e5a-ac7d-36020d8c7e33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:400","original_object":"UniProtKB:P25099"}
{"id":"8c1d5659-e4b8-4627-ad7d-da10adf43479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947515","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:ea5fa403-8b19-4667-bf2e-16ae5ec0a558","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9916","original_object":"UniProtKB:P42338"}
{"id":"535ec881-c1d8-490d-a72f-2a5b4cbd4542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:02Y3Z2756M","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:5475d6b0-ab42-4575-a185-342def815757","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9427","original_object":"UniProtKB:P33981"}
{"id":"6d41bc89-449e-4519-88f4-754fc60a1b08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1495","predicate":"biolink:affects","object":"NCBIGene:2832","sources":[{"id":"urn:uuid:a2a088f8-44ec-4e32-bde2-45021ffd6b3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1495","original_object":"UniProtKB:P48146"}
{"id":"0aba125d-6bba-4432-bd64-6ee99d12d05d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122163152","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:77b1b2f4-ddfa-4aea-aa84-c59eccd83d42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9571","original_object":"UniProtKB:P42345"}
{"id":"d9a001de-f909-4a77-9004-63cc34e80c50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:1564ff10-048a-4ce9-90f8-44dba9a85eac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:O15530"}
{"id":"f58791f2-3f68-47a6-a24b-8a06ddb0265d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:146219","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:ab1e9f2c-6e77-4932-8667-b5905cf6806c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2519","original_object":"UniProtKB:P22002"}
{"id":"d3daa408-d3a0-4f6b-a262-f5d02e8023e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:632","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:88a17241-2af5-4cad-940c-82933387acd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:632","original_object":"UniProtKB:P30550"}
{"id":"e1e91c1c-d376-4bcb-9e8a-49610834b682","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:777","sources":[{"id":"urn:uuid:b095b340-e60e-43cd-9d31-63e05b7e3ed5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q15878"}
{"id":"50a5bd64-a9fa-4bce-a206-0eb5a7cd303a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MB9LR353F8","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:166a4986-3283-458b-9a25-748cec6228bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2812","original_object":"UniProtKB:P19793"}
{"id":"66a0e256-917c-443b-a1bb-541f2605288f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143102","predicate":"biolink:affects","object":"NCBIGene:6868","sources":[{"id":"urn:uuid:ffb45a01-9037-4b8b-9e01-6aaf395b3241","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9687","original_object":"UniProtKB:P78536"}
{"id":"ab75f4d5-bab4-4a47-b6de-e8f7c0cc1155","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:af04e5b6-08b4-4e2d-8339-1a678bd37346","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P18089"}
{"id":"b724c0b7-2744-4e65-abb9-0af800e2bce4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6610278","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:189482ad-3ea0-48e5-8619-72f9e3a2e973","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5930","original_object":"UniProtKB:Q96GD4"}
{"id":"490ef48e-596e-4e9c-96aa-3dc154258cd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64110","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:01725ddd-9591-4126-953e-e45eb67ecae9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2819","original_object":"UniProtKB:P03372"}
{"id":"70f672df-be33-4faf-9624-240d2958e3e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167668","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:73c58176-e6f5-416b-ac7f-a6ff8ee7329c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6625","original_object":"UniProtKB:Q9NRA0"}
{"id":"c40af2d4-aff3-4999-9baa-b186381a7889","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3L098A8MPY","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:e484bb77-70c4-4f35-aa14-8db1ca50d7af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5751","original_object":"UniProtKB:P25103"}
{"id":"fdb2ac67-4d56-48cd-8470-a16f614ad60f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:6a87074b-56b4-43e4-88ee-d0d6ff6c64c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P30874"}
{"id":"d6d01b53-1c60-4a80-9bd5-de185265de1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:84694","sources":[{"id":"urn:uuid:ba9bdfa6-59a1-42bf-9e9d-b66658f9d724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q969M2"}
{"id":"6e9b7766-c497-4391-8fc9-600b68f51192","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:4638","sources":[{"id":"urn:uuid:ed77d2d0-aaae-4568-94e8-8a8a8fb62f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2351","original_object":"UniProtKB:Q15746"}
{"id":"3c776b00-a055-4b49-be84-8e0ff19678b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:715924","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:ff69ab0f-6397-4ee5-b898-50068bbe1f1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7656","original_object":"UniProtKB:O95259"}
{"id":"3ae87652-3925-4882-a18f-c7e158d6f6b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50169","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:3386f0cf-408f-4c5f-b481-988601e6e407","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4108","original_object":"UniProtKB:Q16445"}
{"id":"0826c8a4-6461-4db2-b704-e8214decf364","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122552662","predicate":"biolink:affects","object":"NCBIGene:56749","sources":[{"id":"urn:uuid:5e4c2d1f-3404-45c1-a52c-b0001651077b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10020","original_object":"UniProtKB:O35435"}
{"id":"3104ba62-f8b3-4f72-94b4-fb8a18e40e6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5574","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:49f21253-04e9-4af5-bafa-d5b8ff407421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5574","original_object":"UniProtKB:Q03431"}
{"id":"d5a550cd-b6c1-4e22-8072-38bdff31b24d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:60a3f34c-30a2-48ac-b170-8696979606fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P30994"}
{"id":"ae9133ba-ac5b-42cb-8eda-6a4cd0678561","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86302487","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:7072f623-c5f9-4ab4-9c72-b3e8f0672319","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13467","original_object":"UniProtKB:Q08499"}
{"id":"5c8346ae-b2a9-4c7b-9f0b-41f69bfae929","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3871","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:364c9643-dd54-41c0-b708-492b0467f0cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3871","original_object":"UniProtKB:P28336"}
{"id":"fe12f60b-6710-42e6-8ea9-37a368fdd6f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71613550","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:203ed809-6624-4bc8-9c7e-48480a1be60a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12380","original_object":"UniProtKB:P04626"}
{"id":"6f3ae693-2c9b-4271-8c1a-7335145718ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25016538","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:db20f56f-4ff2-431f-9c81-942538e03c1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5862","original_object":"UniProtKB:Q923Y8"}
{"id":"1657e5ac-1708-4261-9fe5-c2fc7461b626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125406","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:4a58ec8a-0b89-4dd7-99ec-3f3dcfda3c75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:132","original_object":"UniProtKB:P08588"}
{"id":"ce2a5beb-9dd8-4964-b817-083c14bfbb0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1732375","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:b776bb89-596d-443d-b2bd-d53c2951b2aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7720","original_object":"UniProtKB:O43497"}
{"id":"4fc91c27-f9f3-4f01-9505-b3af7f13bdba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9937377","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:b24436fe-2850-495e-895b-8cac5179e003","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2956","original_object":"UniProtKB:P51639"}
{"id":"2c648395-96cc-4cc7-b538-24a1b6f430f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132086","predicate":"biolink:affects","object":"NCBIGene:7101","sources":[{"id":"urn:uuid:a3675857-33cc-4532-bc10-31365459b56c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2641","original_object":"UniProtKB:Q9Y466"}
{"id":"94b1e2dd-e4d7-4bd4-bf97-4978c2056363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:7b6f7998-b557-4bc7-99b6-f773c0d42007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:Q15303"}
{"id":"997f5179-7c42-46fc-b261-17c32db014b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27485","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:f2c7d13d-821d-482e-b7ca-c347d3cafdb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1885","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"c12d6cb5-c70b-4b50-9471-e9b0656bee3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:0b5046d1-ff2a-4540-9927-9429457450a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P31388"}
{"id":"37e70805-f69c-4e19-b9e0-21368d549904","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56847486","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:0b5d6580-7c3a-4178-a7fd-fd491e84117a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8247","original_object":"UniProtKB:Q06418"}
{"id":"ad6c1516-6c4d-4367-a724-6840681d7f91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D6OMY2L0WA","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:9a87eb04-6966-410b-97b4-a511b9dfa857","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11442","original_object":"UniProtKB:P11836"}
{"id":"1b8ae145-7afa-419d-b0c7-378824b48fe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:4e50edb4-ee80-4a42-b85b-1a5abd1c03ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P08908"}
{"id":"6c417836-33b2-46b3-ae20-42143123367e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:0c0c130b-04f6-4f41-a5b3-63be82df1726","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P35968"}
{"id":"ef931046-dc3c-461a-890a-3fc776b72c3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64217","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:1da29ebb-4faa-428e-abc4-ae499923daa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:983","original_object":"UniProtKB:P21917"}
{"id":"7f9dbded-692e-470f-bb06-83304917cdfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1017","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:f58e1c97-9312-420a-a130-199a711f5af2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1017","original_object":"UniProtKB:P21462"}
{"id":"6b7a14ad-0efe-45c8-ada7-6b9db5784398","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340686","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:e471a54e-3054-4f51-957d-8eab77c5755d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8058","original_object":"UniProtKB:P53779"}
{"id":"c91dc816-cdc2-44c2-bad1-220ee63de0d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:fad1f8f6-c2b1-43c6-8abd-29c392b59a8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4091","original_object":"UniProtKB:Q8NER1"}
{"id":"f035fa43-4b39-4744-9274-0ec93486b010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133797","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:8a2d0729-5b1f-4453-9911-fdb845351d68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2311","original_object":"UniProtKB:Q9H2S1"}
{"id":"9956778d-7f47-4366-9a2f-8f8530335512","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:74MLR03FLC","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:52b07318-bcc4-404e-9012-6cca3b46cc1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:63","original_object":"UniProtKB:P08908"}
{"id":"74dda78d-a933-4c63-ae83-62f92ee0f719","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47943","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:b49be435-91aa-4cd6-a8b9-a02602c216d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4133","original_object":"UniProtKB:P42261"}
{"id":"99a63489-4e4c-45e3-83ae-36ea3681e161","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZXM835LQ5E","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:d68dc648-e179-41a0-94e2-f89b08555ce2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7902","original_object":"UniProtKB:Q9Y243"}
{"id":"8a49f9cf-38f2-4774-90bb-a9b24707b1b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9911652","predicate":"biolink:affects","object":"NCBIGene:27148","sources":[{"id":"urn:uuid:3e218b2c-da1c-47b0-833c-2f22ca0ee7d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8203","original_object":"UniProtKB:Q9NRP7"}
{"id":"fb822d50-58c7-487d-ab51-2e408f0f3765","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"UniProtKB:A2ARP9","sources":[{"id":"urn:uuid:f3ceb019-c26a-4d15-bb8e-8ff7ec53d3c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:A2ARP9"}
{"id":"bc38f582-f733-4969-b972-2b91e3228a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7478","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:10359885-4788-4a27-abbf-e9a4f6c46aa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:45","original_object":"UniProtKB:P28566"}
{"id":"0ac7a2a5-549c-4329-a525-85168e6974b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31684","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:5fb06489-7114-45ca-8d57-489f7f9a46ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7399","original_object":"UniProtKB:Q07343"}
{"id":"0effdac4-87ef-4827-93af-d12eb6a20cd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233310","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:f27a2f69-d7b5-4fa5-8783-fc5f6061caac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6011","original_object":"UniProtKB:P04626"}
{"id":"d5269112-64f1-4f24-92bd-b6b8ef108234","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5398","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:b3cc6d3f-495f-443b-90c3-d502176f941c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5398","original_object":"UniProtKB:Q9HBX9"}
{"id":"d546d7b5-0450-47fc-964b-c62992d845f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4551","predicate":"biolink:affects","object":"NCBIGene:476","sources":[{"id":"urn:uuid:08ef6756-e985-4ea8-a2de-15211ccb9dab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4726","original_object":"UniProtKB:P05023"}
{"id":"7f6b6181-c245-440d-bddb-c0907ad05f7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32509","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:bdbe7441-e878-48eb-9020-d1a76a3cfdd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2666","original_object":"UniProtKB:Q07869"}
{"id":"659203a1-af96-4043-96a7-a3aaa88cc195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:7e02b197-4642-4672-80b1-afeca0a35291","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P05129"}
{"id":"eebfe9c9-6165-4bdb-b2a2-17e125ba5bb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:50d21f29-aa67-4e0b-a185-1e2a443c51d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P28223"}
{"id":"50b883ff-9446-43cf-9ecf-71a715aa50d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:79022098-80d7-4b20-a368-c7b9ec6b4d35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q13547"}
{"id":"19c0d869-99c6-4b26-8ffb-4ecd22c21058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54758482","predicate":"biolink:affects","object":"NCBIGene:9024","sources":[{"id":"urn:uuid:672694b8-3dcc-4ad5-bf00-8f86525c95d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8215","original_object":"UniProtKB:Q8IWQ3"}
{"id":"573e17fd-01aa-41f1-b051-8f1f6ffd1a05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4S4LA22APY","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:c5122369-ca3d-4811-95c7-bfc8207a6f4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2217","original_object":"UniProtKB:P37288"}
{"id":"ca573428-f158-41da-b5cf-29ce03ff2cea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139549388","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:b9b29ca7-4388-4925-aa21-d09607a499c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12873","original_object":"UniProtKB:P07333"}
{"id":"fecd7b59-50ca-4ece-850d-bcffeecb032c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600331","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:7956c89e-aadf-4746-8537-684276d82181","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10668","original_object":"UniProtKB:O14842"}
{"id":"85f411f7-d7f9-49f5-b5e2-5ca364d9e7ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817433","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:3a87d711-db68-4ec4-854d-cdb50f9ec067","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1827","original_object":"UniProtKB:P70555"}
{"id":"f77c5f31-628b-4d18-8802-ea0f34e944ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135574","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:3fd6cf84-14b5-45dd-9cd5-a44d2f0b3e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9071","original_object":"UniProtKB:P34972"}
{"id":"345959bf-642a-43d5-8602-5e8135b86cee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95087","predicate":"biolink:affects","object":"NCBIGene:54583","sources":[{"id":"urn:uuid:38293beb-e11e-4d31-bba3-1e0fc9a2ce46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8229","original_object":"UniProtKB:Q9GZT9"}
{"id":"e085556b-d21b-4f4e-a382-e392113dbdb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996542","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:2b9dd19e-d591-460f-9fb6-5a45df82623a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10706","original_object":"UniProtKB:P21589"}
{"id":"c27075c9-9fb8-4cf6-9f3d-8885ea3f2372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:44c25a37-0a55-47a4-9235-884c8b632559","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:P48542"}
{"id":"a876d221-71e7-47e3-b4f8-397432848c84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3561","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:330aa476-79c7-4648-b3ab-c3f2a547b385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1222","original_object":"UniProtKB:P35367"}
{"id":"5ebd6e45-b0c2-4c9f-8d56-7e7800f50d1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5P363AFVC","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:3a86202a-d1e2-4e74-8a8d-c9fec2e7511a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2638","original_object":"UniProtKB:P10828"}
{"id":"97350615-cac3-4bfe-9394-49e410466d9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4761298","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:67e8b1df-6672-494c-8194-7d908b56384c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11600","original_object":"UniProtKB:O95271"}
{"id":"299e204e-7684-429e-9fae-ae102b64823c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70735","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:584beb1a-dd56-471a-97cc-09fffb1cd83a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7461","original_object":"UniProtKB:P18825"}
{"id":"ed38224b-647c-480a-ad21-1a68dbda96a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90705","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:db3276bc-9b4e-4729-a8cf-6bf57f30cb3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5269","original_object":"UniProtKB:Q16539"}
{"id":"6d2ba1d7-8b2a-4b8f-bef1-77fbceec2882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:ab1c9201-3c98-48e7-9f9e-2a28292f1bfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:P31391"}
{"id":"605b0ca2-1dff-4ab5-aa76-1abc46109716","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4329839","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:bef3a4d1-797b-4c44-ad02-2c9de7bf8894","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:861","original_object":"UniProtKB:P30551"}
{"id":"ca7064bb-ac49-4113-b2b9-cca9bb4540bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2765033","predicate":"biolink:affects","object":"NCBIGene:5793","sources":[{"id":"urn:uuid:b0d8aa40-4093-4922-a1b9-9712a0e23b8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8831","original_object":"UniProtKB:P23470"}
{"id":"18fcd95e-771b-4e4d-9b4b-8a359c251de8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345320","predicate":"biolink:affects","object":"NCBIGene:1565","sources":[{"id":"urn:uuid:b9229ce7-e084-4733-aead-a3d664ccc9ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9882","original_object":"UniProtKB:P10635"}
{"id":"f6236fb2-3167-433a-9310-31318a21d3d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149519","predicate":"biolink:affects","object":"NCBIGene:55193","sources":[{"id":"urn:uuid:3a57fa64-3a80-49e4-9570-92240727280b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7915","original_object":"UniProtKB:Q86U86"}
{"id":"b6c8fbca-64c9-4358-b864-0f249ce7fa1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:96514065-ca08-45b2-96ae-bb977bd46a80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9P0L9"}
{"id":"58222e71-a1fc-4c55-8bcb-b4ac6a9f4ebd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z0O8PGE4TB","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:8cc6ee61-31dd-4b3d-81d2-598229a2c09c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9050","original_object":"UniProtKB:O00519"}
{"id":"d6df34d6-a446-4226-9633-34e833909521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:f0c36fbe-7f16-4766-b5f9-9b4d50a7c4be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P43119"}
{"id":"5972fc54-fd9d-434d-a03e-44cf985925af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755028","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:273c7989-fe06-44b9-8e2b-3ad7f64c2fa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2710","original_object":"UniProtKB:P37231"}
{"id":"fc444bb1-3ace-4ab4-93d8-58813f6f4b14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:50839","sources":[{"id":"urn:uuid:5ce4252e-60f3-4c44-92df-01b915e671d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:Q9NYW0"}
{"id":"31f6f014-ac0c-4d4e-9524-91d04c1e56bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:53bd0fc8-3bdc-4ae1-b06b-adf6bf563571","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q9H2S1"}
{"id":"b8545dbb-45eb-4e46-8af4-bf42903dc4ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1524","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:c3323104-e099-4d00-ad9c-97f09086922a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1524","original_object":"UniProtKB:P49146"}
{"id":"08dca694-916b-4b70-883d-64adfccc0897","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71041983","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:5ae85b14-c89b-4e03-a4e6-4bb9bc2edd77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6706","original_object":"UniProtKB:Q14833"}
{"id":"1dc4b7ba-9bec-4271-98dc-658b21073b5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR9ZYH80Z8","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:6c77b113-5940-480d-8551-77c634b7d68a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9787","original_object":"UniProtKB:P22455"}
{"id":"47050645-475f-499f-8400-6d4e78571131","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131152","predicate":"biolink:affects","object":"NCBIGene:23135","sources":[{"id":"urn:uuid:3d180c5f-d803-4157-9bee-4d422adb37bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7027","original_object":"UniProtKB:O15054"}
{"id":"640fbdc0-244e-4654-98b8-d056ea6a92cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91198","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:92e75b3c-be7f-4a6d-ada6-e4607ca25a02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6050","original_object":"UniProtKB:P36897"}
{"id":"effdcb90-cfc0-499d-9744-0d639a149007","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:4adf0882-7b82-404c-804b-236fbb2c2124","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P33534"}
{"id":"5f0a233d-580d-4975-8003-7a650b62833c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75984","predicate":"biolink:affects","object":"NCBIGene:3743","sources":[{"id":"urn:uuid:3e369fc5-e0b2-4f29-bd02-221f1f6dff78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2560","original_object":"UniProtKB:Q96RP8"}
{"id":"f6766bcb-4cd9-430b-aad1-f5be898d7973","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1505","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:51a0666a-f45b-4998-9dc0-f0517fc6ad81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1505","original_object":"UniProtKB:P49146"}
{"id":"cbb896ae-b675-481f-9a18-71d5001e9a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63451","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:643a9000-dbff-40ed-9b43-ca42b9454dfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7877","original_object":"UniProtKB:P35968"}
{"id":"10f50ab8-8547-4e50-950e-f00f43a695e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49490","predicate":"biolink:affects","object":"NCBIGene:5163","sources":[{"id":"urn:uuid:7e4de845-1186-4816-81fb-2e42468d4afd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9362","original_object":"UniProtKB:Q15118"}
{"id":"774a2e68-1a03-49f1-a0c6-db2a422ff60e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28130","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:870e56d8-4c04-4486-82e4-3c330b0ca391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1876","original_object":"UniProtKB:Q9Z2J6"}
{"id":"8c710722-0d61-429f-bf0c-7ad1d9385984","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95037","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:de99b852-b6d3-420b-aa79-813f53ad3005","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5244","original_object":"UniProtKB:O00519"}
{"id":"936b3e0d-3d18-40c8-bb8a-8ce0c058c68f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2001","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:cf617467-5867-4b91-a5ec-b69f86b5be6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2001","original_object":"UniProtKB:Q8TDU9"}
{"id":"475c2a49-36f6-4891-8f54-306db75c2647","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:a2a6394b-4be8-40f3-b2c3-424269502f5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P41595"}
{"id":"8374c6ce-a00d-45ec-81b9-f7e30681d108","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:89332a7d-7dd1-4976-b59c-2e0675901b44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P28223"}
{"id":"fe7ac27e-1304-49d3-85ad-52fb93b74095","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:4d8ce54f-7fec-445f-ba6d-f6999ebb7120","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P47869"}
{"id":"2fa9208f-8439-449b-9564-68c6c97a49ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135489238","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:d719b025-3f74-420d-a97e-062fe7dd8608","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:381","original_object":"UniProtKB:P29275"}
{"id":"5250f0e4-9418-40a4-8250-faddd29999bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3P4CR02JTD","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:a0fae8b8-d290-41bc-8234-6150dc688096","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11714","original_object":"UniProtKB:Q16539"}
{"id":"ac63398b-79a8-4b91-9d90-9427b0bf99b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92918","predicate":"biolink:affects","object":"NCBIGene:84254","sources":[{"id":"urn:uuid:e6f21b66-4e7e-4b62-9d75-33f8555324da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5274","original_object":"UniProtKB:Q8N5S9"}
{"id":"cf5a6e1d-247b-4aeb-863f-47878107248d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SPI5PBF81S","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:38c02044-eed0-40f9-9993-c5859be24a0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7858","original_object":"UniProtKB:P08473"}
{"id":"6901ddc5-74b4-41bc-8c92-7612a568aa4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:8fe56a4e-f6b0-4ce3-8abb-b92c72f4f8e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:Q62805"}
{"id":"9c559c36-c1de-4d64-93cb-a6538cd034ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3649","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:3b4c418f-c58d-4a4b-b002-adfeb0132af6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3649","original_object":"UniProtKB:P51677"}
{"id":"19505582-3148-4df3-b8b9-cc93e2e3fa78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2565","sources":[{"id":"urn:uuid:a522715d-ea17-4d77-a97a-5fd29a16dc3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:Q8N1C3"}
{"id":"acc8c65f-f732-45b4-bf9c-e2635409aef7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16109435","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:557dd0a8-b91f-41e1-84bf-765f1af9f36c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5607","original_object":"UniProtKB:P29275"}
{"id":"4c07aee9-18ad-4336-a61a-b9f164abb36c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4284209","predicate":"biolink:affects","object":"NCBIGene:57396","sources":[{"id":"urn:uuid:57c9027b-1ea0-4a56-99b6-876042b28c6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10081","original_object":"UniProtKB:Q9HAZ1"}
{"id":"3b7d22d8-799f-4a51-9ebd-c6cb04f630eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:01J7526K2Q","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:a5cf9ac2-e95a-4000-939f-c71a02030108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9569","original_object":"UniProtKB:Q99500"}
{"id":"56df9e8a-010f-4768-8b32-178b94989097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95061","predicate":"biolink:affects","object":"NCBIGene:83903","sources":[{"id":"urn:uuid:4e4c1998-908f-41fa-819e-98be4ba5827a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8784","original_object":"UniProtKB:Q8TF76"}
{"id":"7210b933-99b7-4822-bc0b-458999cba287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72163809","predicate":"biolink:affects","object":"NCBIGene:8444","sources":[{"id":"urn:uuid:5be170d4-8499-4c98-8bad-26cb7910fef1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8128","original_object":"UniProtKB:O43781"}
{"id":"dc2755cd-f6f6-490f-85d4-e07686e4cf6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996528","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:80476934-517e-4ce5-871f-95d9df68ae44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10603","original_object":"UniProtKB:P35408"}
{"id":"58bfcccd-2822-4877-a6bf-a258aeebb17f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91376","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:80297be9-b948-4c15-b68d-99d20479ada3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8353","original_object":"UniProtKB:Q96GD4"}
{"id":"42caf227-1d9c-4bac-b6eb-83d0684e69e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44595851","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:3abe6117-bd23-4b05-90d7-d3ae98563bf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6259","original_object":"UniProtKB:Q14416"}
{"id":"9654561a-a8fc-4a68-9ce9-fd2ab9d0e519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:2394886d-bd7f-40f3-87bd-e42a6fbecd4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P21918"}
{"id":"301a20a1-6796-410e-a766-503baf237318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11436","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:cfb4093b-8548-4af8-abf3-9870110f5f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11436","original_object":"UniProtKB:P30411"}
{"id":"bb89d7b8-bd4b-4832-81da-0b78fa563209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:008f4e6c-68cb-4786-9076-97038bfaacfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P30542"}
{"id":"aa8bcae4-cdcb-492a-b3f2-e5d5f5575bfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755156","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:b14c4008-912d-489b-8228-9aea67acaaa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5794","original_object":"UniProtKB:Q8TDS4"}
{"id":"f7e97def-b0cd-454a-9136-2a41c0a5f81b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:567d2ea6-92b1-476f-95c2-6e1f204b6d9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:Q00534"}
{"id":"52340cf3-7bae-4c36-92fd-ad6593af911c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1778842","predicate":"biolink:affects","object":"NCBIGene:247","sources":[{"id":"urn:uuid:7b06a0dd-72d8-4fcb-a658-04d8d137d47b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10264","original_object":"UniProtKB:O15296"}
{"id":"15901d33-009a-4956-86f8-8cb3a5fb5166","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:6a7db4e4-4dce-4111-a705-f608a9739e50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:P52333"}
{"id":"bf0a59ff-2990-4d62-a570-4e7f5fac4a69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K41YC3AEI8","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:24b64e49-4043-4432-a116-bef61061177f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1622","original_object":"UniProtKB:P35372"}
{"id":"eab79662-08c2-4ed9-b0f0-135ea40e695c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177440","predicate":"biolink:affects","object":"NCBIGene:24613","sources":[{"id":"urn:uuid:d97bfd90-6f24-4460-9cb2-139b20f99196","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1640","original_object":"UniProtKB:P33533"}
{"id":"eafc1405-f640-47e5-887d-617107c389c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:65095159-a30f-46f8-9f65-cbdc8fb27f51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P21917"}
{"id":"04e95f72-f005-4271-846a-4aeb891cc2af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BLP1XA3FZA","predicate":"biolink:affects","object":"NCBIGene:7357","sources":[{"id":"urn:uuid:f04a1f59-1bd9-4dc8-bea0-d596f49e2514","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11550","original_object":"UniProtKB:Q16739"}
{"id":"3c198177-1a1c-48fc-ab45-b6f683c31c3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZK5NA2M82J","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:3298c208-2f58-444d-a5cb-460c45a44412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4299","original_object":"UniProtKB:P31644"}
{"id":"7c8f5fc3-4314-4137-8e7b-7f302543cbad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:1885a5c3-9868-4a5a-890a-64066bd252f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:O08858"}
{"id":"01ee11af-506f-490c-b242-2e0a15ff031b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49843739","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:d0e7c9a7-f87c-4246-b994-106a9e8bcfd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8867","original_object":"UniProtKB:P41146"}
{"id":"9c7fa729-c853-4bfe-94d5-e3bfc4f78c80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25025654","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:22d692bb-7a50-4009-847e-99f3449e8aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6189","original_object":"UniProtKB:P32247"}
{"id":"b65fc575-12b6-4992-b29c-7406ca3b23de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ZO554A4Q8","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:1e4a81ef-3b67-49c1-8789-e9747126a522","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10559","original_object":"UniProtKB:P08684"}
{"id":"1c72bc3f-b802-49b2-b6ba-7d8a25e68d46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52172","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:239dab11-c975-4e13-8e24-2f6941b728f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5697","original_object":"UniProtKB:Q08345"}
{"id":"fb32ba42-8523-4b93-bbdd-4b63cd298725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135332280","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:bd8e8a85-ced2-4b8d-aace-b5ca7bb7acbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13512","original_object":"UniProtKB:Q15910"}
{"id":"fefb8917-eb87-4acd-ba25-646de8ee9cd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11757797","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:401b3fd1-2051-4bb6-b4e9-9f09c02cb3d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:292","original_object":"UniProtKB:P11229"}
{"id":"3393d825-29d3-42c9-a8bd-111c3f9007f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134990","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:69dd08b4-df83-4996-b730-c6e665614ed9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:198","original_object":"UniProtKB:P48039"}
{"id":"25a04a67-eec4-4f6a-97e3-98fdccbdbcea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:cb5a4ca3-0595-4c15-bb9f-4922b5d75cfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P17948"}
{"id":"d223fe46-f740-47b0-95cd-9e80e137565a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4909","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:63ecca8d-4979-4255-97f8-762c85abc590","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7185","original_object":"UniProtKB:P35354"}
{"id":"2f8f2f95-43d5-4851-b5de-ac6b3bb7ae0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28852","predicate":"biolink:affects","object":"NCBIGene:117155","sources":[{"id":"urn:uuid:7444d74a-fe9e-49a6-b30e-b17cf84104ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5412","original_object":"UniProtKB:Q96P56"}
{"id":"c30e4e20-785e-46c2-ba57-630e3f86c1cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:678","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:7692165e-92b4-4b75-be68-17e4c9ebd78a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:678","original_object":"UniProtKB:P30411"}
{"id":"d87fe0d6-ae24-4b84-a146-d043ebc72deb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3885","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:3c4bff33-f6ce-40c1-ba74-364a502bb5e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3885","original_object":"UniProtKB:Q8WXD0"}
{"id":"23507a6b-c616-4237-8c71-8fa8f9427e2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67547","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:0301f7fb-a8bd-4037-97f4-8ccde6ffe048","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13469","original_object":"UniProtKB:Q08499"}
{"id":"05b5e0e7-6fd1-43da-9cea-ff815f4c7338","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0W79NDQ608","predicate":"biolink:affects","object":"NCBIGene:11330","sources":[{"id":"urn:uuid:210e2e22-2a33-4611-a020-456d3102a858","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11754","original_object":"UniProtKB:Q99895"}
{"id":"3c82593c-476f-44aa-8cac-52d1d2c4940e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:d363a4e1-6a07-4cfe-9c28-38eaadd3faa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11859","original_object":"UniProtKB:Q12791"}
{"id":"b2061ca6-4166-45bb-a6fe-42f84c59354a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:c61bc85f-0413-45c8-8201-5a9e0b651f94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:Q92633"}
{"id":"595bcc01-3015-4292-a35b-4d237db3a581","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5628","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:616cc5c7-c915-4eb2-8d3d-4713888c8bab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5628","original_object":"UniProtKB:P30874"}
{"id":"105d5c7d-b720-4263-9c40-ea9a44c1f70f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2040","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:a3bc450f-19d2-4ab4-a7e7-22a713129162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2040","original_object":"UniProtKB:P30935"}
{"id":"12f110b2-267d-443c-b127-6af941daf06f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2622","predicate":"biolink:affects","object":"NCBIGene:259293","sources":[{"id":"urn:uuid:11bb553b-e599-4031-9ecc-840cef288f97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12459","original_object":"UniProtKB:P59541"}
{"id":"fbc44f2d-aeed-4620-8d27-0b6b2864fb0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:72W09924WP","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:53482d1e-aabb-4f64-be22-9126aacbd4a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2883","original_object":"UniProtKB:P06401"}
{"id":"1d1b14cd-6d74-4e9e-99b0-3ff75dddde09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:5852c105-ba20-4a8d-bd10-bfcd6eaa78cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q12809"}
{"id":"b97f4a26-c5a5-4fb0-b012-7baa542b98b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156273389","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:c1bd30f1-1419-4a1e-a75c-d729a1bf0b81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12313","original_object":"UniProtKB:P21802"}
{"id":"4883a6c1-f008-44e5-8aa2-9d43dde14890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:72f996fa-4e49-43c3-83ad-5d70214518cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P11229"}
{"id":"c67028cc-beae-4d98-aa68-f9a171de9e42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149226","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:c8b5d758-6647-4b06-90f2-f7f26d9943ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:557","original_object":"UniProtKB:P08588"}
{"id":"d4de09eb-2065-4533-95dc-78225b4cee7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3N422P20J8","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:c7718a6d-3c0b-4e2a-9b1a-67311ff77273","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4368","original_object":"UniProtKB:P14867"}
{"id":"db2c7091-0c45-4a32-b067-e901a6dde3c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947004","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:94b79d82-86fb-483a-90af-2df8dc789f74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3135","original_object":"UniProtKB:P37268"}
{"id":"59500c27-60fd-41f7-8f18-238e20b1d8d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91340","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:33a7ca74-f1c4-4aac-bc4b-238cb3cfc2e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5669","original_object":"UniProtKB:O14920"}
{"id":"0fec7be3-3e75-4f40-b44f-cae716f805bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"UniProtKB:P30940","sources":[{"id":"urn:uuid:c26e01e3-f2f9-484a-bdea-cbb8c6f1ce1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P30940"}
{"id":"1e297ce9-10a1-4354-9fce-aef64eeb775a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:446738","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:3083d7a8-8f6f-4122-bd34-c47f9069a489","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3440","original_object":"UniProtKB:Q07869"}
{"id":"04e8d129-1016-49f1-b08d-becf29abe8f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75W6I8W6OU","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:b3a9040f-8c74-4247-8d92-66ea84df10ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4249","original_object":"UniProtKB:P48058"}
{"id":"10a45ffd-4636-4bea-820f-c81f695b6351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34725","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:488781b4-31fd-4baa-a9fc-1d3f5f105302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2403","original_object":"UniProtKB:Q14957"}
{"id":"48c8cd27-a030-4018-b15e-6fdd2052fd9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3657","predicate":"biolink:affects","object":"NCBIGene:10803","sources":[{"id":"urn:uuid:1f5b6994-f33c-46d4-9ad6-42b9973b2dac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3657","original_object":"UniProtKB:P51686"}
{"id":"585b92ea-c99b-436e-ab9a-1c3382ce1dbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:14D65TV20J","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:a1f3a046-e44b-4ec4-87a9-4f23dad76db5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8863","original_object":"UniProtKB:P30530"}
{"id":"1dad2f4f-3351-4948-b87f-9a605f2cce6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YET2XNU791","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:3a9dae37-7d77-47b0-b538-c9c058ada1d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10461","original_object":"UniProtKB:P50750"}
{"id":"cbb0cba2-d45f-47c5-9125-830cdced26e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3216","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:1168e4b6-f7e7-4f1c-9558-2a40b420ab95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1670","original_object":"UniProtKB:P35372"}
{"id":"544fc352-107c-4a03-868b-840637ab340b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73389638","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:d5e14c59-a91e-4cfe-aa1a-f06623191e67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9761","original_object":"UniProtKB:Q15303"}
{"id":"afc87267-c4c3-473a-8c5e-d5a77e963491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231352","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:a63e43a2-c58f-421d-a072-f6bd7c086f27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7502","original_object":"UniProtKB:O15379"}
{"id":"a035243a-66ae-4954-bc47-fef416db3f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3082","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:3fdde232-4c0b-45f8-9c83-240805fbcfa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:549","original_object":"UniProtKB:P07550"}
{"id":"298cd504-280c-4aaa-b857-7ece432cb4ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31205","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:80f11bc7-2883-4f46-a34f-e51d47ca921d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7113","original_object":"UniProtKB:Q9UHD2"}
{"id":"31d993b4-0794-4e9f-a55d-d396bb254ba3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:152031485","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:6671a257-07b7-4c99-833f-b199a4275f97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13008","original_object":"UniProtKB:Q96P20"}
{"id":"aac26a0d-403a-4798-ab6b-36ee80b74b7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1116","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:6fe6f18d-88a4-4ab2-a41e-19fb88930241","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1116","original_object":"UniProtKB:Q02644"}
{"id":"6b203d2b-652f-415c-a56d-7ce8ca3c135f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755254","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:9bc6adb3-8721-415d-bba2-345bc0605e2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6992","original_object":"UniProtKB:P21453"}
{"id":"ac964ce7-23f2-4684-9fc0-36c515bab9a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431314","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:e57278a0-36e6-4705-8c37-d8129ac1e896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11288","original_object":"UniProtKB:P14416"}
{"id":"56f8970d-8f23-4c40-9724-9104f595b5d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9L2885WUL","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:e76d883a-6e05-4b47-b7cb-eeb131e75642","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9299","original_object":"UniProtKB:Q06187"}
{"id":"aa4e9a09-27a3-4c8e-b4bd-11f83fbe49ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:a9d7228a-2a77-44a2-96a8-9d807a34855c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P50406"}
{"id":"564a42a6-3d88-443c-a65e-d17355cd4495","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:3910bad6-c5e9-46f9-bb73-46b6553a11ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P28647"}
{"id":"9ea53e39-3e16-4a93-a234-c036ec5c53d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15713","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:3c641955-f764-4e50-87aa-673415f23bd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1734","original_object":"UniProtKB:O35811"}
{"id":"b820d526-d585-4f5b-a851-f3dc01766bc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17552","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:82b5ce9a-b5dc-430f-8720-9e5e6fb2d88f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2410","original_object":"UniProtKB:P97794"}
{"id":"3917d7a8-f893-4ba6-83b8-91e56f508423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:78XZC39FR5","predicate":"biolink:affects","object":"NCBIGene:3422","sources":[{"id":"urn:uuid:4eb4c546-2848-43f7-80b1-0c16d16d7b1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3167","original_object":"UniProtKB:Q13907"}
{"id":"0290d2c8-138d-4412-a478-0bc5f0fb8785","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11530404","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:53da5037-cf54-4bd1-b691-a17f74432dc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6211","original_object":"UniProtKB:Q13255"}
{"id":"0373673f-57bc-4d11-a95d-6b35c463be57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4659","predicate":"biolink:affects","object":"NCBIGene:29539","sources":[{"id":"urn:uuid:bd7ba121-770c-4546-8e9e-2fb4abff7c23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7168","original_object":"UniProtKB:P11884"}
{"id":"84a6e4c6-0b77-41f2-b7a8-02a24cdfb51d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817500","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:2b099902-84cb-4021-9893-174b227ea22d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7041","original_object":"UniProtKB:P04201"}
{"id":"4f9616ce-709f-46f4-9f7c-6ca70c71fe99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:12777","predicate":"biolink:affects","object":"NCBIGene:7182","sources":[{"id":"urn:uuid:fd57d261-0211-4500-b4a4-7eec632c56ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4053","original_object":"UniProtKB:P49116"}
{"id":"28a8e725-3013-4000-b1ce-6b6bac247a33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15626","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:f6175d1d-09c8-47fd-b757-9d508734fa8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2481","original_object":"UniProtKB:O35433"}
{"id":"43174937-0b96-45b0-8c23-21b2d39037cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755226","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:d7081a57-21dc-47a2-a71e-feae2837bbe4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6579","original_object":"UniProtKB:Q9HBW0"}
{"id":"bd74aa3b-8ae9-4474-b5e3-51b4f997ae01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:46de9e94-ee73-472f-a485-01088cf5b6bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2486","original_object":"UniProtKB:Q17ST2"}
{"id":"80d868ea-2a74-4cf0-88b5-94b364cddf56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:291342","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:4119bca7-7642-40d1-bb0a-5557260edb31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7157","original_object":"UniProtKB:P35367"}
{"id":"8c40dfee-d49f-494f-be42-2e6de053805b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56843330","predicate":"biolink:affects","object":"NCBIGene:5328","sources":[{"id":"urn:uuid:4281d2c0-4e32-423d-88be-4a79f1ef9669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6497","original_object":"UniProtKB:P00749"}
{"id":"085de618-c395-426c-9844-74f5cfe78910","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11921","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:ea61ee69-b819-4ef2-ace5-4e800be97fda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11921","original_object":"UniProtKB:P0DTC2"}
{"id":"ead605b0-2691-439f-a83f-bc25a9042660","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868176","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:3366b6a8-f46f-4895-8ad4-1c5e87ff5f1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3800","original_object":"UniProtKB:P50391"}
{"id":"9e19fd73-4013-4db3-b929-82d18bb4894b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132427688","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:584fafd4-90e3-4763-8503-c54f4cfc8d61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9810","original_object":"UniProtKB:P22303"}
{"id":"2d9cf605-5131-4d54-bbfa-6bb3e25a5ced","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35003","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:56b19912-62f5-414f-af68-2c984b49170f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4068","original_object":"UniProtKB:Q12879"}
{"id":"570ad17b-dff4-4634-bd5b-90f483395931","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755064","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:3da413da-2033-45cd-8fca-19dd9400c728","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3971","original_object":"UniProtKB:P36544"}
{"id":"486b41e4-61c0-4f13-a810-79945bec7ed6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925685","predicate":"biolink:affects","object":"NCBIGene:27330","sources":[{"id":"urn:uuid:7444fafb-29d2-42f4-a7bf-6ea336a9d744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10597","original_object":"UniProtKB:Q9UK32"}
{"id":"10d20118-a830-4ecb-9236-8fa2fe71d267","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:8021a790-4cad-4b8e-a48b-4d67099f0ff8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:P30874"}
{"id":"dcae9d92-13ec-49b2-84fb-7e1e7bdf1f51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6121","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:7d797827-7c95-411c-a4ce-603f0bb36c98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4233","original_object":"UniProtKB:Q12879"}
{"id":"d9124e21-a0ac-41e9-a979-ba084a6b2b1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:a851105c-72d2-4920-83ed-381a375c7bc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P28335"}
{"id":"0ce942a8-da58-4604-bb5b-322d675d8886","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311198","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:129da551-6bf5-4338-b26f-a791769304ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1359","original_object":"UniProtKB:P49286"}
{"id":"66bd3f92-5f10-4293-bbab-ab2790412a2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10033","predicate":"biolink:affects","object":"NCBIGene:79001","sources":[{"id":"urn:uuid:4950a25f-c0e1-43c6-ae6c-42f4a89be441","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6853","original_object":"UniProtKB:Q9BQB6"}
{"id":"a68e8380-f8a5-45f0-8a2b-733adfe76b11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11650194","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:553572df-99c5-458b-81b7-9e9767a51613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8292","original_object":"UniProtKB:P08581"}
{"id":"de8f9b83-a335-4952-bda2-ddba3bcba61c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QWK86805EB","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:4feedb62-06de-4eb5-8bcf-9bc31ad34637","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:352","original_object":"UniProtKB:P10980"}
{"id":"86f5007b-7ab5-4f4e-93e2-4f08e31afc52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8499","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:becadea4-cf7f-4505-9f2b-4ddf41d3336d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:564","original_object":"UniProtKB:P07550"}
{"id":"befd0db2-fd69-479b-bcea-96552f0b33cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1577","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:baa3e808-a235-4a0a-8df8-39bbee432283","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1577","original_object":"UniProtKB:P30989"}
{"id":"5eea4b64-b13c-4ec0-bb64-e3894a076184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:e3ee6c83-3926-432d-8a2b-1e786b25038c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:P30530"}
{"id":"79f014b5-f95f-4dac-b3cd-d3c25c930562","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9598","predicate":"biolink:affects","object":"NCBIGene:3683","sources":[{"id":"urn:uuid:22776975-6986-4fd0-9237-a35c5c652a5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9598","original_object":"UniProtKB:P20701"}
{"id":"42b11525-4372-4695-afa7-937c821f35af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86704319","predicate":"biolink:affects","object":"NCBIGene:1075","sources":[{"id":"urn:uuid:e84e7317-390a-4e43-8a24-8aef3cffca5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13960","original_object":"UniProtKB:P53634"}
{"id":"d8a0645e-f6b8-4ddd-9647-5a59a2dc945d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GKF8S4C432","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:638b5a8b-1fc2-4ab5-90d3-de20a0535974","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9601","original_object":"UniProtKB:P11362"}
{"id":"baf97627-58fc-46ab-a61d-5536fb262ae9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QS8G2Y8E0","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:59beaf55-aa2f-4e48-bc80-7ab95b82d1e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7687","original_object":"UniProtKB:Q16539"}
{"id":"3fc17311-432e-45b4-aa03-1039066808a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:7a9d08d4-30d5-4a54-9ba1-1093be2f5ca5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:P05771"}
{"id":"2c37f60e-7fb2-400b-bf3c-098b7ba01130","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9070","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:8fb2a22a-b3cb-4dc5-8dc4-842fe30b947a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9070","original_object":"UniProtKB:P16066"}
{"id":"34c84982-4ead-479f-9f3a-ce43deb9161b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1815","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:655c63b9-e4db-49c9-abbc-5c9df330b660","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1815","original_object":"UniProtKB:Q03431"}
{"id":"cce1cc1a-163f-40c0-ba8f-15440c7d36c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3W2X0WGW6C","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:55cfe30d-6c0e-43e2-bb8f-c280b339a3ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5655","original_object":"UniProtKB:O95835"}
{"id":"c5bc0e88-8dbc-4aca-87ed-cb4c3722a4fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X60608B091","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:00c3f7f6-ac5b-4584-8e44-9f6bc96a1e35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10378","original_object":"UniProtKB:P34998"}
{"id":"60052453-9544-4b4a-af16-9097fffb0815","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:772","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:a15f099c-f08d-4f9e-b329-3ea9c1cdda9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:772","original_object":"UniProtKB:P51681"}
{"id":"24f51835-f635-49ff-b694-85c8b8e6fc95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67CKV7X08G","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:d96e0f0a-d44e-4756-a20f-03e2f3065c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5615","original_object":"UniProtKB:P29275"}
{"id":"61005a9e-306b-4ebe-82ef-9b14fc86cfbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167638","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:3662c2da-802d-4c1d-a9fb-cd20049f30eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7207","original_object":"UniProtKB:P08588"}
{"id":"ed69397a-7815-49af-ab97-039a2bf0b0f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9148","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:5c981549-db03-4ac4-8154-f465f0a51b7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9148","original_object":"UniProtKB:O14842"}
{"id":"aed6cd5b-a375-49cc-90b6-7b14fdc5d49d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22146595","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:dbd9f37f-ca01-4079-a298-e5d5bec81e35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:618","original_object":"UniProtKB:P28336"}
{"id":"7b9c9b51-01bd-4333-9f43-e91232023760","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1023","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:06104939-50fa-464e-8c72-998d7d12f763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1023","original_object":"UniProtKB:P25090"}
{"id":"fef0ea7e-9753-450c-bcbe-d702238b0b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10981286","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:3c2d32d3-c745-4995-913a-595cd9de8fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5599","original_object":"UniProtKB:P0DMS8"}
{"id":"c165939b-0875-4e5c-9288-deca56ba0f0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5632","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:cfdfd157-187e-4d4d-abe3-50e02476b067","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5632","original_object":"UniProtKB:P30874"}
{"id":"bfc4e2fb-dec4-4efc-9071-2f0a84a19848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4160662","predicate":"biolink:affects","object":"NCBIGene:51755","sources":[{"id":"urn:uuid:742d257d-162a-43cb-8679-6c203f0becc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10063","original_object":"UniProtKB:Q9NYV4"}
{"id":"e9aea0ce-6343-440e-a36e-3b11a5f3b11b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109530","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:64e15ee0-a9dc-4bd9-956e-0955fe1a5faa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4331","original_object":"UniProtKB:Q9WTR1"}
{"id":"5367c5c7-ee01-460e-98f9-c17bd431d592","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AIQ4OWD0RA","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:23f1baf4-c52b-4919-93e7-509cac768ef0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8527","original_object":"UniProtKB:O00329"}
{"id":"33d1a4da-81d3-4e85-964c-74ecbf8ee153","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SIS5BFO4WL","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:14709b67-63a6-462b-a807-4a28fab85b23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8427","original_object":"UniProtKB:Q13639"}
{"id":"36485903-9e43-44d7-9b2a-cff0a7c6ada6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135197617","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:629e56a8-39bc-4513-a71a-335f3ac5225c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10441","original_object":"UniProtKB:O00329"}
{"id":"01e84fb0-7714-4c31-a012-ba39d16cc3c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:6c728ede-d1ed-4a1b-b5eb-3df0fc6bb86a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:P06493"}
{"id":"c3251d4d-58d2-46fe-9f1d-54506cf00d93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:87TI61875H","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:71ac74f6-cc3b-4894-b528-06358613b3ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1069","original_object":"UniProtKB:Q9Z0U4"}
{"id":"ed708085-7139-46a3-8899-5e55bd130e4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155326246","predicate":"biolink:affects","object":"NCBIGene:8569","sources":[{"id":"urn:uuid:5a3a0296-577d-4314-8196-112d97a20fc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13310","original_object":"UniProtKB:Q9BUB5"}
{"id":"54e36d17-bf05-4a86-83fa-59f453a40ed2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49662","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:b38ec682-00ff-43af-a476-5a5d502ad8bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1909","original_object":"UniProtKB:Q9Z2J6"}
{"id":"38b200f0-c87f-4570-90b0-cc59e77fc764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:a949dbf1-91d2-4dc1-9897-dbd5e3958b42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P30935"}
{"id":"10c8dd2c-52aa-4633-89ef-c1d7a84d3453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:180ed0d9-0bed-415a-9e74-2f929c0b201c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:O88626"}
{"id":"87f060e8-71e1-40e5-b1f3-52abea3e7977","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7602","predicate":"biolink:affects","object":"NCBIGene:9429","sources":[{"id":"urn:uuid:3d0465e9-d1dc-41fc-a48e-ed36c63f849c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12446","original_object":"UniProtKB:Q9UNQ0"}
{"id":"f395362b-ad32-4a30-9bca-d529b83581d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15A52GPT8T","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:eed56d38-2c10-4b3d-ad20-7d1e1e970d71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7423","original_object":"UniProtKB:P06213"}
{"id":"041edeef-597b-4843-842b-33cd6799684a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:bb6bc6ab-56a9-409d-bc8c-325fd5e78345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P56373"}
{"id":"e91b35fa-9439-4069-ac92-917631be6b87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167638","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:2584a613-d866-413c-b8c2-c7e9f3821cd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7207","original_object":"UniProtKB:P25100"}
{"id":"b733b6da-dd98-4eb9-a06f-ebf81e19de0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:2faa9375-0c1d-45a0-9e97-92a4f15f3ca4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:P48050"}
{"id":"009faf20-95dc-4fb3-9be7-161b96e53a78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10428383","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:5b3fe203-bf4f-4de7-9f54-03d291ab98c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7783","original_object":"UniProtKB:P49286"}
{"id":"3f36f3bb-a1b6-4757-a505-87dd1e0f59e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:78a7badb-b0d9-4f47-adf7-764a9b4e007c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P43117"}
{"id":"f3ee6744-7adf-49db-8024-326a96afc146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16236","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:2c10c170-f49c-4edc-a0a4-7fc4836def3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2299","original_object":"UniProtKB:P23979"}
{"id":"d90e018b-0586-4f85-ba8f-1aa49f17fd92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:64800a59-f2b4-4883-8e30-e1de7db81aab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q08345"}
{"id":"94be1bfc-ff6c-4f3a-bad8-533e0c8d34f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125406","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:5d1dc3de-42aa-478f-bd6d-cc377770a7ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:132","original_object":"UniProtKB:P28334"}
{"id":"7c4503b3-8f7a-49d9-a9c7-3d0993226770","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137501999","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:1cd3e6d5-e18a-4468-9925-a0664af0a691","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10557","original_object":"UniProtKB:P35414"}
{"id":"da1cf87a-706f-4407-9246-811760251326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131168","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:112d03b2-2ba6-44d5-9a9f-592a77af41cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7890","original_object":"UniProtKB:Q9Y243"}
{"id":"12e3525a-fc28-4493-bfee-2d73cd62e255","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LG47VG1ID","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:8adc695f-597c-47ad-a2de-ad5fc2751ad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:380","original_object":"UniProtKB:P29274"}
{"id":"913aed7d-7815-467e-a475-e0a52e1b3525","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:612","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:5450cfa2-bcb6-4816-9d4a-49809015e3f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:612","original_object":"UniProtKB:P24053"}
{"id":"e7278ea0-9abc-4f21-b4e1-eaf193806816","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44343301","predicate":"biolink:affects","object":"NCBIGene:1512","sources":[{"id":"urn:uuid:334cec73-0b31-452f-be1e-190f55968d4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8613","original_object":"UniProtKB:P09668"}
{"id":"8a3d32ee-1398-46b4-bd72-70c4e0a48b9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137449472","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:a8b5b7e4-52ec-4378-be59-2a1a3f0a50bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10566","original_object":"UniProtKB:P03372"}
{"id":"a66fc10f-d0a9-46bb-8058-e329d1a4c7e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LDR3USH1NJ","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:2f965ee2-6db7-46f5-8ff3-f2657a5e4ecb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5612","original_object":"UniProtKB:P0DMS8"}
{"id":"e75012c5-13b0-43e2-9c0f-94fb4118a5ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92223","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:6cfa3372-dd36-4218-949d-ede2d10e2073","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8366","original_object":"UniProtKB:O15379"}
{"id":"0a6f9a42-3287-41ac-9988-3288bc0a1180","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183905","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:4dfe8168-2b03-4966-9913-bbf3be42c747","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3954","original_object":"UniProtKB:Q14416"}
{"id":"f9d012cb-f6f4-47a8-867e-bd77f4e025cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3920","predicate":"biolink:affects","object":"NCBIGene:7253","sources":[{"id":"urn:uuid:b77be720-9554-486d-9eed-c87f5c0f1011","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3920","original_object":"UniProtKB:P16473"}
{"id":"59e28488-7dba-49d1-be6a-004915e10222","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50938551","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:046d7ac4-b1bd-47e5-b944-1dbaee8ae659","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7854","original_object":"UniProtKB:P56817"}
{"id":"6433375f-7118-4260-b7d8-0eba2aaced07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:16ZDH50O1U","predicate":"biolink:affects","object":"NCBIGene:5595","sources":[{"id":"urn:uuid:1965f9e6-8b46-4b1c-b60b-93fe42ea685c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9210","original_object":"UniProtKB:P27361"}
{"id":"04c919e0-b8c8-43c0-93de-ece848c5da40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3665","predicate":"biolink:affects","object":"NCBIGene:310327","sources":[{"id":"urn:uuid:6978f4e6-95d5-452e-ad86-c25e8f88172d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3665","original_object":"UniProtKB:P83858"}
{"id":"5df9b009-eb4f-443a-89ca-d719950c6fee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94355","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:c564a6f6-b961-4cc2-b862-0c8b494478bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8311","original_object":"UniProtKB:P19099"}
{"id":"3c0a21cf-f5de-4016-a197-64b241b68c76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2W150K0UUC","predicate":"biolink:affects","object":"NCBIGene:6555","sources":[{"id":"urn:uuid:98926b5b-af4a-4934-93a1-1eeea002105f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11194","original_object":"UniProtKB:Q12908"}
{"id":"931631ef-ebd6-4f9a-993d-22a82cc19905","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132947","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:8f0ebf22-68bd-4b26-9613-ceec5ffe8a34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:361","original_object":"UniProtKB:P11229"}
{"id":"dd902704-89d0-41bc-a4a8-5a18f2d3028c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6442223","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:2bfd0256-2ea8-405a-bfb3-4d61ec71748c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2814","original_object":"UniProtKB:P19793"}
{"id":"7d2ff7f7-6fcd-400b-b5c4-e467e4a06b47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:af097943-4763-4a84-ab97-9c12718bfb52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2514","original_object":"UniProtKB:Q17ST2"}
{"id":"25b836b8-5f4d-4816-be92-dc4b9c54b299","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:127342","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:acb3bd36-328e-4e08-b2a9-3c9df967c5a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7118","original_object":"UniProtKB:Q01959"}
{"id":"9007c44d-c9b4-4f67-80dc-413cb83c11a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:e798e348-36bc-430f-b991-72f328018944","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:Q6RI86"}
{"id":"d1095a26-c955-48b5-a355-f7724f4c8c99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:29571","sources":[{"id":"urn:uuid:7584fcad-280c-4d2f-b1d7-6ac4d6700988","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:Q62968"}
{"id":"bd330908-ae42-482c-b675-afe5b75698dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:acdfb0a5-58b1-45ee-a5cc-54a33532ffa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P41595"}
{"id":"fdf216d7-40fe-4f46-a4c9-2eaf35feb0a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10371065","predicate":"biolink:affects","object":"NCBIGene:2288","sources":[{"id":"urn:uuid:3ddd8ab6-1534-4102-82d8-49f128e8826b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11480","original_object":"UniProtKB:Q02790"}
{"id":"faca3410-8dc0-4f76-a2af-912d04810606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71258526","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:9a012d2e-9d77-4ae4-b5be-916d1335df60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10419","original_object":"UniProtKB:O43353"}
{"id":"11603b7d-eec1-4879-a723-65b5c6c463e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121362450","predicate":"biolink:affects","object":"NCBIGene:7173","sources":[{"id":"urn:uuid:4fee6451-2bed-47dd-8c9a-5be8f50fce34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12154","original_object":"UniProtKB:P07202"}
{"id":"eb200466-738c-44d5-aac2-92d7d0cf2374","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10409562","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:57bfa5d0-4c1c-47cd-aab7-4baec365f828","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6361","original_object":"UniProtKB:P23385"}
{"id":"74b9a621-4810-4bef-ad81-0e4c0c306d9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7D07U14TK3","predicate":"biolink:affects","object":"NCBIGene:5515","sources":[{"id":"urn:uuid:68221652-ddaf-4f5b-9a27-a8685166aca7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13083","original_object":"UniProtKB:P67775"}
{"id":"369582c8-4520-49b0-859f-ec941e700d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL85606","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:08f62a79-03ee-4cd9-944e-20c340d4ecf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:143","original_object":"UniProtKB:P35462"}
{"id":"af062f87-37b7-4740-b714-f268d5b874ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2332","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:128e8c77-7345-4beb-83bf-7adbf8d9624c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2332","original_object":"UniProtKB:O15554"}
{"id":"a76f178a-8a19-4395-90ba-c217af876784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3739","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:e03a3d7c-55c6-4d11-bd15-55a7ef21bf35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3739","original_object":"UniProtKB:Q96RI0"}
{"id":"ed2f3384-9ff8-498a-abed-a396926c2537","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28197","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:0b61e852-edef-4d29-98f4-6f3f8d157ebf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2828","original_object":"UniProtKB:Q9UL62"}
{"id":"2ef583c0-04b5-4980-999f-e05378e5f015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817396","predicate":"biolink:affects","object":"NCBIGene:60432","sources":[{"id":"urn:uuid:a542b816-f79c-4627-add8-cd3273ff3bde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1144","original_object":"UniProtKB:Q9Z0W0"}
{"id":"eb793cf9-a3b4-4f4e-b9e0-028c0f179350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61014","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:f6c9856e-9661-465b-a28f-d74463a79554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:597","original_object":"UniProtKB:P50052"}
{"id":"dee35fa4-a2d3-41eb-829f-f36e4db85156","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:4af302f5-be39-49b2-8099-19940deabe22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:Q96GD4"}
{"id":"66662466-76d8-4e62-93c3-d061cb3cc39c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90851","predicate":"biolink:affects","object":"NCBIGene:5609","sources":[{"id":"urn:uuid:6dc091e1-a306-4a0a-97eb-865ae953fd24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7626","original_object":"UniProtKB:O14733"}
{"id":"752e9673-8c22-4b22-b4ca-42aa0794cdf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86474","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:750088b0-4489-49c7-ad8b-b0f4e214ba1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7338","original_object":"UniProtKB:P49768"}
{"id":"7c929004-4cc7-45c7-bd9f-f5c8421e9451","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:f63a48f6-21fe-4599-9fea-123957c7be6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P35367"}
{"id":"da810ffc-0339-4676-a101-8f2271852ce6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45073499","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:640f95ba-1e2a-48b3-9366-5427840a1361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5525","original_object":"UniProtKB:Q9Y2T6"}
{"id":"54af38b1-6e88-4fbf-9fba-ff077bac5a9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6127","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:9a590162-1179-4a20-aff8-697f97751b2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6127","original_object":"UniProtKB:O08726"}
{"id":"2fd27e53-da97-405f-8f4e-a978cce852d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:1de6fee6-f7e7-4538-8937-5d5b5770234e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:O88626"}
{"id":"813bab30-6c64-4f7c-b4fc-607ad901dd93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42549","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:5086bbfd-b539-42b5-84f0-29267ca07ee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4070","original_object":"UniProtKB:P48058"}
{"id":"23947231-a8f6-4fa6-8109-701a0449dfdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9UP25GJ6E","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:e7079a14-32f7-4c1f-916c-df5df84ec2ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1259","original_object":"UniProtKB:Q9Y5N1"}
{"id":"85443ce1-b447-4926-bb91-f6bce7ad8f5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2053","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:9546146c-e2c0-4836-b27b-958c1cad1fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2053","original_object":"UniProtKB:P32745"}
{"id":"52815bd0-f2c8-4307-b5b2-8cb12e358bcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9058I8S63D","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:fb7bf95e-97b2-4db2-98ea-1fe8f314678c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8012","original_object":"UniProtKB:P42338"}
{"id":"6b021a6f-555c-41ab-b512-2e2bfbefb3d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:29023309-9094-43ef-8119-7a046e6cb226","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30935"}
{"id":"8503bb0a-228e-4150-8173-f5e5f1155d97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94490","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:0020d392-d887-4b02-a056-e44a74c85c09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7937","original_object":"UniProtKB:Q9UQB9"}
{"id":"60eedf36-a7cc-43d6-bdcf-38ed93eb25c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:5eacbb6a-6859-4431-a03e-bc6a2d9074d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P17948"}
{"id":"d96e3d04-8340-4382-9d62-48ac6c9a0c25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827379","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:50e01a3f-58a9-4111-9e2a-09431ccb007b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8600","original_object":"UniProtKB:P08172"}
{"id":"1b002cc7-4c6e-4e8d-b8f7-89bacd71cf97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3008304","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:6e2786cb-41d0-466d-858c-cf6be1c555a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7632","original_object":"UniProtKB:P20309"}
{"id":"698839e9-c6e4-45b6-9192-607137e0cf53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996517","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:81c28578-04d9-492a-a289-8ec126f36537","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10574","original_object":"UniProtKB:P30530"}
{"id":"b19f3a6d-c60c-4233-82db-c060f2438a83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13685","predicate":"biolink:affects","object":"NCBIGene:6272","sources":[{"id":"urn:uuid:a9cc2e71-cbd9-470e-9d36-6c413fa6f874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13685","original_object":"UniProtKB:Q99523"}
{"id":"917b6c5a-b241-464f-87a6-a507a4043b22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:420HD787N9","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:c64dc46e-7236-4bff-a0fa-8438a0b205ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6640","original_object":"UniProtKB:P27338"}
{"id":"22a418ff-718f-4761-9bdf-ffde1c796705","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5017","predicate":"biolink:affects","object":"NCBIGene:10723","sources":[{"id":"urn:uuid:23202e7d-41d6-4984-9d2f-381eb034bd7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4589","original_object":"UniProtKB:Q9Y666"}
{"id":"591c2a84-26c5-48d8-be93-7ff70441d4d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3769","predicate":"biolink:affects","object":"NCBIGene:24807","sources":[{"id":"urn:uuid:f7aa45fd-b5c3-4d1b-a18c-002e3285701d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3769","original_object":"UniProtKB:P14600"}
{"id":"cc4ae82c-852d-4ba2-b917-e8da2c26f430","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:00feb409-c638-47c0-91f6-1613ec4f9e38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P30939"}
{"id":"e2c2b052-219d-4ce4-8b87-cd72c9b032cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45254510","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:f6793752-ab29-464c-8438-01c915f4016d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9639","original_object":"UniProtKB:P56817"}
{"id":"0bc1343b-90ca-4fd5-a9ca-206994600d8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:4eaebac9-f9e5-4dd5-b828-0dcc42340d90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:Q96GD4"}
{"id":"79f81ea9-c390-4282-8fd5-2d36bbdf3fcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56587994","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:f32f04f0-91e3-458a-92be-a173d17ef1ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6225","original_object":"UniProtKB:P31422"}
{"id":"7cce92bc-7d5a-4ed9-a088-9cdfb4821305","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5779","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:4b616d17-837c-4edd-ab36-7af9c9194a55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7081","original_object":"UniProtKB:P41145"}
{"id":"1b09cf55-da68-4d41-8241-c7358f216f4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:59a4381f-d0f9-4789-a4c8-aefb984ecd3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P35367"}
{"id":"f2a7e6c6-4c96-4b76-9efb-898752bcdb3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755153","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:cbbe0492-cee5-43d5-97c8-95661fe14151","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5747","original_object":"UniProtKB:Q8TDV5"}
{"id":"6ac1bbf7-8352-46d3-9889-b1995fd786cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122130461","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:fa4927fe-f340-4597-8c88-87d5ee511901","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:139","original_object":"UniProtKB:P28221"}
{"id":"6b5635cc-5117-4a4f-960e-337c7ec1fbde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91467","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:e236c13f-ecdd-46e0-b67e-5c5415194ade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9912","original_object":"UniProtKB:P04626"}
{"id":"1bb6c17d-780e-4972-8530-c2b97556704b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3899V9A17F","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:9ebe0a7e-df9c-416f-b33c-ed02bf728f7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3498","original_object":"UniProtKB:P34998"}
{"id":"d1eed910-444f-4e48-9aaf-dc2c795bac36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:88a326d7-2dbe-49bf-9a41-885a1dd46fe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:P31391"}
{"id":"aed4f363-fbc8-4d79-bf13-650dc8924fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10403687","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:6f0452ed-dcc4-4343-99cc-bd76c484b064","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1205","original_object":"UniProtKB:P35367"}
{"id":"2773b968-0399-44e9-a272-f449ed882057","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13716","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:73670cbe-9531-40d7-8caf-11fb4491ce48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13716","original_object":"UniProtKB:P04626"}
{"id":"7fa583b5-6456-49c5-bfe9-325e8943932b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121445232","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:522808c0-c667-4043-88f4-ba688122fe63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9880","original_object":"UniProtKB:P28223"}
{"id":"acc515a1-2e59-4acf-b67f-bdf9cd0ba81e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:c2a35d5a-0a3d-40f6-8185-5f1d63fd5b4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P30938"}
{"id":"e033d525-e057-4c0c-b3ce-be20eb4eab3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131180","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:836d44a4-a741-44a2-9ea6-f054e6c1bcfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:567","original_object":"UniProtKB:P07550"}
{"id":"016d0da4-1633-4c70-9b77-03afaf087404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:1a53b757-d639-49fd-a0e4-5379916c91f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:P04049"}
{"id":"779dfe59-ea5c-4f17-96f5-5c3e1b4ce713","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10405846","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:7015ff92-1928-43cb-ae9f-1c4c4f02c2ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3060","original_object":"UniProtKB:Q02769"}
{"id":"ac681044-9837-419d-b773-506b41aa08be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3775","predicate":"biolink:affects","object":"NCBIGene:3973","sources":[{"id":"urn:uuid:df447695-529a-4d0b-849b-24af4da4da03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3775","original_object":"UniProtKB:P22888"}
{"id":"37597879-7aea-4a28-af29-180edc67300b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155885713","predicate":"biolink:affects","object":"NCBIGene:4298","sources":[{"id":"urn:uuid:893c692d-888e-4ca1-af23-2df06c6b5795","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11541","original_object":"UniProtKB:Q03111"}
{"id":"acb762c5-b2f2-42e9-a549-996f16d3950b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95071","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:ecbe94a3-a131-49a5-b758-142b81801fc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8365","original_object":"UniProtKB:Q13547"}
{"id":"64fae751-989a-4549-a498-bf01de3bded1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76592","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:2b7fea04-dd06-4147-b24b-131940d7bd3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4353","original_object":"UniProtKB:P32249"}
{"id":"8a5a4919-50db-4e5a-9340-b247d2fce2bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136007","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:37515c30-6c7a-49aa-8ad5-32c5d481988e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7563","original_object":"UniProtKB:P41143"}
{"id":"79088d2c-4efa-48bd-bd19-2fc6e2e70421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ZO554A4Q8","predicate":"biolink:affects","object":"NCBIGene:1559","sources":[{"id":"urn:uuid:cb4be49d-9083-4125-a52a-b9b639388147","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10559","original_object":"UniProtKB:P11712"}
{"id":"2428d408-33ec-40cc-89a8-6f73b59440c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:74024","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:fb0a25e6-fe2a-4cb9-a850-236495eaba3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1197","original_object":"UniProtKB:P35367"}
{"id":"849226af-1bbc-4192-b410-3922ed1a289d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16046160","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:465728e2-054b-4a16-9784-e324dc816414","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1312","original_object":"UniProtKB:Q99705"}
{"id":"de4817c6-1da9-4b42-86fb-ead27190fd31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231087","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:5dceb0d8-77ee-43bb-90c0-fe09adece5f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9626","original_object":"UniProtKB:P24941"}
{"id":"c9cf98be-be13-493b-9b09-754589367cf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3654","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:a73e18b9-e595-4474-b61b-430234cdf925","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:7147","original_object":"UniProtKB:Q6IQ20"}
{"id":"443038b2-7394-4505-8d24-0fe2cf5d11ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:19316d4b-af10-4ad0-8e7d-6189770aed03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P18089"}
{"id":"dccec06c-5825-4327-a787-0697860e273d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13365","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:fbfd5fc2-b416-494a-82f5-92510059ea79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13365","original_object":"UniProtKB:P25774"}
{"id":"47db5cf2-eb44-4de7-80ba-648e401b48c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131793","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:e900864c-5db1-4501-8be4-1bde618d88e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:935","original_object":"UniProtKB:P21728"}
{"id":"ba75aae4-c0b7-4d7b-9a88-5bfc4100770e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135018","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:bf664ca6-9e9f-4953-9915-a5ac8544a4ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1610","original_object":"UniProtKB:P41145"}
{"id":"be0608c0-a11e-489b-b2cb-2f350b2d8005","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:62753e46-4186-484b-94c6-f6b0c73015db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P30936"}
{"id":"624b6822-3567-49be-89ac-604a81defab6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47781","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:ae23a9e6-77a5-493e-b7db-bdc5d0246285","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2399","original_object":"UniProtKB:P48545"}
{"id":"ff0c2043-ae89-4f79-b57d-3d1125dff44e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5866327","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:f8694aa8-86ae-4d92-a149-84f4f0798cd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1416","original_object":"UniProtKB:P35349"}
{"id":"a1873c45-ca20-4e96-95c7-56a1c979da3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138678754","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:3730013e-257d-4c41-bfc3-e4d0a063b52c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10677","original_object":"UniProtKB:P01116"}
{"id":"c4ea5533-c924-46e5-9b50-3b0e65848c82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122390213","predicate":"biolink:affects","object":"NCBIGene:747","sources":[{"id":"urn:uuid:6a4507eb-dc2d-4822-8830-dcbfccbb50f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10246","original_object":"UniProtKB:Q9Y4D2"}
{"id":"cda19afb-055d-4ae0-8f15-025515ebe0e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172333","predicate":"biolink:affects","object":"NCBIGene:1579","sources":[{"id":"urn:uuid:f311de0d-5dbc-43f1-916e-4f3cf5fb551a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11373","original_object":"UniProtKB:Q02928"}
{"id":"e0d3e2c0-554c-4a9e-85b4-80ae70f71b55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2273","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:83007914-a2df-4480-aa21-3636a9630b7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2273","original_object":"UniProtKB:P30083"}
{"id":"6129e73d-91a5-4ea5-b5ad-5c2fff6aeded","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6905","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:e1c5e430-82c6-4ebd-ae22-e144b5499f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6905","original_object":"UniProtKB:P30556"}
{"id":"b77b3494-5106-4c64-a987-44471c5506ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WDT28B7071","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:111cce74-d610-4a50-a718-41d264f7519f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10269","original_object":"UniProtKB:Q96RI0"}
{"id":"505fc937-5276-4cf8-8a5a-6dc0f0c77e57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:552135a8-1e6f-4ed3-881f-cf3316cd0ffe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:O14649"}
{"id":"a307d770-7b2e-43ce-aca7-0f4f642ede8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65326","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:b99d5794-d60b-43cd-9c2f-946d3ca11ce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5682","original_object":"UniProtKB:P42336"}
{"id":"ceeb8582-836b-424d-a993-e0868d8a4a5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:0ef374b4-e4be-4a3b-91db-3f22fbd2731d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P70597"}
{"id":"d4044523-1719-4609-9bf0-1395c3aa2245","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:0282d6ab-216c-4b6a-8f1e-6f28a41c9a06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P28222"}
{"id":"7cd6ca57-f23c-4a90-bc2c-52de61d420bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162423070","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:9bd76b6e-50d6-4efc-b127-f7c156b825df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12531","original_object":"UniProtKB:Q9Y210"}
{"id":"ceaecf55-584e-4960-8d4f-b0fba301f8a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94720","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:1d60cf45-cd91-425f-8568-5c26ebc0a06d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9397","original_object":"UniProtKB:O14965"}
{"id":"53035e4e-c5a7-4e67-8947-df148d0af808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90200922","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:6ffd8ca9-fc5d-487e-b24e-db8b036ee5d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12165","original_object":"UniProtKB:P07550"}
{"id":"48be7f98-25e8-46a2-a920-c9f5de13d4c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:53949","sources":[{"id":"urn:uuid:501ad866-1c11-475a-90e7-fb57fb03b3fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08911"}
{"id":"ad7a4374-f215-428d-9ab4-c6146d9c2244","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2627","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:9c62f93f-cc7b-4766-942d-1f63b500665e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2627","original_object":"UniProtKB:P15390"}
{"id":"a946a12f-a10c-45f1-85bb-05e0609a0998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8351","predicate":"biolink:affects","object":"NCBIGene:242093","sources":[{"id":"urn:uuid:4f802be7-0ed2-4baa-8a65-39fb684d1d08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8351","original_object":"UniProtKB:Q7TQP4"}
{"id":"79e2a3a4-f355-4a9b-8e3e-ce329c298184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9943","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:bf19b1ae-917f-4728-b245-ba95185e8a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7321","original_object":"UniProtKB:P23975"}
{"id":"f415ccdb-6d21-4737-8091-34c63235bded","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91393","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:2b13c346-52a5-4a6d-a67b-b868c87166f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9133","original_object":"UniProtKB:P08581"}
{"id":"6b22e2ca-864b-412e-a696-7c2a832f8780","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438353","predicate":"biolink:affects","object":"NCBIGene:24613","sources":[{"id":"urn:uuid:b09fed8a-dfe0-42fe-b8c8-8c2acae43e29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1634","original_object":"UniProtKB:P33533"}
{"id":"b0dc756a-9524-445c-9d34-f83e746a82a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7009","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:d080b972-271f-46ba-bf65-ad3f854ede2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12574","original_object":"UniProtKB:P08913"}
{"id":"53587042-9684-409e-a8dc-639f00666fee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44465558","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:eeac1e92-8aff-4a3c-b4cb-137413c9ce9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8196","original_object":"UniProtKB:Q9UHD2"}
{"id":"aa75e123-365c-4bf4-9021-4d7fea532b0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11278","predicate":"biolink:affects","object":"NCBIGene:2214","sources":[{"id":"urn:uuid:39d69fd7-cfbf-48ce-abeb-db401219ded0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11278","original_object":"UniProtKB:P08637"}
{"id":"82240c52-6f11-4f61-a363-1eeed422af1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TR7I0800L2","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:688c4c4b-5cdd-4a24-9cd2-b12fb63440c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4328","original_object":"UniProtKB:A8MPY1"}
{"id":"a84915b8-9e78-4356-a3b6-158db15ba1d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11384493","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:8fc8ab4a-82b2-4ebc-9535-a4a444a7bca7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1905","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"a2d9a4d2-d016-4925-aab9-fbf38321316c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40083","predicate":"biolink:affects","object":"NCBIGene:80332","sources":[{"id":"urn:uuid:13695dfc-64d2-490a-8078-fcbce9e4471e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8680","original_object":"UniProtKB:Q9BZ11"}
{"id":"46398228-fd17-4890-9b5c-6a4d6391e97d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:1cddd48f-e4d5-4b01-979e-febafd8fd2ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P31388"}
{"id":"4eed5e86-1dcd-41ab-8f03-ca5e1e9453db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:30e50604-975f-4b49-94ee-4ced498def91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P42681"}
{"id":"ae8d496a-283b-42e6-84d6-3dd211a03968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:17b0d018-e9aa-4784-b1cd-596e752beac1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P34980"}
{"id":"e1b77b64-7cee-451b-9664-4a7147deab1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:498475","sources":[{"id":"urn:uuid:33a04127-46a5-455b-ae8a-abdc4add10af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:Q9R261"}
{"id":"61258514-ec05-4c4d-8d2a-2d0e42bb0bea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114786893","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:fc2223ac-bd5b-4a9d-a6f6-5fecead130e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13697","original_object":"UniProtKB:Q13526"}
{"id":"bce2a38f-f14d-4e51-af77-c3f3ad540dc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947088","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:b98d118e-f2aa-4097-bc08-a063946db405","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2772","original_object":"UniProtKB:O75469"}
{"id":"74919121-ec95-4916-951c-370a48c69bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:ffaadf40-ab21-4ae7-bead-0fd43aa40177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"mixed_allosteric_modulation","original_subject":"GTOPDB:4366","original_object":"UniProtKB:Q16445"}
{"id":"68cb4751-5b21-4c1f-8cb1-b57145b959c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52670832","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:c459635a-c888-4b3e-86d9-8de501fe27e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7524","original_object":"UniProtKB:Q15059"}
{"id":"4cbbd3df-bc67-49e2-b3ab-8a8eddfe8af2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:170123","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:d97d972d-f4c7-4c81-9c01-c3cc4d157154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2936","original_object":"UniProtKB:Q9UBY5"}
{"id":"831378e7-76b0-44ea-856c-ad1a22247650","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:520819","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:a48757c7-cb49-4117-8750-bd6b476f430b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4191","original_object":"UniProtKB:Q9P0L9"}
{"id":"24c955f4-a988-4421-bbb8-fb227e186830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93452","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:c7cad500-ec68-419e-be41-40bcc0aec6a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4296","original_object":"UniProtKB:P34903"}
{"id":"bf72d70c-5702-4c0e-bdee-99d50521357e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71817810","predicate":"biolink:affects","object":"NCBIGene:51752","sources":[{"id":"urn:uuid:25d84d04-9349-4469-baad-3e46c3b3e503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8666","original_object":"UniProtKB:Q9NZ08"}
{"id":"98c6aefe-3e89-48a8-8763-f0f0867d4f19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:64a4a495-4ddf-4fb2-8ab2-c90167ba63b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q9HBW0"}
{"id":"aa4febed-1e50-40de-9bdd-dc661308c6d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30154","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:ea8a7b24-f9f4-4031-9a08-40fadce3f987","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2759","original_object":"UniProtKB:O75469"}
{"id":"4223d4bf-8310-435f-904f-a92ec8cd6021","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1107","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:3656c91b-de4f-4ce8-8503-1f042f185575","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1107","original_object":"UniProtKB:Q02644"}
{"id":"32498265-af7e-4103-bada-79b5099a8033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:100922","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:f810f0d2-0288-4e17-bbe5-d0abae661dc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6049","original_object":"UniProtKB:P36897"}
{"id":"1c48d608-fbf5-485a-92bc-60833fb8dfe1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90369","predicate":"biolink:affects","object":"NCBIGene:23411","sources":[{"id":"urn:uuid:a66ef3c0-ef5f-42b2-a9cd-7ce5a121ec0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8100","original_object":"UniProtKB:Q96EB6"}
{"id":"90ca6adf-bc46-48ae-b048-3943ec6aeb5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4B93MGE4AL","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:f0206273-5a1d-4d6f-b5bb-fb57733ec48a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9786","original_object":"UniProtKB:P22455"}
{"id":"731bb8f8-829b-4a95-8a7f-5bfe7c3bfcf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75W6I8W6OU","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:773ba9cc-c98e-4870-ab90-91663822fc1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4249","original_object":"UniProtKB:P42263"}
{"id":"9d5f6d6d-f4bf-40bb-9722-b649b4b214c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8K8XT2KBG3","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:d2f224ec-e5d9-4119-9044-63b20e0bc8c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9398","original_object":"UniProtKB:O14920"}
{"id":"0fda9f96-19cf-4f88-87ef-2e4448e1bebd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72943563","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:df4f97a6-4f93-4036-afaa-b2d5312351e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10643","original_object":"UniProtKB:P51449"}
{"id":"18213fd9-0d08-4609-8ba7-1b9d8ed7b217","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33569","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:66674ea0-e72a-4fa5-8af7-e447d928168c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:484","original_object":"UniProtKB:P21918"}
{"id":"17f5a850-1700-4acd-8b83-ff3095dd969b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6956374","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:adf27c29-adbb-45cf-926a-b611cdea5344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:902","original_object":"UniProtKB:P32239"}
{"id":"654a39de-bf5e-4ec8-a981-36dfea43ea8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:29553","sources":[{"id":"urn:uuid:f423d16b-a5bb-4f4c-a216-61063eb25306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:O54912"}
{"id":"5f5079ba-49eb-4324-8be9-c022e41ceb2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2CQ62IWB67","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:0be444e4-1337-494c-ab7b-3631919dffb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6475","original_object":"UniProtKB:P56817"}
{"id":"970f908f-817f-4a40-a381-62becf6996b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15428","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:5e1def9d-5b35-4c0c-bf21-77fb140e92f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:727","original_object":"UniProtKB:Q14957"}
{"id":"715e38ae-fa6d-4b55-9045-caf2381dc8ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40823","predicate":"biolink:affects","object":"UniProtKB:P35520","sources":[{"id":"urn:uuid:6abe9c75-ff82-4326-be1e-5130397d547e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5136","original_object":"UniProtKB:P35520"}
{"id":"9255b84a-d596-4e62-8701-3dd5d24b22c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656767","predicate":"biolink:affects","object":"NCBIGene:16492","sources":[{"id":"urn:uuid:cf942660-c881-4ee1-8780-70854f1fbdb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2558","original_object":"UniProtKB:Q61423"}
{"id":"3ff5ee95-2dad-4383-af60-68b9dbcaaf36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:9eb10379-ee55-4baf-b567-32fc60d17fa2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P28222"}
{"id":"f42935b0-3672-45b8-977f-8eef4953832b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755245","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:91f5fed5-5686-4bbe-8b0f-8ce94ea9c71f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6895","original_object":"UniProtKB:P30556"}
{"id":"bf72b4f0-89c9-46cb-b17f-90d0e93caf60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165416585","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:85292fb4-0e28-444d-a607-fb425aaf69e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12279","original_object":"UniProtKB:P01116"}
{"id":"42bffedf-363f-4643-8770-54deb33a1a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:961606","predicate":"biolink:affects","object":"NCBIGene:8013","sources":[{"id":"urn:uuid:42ee2a9f-71f9-407f-8eca-db923802a3da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12997","original_object":"UniProtKB:Q92570"}
{"id":"005486c4-7765-4922-8f11-aebd558a5725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:30348eb1-44e7-4c67-a47c-dc542993119c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:Q9Y463"}
{"id":"857a5059-34e4-4ca6-b474-230a3884d1c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755256","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:ed792051-2403-495e-9db8-5620e665a3fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7024","original_object":"UniProtKB:O60341"}
{"id":"f0a7813c-17ed-4765-bcfd-45849859856b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6101","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:2a46d442-1f1f-4730-a206-fef452bebbca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6101","original_object":"UniProtKB:P47211"}
{"id":"25acb67f-fd3b-45b2-a612-97eee1ac106e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:ae46bdeb-a657-4bc4-886f-0cb89b3c9e8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P42345"}
{"id":"89b6759a-c23a-4943-bf4d-0c18baf64b0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023738","predicate":"biolink:affects","object":"NCBIGene:27330","sources":[{"id":"urn:uuid:ad188da9-8b60-45b0-8289-02a5e290113e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8038","original_object":"UniProtKB:Q9UK32"}
{"id":"6524c0bb-09cb-4227-afd9-5a3f565ea11d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340686","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:eae41c36-efc5-489f-ac2a-9d681532ead5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8058","original_object":"UniProtKB:P45983"}
{"id":"d3d96f33-20c8-4ca0-8bd6-dd419c191b96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:174627","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:02108828-8e0d-4168-91c3-32f3953cbadc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6999","original_object":"UniProtKB:Q09472"}
{"id":"ac66aeab-9a3f-4193-9de4-ad6320347552","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138319675","predicate":"biolink:affects","object":"NCBIGene:79792","sources":[{"id":"urn:uuid:397928e8-5011-44ca-af0a-8f8e7d6eef77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13324","original_object":"UniProtKB:P57764"}
{"id":"caa59bda-f503-4cf1-a06b-2a940da6eabf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13841","sources":[{"id":"urn:uuid:15ae396a-a5b7-49e9-98d7-4b3e59b4c38f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:Q61772"}
{"id":"fd53c39a-3adc-4b52-af23-cb46ebeb4bef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:26946","sources":[{"id":"urn:uuid:5ebddfd9-6adf-4363-b5ab-6d86b36ac850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q9WVC5"}
{"id":"a68141db-bbe6-4ee4-977f-3ff801a15b09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:0682d888-ecb0-4972-a658-b4b7437686ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P43088"}
{"id":"18db8701-6763-4122-b98d-2e979cbc6e9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5017","predicate":"biolink:affects","object":"NCBIGene:57468","sources":[{"id":"urn:uuid:9c8a5114-14bc-46cd-ba60-fd716cf92abd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4589","original_object":"UniProtKB:Q9H2X9"}
{"id":"8f49eca2-1685-46a8-beaf-510b8fcb21c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:66026","sources":[{"id":"urn:uuid:06c4f2a6-0166-41e2-955b-f3d8b6947cd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9ERZ8"}
{"id":"fc38eaf1-b063-45ae-9207-8721046166b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134726","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:679234b6-068b-4206-9bd1-858e4ac7f4df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5608","original_object":"UniProtKB:P30542"}
{"id":"6354db84-f2c2-4aad-9bf7-78ff32f58c13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1284","predicate":"biolink:affects","object":"NCBIGene:78976","sources":[{"id":"urn:uuid:0964a092-58d6-4d87-936c-83451b144ab8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1284","original_object":"UniProtKB:Q924U1"}
{"id":"47534fca-c9f0-44ec-80a9-c431e40c4b3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3171","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:63fbf765-676a-4762-aaa3-983d9feac866","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1603","original_object":"UniProtKB:P35372"}
{"id":"143e9090-0ca5-40d7-9384-6d8196d1e91a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166101565","predicate":"biolink:affects","object":"NCBIGene:55811","sources":[{"id":"urn:uuid:ec49b6cf-6539-45a1-b6f6-358e3755f8e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12309","original_object":"UniProtKB:Q96PN6"}
{"id":"76bf733b-2f24-4bd8-9c39-68c62ebe21fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2276","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:1be45941-9229-41d8-aa1f-1b807fce4a50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2276","original_object":"UniProtKB:P41587"}
{"id":"06f77629-3ac7-46ee-a76a-a824ca49fff7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10025114","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:9a965049-e0e2-4a93-b85c-13c20501d5c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4079","original_object":"UniProtKB:Q05586"}
{"id":"e4790cc2-4dfc-4849-9d4a-a2ddf4d56964","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229526","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:77e7f6ef-dd99-4423-ab3a-d78385ef8100","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8448","original_object":"UniProtKB:P25101"}
{"id":"47d9258d-b910-4f76-b84b-275b866e74a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10350027","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:02d6aad2-49c1-4f2c-8f94-20f7af9fd270","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:365","original_object":"UniProtKB:P08172"}
{"id":"d295f9c5-013b-47f5-9305-57740296404e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50796983","predicate":"biolink:affects","object":"NCBIGene:8805","sources":[{"id":"urn:uuid:483a426a-abb5-4c7b-95ac-8af0ce930421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8396","original_object":"UniProtKB:O15164"}
{"id":"0fd994c0-0532-4388-a51b-2d7f9a473f45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1122","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:783c1670-a896-4633-a05c-3548311ddd93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1122","original_object":"UniProtKB:Q02644"}
{"id":"15a4efe0-b65d-4d91-a9d4-e9beed16ed15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175603","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:0987eb9e-60c4-4db0-889e-9ddad32e0989","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:420","original_object":"UniProtKB:P29274"}
{"id":"a028d182-f6c9-4827-8a92-dea1011cea04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:b6a8b211-9f27-4d85-ad79-b423abaefa7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P34969"}
{"id":"09f773df-7565-4c23-b833-ebef6564c394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:5a4834d4-c0d6-4452-8eeb-9f1a0affab9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:P56524"}
{"id":"ca6e54e8-3b46-4fec-af6a-55bb6ae57184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911391","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:95eaaa6b-b5da-462f-8e4f-95a52e19b784","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12983","original_object":"UniProtKB:P00533"}
{"id":"0f41b339-219f-4a4f-ac53-2c022ab40526","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FPJWORQEGI","predicate":"biolink:affects","object":"NCBIGene:5781","sources":[{"id":"urn:uuid:688cd628-2443-48fc-af07-184b676ce3b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12068","original_object":"UniProtKB:Q06124"}
{"id":"dabe1299-d9eb-4255-9e8c-5905f21bc59b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108235","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:e5c54645-5ab5-4822-a059-3f0a59454216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3071","original_object":"UniProtKB:Q02769"}
{"id":"5946f529-4200-4b7f-90e9-a22683fd2ce5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70686617","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:8a230831-e240-4111-84aa-da441b188dea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1003","original_object":"UniProtKB:P25101"}
{"id":"32f13e25-7937-4f7e-9e44-cea9e5b071ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8737","predicate":"biolink:affects","object":"NCBIGene:6520","sources":[{"id":"urn:uuid:69936f63-9932-4ec2-b114-e14b6e971b11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8737","original_object":"UniProtKB:P08195"}
{"id":"167f2067-2d51-4ef4-9275-1f05606ada83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2X066A8676","predicate":"biolink:affects","object":"NCBIGene:6868","sources":[{"id":"urn:uuid:59667bf7-04ac-4b9b-87fc-cfb61b70c3ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6509","original_object":"UniProtKB:P78536"}
{"id":"f096e192-f54b-48a5-8342-9dda1948fab9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G6GSO9SDNJ","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:02a30e44-ea6a-4b2d-9832-97f6fd788b14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9852","original_object":"UniProtKB:P27815"}
{"id":"77ba577a-fb03-45c3-8272-587e59c92c7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3G4GVP38EC","predicate":"biolink:affects","object":"NCBIGene:7054","sources":[{"id":"urn:uuid:9edc96a2-c58d-481d-8e9b-175fc3eccc89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5095","original_object":"UniProtKB:P07101"}
{"id":"3e75f7b1-7c18-4d0a-a21a-4f2a34605a70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94302","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:32b95c46-510a-4c09-81d9-0e7da9f5253a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8011","original_object":"UniProtKB:P78527"}
{"id":"0dd6fa2c-309d-4108-bfa6-456cce3f2eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:73c94320-fb54-4d98-928a-c5ccc6462d06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P28335"}
{"id":"3475949a-fc0d-4d09-a5d3-7a37e7b80c04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:fa03bacf-c00f-4ccb-94a3-e3e307a58669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:Q9UL62"}
{"id":"9c425c61-ab59-4c51-a3e6-16ce5ce40c8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:27102","sources":[{"id":"urn:uuid:aa3278a3-adb2-45a7-bdfe-a93790b5f353","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q9BQI3"}
{"id":"9311ae21-5efe-4b9f-aae4-483302184671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1021","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:ed64237b-1ea7-4abb-b70d-f86cca1d35f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1021","original_object":"UniProtKB:P33766"}
{"id":"b0d6e3db-2681-420e-ba62-fe1fcce570a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448902","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:dbb2c861-c835-4f80-826a-3d98bd39f19e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12485","original_object":"UniProtKB:P22455"}
{"id":"4ec06f4f-376e-4269-92f1-fb0c1764fcc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2069","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:b11cb418-b7e6-4ea0-bde5-e575204823d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2069","original_object":"UniProtKB:P30936"}
{"id":"3f9a678c-3829-4991-8764-68fb525630e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90195","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:c9c57054-8e19-41c9-afaa-61e06a45c1dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8367","original_object":"UniProtKB:Q92769"}
{"id":"9dccfabb-346b-4928-94ca-2a39a621ba97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:e664cc27-f50d-4918-878c-02d8391df3e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P41595"}
{"id":"61a414ce-19a4-44dd-b715-9c87d02899cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559100","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:6a77434c-909e-424a-b8ae-583fbdde77d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:219","original_object":"UniProtKB:P50406"}
{"id":"f1ed055e-c420-42b5-a223-29248c499a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:7b492d40-7ab6-4c1f-8a5c-8e0dffef31bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:Q15059"}
{"id":"c04bad38-5a93-4dcb-8d18-8ada9c7ddff1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188072","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:7837ee57-8642-411a-865a-79a0cc5309b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:67","original_object":"UniProtKB:P08908"}
{"id":"e4ba11ce-fd0d-46c3-8f55-92be0c6a0901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H327N08IPV","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:9a42b1d0-958b-4233-b0f0-bf13d1604b1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4115","original_object":"UniProtKB:P56373"}
{"id":"43b1090a-f41c-44db-8c11-456eae90d2c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92300","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:41a0d472-e5c9-40d7-90ff-1c2d990cdb25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5982","original_object":"UniProtKB:P36888"}
{"id":"9164d014-eadf-4ce7-9516-fd3d93c732c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9316","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:f4f700a5-afff-440d-ad8c-4fa07b4f2341","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3534","original_object":"UniProtKB:P35372"}
{"id":"43665f3c-30c3-49e0-93ca-b37ddd1a1b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"UniProtKB:Q01956","sources":[{"id":"urn:uuid:4e82a72e-3fec-4d18-a945-ad12ba5c686d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q01956"}
{"id":"a69f6892-8b72-45c1-93be-53b1a3a7d74b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83527","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:1461335e-5234-4b9a-ab0b-25931f47e6cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7158","original_object":"UniProtKB:P23975"}
{"id":"dd064d54-b364-4ea5-8b68-4da605d12e8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8536","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:6f9da5e1-d08a-44a8-9553-a0ae9357d20e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8536","original_object":"UniProtKB:P61073"}
{"id":"667542f1-4e7d-435e-b608-d515d4cc2c0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7640","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:2df74028-75fd-4359-be05-71dbb5e892f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2404","original_object":"UniProtKB:P31645"}
{"id":"ae201bf3-ccaf-4b85-a830-050fcbfef8af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93239","predicate":"biolink:affects","object":"NCBIGene:55818","sources":[{"id":"urn:uuid:1d82fa18-b2a7-4dab-b885-fd87e8d720bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8230","original_object":"UniProtKB:Q9Y4C1"}
{"id":"7d236bfa-d24b-4d9b-b899-29a52774a09c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:09de6abe-7752-49ad-afc8-be17cfb9bb83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P08172"}
{"id":"2814edec-353d-4188-b007-9f201c23f350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73442760","predicate":"biolink:affects","object":"NCBIGene:817","sources":[{"id":"urn:uuid:50ee5888-0f01-468d-86f1-4d67d573d5df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9366","original_object":"UniProtKB:Q13557"}
{"id":"3fb911c9-1692-4d4a-87c4-c1d9879986b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10410511","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:1f0f412c-924c-45ff-8346-53ed72d20fa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5721","original_object":"UniProtKB:Q8TDV5"}
{"id":"828bcae5-80b0-4f6f-89f0-55dcdaa31ca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129234005","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:1cabbfb5-8b91-4946-a87f-49b35ccd480f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12239","original_object":"UniProtKB:P42680"}
{"id":"f639a379-9d05-4683-9986-4a84bb5d3387","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11362035","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:c447534f-bd5d-4c0a-9a1a-9bc09e451d67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6329","original_object":"UniProtKB:Q14416"}
{"id":"2095c49a-83dd-449f-ac13-fb30c6035d9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91419","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:e15618bc-b5bc-48e8-9b4a-32017eaa2f62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8473","original_object":"UniProtKB:P24941"}
{"id":"cec6a72c-8f1c-4f5e-b9eb-76dd2fbb806a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3165","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:8a24a1b9-676a-42e0-8337-d855b8060348","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:649","original_object":"UniProtKB:P46663"}
{"id":"35a52a22-a3e5-4978-aa05-146c9dc9d491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94691","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:092aaf5a-2c8d-49af-bc56-e55136993b44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5715","original_object":"UniProtKB:P48736"}
{"id":"2e642da0-1bbc-4134-bce1-38295f6baa20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:b25db38e-4f88-4630-940b-3f7a36e284dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P28221"}
{"id":"13b7b72c-5c03-4890-9ef6-47c67b2289d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11673921","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:f26f8eab-0a9f-4fdc-946b-e31534b628d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4118","original_object":"UniProtKB:Q99572"}
{"id":"026fd0c3-92f1-413b-9317-944e4f28fe7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13842","sources":[{"id":"urn:uuid:3b19dc47-595e-4406-8689-a9ac79afc6af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:O09127"}
{"id":"86b92b21-6223-43c4-8107-5f0da679cdd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:16ZDH50O1U","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:87e8ba99-bd42-49a0-bfca-68ede4202145","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9210","original_object":"UniProtKB:P28482"}
{"id":"70c0b6d8-363d-4be7-8422-44f4370f6f3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94720","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:999601a4-26f3-4481-a585-b67ec1c3ee41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9397","original_object":"UniProtKB:Q96GD4"}
{"id":"2ae60dc8-e0cd-4a67-988a-10f3f535006f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93519","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:a0dca5fb-66cd-46f4-920e-5a91d6204725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:187","original_object":"UniProtKB:P08909"}
{"id":"7b48f769-f4e6-4101-b179-c9fe5ae78f4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49853203","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:0c352f2a-8a81-42dc-bee0-0b78d6908512","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12846","original_object":"UniProtKB:Q16539"}
{"id":"35130d8d-1f17-4e05-a71c-c91941cf9f12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321159","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:59367df1-b95a-4ba2-b8fb-0641546caa4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10156","original_object":"UniProtKB:P29597"}
{"id":"fb077583-49e8-4df7-a461-6eebd8e70b6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35420","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:cd6e4452-a1e0-41e6-8364-950a4b2be2d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4290","original_object":"UniProtKB:P23416"}
{"id":"dcf032be-1e27-46bf-acbb-2bea6679767b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93369","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:fa9492e7-7b19-4f50-a381-f1da3822c352","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:85","original_object":"UniProtKB:P28566"}
{"id":"4b3e9174-cbc9-441e-99bd-a0ec70452617","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2618","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:0a013e94-fb4d-4ffe-9c1c-dac2ae5dce0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2618","original_object":"UniProtKB:P04775"}
{"id":"7e385c57-d074-475b-a276-9a8bad003e4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699446","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:4bad3c21-e8f5-46b2-ae3e-54528b7aeb0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11130","original_object":"UniProtKB:Q03181"}
{"id":"b83ae8f1-dd4b-47f8-83a3-aca6a386eda4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10454","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:c8dea1c3-7d02-4d43-bc58-19484865a9f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:948","original_object":"UniProtKB:P14416"}
{"id":"d4e377d0-7b63-4555-b940-04641655be14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:99GS5XTB51","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:3ec97677-cccb-4b5c-8bdb-d483fb8107ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9696","original_object":"UniProtKB:O60674"}
{"id":"d59dc62f-71fd-42e5-bec5-4374abb19842","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MP564IFE34","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:29b3b0cd-47a6-4376-a283-44a7824d23dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:512","original_object":"UniProtKB:P23944"}
{"id":"4694907b-260a-4fe6-9150-ed7f7f369d8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50931","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:a1ef81ec-81eb-4a47-9842-fdda20cf72b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11976","original_object":"UniProtKB:P35367"}
{"id":"703c1eaa-4dac-4bed-89ee-c8ebe351f6d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7930","predicate":"biolink:affects","object":"NCBIGene:25750","sources":[{"id":"urn:uuid:681e29d0-d87d-4941-b292-8e66399d9a07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7262","original_object":"UniProtKB:P19643"}
{"id":"459b8ace-6bec-438a-94bd-9a6dff2dadef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169448380","predicate":"biolink:affects","object":"NCBIGene:55193","sources":[{"id":"urn:uuid:be487146-b0ac-43e4-9bb4-fb1eaf635954","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13104","original_object":"UniProtKB:Q86U86"}
{"id":"8105522e-3d56-4626-aa03-0c58270a33e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:836002","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:57e707f9-6b21-46ef-ad62-f3b42a46a4eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6234","original_object":"UniProtKB:Q14833"}
{"id":"614a7550-e872-40f2-b488-d19e56921b7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44465558","predicate":"biolink:affects","object":"NCBIGene:4140","sources":[{"id":"urn:uuid:7da4ab51-3fce-4f54-b9c4-3ef06b695b9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8196","original_object":"UniProtKB:P27448"}
{"id":"d37f4f56-07e6-43eb-8021-d722e86992e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11948463","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:1ad363cc-0765-48c5-a8d0-9823c6be9d28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6183","original_object":"UniProtKB:P30550"}
{"id":"2220cccb-1ff2-41fa-bc77-8dc9f8c62725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164712","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:838ae865-6741-4e68-8602-2e78c5131719","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2178","original_object":"UniProtKB:P30559"}
{"id":"73f1315e-4c2c-4b00-9a61-44e99bdcf567","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:a630483e-1434-4031-8745-d4f3b0a6ec0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:P13631"}
{"id":"76261139-c78f-43c9-8443-1cf820f2fb48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95066","predicate":"biolink:affects","object":"NCBIGene:6446","sources":[{"id":"urn:uuid:94681d7e-9503-4b2e-a59b-bbf2c0dfc4e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8040","original_object":"UniProtKB:O00141"}
{"id":"13d0402c-7c96-4c40-8da1-29a767e535f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28077","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:11f7f9ca-d3cc-4d99-9c57-6a7078b48680","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2765","original_object":"UniProtKB:Q9Y6L6"}
{"id":"41622e4b-483b-4ffa-8a2e-263632f47899","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947035","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:d9fcd2df-6b21-466a-90ae-57282b22d94b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2991","original_object":"UniProtKB:P04035"}
{"id":"a4a4d4ce-ea73-4e5c-b25e-e4e36edc2c85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91368","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:522845ef-176a-4b93-879c-ba2bf9363929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5693","original_object":"UniProtKB:P05771"}
{"id":"7c104ed6-cb60-4678-bbfc-604e04db5c3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:204202","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:39272e6c-d34d-43d1-b611-011417c4e0fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3117","original_object":"UniProtKB:Q02769"}
{"id":"e148f316-18d0-4e43-9263-73e509b13753","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139344142","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:4c926c40-e3cf-4975-b0c8-b9fcc3bdc32e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12893","original_object":"UniProtKB:P51679"}
{"id":"7fa00917-c162-4eaf-93fc-3763a75946b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9584673","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:9982a688-b782-4f50-8fd4-171798a56aba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4134","original_object":"UniProtKB:Q8BLA8"}
{"id":"ff7b5b05-e99b-428e-a4fc-4ab4d9eed5bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8R4A7GDZ1D","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:b82c4b91-36ee-4e5c-831b-a98fe17b3872","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7034","original_object":"UniProtKB:O60885"}
{"id":"60ca7710-bd17-49eb-b23b-f7c664d860b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996525","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:e7f22d15-d55d-483b-8790-b0994383a701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10595","original_object":"UniProtKB:Q16581"}
{"id":"8f522fdb-9d04-422e-89fb-8272671e0471","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:77b807f7-13a2-4c9b-bb0b-1ad020c193a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P29275"}
{"id":"a55b97ed-aa70-4e0c-880e-4251f37f45f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:3830b046-d813-4d47-86a9-95a2439c7df9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:P35349"}
{"id":"443b2b3a-0ef3-48f6-a19a-825a38223384","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2479","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:e7d16587-a64e-4e24-9ec0-fbcb49e43ad7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2479","original_object":"UniProtKB:Q9P0L9"}
{"id":"ee154517-52e7-4ba6-8f56-ad2e8e687ef8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7C00L34NB9","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:e41c33ae-8069-4cc4-8b0e-33755888cdef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11137","original_object":"UniProtKB:Q03181"}
{"id":"3aec37a9-12df-4f6b-a7b4-3b3bd9136ec0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:2f69f67d-2dbc-47a8-add1-1472997cdfce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P08912"}
{"id":"58686c8c-8207-41a5-b09a-50337945d1ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:472f47bf-0461-488e-adf0-e27197964574","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:P63142"}
{"id":"aa9471e3-d892-41f8-babe-11ee84d62555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16109435","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:6cea3c3a-19d3-49b7-ae16-ff9ab89f0538","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5607","original_object":"UniProtKB:P30542"}
{"id":"2589870a-7c07-45b7-9018-054a82b495f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91885483","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:a425da29-6fef-4f4a-b995-845703ef40da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10009","original_object":"UniProtKB:Q13255"}
{"id":"3be31bc3-860c-4873-b890-ebe1ae1eedaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92566","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:e00e5c58-c465-4865-869f-201ecd3db4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:122","original_object":"UniProtKB:P28221"}
{"id":"0fcb2818-d078-47af-9a85-8f7f04f780d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946093","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:2669695d-5752-409c-a817-ba6882bce764","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10598","original_object":"UniProtKB:P42338"}
{"id":"90beb382-3e28-4a8f-b1a8-ad3d390e7342","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42355","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:0e6a2014-c65a-4298-b5e6-f8c01fee96f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1456","original_object":"UniProtKB:O43193"}
{"id":"023bfcd6-f63f-4757-aca6-158ad159a1f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9441","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:42f03cb5-afdb-4c22-a562-161acee011b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9441","original_object":"UniProtKB:Q9UKP6"}
{"id":"b845d2eb-93d3-48cd-99f9-8ec955d032e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5615","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:4dd105ff-869c-4c94-aabf-dca90c2f1c7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5781","original_object":"UniProtKB:P21917"}
{"id":"b344410a-1bef-49a4-8fe6-b53af2bf5ffa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754996","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:fd0ebe66-f8bc-4933-bd3f-d61962eb53e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:562","original_object":"UniProtKB:P08588"}
{"id":"86518ea5-3f1b-459e-b45f-72abbef37b4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72163809","predicate":"biolink:affects","object":"NCBIGene:28996","sources":[{"id":"urn:uuid:837e1cd1-4bcd-4c2f-b0d2-9446bbb47af6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8128","original_object":"UniProtKB:Q9H2X6"}
{"id":"0d3f022f-4973-4bee-8611-88540a1604a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1550836","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:60f27746-546e-4cb8-a5de-2265ffa02da5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4031","original_object":"UniProtKB:Q9UBY5"}
{"id":"7b0b05a7-9bc9-4095-8026-84d339728a33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B5PQ8A33Q9","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:c71ee19b-c56e-4d37-af60-ca314a1de239","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10725","original_object":"UniProtKB:P35372"}
{"id":"6fbf8393-d286-49c4-9edf-c0d97bec3a2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:df0e1787-38d7-4783-a982-b2488eea5856","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P28223"}
{"id":"3cec7061-3ccb-4444-ab24-0add6703eca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51051074","predicate":"biolink:affects","object":"NCBIGene:3611","sources":[{"id":"urn:uuid:6f034d30-fcbe-418a-9164-06a709b4977f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8116","original_object":"UniProtKB:Q13418"}
{"id":"f34d6c0e-e935-4b85-bb5a-9a1868870b6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2170","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:2c331a5f-dee6-40c9-91b9-9c7750afd334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2170","original_object":"UniProtKB:P30560"}
{"id":"290cb4d6-b4af-4dd3-9200-052b24b31d3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122227","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:a2528235-e610-4603-ad6e-d722560b8062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:644","original_object":"UniProtKB:Q61125"}
{"id":"ebc7296d-ee99-4ab7-b533-81a462159ec4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O6NW23A765","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:5e0803de-0de2-41ac-ae83-2ca74305ab48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3986","original_object":"UniProtKB:P32297"}
{"id":"bef852b2-a1a8-46d4-a9bc-5cd36b7f0185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13915","predicate":"biolink:affects","object":"NCBIGene:10149","sources":[{"id":"urn:uuid:2e3164f8-9c84-411b-a14d-44701d96450e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13915","original_object":"UniProtKB:Q8IZP9"}
{"id":"27f72d66-07a0-48aa-a934-dfaee1b15690","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129202507","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:69d59c96-74b2-4443-a38a-0b33fc5f0e83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12076","original_object":"UniProtKB:Q00534"}
{"id":"18b5cf34-280c-49c5-a4e7-15b695aa667a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13390","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:b9cd50d5-8978-436f-bbd5-74150f1e4c04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13390","original_object":"UniProtKB:Q9UQD0"}
{"id":"c8f5a2e7-4437-414c-9de5-76bf3380ac89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91537","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:e681796f-cfde-4103-8f17-72bb3f232412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7665","original_object":"UniProtKB:P56696"}
{"id":"0524d567-5b30-42ee-8ea2-ebab5dc052f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2040","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:476d3ba6-352d-4c17-8166-23eeb404f96c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2040","original_object":"UniProtKB:P32745"}
{"id":"b83f3ba7-8c49-4603-aa8c-ea38a39ea0c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53320668","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:6a9952ae-7f06-46f7-88d3-fa8247ec55fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1966","original_object":"UniProtKB:P43252"}
{"id":"db43520f-d689-4df5-ac70-b56a8b5e347d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5085","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:ed022453-9c96-4430-a230-2ef683522972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5085","original_object":"UniProtKB:P35968"}
{"id":"f6243355-be17-4779-b0ea-3c4a7d34a4fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71553154","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:7cf25bdf-cd81-4e27-bb02-ba5792f30a74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8135","original_object":"UniProtKB:Q06418"}
{"id":"ad0db5ee-45de-4893-ba0b-91dc8a1cf6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:c0b43d84-68c7-4ee9-893c-4cd39ac93ce7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:P35499"}
{"id":"df991ac7-9df3-44e1-97d6-b1d9a500cbfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:767ead1a-4ec6-4e23-afd9-4814d3bb68db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q8NEC5"}
{"id":"816a7cb6-3388-4903-9641-34e898ebfcd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68534","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:d348ba58-9cb9-4022-97eb-fbc8e5ae416a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6812","original_object":"UniProtKB:P15207"}
{"id":"73890443-8046-4ea8-ac09-4297789efbfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:bd1c1c3e-247a-4065-9936-21db62555e15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P53667"}
{"id":"22dd9329-3468-4f26-928c-700c0221f85c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:b91476ab-c937-4976-a670-fbce2e55b055","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P36888"}
{"id":"72c65cd2-d613-418b-8d52-468096b92f1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755222","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:6b2973ce-8df1-4c19-972d-e3ff0c784b68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6442","original_object":"UniProtKB:P31424"}
{"id":"d5c5be39-f337-4c8e-82a4-a5720096ca6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755145","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:d6fb73de-0304-4140-8716-803ed6216d0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5712","original_object":"UniProtKB:P35968"}
{"id":"235b1f54-b3ea-464a-b9b8-ee22c720918c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155587867","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:f99a064a-97aa-4e38-81aa-c507ecae0a9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11510","original_object":"UniProtKB:P16234"}
{"id":"ef18f6af-0fb8-4ab1-8865-0b37f80648b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49872404","predicate":"biolink:affects","object":"NCBIGene:2167","sources":[{"id":"urn:uuid:cc71efcd-ee67-4f3d-9cd1-4cedf57e35a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8788","original_object":"UniProtKB:P15090"}
{"id":"12d49cbb-a739-439b-82c2-df8e1da07017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N18ZH0M4NP","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:2b91ddb0-d500-46c0-9749-f5275d2d08e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1653","original_object":"UniProtKB:P34975"}
{"id":"f0f68301-f035-4725-9c37-adaa1e694e55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:125570","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:292d45c4-65b0-4032-a50e-05c870c676f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:104","original_object":"UniProtKB:P08908"}
{"id":"2b240a5b-f4de-45a7-b30e-71c6dd9db494","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9947811","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:f651cfe2-995c-4f0a-a289-7b2626b9215f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6124","original_object":"UniProtKB:O43603"}
{"id":"8d77a5d9-4425-418f-bc40-533bbfa6672f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95129","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:7b94da37-de6b-42a4-a0a8-4fa5e13e0f81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:240","original_object":"UniProtKB:Q13639"}
{"id":"5520e08c-3ce7-4db1-b714-f2f7391cbc0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2024","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:c5084d73-76fb-466d-9358-7fb50c25d1a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2024","original_object":"UniProtKB:P30872"}
{"id":"5bb5f799-7230-447b-b578-89e95f4bb3bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122173996","predicate":"biolink:affects","object":"NCBIGene:140492","sources":[{"id":"urn:uuid:a4e92922-c7b3-4da9-a425-0b717c794a25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9317","original_object":"UniProtKB:P58390"}
{"id":"4d038e62-2d2b-4219-ad03-cd65acfedb8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164886639","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:5ac0d114-3420-4cee-9fda-8fd74d1ae7b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12120","original_object":"UniProtKB:Q9NSD7"}
{"id":"12079930-b572-4a3a-9ec6-57a8d95c919e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1098","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:439f56ad-685a-4315-903a-d33820ab291d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1098","original_object":"UniProtKB:O08725"}
{"id":"7cbc4ec5-4948-4b2f-8acd-0d2eb9d2d6e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9854289","predicate":"biolink:affects","object":"NCBIGene:7184","sources":[{"id":"urn:uuid:8bceb3e6-c390-4e54-bbf9-5e1d497d3d89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9211","original_object":"UniProtKB:P14625"}
{"id":"6bf8ef74-92fe-47b9-b106-288663efcefe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:458f2988-f60e-468a-867e-d44a80802e3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P0DMS8"}
{"id":"d2c27f27-4e66-4e8a-b325-98eebd4b940d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177472","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:b474cd71-aaee-48cf-b076-9dd28ab551a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1929","original_object":"UniProtKB:P35408"}
{"id":"42c9919b-425c-413e-929c-661a4194323a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:3368c182-379f-4ab9-9635-21ede2993dcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P35408"}
{"id":"5aef14c7-b62f-48d4-b2ae-791e7c192bf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8869","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:9e679a42-9643-4bdc-8d07-e6dd6fb759cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3176","original_object":"UniProtKB:P14324"}
{"id":"5a20dd9b-0724-44a5-bc06-a172e1a76a57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1317","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:c0531704-bd6f-452e-82cb-7a446bd9c67d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1317","original_object":"UniProtKB:Q99705"}
{"id":"ba36d766-1a06-45ee-969a-e926ef4633a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24905375","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:4f8a865b-6097-4d57-b22e-1ab22f9d239f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10334","original_object":"UniProtKB:P56726"}
{"id":"a268d447-8d9d-4d07-861a-6a6d38af61d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2230","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:54445054-3664-488c-a2bb-c4e48db88467","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2230","original_object":"UniProtKB:Q00788"}
{"id":"16b6ca36-c136-458e-a240-96a15c6300fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:79957547-d71a-4e71-8a54-0fa2fd3e54de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P35968"}
{"id":"ab7fdcf5-e56a-4695-833e-f31ae2536e7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:0cc6a140-487b-410c-803d-18175bc3a08d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P30994"}
{"id":"369d78d9-4eaf-4a79-ab0a-529e2565e67d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7W3V82OQ0P","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:2771d58b-99ae-4850-a3b1-7c671ea2687b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8250","original_object":"UniProtKB:P09619"}
{"id":"e4df0dbd-7e8b-423d-be33-eb86a3e6a6bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32368","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:467bb275-5657-4757-b5d2-a15a3c3327ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5533","original_object":"UniProtKB:Q9NQS5"}
{"id":"db0261f9-ed97-4a8a-a873-6848ca5c654d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10124389","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:2e663d75-3f7c-4ccf-ac54-c8f9df79826d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2175","original_object":"UniProtKB:P30559"}
{"id":"ca9d4af5-0a75-4780-a7f3-68a5512da78c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135928471","predicate":"biolink:affects","object":"NCBIGene:5590","sources":[{"id":"urn:uuid:0df2a8ea-18f4-41b6-a513-9ae15ebcf3ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8185","original_object":"UniProtKB:Q05513"}
{"id":"aa193274-d552-414f-9ef4-daf20e21ad51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817510","predicate":"biolink:affects","object":"NCBIGene:1544","sources":[{"id":"urn:uuid:047f4fd1-45f3-41c5-9542-84655cd3aa2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11351","original_object":"UniProtKB:P05177"}
{"id":"f1bd43fc-145b-4676-bf67-e2f1827e5235","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:412516","predicate":"biolink:affects","object":"NCBIGene:358","sources":[{"id":"urn:uuid:d2aa0878-ff64-4652-9b2b-9dae98e856d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10939","original_object":"UniProtKB:P29972"}
{"id":"9f0a0111-da8e-4305-a4d3-2fe1de288581","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:5072f882-9cc5-4747-8e6f-c9b0bf301cf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P28222"}
{"id":"076b3add-3292-4d75-a9f8-57a3cb6c1a09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156501355","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:533f509d-c4b9-4aac-b47d-5e43f63f0241","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11715","original_object":"UniProtKB:P01116"}
{"id":"76799bd3-25d4-42e2-853a-2ddc59ec0db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72200387","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:68d419c5-4315-453f-9028-08e5da884644","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9374","original_object":"UniProtKB:P11309"}
{"id":"8ccfc6f2-c65d-4fc1-93b3-214c94d652ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422753","predicate":"biolink:affects","object":"NCBIGene:4759","sources":[{"id":"urn:uuid:2f676127-e821-410a-a1be-c9d763940d1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13014","original_object":"UniProtKB:Q9Y3R4"}
{"id":"0c11b842-4b2a-4459-aa13-f52958907532","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4740","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:6ebd6171-0a5b-4c07-a8c5-2b77140340d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:345","original_object":"UniProtKB:P20309"}
{"id":"1e72d653-e8b5-48ce-9617-75d71bcc5f9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6444","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:569af8e7-7bf1-42a7-af66-7521429424b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7595","original_object":"UniProtKB:P35372"}
{"id":"05e2cca4-4af3-4980-8baf-18743978557b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71458575","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:3777e695-13f7-4931-8092-244198fd3629","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8827","original_object":"UniProtKB:P42345"}
{"id":"88f07b9b-ab1a-4897-81cd-d00d326781fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27820","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:a639ad9e-badf-4333-94d2-abbc7b2b08a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6279","original_object":"UniProtKB:Q8BLA8"}
{"id":"9707d7dc-8673-4118-970b-d843af5c4891","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71605047","predicate":"biolink:affects","object":"NCBIGene:27","sources":[{"id":"urn:uuid:3419e696-f790-45d9-b518-7068890c3ba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8147","original_object":"UniProtKB:P42684"}
{"id":"910dffab-029a-4817-a310-397f0f5087c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5388925","predicate":"biolink:affects","object":"NCBIGene:5478","sources":[{"id":"urn:uuid:060305f2-fca2-4cd9-b9fa-0ab073083f8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13322","original_object":"UniProtKB:P62937"}
{"id":"6d469553-df67-4207-8398-7bc6eba097a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16118537","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:ca89a90e-6d68-4c04-8a46-af5d1bbce657","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6357","original_object":"UniProtKB:P23385"}
{"id":"382e96b4-780c-4101-ac4f-8d502e7c60a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:d0510ed6-632e-40e8-8a20-6fea706eb882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P30938"}
{"id":"25049b60-98e1-4a7c-99e5-2cb282f7cdbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15996","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:8cbdce27-48f6-4275-b2d8-9180f5ca22e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1742","original_object":"UniProtKB:O35811"}
{"id":"099efe2b-d67b-4654-89ff-52f6de2515c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72789","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:79a9dd95-743a-4b15-a6f6-6e5c1420a9d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3933","original_object":"UniProtKB:P25090"}
{"id":"77b7f281-8609-4600-8a8e-e13fa57cd6dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:facee4d9-e0e3-4b67-866c-468fa2e6bc40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P14842"}
{"id":"ea8327c2-ad0b-43b7-be54-2a494ba858f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24949079","predicate":"biolink:affects","object":"NCBIGene:954","sources":[{"id":"urn:uuid:519e22dd-daaa-4665-ac48-943bde4a9cae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9033","original_object":"UniProtKB:Q9Y5L3"}
{"id":"88d3b34b-6d8b-451d-b882-3f17c446fbc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68299673","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:2bec0a03-653c-4215-8289-96b4196787c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13743","original_object":"UniProtKB:Q9Y243"}
{"id":"2afd4c6a-c2b1-4f76-bf9b-c89ae3a5c9c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310951","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:be6c95be-970f-4a49-9b22-6ee3ad54e93f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3826","original_object":"UniProtKB:P46663"}
{"id":"cbb9569f-02dd-4f04-9f94-22f3aec815d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368927","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:b755791c-d29b-4505-9212-4eebec44539e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12048","original_object":"UniProtKB:O60674"}
{"id":"2c845a81-65bb-4776-b268-64b5645afc3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:1e8585a9-87eb-4e4c-a954-d60f3113a8f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P14842"}
{"id":"b264889a-36d6-43f7-8c89-2091e14e9ece","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61399","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:9fcca7f1-fd59-4ab0-bcf7-8c57e15aa550","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5675","original_object":"UniProtKB:P04626"}
{"id":"5876c7bd-86a7-4664-8ab7-b5e7b20ece97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95088","predicate":"biolink:affects","object":"NCBIGene:9833","sources":[{"id":"urn:uuid:2ba14cb0-b119-4423-b146-a035436b51df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8046","original_object":"UniProtKB:Q14680"}
{"id":"02edac4f-2d69-47cd-9e75-1087d9f46d7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:c79e5446-8c05-48a1-8452-198b71e356b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:P35561"}
{"id":"d17b5bdc-2f91-402e-8ab0-9b73b52d7b29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95049","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:737a5b1c-1cd4-4aae-9185-8d235bc98bb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9375","original_object":"UniProtKB:P24941"}
{"id":"1f917602-7354-4cc1-9823-14269186628b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9017","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:47df972b-f973-4812-a1d8-d85fa20237f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13093","original_object":"UniProtKB:O43570"}
{"id":"209955b1-bb04-4eca-b052-1acff1abf653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132947","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:b955f29a-42a6-4bf8-9857-a7943fe4061c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:361","original_object":"UniProtKB:P08172"}
{"id":"9283c43e-169a-4091-96c7-323eddeda62c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T77D5438IM","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:d8a0f1d5-8df4-4280-a70a-cc3361efafcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5831","original_object":"UniProtKB:O88536"}
{"id":"819ad7eb-3c75-4c81-bfd2-5461409e004e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:2546afcb-00be-4ecd-b30c-291b0c636349","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P34903"}
{"id":"489403b5-3c24-49dd-9dc4-22814327dcbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441294","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:40237b94-1c1b-4a34-b058-f954ef93e2fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1862","original_object":"UniProtKB:P48167"}
{"id":"f0f0d843-d4f3-453a-9f09-d7e3990009bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:23617","sources":[{"id":"urn:uuid:e194bd75-eb94-479b-9522-babb0757b838","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:Q96PF2"}
{"id":"479c884d-1fbb-4af4-8955-5acc490ca0c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22133318","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:5161af98-8601-41a1-a8bd-e48ce36f6a06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1354","original_object":"UniProtKB:P49286"}
{"id":"66f81368-a434-465c-ad53-bff998f436f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:8c9d89a4-6f0f-4576-8733-6c05911350c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P41595"}
{"id":"85bb4838-7042-44d0-a91d-a21d33f8334d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164852436","predicate":"biolink:affects","object":"NCBIGene:7004","sources":[{"id":"urn:uuid:461dd34f-0fca-4ddc-a294-9e4a2b4b775b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12814","original_object":"UniProtKB:Q15561"}
{"id":"ad73081f-1774-47eb-9d09-23d10b4d1b0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926514","predicate":"biolink:affects","object":"NCBIGene:57396","sources":[{"id":"urn:uuid:8f0a3c65-6b56-47fb-aa44-6e32d718ad27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8162","original_object":"UniProtKB:Q9HAZ1"}
{"id":"d0d89a6c-2763-4f17-9940-0a7f4fec350e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1300","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:90834b59-fcb1-4bae-b54b-9eb25bec3604","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1300","original_object":"UniProtKB:Q99705"}
{"id":"efdf2da0-4c37-419f-812e-8707ade6c578","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72201027","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:36859b78-68f7-41d1-a027-04aa2545012e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7529","original_object":"UniProtKB:Q09472"}
{"id":"5993e6f4-4ce4-4288-a0ef-dab5cf552dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68181876","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:f29a8231-5e44-4170-98d5-744884d2c050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8941","original_object":"UniProtKB:Q13177"}
{"id":"c9c57416-2ca2-4119-8d40-52267732157b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11148966","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:130800f8-287a-4315-8129-a4646bcae42c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1598","original_object":"UniProtKB:P49019"}
{"id":"fc2a5b96-f223-4614-a940-59ea4464abfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:54c91f24-daa7-4097-9b46-506a498fb8e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P08908"}
{"id":"9bc951f5-2626-4379-bd39-0d881a283f7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3640","predicate":"biolink:affects","object":"NCBIGene:6559","sources":[{"id":"urn:uuid:6ec41be7-170b-47e6-b05b-fddfa39ab62d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4835","original_object":"UniProtKB:P55017"}
{"id":"cc5f87a2-6c6c-44a2-908b-7bd2524dbd91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12917","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:fe9f81f5-81ab-42bf-8701-5850b3a6b57b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12917","original_object":"UniProtKB:P04150"}
{"id":"22af4078-2811-407e-9b80-b862d0a25c30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17650","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:dc6952db-ba62-4678-8b41-ef6db2bc43bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2868","original_object":"UniProtKB:P08235"}
{"id":"85b9b3ca-fa2b-43d7-9402-92a21b235ca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15964","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:4d387ae3-6651-47a7-a7ad-2916afda1c9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12470","original_object":"UniProtKB:P59537"}
{"id":"59035219-6bbf-44c8-9b34-cb4807bf2393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5YZ3QBQ97C","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:7f97761c-26a4-4c4c-ae35-580623e24491","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6046","original_object":"UniProtKB:P43405"}
{"id":"e5514820-ac62-4e32-941e-93ba5a173cf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23649325","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:69099556-6699-4266-b34e-0b89e6168383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7360","original_object":"UniProtKB:Q9H244"}
{"id":"82617603-b08f-486a-80b1-3fdabb483a27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:6f8c7913-a6ba-4a07-850e-940caa8b09c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:O08726"}
{"id":"1df923eb-9f9f-4d07-90bf-31d3e3011d91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:16T7U12J7U","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:43599d9d-a457-4a3a-a781-0b0263bf7b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12373","original_object":"UniProtKB:Q05397"}
{"id":"baadfba5-0ea6-47c3-a3cd-31a70f93735b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13553448","predicate":"biolink:affects","object":"NCBIGene:1504","sources":[{"id":"urn:uuid:4befbebd-0b2e-4e2a-941a-2eb348eb3d5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13135","original_object":"UniProtKB:P17538"}
{"id":"7a25fbcc-1e7d-451c-a301-5111cb2086a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155749520","predicate":"biolink:affects","object":"NCBIGene:9252","sources":[{"id":"urn:uuid:ca854d4a-5a15-43f7-bfc9-5ae50118d660","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12059","original_object":"UniProtKB:O75582"}
{"id":"a441efbb-5cc0-4540-827a-df51d88ce26c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:25689","sources":[{"id":"urn:uuid:ddc83555-4114-43ab-ae5a-a3caade79bad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P35364"}
{"id":"79476b77-de1c-4971-b6d2-d1438626c608","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1812","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:864fbdb3-2cfa-49d7-802f-3fa2627c58f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1812","original_object":"UniProtKB:P25961"}
{"id":"a8e10158-f2e0-4267-bdf3-bcbe5abcd222","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:e3691620-f33c-48fb-b81a-02e161d5fbd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P14842"}
{"id":"a0defb36-b780-4418-8267-fc760c33b037","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27432","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:6283673b-dc65-4c19-93ab-9d3c255cf86a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1049","original_object":"UniProtKB:Q5NUL3"}
{"id":"e4c05bbb-2bc6-476d-90f5-a7bad80af55c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:ee79d129-6d41-46bc-9ecf-d8852ca8aab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P28647"}
{"id":"233a17c7-61ba-42ee-8442-3d8e894b4228","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1844425CLP","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:9271aae5-0cc3-4bc6-a747-1ddaa2d7a832","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5822","original_object":"UniProtKB:P43115"}
{"id":"87810d8f-50c6-4244-8d6b-59b4ed4596d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75593419","predicate":"biolink:affects","object":"NCBIGene:5126","sources":[{"id":"urn:uuid:c59618a7-ba6e-498a-b8eb-4ae4aaad712f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8658","original_object":"UniProtKB:P16519"}
{"id":"451e30df-5268-4fd9-82ff-bfed3942d8d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:4ced81e9-135a-4788-8e9f-a34ac0f341d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P21918"}
{"id":"334bd1ed-bf64-44d1-8184-19b2673f451c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:691f8e6c-bc89-499a-8238-9eac65710422","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P29275"}
{"id":"4ba49283-2512-43aa-995f-eb883c55d2e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:769","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:73f69f57-63d9-40be-bf13-93f19a746710","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:769","original_object":"UniProtKB:P51677"}
{"id":"50e20d0a-77e7-47d9-85f9-b41670504e29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47426","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:855e5a29-7cd3-49dd-9055-43fbeb505ff3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4839","original_object":"UniProtKB:Q9HC97"}
{"id":"7f785a03-fa78-438d-bc8c-e7900a19bb86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190024","predicate":"biolink:affects","object":"NCBIGene:51702","sources":[{"id":"urn:uuid:117af958-1188-41b1-a9cc-ba04fcf3aa6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8685","original_object":"UniProtKB:Q9ULW8"}
{"id":"00936a38-5fe8-4a47-b8f0-c543a0f29065","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177520","predicate":"biolink:affects","object":"NCBIGene:6868","sources":[{"id":"urn:uuid:9040844f-93a7-4d09-abdb-c3b52815305a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6482","original_object":"UniProtKB:P78536"}
{"id":"ed951f74-83bd-47c1-8e12-220631b28a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O1Q96UZ63W","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:7aec6568-415e-48d9-8c5d-cd8d18a1a6cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3281","original_object":"UniProtKB:P25099"}
{"id":"99da70bb-7ffd-42cf-8c2a-26d5ba47f02b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310936","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:d1ae60dc-888f-46d9-a03d-df4fbc89033f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1072","original_object":"UniProtKB:Q9Z0U4"}
{"id":"acb293a9-f6c9-4802-801f-917dcc05f83b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46869947","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:26261e2f-547c-4a24-b09f-fb5603d8e392","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6233","original_object":"UniProtKB:Q14833"}
{"id":"ae43723a-4689-4673-bd40-7bd067092965","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91965","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:bd874af7-700a-4c3a-84bd-5629848c5173","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1649","original_object":"UniProtKB:P41145"}
{"id":"0a076114-6130-4d3a-ae62-2cecd2016a46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R22TMY97SG","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:dff48ed2-9303-4c60-9a0d-69d87961aad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:907","original_object":"UniProtKB:P32239"}
{"id":"84a531b0-999c-43cc-9a7c-8c07af2d87e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69477","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:ad6a0c62-b68f-4e95-b9d3-deb735c4e891","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11094","original_object":"UniProtKB:Q6RI86"}
{"id":"b35543eb-4aa1-4e39-9f8e-adbca2d6efd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9TG5O4V25H","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:634d6b24-0a97-4871-b830-3c81e914c073","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9790","original_object":"UniProtKB:Q86V86"}
{"id":"98d2768f-8133-412b-8b71-a4af62015d4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56597775","predicate":"biolink:affects","object":"NCBIGene:7075","sources":[{"id":"urn:uuid:a0832377-47d5-4d14-aecd-aafcc58f8372","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8213","original_object":"UniProtKB:P35590"}
{"id":"0602adef-4c44-4ab0-937d-0ddca4ff3028","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4903","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:7af9717d-82c0-47eb-823a-a21f1816a24d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7071","original_object":"UniProtKB:Q92731"}
{"id":"8e3d08aa-e097-4d57-ae6c-d159840fa54b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:f66422e8-cc3e-432b-9400-746e55235b49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P49840"}
{"id":"b9f3f3f1-081f-4628-8200-10995f5c5423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44437220","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:07060593-36a5-4b9c-b7b4-2fd48d6312c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11081","original_object":"UniProtKB:Q14330"}
{"id":"2d2c0c2a-3411-4ef4-8647-f8621d523a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155555842","predicate":"biolink:affects","object":"NCBIGene:587","sources":[{"id":"urn:uuid:8929acdd-151a-432b-acf6-0f4b592a6341","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12232","original_object":"UniProtKB:O15382"}
{"id":"1e3f2f2e-ecc8-4802-82a8-3d7987335c6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1468","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:8de03a3c-5f92-4109-8ba9-b0cdbd4b30a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1468","original_object":"UniProtKB:Q9HB89"}
{"id":"043ca5e3-491d-4c15-9365-a0f2bb52e1cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52944285","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:6e05c535-22c6-452a-93d9-53610e883944","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6533","original_object":"UniProtKB:P07711"}
{"id":"f0bce6ab-7ec1-4b4c-80b0-a62ed48f2e80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9365","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:14a81f1e-01b7-43e6-98ca-97b6a96aa672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9365","original_object":"UniProtKB:O14757"}
{"id":"38ea6577-dd6a-49d8-ab72-2e9da95759f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"UniProtKB:Q50KZ9","sources":[{"id":"urn:uuid:fb17bc30-7b13-4114-85d9-2938323e2399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:Q50KZ9"}
{"id":"31ce6482-b384-4280-ace1-3af7b8954fd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49375","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:0bd387e0-af42-4f3c-b6d4-dcad24a5bdfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5678","original_object":"UniProtKB:P12931"}
{"id":"9cacac9b-ac0e-412e-9969-5cc6800ab4ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:0555a9b7-cb7d-4b41-94e7-58f49015e0d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P25962"}
{"id":"cfe80f43-5bf3-43ec-8099-c21023f94903","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1478","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:a24a2fd8-c361-4f5a-8708-ba519377ed1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1478","original_object":"UniProtKB:Q9Y5X5"}
{"id":"4aeccd31-dae0-4367-a1be-3f51bb04bad1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92715","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:c3fee76c-42d4-4d5c-b02c-22a66db4f5b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5994","original_object":"UniProtKB:P23458"}
{"id":"61abbe94-0d94-40b9-9936-680be200ddf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:c654d7fe-9648-4b74-be96-609ddb35d424","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P30543"}
{"id":"db460371-c7fb-4b64-837d-5e89ba57d8ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93201","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:4acc2f8f-a08e-4977-96a8-f7bd007d91c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4347","original_object":"UniProtKB:P14867"}
{"id":"c1c6a7d6-49c2-45bc-a69d-c74c73e2ff34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135496218","predicate":"biolink:affects","object":"NCBIGene:55811","sources":[{"id":"urn:uuid:63ec3bf6-4c87-40fe-919a-79d153509e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10216","original_object":"UniProtKB:Q96PN6"}
{"id":"f6a6c453-fe94-4f4e-ae28-d6877f8f715e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16285","predicate":"biolink:affects","object":"NCBIGene:20181","sources":[{"id":"urn:uuid:0fc52a2e-bb17-4dc8-9f40-f16669a5d379","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2813","original_object":"UniProtKB:P28700"}
{"id":"9fe50669-c1ee-474c-beb2-d623b2823da1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:1c558c07-d8ac-4285-bc8b-4562e35c6c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P07550"}
{"id":"4e0704e3-636c-42ba-88fd-e01914a904e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11711282","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:d8ff39b8-e2af-438b-aa37-a4b3baa69745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9446","original_object":"UniProtKB:P0DMS8"}
{"id":"0be3f2db-893c-4e14-8c5b-a3d7a995be4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92140","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:1aa4a754-50ca-4fd3-98f0-e36aba2e86d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4240","original_object":"UniProtKB:O15399"}
{"id":"df475d5b-bcaa-456e-9e23-fd7143118ff9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28209","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:57428909-c0d7-4010-8e92-f3b23e215221","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3390","original_object":"UniProtKB:Q8TDS5"}
{"id":"b9bcb9d9-419c-4d9c-be81-aaf0c548ce9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755094","predicate":"biolink:affects","object":"NCBIGene:6565","sources":[{"id":"urn:uuid:3adee8e7-24b7-46ad-bcb1-547fcc96179f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4498","original_object":"UniProtKB:Q16348"}
{"id":"280449e8-63bb-48e4-9868-d369e66afb72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76254","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:45e918ef-485d-48f0-9462-3217edb1556b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9551","original_object":"UniProtKB:P23219"}
{"id":"b6df4b70-a60c-47df-97cf-a9780be910d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11670893","predicate":"biolink:affects","object":"NCBIGene:5321","sources":[{"id":"urn:uuid:cd3240bf-3b5c-4b84-9035-c43c8843eb9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8771","original_object":"UniProtKB:P47712"}
{"id":"fb3ca7ba-d810-43fc-8aeb-a606cbd606c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13102","predicate":"biolink:affects","object":"NCBIGene:6510","sources":[{"id":"urn:uuid:d2a81a46-da71-484c-9bf9-7338705d8f41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13102","original_object":"UniProtKB:Q15758"}
{"id":"9f7b03d9-081b-4366-ac47-4fc9ae1a4e77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9958543","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:acf11acc-c344-4800-811b-3ee4a0d10d5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6743","original_object":"UniProtKB:P37231"}
{"id":"99dc3df7-b1b1-487d-9286-757423992a00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10512636","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:d79de129-39c5-4597-8b95-c0a85a6b2143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10433","original_object":"UniProtKB:O43570"}
{"id":"ee76e51a-adfc-4ba7-b5a3-2a08b5f6ccb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92352","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:d3348e2b-31a7-4196-baee-30370506a24d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5989","original_object":"UniProtKB:P49841"}
{"id":"225209f1-7818-450a-9b15-8035fa9ab92f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:59WCJ0YNWM","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:750805e1-a1f6-4a5f-a544-4a2d2dcad1aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8689","original_object":"UniProtKB:P28335"}
{"id":"b611ed46-8c66-4ba8-aecf-a87b1ebaf32d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91329","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:ffd2a8f0-d922-426c-a180-959c0451deb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7714","original_object":"UniProtKB:P42345"}
{"id":"4b1186c1-30ef-4a59-96fd-0ed0046ec174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135348858","predicate":"biolink:affects","object":"NCBIGene:79885","sources":[{"id":"urn:uuid:c3398215-0abf-4b79-9df2-ede45e822b69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10490","original_object":"UniProtKB:Q96DB2"}
{"id":"9264a076-0ecc-41ea-98f5-4774112a0070","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75913","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:aeed8f2c-2be6-45b5-a255-fab065ec6659","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5545","original_object":"UniProtKB:Q9Y2T6"}
{"id":"f5720b81-24b9-4304-b462-480ccf7ab452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41774","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:555d04fd-96b9-4624-ab14-affdb39ab204","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1016","original_object":"UniProtKB:Q92731"}
{"id":"f130ef5f-2afd-4adc-9753-b276d5dc8312","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PW3Q92Z6A4","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:849bdae4-a5ba-40e7-8974-50863f64f7e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11624","original_object":"UniProtKB:P08581"}
{"id":"836cb075-c5a1-4102-8916-662150ac65d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:754","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:8eedb85c-e5de-43f6-9c56-aa8555a1e026","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:754","original_object":"UniProtKB:P51677"}
{"id":"92914a8d-5f4b-487f-a8b2-0e10f7d100f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24754886","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:29b220f5-65ea-46b2-8e4d-542a88776ef8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8855","original_object":"UniProtKB:Q13490"}
{"id":"6b08277e-1fa0-4c0f-927b-e8360bcfe7ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29888","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:3fd5f7bc-e369-4d15-9343-24b92f39a3ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3151","original_object":"UniProtKB:P14324"}
{"id":"86cfce0f-9f31-4256-a62e-510a80c41fb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41774","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:e7b77731-4008-47e8-9d05-7c598c42dc21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1016","original_object":"UniProtKB:Q99527"}
{"id":"55e90856-b20b-4f88-a31e-d5a511ecc1e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15647","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:bdfaad9c-6ed4-445b-8bdf-26b5f455a790","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2487","original_object":"UniProtKB:Q9NPC1"}
{"id":"2f1c9823-0432-4a59-b8b8-e23fa178222a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEGM9YBNGD","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:c555ec99-ea85-47ef-b425-6ad6e1b578cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10318","original_object":"UniProtKB:P07949"}
{"id":"f7af9600-e394-41a5-a387-3d337e7ad250","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CV8JZR21A1","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:4b9ab9c7-41e2-4e4f-b92b-ca19de5bc79b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6452","original_object":"UniProtKB:P41594"}
{"id":"86372f8d-86ed-4ed9-8a73-5e1d1548c49c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45302","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:aa6447ed-9ed4-4dc3-9685-266cceff3652","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6023","original_object":"UniProtKB:P42336"}
{"id":"6dde0a50-9a64-4833-9f82-99ea7a7f64fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:0608b51c-e12e-488b-aaae-cd8ae4c59260","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P21728"}
{"id":"34101a94-e31a-4699-b9e7-746035f8d091","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23657507","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:e4d4a69c-3077-442d-85fe-c668993bca31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8146","original_object":"UniProtKB:P06239"}
{"id":"4bcb6a50-00d9-4a07-bddc-8ebd2db0c43b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139533572","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:b1a21d44-a943-4a92-b20b-3bd30892a6ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12249","original_object":"UniProtKB:P36888"}
{"id":"a50c100c-8475-44a5-95fc-873912e86c48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8982","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:854cf08b-106f-42fd-8d13-621bddd38f3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8982","original_object":"UniProtKB:P35367"}
{"id":"718c827f-3c32-4b7f-b9dd-a038739cb0d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64317","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:b7bbd6d6-753b-4d27-9e1e-a13aa119166f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:536","original_object":"UniProtKB:P26255"}
{"id":"798ebb45-cb34-401f-9699-6d7f3b929799","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71364","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:fc6238f7-fca9-48e8-906f-fc10b6daca04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:667","original_object":"UniProtKB:P30411"}
{"id":"948cd856-000a-4272-9dd9-24569a71a51e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6093161","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:229b12df-a2d7-405d-9685-e60577618b56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4267","original_object":"UniProtKB:P51575"}
{"id":"d04c7842-db4f-46f9-a05c-68d1e1df5a56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:c1f60ce7-47dc-4775-93c7-1c1e3afc2d45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P28647"}
{"id":"5ee3872f-96b0-48b3-bf11-4431e2e6f8a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185785","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:fb5e6ae0-45f0-4f68-9f05-8d99f89bcbc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9705","original_object":"UniProtKB:P34972"}
{"id":"12336f44-25f5-4dff-8d74-f115422eb7c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82720","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:efc81515-e1b1-4712-b1bb-53a9bd9a0682","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4754","original_object":"UniProtKB:P13866"}
{"id":"f27b2978-49ff-47cd-b6c0-dcb66c2f3261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG8BT6T9MB","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:3ed6e41a-e8e4-4363-aab7-3eeafc3eebad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5993","original_object":"UniProtKB:O60674"}
{"id":"0f3767e8-62ef-4b33-8f3c-ff3439edac9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101643011","predicate":"biolink:affects","object":"NCBIGene:7299","sources":[{"id":"urn:uuid:3402a5e1-75fa-4e0b-b67e-af5c43eb9fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13514","original_object":"UniProtKB:P14679"}
{"id":"efad38c9-a4ca-47a3-b5f0-63e7a658930d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5T4I78IYZ","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:c32d6f5b-8a51-46ea-a5b4-0b7b1ca29fad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12872","original_object":"UniProtKB:Q02750"}
{"id":"cc3effab-0e85-45f3-a123-72be409f1478","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:979718","predicate":"biolink:affects","object":"NCBIGene:2563","sources":[{"id":"urn:uuid:202f3de4-7e62-49bc-a258-53701d489e00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4184","original_object":"UniProtKB:O14764"}
{"id":"5d437852-3b49-4529-b8b7-f0419a4d5a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135810","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:77b478bc-7757-4264-8bc8-2a766de973b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3487","original_object":"UniProtKB:P25101"}
{"id":"914a9e7f-ce46-424c-bcd6-cf5241d4990b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50861","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c8ac9ab2-aad5-48ca-a8c3-2e88456c2d40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5820","original_object":"UniProtKB:Q13258"}
{"id":"e1fb15dd-c190-4e96-b0bf-aa019714986e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1DQI1B52Y","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:901a8096-008f-4ca8-990a-72617970c662","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9429","original_object":"UniProtKB:Q9Y243"}
{"id":"3b95bfba-beaf-4de7-8f84-bb23f8751606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4202","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:19de0e87-2b71-44f0-8841-df2230afed9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:4202","original_object":"UniProtKB:P13569"}
{"id":"9870c84f-b017-42b2-ba5b-684bde59b1b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:dbe52568-7402-4684-8d73-946e39b44156","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P28335"}
{"id":"999be372-dec2-4884-9d6f-fb850945e1e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93015","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:2bcdc1e8-47a1-42e7-b837-f290f610869d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3274","original_object":"UniProtKB:P11229"}
{"id":"aa22853a-2117-41b4-b3f1-49d803b5c992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67RM91WDHQ","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:2a72ba3b-59c6-423a-b6c0-ad31acb338ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7918","original_object":"UniProtKB:P53350"}
{"id":"87b8b204-21e6-43e8-a99d-5e8e1be9ccfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91920","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:367651bb-bca9-4912-a447-4d6424b756e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4238","original_object":"UniProtKB:P31644"}
{"id":"9532d9f0-d893-4036-83a5-0a1741795e38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132233","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:d8537bb6-7b3c-49e1-a4bd-b492622060e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4804","original_object":"UniProtKB:P43166"}
{"id":"82aff9f5-aaa7-459f-b11d-c039c2eb2885","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755062","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:bb9ea203-f660-48b2-8cc5-b3683ecb0be0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3934","original_object":"UniProtKB:P25090"}
{"id":"5ab7a782-c74f-4ee5-88f1-d4bdc54ba5e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132084","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:333cdb31-7824-4128-be2f-06205831d1dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6043","original_object":"UniProtKB:P09619"}
{"id":"84fabdd5-63bb-43bf-a3f8-adb9fc514577","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:d3153a92-2901-4092-b0d9-2b3d0c8a97b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2181","original_object":"UniProtKB:P30559"}
{"id":"26d60f5b-bc77-4250-9739-203718f64179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W4Q1543X33","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:21a88830-7adb-4ea9-9fb0-addc1d103297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3217","original_object":"UniProtKB:P50406"}
{"id":"d1c8bde7-b688-43bf-a4a1-3017702ee9b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221653","predicate":"biolink:affects","object":"NCBIGene:26253","sources":[{"id":"urn:uuid:6a767e8e-b642-473a-baaa-6d9d5704b786","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9483","original_object":"UniProtKB:Q9ULY5"}
{"id":"2998be4c-2c36-4f3b-9b7c-7b842e04a1b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:79885","sources":[{"id":"urn:uuid:e27d1957-f1f0-483a-a9d4-5eac8adb122a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q96DB2"}
{"id":"66a42ccf-1523-49e1-8bc4-73c8087bf5bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45381385","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:4a38258e-7896-4fe9-8f58-9085c4ce283b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9840","original_object":"UniProtKB:P53667"}
{"id":"4eb32c63-9094-4fdd-9089-c630793f7993","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28502","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:c8795677-9b4b-4082-9a82-c5c8b50b7903","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7310","original_object":"UniProtKB:P18089"}
{"id":"c7ffa4d9-4623-406f-9368-a80d360ec82a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2043","sources":[{"id":"urn:uuid:6bd70c94-be9f-4190-aa0b-fc85371fcf5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P54764"}
{"id":"55a7faf6-c706-4dd5-a2af-a99cd77231fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25210130","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:21b1d158-7a0b-4a57-be63-e445835c2b33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7782","original_object":"UniProtKB:P49286"}
{"id":"443a9d5e-0a15-448e-acdc-f4ef3a7a7cf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3074331","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:e1115eb5-b638-4903-9d27-d2964eb5c639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:872","original_object":"UniProtKB:P56481"}
{"id":"4efb02c8-c156-430b-bc33-edb1eef00d3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169124157","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:2a8dd4ae-1560-4be1-a1de-7d4a0c22b0c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13163","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"7c757749-45a7-4602-97b9-15549c40b787","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993641","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:1b7d4836-6a99-4d04-883d-32c954e34a3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12399","original_object":"UniProtKB:P14618"}
{"id":"d2e5450e-3461-4da4-879d-f675648dc206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2189","predicate":"biolink:affects","object":"UniProtKB:P48974","sources":[{"id":"urn:uuid:37a8c643-e594-4b74-83c7-aa620faa32f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2189","original_object":"UniProtKB:P48974"}
{"id":"cf2a0d6b-b7b3-4445-a1d5-4f0c7933e42a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3999","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:03e963f9-4951-449f-8826-172d2024e159","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3999","original_object":"UniProtKB:P02708"}
{"id":"9bdd6dac-1932-4ef4-a4f5-3db96d691e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TN7CUD1NGA","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:e1dd9e7a-89c7-4f84-abd6-e2f232e0643b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11414","original_object":"UniProtKB:P22455"}
{"id":"61c4f73f-125a-4170-8644-ffc977441730","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:78aefc7d-23b1-44fa-a677-578d5062f9aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P35561"}
{"id":"b864f4b1-7a40-48c9-9fe2-f8e63f318b98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194339","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:f5cf9576-9248-4e41-b7a5-875f9ac0dd91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7718","original_object":"UniProtKB:O43497"}
{"id":"85dfae8d-6359-4036-b7d6-2b77c6d412dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9FUT9FH3EX","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:9341c322-1c3a-405d-a02e-d86f8229a459","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8898","original_object":"UniProtKB:Q92731"}
{"id":"03ac4bad-dc0f-428c-88cb-2c27fe620ba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8305","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:c96dcc39-ae6e-4b1c-8cd7-e9ab4c5cc2c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10293","original_object":"UniProtKB:O75762"}
{"id":"8b41b45d-1b22-4d63-a988-9986e84fdddd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:816499ec-c628-4be5-96d7-29376b136447","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:Q15761"}
{"id":"4594b5f6-7e2b-4682-b14c-57253d7b4583","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231352","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:e67d3d91-1d52-458e-9709-4644e315d47e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7502","original_object":"UniProtKB:Q13547"}
{"id":"e5f4783d-3636-4b09-9f1d-4d106d7f1485","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393292","predicate":"biolink:affects","object":"NCBIGene:5146","sources":[{"id":"urn:uuid:5fd7b261-12cf-4e39-96fb-bfdbb750674c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10400","original_object":"UniProtKB:P51160"}
{"id":"7a782b0d-496f-46c4-bc1a-e9790fba45b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:af8fe651-d323-476b-935f-892bcc2998b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P11229"}
{"id":"b8886920-0379-47cd-8061-6945007d5a99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2701","sources":[{"id":"urn:uuid:1473d770-e23b-4782-8e1d-7a7afaeb5c8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P35212"}
{"id":"2cd2d6dd-9d26-45e5-b97e-2ed9ce54c7f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:dd527886-eaa7-41a8-ac03-13efca4e323c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P50406"}
{"id":"4a622a2e-25f0-49b4-86b4-82d9eab1091d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173077","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:e9e728d8-486e-4f0d-8587-819436b21974","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7875","original_object":"UniProtKB:P42336"}
{"id":"d60c2fac-0f2d-49c7-86e2-21bed9e05c9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10512636","predicate":"biolink:affects","object":"NCBIGene:760","sources":[{"id":"urn:uuid:edd09c38-57b3-4fde-bb82-d12e009e91de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10433","original_object":"UniProtKB:P00918"}
{"id":"7ae1fc66-abe0-43b8-8d7f-a518db7893cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:25505","sources":[{"id":"urn:uuid:898da0c4-c94d-4a2f-a553-a52d48b7333f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P47824"}
{"id":"5c697332-1601-45ba-b177-733e2ac05eab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177607","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:59f12928-a3e2-450f-b70a-cba273add1cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9231","original_object":"UniProtKB:P34972"}
{"id":"6b92bef9-9f16-40df-b708-571cbe860ebd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44566108","predicate":"biolink:affects","object":"NCBIGene:20181","sources":[{"id":"urn:uuid:50f268ae-8443-4439-8e33-f0c49ec91306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2816","original_object":"UniProtKB:P28700"}
{"id":"81366db3-87a4-4eb7-872d-6e715908086b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118701008","predicate":"biolink:affects","object":"NCBIGene:50488","sources":[{"id":"urn:uuid:28a5ebca-b6b1-4044-975a-eb0c39984a3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13265","original_object":"UniProtKB:Q8N4C8"}
{"id":"68538f3c-4562-4aaf-bc79-982c1c141292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:68667","sources":[{"id":"urn:uuid:cfb154b0-fefc-4582-a6ed-3120516899ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q7TN37"}
{"id":"fe8a742e-b7bf-41be-8683-e812a733dbf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:0daf1256-e21b-4156-9364-fb6b3dff9b37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P28223"}
{"id":"bf9c1e68-da61-4945-940f-5faf3bc4c5d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27690","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:84751741-4032-4866-a3ef-14e47934968b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6792","original_object":"UniProtKB:Q9ULX7"}
{"id":"9b30b032-6114-4514-993d-79354e29f749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:0081888f-b8fd-4331-9e9f-493dc599ebd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:P04775"}
{"id":"07d57e9f-a9b5-433d-9923-cad6a8382746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23056","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:0ce16c09-f89a-4488-84ed-05dbeea51849","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3260","original_object":"UniProtKB:P08173"}
{"id":"d95758eb-4c61-4f0f-83d1-15c3a51933e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134324842","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:ed435223-c8d1-4d5f-8d2f-d555e7481800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10417","original_object":"UniProtKB:P51679"}
{"id":"65924478-2643-40b8-b007-e59d2da6ef90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172573","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:849d451e-4e53-4ed7-b628-ed24ec336ca2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1771","original_object":"UniProtKB:Q9H244"}
{"id":"f7c8a9da-59ac-43be-9dda-866029bf8e20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138179","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:1aa37395-42e3-4c4a-bf36-8d5726671ae8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6239","original_object":"UniProtKB:P25090"}
{"id":"b8d1271a-4cfd-4e94-bb29-8e558f992db6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:200576","sources":[{"id":"urn:uuid:1331abc0-bec4-4d9d-809e-90883572fb64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q9Y2I7"}
{"id":"8d8f4c9a-4358-4ee4-a651-e63615b6113e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PQX0D8J21J","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:8d638cca-f078-49d6-a7e7-961a6cf8c6a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6882","original_object":"UniProtKB:P00533"}
{"id":"b4e2b66a-ce68-4639-8060-1b1dddbccb78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CJN36EQM0H","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:8c517e42-abc5-4a4c-9e40-6cc9d77d53cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9662","original_object":"UniProtKB:P00533"}
{"id":"abb9f376-6abd-419b-a340-02a7565c2a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:110b300a-82a7-4149-b774-4e9d28426ff5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P21918"}
{"id":"bacd8cf0-3635-48f5-a1c6-a1b4eeda02ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:e045b7fc-57e8-4f58-9568-69c73ebebc09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P0DMS8"}
{"id":"a9946059-e354-416e-b6de-96c61d7a8738","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:2846","sources":[{"id":"urn:uuid:dc862d4a-d66f-46e8-8c8d-f04436c4c076","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q99677"}
{"id":"ae80dcb0-e9d3-45f7-b740-447909056d13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4060","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:67ea7f25-0409-4f53-8e77-889ab307029d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4060","original_object":"UniProtKB:P41143"}
{"id":"0851707a-d737-41ce-8fb6-07393c35db0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:39IS23Q1EW","predicate":"biolink:affects","object":"NCBIGene:978","sources":[{"id":"urn:uuid:18879398-e488-4b2c-b083-b7fd41e435c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11101","original_object":"UniProtKB:P32320"}
{"id":"b7b79672-dda4-4572-8578-13b6ae830c89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44208891","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:fc65453d-b2b6-4f83-b3d2-c3566d22781b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1348","original_object":"UniProtKB:P49286"}
{"id":"cc6018c3-adbf-4c24-9296-31a170076ba9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:156","sources":[{"id":"urn:uuid:0ca7d29f-a4bf-4ecb-a101-ce86001b7e52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P25098"}
{"id":"3a820e27-064e-40cb-91a3-953d3217cb84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1321","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:b5e34c69-4b43-4df9-9764-3c9fb72e0158","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1321","original_object":"UniProtKB:Q01726"}
{"id":"2e9c6326-98eb-4fce-9b8b-f6dafd195557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:96711H97SD","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:3dffeb59-eb81-4ce1-8809-ec9ae6547c22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2165","original_object":"UniProtKB:P49684"}
{"id":"b0730a03-538e-4601-9363-10ffc2956db6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51003564","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:d4dd89b1-0fd3-452d-9491-dac07212c87e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6406","original_object":"UniProtKB:P41594"}
{"id":"4bb9de95-74a0-4d0f-9361-f80d0b76f447","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8313","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:b6e8711c-31a8-4e11-8765-fb6b0ecb2342","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8313","original_object":"UniProtKB:P09874"}
{"id":"9ab81b7b-bd71-4c34-8378-7218d5ef81f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190931","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:278dd2f0-3c11-48b0-a2ad-5ecf5d6b591f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10734","original_object":"UniProtKB:O75469"}
{"id":"d635a298-6afe-4679-8d5f-cda74f3710f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801163","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:c7ec003b-38cc-478a-85f1-34e6bfba3bf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9712","original_object":"UniProtKB:P09619"}
{"id":"7bca448e-f171-4359-8292-a16af7f3baa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DB1041CXDG","predicate":"biolink:affects","object":"NCBIGene:608","sources":[{"id":"urn:uuid:4bcef5b2-d96b-4fca-945c-3926e2c14b0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11117","original_object":"UniProtKB:Q02223"}
{"id":"719e258a-0713-4bce-998a-8d03126d1dcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:b1ff1e93-4359-40c0-8313-94dd33224e8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P11362"}
{"id":"dd882e99-dd95-4896-a9a2-237a62105b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5068295","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:8b868ed6-7131-4c95-ba5e-558ca3c2c013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4295","original_object":"UniProtKB:Q9EPK8"}
{"id":"5085c26e-d078-418c-926a-e2e418739a74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23815478","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:295db028-3c22-47a8-81bf-dc32774be188","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:64","original_object":"UniProtKB:P08908"}
{"id":"608f2060-8602-405e-a40a-cd3e8389f050","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL69234","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:51c17cdb-9178-4a91-9daa-a50a0604fed9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1725","original_object":"UniProtKB:Q99571"}
{"id":"5b3e78b5-b6fe-4713-a90d-ddf119ed5194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73688","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:b1194263-ca0a-47b3-8ddc-ef7f4abeb5f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1405","original_object":"UniProtKB:Q14832"}
{"id":"04b000b2-1957-4260-aa07-486cab292451","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:353174","sources":[{"id":"urn:uuid:296b104e-3be9-4780-a50c-1b793972d880","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:Q401N2"}
{"id":"0dfe64ab-c397-414e-8888-3f68a9cdcfba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138424","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:088d8c73-0474-4ae4-84af-533e04dd40f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2508","original_object":"UniProtKB:Q9UL62"}
{"id":"a0ea0917-44b4-46be-9aee-39ba7d68fa54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138670561","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:c18174da-45c4-4401-8686-e1bd75253f6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12017","original_object":"UniProtKB:P35408"}
{"id":"4475394a-e853-4f7b-b813-61b953cb518b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155195529","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:dc2ce661-e09c-4d30-aca2-d12716ce540d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11747","original_object":"UniProtKB:P09619"}
{"id":"3e858e8c-4b9a-41f5-aa47-f7132c6d3c6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5282428","predicate":"biolink:affects","object":"NCBIGene:292661","sources":[{"id":"urn:uuid:2e72c081-4537-4c09-8a1f-ade9ab67e736","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1967","original_object":"UniProtKB:P43253"}
{"id":"f07dfbb3-6c53-460f-9b70-5ed3e9da672b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17303","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:857306f8-2e12-4fa5-8d65-6b7993cca5ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1627","original_object":"UniProtKB:P33535"}
{"id":"018bc2d2-0cc3-4b9d-940c-33102f66380a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197431","predicate":"biolink:affects","object":"NCBIGene:2899","sources":[{"id":"urn:uuid:13f3bd36-e3d7-4aa9-9197-796a32397cd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4185","original_object":"UniProtKB:Q13003"}
{"id":"9aa573ad-4fdf-41ca-a6db-f2d0dc19e4ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52943938","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:c406e7bd-84a1-483d-ae7e-0fc71af49f52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3947","original_object":"UniProtKB:P41180"}
{"id":"24a8acff-2497-4636-a3ce-34b56f87e6ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755035","predicate":"biolink:affects","object":"NCBIGene:25323","sources":[{"id":"urn:uuid:69a6e621-c181-4737-a1c0-40b9898c5d86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3250","original_object":"UniProtKB:P28565"}
{"id":"7bf66775-2e97-487d-9fa2-2746e0c3a5f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4329839","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:dcc6fb0e-eb3c-4a11-a6e0-384701c6d147","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:861","original_object":"UniProtKB:P32239"}
{"id":"7b922228-bd2e-464b-9337-63350b454df6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8VK61D7U5D","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:3c50ec83-12a9-4d20-b7d6-3e3491944b5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10696","original_object":"UniProtKB:P41180"}
{"id":"2fd7ef02-0bf5-47ed-a595-c71330ab42b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2B218X5QIY","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:46dab7b9-08f0-45e4-a75f-92041410333d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7697","original_object":"UniProtKB:P36544"}
{"id":"5efb36a3-3311-40a7-aacf-ce2abd3fae67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4358","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:f1336e43-1a9e-4186-878c-4381704b5386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4358","original_object":"UniProtKB:P61073"}
{"id":"aa3e22ba-3cb9-4a1c-b820-02f3565ec0fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2062","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:8ac770cf-1dea-469b-b40f-b51023f966b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2062","original_object":"UniProtKB:P30874"}
{"id":"ed974ec0-4288-47f5-9d7f-5b0fbeb1e9d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4866","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:014de39d-b3a9-49e2-8a99-de34f3e5d575","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4866","original_object":"UniProtKB:P16066"}
{"id":"883b0917-fdd2-42f2-a2dc-ce53c0e4279f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321937","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:4be2732d-c059-4745-8586-3f0e8a4ada9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3979","original_object":"UniProtKB:P43681"}
{"id":"179f23d6-11fa-4664-9bc5-be21e7d242f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3985","predicate":"biolink:affects","object":"NCBIGene:8973","sources":[{"id":"urn:uuid:38156a45-9eb8-4991-a9cf-3d3abb80dd70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3985","original_object":"UniProtKB:Q15825"}
{"id":"8d99d59e-e7bf-4e6b-a4ee-da83bca5d127","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118893637","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:04fcb17e-55ee-47fc-95ef-71e3285beaa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13218","original_object":"UniProtKB:P22607"}
{"id":"fa6d9ca2-e242-48b0-8e34-179e3096914e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135348858","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:111c907e-a731-4759-a308-8f3f2d8d4555","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10490","original_object":"UniProtKB:Q9UQL6"}
{"id":"9ad07f9c-e9f5-44c7-b282-b740b32e6eb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:9ab33e7e-a252-42bd-a725-fdc4bcb9f5f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P30939"}
{"id":"cd6caacf-3f7e-44c7-ba2a-a015a56752f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135903","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:bbb0a1de-ead5-47a6-9052-d6f6a5adf25b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2086","original_object":"UniProtKB:P29371"}
{"id":"87bc49e3-4806-4403-a23e-65fc3c63012f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311462","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:535c68ff-e945-4ce2-af82-22a766b250cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3344","original_object":"UniProtKB:P41594"}
{"id":"5eed4b48-7033-434a-8a94-36dc330079d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167729","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:0ab02c5e-a78c-451d-aaa1-f026b43a3f66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2506","original_object":"UniProtKB:O14649"}
{"id":"8111c506-9511-480b-9ffb-c9aa64b62992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10358175","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:819a7c42-a66b-4f5d-b581-21c4e196d5a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3100","original_object":"UniProtKB:Q02769"}
{"id":"097bfa69-061b-4f8e-8e0a-5f938bf06544","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46226294","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:39d72147-7bd5-4e7d-a47a-4b0cd2881525","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12861","original_object":"UniProtKB:O15552"}
{"id":"67229c7f-07c9-4346-8709-7983053a845d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827360","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:0f930fc0-aabd-4482-823d-a87146884250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8422","original_object":"UniProtKB:P30939"}
{"id":"56794952-0a15-4659-af30-e42d57d66bef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RSH7NDI7MI","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:2505d59f-cbf9-48e4-886d-dbc96b3aabcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5759","original_object":"UniProtKB:P25103"}
{"id":"31f4931f-950d-4cad-827e-db7a28c79482","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2235","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:e16a233b-f9f7-4f80-b533-ba22840618e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2235","original_object":"UniProtKB:Q00788"}
{"id":"30f2c111-f944-4915-bece-be4aead31d1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154617563","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:aae1244b-8e4e-4903-a52e-5dec6131ee75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13513","original_object":"UniProtKB:O43613"}
{"id":"616e558a-e40e-4732-861c-3b2636b0d175","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:e081f252-77bd-411d-a3cf-2d961e4d166a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30680"}
{"id":"cce0fe51-b3d2-4928-a232-6d96f50c699c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34727","predicate":"biolink:affects","object":"NCBIGene:2901","sources":[{"id":"urn:uuid:64f6ca91-046b-4051-9603-7ba1ae245fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4181","original_object":"UniProtKB:Q16478"}
{"id":"98e9f548-f16a-46ba-9fc8-118252e15770","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92596","predicate":"biolink:affects","object":"NCBIGene:2563","sources":[{"id":"urn:uuid:a19bc1df-cf44-4dfe-8962-5788677b8bd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5467","original_object":"UniProtKB:O14764"}
{"id":"d2c7dee2-f5c3-4773-8228-e36acf1dbf79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9806449","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:80b99be4-8877-4070-be9c-3e6df0ad4844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1355","original_object":"UniProtKB:P48039"}
{"id":"1f8f895b-b997-4093-bb83-c223cef1202b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3699","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:ba5cc109-d767-4c6c-9f68-2e02a309428a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1231","original_object":"UniProtKB:P25021"}
{"id":"ae94fb75-9d23-4c10-a8b2-91385eccaaa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11994411","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:35a67b0a-15dd-4893-b5fe-9bcdcc33fd97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1306","original_object":"UniProtKB:Q99705"}
{"id":"d449d8f5-e741-47bd-8005-63da97f6e287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132233","predicate":"biolink:affects","object":"NCBIGene:763","sources":[{"id":"urn:uuid:b1b3d1c4-1420-4f95-a3e0-7e65ca2afd34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4804","original_object":"UniProtKB:P35218"}
{"id":"2638e9b3-941c-4f6a-8d11-c3cd8b7c3c4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2709","sources":[{"id":"urn:uuid:9b6ccb3b-cef2-474e-b820-fd2ea515e52b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:O95377"}
{"id":"3d3e1e7e-a360-4957-9ee5-7aedf496a204","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94409","predicate":"biolink:affects","object":"NCBIGene:70456","sources":[{"id":"urn:uuid:5e954698-d50e-404b-98c9-b40dbe977483","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11303","original_object":"UniProtKB:Q9D023"}
{"id":"1e131c12-5fcc-41f9-a1f0-729c5185001b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22991950","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:2a4d249b-68b2-426d-8a8e-c3255d888c14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:326","original_object":"UniProtKB:P08173"}
{"id":"906571cb-86f8-427e-8907-ca3e299772e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92070","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:58ad893f-bd6d-4b1b-8fd6-b9e8a5641716","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:94","original_object":"UniProtKB:P08908"}
{"id":"bd129f82-3e24-47ca-b2a0-3949263d8c16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95083","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:184c54ef-9eb9-4580-8407-9db1ca02c5d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7518","original_object":"UniProtKB:P25440"}
{"id":"aad091c2-7fb7-4fe3-be72-014641f7c2eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17418","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:570a0a30-cb7d-46f5-9762-c7346454844c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1061","original_object":"UniProtKB:O15552"}
{"id":"8bfb10a0-dd4f-423b-a209-f448e48a8bf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6715","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:fbb745bc-c4b5-497b-8b1c-c29dc2c7c7d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2879","original_object":"UniProtKB:P06401"}
{"id":"83b58b5c-5ce1-4a89-a928-64e9e9309aab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17574","predicate":"biolink:affects","object":"NCBIGene:2101","sources":[{"id":"urn:uuid:f9e94337-7f74-4825-8bf1-986035e03ec0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2829","original_object":"UniProtKB:P11474"}
{"id":"0b95b3bc-2d7d-4d6a-8dc0-969da06a05b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4852","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:9a6d4413-8fd9-47c1-aa74-57cae8b93c3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4852","original_object":"UniProtKB:P16066"}
{"id":"b3d33005-60d0-4c32-8be7-93f9c2cc057f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:bd732d6b-d5ab-4018-b691-75d907d56255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:P48736"}
{"id":"dbe23009-be97-4fd9-9176-7a4550783487","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165437860","predicate":"biolink:affects","object":"NCBIGene:55611","sources":[{"id":"urn:uuid:a108f672-e176-4c37-bc20-3a9e6f40b977","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12224","original_object":"UniProtKB:Q96FW1"}
{"id":"295c4dfc-414d-44a6-9e27-fce46cdbd16a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2000","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:bdd58e3b-9d53-409e-a63c-3a7c0fac7c07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2000","original_object":"UniProtKB:Q8TDU9"}
{"id":"0312b636-bcc4-46ce-af3f-bce58f3bcdbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:186187","predicate":"biolink:affects","object":"NCBIGene:14080","sources":[{"id":"urn:uuid:64c01eea-e210-4b0f-a2ba-4e78006a281e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6736","original_object":"UniProtKB:P12710"}
{"id":"818de9f3-d330-487b-9b4b-f7fc6756de9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2221","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:98b69ad4-651d-4fc8-b875-093dfb571430","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2221","original_object":"UniProtKB:P30518"}
{"id":"4855a90d-5760-493f-8b85-d41b16ef0000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5869","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:ce351ae2-49b3-4a69-a2da-22b75d727ec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5869","original_object":"UniProtKB:Q92847"}
{"id":"ea4b381b-578e-4616-864e-545607ed4cca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3946","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:bd030a1f-f810-4a5a-a640-42eff9329c42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3946","original_object":"UniProtKB:P32247"}
{"id":"4d8c67d8-4bb9-4b31-89a4-61df31328dfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66910","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:eeb62025-20a7-4322-b1ef-34095d63ae1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5659","original_object":"UniProtKB:P35968"}
{"id":"227783a1-b111-478c-b6fa-fa8155d584bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16893","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:dfc30cdb-733b-4df6-bdab-8e6dc29a8e4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2921","original_object":"UniProtKB:O95977"}
{"id":"5ae14f8c-39fa-45d4-b56a-64a423aae7f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47519","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:9ef42760-d146-40be-8cf1-da42a036b268","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2568","original_object":"UniProtKB:Q16322"}
{"id":"a6f1447e-da73-4477-a234-56e25b722ebf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11998180","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:c44bee64-b490-4b08-8d30-38d35122250d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3993","original_object":"UniProtKB:P43681"}
{"id":"3be82e62-f77e-43e2-b9b9-072f1ad7bb2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:5450e520-2d8c-452e-a207-a9fd43990215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:P10721"}
{"id":"0f867233-eda6-43b9-a06a-704cd22f8c0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2663","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:523d6e65-0f71-48f5-b333-e2f7efa84e6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2566","original_object":"UniProtKB:P08912"}
{"id":"49b9fef3-56d5-4aff-a03b-918420bb3dff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PX9FTM69BF","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:efe718fe-eb6a-4b6d-8344-098414bd981b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11190","original_object":"UniProtKB:P07333"}
{"id":"bd19d3b6-c9b4-4df6-98a9-5f8f66be8bc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:9e982932-57f4-429a-8e7c-999a7c85f827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P50406"}
{"id":"cd54c78d-8ccc-4a38-b37f-129f37b4a940","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5017","predicate":"biolink:affects","object":"NCBIGene:6560","sources":[{"id":"urn:uuid:b743646f-3368-41ea-83c2-a27235d56227","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4589","original_object":"UniProtKB:Q9UP95"}
{"id":"19e12e36-fdb6-4096-ad54-ea65d1d4a8f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5084","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:f8ad656c-b795-4e3e-9139-4b8266e521cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5084","original_object":"UniProtKB:P25092"}
{"id":"17bd3605-f41c-4dbc-826b-d75d16a2bf58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:116098","predicate":"biolink:affects","object":"NCBIGene:166929","sources":[{"id":"urn:uuid:ddaf8b0d-c6d4-44e5-95ef-2a431eca0bec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8834","original_object":"UniProtKB:Q8NHU3"}
{"id":"d3ed5f89-8f14-4eb0-b4fb-615792a05388","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71662429","predicate":"biolink:affects","object":"NCBIGene:1544","sources":[{"id":"urn:uuid:1200962c-788e-4597-854c-7412ffd26431","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8748","original_object":"UniProtKB:P05177"}
{"id":"e4241d7a-a093-407c-8e71-6725e280a5b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801164","predicate":"biolink:affects","object":"NCBIGene:2826","sources":[{"id":"urn:uuid:0a3f40bb-055c-420b-8352-21a0f7c7712a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9714","original_object":"UniProtKB:P46092"}
{"id":"2977aa53-e7b3-47cd-ba27-a5ee04d4be53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1787","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:88955c55-7496-4818-9693-71b4542be77a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1787","original_object":"UniProtKB:Q03431"}
{"id":"eab52106-217d-4eb2-b0dd-5af9c206fcb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91826710","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:21c770cc-b4be-4315-9b1e-53af3527abc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10011","original_object":"UniProtKB:P25092"}
{"id":"44e9d6db-8cff-4829-8ac9-02b69cfd049b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92386","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:0b4857a6-d67f-4475-95ef-aab5460c1ec9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:523","original_object":"UniProtKB:P08913"}
{"id":"aead4e67-d175-4155-b9b9-496bdaecd0bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:114115","sources":[{"id":"urn:uuid:2326b021-c7ab-4bda-b53a-14fac6724a28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P49653"}
{"id":"361a02b2-234d-45eb-8856-75b9fea53f98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TWF0ML1CK8","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:66b5c83f-0e9e-4cda-8409-cadb31bc9604","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13763","original_object":"UniProtKB:P09874"}
{"id":"b2a7b9fd-c806-4eae-80f4-980ad9d8d198","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5183","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:57b77cea-c1c0-49e0-8edc-efa2e941e70d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5183","original_object":"UniProtKB:P09917"}
{"id":"017faec5-d0ff-4404-a843-d032e09d127e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95074","predicate":"biolink:affects","object":"NCBIGene:79813","sources":[{"id":"urn:uuid:ddd44aaf-70f9-43cd-b01c-d5b44699d0bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7015","original_object":"UniProtKB:Q9H9B1"}
{"id":"6ab1311c-b475-4b0f-a656-2b30375e90f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46232606","predicate":"biolink:affects","object":"NCBIGene:313","sources":[{"id":"urn:uuid:ed4d3413-fc64-468d-93ac-63c8eee37687","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8606","original_object":"UniProtKB:P28039"}
{"id":"e0db17af-7594-420e-b3ff-8a626debfc5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8332","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:82b620ea-d57f-4fb8-9104-452243c96f5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8332","original_object":"UniProtKB:Q8WXD0"}
{"id":"ff05cd60-38cf-4e18-aae5-93b72f77e9ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191049","predicate":"biolink:affects","object":"NCBIGene:29637","sources":[{"id":"urn:uuid:20f10deb-bd8a-465b-a786-e10a6477f6f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5886","original_object":"UniProtKB:P17425"}
{"id":"60a8a689-dcfc-4492-bc02-f0b8263ac028","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24916963","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:8e1f1403-9cd1-43d3-837b-731e10117319","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3006","original_object":"UniProtKB:P04035"}
{"id":"1fa78318-f8d6-453b-9c1e-178e7298c5f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:585bc2f0-722d-4f36-9d81-6cd4226f3922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P47898"}
{"id":"eaa4245d-1cf9-46ea-b098-1d84ca59320b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9927","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:fa8b5adc-f0ab-4c99-9275-f5d117c24952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:593","original_object":"UniProtKB:P30556"}
{"id":"42e8b92a-12d9-441b-a29d-1e7a0adfcc9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DWZ6SE1E1","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:8d9a31b7-9489-4199-9a50-b0a1389f4bd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11580","original_object":"UniProtKB:P00533"}
{"id":"15eba337-a099-4de8-a1a8-5ea3895cdfe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311268","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:9edab38a-0077-4228-bc54-0deb8680594a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6118","original_object":"UniProtKB:O08726"}
{"id":"782a1f2b-a7e9-4c3d-b49e-65a116688cf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91360","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:4febde3b-3b14-4268-894c-750f8f6d0050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9328","original_object":"UniProtKB:Q16539"}
{"id":"75d59f03-d04a-45fa-ba38-e8a6abde657f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75307","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:20cf6e77-12ac-4d75-998b-37abc7796cab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11393","original_object":"UniProtKB:P09917"}
{"id":"2906b274-9d22-442c-a7ec-aa7edbeed5f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36511","predicate":"biolink:affects","object":"NCBIGene:1186","sources":[{"id":"urn:uuid:3c13673b-7a55-4fd3-81cc-f28d12fb6d9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4177","original_object":"UniProtKB:P51798"}
{"id":"12afb812-5340-44d7-a452-2a6c923497ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:113995","sources":[{"id":"urn:uuid:887f7349-7a02-4c11-bd36-8e5bfb497892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P51578"}
{"id":"2746f840-4fc9-4b86-a405-feaff75a1838","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311423","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:f20a0d81-f101-4cda-a20d-6e3e8bebf401","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:257","original_object":"UniProtKB:Q13639"}
{"id":"39af4f65-0ef9-452b-80bd-03cbdd5fc3eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11418","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:5f092000-565b-4879-8837-81ede1da0285","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11418","original_object":"UniProtKB:O60755"}
{"id":"51176d19-b8a7-4b3e-b71f-990241c7549f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643953","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:1203173f-00b8-4be2-b155-b10a5069c155","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9751","original_object":"UniProtKB:Q13546"}
{"id":"320ca20d-d66e-4892-be12-f9a9d34d29bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46898088","predicate":"biolink:affects","object":"NCBIGene:81672","sources":[{"id":"urn:uuid:f929bcda-9a38-4bcc-af4a-d168a75d4b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6739","original_object":"UniProtKB:P35400"}
{"id":"00dba947-f23a-4bdf-836c-fb3100ab20c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90879","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:ced20a4d-4d18-453b-bdb2-34301e2f7bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8696","original_object":"UniProtKB:P0DTD1"}
{"id":"1e3d8c76-9d92-4e25-8f36-d8b034c46761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5527","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:c4960b77-d181-434f-a979-6b3695431eda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5527","original_object":"UniProtKB:Q99572"}
{"id":"2ef10cd1-8ad8-40fd-a17f-2f9b90bf049f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3780244","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:4522262c-f75f-475b-9a55-7597db01aaaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9314","original_object":"UniProtKB:Q92952"}
{"id":"6bac8a4a-0a7d-471b-a9fd-a4be790f7ac1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155437283","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:3be38907-ca55-4040-82aa-57fd9b80d136","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13341","original_object":"UniProtKB:Q9NWZ3"}
{"id":"9f018b80-2eef-478a-a976-dbd547e32d28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:516ecd02-aa69-46d5-b991-2cd21acbaa4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2491","original_object":"UniProtKB:P16388"}
{"id":"57e825c0-4ee9-4966-af51-d874cfa04dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65353","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:4f680768-e1a9-4508-a851-81b172aa0938","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2941","original_object":"UniProtKB:P28335"}
{"id":"f6f60b80-8ef7-4483-b7e8-55a51f2ffa39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94686","predicate":"biolink:affects","object":"NCBIGene:26090","sources":[{"id":"urn:uuid:ad8238e7-111b-4bc1-83b2-16502f5d3412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5277","original_object":"UniProtKB:Q8N2K0"}
{"id":"68a55abe-38ab-4c09-a826-b5334a4b477d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7939","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:93fac764-dc21-4064-9cab-9873b17ae08c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12428","original_object":"UniProtKB:Q9NYW2"}
{"id":"7cfabf00-eafd-4aa9-bd17-226bb5038c76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5HNG5UF2U","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:efdc5411-88ea-4fab-b930-4ff739ebdffb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11885","original_object":"UniProtKB:Q00534"}
{"id":"0822b0a3-551f-40e5-ae4a-cdd5ab5c08f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:eeb6edcf-da48-4d87-b569-fe6d4c9d3bc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P19020"}
{"id":"844aed4d-98d3-4365-a6b8-4e48dd0e3755","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310983","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:a089a7b5-08a5-4990-b19d-f7e3d6e41039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1711","original_object":"UniProtKB:Q96G91"}
{"id":"9acf985c-32f4-4d10-89ce-598a231b08ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:a3f9dfa8-e531-412a-8b81-d7887ed0a61f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q9UBN7"}
{"id":"e708552d-26e7-4193-98e6-a80fd54216f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13547416","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:5569eb13-5b3a-46d5-9c36-9bc2298623d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:169","original_object":"UniProtKB:P28335"}
{"id":"4c99bf31-f85a-4781-93be-13af350ffd90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311330","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:0de75370-00e1-4000-9274-9b0a56ae6579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4271","original_object":"UniProtKB:P13569"}
{"id":"b5ccf07c-b759-47fa-98f9-257fb7631054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:792b0589-e8fd-48b7-b3ea-af1c4cf45f24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P30680"}
{"id":"b3f7638d-1278-4d8e-83c5-c5952bdfea65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1292","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:29a4287a-e5ca-4c88-b585-731d968d34a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1292","original_object":"UniProtKB:Q99705"}
{"id":"8fccea97-0299-4c5d-b9fd-31ca411fe08a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3972752","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:8ff791b7-8099-40f4-9bc2-0d8e2a796f5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1415","original_object":"UniProtKB:P31423"}
{"id":"7e81541d-75f7-48d3-8045-ef3fd9d9cab6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3740","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:7ced4f09-ea03-4655-ad2e-9c9dae8509bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3740","original_object":"UniProtKB:P55085"}
{"id":"041f14b8-ca2b-4ced-8c03-6e0b292a2ed4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:339a95d7-8f57-4be1-b721-937034e5ea60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P51813"}
{"id":"e23d25b8-bc59-4e8e-91a3-4f6be1f6aeb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9858913","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:78c16bb4-dd82-4834-bc4a-f3cb9888ec3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13505","original_object":"UniProtKB:P35354"}
{"id":"8e189b99-6af0-4f34-b647-649e1bd56170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81390","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:a3eac451-16df-408c-8f56-8d8cd5e420f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1251","original_object":"UniProtKB:P58406"}
{"id":"600d0aef-9778-4e75-a85b-3193b4c9bb2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86292328","predicate":"biolink:affects","object":"NCBIGene:6778","sources":[{"id":"urn:uuid:daaa92eb-164d-460c-9dbf-633afd370c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9842","original_object":"UniProtKB:P42226"}
{"id":"537c6fb1-93d5-486b-b63f-fb6e80dd59ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:7ff1d64a-d2fc-4548-be2b-95a71e14410f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P07333"}
{"id":"e7d2302b-4153-4c48-a889-01aba1312622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4008","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:2c43ed18-fdb6-4258-ab5b-c4574cfe3393","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4008","original_object":"UniProtKB:Q9GZZ6"}
{"id":"12ed18e5-ab28-4a55-bc6d-70aebae181d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946746","predicate":"biolink:affects","object":"NCBIGene:4837","sources":[{"id":"urn:uuid:2905890b-4c60-4d61-8cb3-12b1e31dd557","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12166","original_object":"UniProtKB:P40261"}
{"id":"a2f24333-12fe-4ef3-9113-2419b531c053","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X4D0G881CN","predicate":"biolink:affects","object":"NCBIGene:1118","sources":[{"id":"urn:uuid:706dd6cd-4712-4a67-8c5a-1371e8a27f28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11617","original_object":"UniProtKB:Q13231"}
{"id":"7c72855d-28a2-497a-9e71-0f538a363484","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24825775","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:6d38d8c1-24fb-4a9c-88c5-a6f7820193d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3929","original_object":"UniProtKB:P34969"}
{"id":"b1757688-e81f-459f-9ce1-90e15a402c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2NL79NI1WS","predicate":"biolink:affects","object":"NCBIGene:1595","sources":[{"id":"urn:uuid:d21b50d4-e5b9-4b88-9397-055d2d54dbb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8799","original_object":"UniProtKB:Q16850"}
{"id":"59cd7dc1-1941-487f-a428-ed3adf1936a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135355941","predicate":"biolink:affects","object":"NCBIGene:7075","sources":[{"id":"urn:uuid:668a03a1-2a20-47f4-9eb2-69482bdc71d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11791","original_object":"UniProtKB:P35590"}
{"id":"1cf5fc74-5a3b-47d3-8e8c-9e50170d351a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:87ddd271-f52a-4f93-8ed4-d89ef49c64c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P13945"}
{"id":"15ac9ea4-7108-47f8-9b2b-d40bbb131db5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29009","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:7705193c-7248-4787-91f9-f55c598c484b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1242","original_object":"UniProtKB:Q9H3N8"}
{"id":"edd2f076-5a80-47c2-a219-047eb333424a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131166","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:ba50f2cb-de02-461e-83af-0814413d49ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8003","original_object":"UniProtKB:P42345"}
{"id":"30d4dd2a-c1d1-4ffb-bffe-297cc31a4145","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:ca921213-2570-4fbb-b2d7-2c713a0ab390","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q9UKV0"}
{"id":"eba56b77-9a5e-4ded-884b-d746d788e251","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4284209","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:0fc149be-27ae-4cb9-af79-45ec5f0c55b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10081","original_object":"UniProtKB:P24941"}
{"id":"cc5d3f66-2f63-42af-9a9f-12e8eae2e0c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081973","predicate":"biolink:affects","object":"NCBIGene:79400","sources":[{"id":"urn:uuid:ce3c6063-3b28-42ab-9b68-f30f056f29b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9933","original_object":"UniProtKB:Q96PH1"}
{"id":"6ccc2746-0fc7-44b2-8794-cba7fe785a58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:4294","sources":[{"id":"urn:uuid:740fd6e2-4e4f-4353-8f79-a1125cea83e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:Q02779"}
{"id":"8e5ab1aa-cc91-4f27-9e3d-07f6597a1629","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56847486","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:3558184f-eed7-4b94-a27e-4d23901c87fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8247","original_object":"UniProtKB:Q12866"}
{"id":"d73314c2-9e7f-44cf-be2d-76c7ac831d9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1700","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:24e4ed0e-6429-4920-8fd3-18bf747a9e4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1700","original_object":"UniProtKB:O43613"}
{"id":"d4431183-b2c1-4794-bb09-63aebaa0f0b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82813","predicate":"biolink:affects","object":"UniProtKB:Q9JIS7","sources":[{"id":"urn:uuid:c265776b-d001-492e-97a2-a0f7534c42bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2349","original_object":"UniProtKB:Q9JIS7"}
{"id":"59a3045a-f4bb-47d8-b29c-44da63f289bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:742QGP819Q","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:1f712bda-34d7-4fb5-943f-723f17af1d0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1849","original_object":"UniProtKB:P25105"}
{"id":"34cf3b45-3c07-405f-9f82-616b0200969d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:5a51e66d-d340-4960-920e-a20771e827a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P51451"}
{"id":"8c0feb62-4a20-49c6-a464-7fd815fc2d4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486355","predicate":"biolink:affects","object":"NCBIGene:5046","sources":[{"id":"urn:uuid:107a7f24-7754-47e8-af2b-2eab6ba12ae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6564","original_object":"UniProtKB:P29122"}
{"id":"66a68888-5542-4064-82c7-07af67bbdb5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2534","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:3ed935d6-7ec9-4299-b985-0819b31af15f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2534","original_object":"UniProtKB:Q02294"}
{"id":"62ecdc7e-fac3-4cc5-8e86-89718ed4e751","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030526","predicate":"biolink:affects","object":"NCBIGene:29028","sources":[{"id":"urn:uuid:61806849-f9a9-4506-af3f-5e01021d6789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10445","original_object":"UniProtKB:Q6PL18"}
{"id":"81e0df00-e551-4a24-a79c-353e42942132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:86066163-b17c-45ce-837b-d0c2a1e22c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:Q9UBN7"}
{"id":"7fee0a6b-4889-47d5-ad34-60307ef919b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50692","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:da97c71d-556b-4646-b452-1a6112594c93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2805","original_object":"UniProtKB:O75469"}
{"id":"d1d665d2-4550-4eb5-b259-bd59903f7202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:9995a521-330e-4e9a-b375-921c28d7c027","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:83","original_object":"UniProtKB:Q9UL62"}
{"id":"98bb9c6c-1df2-41ee-867c-5d32ae98d2a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118694559","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:f23fa36b-a5a9-4e5a-afe0-e2d2e57c27f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12906","original_object":"UniProtKB:Q8TDU6"}
{"id":"e85b21eb-b8c4-46b9-b6fd-e57932abc80f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50122","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:c93fd3a6-0985-41a3-b987-16743ecb12e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1056","original_object":"UniProtKB:P37231"}
{"id":"b6d687c0-372f-4884-9c0a-cf29b1fda5e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8805","predicate":"biolink:affects","object":"NCBIGene:6833","sources":[{"id":"urn:uuid:b9356120-733f-4cab-90b0-ec6f2a5c54e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6841","original_object":"UniProtKB:Q09428"}
{"id":"048de76b-d2fb-4e9f-8262-855082be7ef1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918649","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:6d55263c-dfb1-4f26-8bc7-7252f677fb2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3241","original_object":"UniProtKB:P50406"}
{"id":"d7944a78-b055-47f9-8456-3649e25acdc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:2d327935-be0f-40b7-9804-049ff06f6794","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:P25100"}
{"id":"77ab0e8a-4942-4056-afbb-374e2aa0381f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25124566","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:275642be-2670-4ef2-87f0-6aa5eebe3123","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5870","original_object":"UniProtKB:Q92847"}
{"id":"e37f95ce-0b7e-4082-887e-716bf9daafa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:e26ebd88-e631-4b7c-945a-d479041d29cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P30939"}
{"id":"67f0dfbe-fa72-46f9-871d-62ae7721ccd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:abea6ef0-c055-4723-b597-64e217c2daf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:P35523"}
{"id":"8809bbee-e457-4c98-9311-596f25e9f00f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232894","predicate":"biolink:affects","object":"NCBIGene:255231","sources":[{"id":"urn:uuid:89df1c29-18c6-4f68-a112-ae27c3c765ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6386","original_object":"UniProtKB:Q8IZK6"}
{"id":"1722ccc4-c0f3-4c41-ab98-541ea931e9a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P0GMS9N47Q","predicate":"biolink:affects","object":"NCBIGene:841","sources":[{"id":"urn:uuid:1b59c4ed-6e90-417d-acab-d1f0a5c5bf91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6508","original_object":"UniProtKB:Q14790"}
{"id":"8c761fe3-da4c-4005-a964-60aade92c4b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2814","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:69601c41-aa81-4e68-a8fd-90f5162c131b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:296","original_object":"UniProtKB:P20309"}
{"id":"60f42280-9da9-4fdb-abb4-8508e24f8890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:631105","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:2708b334-acc3-4703-8b84-e56dbc55e812","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:401","original_object":"UniProtKB:P29274"}
{"id":"6197eb0a-b475-43b9-a3d5-e0b12e265c63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5697","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:467300ef-7e6c-45c7-ae6f-265132ca8661","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:404","original_object":"UniProtKB:P30542"}
{"id":"abf67120-dde8-4c6c-abf3-387771baa7bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:79O7855J4G","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:5b6d5b75-b853-4489-bebe-e6d32cabc933","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9875","original_object":"UniProtKB:P43088"}
{"id":"770777b5-35c9-4a8a-997b-c3565d5da690","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4284209","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:48df5b5d-1dc9-4eac-8881-7f9d5d1c62fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10081","original_object":"UniProtKB:P50750"}
{"id":"e352377a-c160-4a96-87dc-567a84a317f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24794417","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:fdd53943-4618-4189-9d5f-4e3476bf0aa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4168","original_object":"UniProtKB:O15399"}
{"id":"5223b9d5-0a2c-4774-b497-4536d28c1dae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431484","predicate":"biolink:affects","object":"NCBIGene:13850","sources":[{"id":"urn:uuid:e717cab6-8053-4b14-8c2b-17f036dc3497","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10124","original_object":"UniProtKB:P34914"}
{"id":"36190dc5-5015-48c6-b025-d86e06ccb3e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10197","predicate":"biolink:affects","object":"NCBIGene:2535","sources":[{"id":"urn:uuid:d8f5be25-bb10-46c7-929d-c94e14bcd4dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10197","original_object":"UniProtKB:Q14332"}
{"id":"f48502dd-52f3-436e-a1de-a3086db09743","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70707","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:88a65925-032c-476b-8f81-b35842167e0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7427","original_object":"UniProtKB:P35367"}
{"id":"ef53cbcb-27c2-4ff4-8e73-866965bbbcd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173077","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:5fa42a40-c11b-45ce-8a8a-96492d7f2874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7875","original_object":"UniProtKB:P42338"}
{"id":"38e74d05-f705-4589-b06b-68dbda07c975","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311502","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:e083b451-42ca-4f66-9653-b8fcc83a280f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4344","original_object":"UniProtKB:Q14643"}
{"id":"0d4e3de9-f289-4955-bced-3aa91318ca43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:295ba9c2-03fe-43be-bd5e-909c61553856","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:Q9UBN7"}
{"id":"fa09c91c-4cc0-4389-8d96-f35db209ebe6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YO3O4Q2NC8","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:2b0d5d26-1716-4359-9d81-7bdcd68475a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10053","original_object":"UniProtKB:P05164"}
{"id":"dee1104b-0e38-4564-8d80-971afe00ffcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50692","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:dd006a3d-dac8-4eb8-a938-9cd92f7eed70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2805","original_object":"UniProtKB:P10275"}
{"id":"63f16e0f-9f5a-412c-9f29-c04153486cd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1511","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:4017b437-b489-4935-a241-38c013bf6522","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1511","original_object":"UniProtKB:P50391"}
{"id":"250c9c60-b833-451e-9f39-3d65e0021746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1369939","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:a5eb6c62-f7aa-4f53-a05b-099ffde01d0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11539","original_object":"UniProtKB:Q8NBP7"}
{"id":"549ad848-a7fd-4e74-9575-01f2bacb88a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131839646","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:02e76db3-0008-4136-beaf-a14e824285d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12237","original_object":"UniProtKB:Q16288"}
{"id":"bee86e8e-cb17-4d2d-8096-6049d4cba7e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139443232","predicate":"biolink:affects","object":"NCBIGene:55902","sources":[{"id":"urn:uuid:0eb487cf-cc6c-4a3a-92aa-49dd1419f25d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11067","original_object":"UniProtKB:Q9NR19"}
{"id":"5315aa70-758a-403e-a362-2e4cffae0ca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4650","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:9e7c70a1-8304-483d-a940-132aeae559d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1617","original_object":"UniProtKB:P35372"}
{"id":"0f1b8f9e-0ec3-4139-836c-c37f5404f375","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10032648","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:33caeb12-3190-4dd7-a5d2-6006e5de5420","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1449","original_object":"UniProtKB:O43193"}
{"id":"c78dc561-9557-4d64-810d-b8cfef13782f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122705990","predicate":"biolink:affects","object":"NCBIGene:6872","sources":[{"id":"urn:uuid:785562dc-b6db-4340-98cf-05ff556deefe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9524","original_object":"UniProtKB:P21675"}
{"id":"b1d114c0-2e39-4271-884b-c34f3965d4ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2864836","predicate":"biolink:affects","object":"NCBIGene:1606","sources":[{"id":"urn:uuid:141fb681-6f51-41d5-9299-5c9917b51de4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13007","original_object":"UniProtKB:P23743"}
{"id":"08ecff43-29a4-4441-83c6-05035f0cddb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755219","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:9ff18891-b9e4-440d-b75d-ba3aeeac56d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6426","original_object":"UniProtKB:P41594"}
{"id":"f07d5422-db9f-4238-925d-29ecf63ffab4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:57582","sources":[{"id":"urn:uuid:2e5ec527-3fb2-4172-b13a-dbfdb1f8422d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:Q5JUK3"}
{"id":"c9f0caa8-48ab-4112-900a-89431beab2a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NCS2VAH93R","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:cb7b3d22-4fb3-4bcd-aa85-f18569a8441f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8436","original_object":"UniProtKB:P08908"}
{"id":"56570316-b99a-4c85-8e66-005a680326e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94302","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:d4418cf0-39a7-495d-863a-ed2b08b5574c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8011","original_object":"UniProtKB:P42338"}
{"id":"e628316a-ec70-4521-ac2e-645c3957dade","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93782","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:90866a9f-4aef-4e63-bd7c-032c077b3504","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9509","original_object":"UniProtKB:P08253"}
{"id":"78066343-d461-419d-b6fc-83f7d8a24d14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45483651","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:220cfe3a-7c1d-4234-9dc4-7de2a52d5721","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9193","original_object":"UniProtKB:P41145"}
{"id":"4510f2b5-d6ee-4f0b-9917-3c4c79d4db63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10461270","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:86bddb5f-f704-442a-a937-2f7bc58e3881","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2201","original_object":"UniProtKB:P30559"}
{"id":"9c7dda7f-bda3-4804-80e2-65936bad378a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53318014","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:6f07ce5c-e445-4888-a89f-403da9759aee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:118","original_object":"UniProtKB:P28222"}
{"id":"e2ba034e-719d-4de7-b999-e0d42a85b6cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:6ccb54c6-3ebd-4e2a-93fa-6a26836380c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:O75311"}
{"id":"30e9d716-140e-47f5-bd85-9f2de8dc978f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68647","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:0151d966-a538-4c31-ad06-273add2a6b8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5891","original_object":"UniProtKB:P15056"}
{"id":"c18ce9a8-236a-4ae8-bbcd-55f9283166af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23633470","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:19a27f69-cc90-4b70-a058-0bce35523c72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9451","original_object":"UniProtKB:P21730"}
{"id":"a35d7a5f-41b3-46e8-8dd9-3f9abea617b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311001","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:394ed554-e451-4ef3-8004-ce9370a1bc5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:341","original_object":"UniProtKB:P08173"}
{"id":"431e92a2-9957-4fd2-90e7-0abb3e8655c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92230","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:016e77c9-e36f-4801-b827-9b9fbcb639ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:954","original_object":"UniProtKB:P14416"}
{"id":"61c57296-18e6-4a4a-b930-798c5431d069","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85155","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:6fa57cf1-0458-46a3-a682-aad14080c55f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5742","original_object":"UniProtKB:P25103"}
{"id":"6d24c0db-4d56-4466-be88-080b66eaf386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91826678","predicate":"biolink:affects","object":"NCBIGene:29028","sources":[{"id":"urn:uuid:7f0d5809-4591-4513-b128-c833149ce9c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8732","original_object":"UniProtKB:Q6PL18"}
{"id":"aea7a1bf-0f00-4fdf-9dfc-a799e8301423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:0b984f80-4e2d-4e9f-a142-7831daf8fee8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P25100"}
{"id":"882e8ed2-fa95-4576-a1ad-33e6f0adbb77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4892","predicate":"biolink:affects","object":"NCBIGene:4883","sources":[{"id":"urn:uuid:098a6b34-16ba-45db-b840-04843348bace","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4892","original_object":"UniProtKB:P17342"}
{"id":"995d4671-07ac-4a24-afde-5aca4e49c8f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:d82368cc-07d2-4950-9b42-3dca8e8fe3be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P49336"}
{"id":"def83132-df31-4bc3-987e-b80f5d93c3e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118676295","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:0753986a-2002-4ab2-a6a6-b0ec87f275fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13885","original_object":"UniProtKB:P19099"}
{"id":"8dce6bc3-1477-4ebd-9df9-de47405f61a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:d0837966-8190-47cb-bad1-9c595aff77a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P28335"}
{"id":"e1aad9a7-c888-4380-8da1-2ceb9d83c79b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:3eea2d19-37f1-4c74-8c1b-0b95001ee49e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P07550"}
{"id":"a14aa98c-e536-4773-bde3-f2c309f5c865","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:06H865SCMW","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:1bbdae99-9a0a-47d3-a538-714a3fea06cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10162","original_object":"UniProtKB:O00329"}
{"id":"ed926700-7277-4a34-ac82-698bebe517dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3XVL385Q0M","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:0a1bf8b1-462a-4824-ae0d-be3fc3b37d29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7913","original_object":"UniProtKB:P29597"}
{"id":"1cff2a72-ae84-49eb-8357-088771150973","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:194328","predicate":"biolink:affects","object":"NCBIGene:1361","sources":[{"id":"urn:uuid:62bbe4b1-ffc6-44c6-ad4c-7e86df0bb0fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8656","original_object":"UniProtKB:Q96IY4"}
{"id":"1e315151-73af-4752-92f0-760aaebde7e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1732375","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:b866706c-108e-4bd5-8202-c3c3ed36cc44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7720","original_object":"UniProtKB:Q9P0X4"}
{"id":"e3ee0d71-950f-41ba-964a-8b5dc80a6063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311504","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:73df9926-e8da-4be2-a70a-ec4c0f2c7969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3448","original_object":"UniProtKB:P04150"}
{"id":"ab1581b1-cb6d-4956-ad7e-f5c41fd532fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699441","predicate":"biolink:affects","object":"NCBIGene:81788","sources":[{"id":"urn:uuid:c1a2aaf4-364d-4c19-bdad-56c11a98575b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11085","original_object":"UniProtKB:Q9H093"}
{"id":"7dde68af-9225-4450-bbb4-2c59db983983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10344307","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:3efec7d0-7703-40ea-b53f-4f0a87b9dd4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8629","original_object":"UniProtKB:P14780"}
{"id":"ff167553-8034-4842-838f-9b4113ad64a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6324620","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:7e3f7797-f37a-4674-a17d-d67962980d1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3882","original_object":"UniProtKB:P21452"}
{"id":"ea1370c5-9980-45a1-ae7d-6624c4ec312a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:9b505f9f-a054-4938-87d7-05f184c26f9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P28335"}
{"id":"68bcb5ee-1f88-4db4-a528-e46519681fa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:574","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:17d85e41-fcb3-428b-9028-a4ea4340b54d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:574","original_object":"UniProtKB:P21730"}
{"id":"243233ee-d3b5-44b0-b952-ed31f2f7c471","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871653","predicate":"biolink:affects","object":"NCBIGene:85443","sources":[{"id":"urn:uuid:68bdc907-a11a-49e4-9359-cca8c5f36197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8208","original_object":"UniProtKB:Q9C098"}
{"id":"8ee1ae42-8a92-4a8b-ab78-3f981a9c5d24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2154","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:a20eaea8-f91d-4eba-b158-d0b62f5a718e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2154","original_object":"UniProtKB:P49684"}
{"id":"e7e5a9de-ef3e-4f7f-b916-d0e14ff95450","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53490","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:97dd6575-2293-4a19-a4a4-6ffa4c91ff41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1022","original_object":"UniProtKB:P33766"}
{"id":"c6d1b97c-de4f-4e30-bcea-86cc5f5bccad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3897","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:b2ad42fa-d9c9-457b-b667-f08a38d59c1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3897","original_object":"UniProtKB:O60755"}
{"id":"4d318bea-7ddc-4183-b336-582f960b3d98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135316","predicate":"biolink:affects","object":"NCBIGene:1592","sources":[{"id":"urn:uuid:5782c4c3-01ab-4153-a604-13c3a6fadd1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5210","original_object":"UniProtKB:O43174"}
{"id":"04dcb1e3-7921-4c8b-b9c8-2dd21d712eaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1517","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:fefa6048-adfc-4c8f-8b91-629b691286b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1517","original_object":"UniProtKB:P49146"}
{"id":"678227e8-268c-4609-a499-65c551b86762","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46868971","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:d07f7abf-13f8-457c-a0e7-6647a917ae32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8159","original_object":"UniProtKB:O14965"}
{"id":"e631f6aa-7b71-4e73-bc51-294fabb02ba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7686S50JAH","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:8aaf34f5-1965-4063-b412-06b008e71096","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7443","original_object":"UniProtKB:Q05655"}
{"id":"855821b9-33d8-43f1-9765-0a7d417042d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030527","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:6e020918-e60b-437d-8477-15b2444f2902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10448","original_object":"UniProtKB:P35354"}
{"id":"0ebf5f0b-2dfe-4f00-85a4-07708f807c78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0XT2CPR891","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:e62563c6-f3e8-4dfa-ab62-c02c81c15250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12951","original_object":"UniProtKB:P00533"}
{"id":"a01d59ae-9448-49de-a016-428a34228308","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600923","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:eaf24f71-bdfb-4002-a05c-d625b4f22cbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10539","original_object":"UniProtKB:Q9Y2T6"}
{"id":"387a28d0-f937-4d5a-b5c5-2ac6dbd07272","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5289418","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:6730f351-6a7c-4219-9922-d7ef6e360853","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11743","original_object":"UniProtKB:P11362"}
{"id":"4e391bfa-05b4-4dbf-810b-907888b63508","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321168","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:ef8faf83-bbca-4c79-89fb-17e9c318dd4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10196","original_object":"UniProtKB:Q14831"}
{"id":"3b2e19ae-3d32-4aac-8ff5-643297ff3af4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3AK2RKG763","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:69514c15-b942-4af1-b7bc-8a375e2c705c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:497","original_object":"UniProtKB:P25100"}
{"id":"ca45e23e-b9f4-411a-aa9d-e1b2f99dbaa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:581F7DFA9B","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:50fdb84f-91c9-4203-bf82-c560161838f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10058","original_object":"UniProtKB:P20272"}
{"id":"991c5a3d-5d00-4a86-b985-bbc531d79986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48281","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:2b0ecd61-a6ff-4b23-bd0b-4d80a0f047b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:127","original_object":"UniProtKB:P28334"}
{"id":"64606b92-2318-4562-b220-2de05b0cae75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27432","predicate":"biolink:affects","object":"NCBIGene:294075","sources":[{"id":"urn:uuid:b228c407-0dcf-4a98-b99b-70dc1b50e439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1049","original_object":"UniProtKB:Q2AC31"}
{"id":"c155a609-654f-4989-b304-2874bf4770f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:2d53c447-ae20-4100-b34b-67eb636b55a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:O15530"}
{"id":"9582744c-e14e-4d68-bd78-9438049a055c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:9caee3fc-ba3a-4517-8d02-9b52f1cbd749","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P30966"}
{"id":"7cbb913c-6c5a-43dc-8ca9-339d47d9efda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:5dd5ca38-3eca-4c61-bf3e-9bcce3d1479c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P08912"}
{"id":"426a7607-3333-403b-81ad-a4d3b7929d19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92234","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:62f634d6-dacd-4e1d-8a6b-498b7172a057","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:969","original_object":"UniProtKB:P35462"}
{"id":"f6fcb2e1-074f-4fac-831a-81854bd82bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53312127","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:5a172d0a-dfd4-4247-ac7e-f32af08e20e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10938","original_object":"UniProtKB:P21453"}
{"id":"4b98d1e7-b035-443a-8e3f-2226a40659a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70983932","predicate":"biolink:affects","object":"NCBIGene:8493","sources":[{"id":"urn:uuid:7c5f9205-dc1d-4a98-8166-ef5f8e36c628","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11103","original_object":"UniProtKB:O15297"}
{"id":"2095ec5e-dad1-497f-b5c4-d1ec129c5df3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92814","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:668e9cea-65e1-472b-91ef-0afde2b2fe56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3283","original_object":"UniProtKB:P29274"}
{"id":"08f06b59-9c34-4768-a0b5-2583f484346f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93463","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:88444457-303e-45e4-a519-8bb2229670d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2114","original_object":"UniProtKB:P25103"}
{"id":"efb232b4-cf47-43a7-8222-c3e346fd2203","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J45910S3X","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:b83d9e46-e77f-4796-b715-e6fa08998211","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10314","original_object":"UniProtKB:Q16288"}
{"id":"1c58b0f4-05d5-4bb1-8d1d-6a2414ee17c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17115","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:1536127d-cfd9-49ce-9efe-9e81fd9f5235","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4171","original_object":"UniProtKB:Q12879"}
{"id":"44b09b03-840e-4ce1-a934-6172a500acb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:b554005d-63f6-4570-a4d1-5bd357cebab4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P08913"}
{"id":"e2c9963d-075d-4f61-b3f6-70cc619f0f7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R3I80TLN7S","predicate":"biolink:affects","object":"NCBIGene:4193","sources":[{"id":"urn:uuid:ae37d375-07ac-4ee8-bb26-570644f5df96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12941","original_object":"UniProtKB:Q00987"}
{"id":"70d45d84-ca35-41de-965d-03baebbe884e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6911854","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:edbc2005-ef8e-4c13-a756-6903f944789f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12456","original_object":"UniProtKB:Q9NYV7"}
{"id":"73d03fd2-0559-4fc3-b72c-626e9ee5b219","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:4b8c56a0-a7f2-4ebf-95e2-b81a21a92f12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:Q13258"}
{"id":"fdc5c8c3-f9b2-42ed-b759-677df842f94a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699446","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:6dcd938d-d151-4931-bcac-aff73c38ccf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11130","original_object":"UniProtKB:Q96RI1"}
{"id":"9e6f997d-9fcc-42a3-ac65-fdc005319569","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:84116","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:2f5ab7cd-f7c8-4866-b9f6-51c0c00cffaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1228","original_object":"UniProtKB:P35367"}
{"id":"1370ecef-aff4-4856-8fd6-88a9b970ce69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135935","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4067b77d-71d5-4b22-a405-4c28d8976fdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7477","original_object":"UniProtKB:P35372"}
{"id":"4eeb44aa-4e06-4f89-939e-a4464a660bed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71415","predicate":"biolink:affects","object":"NCBIGene:347411","sources":[{"id":"urn:uuid:1fde0b2c-17c0-40f1-b207-0568f1adcc64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10917","original_object":"UniProtKB:P0DKB6"}
{"id":"5c09be86-1862-4af0-9c98-b5fa050cf88b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73286","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ef646bc7-3db8-4419-a2df-851d4863e5ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:422","original_object":"UniProtKB:P0DMS8"}
{"id":"cf5be19e-93b9-426d-8435-7ca6d9523899","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194934","predicate":"biolink:affects","object":"UniProtKB:E2JF22","sources":[{"id":"urn:uuid:4a4aea2e-9851-4b4d-93ea-913bda9ceabd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10111","original_object":"UniProtKB:E2JF22"}
{"id":"197d1ac4-f448-453c-afb6-9360dfefc7e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5801","predicate":"biolink:affects","object":"NCBIGene:54106","sources":[{"id":"urn:uuid:3ab87fee-e967-43ab-a21f-d99224299a0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7198","original_object":"UniProtKB:Q9NR96"}
{"id":"83b43f9b-b785-4657-a7f7-f6285bc3f8aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71582672","predicate":"biolink:affects","object":"NCBIGene:233549","sources":[{"id":"urn:uuid:d9bda6d3-d349-49ba-91ad-285fb6183780","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12738","original_object":"UniProtKB:Q80W94"}
{"id":"7b8ea994-d013-4b0f-a1c6-97755467f548","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9950564","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:dcd169ac-bf7b-4de1-b3ad-f402c63ab52e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1854","original_object":"UniProtKB:P25105"}
{"id":"8591038a-e235-4047-9b0b-be33254734a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168268198","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:ca64207c-c325-4807-802e-af9e4174dc70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12764","original_object":"UniProtKB:P01116"}
{"id":"748fecc9-9186-497f-81b8-16101014e51e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59395852","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:62f2542f-b91b-4f7e-83b7-d64bc902b0f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13559","original_object":"UniProtKB:Q8TDS4"}
{"id":"43f536ec-7d43-4fee-876f-1c7a492581f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:33ebbb82-0179-425d-bf7b-96d4d7a1844b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P30938"}
{"id":"c56ef9a7-0b42-4cb7-bbbc-da3cf9c97537","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4708","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:8593c8f1-55e0-453a-aea8-fd5584d3cc2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7170","original_object":"UniProtKB:P35368"}
{"id":"317f1abe-91d4-4cbb-9468-bb152ed047c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GG91UXK2M5","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:9c06a450-204d-4624-af39-6aaff8623a8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11997","original_object":"UniProtKB:P08581"}
{"id":"89482352-5f7d-44a4-a9c8-0162ec020430","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733029","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:71953ca4-a189-45d1-802b-ce88d309f1ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7633","original_object":"UniProtKB:P08173"}
{"id":"5eb2b4a1-4709-4be1-a1e0-b29d288f2d09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4325","predicate":"biolink:affects","object":"NCBIGene:259286","sources":[{"id":"urn:uuid:e3f8f95e-9e82-4395-b75f-a24615a87df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10934","original_object":"UniProtKB:P59535"}
{"id":"89bfa813-4623-4c0d-999b-d8eaa867c94e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46225540","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:32132af9-bdba-4e98-b783-7c3a01de0efc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8181","original_object":"UniProtKB:P31751"}
{"id":"7a71f3e1-31a3-4a5e-be2a-f5d1a01427b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44584947","predicate":"biolink:affects","object":"NCBIGene:5045","sources":[{"id":"urn:uuid:2efd913b-2aff-4eaa-bac2-c524b7c7df3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8668","original_object":"UniProtKB:P09958"}
{"id":"c8fa28b0-5220-4ad6-b6f8-3650277e1d44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50861","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:bc6cc16b-ba10-426e-866d-b3c4d76062f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5820","original_object":"UniProtKB:P43116"}
{"id":"87df2f42-ecb4-485e-b506-97924f4dc381","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81724","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:f81c404d-bf30-42fd-bc49-d06e3dffe9cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10307","original_object":"UniProtKB:Q9UHC3"}
{"id":"2acb1ae2-bfbe-4395-b5c4-66df489c91f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7JTT036WGX","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:7dcaefd7-48d3-4c85-b607-dd00063ba120","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11623","original_object":"UniProtKB:P08581"}
{"id":"a756d5f8-d0d9-4b50-a958-0179b5acc7d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71223","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:f8cee525-4217-4412-821c-96b7536fee65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6840","original_object":"UniProtKB:P00374"}
{"id":"cec52ad5-0a1d-48da-94c7-1f70a4e96080","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9586","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:8be2ba12-1ae8-4c08-ab2e-9a16cdffddb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4685","original_object":"UniProtKB:P30531"}
{"id":"a82dcd3e-9d12-41eb-8186-7ce721cd3c40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132041","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:55dae5cb-97ca-4134-9e8c-a71550c6bf58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6373","original_object":"UniProtKB:P12821"}
{"id":"863d7a8e-6cab-4fb4-a576-8fcf3f9cdcbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:eace187e-afb9-475f-9de4-a6fa7eb032f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:Q13258"}
{"id":"3c88d4e3-27f4-418c-99e9-793d72ef0756","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2810999","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:950ad396-763e-4238-9535-31b003fc9a36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9543","original_object":"UniProtKB:Q99571"}
{"id":"f39b3558-6d0e-4c3f-843e-50a237146da9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91706","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:4140a357-b77f-4d89-a092-25d915fdfe79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2412","original_object":"UniProtKB:P97794"}
{"id":"1e1d8dc4-dbc1-4730-af71-b26a860a788f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2186","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:bdf6d17f-a706-48c2-b288-f334dfdc0cdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2186","original_object":"UniProtKB:P30560"}
{"id":"8b5f9fa1-ba14-4521-a266-f5670d39dbed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125525","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:6add9d7f-779f-4624-9da3-50e6b04e7fb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1238","original_object":"UniProtKB:Q9QYN8"}
{"id":"b475d782-bff6-408f-9b1e-587ab44ba1b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135261","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:bd819955-8a70-49d5-80f3-c5fbf2f5454a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:569","original_object":"UniProtKB:P08588"}
{"id":"f02698b5-9878-4be1-9798-fa11736932d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:aa06a379-49b7-4ca1-8b6d-2f48d14e74c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q8NER1"}
{"id":"b6da5283-8e74-440e-91d5-d5ce52f93012","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926513","predicate":"biolink:affects","object":"NCBIGene:57396","sources":[{"id":"urn:uuid:43ef74ac-34a9-4f44-98cc-37d3ceb8d3a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8161","original_object":"UniProtKB:Q9HAZ1"}
{"id":"2b9609df-8a76-4704-87c3-6ac83283c7be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151890382","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:ac145af9-99a8-42ed-872c-1ea71ac26695","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12244","original_object":"UniProtKB:Q13546"}
{"id":"d1ed6237-2447-4d16-8144-59c71a91c98d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:45d18362-cec7-4830-88df-2b28064d71f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P35372"}
{"id":"1a3dfc78-abfd-4f29-bc0e-0897caa267b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:bc6bd5ee-baff-40df-a6f8-9afe82556835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:Q13639"}
{"id":"ac72f629-9345-44c5-802f-aeafd98c425b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:50488","sources":[{"id":"urn:uuid:2af2aaa8-80d4-4486-822e-f7f308ad3557","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:Q8N4C8"}
{"id":"946aeeab-d367-464c-b567-45559f0d37aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3964633","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:4e79d783-85e0-48ff-ae6d-b636abd04484","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1398","original_object":"UniProtKB:Q14831"}
{"id":"c60406bf-3ccc-4a65-b8ca-97624cfeb21b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10236","predicate":"biolink:affects","object":"NCBIGene:3678","sources":[{"id":"urn:uuid:75a8ba58-13f4-4f46-9f4d-0862955a7b37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10236","original_object":"UniProtKB:P08648"}
{"id":"9e4dfdd4-9b4a-42c5-a1b8-48d104332da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3081333","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:82dabff9-27e2-4f2a-9267-9f1b35e32b39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1010","original_object":"UniProtKB:P21451"}
{"id":"29b2c8cf-c809-4740-803e-bb0409e64dd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3001","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:465fce36-b81b-44fb-b5a6-d7ca537ea15e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7059","original_object":"UniProtKB:P04150"}
{"id":"6061a9c2-dfee-4163-b2d9-60631611d466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1912564","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:45128db7-dc57-443c-acda-ffb6970e1c6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11211","original_object":"UniProtKB:Q9NQS5"}
{"id":"e75dfc20-2942-4d87-80c6-c2a89a2ad9ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92844","predicate":"biolink:affects","object":"NCBIGene:641","sources":[{"id":"urn:uuid:4aa43635-b55d-4274-8b42-27fec16a7180","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13026","original_object":"UniProtKB:P54132"}
{"id":"5b6eda14-a708-4f6b-a683-7b6c85378d84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:658","sources":[{"id":"urn:uuid:6a318d66-197a-4f50-a31c-4f76d542f7b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:O00238"}
{"id":"325fc075-940a-461e-b076-dfcfa0929299","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G8F040299R","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:6a99c95a-6c04-4ce6-a9b1-5357529d0190","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:974","original_object":"UniProtKB:P30729"}
{"id":"86eca452-0e4a-4f44-9daa-f8e6982558de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71957","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:73def6fc-bff3-44ba-8d2c-48572311f93b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7963","original_object":"UniProtKB:O00329"}
{"id":"5a5f98e5-ebe4-4007-8a9b-c17bed1c9a4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817484","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:bb63355c-51d7-41eb-a748-b29df999198d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6117","original_object":"UniProtKB:O08726"}
{"id":"789fd41a-d769-4379-8dba-ce7064dc3b61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48861","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:e355fcec-d6ee-4f5d-b2ae-3475ffef5967","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3052","original_object":"UniProtKB:Q03426"}
{"id":"546f7b0d-6c32-4f9f-ba0a-f39fd5f9af30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189802","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:76cfd3fd-66f8-447b-972c-bf2305a1d53f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12994","original_object":"UniProtKB:O00519"}
{"id":"68e5248a-8277-407a-a880-f3ab852bbba5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138865","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:f47a23c1-1d8f-4824-8721-be01d677e23c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8580","original_object":"UniProtKB:P61073"}
{"id":"7938fdce-2853-4284-874b-fdd92c334824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156565109","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:af2466a4-2b3f-43fe-b8dc-a4758e318179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13735","original_object":"UniProtKB:Q06187"}
{"id":"fee99ef5-9a13-4fab-a6e2-d173004312c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155541857","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:0d79b226-08d7-4431-8610-e4712d8d837a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12547","original_object":"UniProtKB:Q9Y5S1"}
{"id":"8b1d33a3-8cb5-49cf-a51e-6c493f9d43a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117902000","predicate":"biolink:affects","object":"NCBIGene:5587","sources":[{"id":"urn:uuid:1cb5548d-017c-4920-bd6b-33f861e80b3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9964","original_object":"UniProtKB:Q15139"}
{"id":"1d479c96-9acc-43e3-a1bb-e3bd7a235013","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149970","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:91a5ef91-f95a-4583-9d11-a3e47874d7b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11173","original_object":"UniProtKB:P0C6U8"}
{"id":"43683573-2568-463c-8e16-8951d04c9425","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X4D0G881CN","predicate":"biolink:affects","object":"NCBIGene:81600","sources":[{"id":"urn:uuid:88233b8d-7dec-49c9-a047-8e01c208b136","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11617","original_object":"UniProtKB:Q91XA9"}
{"id":"0db97bf0-b196-4371-9b3a-334e0a40a74c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76IND1BS43","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:b4a90245-278e-4847-9dbe-405a0209aea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4154","original_object":"UniProtKB:Q13224"}
{"id":"ddd1c628-1026-4b8a-87ae-3ef8bf9e118b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38895","predicate":"biolink:affects","object":"NCBIGene:25456","sources":[{"id":"urn:uuid:e7b03122-619f-4e53-87e7-3e00fdf73d70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2368","original_object":"UniProtKB:P20781"}
{"id":"c49d1b2c-0fe3-4d06-a450-08b57fa73a3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44134520","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:7c9fa15a-0a73-4574-a4c9-7ea635e01455","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2257","original_object":"UniProtKB:P41586"}
{"id":"7834f6e2-2725-4a00-90e4-3db644834363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132914","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:7f959843-dd46-4b33-8db2-a76f33b53fbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1162","original_object":"UniProtKB:P30968"}
{"id":"beeba4c8-e3eb-4f6e-abcb-e10b563763b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136051","predicate":"biolink:affects","object":"NCBIGene:4352","sources":[{"id":"urn:uuid:9ac2fbd1-312d-4a27-bbcc-8295aa2ce625","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10032","original_object":"UniProtKB:P40238"}
{"id":"b76b6ddc-b913-4aec-8084-66fe61796cea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9838905","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:ed736e7d-f323-41bd-9d1b-f2f48e58c133","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1243","original_object":"UniProtKB:Q9QYN8"}
{"id":"8789b2c5-fe4f-4e70-aa8c-4cacd64bbc8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137300622","predicate":"biolink:affects","object":"NCBIGene:115004","sources":[{"id":"urn:uuid:be2b7950-8ad1-4dc1-90c5-a13f0e5bb83d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11324","original_object":"UniProtKB:Q8N884"}
{"id":"bfa4a3da-d4d4-4f0c-8b4a-44d84d25d2b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177570","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:1ac315e0-2ffe-47ee-879b-7f42b67ea415","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9343","original_object":"UniProtKB:P30968"}
{"id":"f8e166b1-bb0c-43cd-9957-418f739c13a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6249","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:8787589e-e2c4-4dc4-bbcd-3c976060c68d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6249","original_object":"UniProtKB:P25090"}
{"id":"98bfc0b4-abeb-46dd-9011-c0782880eace","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2060","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:e8101ac0-8773-49e2-9688-c83b608449d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2060","original_object":"UniProtKB:P30938"}
{"id":"96ff6a6f-13b1-4f8a-9f62-de8f878bb876","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8375F9S90C","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:5818f8a7-cb77-4a3d-8b4f-d81386dfbe38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12345","original_object":"UniProtKB:Q9UGN5"}
{"id":"60e67d40-f680-4e6e-9c98-2584cf89db67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:bc3348e7-970c-48a7-b8c4-e95cec2c1862","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P61169"}
{"id":"5022a1e6-a0a5-45d5-8bd4-71f26f8de93b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PUX4NYC22L","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:86380436-7b51-4d17-9fff-6ab5b73191da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1360","original_object":"UniProtKB:P48039"}
{"id":"f1036433-0356-49db-aa90-ef2ee0e96f10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91628","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:a1e1177c-6039-41c1-9cb9-af6ab3df1c96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:541","original_object":"UniProtKB:P08588"}
{"id":"837ec619-b4d8-49d3-b1b0-c52a3e2580a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7939","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:bcb2c13c-72d8-442d-a986-f14cf8de05ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12428","original_object":"UniProtKB:Q9NYV8"}
{"id":"4c5dd56c-a295-4279-9d90-0d3315ccfa25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:a3ced23a-9a16-4bbf-ad2a-9a7cd3c30073","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P11229"}
{"id":"3c1ce93a-3fe2-43b9-be1f-c4997a7894e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:25187","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:a5551872-059e-433c-b0da-df2a7b4c6958","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2430","original_object":"UniProtKB:Q8BLA8"}
{"id":"d52e83e5-7433-4ca8-a2dc-605ade2fb4dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25053598","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:761a518c-a843-4e47-8911-b8733ebe1cf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10066","original_object":"UniProtKB:P17252"}
{"id":"894806e3-7230-49e6-8627-8b811cc8bae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233324","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:28958196-c848-4c2d-92b6-693b451f179e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11186","original_object":"UniProtKB:Q04759"}
{"id":"9983cd47-4f63-4ee8-acd9-7a56394169ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:9a7959e3-56fa-4652-a0fe-5989ce42299f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P35968"}
{"id":"39c36811-3452-441a-a1e1-00b408686011","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755145","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:4aa26895-b10e-4e1d-870a-55846623ee1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5712","original_object":"UniProtKB:P17948"}
{"id":"6b33a98c-7a50-424a-8078-e6d67097cc66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8205","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:b2960d4f-791b-4d28-bc3a-738a4b5ab391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4286","original_object":"UniProtKB:P23415"}
{"id":"79da28f2-c621-43e3-b997-76c2939129a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31684","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:3f191854-670f-4754-944d-d786830335bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7399","original_object":"UniProtKB:P27815"}
{"id":"0330d7bc-9ad9-4790-8909-ad5bae9de061","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93039","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:e492a3f5-2fde-4f78-a289-bf36b628b452","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:741","original_object":"UniProtKB:P20272"}
{"id":"9f049e18-7149-4f67-a9d7-66c7bdc4e1ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:6743d6ff-811c-4f05-8089-12e6d9ce1bea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:P06239"}
{"id":"5fa74882-dddb-46d4-85be-88a0cfb5e05c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92321","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:b8e05484-f8dd-4340-bf06-5dbd9497d079","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3927","original_object":"UniProtKB:P28566"}
{"id":"d88d8636-9f5b-4a70-a527-2d49b22435ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:532OV6WA05","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:0ea21cb3-298f-4025-9f8a-045fba81a768","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4119","original_object":"UniProtKB:Q99572"}
{"id":"f30c3881-cd16-42d0-af34-86ed92497bdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7822","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:67541d2e-054a-467b-86c2-2b8ca2116980","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7252","original_object":"UniProtKB:P35354"}
{"id":"24f20348-32fa-400f-8382-35f8b49137ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:142411827","predicate":"biolink:affects","object":"NCBIGene:4217","sources":[{"id":"urn:uuid:cd3af9a3-7910-48f2-aab3-44bb0c596f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10602","original_object":"UniProtKB:Q99683"}
{"id":"bd4006d6-1ccc-4ab9-a054-b11b8edb7b89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92848","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:c3bfde6c-7996-4126-9a2c-014870ea3385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3286","original_object":"UniProtKB:P30543"}
{"id":"1a6d560c-056f-4627-a109-f9d9430ed3d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56929387","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:eb586db2-3c8f-42b0-b68c-7e917243816c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6369","original_object":"UniProtKB:Q8R455"}
{"id":"59bee621-ed10-4eb7-a0c8-914c7969d93e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I5YE3I47D8","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:c039fdb5-4d35-4f6a-b96e-d05feeaa4eb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6418","original_object":"UniProtKB:Q9NQA5"}
{"id":"80ec47fd-0999-4339-9573-8c79a142f333","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229220","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:3b669cf8-ee7c-4c99-9557-c810c204e3bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10316","original_object":"UniProtKB:Q9UM73"}
{"id":"75c51e79-092c-42c7-ab60-3ffed35530c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311175","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:9aa2fc41-1a91-45f0-8718-7b1f5a4c03f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1938","original_object":"UniProtKB:P30557"}
{"id":"cffdac77-2abb-4916-8e38-18c1e14e23ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:bff1d0f7-5667-4e6b-b8ef-a18bfca2ad3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P08909"}
{"id":"8fb06f36-dab2-438e-a0d7-c42028a01f53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164234","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:927e109f-f1ba-4760-a042-5b61da4677d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:643","original_object":"UniProtKB:P46663"}
{"id":"a03f6eff-0757-4943-b8d2-640a71d8649d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146225852","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:aef07e50-e015-496a-b7b6-940f305a07d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13504","original_object":"UniProtKB:Q13546"}
{"id":"9c154992-2b84-49f3-84e7-007ea24dd8a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1683","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:475a2deb-6614-49ab-816c-a622764ffa45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1683","original_object":"UniProtKB:P41146"}
{"id":"e577e98b-e542-4db4-b703-62848474c5ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:d7885575-a660-443b-81e4-57617d0b0ac5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:Q13547"}
{"id":"f526a85f-afb7-497b-a188-c698bdb6e393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4702","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:b7cc8294-4435-41ad-90c1-97707338cea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6810","original_object":"UniProtKB:Q9ULX7"}
{"id":"5ff63519-5d4d-404b-81dd-b7b16241419b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:156153","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:5435b9ae-b47f-4848-9c08-3c04af2c8814","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2786","original_object":"UniProtKB:P11473"}
{"id":"4d879fd9-803b-4165-be29-1cd30276b9db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46830123","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:d02478c4-ed99-47b6-bdb8-585ac5509176","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6321","original_object":"UniProtKB:Q14416"}
{"id":"509c2bd0-b3ba-49c2-8337-b73ef7b4b5b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13579","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:6765f073-7a77-4ffd-8c44-d428ef951251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13579","original_object":"UniProtKB:Q12866"}
{"id":"f23dcdda-b2e5-49f8-8be6-380ee0639f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:3cd52472-1c52-48bb-980c-c111356d08c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:Q62758"}
{"id":"18ad9462-79d9-48f7-9ac1-fa5e6a796851","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2549","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:aee2a0e2-61e6-4026-95d1-4cdbe1890811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:558","original_object":"UniProtKB:P07550"}
{"id":"91f0e4c2-1e9c-4bb6-92a0-4badefe94e67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996515","predicate":"biolink:affects","object":"NCBIGene:8111","sources":[{"id":"urn:uuid:747f16bc-898d-4b23-b619-81fc36c381c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10572","original_object":"UniProtKB:Q15743"}
{"id":"1e68e841-da34-4db2-9514-7fe8adfc5ccc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277840","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:c7fa12fe-1adc-4033-b40b-cc5b1953ce0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7799","original_object":"UniProtKB:Q6DWJ6"}
{"id":"87c30233-331e-4304-8758-4ff88cf2187d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:6c5ba097-4ffc-43b8-bfa9-8a84f22dcd91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P61169"}
{"id":"983dd1cc-384b-456b-a0ea-1685d2e3d55b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72441","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:8a700dbb-3dc6-48cc-b3a6-f3d59fbea282","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8372","original_object":"UniProtKB:Q9UBN4"}
{"id":"68c38367-f0ce-466a-9ee7-916bab063b5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1335","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:23dac05d-add8-4572-b164-9aef7b218086","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1335","original_object":"UniProtKB:P41968"}
{"id":"9499960e-ae63-4dad-80da-4fe5b73193a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2562","sources":[{"id":"urn:uuid:ad3425c3-6d5c-414d-b9f2-4c16547795f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P28472"}
{"id":"5ff3f96a-7b99-48dc-ac27-80a32418e237","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9943","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:59e9a5c8-0919-4f57-9002-900a71946ab7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7321","original_object":"UniProtKB:P31645"}
{"id":"64058d77-7857-4dc1-b9b6-ae40c196f8d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2423","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:222b1ea4-4adc-4cff-b233-2c335c43e97c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13381","original_object":"UniProtKB:P07711"}
{"id":"194b50e8-d9dc-4b04-85d9-c807a4e49de4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:43327825-6236-4202-837b-7c8e86877a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:Q15858"}
{"id":"7566296e-ba70-42b9-9329-a21158725f67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:11540","sources":[{"id":"urn:uuid:fa815146-c5a8-43ec-9b1a-988f4c438408","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:Q60613"}
{"id":"38d913dc-df91-4320-b6eb-7ed23a2ff2b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:4735256a-5543-49e9-b9fd-a7b5055e43d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:P30680"}
{"id":"e368c5f4-428c-4bbf-a86b-baf9f874ecda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311079","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:26a0a19c-7e96-4183-b6c9-38b2a529d2ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1400","original_object":"UniProtKB:P31422"}
{"id":"af3c6581-2ce4-4301-94f8-c8aacd22e783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2158","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:863bccf6-02f9-4a04-be3f-e853f973db88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2158","original_object":"UniProtKB:P49684"}
{"id":"529e0877-b676-4aac-88cc-396c0b73168b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133823","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:25460385-03f0-46b5-95e1-7aa8ad6ff231","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3592","original_object":"UniProtKB:O88626"}
{"id":"afa1a415-de95-4bbc-adae-2bfe6ba1d8ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZET7B198W2","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:8f78bf27-7ccb-4236-b8f5-825697858db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:525","original_object":"UniProtKB:P08913"}
{"id":"504800a4-9999-47c8-ba53-b2b62d9f0f49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5G4XF6VU2Y","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:07ea600e-bf4a-43c4-87d5-2b6929ba1455","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11711","original_object":"UniProtKB:P51449"}
{"id":"518ffe8a-660d-46a7-9dcd-23f4186e7fc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11847343","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:89dfaf66-818b-4c9d-bca2-9947ff4daabc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8768","original_object":"UniProtKB:Q9UQB9"}
{"id":"0d925c68-8407-4785-aef1-15d23bda9057","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:b530c7a3-e491-4dc6-95fd-4f7c0034aa48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:O43603"}
{"id":"e9c7c26d-e832-4023-b371-7316e959d05b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:6de16bd7-c098-44db-943b-eac68a5db6c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:P07949"}
{"id":"9154e30e-542d-4ed2-912a-26f3c903ef41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118663155","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:cfedaeb0-392f-4834-a600-7d3a2fe768d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9228","original_object":"UniProtKB:P11229"}
{"id":"f4ddabac-ac48-4759-88bb-5de384a983db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134163708","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:d2da27bb-f7da-4aa9-9d6f-58458b2fd8a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10233","original_object":"UniProtKB:P42338"}
{"id":"08cff6f6-543b-49c6-8bdb-35170ac71992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:76d7c22f-ee3a-4106-abd6-dc9576b8e79b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2486","original_object":"UniProtKB:Q8NER1"}
{"id":"7bd18cbc-8271-4e59-9078-7bdfa032e801","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2702","sources":[{"id":"urn:uuid:b494a75b-25c7-459a-bcff-f7551ffefecf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P36382"}
{"id":"1d5944aa-aca8-4d21-9dc4-9f431eb6f26d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3DRR0X4728","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:440a0920-a058-471c-8144-6250150ecae6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12286","original_object":"UniProtKB:P25101"}
{"id":"6613e931-406c-406b-ae47-68f7f8855341","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1990","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:f494c77b-7d9d-4d1f-9eb1-64ca66292059","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1990","original_object":"UniProtKB:Q8TDU9"}
{"id":"6f78f628-5640-41df-96d3-b96451876653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132141153","predicate":"biolink:affects","object":"NCBIGene:27163","sources":[{"id":"urn:uuid:067b3696-c33c-4973-8c43-e9f363a6c953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10121","original_object":"UniProtKB:Q02083"}
{"id":"d1b66846-83b1-431b-ba11-73d8944d6d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:e75dffaf-58de-420e-a91b-3a3263f4b159","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:O35811"}
{"id":"8b2a473a-bffd-4f87-a80f-f9f22f57680e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:e3a8ebcf-d5a3-4395-91c2-c11bfa7500e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P30939"}
{"id":"eda13944-17d7-4334-bcec-3051f630360c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1687","predicate":"biolink:affects","object":"NCBIGene:18389","sources":[{"id":"urn:uuid:a39e1a57-3d5b-431b-9183-9c8c3eddc9ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1687","original_object":"UniProtKB:P35377"}
{"id":"2c2da4fb-4ccf-4235-93d4-0f7dc7ef8bd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TD3SSC2VDF","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ba1a344f-62d9-4962-aaaa-c60530e0b98e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11959","original_object":"UniProtKB:P28223"}
{"id":"35d31bf7-f508-42d8-8f87-33523e9d9ca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4172142","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:bc0c9f83-74fa-40d1-8d43-5e03a9a70551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1350","original_object":"UniProtKB:P48039"}
{"id":"5a16ff37-fe18-40e2-a314-1c803804fa40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:29262a97-c60e-44fc-abf0-de999b86007f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P47898"}
{"id":"fede990f-da20-4863-829f-984219630935","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3964","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:ccfa189f-e46a-4ef4-b7e9-0233902132f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3964","original_object":"UniProtKB:P36544"}
{"id":"d0ff333d-a999-47e2-b6f4-7f52de98166f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433305","predicate":"biolink:affects","object":"NCBIGene:7052","sources":[{"id":"urn:uuid:01292a72-7843-4885-a361-7e92715d42ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12803","original_object":"UniProtKB:P21980"}
{"id":"564687c9-e15d-41af-b597-3cee78233f8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8979","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:677a6e79-6cd3-4606-baf1-0f7f2f428f6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:192","original_object":"UniProtKB:P41595"}
{"id":"5d069659-c3f6-42a9-909d-82d66dff522a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3754","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:10d84385-9e86-4d99-94cc-17acb418542a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3754","original_object":"UniProtKB:Q8WXD0"}
{"id":"87e8fbf0-0e66-4783-8eba-de7c0d7418b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7W3V82OQ0P","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:0982d4f2-a769-412c-84ae-73ae7ae6281b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8250","original_object":"UniProtKB:P10721"}
{"id":"823ef915-9087-4d08-9021-ae131d2c740e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:f2782f50-74ce-4a91-bcaf-693d2fe37245","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:P22001"}
{"id":"d3c35942-8546-44e7-86c6-6ba17d788735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53378752","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:8ee43fb8-479a-4b72-84bf-810beab51307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10283","original_object":"UniProtKB:Q9Y210"}
{"id":"85b9da85-e46a-4195-868b-26b5a6fbe7fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156011010","predicate":"biolink:affects","object":"NCBIGene:641","sources":[{"id":"urn:uuid:c9e1fc39-c26f-453f-9217-23adc7b752aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13040","original_object":"UniProtKB:P54132"}
{"id":"7d721f3c-f315-4896-b1c0-81c4cebd9252","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146971285","predicate":"biolink:affects","object":"NCBIGene:4836","sources":[{"id":"urn:uuid:8a7b343b-2d60-405b-8216-d3c26d5e1255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13849","original_object":"UniProtKB:P30419"}
{"id":"4b3211dc-f7f3-4b4b-a0eb-3dcf41947e46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92591","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:08d361a8-e02e-4e9c-96af-c8bfad6ff7f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3221","original_object":"UniProtKB:P28222"}
{"id":"bd2a2ace-65a5-4f55-a774-5567d56d9059","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918583","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:4cfaa96b-1681-49e9-85d0-b651521b574b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4257","original_object":"UniProtKB:P47869"}
{"id":"f2caae0b-d3f1-4369-bbbf-501c9ebebce6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135694","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:006d29a3-1bae-4a95-8901-8c7bba6e6b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2197","original_object":"UniProtKB:P30518"}
{"id":"bf0b9a05-aed1-4726-bb70-5c060e423d22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5763","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:46a1d228-7ae3-4bf5-ae6f-6419102ea06f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5763","original_object":"UniProtKB:P21730"}
{"id":"62c8b8aa-5545-4612-80c2-3fc7e28ea173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73337","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:6462feab-1a23-4fa4-90cd-4ac59306c8a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1236","original_object":"UniProtKB:Q9H3N8"}
{"id":"aea49256-452a-48bf-909c-e64b70ab7369","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:258351","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:48c8b187-349b-4d0f-ad85-c46e77da5a98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:555","original_object":"UniProtKB:P08588"}
{"id":"bfd1c5ad-c700-4a8c-a6f8-cb822c123f02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135952","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:cd569d70-48f4-4b14-8bff-0d8567df3763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11576","original_object":"UniProtKB:Q8NER1"}
{"id":"dbdf7170-5374-47c6-9890-b8739652e35f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16243","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:401170e2-852c-4e4e-96f5-176f2b9faae7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5346","original_object":"UniProtKB:Q16678"}
{"id":"548d1a84-fdaa-4d21-92e9-2232931531d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:a325f6c6-6a61-498f-b8aa-572cea36349b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P08482"}
{"id":"7a4a7645-1582-48ed-b38a-3d29c30a3fa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z0O8PGE4TB","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:d9a8c078-86f2-4cac-a636-93649b5bbe56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9050","original_object":"UniProtKB:P97612"}
{"id":"e6dcc19a-df6e-41eb-9290-6bbb5b260480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H62AOA2IYF","predicate":"biolink:affects","object":"NCBIGene:6096","sources":[{"id":"urn:uuid:6a21d092-9244-4418-aa57-846d5a075516","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2740","original_object":"UniProtKB:Q92753"}
{"id":"f66dbda8-c7cb-420a-add4-5ec439ce128c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277837","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:c4497a7e-64be-4d8e-9435-f40ae919dffc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7771","original_object":"UniProtKB:P49286"}
{"id":"fea96e24-95de-477e-acd4-60662fe31f1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3175","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:badcdf19-cf95-477d-a9ad-b4754bb8feb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:520","original_object":"UniProtKB:P18089"}
{"id":"085281df-211b-4e56-8f82-09e0bc3dc842","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:1de6048c-705b-4cb1-a61a-ff3956b48c01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P08908"}
{"id":"6303e7b5-3a77-4b10-9d8e-6b18c8a4c413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114187","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:36df07ff-567e-4b20-a6cf-ed3a59214209","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9002","original_object":"UniProtKB:P41145"}
{"id":"90020ce5-7a84-4872-9d80-67375f86e7a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:668U999F9T","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:3555421c-ae15-49ed-8ffb-684771223924","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10684","original_object":"UniProtKB:P30988"}
{"id":"48237383-afc1-4746-a406-18c20a47143d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:452f50d6-33b7-40e1-94b5-2f2e793c0b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P07948"}
{"id":"8084e2c0-9142-4551-99bc-57ebb5c5a7af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10197","predicate":"biolink:affects","object":"NCBIGene:8324","sources":[{"id":"urn:uuid:9f8edc18-1be3-4b09-b694-0e2635a67c64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10197","original_object":"UniProtKB:O75084"}
{"id":"d6b07a0e-83b7-4645-bfe7-cfd01f300240","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94411","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:b1438143-26c6-4149-a9a1-ad8df50958dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10470","original_object":"UniProtKB:P20309"}
{"id":"47921a00-025b-41ea-b583-81a709c25ccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8GYW8T88JI","predicate":"biolink:affects","object":"NCBIGene:6555","sources":[{"id":"urn:uuid:be2a3d2d-9bce-46e6-86d8-2c5f41d57997","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6529","original_object":"UniProtKB:Q12908"}
{"id":"d4a5c274-6574-4e12-ac09-f9ccf30313f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4326","sources":[{"id":"urn:uuid:71932157-6c1f-4c43-b608-a702ceeccda4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:Q9ULZ9"}
{"id":"9bc1703e-5c70-4783-8fe3-42b2aff749d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:65UT4V5Z34","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:40d1de87-1b86-450f-bb52-c99be0a3a545","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:348","original_object":"UniProtKB:P08173"}
{"id":"7bbb433a-2b76-44b0-bf5d-08ea1e9d86ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94513","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:c0ab5639-a41b-42d5-bff2-9372d85d3627","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6828","original_object":"UniProtKB:P43166"}
{"id":"8e7e2969-132c-4a42-bec7-0db566452e60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827372","predicate":"biolink:affects","object":"NCBIGene:65980","sources":[{"id":"urn:uuid:b9debad5-fa76-436b-ab84-101e037e4434","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8572","original_object":"UniProtKB:Q9H8M2"}
{"id":"c59a7c45-eada-4a26-b4e9-00b75e522218","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233052","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:83511972-df2a-4961-832c-2e52739f65e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7501","original_object":"UniProtKB:O15379"}
{"id":"71acb0c8-9d89-4177-801a-79e63dd18142","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11245287","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:9fe7b783-cff1-4372-9501-1f055b316a3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6363","original_object":"UniProtKB:P23385"}
{"id":"595e31f9-c25e-4377-8813-47ffd526a1a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3781","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:aa49832f-5cf1-4b37-810f-24d447f9bd2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3781","original_object":"UniProtKB:P32239"}
{"id":"1222c631-c210-4559-9b5f-359519e3c511","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47458","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:63eb5057-02f8-484b-9456-207e993a69f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7731","original_object":"UniProtKB:P07947"}
{"id":"9d1a53fa-ef7f-4be1-beca-f1a18c1a3f8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1158","predicate":"biolink:affects","object":"NCBIGene:2492","sources":[{"id":"urn:uuid:ce6875c3-9b45-4271-ae62-cee5c9e132ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1158","original_object":"UniProtKB:P23945"}
{"id":"7df71a0b-e4cb-4649-8f47-1e39d5e039b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:3539e52e-f2b8-480c-a68c-9e3337963ca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:P42336"}
{"id":"095fe6b9-22ab-4fa0-ace6-f2200257e461","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:14053593-3202-457a-ab06-8bd42423394a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P21728"}
{"id":"5a5cf352-d5b8-483f-8297-ced36a8f3a24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231684","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:efb60823-793b-4da7-bbde-f21300001495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8228","original_object":"UniProtKB:Q96P20"}
{"id":"80db0dda-34ec-47a4-a39c-ff76df84467f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5306","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:c03f792f-0740-40e5-8b3a-316ea43c2252","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5306","original_object":"UniProtKB:P30989"}
{"id":"d83627ea-6c78-46e4-8371-32858cba21f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:a8be03fb-640e-4a63-a938-80c645cfd64d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P41595"}
{"id":"bd860616-1e4a-4f2c-9f18-00950450d0cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68453302","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:68f485b8-d358-4cb9-bab6-be2df74fbf7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12197","original_object":"UniProtKB:Q92793"}
{"id":"aafd2a56-c106-4898-a355-d42753cc46b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VYI79FLZ6W","predicate":"biolink:affects","object":"NCBIGene:9975","sources":[{"id":"urn:uuid:8f92cbe8-9fa9-462d-97de-889edd97b9af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8900","original_object":"UniProtKB:Q14995"}
{"id":"d310ccd3-51df-483c-9e23-e0dfe375637d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:816","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:3cf81345-3507-4969-9224-d5c37f8cd71f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:816","original_object":"UniProtKB:P51685"}
{"id":"8b29a1bf-d15a-40a4-a278-b7cd6dd33658","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195581","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:b4ed3ab0-52b5-4bae-a7ba-1b7bfca02da6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12447","original_object":"UniProtKB:Q9NYV8"}
{"id":"1391d5ff-eac1-4739-93a9-99ce823baf59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163889","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:40107289-da4b-447b-994f-0a72cce87fc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:446","original_object":"UniProtKB:P29275"}
{"id":"1bd942e7-0f2b-47a7-9700-333767744cb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:039d2711-6e67-4359-bd8e-2104f9a9578c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q13507"}
{"id":"48e300e6-0dc0-40d0-b2dd-040c0aff4622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71682837","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:c96e0ef6-c4e4-439d-bc2d-f15b6d65b318","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12119","original_object":"UniProtKB:P48736"}
{"id":"20f2bc86-6be3-490c-b363-86a28c3e019f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13953710","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:7f51d2c4-5b4f-4979-ac4b-994247fc5d15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7514","original_object":"UniProtKB:Q15059"}
{"id":"443b4458-b5b9-4da7-b3f6-0ab484e63d60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:513P80B4YJ","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:94941a68-b390-4c62-9406-894a79446abd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10368","original_object":"UniProtKB:P10721"}
{"id":"18e8e198-e90f-43ae-a6c0-617a61a22cb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867828","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:9f3366dd-4fb1-400f-8a2f-e2c804c6bffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5821","original_object":"UniProtKB:P30557"}
{"id":"584315a7-a423-43f8-ba03-67aacf1a6f3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90469849","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:222285a6-9f93-40f8-b84b-e021749ac5b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6088","original_object":"UniProtKB:P47211"}
{"id":"c7d1d811-18f5-417c-affb-ae7862961e1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:73I34XW4HD","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:35517547-a12d-44be-b3c4-ddee99b4747d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7959","original_object":"UniProtKB:Q15759"}
{"id":"63c2cae3-c761-4b21-a737-9092bb14db82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5847","predicate":"biolink:affects","object":"NCBIGene:7298","sources":[{"id":"urn:uuid:b6d74f58-9796-49fb-91a9-76262762830b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7403","original_object":"UniProtKB:P04818"}
{"id":"6e752d85-e82e-46da-985e-a5a3ebe6a7ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755161","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:7b815be7-570e-46e5-834a-cf76caf1a609","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5834","original_object":"UniProtKB:P25090"}
{"id":"7438c36e-6988-4490-9cd1-59ecf094d119","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36511","predicate":"biolink:affects","object":"NCBIGene:1185","sources":[{"id":"urn:uuid:1165d38d-3a17-46ea-b974-caff36449db6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4177","original_object":"UniProtKB:P51797"}
{"id":"64bcd013-17e0-4e34-a57f-12b648c20507","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138424","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:13f71e17-aa7a-40df-9c9c-8d95887a8449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2508","original_object":"UniProtKB:P57789"}
{"id":"113dbd9a-6296-4ac8-9981-b1808b23697d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A49A7A5YN4","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:f3ac47c7-a115-497d-9097-2d04a8090bd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10477","original_object":"UniProtKB:P00533"}
{"id":"7ff97d85-9433-4258-a69f-cfcbe504fc94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139520309","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:4165a749-8f2f-4632-944e-e2c0b35f9800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10689","original_object":"UniProtKB:Q13627"}
{"id":"9f6e80f3-c91a-4792-813b-1e4c08905687","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310960","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:33896b51-cbea-4bfc-8fe5-5460b47ff909","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:459","original_object":"UniProtKB:P0DMS8"}
{"id":"8459a518-fe9c-4a4d-bb71-292e69afc30e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1689","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:51c08cff-afa2-400e-8a35-164527457265","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1689","original_object":"UniProtKB:P41146"}
{"id":"73868f77-546f-4ba6-94e5-3f87faa51068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231416","predicate":"biolink:affects","object":"NCBIGene:12802","sources":[{"id":"urn:uuid:463a8eca-b432-4b3a-9208-a272983f600b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9257","original_object":"UniProtKB:P47936"}
{"id":"f0d49ba3-6a88-4bfa-8f5e-f1a5a7112373","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5630","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:656fe4dc-9f2b-4e63-992a-9d841b0e5341","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5630","original_object":"UniProtKB:P30874"}
{"id":"87321175-394e-45c7-9407-a54aa75d3616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14533720","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:3660f484-1f09-4cf3-8695-2eca59e38707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6","original_object":"UniProtKB:P08908"}
{"id":"b49c2275-fa3d-44ba-9a8e-454c06e5d328","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162435223","predicate":"biolink:affects","object":"NCBIGene:1457","sources":[{"id":"urn:uuid:c56b4c7d-bbd7-4a94-9b8e-4f6fe14bf556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13949","original_object":"UniProtKB:P68400"}
{"id":"f9d8c270-678a-4952-8642-f6cb770e6f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11757797","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:cc2e49f7-ad70-4678-90cd-1bedbf6b1005","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:292","original_object":"UniProtKB:P08912"}
{"id":"79efb02d-6047-48f7-ba68-c0275cc031fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:4299d711-4f75-4d53-a817-0db4685dbb92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:O95977"}
{"id":"8fc59ece-ce2a-4652-8b40-5be65f994b65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:c5970234-0e21-4622-ae47-77470a0b42ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P17948"}
{"id":"12877c88-5494-4dc1-92dd-325036636fa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131345","predicate":"biolink:affects","object":"UniProtKB:Q9JIS7","sources":[{"id":"urn:uuid:04533ff6-fbc6-4acc-b952-538caa643738","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2511","original_object":"UniProtKB:Q9JIS7"}
{"id":"417a3527-958a-4804-86d4-954d82db39fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:29465","sources":[{"id":"urn:uuid:02cad86c-fcfe-4328-bcbd-e1bf8d0bc9ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9WUD2"}
{"id":"11a64133-f920-4d7e-bedd-58869295e653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:cabedb13-e1a0-4607-9dec-73eb5e09a2a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P43116"}
{"id":"0eefd756-4c41-4993-81e6-ddea3ff24e0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9C8MNF7CA","predicate":"biolink:affects","object":"NCBIGene:24890","sources":[{"id":"urn:uuid:aeaf5d90-6d3b-4cbc-90e1-046934b22a2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6700","original_object":"UniProtKB:P06211"}
{"id":"36bffea9-3fe1-4385-80bb-0d37364549fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16125102","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:dd4f2969-20e8-42df-a2e0-b1335def3d07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4123","original_object":"UniProtKB:P39086"}
{"id":"3f80f35f-9e37-4e15-9383-a7149db65636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131345","predicate":"biolink:affects","object":"NCBIGene:12292","sources":[{"id":"urn:uuid:f1f38bf0-7593-4bee-bf55-d820ffb4fdfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2511","original_object":"UniProtKB:Q02789"}
{"id":"e8196438-e2f5-49e9-8623-f2f610901ace","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:1e2e958c-1ca7-4740-be13-9eb6c76f226b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q15413"}
{"id":"90679e26-e8d5-445e-9dc0-7ba1955a91dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:d7b93f45-9afc-4ca1-9611-1f774f130597","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:P42336"}
{"id":"ea10736b-e5e2-40e9-ad2d-922f8a2116c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13316","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:358dc075-973f-4efb-8b4e-676bdbe53338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13316","original_object":"UniProtKB:P43220"}
{"id":"44e5459a-8107-49ea-80a0-e6c30609cf1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59397065","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:17a5d10e-58fc-478b-bb17-a91dd191c533","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8071","original_object":"UniProtKB:Q16288"}
{"id":"72d168a0-724d-4395-b419-c0f0aa750952","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:617","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:5dc866a3-eeac-4a56-a2e0-68590dd57063","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:617","original_object":"UniProtKB:P52500"}
{"id":"1e17a374-63fd-4c1d-ac06-6b4694fef80d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:87056189","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:9ba9f9f9-a039-4cd3-b458-83ff85463f5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12207","original_object":"UniProtKB:P49682"}
{"id":"d2fec0fb-c422-4bea-a38c-d1fda1fedffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3881","predicate":"biolink:affects","object":"NCBIGene:25007","sources":[{"id":"urn:uuid:5b4e9cd0-b95e-4f28-9752-7d389f37e7b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3881","original_object":"UniProtKB:P16610"}
{"id":"9f1551f1-7aa5-442d-b818-d784b1ff931a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5895","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:04cbcb63-e8dc-4675-950e-d9c1b6aa15d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5895","original_object":"UniProtKB:Q96P65"}
{"id":"676d6d7d-dfb2-4abf-bca2-10d5c5fd9f97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71283262","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:928b11f1-1ef3-4f1d-a2d6-4002462b31f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10498","original_object":"UniProtKB:Q13464"}
{"id":"9d72d858-5858-4918-a9be-4ca69eccc92c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311130","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:858775df-75d5-4b98-b035-6502bd84efae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:69","original_object":"UniProtKB:P08908"}
{"id":"e59d639c-f1bf-4afc-8c9c-5a40e4b556cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1023","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:9cd2dd6f-8dc1-40dd-9c44-155c800fb14b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1023","original_object":"UniProtKB:P25089"}
{"id":"8cddb69d-c9be-4f65-983e-6e9950b31121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147075611","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:5e5eeb85-1f9c-4dee-be11-1923f64caf5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12643","original_object":"UniProtKB:Q99250"}
{"id":"fac35b5c-a04d-4dc8-aaf2-d10e7da592fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130276131","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:666eec77-f649-4ec9-bb57-d2846dd02811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9690","original_object":"UniProtKB:Q9NR97"}
{"id":"a23d2f2c-f443-46a1-b9b4-ab2bcc3268f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45263310","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:a1401361-2108-47be-a289-51de7a159c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6733","original_object":"UniProtKB:P17764"}
{"id":"d98774f8-73b6-4ef0-9e6c-e9c4a2165b76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5353264","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:52141fc7-cd61-450d-86f3-f1a2b2b1d294","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2436","original_object":"UniProtKB:Q9Y210"}
{"id":"019d3ef0-d81d-4862-9063-e12b64b36ebb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:855c3741-1605-4f61-91c3-73585d7ec328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P51582"}
{"id":"c28d2f6c-999d-4d61-a9ba-93f58a5e39dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7633","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:b1bce851-12fe-4a68-8a9c-e0ad0d66601a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1630","original_object":"UniProtKB:P41143"}
{"id":"3e79ad55-a470-4723-88a6-25d7ff92a5f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1794","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:71e9a8d6-9fbd-45f9-8a3a-864775435b09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1794","original_object":"UniProtKB:Q03431"}
{"id":"fa7ef584-e770-44e6-8068-c0554579bdb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:47343202-6389-4543-a9eb-267aa4f5fabd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P41143"}
{"id":"93675735-8823-4aac-a8a4-edc264234fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134128280","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:62f24ea2-42c5-40e0-afec-6c28d699858e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10183","original_object":"UniProtKB:Q13164"}
{"id":"5570f1ab-d686-408a-a529-fa150dba0b91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44309215","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:3e4a2bb8-8a19-4d36-89c5-276ac11ffc5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1635","original_object":"UniProtKB:P41143"}
{"id":"9f45f441-60be-4019-b627-d491741015f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:a93d4bed-1fcb-4ce4-8e27-367cb917b5bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:Q15858"}
{"id":"91b43fbe-62b5-48ef-94d9-29ee764493f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135761798","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:66ae1889-6825-477e-bd4a-58a76cbffdf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8218","original_object":"UniProtKB:P49336"}
{"id":"4bfe7cb2-9cc7-401b-b67f-f50c13e4c190","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135018","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:a788d444-7338-4ba7-9d54-d822b4452ea3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1610","original_object":"UniProtKB:P33534"}
{"id":"57429b4b-f020-4cea-a6ad-16bda4925a47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035974","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:b9d47b9a-3f4a-4848-bd1a-c3e06c9726c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4243","original_object":"UniProtKB:Q14957"}
{"id":"a9abc3a8-9eb6-4563-9802-6de26c677d38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:838dc95a-749d-4170-b207-269ddf6234b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:Q05655"}
{"id":"6621f379-0fea-43ad-ab55-c3f1c67261d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2615","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:46629e3d-049e-4a33-b7d5-160ec3cb6f36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2615","original_object":"UniProtKB:P35498"}
{"id":"8252c1cb-1cd1-42dc-b7dd-e0c9f6d5b512","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3N422P20J8","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:0e04ad8a-204b-4dcf-b0ac-21086819c1b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4368","original_object":"UniProtKB:P47869"}
{"id":"53779f2b-1929-4b83-b819-8ca0e6532595","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:ef874437-e189-45b3-9bb4-b7aa179c1f4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P08908"}
{"id":"8261cc53-3f7b-454b-9acc-447c49d2d67c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130345035","predicate":"biolink:affects","object":"NCBIGene:4017","sources":[{"id":"urn:uuid:339d6668-ed06-4fc5-bdf6-ab8e121b9b54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10485","original_object":"UniProtKB:Q9Y4K0"}
{"id":"f14ff706-1aa4-4054-96e7-c568a83270ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2028","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:fd35ee3e-0b16-4390-a860-c2f03a596bcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2028","original_object":"UniProtKB:P32745"}
{"id":"40c46f4e-b8ee-428f-998e-0bb5103c1b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8346","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:5519a4f0-80a4-4430-bce3-b6c1975b3308","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8346","original_object":"UniProtKB:Q9HBX9"}
{"id":"21c6fa96-48a2-4581-9e0d-7f06c0799064","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5461879","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:07ef8d13-1211-4d51-b515-cb6e9d2d0b68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5603","original_object":"UniProtKB:P30542"}
{"id":"4a3f02a7-f6e0-490e-adda-174eac5c27ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:29a9f2d6-aafe-4179-a522-12323be7dab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P09619"}
{"id":"dbfac09e-7df1-48b4-81aa-31dc0cef93dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92418","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:d5d016e6-9422-4d05-a666-f06c5612966a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:295","original_object":"UniProtKB:P08173"}
{"id":"5e80d810-ec1f-4d53-a8b0-e1c983d786a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90668081","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:21662a8a-6f12-40f0-9aba-ad12bbf9d61f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8197","original_object":"UniProtKB:O75116"}
{"id":"4994287c-2627-4617-9c3a-02a7a7940c6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121881","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:4665a734-41e4-4724-9865-45aec935f82c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:256","original_object":"UniProtKB:Q62758"}
{"id":"8b362af0-d719-4e8a-ac82-4e84d3fd8870","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310992","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:ff449d8b-f604-4f57-8953-2472bb7147f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:416","original_object":"UniProtKB:P29274"}
{"id":"479c61c4-ded2-40fc-8fc7-e62b223a4dab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232377","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:9d845e37-f4e3-4210-81bc-fa9b444d9642","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1070","original_object":"UniProtKB:Q9Z0U4"}
{"id":"edb956f7-d17f-4c64-9ec5-9282cc6c3f84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118417573","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:f452104a-2ab4-4d52-88a4-b91e2eb041fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11115","original_object":"UniProtKB:Q13822"}
{"id":"af460604-01b5-4f18-9d15-ac972ec6fcd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TN7CUD1NGA","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:296e2ac3-9dee-418d-91e3-400572dd8f81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11414","original_object":"UniProtKB:P21802"}
{"id":"1d426e8c-8290-4d94-adb0-d200f5811982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71770951","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:22bedbe8-10c7-4844-8eda-f77d82e6eaeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10442","original_object":"UniProtKB:Q96RI0"}
{"id":"eb908080-c4c8-426f-b2c8-3f0c6f90b02e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165135384","predicate":"biolink:affects","object":"NCBIGene:7398","sources":[{"id":"urn:uuid:7574a4c7-1f4f-433a-b1ec-30520b8893ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13296","original_object":"UniProtKB:O94782"}
{"id":"55f99a5c-723d-4f2f-b5ac-aec466935947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73774630","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:5079eaee-9c8e-4978-8a0a-33acd9bd3b28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12301","original_object":"UniProtKB:P08173"}
{"id":"48c3dd18-8dfa-4e82-a7f7-24449db286cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10100","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:e8c4e197-ef1c-4adf-99af-73fc2d675c8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3322","original_object":"UniProtKB:P34913"}
{"id":"c00de4f2-6bfb-4cc1-b9ab-559b95146c0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110176","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:099b088e-308d-446b-8667-772f99ca2b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3264","original_object":"UniProtKB:P08172"}
{"id":"0d96e1bc-414e-4f52-a7c1-e452a41f2c5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:ce35360e-bcdf-461c-9ba7-88e3ef50e9c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9P0L9"}
{"id":"4e40309e-4536-4893-bff6-3935d5b376af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:836","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:deddd093-9589-49b2-a79e-f49d4b14872f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:836","original_object":"UniProtKB:P49682"}
{"id":"c436aa5a-0f21-47f5-b1f6-a72b8f8f4c98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58118983","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:19d6181f-ae67-420e-a01b-f70f04074d58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9858","original_object":"UniProtKB:Q14524"}
{"id":"71ba6bfe-b8d6-4564-94d1-df9939acde6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6906","predicate":"biolink:affects","object":"NCBIGene:24182","sources":[{"id":"urn:uuid:d8137040-3f22-4131-81de-988bb68d090c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6906","original_object":"UniProtKB:P35351"}
{"id":"069eb29f-ba71-48c8-a997-3616f9aa1d07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11176403","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:db35f6fa-d445-41e5-aa98-0ce150442054","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2900","original_object":"UniProtKB:P61073"}
{"id":"7a998987-d2a0-44fe-b6e9-5806bfd10fb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229242","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:74c8a738-2154-4376-8cfb-6f84504c90fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4027","original_object":"UniProtKB:Q8TDV5"}
{"id":"095119b0-6a7b-44a4-8eee-17c81ea8d48e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:a2975d22-1353-400c-8e32-5a2150c6c66f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P30557"}
{"id":"42d1944b-9f83-4a68-9673-cf774c1cd81c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZK5NA2M82J","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:001d1982-544c-4f4f-84e6-52baa96d17db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4299","original_object":"UniProtKB:P34903"}
{"id":"85d7d6dc-f52e-41ec-9278-26e6dd21f82a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699451","predicate":"biolink:affects","object":"NCBIGene:54301","sources":[{"id":"urn:uuid:05975922-cd44-462f-a31a-558a0a66420f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11156","original_object":"UniProtKB:P97689"}
{"id":"9a459500-e658-41e0-8afb-8a51277f2d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5290962","predicate":"biolink:affects","object":"NCBIGene:10765","sources":[{"id":"urn:uuid:324a6c57-3d11-44e1-876c-09d89a655535","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10083","original_object":"UniProtKB:Q9UGL1"}
{"id":"1aca56ef-aa49-437a-aa19-524e1f0dec1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:619d8e2a-fa09-4bc0-9131-6ed8b1f45710","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q8WUI4"}
{"id":"b6cd7701-a3d6-4a17-850f-bac66b7c8f67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132082","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:b4729ead-3055-49c3-962b-aeb993c60222","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7007","original_object":"UniProtKB:Q13547"}
{"id":"7a4ebc00-5f68-4bf6-8d8a-74aceca982ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9843120","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:d2543649-2072-443e-b51e-dd667ee2797f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:472","original_object":"UniProtKB:P0DMS8"}
{"id":"bc8c01e4-feb9-4933-a3c5-7811862127dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85078","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:2a609b8e-aab7-44e8-b619-df9899555163","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4594","original_object":"UniProtKB:P31639"}
{"id":"9488fcec-234e-4cc4-8663-3f15f4cb69f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755023","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:31fd1aba-4dc2-4ba2-9575-b53cc340b960","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1981","original_object":"UniProtKB:P21731"}
{"id":"843867fa-8a1b-4f72-993c-260d2a825cfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:8f580fd7-7bd8-49c1-b688-03d7f5775b40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:O00329"}
{"id":"2ff98c18-df0a-45f2-b292-694badb43e9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2222","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:0fac1fad-cb37-4acc-9a98-60464fb8c6aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2222","original_object":"UniProtKB:P30518"}
{"id":"2ada50e9-3e60-43bd-bb30-b8fec50c1f38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90448438","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:b50f2402-8b38-49c5-ab4f-cd7cdf254ef5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10089","original_object":"UniProtKB:O43353"}
{"id":"713307b1-8be3-4140-9150-f5ee298149bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73295","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:905f5aec-90d4-48cf-842a-09fa66e252ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:733","original_object":"UniProtKB:P34972"}
{"id":"6c82d3ad-05f2-41d3-a3ba-a45769855a75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817476","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:1242585c-9b00-41b3-b12c-ea784bf004e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5390","original_object":"UniProtKB:P56479"}
{"id":"4848bcb2-7293-4171-9d3f-28d55b60fee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54673648","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:5ff8a967-f42b-4118-bac8-cc1925ee6ba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11343","original_object":"UniProtKB:Q99720"}
{"id":"23dd55df-2c8b-4617-8889-4504b76bbf6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138993662","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:71251f56-d090-4e64-b604-9982500d2954","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10666","original_object":"UniProtKB:P48039"}
{"id":"24b99209-1674-4acb-b814-c49afcffa49d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LDR3USH1NJ","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:22e4d3e0-29f7-4d95-af4a-acab961988d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5612","original_object":"UniProtKB:P29275"}
{"id":"02b4b5bb-5075-40f5-a906-445f88ec96fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N65WC8PXDD","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:8a02bd7d-e087-491e-a61b-21eb9b53ca23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7729","original_object":"UniProtKB:P98170"}
{"id":"c108d8d6-3aa3-4c74-ac19-243d06bd4799","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92215","predicate":"biolink:affects","object":"NCBIGene:5152","sources":[{"id":"urn:uuid:94fc86fe-045a-487e-8305-0b70da266cb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2919","original_object":"UniProtKB:O76083"}
{"id":"b5482a6b-6994-4ea3-beba-a8d82b06a130","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4754","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:5496f652-7e61-4de8-a01e-c7cb05077e1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2446","original_object":"UniProtKB:O94759"}
{"id":"e028e9d6-5719-4939-bdb8-78ede16d7f52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2663","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:eca0d144-5df9-40da-9c8a-9ba35a47d65b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2566","original_object":"UniProtKB:P15389"}
{"id":"a04f9473-9f1b-41c6-a931-dd96bfb89ce9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91414","predicate":"biolink:affects","object":"NCBIGene:7465","sources":[{"id":"urn:uuid:3a96aa66-2a70-4246-95da-11a95867c421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7702","original_object":"UniProtKB:P30291"}
{"id":"72181f87-e269-47e4-97e0-4f2ba40c6043","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16566","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:38bd64df-6fda-4c59-8fbd-a6d011c6e9da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2453","original_object":"UniProtKB:Q9HCF6"}
{"id":"b92db9ec-1dfd-404c-8a9d-ba6bf9cb34c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46295","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:ca6fdd74-8558-4dd1-acbc-8098521a6369","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7320","original_object":"UniProtKB:O76074"}
{"id":"6697ce63-6eab-4101-872e-14b35321a286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8249","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:ea310272-1aca-43a8-837b-f8466e9782fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7273","original_object":"UniProtKB:P23219"}
{"id":"639d5e6f-f45b-457d-b885-4d85a46b193f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSL3FEZ1IF","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:c1a53166-0cbc-47eb-8f7c-cacbb6e605d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13108","original_object":"UniProtKB:P10415"}
{"id":"22476ea6-cf53-4032-95b9-e01230c89963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16393","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:d17d1d77-c78f-458e-8fa8-261911bccd20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2452","original_object":"UniProtKB:Q923J1"}
{"id":"edb8daea-9f78-4a58-8c56-c1552859c42f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8930","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:956e1972-011a-4cfd-b1db-436f4aafa708","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8930","original_object":"UniProtKB:P21860"}
{"id":"dc8565f2-0fdd-40de-89e1-a05856bbc258","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:c31ece56-abd3-4fc5-bfeb-c6446f536895","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2439","original_object":"UniProtKB:P35523"}
{"id":"4ae5e0c9-3ef7-4b78-b4f8-980edecfc7ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911338","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:2fef5c69-7e9f-4e9b-a1d6-38e914034799","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10437","original_object":"UniProtKB:Q13464"}
{"id":"74fd9c45-8521-429c-8cea-376a80ec3393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:871ba59b-ff4d-4dff-b872-71ba8a89e594","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P35346"}
{"id":"70ab58dd-0930-42e9-9460-3cca147f0ac9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:b20bee72-8e09-4c9d-bc9f-4f7acdf8ef09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P35367"}
{"id":"0d4a1886-3cad-42af-b03a-42ecf778cbc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58056092","predicate":"biolink:affects","object":"NCBIGene:3654","sources":[{"id":"urn:uuid:c5b5b382-6240-44e3-a215-bb0678aec5cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8085","original_object":"UniProtKB:P51617"}
{"id":"01fb3702-d9ba-4dc3-8192-4214441ab82e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94186","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:0646c88a-307c-4a0d-b35a-c0ecc460ebbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9702","original_object":"UniProtKB:Q9BY41"}
{"id":"c699e030-fea0-4fa4-b967-886919881c7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12969","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:fb4bcf0c-4e55-4bfa-ad6e-c81bf6b2f533","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12969","original_object":"UniProtKB:P07766"}
{"id":"713029aa-d0d2-4b89-8465-69e860e1d581","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34802","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:71c19e77-5948-48b6-9094-613c6d4c110a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4229","original_object":"UniProtKB:P48058"}
{"id":"00f12ead-9ad3-4bc7-b4a4-264d5e8b30fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15647","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:65eb6215-806c-4348-94a0-dc12778ab4cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2487","original_object":"UniProtKB:O35433"}
{"id":"5aaaf347-fd6e-4ec3-9b56-7e2860572f63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK43YC00I7","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:91a59ae6-e5bb-4b7d-8a46-5caead8b4c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:183","original_object":"UniProtKB:P30994"}
{"id":"35018d2e-11c0-445a-a9fb-c513190c33b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F197218T99","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:9871c1f5-abcb-47b3-bd3f-8070eb59d40c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12755","original_object":"UniProtKB:O35433"}
{"id":"7d217e00-302b-4638-aa99-97e45057c477","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358780","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:e43f8fc0-f02c-4d47-a53e-efcfd0adb6c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11971","original_object":"UniProtKB:P0DTD8"}
{"id":"61080027-8f26-4b34-be87-5a604052f820","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131169","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:5f030525-fb16-4dd1-9c89-b796f375a55e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7795","original_object":"UniProtKB:P42338"}
{"id":"77eda865-4dd2-421c-99b5-63b2c1afe20a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3165","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:9c44880b-3d0c-4c21-9ed5-cf6ea1b8d973","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:649","original_object":"UniProtKB:P30411"}
{"id":"5fd10cc2-9f36-41bc-b308-36342c042cb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817397","predicate":"biolink:affects","object":"NCBIGene:60432","sources":[{"id":"urn:uuid:9777355d-99e4-41af-bea7-f3324655517c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1145","original_object":"UniProtKB:Q9Z0W0"}
{"id":"cb594425-95b0-4f8e-b9ba-c7aa14929a6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4160662","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:49418974-6de3-4ec1-8cd3-f72d7faffb52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10063","original_object":"UniProtKB:P49336"}
{"id":"82b198b6-6ec8-4a12-b657-0185b02c3a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7220","sources":[{"id":"urn:uuid:a22c63b4-8b42-4c3b-9600-8122e6c60e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:P48995"}
{"id":"c7f0ad74-5e61-4b4e-bd35-29655fbe3c82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:9265d1ba-4ce7-426f-95e5-dbaaa77b1349","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:342","original_object":"UniProtKB:P08172"}
{"id":"7b255a3f-ed7e-4de8-8445-09c1f3cfb9ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56589615","predicate":"biolink:affects","object":"NCBIGene:4056","sources":[{"id":"urn:uuid:cd65f411-ec8c-493f-a611-c1fea96ee70e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8875","original_object":"UniProtKB:Q16873"}
{"id":"03591a01-c18c-43bb-8a97-01b66e72a889","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135929","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:1580f9f9-4159-4f5c-9a64-f54165c17c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:493","original_object":"UniProtKB:P35368"}
{"id":"90a962b3-eae6-4f50-bf1a-068d74bcf564","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:a56718b9-ab29-44b5-a16b-a01bbef61907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:Q14164"}
{"id":"45b912e4-9bd7-4a00-ad9f-167bbdde5da3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1511","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:4b625e35-ac35-4700-8714-b3416eb85dc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1511","original_object":"UniProtKB:P21555"}
{"id":"1534f8f1-f45c-4b6b-9e1a-c67fe04f6074","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:10804","sources":[{"id":"urn:uuid:c223b83d-c5ff-4549-8788-4e64a22e7afa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:O95452"}
{"id":"53511b8b-c0bd-4895-9b0e-41d001540061","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:d636b591-3c19-48ec-91bb-b345f5faff53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q92769"}
{"id":"ae54520c-9e7a-41f0-9da9-edb9f7ffa11a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827359","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:8b9ef66b-45a2-4acc-bec0-3524a8ac490e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8419","original_object":"UniProtKB:P30542"}
{"id":"ad59c833-612e-488d-bf03-6d319ccb2049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54761306","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:dd070185-c873-47bd-8e0a-fb27d34d5f66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9390","original_object":"UniProtKB:Q13535"}
{"id":"cec06974-462c-4ab6-883d-7a0965a6a0cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18397","predicate":"biolink:affects","object":"NCBIGene:294122","sources":[{"id":"urn:uuid:9e684081-d6c1-49f4-b8c7-34babbe01b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2144","original_object":"UniProtKB:Q923Y7"}
{"id":"b1ec78fb-d1ed-4cef-8771-fc3e00c9fff3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94186","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:dd305d70-d537-4e22-9f39-99bd583b3760","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9702","original_object":"UniProtKB:Q9UBN7"}
{"id":"0427cb73-1799-4e81-bb5e-b42f1f7e0aae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3V574S89E1","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:332ee582-6a9b-4066-89f0-5322e6ff577c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1","original_object":"UniProtKB:P08908"}
{"id":"c9501c41-fa5b-4dbd-bb15-0095c4a645d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:3bd36f91-86c7-47f6-a82d-5da426771c4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P34903"}
{"id":"5dec5f87-6dd4-45d3-8d8c-1cf7af41bcfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:65195","sources":[{"id":"urn:uuid:063df1a8-1b6c-4f78-b96f-1adc5632e6de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q62897"}
{"id":"349267c2-0833-4ef3-811d-962555168d4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94329","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8629924f-3024-4a28-b350-4a8714c2a32e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7257","original_object":"UniProtKB:P08173"}
{"id":"606bffdb-7eaa-4b91-a65d-7af09db5434b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53115","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:b3b4405a-f623-4384-add2-0862c293f69e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5609","original_object":"UniProtKB:P25099"}
{"id":"aa8ffc33-d4cb-4366-9327-df8aa91a7b01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:49137e56-fe6a-4b66-8bd3-2159086d94ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P18089"}
{"id":"b6617837-57bd-447e-ab69-81b71896e642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16496","predicate":"biolink:affects","object":"NCBIGene:18171","sources":[{"id":"urn:uuid:032805af-a188-4180-850f-8c9306730f4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2803","original_object":"UniProtKB:O54915"}
{"id":"9be946bd-d8b0-4aa3-82cd-17d3be2c4f15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:86a6ed3c-f8ec-4ee6-b08d-477cd4486fcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:P17948"}
{"id":"1ca017d1-d2f0-412c-bad6-fd15689e024f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3467","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:7af2ec93-7f8a-422a-87f3-40ca6e7f0f50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2427","original_object":"UniProtKB:Q9NQA5"}
{"id":"cabc139e-e8d5-42fa-b86f-35c0c95fe545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755085","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:512a10a0-5e2b-4a7c-ba4a-f4cad0f719fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4201","original_object":"UniProtKB:P23416"}
{"id":"e87ad6ea-b144-4e85-bd08-c853d82388e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:3a75f034-69ba-428c-aa09-f347acbb7865","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P17948"}
{"id":"44b3791c-cf82-400f-8607-8b5feecfbdce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1798","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:8f62cd6a-fd63-40c3-bf31-d23e944c13b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1798","original_object":"UniProtKB:Q03431"}
{"id":"07e6a8c7-ccc3-4d34-91b5-2d1a286949ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94490","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:ba64f62d-47d4-4b6e-aa63-8124d1ffa556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7937","original_object":"UniProtKB:O14965"}
{"id":"8143ac1e-5d93-45b7-a9af-a9686e6b3e71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422756","predicate":"biolink:affects","object":"NCBIGene:7486","sources":[{"id":"urn:uuid:7da4ed03-18f3-48a6-acb8-0b82a9ef13f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13023","original_object":"UniProtKB:Q14191"}
{"id":"159e6cf7-f9cd-43b2-b6d0-57a4a9faf9da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603801","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:e790d69c-780b-46e4-9f6e-47969ca9783b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:153","original_object":"UniProtKB:P41595"}
{"id":"63f90476-8864-4e8e-b413-7a8c09e3d8c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93452","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:33abbdbb-8599-4e19-98ee-0598720d8e79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4296","original_object":"UniProtKB:P48169"}
{"id":"6449e1ce-2a1e-42a0-8048-568db2f3fa5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:406401","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:a130d8f7-ffea-48a7-bc93-b7ecf8eb7748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3160","original_object":"UniProtKB:P14324"}
{"id":"00139523-0957-436e-82eb-6e9b2b82f154","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44392528","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:45420a4e-e448-4c79-9ed0-91a71d843bd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2985","original_object":"UniProtKB:P51639"}
{"id":"628335c8-99ab-46ff-aa17-5e377419e502","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5900","predicate":"biolink:affects","object":"NCBIGene:170641","sources":[{"id":"urn:uuid:c1743cb9-50e3-4b5a-bcb0-1661ca703671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5900","original_object":"UniProtKB:Q9Z173"}
{"id":"d6d56e8c-8135-4f20-9470-fb21946b798d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433303","predicate":"biolink:affects","object":"NCBIGene:2879","sources":[{"id":"urn:uuid:bb85f18d-636c-46b2-9b03-213036b8782d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12799","original_object":"UniProtKB:P36969"}
{"id":"cac97fdd-3e6d-436c-be28-2171a5fb17dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10281725","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:747cf17c-c0b9-4752-8959-acdfbf37f91c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:666","original_object":"UniProtKB:P97583"}
{"id":"55a02ebc-0323-42ee-9af1-a1ee4044e4b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:41b272ad-28bb-417a-8c43-8f299194e3f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q7RTT9"}
{"id":"5ab4113f-d030-4c6b-80be-813d87b84d14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IA262432Y9","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:0fd43dc3-efb9-47ea-ae6f-790715c3f5ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4304","original_object":"UniProtKB:P42262"}
{"id":"9e88bfd5-5566-4d28-acd7-45db764c5e80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368928","predicate":"biolink:affects","object":"NCBIGene:10273","sources":[{"id":"urn:uuid:700c873f-3339-42e8-b225-1cdbd22b3a04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12063","original_object":"UniProtKB:Q9UNE7"}
{"id":"123ead42-6761-4dca-80cb-54de33da1622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311453","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:c9c83615-b7cf-4380-9347-85a20c668965","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1939","original_object":"UniProtKB:P30557"}
{"id":"59f45c9b-9da9-47ef-8477-b347fcbcf857","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:19411","sources":[{"id":"urn:uuid:2ded56b8-ba84-4bc5-bdf8-9c537961cc4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5383","original_object":"UniProtKB:P18911"}
{"id":"7a286979-c2ce-4633-acd4-e6f375dac66a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PH9ZB6IRW0","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:757b982b-64dc-4cf9-9e65-ad4ef31ed8e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5788","original_object":"UniProtKB:Q8TDS4"}
{"id":"5e4d299d-f752-4716-89ce-4662bda8c0b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GE2T1418SV","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:3d473390-4b3d-4526-9866-65abae33bb97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7354","original_object":"UniProtKB:P20309"}
{"id":"986b490f-1ec6-4352-8c4c-a3402bcc59c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:7652a59e-d7d9-4de5-8fd8-1ae03c444de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:Q00535"}
{"id":"c4cb3c71-1fbb-4f99-a24a-0a5f328f597d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072557","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:9e701254-2646-4d3c-81c5-7c5eea16c678","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9000","original_object":"UniProtKB:P35354"}
{"id":"1813b166-779f-4cd8-a26f-76c949678006","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92113","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:9710e5b9-876d-460e-b2d4-63f934a0a9c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9741","original_object":"UniProtKB:Q9HC97"}
{"id":"d06ef4fe-258d-4558-b635-c8959ddb7330","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:440","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:23773a94-4429-43a1-91fe-3619ae39b105","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:440","original_object":"UniProtKB:P29275"}
{"id":"80994f7d-aaaf-48fb-ad3e-ef4b26535413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:61af8427-dc93-4785-b1e6-d2d19f3642c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P32215"}
{"id":"09ecbd96-8df3-4813-a938-d881fc510bd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154727580","predicate":"biolink:affects","object":"NCBIGene:199974","sources":[{"id":"urn:uuid:f40586e0-ad3c-43f1-8235-13d0b41337b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11374","original_object":"UniProtKB:Q86W10"}
{"id":"ba4ab08a-e4ee-499f-b2f7-7c3438a466d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60150550","predicate":"biolink:affects","object":"NCBIGene:8560","sources":[{"id":"urn:uuid:c94a812e-9242-4b78-bccb-f3ca1fbc0af9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8879","original_object":"UniProtKB:O15121"}
{"id":"1fc0d67f-d53e-417d-8477-32184abc70da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M18T0TD14","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:60b2f0e5-d115-4406-a7b7-b3cf10e41700","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1620","original_object":"UniProtKB:P34975"}
{"id":"e99fc7d5-a7b7-4956-970a-2fd28a448ae1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126970685","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:f1162b6c-836c-4ec9-9851-5221f642b03e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9579","original_object":"UniProtKB:Q14164"}
{"id":"fa537a47-4237-4a06-bbc3-e31dfc4eb18f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31401","predicate":"biolink:affects","object":"NCBIGene:5140","sources":[{"id":"urn:uuid:354fbba8-32da-41d6-977c-321a99cf30e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7148","original_object":"UniProtKB:Q13370"}
{"id":"0b23fb9d-df56-4594-8d27-5934f0f5320a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138424","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:2a2eecd3-7a99-46ee-9b5d-a82036c4f85a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2508","original_object":"UniProtKB:Q9Y210"}
{"id":"0e6085a7-c322-4f2b-ba5c-499e714cd830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1048","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:fd4598e3-3a66-476d-8e4e-46b643b6b536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1048","original_object":"UniProtKB:P25089"}
{"id":"a128ec41-067f-4771-8573-1d21253f67a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Z681APD51","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:b8b4bfbf-89d7-4b0c-bc2e-85b3584ce2f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1772","original_object":"UniProtKB:Q9H244"}
{"id":"ae196bfb-2941-4261-877d-01cc5e18621d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5583","sources":[{"id":"urn:uuid:41e05495-c647-4002-9914-82b5d11de56b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P24723"}
{"id":"a74233d4-5347-43fa-aef2-62cfb8d177f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71613550","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:47ea53ef-9284-4d9e-91ff-f9ac6e901914","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12380","original_object":"UniProtKB:P00533"}
{"id":"df93d013-714a-452a-a370-8d2ad39df0d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:b49f3280-2845-4aef-90d2-bd30f2e921fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P17948"}
{"id":"aaa2058a-ad95-46c0-8790-d41fd9387a93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94513","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:b6ac016b-b32a-46b7-95e3-bc19a4747547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6828","original_object":"UniProtKB:P00915"}
{"id":"f37578f4-6bd6-4585-a510-d0f3e28cf42b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38565","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:d0f3d116-e884-437f-ad8b-cea4ce114123","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2951","original_object":"UniProtKB:P51639"}
{"id":"2c5daab2-7e45-48e1-b5b8-a84900af4e6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6141","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:8c566525-7e4c-40e0-81ae-d85c67a405e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6141","original_object":"UniProtKB:O43603"}
{"id":"45240864-22a5-4235-bba1-e72131364140","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63610","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:f8484237-678e-4c3f-b1a6-0fa1cfa0e11a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1936","original_object":"UniProtKB:P43115"}
{"id":"c7fce9f6-49fb-42d6-b402-9f8054bc9042","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JJC99KHGL","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:07061309-0c9a-44ba-970d-ee168408babc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11118","original_object":"UniProtKB:P56524"}
{"id":"bdc987f8-032c-4bc9-8c52-9a8d6eca6606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16595","predicate":"biolink:affects","object":"NCBIGene:3709","sources":[{"id":"urn:uuid:ec7066f2-0471-4f2d-887d-85d85358c396","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4222","original_object":"UniProtKB:Q14571"}
{"id":"c2c083f9-dee0-488c-b9a5-bb847ff2df36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166560233","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:90f302f9-99c2-4d49-8452-c9e6f67414c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12392","original_object":"UniProtKB:P04629"}
{"id":"1bce85b8-75b6-40cd-828e-c674f809d1e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72323","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:23a93c76-e51c-4e8f-8689-ba478f25dea1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6319","original_object":"UniProtKB:P27487"}
{"id":"36590a89-3e08-4bc8-91dd-22ac86f5f439","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89576","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:72ac0761-41a5-4812-9416-0783a0367ef4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:265","original_object":"UniProtKB:P31388"}
{"id":"cc1d71d0-a77d-4e52-999e-abd1b8ab16e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32039","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:65ebc7de-1ff1-42f5-9097-6c6d09a74c81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:874","original_object":"UniProtKB:P30551"}
{"id":"e53a717b-8edb-4ac4-a38a-4cc78b8e92c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:920","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:1678ba88-697d-4399-b531-5439282c3f08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:920","original_object":"UniProtKB:Q13324"}
{"id":"94eef14d-1c33-450b-a7a8-f3a71fd0943a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2044","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:788902c9-4ff7-4977-8d79-5da7f9e2ba0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2044","original_object":"UniProtKB:P30874"}
{"id":"3974f114-af61-401b-b669-c43f6a4f94c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:7cb65a05-7c4d-4d22-8076-df185f8d0058","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:P31391"}
{"id":"808e1c0a-f3b4-4174-81b8-cde71de3978d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27662","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:3ae2502f-f1a7-4a11-aff6-222921c0608f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7124","original_object":"UniProtKB:P14416"}
{"id":"b66b3291-b5b1-4741-963f-ff5e8ee8a022","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2817201","predicate":"biolink:affects","object":"NCBIGene:290","sources":[{"id":"urn:uuid:9b820b25-07c3-42b4-89b8-021e1605a24f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9668","original_object":"UniProtKB:P15144"}
{"id":"b4c280ba-91a0-4673-af79-91f8ea28c378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164532637","predicate":"biolink:affects","object":"NCBIGene:2191","sources":[{"id":"urn:uuid:c2861295-bad6-4bc4-89d4-3f03633dc451","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13842","original_object":"UniProtKB:Q12884"}
{"id":"133cdcaa-b22f-4b93-b2c2-5bcae69820da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643159","predicate":"biolink:affects","object":"NCBIGene:171087","sources":[{"id":"urn:uuid:b44485ec-1a64-4f0b-9a97-c61d6bd61ad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11299","original_object":"UniProtKB:P63031"}
{"id":"10320c1e-6b78-40b5-a888-fd0812fce9f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:573747","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:feb13e8a-ea16-468a-996f-ec9a2eb2f598","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4212","original_object":"UniProtKB:Q8NEC5"}
{"id":"7651fa55-9401-4343-905c-bf80cb0e64b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132914","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:aa7d94f7-163f-492f-b253-43dce1758ec5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1162","original_object":"UniProtKB:P30969"}
{"id":"91e3f381-512c-46de-8ca5-b474b37055ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231350","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:a7f645db-2f7d-4220-8048-b5e9b02fd664","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7793","original_object":"UniProtKB:P52333"}
{"id":"cb33aa2d-bb76-410b-90ab-82ac522c7385","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91500","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:230441a2-82ee-4e02-a2b4-e8a2597f1b4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6037","original_object":"UniProtKB:O14757"}
{"id":"73b9bd26-1074-4fd9-bed6-8a0c991b9b7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101865250","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:422af393-dc88-405a-a291-127d2d8f39d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3906","original_object":"UniProtKB:P46663"}
{"id":"43a3f4c2-278b-4839-8ed1-ecd0c08d56a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135747628","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:72a82586-d6fd-4ac2-ae6c-ca922daf9b2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10195","original_object":"UniProtKB:P11309"}
{"id":"1d2c533e-aa53-4ad8-8524-edd97242020b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2024","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:0e1103a6-aee7-4fbb-ac5d-95cccea9115a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2024","original_object":"UniProtKB:P31391"}
{"id":"e26fac96-ca94-493b-89e1-94ab6e7e754a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53630410","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:4c210e7d-ad97-43fa-9f41-c2e7ef892d8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5739","original_object":"UniProtKB:Q8TDV5"}
{"id":"901b2c49-4ddd-4c88-8a06-a5053fd8c91f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311208","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c10db703-e66e-4abc-9223-5a1f2bbd2f5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1890","original_object":"UniProtKB:Q13258"}
{"id":"afd62775-5394-480c-a918-4f0cea155695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71952","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:1fd252f6-e866-406d-98e3-0cc09dc9d093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7950","original_object":"UniProtKB:P48736"}
{"id":"dab2b15f-b22e-4f66-88d1-17f1fdf6c4e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5138","predicate":"biolink:affects","object":"NCBIGene:25553","sources":[{"id":"urn:uuid:0f9973ce-2533-4ece-8af7-02d9d23136dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7189","original_object":"UniProtKB:P31652"}
{"id":"0bd939e8-8e1d-4079-aa6f-038ff754a5fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3X8387Q25N","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:51d2180c-3949-48d7-8787-854a7a5b239b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10459","original_object":"UniProtKB:O60674"}
{"id":"58a24510-f491-4d1e-8003-3a26021e86c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11755040","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:39740b25-e140-4acc-ab63-edadef9110e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8079","original_object":"UniProtKB:P19793"}
{"id":"3a7d5b80-a9e1-422e-bbda-2ddf5bdd0ebf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:d87846f6-2571-46a4-a93a-8f02d33d37fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P28221"}
{"id":"f0a1f1ee-9a40-42f2-a698-2836496b8a25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44328226","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:0e4cdfa5-6a6b-45d1-ba96-055598ad98ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1557","original_object":"UniProtKB:Q15761"}
{"id":"3428e9be-8062-437a-b5af-31225d905fb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:b5bf4107-cf4b-427d-8b6f-ef930f0b4a52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P31423"}
{"id":"e8f490fe-b7c9-4d4a-acf4-05ae1098867e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:2c946807-e1cc-4e3d-a2f7-f96ba06c4883","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P35375"}
{"id":"c25b9a44-d2e2-4960-8a2c-3ad05bae6d9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16049828","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:41f9fd63-74c6-48cb-ac6b-5d993f8c9c29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2129","original_object":"UniProtKB:P29371"}
{"id":"50946894-14c9-49f8-a724-8c089ab7f374","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72201027","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:0991d157-20e7-4061-8763-16ebe836a0fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7529","original_object":"UniProtKB:Q92793"}
{"id":"f7ebb382-7f13-4ae8-a14f-ed98fdf89bc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2545","predicate":"biolink:affects","object":"UniProtKB:P17659","sources":[{"id":"urn:uuid:9cbc1cee-4547-4579-a5fb-992580389fb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2545","original_object":"UniProtKB:P17659"}
{"id":"0de6537d-aedc-4768-947c-66df2d3f9a5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34076","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:8ffb30b6-0298-444b-b5cb-e641c2e9c8dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2314","original_object":"UniProtKB:Q9UGI6"}
{"id":"2ab30748-f1db-4ac5-974c-72f154715927","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155586901","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:7b39817d-8350-4f01-bf70-63bfc39022af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11526","original_object":"UniProtKB:P09874"}
{"id":"7e40523a-cfe4-409e-ace5-3dc04f575912","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081974","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:669e6630-77a7-460b-8675-74b2c070134e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9936","original_object":"UniProtKB:P14618"}
{"id":"f13c44c9-f251-46dc-a192-02c14ae2f4a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145428","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:267ebace-f402-4754-aeb3-b707e849db17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8201","original_object":"UniProtKB:Q99835"}
{"id":"9815acd7-ec74-43a2-8199-abfcee54aeb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56840673","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:9e6ba6bf-df96-4ca2-8dfa-84267adfe53d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8503","original_object":"UniProtKB:P32247"}
{"id":"bd719902-04bb-4c3c-8f29-9eec6dd98c6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1554","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:55db3c69-c069-4275-a4aa-bbb6c0813691","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1554","original_object":"UniProtKB:Q63634"}
{"id":"f00e8779-77b5-4734-bb1d-b0aa429d6df4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3654","predicate":"biolink:affects","object":"NCBIGene:1235","sources":[{"id":"urn:uuid:10933cac-13e3-4d91-8948-8985e8a8cdd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3654","original_object":"UniProtKB:P51684"}
{"id":"5d2964bf-3739-4448-a892-609bdc72f94e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34076","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:5ccbb834-b717-4768-b45d-21c621a33068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2314","original_object":"UniProtKB:O15554"}
{"id":"ca0c79b4-a7b6-4cb1-b7af-fdaa3134cdbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:127342","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:330192b7-d066-405d-a188-cab16e2813b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7118","original_object":"UniProtKB:P31645"}
{"id":"d35d818f-d46a-4507-9270-fec49bcf2674","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:441P620G3P","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:55ad843b-6a16-4a61-881c-9ba02c543205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9426","original_object":"UniProtKB:Q13547"}
{"id":"f5ea055a-65ce-486e-b5d1-94d9dd4fb8c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553173","predicate":"biolink:affects","object":"NCBIGene:7097","sources":[{"id":"urn:uuid:0bf93a6e-1ab7-4d2d-ab02-8bb281b868be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10341","original_object":"UniProtKB:O60603"}
{"id":"7244cf4d-17fe-43c6-a05e-73162c45ecc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:7a566020-5232-425a-b801-f8fc8c3d6874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P48169"}
{"id":"f396a0b2-e3f0-4211-ad0c-9663a2167de7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31205","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:3f7aa263-2af4-43c9-aaee-d11cac267817","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7113","original_object":"UniProtKB:Q14164"}
{"id":"c5d1b6bc-f402-4c72-8aa1-31d3ddfeda6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167507171","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:66e07d00-4620-4fa6-9e12-0aa2a9907582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13638","original_object":"UniProtKB:O14744"}
{"id":"ff8bef51-a016-4e80-8e25-389930207882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2560","sources":[{"id":"urn:uuid:6407b0d0-035e-49f6-a8e0-fe41c5291f09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P18505"}
{"id":"cd58debe-cc54-4a6c-bfe9-5108618fad50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946906","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:237d959b-1d6c-4cbb-b34a-8751ba1aa0fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12413","original_object":"UniProtKB:Q92847"}
{"id":"308b3ac0-ab10-4232-86b4-f66a5eed9982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7573","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:09dd0b87-386a-4f46-95c7-0789a4e5a577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2864","original_object":"UniProtKB:P10275"}
{"id":"ea01f117-a9a9-4e1d-9441-40e8ac7a81e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:5154e070-382b-4bc1-b7f6-2be0f8dc6378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P34969"}
{"id":"e19278d6-7fe2-43e7-948d-4d86bec7c408","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:e567c1d2-1329-4595-8920-924de49b3093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:P42345"}
{"id":"cba07834-48e1-4d86-b955-9002d5e96982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:171113","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:24a2ecbf-817b-44f4-9448-a2a995829d8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2180","original_object":"UniProtKB:P37288"}
{"id":"b3455708-ab7b-4aaf-8725-b63cbea9c6b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3N422P20J8","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:1d28f480-e87f-4ed9-932a-f4b19a440e4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4368","original_object":"UniProtKB:P48169"}
{"id":"d92d4bf9-371f-4d43-885c-071ef654e718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2167","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:d4562fe1-0256-4565-aa0b-05722a755356","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2167","original_object":"UniProtKB:Q9UKP6"}
{"id":"baf53bdf-0560-4b2d-9ede-be40f915f747","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:490561","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:85e30a3d-7162-441f-b265-e323ce6872f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:336","original_object":"UniProtKB:P11229"}
{"id":"77bb19d3-414d-438d-8648-454cb08492d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:74023","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:775ddc5a-0158-4d73-aaea-9d0d5e9dd5c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:840","original_object":"UniProtKB:P49682"}
{"id":"1bd93ddc-a76b-4136-a3da-42fd17f6ec79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312119","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:96c6fdc8-3b94-4820-a982-fac90e40e4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:680","original_object":"UniProtKB:P30411"}
{"id":"d9352f92-8cdf-40b4-8402-6a58768d85c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24824960","predicate":"biolink:affects","object":"NCBIGene:602","sources":[{"id":"urn:uuid:b5ed7865-c428-4ca0-a10f-4d30607d4957","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12672","original_object":"UniProtKB:P20749"}
{"id":"a7b01101-0bd1-45e4-9df9-81760654a7e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146502834","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:1a50e419-44eb-4a2c-9a7d-77f94d120534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13068","original_object":"UniProtKB:P50750"}
{"id":"a5475248-35d1-4918-8b4a-003bfed52449","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XK5ILZ28KI","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:27dc7804-3a0d-40e2-a6d5-45bf640d4dad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10452","original_object":"UniProtKB:P35372"}
{"id":"c26671ea-4160-4935-9b6d-beb2b0e5d5c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PW3Q92Z6A4","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:9944df56-5274-4f58-9d22-2b8acfa42c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11624","original_object":"UniProtKB:P30530"}
{"id":"4585001f-b342-44e2-8b56-8ecb668ba394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79988","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:cbbc3673-cdcc-4b01-b51e-85332e5d057d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2639","original_object":"UniProtKB:P10827"}
{"id":"ae1fe158-a9cc-464f-b640-e1993d4ebf80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49668","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:f7942281-d01f-4666-bfd9-d7bb1e1a3274","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4941","original_object":"UniProtKB:P00533"}
{"id":"cb2668f5-6636-4045-8a23-154bf0063c2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94998","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:74819980-5ddb-4d5e-b9ab-a815688c6130","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10971","original_object":"UniProtKB:P25116"}
{"id":"2ba93cf4-713e-4a72-a54f-741d0ad3a8f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:193034","sources":[{"id":"urn:uuid:71769d0f-ab2b-41f4-bca2-087cbdd46a4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2491","original_object":"UniProtKB:Q704Y3"}
{"id":"d8441f7d-3244-4f25-afd1-73943e6b0a89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11245287","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:145a0a0c-40aa-41a9-81fb-35bf9589419f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6363","original_object":"UniProtKB:Q13255"}
{"id":"4edc63e0-27ba-48b3-96f6-a340f14b6498","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1321","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:775ffed5-160c-4fb5-90d0-1d92d6798ee0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1321","original_object":"UniProtKB:P32245"}
{"id":"e9d65e0d-4f7c-4200-ac92-7913969653d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32010","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:46fe9642-f1f6-4b8c-a70e-85d5758b1b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4288","original_object":"UniProtKB:P42262"}
{"id":"95020180-cf8d-4274-8d86-fa725579b1a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HOU4I0G29C","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:b096eab3-f643-4e0c-885b-49668b8fa6f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:887","original_object":"UniProtKB:P30551"}
{"id":"7d8d5517-bf2e-4191-aa53-f8cdb8bc1008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L1E28E0J8F","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:f7fc2ae9-2741-4248-aa03-3fdaee22ee03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5861","original_object":"UniProtKB:Q9Y271"}
{"id":"51ff94fa-2a6a-4f54-a577-45e2d497c697","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1498","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:b03afa1f-d18f-4785-8c93-d6832a998f54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1498","original_object":"UniProtKB:P48145"}
{"id":"dafd9698-4972-4847-a5e2-d2ea0a11b4f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16019476","predicate":"biolink:affects","object":"NCBIGene:108052","sources":[{"id":"urn:uuid:026f8a03-65f6-4474-9b88-f0d40f718e11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8881","original_object":"UniProtKB:Q8VHL0"}
{"id":"8bb3410b-1591-4055-a6f1-1df52fc0a309","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2274","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:95913720-09c4-4c48-b589-07372de19490","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2274","original_object":"UniProtKB:P32241"}
{"id":"54822adc-2f6a-4d83-a369-b93971e391ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28865","predicate":"biolink:affects","object":"NCBIGene:53919","sources":[{"id":"urn:uuid:9bf01175-ee07-41ed-b357-176a9fdfaa72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4547","original_object":"UniProtKB:Q9NYB5"}
{"id":"5abde8e6-6a9d-4617-baf2-95e21b0e71d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51368","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:6d627aab-9bd7-4c06-982b-4012d1234582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9868","original_object":"UniProtKB:P18825"}
{"id":"c04072b9-37a8-4630-8d08-82375ea0875f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71506845","predicate":"biolink:affects","object":"NCBIGene:23678","sources":[{"id":"urn:uuid:4b90abb8-4380-409b-be2f-b91b23ed5e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9423","original_object":"UniProtKB:Q96BR1"}
{"id":"0b5d447a-cbf8-470b-aef5-46397e36a7cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7T1PY32ZPH","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:fde70059-ab36-423f-a17d-96e44a3fefa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12620","original_object":"UniProtKB:Q13627"}
{"id":"5f2b0eef-1fbd-4210-a279-fb84dbe353f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:02d69ac4-839a-4890-bb90-9bb97152d1e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P48736"}
{"id":"fc999569-e914-41b0-a53f-3fd0dd0abe00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11610682","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:cb1195f2-267e-46e0-8a36-79a7c573cfaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6403","original_object":"UniProtKB:P31424"}
{"id":"306e0f5e-cf5e-4d91-b17c-ac88721a8911","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10389239","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:7108ce06-7823-402e-b747-0580fdab220b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8177","original_object":"UniProtKB:P49137"}
{"id":"0672aa97-2c98-430f-9327-70eeae579b69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75451","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:ccdffce0-8a95-4017-9ee3-371f40e85cdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8411","original_object":"UniProtKB:P32239"}
{"id":"1ef27556-4424-4eca-a7d9-235982703c40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142290","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:3ca9aa55-8ead-4830-a1a6-44500f1bb517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7114","original_object":"UniProtKB:Q14432"}
{"id":"389b89fe-f383-4cbd-87c7-81845e6b3f6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3723","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:0f8d6b69-ab50-4892-a097-e477a316ef77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7547","original_object":"UniProtKB:P23975"}
{"id":"73448c04-5b5c-45b0-be37-9f9954dc5c8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45FRJ4YGM2","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:be04b87b-138a-432b-b990-32eef3e28593","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11693","original_object":"UniProtKB:P21554"}
{"id":"9a88743b-8ade-4731-88bd-309004a5529d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13878027","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:522d4035-304e-478c-b736-5ae63d7cecf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:179","original_object":"UniProtKB:P14842"}
{"id":"3c154391-7b54-4f38-878d-e747ce32417f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:3a988d4f-ac70-4a54-8246-db1cf10679ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:P18089"}
{"id":"d11b9ee1-a53b-4e6f-9ae6-d2d332fb2c1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:22068","sources":[{"id":"urn:uuid:f2dafdd6-03f0-4cac-bff2-1e039a75ca7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q61143"}
{"id":"9ca94fb8-91b3-45f0-a87a-1b5e11e6fd3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1328","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:8fd0a3de-2a19-41ee-afe4-3494785cec4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1328","original_object":"UniProtKB:P33032"}
{"id":"d3392a19-430d-40a3-8c25-dbf30257ed35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9062","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:a9212e51-a6d2-4e64-97df-7d3143791ff0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12463","original_object":"UniProtKB:P0DTD1"}
{"id":"8f288a6e-2b7a-4a8f-a508-a1b9c43a9fc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SRV0JCF9LI","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:8531d1fc-9b88-4b49-9eca-96dc1bf575a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5685","original_object":"UniProtKB:P07333"}
{"id":"683aa909-121f-4f4c-ae16-55f8045cacee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52938379","predicate":"biolink:affects","object":"NCBIGene:5151","sources":[{"id":"urn:uuid:82d0ef62-6da6-407a-a3b2-ea7740f89cc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9659","original_object":"UniProtKB:O60658"}
{"id":"88a6bace-b1cd-4db5-b5d3-4f1b1a7da5d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24820144","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:44355790-6442-4a2e-8f86-0a16e39155d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:158","original_object":"UniProtKB:P14842"}
{"id":"e3387838-9352-4ec7-87e3-3cd7e72c571c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FOF5155FMZ","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:7f5b7327-357e-4bdb-9e52-d5e2a3ac764b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9563","original_object":"UniProtKB:P42336"}
{"id":"100af120-d7eb-4317-9601-b8898775502e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:219770","sources":[{"id":"urn:uuid:71698e9c-0491-4900-b17e-717890baccbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q96KN9"}
{"id":"a6ec7e6a-b65e-4488-81e8-807f5631a3f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:2241","sources":[{"id":"urn:uuid:f3e3682d-9e8a-4b0e-8983-de5bee1bbd98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:P16591"}
{"id":"d9cf9593-2f5f-468f-8844-d8d07ad86f5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28487","predicate":"biolink:affects","object":"NCBIGene:6570","sources":[{"id":"urn:uuid:51c2b99a-2101-4aa6-bd37-93479bd38821","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4823","original_object":"UniProtKB:P54219"}
{"id":"afdbff9b-9bc4-4e8c-98d0-80499685dcd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827351","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:06e9a777-9413-4db6-93b5-821da090f037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6263","original_object":"UniProtKB:P25090"}
{"id":"c5bac356-0ec1-4654-8a97-63009f9b0360","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6102","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:5c1fbc9a-8f03-4068-b3a3-fad27746d288","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6102","original_object":"UniProtKB:P47211"}
{"id":"ab648194-1417-40cc-bf53-77e66db02f84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135574","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:2e7a3051-e8c9-4b68-9323-04c9065ca062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9071","original_object":"UniProtKB:P21554"}
{"id":"fb195421-7b46-46bb-a1e9-3308321211ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:2b05579c-7ff8-4994-a365-b1c5f1cc4691","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:710","original_object":"UniProtKB:Q8TD43"}
{"id":"5f889011-fa58-4113-a167-f8e81fd28535","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:ba74d735-7536-4334-a123-ef2f26617364","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:Q9Y2T6"}
{"id":"3810dbc9-77f1-4080-bfb9-c4d63f3a795d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3964","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:fda3909a-14d6-43ed-84f8-b5463a5b1390","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3964","original_object":"UniProtKB:Q9GZZ6"}
{"id":"d8cdd920-e3be-4ca1-bba7-a8cc35df5f6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92814","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:dceb0143-8f60-4d02-bc06-3d6a5994b15a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3283","original_object":"UniProtKB:P29275"}
{"id":"07690b55-e0ac-4b07-a7b8-c44553c1a3e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889841","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:b8d189ca-789d-4e2e-8ba4-ef1201434556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2690","original_object":"UniProtKB:P37231"}
{"id":"0d050467-cb94-4649-9697-56abee6af986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:3750","sources":[{"id":"urn:uuid:2f1a9c11-98bd-47e0-b223-c23bd14c75e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q9NSA2"}
{"id":"0065b09d-62a0-434f-a46a-eb101de23844","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:de101213-13c5-45d0-b782-eb9ec0c172d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P25100"}
{"id":"1a27c869-41bb-4508-a37b-abbf22028375","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6PJC3KPK6S","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:e0b9790f-5b8d-475d-adf9-0e0d4f6c8b27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9025","original_object":"UniProtKB:Q9NYK1"}
{"id":"c6a69b68-1514-4b3f-a630-916a7de0fbb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139350422","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:d7be0555-ad3d-44ac-89b7-51e550bae8b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12093","original_object":"UniProtKB:Q12866"}
{"id":"0402f675-9332-4a41-bd43-bd3c58fef828","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:752DF9PPPI","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:c528e996-077f-4556-92a7-dead464e9e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12242","original_object":"UniProtKB:O00763"}
{"id":"cc09d8e0-73d7-45bb-b41c-43c6e25fe4eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63115","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:fd9b0c68-7952-466f-9eac-4668d80a4744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2407","original_object":"UniProtKB:P21453"}
{"id":"03635974-0e63-4720-b053-14db0854e8ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:d001c94f-f431-40d6-af62-17d4c33c0730","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P18089"}
{"id":"c4ba8b30-1916-4939-bec1-b6049d6ed904","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95083","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:e922fe0c-385e-4588-807a-a1025ae431cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7518","original_object":"UniProtKB:O60885"}
{"id":"5aa6e43f-cfc4-4c94-b186-f11a7d48c69c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122513214","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:cf7d89fb-310f-4d09-b265-f81a76a0995b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10076","original_object":"UniProtKB:Q06187"}
{"id":"b8c4ef8c-fa86-47e6-a9a6-565e59263a34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177440","predicate":"biolink:affects","object":"NCBIGene:54822","sources":[{"id":"urn:uuid:ee242eb3-e804-48b3-bb1e-7cd789f86d93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1640","original_object":"UniProtKB:Q96QT4"}
{"id":"bd54ccfe-9c67-4543-a5b4-5eab0ebd4b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CCP2U6LWTP","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:cfcc362d-a486-4cd7-bab8-4eb8bae1dea4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9135","original_object":"UniProtKB:P48546"}
{"id":"fd634cbe-3f2b-442c-81b7-eef9a0033c2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131839646","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:e9c3ada7-5239-4d42-86f8-3770f664c517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12237","original_object":"UniProtKB:P04629"}
{"id":"39acc8e9-df88-400f-bb56-95c8f57c6de7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2067","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:ad2be3fe-18a6-466c-997e-3f228d3509cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2067","original_object":"UniProtKB:P32745"}
{"id":"e53dc3e8-7d87-4348-83b6-d6aab4103639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3644637","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:50a20d56-1ffb-4e59-9208-ed8e36f64c9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:193","original_object":"UniProtKB:P28223"}
{"id":"7dc9b4dc-b0ed-4945-9cff-a57e3b3adacb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:85473309","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:0bf34929-3c25-4387-83b0-46262a5d9eb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10286","original_object":"UniProtKB:Q9UL62"}
{"id":"2430a1d1-a7f3-4771-912a-899865814df6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15JL80DG6H","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:80be2873-dec8-41fe-8bf6-648c04587182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10658","original_object":"UniProtKB:Q16832"}
{"id":"e43fd017-f4ae-4e73-8c84-a11742c56e0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:bec8da06-df8b-4170-bb2a-f4642a3f48bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P31424"}
{"id":"58b95372-a838-4bce-933a-11b2034d9452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:cba30548-7b1b-43b3-9449-eba690cee689","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P25099"}
{"id":"8eea979e-f5a3-4050-a6fd-734f67d7f727","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S3OPE9IA3Q","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:faa15bac-2c12-4bff-96a8-afbd4389ff13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9788","original_object":"UniProtKB:P22455"}
{"id":"c257445d-5f50-43c7-8745-7da29f58448b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:0836360f-1c0e-48fe-b064-495e4399e690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q17ST2"}
{"id":"ce1d7337-a163-4735-9ade-a7127a2c0bcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:6ac3c39f-f574-487b-b6a5-039a3f9e8aca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P30874"}
{"id":"43c53b88-e6aa-4b7b-8d05-4eeab0681fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93359","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:ec4b5ef4-d9f9-4dbe-aa3e-6aa5d14d872c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1255","original_object":"UniProtKB:Q9QYN8"}
{"id":"186710eb-4b9a-48d4-85bc-bd8a75df6a80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996543","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:00b27a85-d38b-4231-820a-4e96906be79e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10709","original_object":"UniProtKB:P07949"}
{"id":"bb9c93c8-214d-4b08-a4b8-d8fa9ce93dc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VKU5X213Q7","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:2c2079a3-14af-475e-b068-4e04ae312677","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7879","original_object":"UniProtKB:P35968"}
{"id":"2cf5a10e-8c5e-40de-b156-cbb2d24f8d03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95060","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:9890117f-bfb2-4e9e-8e1b-826349e4e2a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7379","original_object":"UniProtKB:P50750"}
{"id":"c7b7da6e-2569-45cc-a92c-9a1323e5651a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92694","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:facfb458-8172-4bcd-9bf0-e9673cb99706","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4025","original_object":"UniProtKB:P25021"}
{"id":"3f67ce5c-e6d9-4442-bf29-bd3047df9a0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:276ffe07-fc8c-4ce1-a2eb-41a2b2015794","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P28221"}
{"id":"fab7c4ef-82d1-429e-990a-990b79c6aab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821941","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:d138e90f-7285-4d0f-acdb-cfd0484856f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9099","original_object":"UniProtKB:P28223"}
{"id":"7ec01e57-be1a-46be-bf26-9d9101f68b9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50931","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:c7798a32-de09-41fe-bb1b-2eb8a11a6bc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11976","original_object":"UniProtKB:P35462"}
{"id":"dd72e579-024b-450a-94c4-f4193938022e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90865","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:0242d1ab-9a27-4331-b000-8378ec86e7b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8182","original_object":"UniProtKB:P08908"}
{"id":"4e1dacd0-033d-4f40-892a-da3371768e72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280676","predicate":"biolink:affects","object":"NCBIGene:107221","sources":[{"id":"urn:uuid:6a8fd253-08d3-44bb-9791-e23ef28a4213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11195","original_object":"UniProtKB:Q7TMA4"}
{"id":"e3ed2b5e-b14b-4504-bffb-7e69ddd569a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5581","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:eabacbff-b91c-4016-aa74-b8abc8cb77da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5581","original_object":"UniProtKB:P30968"}
{"id":"0918cc9e-98e5-45aa-94fe-198cfaea3e91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11641563","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:6ac74bd4-b2ca-4dbd-a0f3-4f37261fa269","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7823","original_object":"UniProtKB:P45452"}
{"id":"ed74e21f-0d4f-444a-a1f6-84042ca56a86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:9a99a671-d8ff-45f3-b079-cdc32dd3e05d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P24941"}
{"id":"844c3965-ca81-4170-9e51-fdc785b19f2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EJL329H95R","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:c703f72b-85bb-4792-9756-cbba06d1c38b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:199","original_object":"UniProtKB:P28223"}
{"id":"f8d869e5-e95f-4f86-8b88-d4bfca32253e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:08da27e9-9e4f-489b-acdb-31ea5952200e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P28221"}
{"id":"f445100b-8027-474b-9c4c-50dbdcc08615","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51003469","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:99b35b7f-2bc6-4e19-ac54-9d30164ca03f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6946","original_object":"UniProtKB:P56817"}
{"id":"79f8011e-4c0e-4e53-879d-317fdb8abe9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50212","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d68122f6-775a-4c96-aac8-1c12e167c5c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:93","original_object":"UniProtKB:P08908"}
{"id":"39aac57e-cd1b-4264-9b57-48ee24adab86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19J3781LPM","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:ea4e3042-c0f5-4e81-81e8-e4c929f54d28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8364","original_object":"UniProtKB:O60674"}
{"id":"8caae6bb-da6d-431e-9928-534ba3515767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17823","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:4f6ab397-2095-49b9-9119-c1a0bf0bd871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2779","original_object":"UniProtKB:P11473"}
{"id":"ee7f0533-6713-4deb-a670-df9a0068cd08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185785","predicate":"biolink:affects","object":"NCBIGene:12802","sources":[{"id":"urn:uuid:cc66ddb8-722c-4a8a-8244-c5db29c8f6f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9705","original_object":"UniProtKB:P47936"}
{"id":"27d3c5b3-956e-4e04-bdc1-3c356d93f389","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10038543","predicate":"biolink:affects","object":"NCBIGene:1511","sources":[{"id":"urn:uuid:682f0bc6-67f6-4a6b-a226-cee8ae417c81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6542","original_object":"UniProtKB:P08311"}
{"id":"6fedc984-1de8-4439-aec4-d43310fbace5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:11VWK61J69","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:ffa845c9-f3bc-4356-87f1-32e60c8380c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13254","original_object":"UniProtKB:O14684"}
{"id":"98d22f6b-f365-44e3-b7af-b166f6ec0f55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996512","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:c2d3ea49-2cfa-42cb-9675-9c8e95e584aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10569","original_object":"UniProtKB:P32247"}
{"id":"475033d1-fbfb-47a2-925c-3862dc5338ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15217432","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:e27826a9-843c-4648-88a8-c7deb81eaa28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2708","original_object":"UniProtKB:P37231"}
{"id":"99b184e3-2096-4834-b525-9e91a9aae795","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91747","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:a9c75b45-7c14-4939-90fa-1f4ca58807ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:944","original_object":"UniProtKB:P21728"}
{"id":"e22f6d8d-7b9c-4be7-aad2-ff57b8cdc74e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135407952","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:9b2a239c-bc26-42b5-a8b5-d73a54509a3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5530","original_object":"UniProtKB:Q96LB1"}
{"id":"afd978c4-97bc-4504-9524-cc0703439a74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63584","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:11114883-c380-437a-bd80-934a69367213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6798","original_object":"UniProtKB:P07437"}
{"id":"c0b1d068-b2a3-4bec-bdc1-112e32a8b5f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:47e390f9-1495-45b7-b3ac-b4ac720b9d83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P12931"}
{"id":"0a0e3f70-fe19-4b08-ad8f-1d918c8de6ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4374","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:57640a84-c96f-490f-904f-485ae85b4847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4374","original_object":"UniProtKB:Q9NSD7"}
{"id":"e3e6d6b3-3459-486a-b427-9af6dd53b34d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16181638","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:1d91355e-eef6-4e6e-bd39-60cdee4458eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4161","original_object":"UniProtKB:Q13224"}
{"id":"1fe24eab-b113-4a1b-99bd-78a4d54b5761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90279478","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:16f3e2e5-0537-4b7a-9eb2-ff308d2e5220","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13070","original_object":"UniProtKB:P10415"}
{"id":"605de39e-5b0f-452a-bf22-6732aeba9d16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:304cff33-1f75-42a5-87bc-a0691b9681e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P30966"}
{"id":"f5981509-8aef-44e4-88a5-dd19c85e93ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:b44ac5cf-50e9-42af-8de1-8bcdba5ec61b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P10980"}
{"id":"3170d1cf-5c15-4180-9f15-e276c8de7f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8426","predicate":"biolink:affects","object":"NCBIGene:53919","sources":[{"id":"urn:uuid:f5847dbe-6ba2-435b-84b9-7a3a481625bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4357","original_object":"UniProtKB:Q9NYB5"}
{"id":"b9771045-ec8e-4644-979e-34c1f17b12bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2042","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:febb8589-bc21-4acc-aa2d-c5013bf6ff23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2042","original_object":"UniProtKB:P32745"}
{"id":"8edbd798-619c-4c65-86b9-a33844cacc1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49864204","predicate":"biolink:affects","object":"NCBIGene:84148","sources":[{"id":"urn:uuid:7176bc74-77d9-414d-9c3d-bc5645c70ce0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7488","original_object":"UniProtKB:Q9H7Z6"}
{"id":"08ff140e-1e69-4a65-8f45-6f31dd4eb9d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135197617","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:a1b60e9d-13ba-4918-b4f4-bfd24c6058f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10441","original_object":"UniProtKB:P42336"}
{"id":"20a1cca2-eb19-4f33-a11d-4e7b660d7bb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59234231","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:8b7fe952-149d-4a0b-90e5-bd5ed97a9d24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6330","original_object":"UniProtKB:Q14416"}
{"id":"5f5485b2-d6be-43eb-a261-1dd8c9f46a35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6541","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:6717d83a-76ff-4bdf-9c6c-60a1a9f6b1f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:590","original_object":"UniProtKB:P30556"}
{"id":"0e9c5135-e4a4-462c-9681-9214cd0b47f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9871730","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:1da1b461-bda2-4ffa-bc38-461bacfee3ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3200","original_object":"UniProtKB:O95749"}
{"id":"d9f9dbc0-8992-4c4d-897d-1e7e2fd57f2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68649","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:a2ed63ef-4706-4017-8b17-b627926ef2b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2169","original_object":"UniProtKB:P30560"}
{"id":"dc576949-d6a2-4847-8107-faf25ae2ba30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:4ef315e5-5be9-4729-a93e-4ac58015bb78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:P35968"}
{"id":"65cc7f86-0686-422a-aef5-9261789677ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93015","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:9b64c475-ff8d-4530-90dc-5285bc4137c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3274","original_object":"UniProtKB:P08912"}
{"id":"452f3cc2-0aec-4b0c-b580-5e94606d7ffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229526","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:cff2205f-2ff1-47e2-b098-f03c272aab5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8448","original_object":"UniProtKB:P30556"}
{"id":"5b5d84bd-6d92-4d7f-bb6f-5a88d568453f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F2CB8801I3","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:4c485f07-45c7-4b70-ada6-9dc8b5746cfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12782","original_object":"UniProtKB:P35968"}
{"id":"9af2f05f-72ec-4bdd-9687-ea4e6f3a2319","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NJL503AIJA","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:274cb9ea-ca49-4eea-8057-78582c717fc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11311","original_object":"UniProtKB:P21453"}
{"id":"579d322b-bc3f-47ac-b0be-55710b4af4d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:4bbdeaf5-8b7e-4e55-8077-54520ef9594c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:Q9UQD0"}
{"id":"dfab297e-7b61-47d4-ade3-3221576fd9a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5AP1ZW859M","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:2d92a07c-77da-4f85-ac91-90c7b3dd94e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9001","original_object":"UniProtKB:P97612"}
{"id":"56b0013e-ba6c-49b7-b5e8-38990bce0899","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4056","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:03e992d1-a4d9-4294-b954-aefbc0a5e59b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4056","original_object":"UniProtKB:Q96LB1"}
{"id":"89646000-e65e-4f37-bfbd-638d2aeb4c41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:a9825842-42d8-4f89-b4ff-8b6e1a9acd6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2182","original_object":"UniProtKB:Q00788"}
{"id":"91ba2c23-07a6-43ac-a5fe-c3014c9cd528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:56R994WX4L","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:57cbc65c-1148-4d60-8c2d-43a1033a6ddd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7839","original_object":"UniProtKB:P23458"}
{"id":"6ce437ca-8b4b-4fd0-88f2-9837accf79f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15657195","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:1d9afda0-8d3c-45d5-aee2-262e7c203de0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1208","original_object":"UniProtKB:P35367"}
{"id":"c21113ca-dd2d-4cf7-994f-0451e5651316","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167654","predicate":"biolink:affects","object":"NCBIGene:170926","sources":[{"id":"urn:uuid:ec80739c-3fcd-4ef7-abb3-b542bd2490f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3381","original_object":"UniProtKB:Q924T9"}
{"id":"e42816e7-41db-4a23-8635-1bdfc83919ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847605","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:094a046c-bdf2-4db5-a48a-e1f91f2961d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5771","original_object":"UniProtKB:P21452"}
{"id":"ae6dd817-e1f9-4f57-99a7-7459094e24ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81390","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:675af407-75e5-449f-b440-3d9653036d5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1251","original_object":"UniProtKB:Q9H3N8"}
{"id":"dda3bf23-7131-4a92-8d14-3c942bb3cc38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:93997081-92d0-4bd0-bc98-732c0145db4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:P06239"}
{"id":"9e55be9d-b081-4f79-ba6c-8e587eb305dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:156296","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:b7cc286f-2cb7-4443-9f49-6483374cf8d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1014","original_object":"UniProtKB:Q99527"}
{"id":"ef5345f6-d485-4057-b48f-3c997326e9c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:304827","sources":[{"id":"urn:uuid:cb050a20-d124-4e2a-9a2b-67491113b7bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q6UVM4"}
{"id":"6e3399a6-f412-4e30-8b64-4ee86fce803c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9828275","predicate":"biolink:affects","object":"NCBIGene:1215","sources":[{"id":"urn:uuid:96c63640-90a5-440e-8325-04760411002e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9779","original_object":"UniProtKB:P23946"}
{"id":"6140f804-23c2-4c52-a35e-a88edf22017b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:ccaceb36-6631-4d26-b7cb-a7b9af18c941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P28221"}
{"id":"dbf5554f-4f02-484f-9aef-1ccd88abedce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36511","predicate":"biolink:affects","object":"NCBIGene:1187","sources":[{"id":"urn:uuid:51fda77f-d47a-4c7e-a16f-bd653adc3d53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4177","original_object":"UniProtKB:P51800"}
{"id":"d324c1aa-deba-4d4c-a120-da19ffd8dfdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:a87659a9-ea5d-4f1c-a51f-7f0a7dfbb29c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P08908"}
{"id":"c6a1eb7e-4a6f-4e10-8929-7cff93907139","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:81c6d497-a741-40d5-8f27-569371e98128","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:Q9EPK8"}
{"id":"85f5d7d2-86d6-4444-b1c9-3b9600cca859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:84694","sources":[{"id":"urn:uuid:7ece475f-aba4-4839-8032-9cd5d2771fb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q969M2"}
{"id":"2c6a5576-30de-40bf-9e97-3009e0782345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44589122","predicate":"biolink:affects","object":"NCBIGene:66082","sources":[{"id":"urn:uuid:77b77653-a545-4af0-8e58-b743f32767ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11815","original_object":"UniProtKB:Q8R2Y0"}
{"id":"987d0906-92a0-4e21-9702-99d734af5f91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a1b632d4-05da-413e-a5a8-96b10d6a44f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P14416"}
{"id":"e406e5d1-100b-47b7-98bd-aa91195fcfbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90421763","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:a370c1d3-db63-44db-a0de-69174be771e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9143","original_object":"UniProtKB:Q13822"}
{"id":"f4cd3db4-e95c-4281-912c-109d1edfea83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1288","predicate":"biolink:affects","object":"NCBIGene:78976","sources":[{"id":"urn:uuid:20f34217-12c3-443c-af03-0673a322de79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1288","original_object":"UniProtKB:Q924U1"}
{"id":"f71bedf3-7ca7-4e53-acaa-611037e8ebf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:9312","sources":[{"id":"urn:uuid:75e1bd88-edef-4698-8858-8f42e26e398f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q92953"}
{"id":"d3f5851f-f3ff-486f-80d7-d5440b6180b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67WJC4Y2QY","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:2a19d91a-b440-420f-a1a1-b05ab6faa1e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:163","original_object":"UniProtKB:P14842"}
{"id":"0fc3181b-297f-4d6c-9aad-2fb63416a2ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189653","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:84523353-c778-43d7-8034-a2b85954ed0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9120","original_object":"UniProtKB:O60885"}
{"id":"234fa10b-4dd0-4634-98a0-36ea899bb2eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9TG5O4V25H","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:a106b21e-adde-4663-8e24-41b90f2f0aa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9790","original_object":"UniProtKB:P11309"}
{"id":"8e4822f3-077e-4ebd-b4e6-58fa1a16c0fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FD2SWT2SDI","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:b71891e9-2048-465a-89f4-daed04cd2820","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6045","original_object":"UniProtKB:P50750"}
{"id":"1ea55675-eb17-49e7-8531-716b7c2158d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177398","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:16ae9f68-6748-4f6b-b02b-3e155ac39dae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5605","original_object":"UniProtKB:P25099"}
{"id":"0858d559-0acc-4551-8bae-405506875510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58141","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:81d303b1-7cc0-45ec-8d2b-b893aa021b0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1732","original_object":"UniProtKB:Q9H244"}
{"id":"8c8de3ce-0725-4f13-80e9-ea8457096627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167600","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:9ffc958b-b94f-4c33-9dfc-138134b568ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9619","original_object":"UniProtKB:O60674"}
{"id":"1e0ed125-1f45-4829-9079-34f5ea7797ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YO3W29IM33","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:9fdd2184-b336-485f-8b0d-b971475d272c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11728","original_object":"UniProtKB:Q96RI1"}
{"id":"b86a215e-3123-4b1a-b601-ee50345fd85c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114785","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:6548fc41-b722-4965-a288-c1aa59c47bb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4920","original_object":"UniProtKB:P00533"}
{"id":"ad36b7c7-f54d-40e5-810a-ed4549bbcac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71506845","predicate":"biolink:affects","object":"NCBIGene:6446","sources":[{"id":"urn:uuid:c21dbf05-4001-48b0-9a71-04f0888fc73c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9423","original_object":"UniProtKB:O00141"}
{"id":"2ab1b123-6e64-4f3d-bc52-9d1cabace0be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2025","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:1d695aba-c88b-4cc7-9b4b-d7c1d08bb3c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2025","original_object":"UniProtKB:P30872"}
{"id":"433a1ff3-ec58-421d-8aaf-5adcba575601","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53466122","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:d8627651-a27e-4a2f-a605-bb758a3cd7e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12943","original_object":"UniProtKB:Q6V1X1"}
{"id":"4895c991-f2c3-4977-98e3-bf3fd138c42f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85078","predicate":"biolink:affects","object":"NCBIGene:10089","sources":[{"id":"urn:uuid:e8614c97-d538-4ada-bba2-69957ff7ffee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4594","original_object":"UniProtKB:Q9Y2U2"}
{"id":"97e3d285-0ecd-4ca5-a346-733f15b8be3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8978","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:2a6edc00-cd7c-44c0-8b03-f5c86dd73f49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:191","original_object":"UniProtKB:P28223"}
{"id":"d5982269-89ab-4210-86db-7ac8094126fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:38acb8fa-f45a-4eaa-a3e7-0115b61cf0f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P50406"}
{"id":"4ae5bcb2-b17d-43bf-b01c-b7f7190da2d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311041","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:6a7d0dd3-26e0-485f-a9c9-54d75fb36212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:450","original_object":"UniProtKB:P29275"}
{"id":"a507fe67-a2fb-4bcf-8d45-e9d2c0429935","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:de33db80-83d7-4a1b-b4d1-e495c4674d2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:Q16445"}
{"id":"a82ec720-7459-4e5a-a305-0beb6dccfec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5KM4QA7RZC","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:8dc49843-c080-4905-8b97-bfd81df6029e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2102","original_object":"UniProtKB:P25103"}
{"id":"fe37e47e-dad8-45b7-a29f-dd8002ea29f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91383","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:11e0c503-48c6-46d1-90dd-111a64bf2c09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5966","original_object":"UniProtKB:P28482"}
{"id":"82c1bdef-0af4-4388-b3e6-2c14a1d03624","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71957","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:505ab69a-f80f-4a54-800b-5c716d2ce5b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7963","original_object":"UniProtKB:P42336"}
{"id":"720bb109-dee8-4763-903c-8fc019ee295f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:6554","sources":[{"id":"urn:uuid:98e9a069-9a51-4aa8-ba65-ba91b73e6e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:Q14973"}
{"id":"c997ba04-0f3b-4d98-845f-21fb3b29b7bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11510716","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:f0dbb1dc-844e-4856-8b4c-ed8c7d96171d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11399","original_object":"UniProtKB:Q13526"}
{"id":"1904e1a4-6c98-4feb-8f23-76d2c360d1c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996523","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:33c75c9b-24a0-42e7-a4a9-9c2dcbbe86df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10587","original_object":"UniProtKB:Q92633"}
{"id":"31b38a1a-33b3-4f5d-8c26-8d6b5a8b133f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49869062","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:e85f8622-81f4-4344-8b7f-1b723cc111fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9493","original_object":"UniProtKB:Q99500"}
{"id":"d1d33e9e-4ca3-4bfb-b5b2-8e1c7eab7811","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155908701","predicate":"biolink:affects","object":"NCBIGene:8573","sources":[{"id":"urn:uuid:3ab4fed0-98a3-4a73-81e5-6d543448ed8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12810","original_object":"UniProtKB:O14936"}
{"id":"b8f17663-0d91-4e59-8bb2-7006e135e580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122705990","predicate":"biolink:affects","object":"NCBIGene:23774","sources":[{"id":"urn:uuid:34e70f85-8c62-48f9-ab5b-7790670bba0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9524","original_object":"UniProtKB:O95696"}
{"id":"9dbb4b2b-3582-43c5-ac57-e4d531da73a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H2MZ648C31","predicate":"biolink:affects","object":"NCBIGene:7099","sources":[{"id":"urn:uuid:33df52c7-f19a-4164-8781-c56d3eee71a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9036","original_object":"UniProtKB:O00206"}
{"id":"a5579113-1373-4790-a5e2-b623179c2a58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6436002","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:c7486383-69ab-4803-bbb4-c038e2eb878c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3036","original_object":"UniProtKB:P51639"}
{"id":"6f30057c-f102-48cb-a7cf-a732fcd648a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91450","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:b138f3e0-b366-4416-a93a-73282956260b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7933","original_object":"UniProtKB:O00329"}
{"id":"589e6547-ea5f-4e69-83ff-d56b86cb0b8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:a980b273-e2ef-48b4-b36a-3478819531eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P28223"}
{"id":"5e3bda43-57a3-4cde-8d8a-dc76ea06e5f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:a93689fc-9125-49ca-bb5a-14ac5f022568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P35968"}
{"id":"2e59c20b-1ae6-477b-a275-e0203512d3b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:21d1d753-8d95-484d-bd68-b38b7abb4839","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q9BY41"}
{"id":"4687f29e-0fff-437a-acd6-c62cdbe9f4d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9822RX831L","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:597dd216-99d6-40df-b811-982279ce656d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4000","original_object":"UniProtKB:P32297"}
{"id":"830ec87d-e19d-4292-8e48-48ca68b52b78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129665","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:5e93e756-ed19-45e1-8b5f-2784c530c0b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1155","original_object":"UniProtKB:P41587"}
{"id":"141659bc-7880-4fd2-8e27-4cba72d0b9f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817418","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:5c41694a-220b-4ef2-999c-3bee5f1bfad2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1510","original_object":"UniProtKB:P49146"}
{"id":"451912cb-b6b5-4d62-872a-785c1a093cd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114187","predicate":"biolink:affects","object":"NCBIGene:24613","sources":[{"id":"urn:uuid:7034a140-e4b8-4cf9-bb7a-5602a9f51495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9002","original_object":"UniProtKB:P33533"}
{"id":"177c3882-ac3c-4fb0-9768-0f532e536efb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310983","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:2cacabc0-5b7a-48e3-9578-71b05ad1f51c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1711","original_object":"UniProtKB:P47900"}
{"id":"9cabc483-ea05-4af3-8e6f-48ec3bf1a00a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:a09cc961-78d2-4dcd-b695-f1896aa9ab97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:P34972"}
{"id":"76527023-96e7-41f9-aa24-4b7dee35e3db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2190","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:d3905d3e-e559-447e-87d7-aec8351e9a84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2190","original_object":"UniProtKB:P37288"}
{"id":"50eea818-b00c-4281-9096-4524d1007a2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755190","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:d64e5178-beaf-4727-8ffc-bb39f8e1fc9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6216","original_object":"UniProtKB:P31424"}
{"id":"79017018-1d42-47fd-8a42-d0adfed29ead","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137064","predicate":"biolink:affects","object":"NCBIGene:91","sources":[{"id":"urn:uuid:ad5c5ae5-1b17-4dff-be16-499787e01c8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7797","original_object":"UniProtKB:P36896"}
{"id":"3eefb046-cf23-4fcf-a010-a23df908b19a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:16a3ad2c-4c94-4612-a86c-d1ac7a7d1cbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P45452"}
{"id":"c358063d-67a8-4e0a-b1d1-3326b9917850","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8093","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:782998f5-4e44-4a8a-a00c-c60c25a839ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:485","original_object":"UniProtKB:P35348"}
{"id":"92aa7dc0-6fd0-4065-8061-251701232002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8426","predicate":"biolink:affects","object":"NCBIGene:9356","sources":[{"id":"urn:uuid:5c63a8ac-500a-4bcd-9c3b-c58e9211f138","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4357","original_object":"UniProtKB:Q4U2R8"}
{"id":"92b16899-95ca-42c9-beb1-6963deb943af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2709","sources":[{"id":"urn:uuid:8381e23b-9bb9-4b07-9697-0c1e0b0e2822","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:O95377"}
{"id":"d40e0136-2486-4da7-8d8c-915c73c88915","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317097","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:14597628-ae3c-4043-8d7a-36905bfab4e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7724","original_object":"UniProtKB:O95180"}
{"id":"acb0c037-8a5e-465e-97fc-727f249e2f82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:64386","sources":[{"id":"urn:uuid:d1c7e17f-9615-4967-bafa-b5b7c6d84b03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:Q9NPA2"}
{"id":"22afccdf-8a98-45b0-bbc9-8acc6b4ad0be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:40237fe5-9f64-4491-8572-a124a568a14a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q9Y572"}
{"id":"b0f8dfef-5131-4c4f-b7f4-c2d5ec5e811a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13890","predicate":"biolink:affects","object":"NCBIGene:1493","sources":[{"id":"urn:uuid:83c3d34c-c202-49a0-ab4e-0308f75c2c31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13890","original_object":"UniProtKB:P16410"}
{"id":"dd251eba-64de-49f4-9703-cad5916aea7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817385","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:7c78225d-5f69-47a6-b7ea-412ed8d8cb2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:923","original_object":"UniProtKB:P47866"}
{"id":"82f68a59-46b7-496f-8ea1-7c78b468a15d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90217","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:6f8ac22c-3371-499f-ae9e-aee70048a70f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5658","original_object":"UniProtKB:P36888"}
{"id":"44aa31b7-423a-4332-bb5c-72d7aaef6847","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135652","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:4b55232c-080a-4ac3-b217-65a60c60591a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12488","original_object":"UniProtKB:O43497"}
{"id":"456098d0-1e72-40db-b58b-ac1f36849998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91734","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:ee2cf990-2d24-4a7b-bfb6-9c85aa76115e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4705","original_object":"UniProtKB:P30531"}
{"id":"35e7bbd1-d902-408e-b55f-3d73afc5e580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80229","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:6c5d523d-4028-4288-af28-9dfe11d8821e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:616","original_object":"UniProtKB:P52500"}
{"id":"42fa6748-8ecb-4314-8d7e-a81c8042e197","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817474","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:0679cb7d-1364-4acf-9c7a-d5c06c4efe8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5357","original_object":"UniProtKB:O60755"}
{"id":"2dba19d3-cba5-46bf-b671-c1ac4d1bf794","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:22034c33-faa9-4d5c-83f9-01c8b3c5d24d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1641","original_object":"UniProtKB:P41143"}
{"id":"f43e3dd1-23d9-4eaf-a3ee-42b94b9f7686","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3B2GI648A","predicate":"biolink:affects","object":"NCBIGene:942","sources":[{"id":"urn:uuid:e683e604-dcfe-4e0b-9359-71840c8fdc2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6892","original_object":"UniProtKB:P42081"}
{"id":"bc4f6c84-e187-4475-a4fc-b9835532b4d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6420160","predicate":"biolink:affects","object":"NCBIGene:2899","sources":[{"id":"urn:uuid:ff3a70eb-411f-456b-a308-3994a813e71d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4092","original_object":"UniProtKB:Q13003"}
{"id":"b3244ac6-7586-4e67-ad79-5386ec686edd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:e5ab04c0-2eae-42d7-a15f-b6611f4c9838","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P28221"}
{"id":"9d5067e1-da4f-40ef-9293-3c6f0fd2eef1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:e00d92cf-5514-41ea-addb-062efdb53e86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:P48167"}
{"id":"3cc2a05e-ff64-4c65-9c76-8509815a9df5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KT54N4CC67","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:3eb96c07-a15c-4e82-8a40-01be71e271c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:160","original_object":"UniProtKB:P28223"}
{"id":"33f0f057-e5e1-4725-a7a0-88d6d80d4183","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4545574","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:fbdc0526-a6f8-4abf-969d-bc1d59c0a8d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1406","original_object":"UniProtKB:Q14831"}
{"id":"f4b92a5d-555f-4f05-8611-a2f4ef14f159","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71509622","predicate":"biolink:affects","object":"NCBIGene:6546","sources":[{"id":"urn:uuid:42f0b2cb-4e92-4ed0-a02e-3e902c38fc95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13934","original_object":"UniProtKB:P32418"}
{"id":"a632710e-2c81-42eb-982a-530c13d6d768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817515","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:c699adb9-5249-4add-b33d-45ace074d445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11408","original_object":"UniProtKB:P0DTC1"}
{"id":"03ac1fb7-2502-4ea2-a891-cbdf2c6c7a63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155411202","predicate":"biolink:affects","object":"NCBIGene:11143","sources":[{"id":"urn:uuid:916afbeb-05fb-4b5e-b2a3-033fc184b2d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12938","original_object":"UniProtKB:O95251"}
{"id":"a5e43c8d-78aa-4d8f-add5-6e8c6055a5de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UMD7G2653W","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:ab53b231-2975-4438-8f73-5f09500fc4ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3059","original_object":"UniProtKB:P14324"}
{"id":"f36f4a59-6c97-4862-a396-ed0f772408fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:29718","sources":[{"id":"urn:uuid:0aa7602c-895b-4e63-bb7e-d12c6896e698","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P49655"}
{"id":"7800d454-73c4-4641-b4bb-de57f4599857","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10062394","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:14bb65db-2a75-4c04-a4e9-3ada33479c8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:304","original_object":"UniProtKB:P08172"}
{"id":"f8c72fda-7edb-4ce9-b2f0-5a90cc3e300c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24771260","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:705e8563-17ac-408e-8003-d7a2f33b9848","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6987","original_object":"UniProtKB:Q92633"}
{"id":"52d4f090-b7ab-41d8-a714-618fb623c28f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63453","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:4ba252c6-4524-4ff1-882a-7d1888130e94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7707","original_object":"UniProtKB:P22607"}
{"id":"1d9c3666-4758-4702-9bf9-77632d179d30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6163","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:b659ece2-3046-4414-8315-dacb6516ddf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6163","original_object":"UniProtKB:P30550"}
{"id":"6a776015-db64-48eb-bb62-240901a8cd60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34637","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:7a93935f-9a88-4077-9fbe-a94c459810ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2589","original_object":"UniProtKB:P51787"}
{"id":"07fb4ffd-a728-4ce9-bc51-625ed02ebb89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48273","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:a6496b9a-2f20-4e78-8c72-3bd5036a1666","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:51","original_object":"UniProtKB:P28221"}
{"id":"12d015f8-d305-4303-8583-9c591b33ad9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190326","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:d97f70e6-c2bd-4998-9b18-d968f71b498f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:731","original_object":"UniProtKB:Q9Y2T6"}
{"id":"f6e79e63-c2df-4b81-9dda-395f08654cfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5461879","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:2c5b9b21-cf0d-4c59-9e18-b1e3f1e05066","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5603","original_object":"UniProtKB:P29274"}
{"id":"378813ae-04d9-4cf5-8876-39a6dc1fc15d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64055","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:9003b798-e077-4ca4-abec-3de692d7c9ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:109","original_object":"UniProtKB:P41595"}
{"id":"a78076f2-348b-4dfc-880d-57099ada0d8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11545","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:253c9792-9c14-449a-8db3-4c14872bc3b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11545","original_object":"UniProtKB:P22455"}
{"id":"280d02ee-5a0c-473a-8fe0-32dc242e068a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68181876","predicate":"biolink:affects","object":"NCBIGene:10298","sources":[{"id":"urn:uuid:bf3a45af-348c-4bde-9b47-344c2c860901","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8941","original_object":"UniProtKB:O96013"}
{"id":"404826b0-1aef-4ab7-a3db-fa0cf3389f02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94644","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:2b5b30da-29ca-4551-90ce-3191f421bd23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8068","original_object":"UniProtKB:P06239"}
{"id":"006d54be-36e0-4271-bbb3-21d42c10254f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95061","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:4f891e15-17cc-4736-8900-56e485966f00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8784","original_object":"UniProtKB:Q86V86"}
{"id":"412c2d93-a67f-4441-8ab0-e26bdb4f04a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:8645","sources":[{"id":"urn:uuid:d2cd7ce0-260d-445e-bfc6-f3e68bd25d58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:O95279"}
{"id":"db5349be-ba93-4175-8003-e00887f41cad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44331923","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:e76c9ade-21cb-4cc0-ba7b-984f0509f5cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2970","original_object":"UniProtKB:P04035"}
{"id":"1d0ab227-90fd-4744-a945-44ef73868a9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6360","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:d7d8f4f5-5522-4852-94b0-d69a00cd5847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12499","original_object":"UniProtKB:P59537"}
{"id":"42d24003-0e14-49ff-bfac-48a8cd48be8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:7280680e-0711-46f6-a285-584f6cc66d26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P41595"}
{"id":"31595065-007a-41a1-b821-1c9b2e880f08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118705601","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:9c21fa3c-00ac-4aee-ab46-d8e7391714ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1520","original_object":"UniProtKB:P50391"}
{"id":"2ea6c234-4b4d-4627-8733-b7aaeef051b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:228cb5ab-9c35-4a28-8a17-09eb0902ef1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:P35523"}
{"id":"0af4043a-2b8e-4eb2-ab0c-525a6437382e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155749520","predicate":"biolink:affects","object":"NCBIGene:8986","sources":[{"id":"urn:uuid:be796f98-d366-4332-bf29-04dba7b8533e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12059","original_object":"UniProtKB:O75676"}
{"id":"33f2b785-d57d-4f65-b6d9-f228c0b65f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3084","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:9af6d2a8-9e61-40e7-a2ed-fb2466896d5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:297","original_object":"UniProtKB:P08173"}
{"id":"19afeb51-fc1b-483a-a45b-58b760be2634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2237","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:86a2243a-1111-487e-a5e3-832442cbcd98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2237","original_object":"UniProtKB:Q00788"}
{"id":"4f8934f3-020a-4c83-8d6a-859794fab171","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45483651","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:bda86ddc-76ca-4390-8977-7c20ecff63fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9193","original_object":"UniProtKB:P35372"}
{"id":"ac4def3b-3f26-452a-a4bd-b9f9cc2de33d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:4d28eef1-a03f-4515-ac34-9e076abe841c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P28221"}
{"id":"9eb9e144-df48-4413-b704-5c9e8986db99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44370557","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:26e6dcd5-d89c-4d10-be5b-f48400075db4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3089","original_object":"UniProtKB:Q02769"}
{"id":"5d69d169-d183-491e-82a1-574dea931187","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:75f0571f-6348-4db0-8973-b0e50541c358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:Q16445"}
{"id":"24987912-c267-4a4a-ae8b-56bcbf01d254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93509","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:160d9b0b-2566-47b1-bfa1-73142190df1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13128","original_object":"UniProtKB:P18825"}
{"id":"26975866-c871-4aec-ac9b-ee7e630db84d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135522368","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:e3574e31-0175-4b87-9fd5-9479adc86af2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:383","original_object":"UniProtKB:P30542"}
{"id":"90f3b37d-aba6-4e0d-8d1b-7da4d09a7e7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21037647","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:77b53970-011b-4614-8f91-1b64e38c713f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2473","original_object":"UniProtKB:Q8R4D5"}
{"id":"daa414a8-7118-427f-b1ae-fb96f30d85f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36791","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:d41e197e-0c73-48c4-8bc3-f9f4b33b68d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7177","original_object":"UniProtKB:P31645"}
{"id":"3d2d9c81-6b68-4776-a11e-5e4d4c68463c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6803","predicate":"biolink:affects","object":"NCBIGene:462","sources":[{"id":"urn:uuid:0043575e-6ba5-468e-989e-17f7a1dcef77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6803","original_object":"UniProtKB:P01008"}
{"id":"949796c6-d686-410e-a7db-adcba40cdd16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191023","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:ae7f7eab-4bac-4571-bcc6-1ef0533de5e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5857","original_object":"UniProtKB:P35408"}
{"id":"171b86cb-f122-415a-b124-84d1081fd7f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:773","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:78fa1a81-98d1-42e4-a261-51c4bb491943","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:773","original_object":"UniProtKB:P51677"}
{"id":"19afb523-ed5f-47d8-923c-60d57a562c72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46225540","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:072ce5ae-3f87-4ecb-ae5b-1a9a736474c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8181","original_object":"UniProtKB:P23443"}
{"id":"0ec6cd7b-1b6b-47a3-b40f-d0379a2853eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93419","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:29107c63-1a07-4c23-84f0-91b5cd43c0b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10556","original_object":"UniProtKB:P14618"}
{"id":"0a1e1ab2-60ca-4e96-8723-9761e36b89fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755206","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:535c6abe-4ac9-4fe1-a865-b7e4576735d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6325","original_object":"UniProtKB:P31421"}
{"id":"c35b9b5a-42a8-401c-8c48-a5c1387bf40e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63633","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:bf175ac6-d57e-44eb-9faa-ecc23e9d7621","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1177","original_object":"UniProtKB:P30969"}
{"id":"f0d79cd7-4ca9-4400-823c-a87f7901d76a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:29bb6ec9-3400-42cb-b707-e594333e3762","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P08588"}
{"id":"29ba2a5a-95b4-42f5-b406-a9a94693f375","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44275335","predicate":"biolink:affects","object":"NCBIGene:81681","sources":[{"id":"urn:uuid:78944562-4647-4b71-bbab-959348fc6f0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6707","original_object":"UniProtKB:P48450"}
{"id":"2fe955f8-831a-4c31-b9f6-6e691d536f8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144869","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:1c14b38e-a781-4e71-8147-56bcf97b1093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5762","original_object":"UniProtKB:P21730"}
{"id":"5ebdc674-80e9-44bc-90b6-940d82fa409d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91433","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:946003c2-992a-45a7-af11-829561f5d545","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9383","original_object":"UniProtKB:P07333"}
{"id":"49cddf6e-78c7-41a2-b64c-fe73cc7f6a78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18397","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:b8d1c6d6-f0a8-4024-993d-71de9f176379","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2144","original_object":"UniProtKB:Q923Y9"}
{"id":"2190d79d-a879-4049-abb3-710993ffaca3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:4843d1f8-cfcb-4eb3-a989-c8c7e366ca1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P28566"}
{"id":"9035ade2-4854-409e-a02c-919a4a28a1ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7571","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:a9731d10-fd1d-4203-9aac-007e8e47b152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7571","original_object":"UniProtKB:Q99250"}
{"id":"eb3df689-7d9e-46d1-9289-f02f7db3a526","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49858117","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:4ce09fed-1599-4053-af66-4019af68bb05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6223","original_object":"UniProtKB:Q14832"}
{"id":"74de9cc1-0fc0-4666-8669-b06bb2b95429","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:13962732-23ca-464b-8e7b-c2d11dbe74ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:P47211"}
{"id":"d7a3addf-8cfa-4bce-898e-1a058c947edd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:758","predicate":"biolink:affects","object":"NCBIGene:10936","sources":[{"id":"urn:uuid:c0a9baa3-4df4-48c7-8510-5d47d0763848","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:758","original_object":"UniProtKB:O95800"}
{"id":"55d5ca17-68ad-467a-8f57-430c3581898a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17688","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:0a1cdaea-436e-4c4c-b1a7-f37e69aaa874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2585","original_object":"UniProtKB:P43681"}
{"id":"bf48bbc8-7161-40f1-8b39-91dac54f3c0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:433cf978-3e8d-42de-aff8-545c0ecfe4ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P15056"}
{"id":"40c7d7e4-f986-4d32-b020-1996a87300c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1327","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:b143cb95-eb4d-48f9-8838-2a8d615bc767","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1327","original_object":"UniProtKB:Q01726"}
{"id":"3871c1d6-9e40-4d35-a4fc-8ccc04a4953e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15368","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:44aa3983-f64b-4945-a552-8c2e1f57c1d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2418","original_object":"UniProtKB:O75762"}
{"id":"15526557-5ced-41f6-b3fe-cd21310cf3d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9980734","predicate":"biolink:affects","object":"NCBIGene:3762","sources":[{"id":"urn:uuid:d9e9d8fe-de5c-4a54-9f22-694fae19bbcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2408","original_object":"UniProtKB:P48544"}
{"id":"e61dbc18-bc4a-401d-938b-39f334c89190","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71280305","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:8f770499-74e1-4927-b060-9d6297932cb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12870","original_object":"UniProtKB:P10721"}
{"id":"babe7e61-c06e-474c-931b-5eb3a30ab34f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F3YMY7783P","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:3ef34de2-d8a0-48a7-9f9e-a37dcf4cfd22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11699","original_object":"UniProtKB:P48736"}
{"id":"3c51698c-66d3-4997-aadc-7a66693f8144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:5f18d1ed-a14f-450b-8f89-dbd7fe4ecfaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:P49841"}
{"id":"b5366a32-54ab-407f-9871-dad9006fdf21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121362450","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:68b73c2a-f3f6-45a8-bd2d-3929ced782d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12154","original_object":"UniProtKB:P05164"}
{"id":"0a041638-a5b9-4b94-8974-534ac6918eae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:fa06ddea-6cc9-4a12-9241-ec2450d1873e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P34969"}
{"id":"55d41aa3-75c9-41b3-85d5-6f9a0c837438","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0CA0VSF91Y","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:5957f79a-dd66-4d2c-b6af-d1352cbdb1a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11410","original_object":"UniProtKB:P23458"}
{"id":"bf960460-a303-42b0-9e23-464849f6741f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10333202","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:96792459-62f6-4aed-a312-d9bd0e0b85c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9102","original_object":"UniProtKB:P09960"}
{"id":"460098d0-264a-42b8-9d54-4fe7e0d20784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TR7I0800L2","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:4d0d52d6-f25f-497d-bd2e-2a6b7b365860","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4328","original_object":"UniProtKB:P28476"}
{"id":"38191add-e51c-4431-b195-72573f5934b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15365","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:d5a0deca-039d-4dd1-a93c-6ea89d16f8d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4139","original_object":"UniProtKB:Q9UHC3"}
{"id":"09b985ee-7960-4634-8c97-ef96a2f521e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6107","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:f9fa28e3-3bf9-43ee-a2cd-613b4fc443c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6107","original_object":"UniProtKB:P47211"}
{"id":"04804ce3-a004-486a-8871-30db9e83d02c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JJC99KHGL","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:4bd3c2f8-3d3d-4bb2-804d-6a8be070a55d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11118","original_object":"UniProtKB:O15379"}
{"id":"954f0708-b538-433d-9454-a0db95d5e05f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10062394","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:cfdcd0a8-12e6-4483-8341-ca9fedaac574","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:304","original_object":"UniProtKB:P08173"}
{"id":"52cacd2b-735e-48f6-98d0-4ead0b77a97e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135586","predicate":"biolink:affects","object":"NCBIGene:21390","sources":[{"id":"urn:uuid:6f513ab7-1b24-49c1-913c-584c6f6254e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1979","original_object":"UniProtKB:P30987"}
{"id":"4c8e612c-1af9-4d03-9332-f310b0c880ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90724","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:39f0711f-61fa-4462-8331-1a67360f8dc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3317","original_object":"UniProtKB:Q9Y2T6"}
{"id":"cd3f901c-af30-4244-b8c0-0b5da9bbf4a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6CE2107J4T","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:8b080a41-639d-42cd-9f25-83534274c756","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11676","original_object":"UniProtKB:P04626"}
{"id":"e1e1d2ae-9c54-40d2-befb-7e61ff202c9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MZK2GP0RHK","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:72b306b4-1434-4dee-b6b7-b65df61b1481","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8309","original_object":"UniProtKB:P23458"}
{"id":"6c056bcd-75fb-4efd-af51-de8a41ad700f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2965","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:9bcf7f36-093f-4d70-95ca-4d9c89e68fcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:997","original_object":"UniProtKB:P25101"}
{"id":"2171b9e4-b1fc-4067-a591-911d23e89dd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50169","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:13579ec8-cd7b-4cd9-9ade-aef333709c89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4108","original_object":"UniProtKB:P48169"}
{"id":"bf3bf053-2015-4b1d-843c-e317e6759dbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7764","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:a3d2759a-63d6-4f30-92ba-989c16052472","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7764","original_object":"UniProtKB:P15387"}
{"id":"d15aee42-9eed-409b-9674-63c9aebd45a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:cab75a29-bdb1-4910-aff1-c32eeaea3b5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P10721"}
{"id":"7830d86b-f821-42b4-b851-4f0ef241f061","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188219","predicate":"biolink:affects","object":"NCBIGene:25302","sources":[{"id":"urn:uuid:3e95defc-0758-4f2e-b9dd-deb594be24c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11384","original_object":"UniProtKB:Q05941"}
{"id":"a09641f2-30e0-4839-9306-3d62a1c558da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131144","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:c1399b11-e931-4824-9da2-513460208930","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6623","original_object":"UniProtKB:Q9NYA1"}
{"id":"265c3995-fe04-4171-b111-a672e188a12e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3063228","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:e93b364f-6327-4616-a6b3-042b2bbc9d80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1274","original_object":"UniProtKB:Q9H3N8"}
{"id":"a3a6428c-9148-4287-978c-0995cc4adedd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311225","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:3d89d1c9-7559-44d6-9f5e-22cb856e909c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1918","original_object":"UniProtKB:P43088"}
{"id":"fb84f4d8-4042-43f7-bc20-d4f22405b813","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10078814","predicate":"biolink:affects","object":"NCBIGene:1509","sources":[{"id":"urn:uuid:789174ed-d8d8-4c80-b559-e49eab84467b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8634","original_object":"UniProtKB:P07339"}
{"id":"4a9dab96-398d-4ed5-89f2-10eb0c0382ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BSOIY5AKQW","predicate":"biolink:affects","object":"NCBIGene:84649","sources":[{"id":"urn:uuid:73b92d11-e171-4724-aa4a-1a7e0eeeeb8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12241","original_object":"UniProtKB:Q96PD7"}
{"id":"f25a7ee0-b9d4-4d6d-bbf4-d7654adaada5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91380","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:54ce2e49-09f1-492d-84de-1236c6b8fd07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11665","original_object":"UniProtKB:O14965"}
{"id":"1b5b7d68-0e32-45aa-8775-a54675e19121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91348","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:cf463ada-bc7a-43e3-a6c0-0e843a3b1d76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5706","original_object":"UniProtKB:P43405"}
{"id":"c3dc545c-38a5-4cc1-975f-0568d1d4d400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90531","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:e8057674-6345-4356-b023-3bd0c468efe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7946","original_object":"UniProtKB:P05771"}
{"id":"552ac987-a958-48c4-bc65-2f57180c7420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172333","predicate":"biolink:affects","object":"NCBIGene:8529","sources":[{"id":"urn:uuid:e205c568-f15f-4aa3-a7fa-93eff4fd6077","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11373","original_object":"UniProtKB:P78329"}
{"id":"e9d996e6-5c1b-4b7b-a2be-0aad663b5aee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:04XPW8C0FL","predicate":"biolink:affects","object":"NCBIGene:5340","sources":[{"id":"urn:uuid:9f57edda-d933-426b-956b-cbe067d5dd22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6570","original_object":"UniProtKB:P00747"}
{"id":"bc559481-235b-44ba-bf64-263bdb1af93c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1517","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:fd71e20c-29b3-4b89-85a6-7ba36adf710a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1517","original_object":"UniProtKB:Q63447"}
{"id":"3e0ef34e-d9b0-4fcb-b3fa-b7da2bb42fe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4653","predicate":"biolink:affects","object":"NCBIGene:8622","sources":[{"id":"urn:uuid:05171886-1654-4c37-ae20-2c8dfc0ad21f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4807","original_object":"UniProtKB:O95263"}
{"id":"7e74b542-edc5-4715-901c-8fba76188323","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679535","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:3aead246-7fb4-430c-9288-05ee38a296d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11844","original_object":"UniProtKB:O14744"}
{"id":"bd803309-6040-46fc-8ed0-0a7c11908d9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0896DN89BF","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:57b9d22b-0de1-4233-972c-978687216eb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6427","original_object":"UniProtKB:P41594"}
{"id":"5f436e4f-1fc8-4f82-a262-c9ef0a75dc95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:486830","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:fc01454f-f9c5-4bba-8f36-0ec7ec3bd1bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:768","original_object":"UniProtKB:P32246"}
{"id":"1eed1751-9c81-4356-98e2-a56cad2583e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z25PJ77W7V","predicate":"biolink:affects","object":"NCBIGene:210198","sources":[{"id":"urn:uuid:1c3de02a-6caa-4631-86d0-041d993951f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:716","original_object":"UniProtKB:Q8K4Z6"}
{"id":"6df12c3b-ba44-4efa-8abd-43a51f876d69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:fd5c6315-d66c-4ec5-b802-7030b13fa74e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:P06239"}
{"id":"ee5ade2d-2b03-4e87-8cc4-4c5db7d6c832","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:28Q8AG0PYL","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:9f322959-8516-48f2-a321-cc3726d80fc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12737","original_object":"UniProtKB:Q07869"}
{"id":"93b728af-8945-4060-b4c1-f961532b867b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46236221","predicate":"biolink:affects","object":"NCBIGene:4296","sources":[{"id":"urn:uuid:cb8b20bf-9254-43cd-b473-cbf8d291f7c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8195","original_object":"UniProtKB:Q16584"}
{"id":"23b9ec1a-1b57-42f9-903f-ebc8a74860cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121439991","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:8d615364-dcef-45f8-b718-cf89ceab82ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9643","original_object":"UniProtKB:Q13546"}
{"id":"e5ff331d-bfaf-419e-90f2-bc886a10eddf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817429","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:c257fe91-3c2c-4d46-a932-dc7da405be8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1814","original_object":"UniProtKB:P49190"}
{"id":"e7de2099-bac2-4393-9d03-38e3f620df53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7542","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:1a1c3bd9-67f8-4f42-8f35-8e286bdd3ac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1579","original_object":"UniProtKB:P30989"}
{"id":"a23fa648-404d-4f63-9529-273d1b1d54b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:30269a93-f3c3-4d04-a078-2788ca1080f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2491","original_object":"UniProtKB:Q8NER1"}
{"id":"1f079bb1-422d-49ae-9127-593afee6dd9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:100126572","sources":[{"id":"urn:uuid:babbd5b2-ebf3-4505-912f-929a58eb860b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:A6NN92"}
{"id":"94607f7b-6edf-44b8-bf47-18769185fcec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46196414","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:1c71a061-90a3-4065-b1df-f030608da777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8549","original_object":"UniProtKB:P11229"}
{"id":"c289b484-7e8c-446e-b3f1-8970c4ec9f9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:36295259","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:958a0143-b915-4c73-9a54-9b766be8fcba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13052","original_object":"UniProtKB:P32249"}
{"id":"649ea78a-098f-40c7-8074-b1bfc8a6c426","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59787819","predicate":"biolink:affects","object":"NCBIGene:4883","sources":[{"id":"urn:uuid:536e780b-07ad-4a5b-9c69-ce1e81693473","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5020","original_object":"UniProtKB:P17342"}
{"id":"3dd4072e-da83-4cd3-851f-e6d52d4b044e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92090","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:c0c8e9c7-cd15-49b0-995a-7a74b9902734","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:177","original_object":"UniProtKB:P14416"}
{"id":"fdc3f371-8342-43ac-a22c-0a5fcc233f35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10341876","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:b8a4c392-db89-4998-992f-fd54b89229c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9755","original_object":"UniProtKB:P21731"}
{"id":"c9b25d94-cb2f-4643-b8ac-f3cde921c1ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:29b71d22-24b0-4717-832f-90030d4c319a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P30939"}
{"id":"7d38edbe-8c72-4646-8213-0f60d9d38f48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5296","predicate":"biolink:affects","object":"NCBIGene:11309","sources":[{"id":"urn:uuid:15377991-bce8-4d58-a447-0e0d15de9ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3439","original_object":"UniProtKB:O94956"}
{"id":"8f54d9b7-f779-4826-bc86-dcdce30819d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433291","predicate":"biolink:affects","object":"NCBIGene:4929","sources":[{"id":"urn:uuid:29e19c9a-f3e6-4ace-9819-51cef78eaacf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12651","original_object":"UniProtKB:P43354"}
{"id":"84e0b782-2029-4bb2-8007-1f0bd90c73bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2857838","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:429dbd89-9f76-4ffe-9cd0-83f266b4b9d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3962","original_object":"UniProtKB:P36544"}
{"id":"9117f1b3-49db-4759-a7a5-c05801bf7b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46946406","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:662f9e4a-5c1c-48f8-ac6f-9cbd546af085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6414","original_object":"UniProtKB:P31424"}
{"id":"40326e83-d5c1-4f15-8236-5c98f644a8e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I7MVZ8HDNU","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:835de0a8-b5da-4e40-9c5e-a9be9995d35f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10457","original_object":"UniProtKB:Q06187"}
{"id":"369fab4f-b855-451a-be42-808f2d5ef3d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:8ad5a6ae-aab8-455a-93d6-010275c624ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4193","original_object":"UniProtKB:P31644"}
{"id":"25089037-df4c-46e0-b394-fc8d418b9f9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6E68796C40","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:79611d87-6c57-4d09-b95f-66fa01e13291","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5593","original_object":"UniProtKB:P29274"}
{"id":"70377e94-addb-4c33-bb0a-fc841384a34d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110176","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:494a1f09-cc66-49dd-b5af-69ebbe2c4eca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3264","original_object":"UniProtKB:P11229"}
{"id":"08610662-bdf2-4ac8-87fc-0ee9325ab46f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659967","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:359bb611-73b1-4664-a890-c7be154d3936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6345","original_object":"UniProtKB:Q13255"}
{"id":"154c8b72-8f8d-4bc4-aeb1-0e581e3a80e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13066","predicate":"biolink:affects","object":"NCBIGene:9817","sources":[{"id":"urn:uuid:35d7db42-a11e-4fa7-a590-216b0b9e1a6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13066","original_object":"UniProtKB:Q14145"}
{"id":"f37440cf-c1b9-44ce-b8f4-4e1bc95ab2e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3353","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:a3bdd787-da8e-4347-a331-c148d6fde930","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6492","original_object":"UniProtKB:P08473"}
{"id":"b4c73b69-07ed-4752-be69-b96c7be56243","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10078814","predicate":"biolink:affects","object":"NCBIGene:1510","sources":[{"id":"urn:uuid:21817a35-4697-4e32-bc10-d5b14d0844ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8634","original_object":"UniProtKB:P14091"}
{"id":"8b44dd73-02dd-459c-a78b-6d44c3d3625d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H2OL3Q4XRD","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:0fab2725-eb01-4187-a69f-a58b9d0e43e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10460","original_object":"UniProtKB:P35968"}
{"id":"5548b8c2-26b7-4a79-a4ab-91f981db5786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:e8db3fb6-8f6f-4546-9a9b-92e2203e5630","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P08908"}
{"id":"db43fab5-725b-44b4-a033-a4b76f88b6d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15508178","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:5fc18470-f26a-4602-84a3-8ff7941e9011","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1436","original_object":"UniProtKB:P35349"}
{"id":"35489c87-4291-407c-b0ee-493e2415aa10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32181","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:8c9c1e4b-ecb7-4154-8514-7d8353c176f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2648","original_object":"UniProtKB:P13631"}
{"id":"a394d0c1-46a4-40c2-af03-8206dd7205d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:3b11e1e6-915d-4b32-ba46-2b55d21dc52c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:O08858"}
{"id":"6aba8d6e-b76c-43f1-8647-bfae91edb0a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71682837","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:c8531135-c494-47b7-823c-2a855b95d627","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12119","original_object":"UniProtKB:O00329"}
{"id":"3db0c572-652c-4542-802e-da0f9f785b61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16116566","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:713e89d5-222b-4415-8260-03e0033c664b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1733","original_object":"UniProtKB:P41231"}
{"id":"b31c3bd2-3301-4b1f-a808-5388f89fc3b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44331788","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:39f96cae-9218-4ca9-ba09-3afe616f940e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2979","original_object":"UniProtKB:P51639"}
{"id":"9e41678f-b9b1-41a6-a1a5-8c2820623583","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6775","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:58caa1b4-7d8d-45ab-ad38-506ecb44c222","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2700","original_object":"UniProtKB:P37231"}
{"id":"400391fc-4541-46c0-a9ba-2d25c38ec2a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UYB6UOF69L","predicate":"biolink:affects","object":"NCBIGene:6555","sources":[{"id":"urn:uuid:f2b66aa7-fc56-41fb-820f-d60ff3c56c05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11708","original_object":"UniProtKB:Q12908"}
{"id":"7427671a-4b7a-41c4-9cb1-c9d1d0e2c93c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23056","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:0129b084-eaf7-4fad-94ad-ab8fd933e03e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:318","original_object":"UniProtKB:P08172"}
{"id":"69245196-49ae-4fb0-92fc-962215ea434c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:afd62b8e-841e-445e-ba2f-4656f2805f5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P21728"}
{"id":"b502e427-a7c7-4528-af23-0bfadec47df7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:194b1762-d6a3-4c4b-be72-e9713f517e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P35968"}
{"id":"d9f1878d-cc46-4010-993d-bc94d01c083c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188895","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:a071c42c-866e-41c2-8eb0-13c4b5a8f7a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:196","original_object":"UniProtKB:P61169"}
{"id":"32d4fe3c-1e9e-43d5-b1ab-2e6cfc0f6834","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41879","predicate":"biolink:affects","object":"NCBIGene:18171","sources":[{"id":"urn:uuid:464854c8-31fa-4a20-a3cf-e74c050e4ecf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2768","original_object":"UniProtKB:O54915"}
{"id":"7c10e844-3701-4063-913f-f8319502e946","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10358392","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:67f0db34-c19b-4bfb-96e6-9f79709701c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:66","original_object":"UniProtKB:P08908"}
{"id":"a3c61294-ae7a-41b4-b310-e91ddf4fb871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49869062","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:f2587033-9827-4e9c-868b-ab74421be1b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9493","original_object":"UniProtKB:P21453"}
{"id":"62465d88-851e-43e0-993d-827f86720796","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:92e0172c-ede0-447f-b5eb-23a799edf38b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P08912"}
{"id":"7ba9624e-c868-4937-b4ee-83e81c18dcc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91360","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:3ad6d7e4-61a1-4f55-9e58-7afb689237c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9328","original_object":"UniProtKB:Q15759"}
{"id":"9a501192-916c-4b23-be72-6be64054e99b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688690","predicate":"biolink:affects","object":"NCBIGene:7016","sources":[{"id":"urn:uuid:9083360b-1bb2-4485-8c52-361fe832976b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8118","original_object":"UniProtKB:Q15569"}
{"id":"a845b4f3-ddff-46c8-ad5c-4fede1cec374","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17639","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:83acf095-4885-47b2-884b-f6164eb5ff6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2766","original_object":"UniProtKB:P11473"}
{"id":"62370bfb-c64b-4940-bd68-f4d49f4e46b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:670a330d-a06b-4be7-9ea5-ac5f1487dcba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:Q5XXA6"}
{"id":"bdb02fb8-13ea-4bc8-89f7-28b58f27831c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143127","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:b0d07b46-185c-40f8-a612-8b9404e2769f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6019","original_object":"UniProtKB:P09619"}
{"id":"5e1aab9c-648e-4b79-89b1-8f1fd191afa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130961","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:71b598b2-68c4-44a6-8c48-b4dc8225d4cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2005","original_object":"UniProtKB:P32745"}
{"id":"7d3da5b7-34e9-4558-9b60-67a1206ccc78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134991","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:16a63787-2291-400f-ac53-f9dabb3d9f54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7191","original_object":"UniProtKB:P28221"}
{"id":"0acaee1b-2f27-49bd-b031-8af5e35705d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:55438","predicate":"biolink:affects","object":"NCBIGene:17171","sources":[{"id":"urn:uuid:53d6ae93-f43d-4342-866d-ad902847c26d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:582","original_object":"UniProtKB:P30554"}
{"id":"71246cbe-80ab-46c4-a9a6-05e5019baa58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LN4A42V962","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:01dd1574-3b09-46f8-90af-c9c495152583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10241","original_object":"UniProtKB:P35354"}
{"id":"b2a00f79-4690-4d63-acdf-fb405ec006c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:f528f5c1-7f9c-43fd-88a2-de9959a03736","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2182","original_object":"UniProtKB:P30560"}
{"id":"84162ecc-5693-49ac-b059-94d4bd614b72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121334520","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:50b26600-9cbb-4cf4-ae66-d987f80cb994","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10142","original_object":"UniProtKB:P42336"}
{"id":"405cc3b9-efb7-4d4e-b30e-624c7ae815e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XX8E5WP7FS","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:751ef0f1-bbef-477f-b142-fd9e6e62db1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10257","original_object":"UniProtKB:Q16620"}
{"id":"718d14f8-9109-4e44-bda0-50f26aee8ede","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:6a4d8121-da79-459a-8167-e3a9b4b4782f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P28221"}
{"id":"d29990d8-66d4-4d43-8f10-6dc692aa90dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2035","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:0900cc60-bbe6-4e07-826e-f0fe3f43465d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2035","original_object":"UniProtKB:P32745"}
{"id":"4c71eebd-b23c-4dbc-ac68-31bf81371896","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5280322","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:4b787584-d13e-433f-aa5a-1d9552078118","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3214","original_object":"UniProtKB:Q03426"}
{"id":"f63330f5-ba1e-4bcf-bb9a-66adf5bc4054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127790","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:20527593-bfe3-4184-b93b-1c94a7f97d20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11858","original_object":"UniProtKB:Q8NHX9"}
{"id":"a7e50a6b-beda-4f23-ae03-390f29eeb22d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:52860331-a8b0-43e4-8acb-b1950e696c63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P28223"}
{"id":"8c0aa240-4f0c-4ddd-a83c-9d1210324e02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145984892","predicate":"biolink:affects","object":"NCBIGene:4758","sources":[{"id":"urn:uuid:e999ce97-88aa-4924-8a43-a89944778cef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13013","original_object":"UniProtKB:Q99519"}
{"id":"f5adc60b-0014-4599-a5da-a75845b02d93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494540","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:9244a0b9-095d-484b-b52c-b58a84011fd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13635","original_object":"UniProtKB:P0DTD8"}
{"id":"a91b334d-5c89-4faf-ad67-28f8823d8a27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71598521","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:b2d89c80-0ff8-421b-9303-f3019c596445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7631","original_object":"UniProtKB:P08912"}
{"id":"c31d10d6-80ac-48a2-844c-cca62bc43adf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:db559f9d-0edd-4ce9-93ad-4444eeae30bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P23416"}
{"id":"62e9e9fd-0694-4685-b0da-833f7e06b8d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B4OQY51WZS","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:ed1dca89-0143-49d7-bc91-fa1d27821ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7844","original_object":"UniProtKB:P39900"}
{"id":"7eaa1eb5-83bf-4179-a957-3a424f715f66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:e1e171e4-16f7-4b02-a354-4675d42ba934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P43140"}
{"id":"33390e83-6c39-4d51-90ac-ee27c2cf9faf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:423d91f3-f086-4a24-98cb-d7371b9aafe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P08172"}
{"id":"9f7dd817-b982-49a1-8cc6-2ee989d40228","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91634","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:cdb8632b-9f1b-4f0a-9b58-9722cf49acd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1613","original_object":"UniProtKB:P41143"}
{"id":"ae5cdd5f-b37a-46ba-b79c-d209906b1a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167763","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:94ebf6f6-af4b-4ac3-9ce5-dd6796df50af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3998","original_object":"UniProtKB:P36544"}
{"id":"16b73851-d54d-4b5b-ab36-b3596806ea15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58056092","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:0378cc53-d711-463c-b0ff-d285f21a2b78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8085","original_object":"UniProtKB:Q9NWZ3"}
{"id":"d051388d-7cb2-4694-b1a0-ab1fa15fd010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92190","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:de3c8f91-5b6f-4396-bbd9-b8cdfbe11894","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1235","original_object":"UniProtKB:P25102"}
{"id":"f636229d-24d4-4b32-ac8c-4937dc1a4a19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47619","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:d39f43a5-2e84-450f-94e6-bf40732f35b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11627","original_object":"UniProtKB:P27815"}
{"id":"eefc35b0-792c-4060-bf70-88b898382aad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817466","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:c92f671b-982a-4ac7-87ff-44e74cba397a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4007","original_object":"UniProtKB:P36544"}
{"id":"313c1aa5-cbce-43a3-a6f2-9877b4baf4fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8944","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:b410c0d6-a308-4b72-a1c4-1ac574b80f11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8944","original_object":"UniProtKB:P07333"}
{"id":"e5a818f3-a588-4888-9e7e-1ea479c259ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13661","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:8a9413b7-a167-4297-97f6-ced9368aaab7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13661","original_object":"UniProtKB:P0DTD8"}
{"id":"51163237-514a-4216-b029-14bf4717bd0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34543","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:bcd452ee-7094-4859-abfb-e77bb6dcc0bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2168","original_object":"UniProtKB:P30518"}
{"id":"8c698b7c-da4b-4ccf-8951-64b456be25d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136042","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:fd0fd4f3-325b-4fb3-8fbd-d33adff0794c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9906","original_object":"UniProtKB:P27487"}
{"id":"4ac081b5-0549-4479-b9cb-9d3474be86a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86268622","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:10124a02-ebf9-458e-aca1-de34720dbf28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10163","original_object":"UniProtKB:P42336"}
{"id":"17bd8f4a-3050-4764-8505-7ec47083cfb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9161","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:0a0dfa90-5b64-4f8a-97fa-a829ac637cb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9161","original_object":"UniProtKB:P61073"}
{"id":"1692430b-73a6-4c15-bfe4-54b8e8ecc749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6111","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:34055dc5-da3c-41bd-94fb-d76ccc7ca9d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6111","original_object":"UniProtKB:O43603"}
{"id":"ebafbfd7-f59a-4e87-b4d9-478e65f8f951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42446","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:d49c04c9-1242-402d-b4ec-2593a0883b6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9420","original_object":"UniProtKB:P35354"}
{"id":"8d5f3a25-b0cd-487b-ab68-281c6c8e6a65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847377","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:80ee869b-191b-4629-82f2-c440331fddaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:74","original_object":"UniProtKB:P08908"}
{"id":"a2aa64a0-69d9-49a9-ac9c-53daeb709c39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:14739","sources":[{"id":"urn:uuid:be91d900-d1f9-4d8b-8b25-94e51bf4b7c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:P52592"}
{"id":"775c7914-7be9-4318-ace6-daf701015840","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168665407","predicate":"biolink:affects","object":"NCBIGene:5592","sources":[{"id":"urn:uuid:aa7cb102-1814-4adf-b761-8367a5443aaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13089","original_object":"UniProtKB:Q13976"}
{"id":"b9387059-5c1a-42ba-afd0-a1b02d5c19d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9P1ZGY0SE","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:9583f16e-d0cf-43a7-9999-72f715c7b968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1953","original_object":"UniProtKB:P35408"}
{"id":"7ebc53c5-1866-4153-8ac1-284f519635a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:148717db-0db9-4732-8f1f-859cc8ceacc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P29275"}
{"id":"ea28d7f6-765e-48df-b7f4-21c6ced3aacb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4W39NS61KI","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:dbf03b65-baff-4eaa-874f-22d14f3c0943","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7936","original_object":"UniProtKB:P42336"}
{"id":"aaf23634-e5f3-45f8-863f-7964b5828260","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311372","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:db0d08a6-539a-47df-918d-88cd392a19e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2050","original_object":"UniProtKB:P30680"}
{"id":"e8307e61-dec7-411c-b822-23a548ae8e34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45713","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:3c2702a8-22eb-4359-8a2e-dfeff38daa78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8741","original_object":"UniProtKB:Q9NYV8"}
{"id":"7b8302f4-f62f-45f4-8fc5-b67d1f419641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:25041","sources":[{"id":"urn:uuid:57511799-c649-4c7a-90f4-d9b66e4bf847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P51579"}
{"id":"ae1b227d-14b7-4b8d-95e1-ca4c6b6cb2ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9951490","predicate":"biolink:affects","object":"NCBIGene:5606","sources":[{"id":"urn:uuid:b8784895-1ee5-4b33-91fd-28a170d9831b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6006","original_object":"UniProtKB:P46734"}
{"id":"862951f2-f369-4a22-bb16-196419e486eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135018","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:af22bb78-c020-4d64-b12c-57cbb37a18be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1610","original_object":"UniProtKB:P41143"}
{"id":"80edf90f-54f4-45bc-9071-3d1e523ce8a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813891","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:18c56f1d-7295-42b8-b062-46234f2aa673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6122","original_object":"UniProtKB:P47211"}
{"id":"927fda0d-e3b5-4a47-b067-1a4d4990c8b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:832663U2NB","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:d6274791-8663-4576-9774-7fab82902288","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12039","original_object":"UniProtKB:P08235"}
{"id":"43ff6069-caef-4ab8-bac5-2255cde385f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3X8387Q25N","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:6782626a-b81c-4209-ab45-7bbfaec6ccec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10459","original_object":"UniProtKB:P52333"}
{"id":"08c7bc94-a164-4238-8b58-9679083e2032","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86302574","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:bcd94f06-4353-4172-aabc-667324c974e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12088","original_object":"UniProtKB:P08581"}
{"id":"013962bf-03a9-4644-95c3-8591797e6f48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11722867","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:57608c7b-37bd-4c8a-8bca-10f7d0424548","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3397","original_object":"UniProtKB:P23385"}
{"id":"3321f628-7728-40d2-9af5-09e147b5924e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146025593","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:a39ce5c5-0b3f-4a49-95be-7efca669cf3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10716","original_object":"UniProtKB:P0C6U8"}
{"id":"198dc255-571d-425a-88ab-aa70b26eb334","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:a7a5afe1-a301-4d6c-91d4-a886e252fd60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P28566"}
{"id":"2065f009-85f6-4f75-84fb-6713c9886caa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68621","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:34594061-c1f7-4632-b1dd-6c30de7aaf3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7876","original_object":"UniProtKB:P0C6U8"}
{"id":"e088fad5-af2c-429c-8f64-30ddb6363f71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:912","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:1869ab93-3dd7-4f35-bdcb-4b9884df70bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:912","original_object":"UniProtKB:Q60748"}
{"id":"b352e7c0-7d82-4ab0-bc9e-949f188985e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2052","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:6b302870-4191-4dbe-8432-4cc8a176cc47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2052","original_object":"UniProtKB:P30875"}
{"id":"a07f513b-506b-4f69-8d16-8616981eda06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92360","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:baebcbd7-db57-4f47-b1cd-d95723832aef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:165","original_object":"UniProtKB:P28223"}
{"id":"8951fb13-1618-4081-a5dd-bbaf3d944880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17597","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:3fc89ddf-a2df-4310-b67d-3a258b27c57d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13597","original_object":"UniProtKB:P0DTC1"}
{"id":"c2d96322-ba11-4d6f-a48d-3734c629d19a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O9BP19HZ3Q","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:6221e15b-6d35-415d-b85e-0a789aa904d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9798","original_object":"UniProtKB:P47869"}
{"id":"c793b05d-1660-412b-8b1b-30d70adf3350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5263","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:3af564eb-781f-4549-a38b-ddd5c9edac7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:402","original_object":"UniProtKB:P29274"}
{"id":"93af1391-981e-40e3-8e1f-35d1f77f9604","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H84XT1COAU","predicate":"biolink:affects","object":"NCBIGene:21390","sources":[{"id":"urn:uuid:db47112b-97e2-43cd-bc06-9ba5920a3320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1976","original_object":"UniProtKB:P30987"}
{"id":"0aad534a-5eb5-4106-a6e6-bf55fe068d82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91755","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:8c055738-2195-45dc-8a22-b46b77dcc1fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6638","original_object":"UniProtKB:P21397"}
{"id":"a93ff983-fbe9-4f73-aa52-f8b4dbec5a02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:769","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:c4972091-9dbf-4ed9-9902-e0a97c849d69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:769","original_object":"UniProtKB:P51681"}
{"id":"d060d763-601b-4c46-8739-fc0186fe4b1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15854","predicate":"biolink:affects","object":"NCBIGene:9312","sources":[{"id":"urn:uuid:6a6d4f07-3a98-484d-b5ca-1eae6b103fb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2510","original_object":"UniProtKB:Q92953"}
{"id":"153f9da5-973b-46a7-bcbb-eb7f65671622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197107","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:d7da69b3-5dbb-4578-a583-c7391afa833b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7906","original_object":"UniProtKB:P07948"}
{"id":"a663558f-1979-40b2-a956-f5865e7a0db8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13749","predicate":"biolink:affects","object":"NCBIGene:6862","sources":[{"id":"urn:uuid:204ffdfe-22fa-44ee-ac98-54b384c07d3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13749","original_object":"UniProtKB:O15178"}
{"id":"850a6bc6-e018-40a2-af7c-4ed14e334c50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13848","sources":[{"id":"urn:uuid:ae4cafed-6afc-4983-aa13-cf7a84b963b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:O08644"}
{"id":"95a4abdc-12d0-46b5-9575-cf4e2da005d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136970071","predicate":"biolink:affects","object":"NCBIGene:80168","sources":[{"id":"urn:uuid:408e95ce-d28f-4027-92f7-527b8819df8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12971","original_object":"UniProtKB:Q3SYC2"}
{"id":"6029b9d0-4674-4646-87a5-31c1ee8f32cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7457","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:5c58e9bf-a2ac-4daa-8fca-9943163bbe94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1628","original_object":"UniProtKB:P41143"}
{"id":"08c834b0-caf1-4174-92c3-be1e687f4562","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46228996","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:fba6af24-5b55-4617-b867-6b88ffb22ef4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13864","original_object":"UniProtKB:Q9NYV8"}
{"id":"e8e1760f-0b44-40e0-8c5b-e0defeafe761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13887","predicate":"biolink:affects","object":"NCBIGene:3566","sources":[{"id":"urn:uuid:bcf8f13c-a5c6-4425-a740-ecebb2fc3afc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13887","original_object":"UniProtKB:P24394"}
{"id":"247c0053-68bf-4c8f-8bf8-ea375597e120","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4293970","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:b280298d-ff8b-4b39-aba3-4fe12f56846a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10151","original_object":"UniProtKB:P42345"}
{"id":"fe7c5977-2cdc-42dd-91bd-6deaa90852ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131512","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:f716e4c6-6967-42b6-82e4-7bb760d08294","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5281","original_object":"UniProtKB:P27338"}
{"id":"3b1c57f6-bc86-44cd-841d-ef0ce7cee3c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136203454","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:5419e28a-6463-4a9a-be29-c82997b1be53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4225","original_object":"UniProtKB:P51575"}
{"id":"ce741a16-11f4-4e34-8e97-b0827730caeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6149","predicate":"biolink:affects","object":"NCBIGene:59307","sources":[{"id":"urn:uuid:c7b7d0f0-4859-4864-9878-cd98c74c3915","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6149","original_object":"UniProtKB:Q6IA17"}
{"id":"d8702ea4-3888-4abd-9c0d-20a2c54fe20d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:170007","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:04f1a5fa-d926-4d3b-80eb-d62eee1ae2d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11503","original_object":"UniProtKB:Q9NYW7"}
{"id":"31f62102-ecb0-4ae3-b624-b65fd6fd79f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16973","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:93639f83-c6cc-4446-a934-8a59fd526191","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2871","original_object":"UniProtKB:P08235"}
{"id":"2d5ab572-02d7-4775-920e-c30eb09550fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:bb8252af-2e63-4ac7-9cbe-800c8ac07e1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P14842"}
{"id":"d6465461-5544-47dc-af42-3700d28a15d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13817","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:9df521bc-2904-4fb7-a42f-ac5e0855f428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13817","original_object":"UniProtKB:P41143"}
{"id":"39e45285-1718-4291-bea0-6fcc565cacf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324620","predicate":"biolink:affects","object":"UniProtKB:P31387","sources":[{"id":"urn:uuid:e8d03561-7be6-4f42-a2fd-20c7be43e412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:262","original_object":"UniProtKB:P31387"}
{"id":"3910cac2-bb20-473d-8a21-67e254c38daa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9311","predicate":"biolink:affects","object":"NCBIGene:3604","sources":[{"id":"urn:uuid:b6330373-a90c-4b5f-b0c0-6c140b009718","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"antibody_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9311","original_object":"UniProtKB:Q07011"}
{"id":"9aef383c-83e9-42f2-9d08-2d91403db250","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:6643fe1c-83a6-413d-877d-f2a63c52a313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P28566"}
{"id":"502c2836-8db0-4e3c-b578-c493b261f846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5781144","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:df7b0a6c-ae00-4ee6-8026-6cea6fb57ca8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11564","original_object":"UniProtKB:Q9UGC6"}
{"id":"5c39ef8f-f472-414c-a02e-c3dbe70fd256","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64156","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:a22c1e10-c9e2-44b5-aed9-4f3a86bb9bdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1250","original_object":"UniProtKB:Q9Y5N1"}
{"id":"ac1766a7-7f95-4652-8c30-256688a710d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2211","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:1eea4b87-02d0-4788-8560-29e8901020ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2211","original_object":"UniProtKB:P47901"}
{"id":"16699cf8-a6d3-44b3-9bb3-c952763fb08b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233446","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:1e4f949c-8e75-4968-af48-214f03819087","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12630","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"9bf7d7b5-94f1-4804-9406-b84f88a0d00f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:074b17fa-c433-40ba-9d81-07c7ff002cce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P21728"}
{"id":"2c05e6a2-bb2f-4fbc-b78b-b6cbd26c6af5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16193817","predicate":"biolink:affects","object":"NCBIGene:11313","sources":[{"id":"urn:uuid:b5b6e6ab-f08c-4d47-bc96-736e4293894b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13413","original_object":"UniProtKB:O95372"}
{"id":"a4a9fb06-9a99-41d6-afd9-8bc407a31963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:c322864e-d880-4acc-9970-b168035d5ee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P36888"}
{"id":"1a6fb42f-202c-42e4-92eb-a097f8c109c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:92a6b554-d9f3-4265-b620-0ae348f90d85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:P43116"}
{"id":"858dfb12-6c83-437c-9192-77a1f770a01c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:2cf90709-68ab-48a7-af84-8b94448bb21a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P35408"}
{"id":"85b7c56b-f628-401f-bf6d-d6836a107876","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:820","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:c15a93db-4e97-4986-a81a-ee943f70f580","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:820","original_object":"UniProtKB:P25025"}
{"id":"21504416-d277-4b04-b28b-6fe8edfd04a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9875034","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:ea5b6920-01b4-4b6e-8622-6172a471acbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2106","original_object":"UniProtKB:P29371"}
{"id":"3149bd94-c883-4d54-a5fb-7abdb1fb26dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4779","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:7e903277-6ad8-4daa-a033-748020cdf841","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4289","original_object":"UniProtKB:P23416"}
{"id":"6fe306c7-127f-4fa8-a834-c161e3397024","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:102166","predicate":"biolink:affects","object":"NCBIGene:684516","sources":[{"id":"urn:uuid:c98c6541-ce42-4bcb-ad9d-52fa2d7a7f03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2579","original_object":"UniProtKB:Q63734"}
{"id":"6eabfcde-087f-4647-9d1f-dcf54b504a8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15983171","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:97089cf2-f168-468c-983e-222dadd561e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11280","original_object":"UniProtKB:P04201"}
{"id":"248d901a-caf9-40ee-a72f-6e3e171bfe97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2547","predicate":"biolink:affects","object":"NCBIGene:3736","sources":[{"id":"urn:uuid:6a1fa353-e5ff-440e-bad1-714d504eb0ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2547","original_object":"UniProtKB:Q09470"}
{"id":"514f5506-6f2f-483a-bcf9-eae5f6ae1742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132157920","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:b0c12b2e-3469-42f1-9a2d-c00efe6bf690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11164","original_object":"UniProtKB:Q02127"}
{"id":"1d94bf5f-5842-45c1-8cd5-b380976fde6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9827219","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:825c8b89-4556-4481-9638-4fd9607d4f51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7894","original_object":"UniProtKB:P12821"}
{"id":"20d32dbb-a6f6-4053-b22f-8575f5dc5821","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25207521","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:50d7ccbb-055e-4db6-8038-0e9e190702ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8163","original_object":"UniProtKB:Q13464"}
{"id":"16276abf-4b61-4af3-a9f7-acf76f0a96f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52392","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:95c1db5b-e6d9-4702-af86-80cbfa249fb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:729","original_object":"UniProtKB:Q9Y2T6"}
{"id":"e3c7fd70-baae-46c2-8fdc-19a09dc4aaa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15996","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:3d21c610-9ae1-470d-92ed-656437dcb047","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1742","original_object":"UniProtKB:P51582"}
{"id":"a024bf86-cd44-476a-bb4e-03f2b9b28833","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11206290","predicate":"biolink:affects","object":"NCBIGene:1548","sources":[{"id":"urn:uuid:12222cb5-1911-4d25-861e-db3d55ce9f5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8755","original_object":"UniProtKB:P11509"}
{"id":"d6811a5e-f93e-47a4-b05c-de1021a35e99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:497U7679T0","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:4e91a23a-dcf8-4fa8-9a84-77c8125eee05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7688","original_object":"UniProtKB:P00734"}
{"id":"c9efd86a-b7e6-4af4-b8ac-db688e712bfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53494934","predicate":"biolink:affects","object":"NCBIGene:290","sources":[{"id":"urn:uuid:e13bebe3-fc44-4f9b-9d4b-ccf5f15785c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8565","original_object":"UniProtKB:P15144"}
{"id":"893d6bcf-f185-4507-b5d3-3fb5e5124661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50902958","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:d0e9facc-2f4a-4808-a142-f9c5b64dc4e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6262","original_object":"UniProtKB:O88703"}
{"id":"e1f208fc-0439-4528-b2fd-0c18be03741c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221654","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:4f6c5102-f8ae-4816-be51-32aa5cf9be44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9495","original_object":"UniProtKB:O95977"}
{"id":"73f37fd7-0c01-4d42-ac87-e0eb49b4dd5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:62151","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:e585a084-4170-4819-8b48-d90e3df77675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2466","original_object":"UniProtKB:Q8R455"}
{"id":"4f04cf0f-6d9e-408f-9186-c84fc1dc27a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46225540","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:b49474d9-9da4-4915-9403-a127349ed803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8181","original_object":"UniProtKB:P31749"}
{"id":"0d67861b-7cb2-47db-b51a-b3e9ba8c5747","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801158","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:77ba243c-469f-4c1d-95ac-727ad37e0ca4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9684","original_object":"UniProtKB:P35354"}
{"id":"6dfdff48-ce2b-406d-a8d8-390d45a589ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:50654","sources":[{"id":"urn:uuid:0916802e-5fbe-434f-985e-9d2abcaea745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:Q02765"}
{"id":"bf5980e9-1a4f-467a-9856-2dce9d11ab09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5486828","predicate":"biolink:affects","object":"NCBIGene:18439","sources":[{"id":"urn:uuid:1fdfc097-349c-40d7-ad4c-5a8a863e5689","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11234","original_object":"UniProtKB:Q9Z1M0"}
{"id":"40319591-4639-4251-a92f-8514e8a904d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4464","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:71544fcf-a132-4d1f-9334-0d2d2fe937f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1210","original_object":"UniProtKB:P35367"}
{"id":"51187e4c-6ec8-452e-80eb-fe0398629702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4868","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:67c0fb85-af96-4fd4-979b-aba1d5c85f9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10338","original_object":"UniProtKB:Q99572"}
{"id":"b4305aa0-9015-4c7f-aad9-cd1e5349665d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95255","predicate":"biolink:affects","object":"NCBIGene:50838","sources":[{"id":"urn:uuid:e143d0a6-2af4-4040-bf93-221abb6b73dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12433","original_object":"UniProtKB:Q9NYV9"}
{"id":"36f40b25-3f0a-4343-bf7f-676628067c66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46191567","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:7978a926-1e65-4f55-b36f-cba4f2825bb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12757","original_object":"UniProtKB:Q8NER1"}
{"id":"b5bcbcbf-f361-4f77-a46f-02fc1fab1e4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:89310","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:e93a487e-ea45-4ae2-8118-07845cfe1ec0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1946","original_object":"UniProtKB:P35408"}
{"id":"099e8414-d11b-4e2b-b195-ad659cda3a16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9150","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:c20b6194-c920-4c7a-ac80-352f2bacd397","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2955","original_object":"UniProtKB:P51639"}
{"id":"d79b58c7-da03-42c6-bd01-c5f37725cbd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176958","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:c48248a6-ca59-4db5-b01f-3a0b6e709c3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1609","original_object":"UniProtKB:P41143"}
{"id":"9dc0e59f-68bb-4ebd-92ba-a29efc4fbedb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813905","predicate":"biolink:affects","object":"NCBIGene:259230","sources":[{"id":"urn:uuid:43fa8a6a-3d9b-4872-8f53-7deb8fc9c3df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10054","original_object":"UniProtKB:Q86VZ5"}
{"id":"d56929df-7eaf-4dc2-aa36-7994ade8976f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B67UFT75QS","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:c5b9bb0f-4df9-4d49-986f-d1a364fd6dad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9821","original_object":"UniProtKB:P56817"}
{"id":"68ee8d91-f3d8-40a3-b442-8cd23f4cf2d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10308720","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:e026344e-eea6-4c26-8d4c-79cf93d78b91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9678","original_object":"UniProtKB:P51679"}
{"id":"0e2b0b63-cd09-4f08-8b8f-86dc46ed2015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70735","predicate":"biolink:affects","object":"NCBIGene:24473","sources":[{"id":"urn:uuid:56073297-2122-41bb-a249-a69fd83517ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7461","original_object":"UniProtKB:P19327"}
{"id":"7070a5d7-2b95-479b-a634-e17408fa7f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91365","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:fbbe52a0-a17d-431b-89db-e3c2bb16cfc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8466","original_object":"UniProtKB:Q96GD4"}
{"id":"aef6f95b-9c4c-46ef-8a86-e6395aed36b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229221","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:abaaa301-c5c7-41ab-8da3-9c0c81ac0986","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9428","original_object":"UniProtKB:P17948"}
{"id":"4bd7c4e9-00a0-4eef-91d1-61c92a4adbc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2542","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:2caab5aa-d675-4ce6-8140-e3095591bc54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2542","original_object":"UniProtKB:P54282"}
{"id":"0b105c7c-f0dd-4f6f-8c29-fe7293f14d94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440621","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:104bdcea-12d1-4e7e-aa44-73dd4e1edc8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1325","original_object":"UniProtKB:P41968"}
{"id":"33dc4932-76c6-4b59-864a-7b5cfed058ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R1XBQ6NTFR","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:daa40a12-a739-4e0d-a911-1ff536c8b6c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:154","original_object":"UniProtKB:P41595"}
{"id":"abe2201f-3178-4ac8-a130-ad916c37e6fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5283035","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:8c3b1794-7b4c-4e9f-8f80-341899889dfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1877","original_object":"UniProtKB:Q13258"}
{"id":"23d4e960-9d37-44e1-98cb-0c2fbd1e47be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137701512","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:8bac2cda-e598-4434-8d2b-676877f057b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10673","original_object":"UniProtKB:Q9H2K2"}
{"id":"882b59e1-e1ee-45a6-a139-c461fc3fea69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44300749","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:1a5abfbd-afd8-49cb-ae41-e770471ceef9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3788","original_object":"UniProtKB:P30550"}
{"id":"3bb21931-51e6-40e8-a1b8-190a02026cb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8973","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:42c7ee34-f66e-4d67-a142-9df988cee687","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8973","original_object":"UniProtKB:P48546"}
{"id":"4fe183cc-292c-4afa-b847-faf8fc568096","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996520","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:9c04da5b-ed3f-49e3-b114-695304f383f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10581","original_object":"UniProtKB:Q9Y271"}
{"id":"a9a4c63e-ba97-42b7-b2d5-fd86a72a3e62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817415","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:36adf365-71ac-44a6-9c40-b727e2889a49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1482","original_object":"UniProtKB:Q9Y5X5"}
{"id":"dd0ebf2c-776f-49c4-aa04-f442acc3fcfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J8RN2W0HK","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:93184d0b-0795-4b85-bb4f-ccd6ea862032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9962","original_object":"UniProtKB:P13631"}
{"id":"f25ef644-ba0b-403c-8a37-98fc8f3c3e2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:bf442694-d319-41ef-b6a0-e921adbe3199","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P14842"}
{"id":"e3c06f3a-e324-4861-a78d-a8b0289cdf4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:d2c81fd0-8d11-463b-b096-eac45788f612","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3977","original_object":"UniProtKB:P36544"}
{"id":"5d430d03-4f57-46e3-b152-4fe5ceb1559e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2057","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:558551fb-4a84-4911-a6b5-40f683cd767f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2057","original_object":"UniProtKB:P32745"}
{"id":"ff8602c6-b928-4253-8c73-939ad7391a2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15599147","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:b841f0c8-99e2-43b7-92f6-96e148621a18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6560","original_object":"UniProtKB:P30542"}
{"id":"7fdd7b28-c275-435f-90c1-98f6bf5af937","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11624601","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:2c69416c-7438-4737-a183-0a9dc8d45452","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5998","original_object":"UniProtKB:P45983"}
{"id":"0573f51e-67f7-4e85-8d37-8bfa055e9400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25025860","predicate":"biolink:affects","object":"NCBIGene:260319","sources":[{"id":"urn:uuid:fbd02900-8846-49a7-a49c-b2dc93e625e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6188","original_object":"UniProtKB:Q8K418"}
{"id":"a637bc4f-6b0b-408e-b61e-b1b366feb00f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947012","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:d6180dfe-c077-48b2-b62f-a80465f6e09d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3130","original_object":"UniProtKB:Q02769"}
{"id":"613c5a93-941b-4990-82e1-7341260a5c74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142437","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:ce7a9b31-ed33-45e6-b8ef-fc7d56370f5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6469","original_object":"UniProtKB:P00734"}
{"id":"2340b215-81a1-456e-8b8b-d27197164818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:755659d6-7886-40b7-aefd-680446ef8365","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:P53779"}
{"id":"a948794c-c97b-4eb5-9644-d627d801a390","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:ce313eed-adf5-444f-b92b-c0ba98ed69c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P32305"}
{"id":"5e176c7e-f25e-454d-80c8-2e4c45fc74a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58368068","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:48ebaa91-42da-4c50-bcb1-74299c8d178c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6410","original_object":"UniProtKB:P31424"}
{"id":"9823b723-0251-4edd-baba-7d6af7090655","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N62TGJ04A1","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:46aff167-60ba-4d49-b0ef-4289063c1e98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9894","original_object":"UniProtKB:P08235"}
{"id":"e78d8d80-ae9e-439c-af61-a5cb9c9546c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:fbb5cdf6-49ed-4cba-ad4e-202723e284ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:P31751"}
{"id":"40ae6081-31ff-44e1-85eb-2a3ba8904c25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58945732","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:21d172c9-304c-4780-a00d-9b8b7ecf00d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12126","original_object":"UniProtKB:P00519"}
{"id":"56772bcc-1237-44b9-93c3-bc257ec4de48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321165","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:19267b33-289d-4227-8c99-71b8f4aaa927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10185","original_object":"UniProtKB:P41145"}
{"id":"67a7a59b-a6a0-40cc-a934-b299ae650c74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138424","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:cebd66b5-eb23-4d2f-b82e-bea0ae822b09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2508","original_object":"UniProtKB:Q9WTR1"}
{"id":"f5a31d80-54cc-4806-b5c5-286408e5109b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993637","predicate":"biolink:affects","object":"NCBIGene:64324","sources":[{"id":"urn:uuid:a5560072-950b-4d5e-b418-73655d69f138","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12352","original_object":"UniProtKB:Q96L73"}
{"id":"0b72ab95-2cc2-4b0d-940d-1abb7ef9ba2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1505","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:bb0b7098-9853-42d2-b6de-62d745ffa5e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1505","original_object":"UniProtKB:P21555"}
{"id":"9637bf9d-b50c-49fe-b200-4522dd2d3a2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947056","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:e0575b07-a40e-4997-b9d9-c0546053e514","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3063","original_object":"UniProtKB:P37268"}
{"id":"bc2a61e9-968d-4dc0-adf5-572c088b816c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141046","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:790df2c5-5c1c-4caf-af8a-5b9a454c8cbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1926","original_object":"UniProtKB:Q62053"}
{"id":"11a80e8b-0ec8-4977-9c37-01b18c8c7322","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9975297","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:b65a91ee-bb13-4f74-8d51-166e6f8d940d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8700","original_object":"UniProtKB:P37231"}
{"id":"3eab71fa-8b1b-4653-93bf-7a2830da9107","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:642dc5e5-f6ed-46ee-a94a-435dd431e93d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P28335"}
{"id":"2af4862f-ec19-4c06-a71e-4502414a308b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233305","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:55b8a35f-a48a-4e70-86fb-3c4e53a3c466","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9368","original_object":"UniProtKB:P11309"}
{"id":"f3bffa3f-49b9-4468-b750-830ed2f13d61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1799","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:7eea646a-1270-4f4b-8bb4-ee0f18296660","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1799","original_object":"UniProtKB:Q03431"}
{"id":"6bade86d-52f4-41b3-a511-9cc5086de7ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:522fe478-4c1b-4469-a98f-203b0232b99e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q13547"}
{"id":"d7cd5abb-3e4f-4022-a084-a02756a1055d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88358","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:9840e01e-752c-4459-8463-b8264aa06cfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1731","original_object":"UniProtKB:P41231"}
{"id":"b17aa9fe-0693-412b-8c52-b0f5c831d79b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:6a9fbbe6-a94d-4ffd-a67b-f8b7e78e62e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:P51788"}
{"id":"b989d0b0-7f97-4ef9-ba0b-69b77421dcd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:117155","sources":[{"id":"urn:uuid:c52c5cd8-8f75-4843-a9c6-0cb06d3eae95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:Q96P56"}
{"id":"2bea53d3-4cf4-4437-9ab2-3cca5ed4c9cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL285043","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:fdec36d1-37cd-4264-88f2-cdaa00f82ac4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1408","original_object":"UniProtKB:P31423"}
{"id":"ecf929dc-ab68-4023-b53c-ccf5b4f4220b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:65V47O9NOP","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:53e5d711-ccdd-4f6e-ae6c-9f971760fb0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10232","original_object":"UniProtKB:Q9Y5N1"}
{"id":"1514ac85-afaa-4934-8d2c-00248b4bca16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4575","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:252b61e4-4ff2-41c4-82c1-ce9f2cfbf37e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1616","original_object":"UniProtKB:P35372"}
{"id":"06517751-0424-4b27-ace3-88d005857464","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4T36H88UA7","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:a64b89f8-6331-417a-bc6f-2ac675b27697","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9043","original_object":"UniProtKB:P15207"}
{"id":"885451c8-d893-46cd-8fe4-31f347532c0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311352","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:caf924dc-429f-4321-b969-263486efda44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:620","original_object":"UniProtKB:P28336"}
{"id":"714ef9a8-7d26-4c0e-ba84-d999057a6de6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2170","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:5793add5-bd96-4046-8e96-9a16d3e21ed7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2170","original_object":"UniProtKB:P30518"}
{"id":"1da7cb3e-60ac-4c9d-87dc-d8dca547f45c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57664406","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:65dec691-7cec-415a-a677-e64a84941cc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6938","original_object":"UniProtKB:P08173"}
{"id":"81f3c924-6ad4-4566-b0a9-8b17878475e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2211","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:2d5cbf75-c48d-49c7-b6ec-c2d9bce78b73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2211","original_object":"UniProtKB:P37288"}
{"id":"3a42dc99-dc74-4acb-bfdf-667a256de7be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177849","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:43b83dc5-ded0-4bb8-ae29-dea02935df24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10408","original_object":"UniProtKB:P32245"}
{"id":"36c049f9-227c-4a85-ad80-05ac12873c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75998","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:533b2c9f-1542-4147-9a47-8633737839e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6495","original_object":"UniProtKB:Q02750"}
{"id":"deb52252-6da2-475b-942c-10158f4ac0e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:77f328ad-10ac-41f7-b46f-07a5427c0654","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P28223"}
{"id":"0f2088a9-1621-4598-88bf-f5bd77cc913b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6242","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:cc92d43b-3a45-4e20-8059-75f8dbcbf347","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6242","original_object":"UniProtKB:P25090"}
{"id":"ca517472-ef12-4a42-bd43-020fece999d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17347","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:3fda1998-009f-41dc-898a-20fbbba82d53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7100","original_object":"UniProtKB:P10275"}
{"id":"a7f5ae69-8883-4a71-a7c6-829d68935cd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1813","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:829cd63d-dacd-41b5-8bf8-880eb3277f4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1813","original_object":"UniProtKB:Q03431"}
{"id":"37e9e688-9bef-4bce-b294-fd37ec9b8d78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N18ZH0M4NP","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:45df8bc9-98d7-428d-9133-b9d1ab7023b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1653","original_object":"UniProtKB:P33534"}
{"id":"222d3d9e-8070-4666-a3b2-fc187ecaca2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:4d030da5-09d8-422d-b1a8-cab52949940d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:P43405"}
{"id":"e21a7eb5-6143-41f6-8527-c7a6de99c6f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5639","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:a4ecadc8-b745-49e7-8b93-b3d703e1186a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5639","original_object":"UniProtKB:P30874"}
{"id":"7b57f47d-9479-460e-8f07-b18332b071d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92409","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:8f737c92-92ce-4af4-8f06-0899cb26014f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1441","original_object":"UniProtKB:Q14831"}
{"id":"3fd2bf27-180c-407e-87b4-678cc0aa5b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9M363811V","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:84b6ae2d-a323-4e7c-a3ca-0cc6cd11537b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8104","original_object":"UniProtKB:P21802"}
{"id":"709ff473-686d-4230-bee2-845489f3e43c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124959","predicate":"biolink:affects","object":"NCBIGene:4846","sources":[{"id":"urn:uuid:dfe0cd2a-8a77-43ee-9d7f-3868ab7a6bc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11467","original_object":"UniProtKB:P29474"}
{"id":"acc21d8e-bd45-465c-96e4-6e4e5f6300c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:721809WQCP","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:a5359ea0-3dbb-4ba4-9921-9bf9eb516f85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5263","original_object":"UniProtKB:P11309"}
{"id":"ad9a74a0-a363-4e3f-9a28-3028bf96edc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:b08e9618-3424-4751-9a50-16f4b2906eda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q9NRM7"}
{"id":"7ea4507c-3e0b-4f27-8e6e-4b028f82dbbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129234005","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:63e99a2e-a582-4d58-aec9-49b6c330f5f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12239","original_object":"UniProtKB:P51813"}
{"id":"f802f03f-f688-40c4-9c1b-0d0937d6c68c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75124305","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:145664b9-c976-4c29-9252-886a4167a984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7522","original_object":"UniProtKB:Q15059"}
{"id":"c1b89c0f-096d-49f1-94b0-c9c0fdb45896","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4B93MGE4AL","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:1ba34aea-33c6-4f87-a42e-b2a746bfaa9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9786","original_object":"UniProtKB:P21802"}
{"id":"7f9ef9cd-a702-4d3c-b0e2-f2aa797fe39f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UR18YJ97SJ","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:5c3eb944-61bc-423a-bfa0-13ecade2bc1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6936","original_object":"UniProtKB:P56817"}
{"id":"e3030f48-bbab-4134-af33-c0e98401dcdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5288811","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:5309864e-00e3-441d-888a-768791b62478","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4005","original_object":"UniProtKB:P36544"}
{"id":"d0d30ee8-0cde-4f8f-b61a-fe270d0730b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11306423","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:0f0dfb3b-5c4f-46e3-bcd0-54dfda546864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6068","original_object":"UniProtKB:P34995"}
{"id":"05d40a1f-e2d3-4780-a3b3-20794fb0f58c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GH34I6261","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:a321c67c-92f6-44b0-8e3b-4c13cad215b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5866","original_object":"UniProtKB:Q92847"}
{"id":"47252b00-290f-4df4-b31a-63ed0ad7f76a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311225","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:e1b34957-33e0-4007-8bff-0a41b80303d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1918","original_object":"UniProtKB:P35408"}
{"id":"c55885d8-9e1c-4d21-9e52-8e2937498574","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11965767","predicate":"biolink:affects","object":"NCBIGene:1524","sources":[{"id":"urn:uuid:cfb6b013-2a39-4f9c-92a7-9396b08f753d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13739","original_object":"UniProtKB:P49238"}
{"id":"90ec0301-a27f-4589-bf0e-4c2bf16ba627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:95b3acbe-0868-4c0a-a36d-969fc1c70567","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4262","original_object":"UniProtKB:P78348"}
{"id":"b92b1f0e-4631-47de-bf8b-70710121e8ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24794417","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:37e17bee-4102-4d48-a90a-09b9bd4aa314","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4168","original_object":"UniProtKB:Q14957"}
{"id":"0771b434-ec0f-42ba-9f4a-0526eea53bd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:fda9ee59-562c-4a27-b0b2-27cd4c02ac8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2181","original_object":"UniProtKB:P37288"}
{"id":"3c80c059-7600-4b85-8f82-9e7b27c46593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:9aa409bb-81e2-44ab-8b44-1982e8ae7b88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P30994"}
{"id":"b1e5efb2-9a5a-4a80-abe0-5e3ee133d0c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42549","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:736ada79-a2a5-4571-9f95-125b66a81090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4070","original_object":"UniProtKB:P42262"}
{"id":"f40a1b67-99ef-4e6a-bb6c-5b5cd74914b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:0eb7ee03-6eec-44c4-99d2-f296fa18eadc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P35408"}
{"id":"eea589e0-d385-42db-a778-eef730403ae2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DPT0O3T46P","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:0fb4eb6e-c537-494a-81fe-e2a6a2aeed65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7499","original_object":"UniProtKB:Q15116"}
{"id":"4b89bad5-7d94-4d67-9cc0-89b920cc125d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:93c4089b-ad3f-4a4e-88ea-f9f0795777a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P20309"}
{"id":"c793f541-507b-4d8d-b1c8-3c759f603c2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25221108","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:8c094663-502e-4252-ab41-4941280b286c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7822","original_object":"UniProtKB:P11229"}
{"id":"0cb2bfc7-34f3-47b2-ba96-6b16f12d3031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3601086","predicate":"biolink:affects","object":"NCBIGene:66026","sources":[{"id":"urn:uuid:1b4580c2-1a40-4602-a8eb-0650d0164cdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4294","original_object":"UniProtKB:Q9ERZ8"}
{"id":"3f691be4-c0c9-43ea-b313-c08392e92acb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567102","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:981732ac-8965-4d6f-8c05-bcd94e63656a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12661","original_object":"UniProtKB:Q02750"}
{"id":"d85f642b-3274-45d2-aa7b-2291c1a3e70d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10918703","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:d272ef5b-d1fd-46f1-bb81-9105b82e0978","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9006","original_object":"UniProtKB:P41143"}
{"id":"f00cd490-cfc7-4926-a62e-ad4b0d5eaa46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10918703","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:24ad2989-cb84-4d94-b336-be1e72026c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9006","original_object":"UniProtKB:P35372"}
{"id":"a33dd020-5ecd-416b-b8ee-dcb69682d1fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5DKZ70636","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:aeba23e8-7b1e-4298-8e34-6e72c342c958","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10097","original_object":"UniProtKB:P42336"}
{"id":"36029996-bd47-442e-9e19-7c155a5fa734","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JTZ51LIXN4","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:f54c13ce-5989-46c6-b2c7-e5f12875370c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11413","original_object":"UniProtKB:P51451"}
{"id":"77033d67-4283-47e3-9f43-57df61f0b3ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:08d2a9e2-eb71-4131-810d-ed9a68b39a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1052","original_object":"UniProtKB:P57789"}
{"id":"4825b126-36b0-4aad-895a-99c46f7f6ee1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:7463974a-cd05-438d-9d3a-70c96e903593","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:Q9H3N8"}
{"id":"c63db9c2-023c-461c-999b-08589b4c3eca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IA262432Y9","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:f8c034a4-fe6b-4eec-8d85-025b9c426c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4304","original_object":"UniProtKB:P42261"}
{"id":"7f2ab5e0-517c-4ac8-b025-c9738768de87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155103226","predicate":"biolink:affects","object":"NCBIGene:5771","sources":[{"id":"urn:uuid:bb550eb2-a820-47dd-9af9-09d5daaae3d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13005","original_object":"UniProtKB:P17706"}
{"id":"1d85a17e-3b2d-4758-8652-f4b711baefcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25016538","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:05e03735-49f0-4378-8b42-084c6c67a937","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5862","original_object":"UniProtKB:Q923Y9"}
{"id":"e1b9dbb8-a632-4061-818a-295bee881f15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11527","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:171049a5-ae18-4c02-867d-40953a7c6e63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11527","original_object":"UniProtKB:O43613"}
{"id":"af521abc-18af-4afc-b77b-c29590e12921","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:573","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:a9208c71-4124-42f1-aade-ca81ddf9fc42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:573","original_object":"UniProtKB:P21730"}
{"id":"d5a3439a-84d4-4005-8c83-36f1c88708d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50861","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:0cd7a675-8b3a-417e-a93a-117a7622c85a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5820","original_object":"UniProtKB:P34995"}
{"id":"db0f027c-8aac-4e08-87e8-0c8c7c4d05ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:b79fe5bc-4de4-420e-90d6-05a9ded9593c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P21802"}
{"id":"5cc1dabd-a158-42cb-ba6b-202219c3bb6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231598","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:b905b9a0-00ff-471b-9c57-33db0fc991f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7011","original_object":"UniProtKB:Q15910"}
{"id":"731aea6e-8bef-4ebb-a3cb-5f0e085fece5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54760053","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:07741fb0-e8a7-4aa7-b7f4-a0fdfd4020e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8095","original_object":"UniProtKB:P16234"}
{"id":"ec218248-09d6-4945-a86d-a0028d152aa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:5e2f17a7-21db-46f5-825f-cf33da40bdb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P08913"}
{"id":"295c8570-0d9d-4f83-9197-ab18f1e4feba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:74T7185BMM","predicate":"biolink:affects","object":"NCBIGene:930","sources":[{"id":"urn:uuid:bfd7283f-d46a-43e8-92fd-596aa960fb64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7992","original_object":"UniProtKB:P15391"}
{"id":"cc932459-507b-4c11-bb1e-17ef7bb83440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233291","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:66a2b4d4-fd71-44c8-8fc6-e842f2be4a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2111","original_object":"UniProtKB:P21452"}
{"id":"4d87ef47-6d21-4931-b58d-b64ee46e2b97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190326","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:f68ae38f-dab0-494c-b080-3d0b1a901614","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:731","original_object":"UniProtKB:P23416"}
{"id":"8204b646-a67c-4801-ac48-9c05bbddb47e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1546","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:8dbbcbab-0d13-4d1d-beaf-22a402456ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1546","original_object":"UniProtKB:P49146"}
{"id":"312ef24d-5254-459e-8054-20d961548bd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232494","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:9f8b1f58-2907-4437-a215-311909d0e180","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4232","original_object":"UniProtKB:Q13507"}
{"id":"3d098907-6c8f-4049-be84-65481fc359e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132983","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:faa07d35-dd89-4ea2-8dc0-16c68e1a42ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5848","original_object":"UniProtKB:Q9NQS5"}
{"id":"ca4c2700-fc28-4ada-83dd-7eb905f1d4de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6297","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:8bf00544-c679-4037-b5dd-90be4c15f59a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6297","original_object":"UniProtKB:O75762"}
{"id":"55fcc4ba-ac94-4fcd-8aff-ad464bcf8f3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231594","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:b4a6a22b-f80e-4acd-819b-367b96cd7574","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2881","original_object":"UniProtKB:P06401"}
{"id":"d4a1bb3d-3cb4-438b-a21c-e0fd88a2a8c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:1aad0775-8877-43a1-bf6c-f280add1e6d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P14416"}
{"id":"66533dff-76dd-41d4-8da2-50b702a5b32e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:91f283ca-161e-4fc2-9895-9015fdfc2eb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30938"}
{"id":"477f688f-b5cf-4542-a522-1f6d50a7a7d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10587912","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:2723c790-dcf8-4163-850b-c9282f5c079e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:545","original_object":"UniProtKB:P08588"}
{"id":"f710c696-c8d6-4567-bebd-ae63a5da2491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15864","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:fb531c3a-142f-420b-95a9-78140853e8c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5215","original_object":"UniProtKB:P59534"}
{"id":"1a0afdc8-3809-49e1-84ff-3761d98b6b23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DL772G3NN7","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:6c3a7085-0493-4e31-b20c-db52b40325d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13213","original_object":"UniProtKB:P07947"}
{"id":"f14d3ab6-dc3d-4df5-95ed-1fc5c25af39c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311148","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:6ed1aaef-439d-4b8b-bd5f-e40dd3aa2e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:865","original_object":"UniProtKB:P32238"}
{"id":"f63ff0c4-3d5e-43d0-9a33-56bc478ae328","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25099817","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:305762a0-4e3d-4de3-99f7-f0b209064978","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9112","original_object":"UniProtKB:P59537"}
{"id":"614b699e-a471-4f66-a8eb-cc016dd5feec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24893978","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:3b5945ba-8967-4cc0-aa9c-1fd3fe7541cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8872","original_object":"UniProtKB:Q9UKP6"}
{"id":"e6c04d96-bf60-4a8e-bfb8-836dae8956df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FI3KTC550","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:d958a52b-73d8-4a7c-ad2b-59d1fbf2517d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4327","original_object":"UniProtKB:P14867"}
{"id":"a7b3466d-d02d-49f0-8816-c598f85d372e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36795","predicate":"biolink:affects","object":"NCBIGene:79882","sources":[{"id":"urn:uuid:84ab2ac3-cd3e-47ae-93dd-e46b0c188727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:202","original_object":"UniProtKB:Q6PJT7"}
{"id":"2e750475-dccd-4204-8d45-bfa665cfd966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95170","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:49ca7b51-f24c-400c-866b-8cc271143bce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:366","original_object":"UniProtKB:P20309"}
{"id":"c16d09aa-3c46-4d5c-9e46-d5b3c1d0304f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:bf58a0cd-a1d9-4f3a-878c-305854932c5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P28222"}
{"id":"a2b59949-f699-4119-8cc6-5eb5a9815c4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:8444","sources":[{"id":"urn:uuid:28fc1c29-7659-457c-8c09-e1216832876c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:O43781"}
{"id":"209400d7-3c1d-498b-b0df-db154bdb30f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13302","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:65900d35-09e2-4838-9861-e7002098ddb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13302","original_object":"UniProtKB:Q12866"}
{"id":"c40b3c6d-f810-4317-9baf-14651c5c5c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817398","predicate":"biolink:affects","object":"NCBIGene:24953","sources":[{"id":"urn:uuid:7b105ac1-a889-4bbe-811f-c4d3aff2ee73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1146","original_object":"UniProtKB:P30082"}
{"id":"1e80e682-ea64-4905-8019-2be780bf74e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:ae64347b-24d4-4522-b16d-adfcd27efc5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P00533"}
{"id":"46a65cd6-13d3-4ca8-a141-a8d1561a7d72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34898","predicate":"biolink:affects","object":"NCBIGene:24088","sources":[{"id":"urn:uuid:ff6da1fd-73c5-4b66-8674-3881fd698623","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9024","original_object":"UniProtKB:Q9QUN7"}
{"id":"2b175c72-6662-4a46-86d1-6fe44f178e65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72551298","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:27e369e1-82ca-47fc-896b-c2a368de0b12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6394","original_object":"UniProtKB:P31424"}
{"id":"b6e48b76-cb8b-4ffc-962b-364e14cecd0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1792197","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:b619b591-922a-469c-993a-3dce7c465c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5563","original_object":"UniProtKB:Q9Y2T6"}
{"id":"238e5571-7c0e-4e79-81c7-e5a41697570f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6896","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:cc3b7961-ffc9-4a82-891b-8eb39c07c3a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1233","original_object":"UniProtKB:P25102"}
{"id":"abb9009b-5e85-4715-b6e0-c87ccf0b7bd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118797287","predicate":"biolink:affects","object":"NCBIGene:587","sources":[{"id":"urn:uuid:a1bbe50a-ac1b-4f1e-95c4-6aad6f07d344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9084","original_object":"UniProtKB:O15382"}
{"id":"6bc19e4f-b753-4031-9204-4155ef25ce07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:12093170","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:f0429b15-797b-43ee-8934-28da90ee1041","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9431","original_object":"UniProtKB:P41597"}
{"id":"066d75ea-2820-466d-b07b-c7e38b7f5aa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24754886","predicate":"biolink:affects","object":"NCBIGene:330","sources":[{"id":"urn:uuid:0f41773d-c1c6-431b-a49f-2398cccd3bf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8855","original_object":"UniProtKB:Q13489"}
{"id":"6bbbe871-d6e8-4f7b-a496-9fec6fd5951c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZFY1ZBQ8AV","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:2be4dac1-7a3a-4c47-9e07-c57c6b9193a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12955","original_object":"UniProtKB:P35372"}
{"id":"6ac0fecb-44d3-4953-a1b0-647cd82a666f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A5595LHJ2L","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:c71ba1c3-00f8-44cc-86b7-cd6752676f20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12644","original_object":"UniProtKB:Q9UQD0"}
{"id":"79672471-77b3-4606-8f55-db13b2ad6f4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73380","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:2aa925a9-981a-4dbc-a2a0-a32c7b89f7a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:247","original_object":"UniProtKB:P97288"}
{"id":"8d415ee4-6be5-480a-94ee-ab1b5cdf3b7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:99GS5XTB51","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:20b12797-9d9a-47a6-9a59-05373e76b8ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9696","original_object":"UniProtKB:P52333"}
{"id":"441a24c8-db2f-4c83-9709-d9f81bd37bba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10904818","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:388ce8f4-8b53-477d-be5b-518723cff53d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2937","original_object":"UniProtKB:P21453"}
{"id":"9e51268c-cf08-4ab1-b8af-7ebd4c6fbbb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4046493","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:a6e698aa-8f8c-44a0-89aa-5cd068e147b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3280","original_object":"UniProtKB:P25099"}
{"id":"875e509a-4ad1-4968-9373-4dc737232bfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167014213","predicate":"biolink:affects","object":"NCBIGene:8876","sources":[{"id":"urn:uuid:c592507f-471b-41c1-84d8-1d30c0b695a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13745","original_object":"UniProtKB:O95497"}
{"id":"19a09708-e03e-480f-8c90-9217f2ba3588","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6887","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:b1def1dd-53bd-4197-a77b-cc4590aa62aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7236","original_object":"UniProtKB:Q01959"}
{"id":"44591b08-eb6a-4539-be2c-60d1f3c95294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:eb907b50-0b5a-4650-a3f7-c1f71511556e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P30939"}
{"id":"7e120796-c380-4ff4-afd3-d6bdcc3e4db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11247965","predicate":"biolink:affects","object":"NCBIGene:6573","sources":[{"id":"urn:uuid:ac3a0bee-80a3-4cc8-bdd2-22982fc8ae7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8890","original_object":"UniProtKB:P41440"}
{"id":"8390d521-36f1-4a67-a0eb-e73e26ceb181","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182364","predicate":"biolink:affects","object":"NCBIGene:91","sources":[{"id":"urn:uuid:81da95a2-6847-473b-8b71-6a997608c746","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8144","original_object":"UniProtKB:P36896"}
{"id":"0f405040-3c57-49a7-9476-92d43416b2be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NIL6PST6V7","predicate":"biolink:affects","object":"NCBIGene:1592","sources":[{"id":"urn:uuid:b5641266-e6f3-45c2-8a38-a8f681a17c86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11380","original_object":"UniProtKB:O43174"}
{"id":"daf09b5b-32a3-4a46-8a0e-2f1fec133404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36211","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:d9417c7f-a34b-4e37-b90e-7389bb00a28b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5849","original_object":"UniProtKB:Q9NQS5"}
{"id":"0f5f680d-f137-434e-a1e1-bdc5d26a209c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27999","predicate":"biolink:affects","object":"NCBIGene:16514","sources":[{"id":"urn:uuid:2a3607d6-28d1-4ced-a91d-294bac1400c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6848","original_object":"UniProtKB:Q61743"}
{"id":"e34099fd-5582-42c4-a813-ed911a14130a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:3988c351-eb3a-4ce3-88c2-a07bb1d7b8de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:O94759"}
{"id":"dfee7531-5255-4753-be52-5354b076f788","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433302","predicate":"biolink:affects","object":"NCBIGene:8313","sources":[{"id":"urn:uuid:4f3fb1a4-c578-4425-af77-1cf99b1f723d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12791","original_object":"UniProtKB:Q9Y2T1"}
{"id":"e93b523b-8e52-4de7-bfad-b8cb1cd9df7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:7147b38a-e694-4a32-87a5-bb123f16f047","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P48167"}
{"id":"1310f68e-c13d-4a2f-af06-91054fb3c770","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:b20f87ce-80b2-43d7-bfe4-e490ee6692e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:Q14833"}
{"id":"ac12b445-59e2-4a71-9685-d65d865103fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926514","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:f2852d09-d482-4bfe-82b4-82875c939056","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8162","original_object":"UniProtKB:Q13627"}
{"id":"270f1750-d197-4732-9787-ab855d7fe682","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:4fca7c02-e4d3-4ec1-a450-01a83d83ffc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q9NY46"}
{"id":"578cdfd3-d8da-4082-96ac-af1ca1490e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5649","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:e233bd13-0e0f-44b5-9a5d-939013f1a26b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5649","original_object":"UniProtKB:P30874"}
{"id":"ffe8344d-eec2-4ef9-b137-a8e75d6a60d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2546","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:b0b75c71-72c1-4c6f-8178-6960dd728667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2546","original_object":"UniProtKB:Q12791"}
{"id":"41ef3156-cfd6-42c9-8b5b-bfa38fe29eaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:a088af01-1b90-4688-afae-36244fc5602c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P07949"}
{"id":"f48aa1ba-a44e-406e-8ab9-a9435d01fa02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:273887e6-7c73-4fc4-8be0-b43e3da1ca8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P28221"}
{"id":"13d1219a-7c24-4dff-9a11-0a7fec55b586","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10682","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:ee1f22b5-99b9-4dcc-866a-349173c80152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10682","original_object":"UniProtKB:P14902"}
{"id":"8f5c0b80-3a18-45fc-bf22-885258abd0d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FC5AAH89R5","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:b8f4245a-8d3a-44fb-9c28-b632f3b5bf02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6920","original_object":"UniProtKB:P00915"}
{"id":"dfe42643-c767-493d-bfb3-f29b1d70527a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827346","predicate":"biolink:affects","object":"NCBIGene:11540","sources":[{"id":"urn:uuid:024b2a67-24ce-4a72-9601-b92a573e9534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5622","original_object":"UniProtKB:Q60613"}
{"id":"5c759a17-ec5e-40f4-a2e6-504421baa848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176958","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:b33dbb6d-66be-4bf1-9dd0-86fbd9594fb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1609","original_object":"UniProtKB:P35372"}
{"id":"b56fc82b-d865-4b1a-9e2e-32f66738b01f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145766632","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:8b19dfd0-9d27-4ce0-a5d2-94c8699fe693","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13731","original_object":"UniProtKB:Q13535"}
{"id":"8655cdca-b740-4505-ba93-dd09696bb5ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231398","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:390c1722-b99d-4178-996a-4cb1368480c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9121","original_object":"UniProtKB:O43613"}
{"id":"fcf3de15-a4dc-4aa6-92a2-4844d990fce2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149582","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:e3e10028-6be6-40b6-81f7-219478bc3b4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1053","original_object":"UniProtKB:O14842"}
{"id":"8ea5712d-4633-45d1-8703-a58389675c36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2612","predicate":"biolink:affects","object":"NCBIGene:170739","sources":[{"id":"urn:uuid:9f793369-9b1b-47f5-9634-16003704fe5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2612","original_object":"UniProtKB:O54852"}
{"id":"ea37a85e-9ccb-4d85-abc7-9d5035111183","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44237094","predicate":"biolink:affects","object":"NCBIGene:1195","sources":[{"id":"urn:uuid:097f344a-dcde-43e0-9516-6c5d12c853e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8055","original_object":"UniProtKB:P49759"}
{"id":"e4b19153-ea4c-4912-8a61-f4b86d21df75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11082054","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:edda6e3a-483e-4e4d-b9a5-f3a4d7c234c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3085","original_object":"UniProtKB:P37268"}
{"id":"ecbf9415-ea02-4315-bd53-88b878679c3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:9756da0c-b64d-4fc7-844d-a4213b052781","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P28223"}
{"id":"35abbaba-7a3a-4a1c-b973-9c78ffb77c73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2264067","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:a2fbe279-4bce-45b3-9678-8bab6ca021b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10038","original_object":"UniProtKB:Q8TD43"}
{"id":"693d889b-126b-4cfd-9015-6d97388a7d8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:17ff8fb9-b379-4e84-bd60-185c509cfbbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P06239"}
{"id":"c6e3fbe0-56e3-45d1-90b9-53e819d59659","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449744","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:798fe7fb-33fa-40b5-b563-cd8162f0cb44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:500","original_object":"UniProtKB:P25100"}
{"id":"5072e8af-8550-468e-bb32-d66f6678bc27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311192","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:554d4ba0-9946-4e70-a654-59b9d7e2644e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3887","original_object":"UniProtKB:P24530"}
{"id":"d0d0819b-4cf1-49ce-a718-c50035ad1bef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2221","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:0b362f44-cd3e-47cb-8358-4a59fecfb7e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2221","original_object":"UniProtKB:P37288"}
{"id":"b6431535-2768-4b0a-b3fb-f87a42bfab4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11419","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:8dc7b92d-1ca4-4283-9be2-6941ff79f6ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11419","original_object":"UniProtKB:O43603"}
{"id":"f14bff4e-a180-4666-a6a6-e6b79b71406f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118984394","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:529a858a-ab81-4a22-af0e-636a8376d9fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:685","original_object":"UniProtKB:P30988"}
{"id":"58f27b38-70cc-4b15-920a-1e23f559b22a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8113","predicate":"biolink:affects","object":"NCBIGene:6526","sources":[{"id":"urn:uuid:268c4b79-fe7c-4c84-8c11-be85c2aa9744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4757","original_object":"UniProtKB:P53794"}
{"id":"0ee0230b-4924-4c1d-820d-61af9ce9b4cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:225865","sources":[{"id":"urn:uuid:346871c3-0fd4-41fc-ad71-9da896fb45d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q91ZR5"}
{"id":"8724ff47-896d-49dc-9c44-93a87b3b2861","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:10746","sources":[{"id":"urn:uuid:b23bbdc7-e539-4ee9-a58c-25ebce5495bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:Q9Y2U5"}
{"id":"8e0e1f4e-f5e0-4e8f-a404-c49c3daf3617","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86YZ7HCC8V","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:24954fce-0198-4e7c-b944-c4d8a365ee41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9432","original_object":"UniProtKB:P29597"}
{"id":"1f0e95a8-138b-4cd4-8539-ec2f0440f638","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25175634","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:40c3e01e-8322-471e-a4b2-c0c23c389df4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5457","original_object":"UniProtKB:Q96RJ0"}
{"id":"f0f90bd9-7af4-4b9d-96bf-7122a7936e07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19J3781LPM","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:04fcc1dc-6e5b-4f0c-83f5-259d17a2154f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8364","original_object":"UniProtKB:P23458"}
{"id":"0faaba2d-46d1-437f-84e2-374f0510f02e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75092","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:f0698c1a-b432-4d70-96c4-1dd05ce33c5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:411","original_object":"UniProtKB:P25099"}
{"id":"6c41be45-11b6-4b87-b66d-69b955b96c27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030519","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:864e69b9-d26a-4b54-8a63-de343430bdd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10424","original_object":"UniProtKB:O75116"}
{"id":"75b31a89-8e82-42e3-a718-2c2724896c89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28411","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:30d349aa-e104-441f-9fa4-eea55cfeb187","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2419","original_object":"UniProtKB:O75762"}
{"id":"1058f160-1c0f-489b-b166-abacaa60252f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1309","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:4bb4339b-24d8-4f51-a85f-8301e301e7a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1309","original_object":"UniProtKB:Q99705"}
{"id":"015b5e5e-43af-46ad-a0cc-094d38aae466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50693","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:628dcc1d-1ac6-4262-bc75-33b296f52a95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5225","original_object":"UniProtKB:O76074"}
{"id":"88bf54ce-27d6-48d3-a2a1-283a29c0e332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15118529","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:99fef7b1-59ca-4aa2-afe0-e98cb138dad6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:340","original_object":"UniProtKB:P11229"}
{"id":"607795ef-1b0f-44d0-a945-9b1dffa97390","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37994","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:a4ecf781-822f-42c2-977d-e0accd3d5808","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8482","original_object":"UniProtKB:Q7RTT9"}
{"id":"df8e47c9-4ffa-432d-9d0c-a192195df134","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44222958","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:48734ef6-c16d-48b9-8a89-bd06c3b52332","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8214","original_object":"UniProtKB:Q86V86"}
{"id":"2a1276b6-014d-4e08-aaf2-75dd77ae1263","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93509","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:6fa592ef-61a1-495d-a866-4a75c3a655db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13128","original_object":"UniProtKB:P08913"}
{"id":"82d05b89-72c1-42d3-ba19-45e5c06c9042","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5329829","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:5db5433c-9681-4a88-a821-ccb59e274966","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9513","original_object":"UniProtKB:P35968"}
{"id":"316b8ec5-80a9-41c5-b83f-569ddc5ac6c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7773","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:50b8a88b-6858-4d8f-8338-6fa310ca0030","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2290","original_object":"UniProtKB:P46098"}
{"id":"926d6059-fd36-45c5-9b09-8b332c97e4f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67254","predicate":"biolink:affects","object":"NCBIGene:3276","sources":[{"id":"urn:uuid:5e82ddd5-c603-4b0f-b79e-c146f0fa7d81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7028","original_object":"UniProtKB:Q99873"}
{"id":"3fd053af-f4ec-4129-a789-28f2d57f00b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54613583","predicate":"biolink:affects","object":"NCBIGene:5585","sources":[{"id":"urn:uuid:90b7e695-4826-4fb6-9b85-9ddd7240fe6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8156","original_object":"UniProtKB:Q16512"}
{"id":"f7ee2065-65c4-4d31-8173-f799efec9b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155033943","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:f36ad9df-8204-43c1-9fe7-39daabbcff25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12885","original_object":"UniProtKB:P09874"}
{"id":"dd2d8457-a77f-4e92-88cf-726e22f12f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X46FC5N190","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:00ad27a9-d80f-487e-b8fb-b887be9a1704","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4209","original_object":"UniProtKB:P48058"}
{"id":"553e81da-3927-4078-b7e6-2f712d213b08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69477","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:55e927e2-f209-4888-9c1b-b841893e30d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11094","original_object":"UniProtKB:Q15858"}
{"id":"e1004725-7b62-4e34-a7b2-db5bf678b7bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3960826","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:a2041c62-b919-4f59-bb42-49e302d55006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6496","original_object":"UniProtKB:P51575"}
{"id":"175293cd-4d90-4a43-8b9b-d74bc5984b0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1094","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:3ca619ea-322f-4c1f-8bd0-8d41a8ae67a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1094","original_object":"UniProtKB:Q92847"}
{"id":"f3aebb7c-5ced-4ce9-b3eb-75477fefd859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N5O33BF03F","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:d42233cd-1386-423b-aef6-3bc023266e92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11838","original_object":"UniProtKB:P35414"}
{"id":"5ae91d0c-c05f-4f2c-9baa-7848f5337ec0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15A52GPT8T","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:31268a2d-52b5-48c9-ab94-6b739dfc74a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7423","original_object":"UniProtKB:P08069"}
{"id":"14451b1e-c9a9-429b-8c29-20d8339f3b51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58431184","predicate":"biolink:affects","object":"NCBIGene:3683","sources":[{"id":"urn:uuid:27bf3b7a-a4cf-4b3f-8ef7-b44027db09d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9719","original_object":"UniProtKB:P20701"}
{"id":"df641811-2e6e-4373-8e2e-ca089f7c019b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167671","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:ed78b903-40ff-47f5-89ea-4f3fc5a40bbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10641","original_object":"UniProtKB:Q9NRA0"}
{"id":"6ab61f37-2e80-4d0d-adb1-f8b9863c7ae2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66552906","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:1d98925f-02a5-4922-9129-f2c686f11fcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9500","original_object":"UniProtKB:Q9H1C0"}
{"id":"b4c1f5ee-ebe5-4b78-8861-16aef4a7b2da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926514","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:b6dca36c-b92f-4a33-b24b-73d48d14918c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8162","original_object":"UniProtKB:P49760"}
{"id":"67477f7e-ea7d-4a36-a0e5-bb5d670a0054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2563","predicate":"biolink:affects","object":"NCBIGene:24520","sources":[{"id":"urn:uuid:65c59b61-df6d-4985-a92e-25d716a40a2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2563","original_object":"UniProtKB:P10499"}
{"id":"ab58711f-be98-4d02-99d8-4e8293037735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41948","predicate":"biolink:affects","object":"NCBIGene:4953","sources":[{"id":"urn:uuid:3011ce2f-843d-4201-be6a-a991b3521c46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5176","original_object":"UniProtKB:P11926"}
{"id":"9f7894e1-0dec-408d-a694-e2eb08699d09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803080","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:1dee9b68-ebe0-4487-838a-24132467cb0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8753","original_object":"UniProtKB:P24557"}
{"id":"88e2bb23-3a0d-4dc7-96e6-bb2fc8c92280","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996518","predicate":"biolink:affects","object":"NCBIGene:11202","sources":[{"id":"urn:uuid:54012abb-1ec1-460e-a8cf-d86e6a32ecbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10576","original_object":"UniProtKB:O60259"}
{"id":"612ac21f-01f4-4e89-b163-cdd2347a9fc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17858","predicate":"biolink:affects","object":"NCBIGene:2936","sources":[{"id":"urn:uuid:09581976-131a-444e-aab9-c26ea60db733","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6835","original_object":"UniProtKB:P00390"}
{"id":"74b6c5e3-d03d-46ac-a90d-c7e3f266e850","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321156","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:604a5e6a-0ac4-4218-be13-1743d3d30e2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10148","original_object":"UniProtKB:P52333"}
{"id":"d79590ee-37a2-4c04-9957-76c9968d7899","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:ebc6710f-8ec1-4a3b-beca-f72ffbb97154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P50406"}
{"id":"e92acde7-c718-48dd-81ae-15a6df44a966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:7c73ada6-93c8-46a8-9941-522c78b83315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P28222"}
{"id":"ffe170ae-2f04-417c-b32c-74b61ad3404b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:55285412","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:95d99833-a494-4fa8-ab1b-e85a2746e8cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4143","original_object":"UniProtKB:A8MPY1"}
{"id":"60be24c9-5d3d-46f3-a836-eb0a24bcd68e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95086","predicate":"biolink:affects","object":"NCBIGene:84456","sources":[{"id":"urn:uuid:95e00a02-cc38-4452-b0bd-2a3c7e71d723","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8232","original_object":"UniProtKB:Q96JM7"}
{"id":"bd7be924-2258-46cb-a6f3-a4e12b00b729","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072559","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:aa6e059f-db2a-409d-9843-80da4f8c4254","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9009","original_object":"UniProtKB:Q9GZQ4"}
{"id":"5e00a8ed-b5be-43a2-bcc5-fa30cd599315","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:670","predicate":"biolink:affects","object":"NCBIGene:25245","sources":[{"id":"urn:uuid:7385f87a-2b6b-4fc1-97de-26346784cce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:670","original_object":"UniProtKB:P25023"}
{"id":"45c4b6d3-f32a-4e36-b367-eeeed3e1ce23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25088319","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:687f1074-0185-4473-9d02-99a1e7719bf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2128","original_object":"UniProtKB:P29371"}
{"id":"81069fa8-dcf2-49a1-8266-58033ab5ecc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73224","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:805fb268-f3f8-4478-958c-6ee3661a3316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2420","original_object":"UniProtKB:O75762"}
{"id":"979c94c6-609f-4feb-b22a-202b368bf8f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:fc41936d-457a-433d-bcc5-fc373ee4d0c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:Q06187"}
{"id":"2ba97252-ea83-4e50-b235-83f27800978f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45409","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:d80ac292-b464-410e-be00-0b8cd1bb2ee7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8804","original_object":"UniProtKB:Q9NYV8"}
{"id":"3ac16e02-3e4e-4006-bd86-561d2f37ed26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15765","predicate":"biolink:affects","object":"NCBIGene:4935","sources":[{"id":"urn:uuid:29f3cff7-282f-4db5-8aca-b8bfe1914927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3639","original_object":"UniProtKB:P51810"}
{"id":"223db35b-4015-4d4c-8bd5-58c73a069eae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12361","predicate":"biolink:affects","object":"NCBIGene:84868","sources":[{"id":"urn:uuid:dcfbe477-7ba7-4ab6-828b-06e9387c0261","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12361","original_object":"UniProtKB:Q8TDQ0"}
{"id":"cca46488-2349-4a85-9dd0-0b804e46f5f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71940","predicate":"biolink:affects","object":"NCBIGene:50940","sources":[{"id":"urn:uuid:4fa3cc98-9ffa-4dab-ba42-05c4b3cb9c6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7299","original_object":"UniProtKB:Q9HCR9"}
{"id":"8637c1cc-923a-49ac-b91f-cfc7b7b7c2f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5068295","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:11512e9c-e4e8-42ef-8a94-d4da694676f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4295","original_object":"UniProtKB:Q9HBA0"}
{"id":"8708cb6f-aa24-405f-9565-88ce6ad02d88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17295","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:f5a18017-08f6-4afa-904d-9a195f0279e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3313","original_object":"UniProtKB:Q6DWJ6"}
{"id":"320296bb-f773-4315-a7b4-404d2b687eb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104162","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:f6e838d2-a779-4485-bad0-aa2613c39123","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10104","original_object":"UniProtKB:P11229"}
{"id":"2ee53145-13c9-4c40-8e25-41d09a857bcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817407","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:60aaf9e6-87b1-4e6c-b167-82d5d7737150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1459","original_object":"UniProtKB:O43193"}
{"id":"db9675b7-7370-4642-ad98-2f32e1ff075e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38322","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:a34d2579-fcaf-44e0-be3b-0484e1fd6386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:303","original_object":"UniProtKB:P08173"}
{"id":"fbd079be-4783-42b5-b511-1cd926ec6d4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2233","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:6100155f-b254-4bdd-96c5-aa1a35db35f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2233","original_object":"UniProtKB:Q00788"}
{"id":"045584c9-afec-4fba-9655-8deb36727a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2525","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:2f19f687-0e99-463c-94eb-c9755dd1a7f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2525","original_object":"UniProtKB:Q13936"}
{"id":"9e76345c-9245-49f5-a3a8-c6c2cb8c0238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:a1f99a1f-4b68-4b20-994d-061c4248f672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P30994"}
{"id":"fca1024e-4c12-4f91-936a-99a685661793","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31231","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:47564c70-37e4-41ee-a3a3-2ef67c6c0d52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4261","original_object":"UniProtKB:Q8NER1"}
{"id":"c8d01107-602c-4210-9e6f-b2bd08371a20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:f7b3a41d-724c-4455-82cb-5a3ea3715905","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P08908"}
{"id":"b1bf3416-a656-41cd-8886-e5e7448694b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553171","predicate":"biolink:affects","object":"NCBIGene:8322","sources":[{"id":"urn:uuid:13e88dad-7904-46a8-b262-9cb51fce291f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10321","original_object":"UniProtKB:Q9ULV1"}
{"id":"0f389a5c-b71c-49ce-87d9-ad65eeb66ca9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F1516R3E77","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:03ef67d4-1b98-47c0-8e0f-e07cd0721aaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10462","original_object":"UniProtKB:P25103"}
{"id":"92122319-ac8a-48b0-8487-57b873aceac8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195326","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:ba465868-f216-4b18-939c-68584de3af19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1323","original_object":"UniProtKB:P41968"}
{"id":"194fede7-b059-4b8d-bd79-b9c43c2f13e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154617563","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:dcca5241-4979-4268-9c47-48568ee43e79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13513","original_object":"UniProtKB:O43614"}
{"id":"c4cfa54e-255e-4e30-bd3c-aa9cc0d8875d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69586250","predicate":"biolink:affects","object":"NCBIGene:2170","sources":[{"id":"urn:uuid:ffe14dcc-5203-46e9-9280-63456dd380c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8797","original_object":"UniProtKB:P05413"}
{"id":"79086d03-84da-401a-ac05-3d53e4102de5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1104","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:d3b44488-b29d-4238-b6f9-769369b38c62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1104","original_object":"UniProtKB:Q02644"}
{"id":"b91ee966-283a-4250-ad3c-b62b87cca468","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5130","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:0bc54315-a156-47c6-afa6-9029a5217e90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4194","original_object":"UniProtKB:P35354"}
{"id":"d4d424cf-0066-40d5-b959-2b448964fbde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11837221","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:a37df6eb-7ad0-4145-b97c-6e5230e95dda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9318","original_object":"UniProtKB:O15554"}
{"id":"ed3bb26d-a236-4f70-99b3-50ab4fac4bf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127043376","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:82ba6f06-145f-4c1a-a4dc-d1ddd647f60d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8526","original_object":"UniProtKB:P35414"}
{"id":"1268869f-cf79-4655-9caa-7921d2bf506b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"NCBIGene:778","sources":[{"id":"urn:uuid:60eb52f9-7aaa-4442-b156-8fa010ea8e7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:O60840"}
{"id":"aac9b976-2138-4519-b530-f6560f37c5fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44828492","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:78577e9a-eb2d-4668-8d00-f127975a9865","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7851","original_object":"UniProtKB:P21554"}
{"id":"b8f776ad-602d-405e-bdea-a64da420dc41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:cc881848-86fa-480e-ac1e-eefb3026475d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P14867"}
{"id":"6c0d7dbf-b684-4424-be6d-959472766b36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7476","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:30645cfa-d8a4-4694-99a7-7dcab28344b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5230","original_object":"UniProtKB:P35354"}
{"id":"c5178b3f-5fec-4a8c-af96-e0fc5ed306af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I60W9520VV","predicate":"biolink:affects","object":"NCBIGene:112398","sources":[{"id":"urn:uuid:61e29bc6-6a0f-4a26-ae62-184fe2141143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11831","original_object":"UniProtKB:Q96KS0"}
{"id":"05ae158e-6c45-4044-a8e9-0001a0015cd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182364","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:31e541a0-192d-453f-a72c-b1c0ab793dfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8144","original_object":"UniProtKB:Q04771"}
{"id":"fb0d386d-21e4-4f39-90b3-fa17f14dc7c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2427","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:18db158d-ef6f-443b-97ec-1dcc2f4e002c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5939","original_object":"UniProtKB:P00533"}
{"id":"0f933b85-36d2-49a9-84f5-c6160c1eab9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229230","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:2413764f-33a7-49d2-8709-989aacdb7c24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9331","original_object":"UniProtKB:Q9H228"}
{"id":"cdb60ccf-ef9a-41f0-aa76-2af295d31cc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1529","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:04be876d-beb9-4882-8a47-2118063b3e30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1529","original_object":"UniProtKB:P21555"}
{"id":"04cb1136-61d7-448f-8bdd-0e2ab38e44b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754993","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:e2c745fe-9d29-4194-b729-37548a308b2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:436","original_object":"UniProtKB:P0DMS8"}
{"id":"a3c313d6-db19-4af9-b313-fa16c352903d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177616","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:78a38b5e-dd8f-4631-8066-a680b06dcabd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2488","original_object":"UniProtKB:O35433"}
{"id":"b019b641-f10c-4b03-a998-a560a70818ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91399","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:818814ae-dad8-4b97-bc68-76ee258ff26d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5670","original_object":"UniProtKB:P50750"}
{"id":"65f67d05-5d49-4a40-b791-48f4b35c1933","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:9344","sources":[{"id":"urn:uuid:10aa5c9a-2e13-49ee-9700-a901953e17ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q9UL54"}
{"id":"33b3f03c-b8a1-405e-9096-2c9a2a449c70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821498","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d2c2cf66-9d7b-481a-9cdd-4f58a7c2e1bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:167","original_object":"UniProtKB:P08908"}
{"id":"59035264-1991-4071-8f62-e5a2f46f1a7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679541","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:e418150a-4697-4276-acc6-60f0a985ca60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11861","original_object":"UniProtKB:Q9GZU1"}
{"id":"96e3b1c8-4ec0-4087-8480-10800c609f62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437356","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:d357f23e-7ee9-4c3a-a67b-ebd0381541a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4170","original_object":"UniProtKB:Q14957"}
{"id":"c1036668-d7a7-4c61-a1ce-c9940d0f21c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080871","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:99fb4a1b-01d9-4215-9565-8ce158c37f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2179","original_object":"UniProtKB:P30559"}
{"id":"7d4f704d-fc11-441d-b2dd-1e8c06508062","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44343301","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:3a5f56ba-49a0-4683-b202-c7db4963f497","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8613","original_object":"UniProtKB:P43235"}
{"id":"08e3b409-7568-466f-befd-30c9b5d11b54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2040","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:abca9bc4-814a-4f2b-8b3b-1f9ab19dd271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2040","original_object":"UniProtKB:P30936"}
{"id":"3854b501-c6a9-4cf0-8f85-66b842e2a85e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321930","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:fb80adf8-dbfa-40ad-8891-c058ff009d71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6512","original_object":"UniProtKB:P30531"}
{"id":"f9dfa5e0-da8e-4eef-afa3-6aef41507e67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64055","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:d2429a86-a379-4f5f-bee1-af1b98b32162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:109","original_object":"UniProtKB:P28221"}
{"id":"56284ce5-4e18-4c23-8d7b-bc067f5fa070","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:7930dad7-7fb8-4499-8aa2-af7a172d9198","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:P56524"}
{"id":"b1e5190d-34ff-4f10-a191-1cd6346d5de9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12494","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:16076117-7259-4950-a2ae-bce193a156a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12494","original_object":"UniProtKB:P30550"}
{"id":"c593287b-6476-47eb-b443-0103b64bec64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:56543","sources":[{"id":"urn:uuid:95cc41f6-9a87-45a1-b30e-d7582cfbe095","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q9Z0V1"}
{"id":"76594be1-2fa9-4144-9531-5018414ac7ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25263088","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:8c098d3b-3ad8-49e2-87b4-c8693a6e6b1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8645","original_object":"UniProtKB:P53350"}
{"id":"45a49722-cb27-4cb2-bdb2-1e83b4619029","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RWL9H93ARB","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:62b0a895-be05-4f47-8920-564d31ef5251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3301","original_object":"UniProtKB:P30729"}
{"id":"af5524da-94c1-4eed-bd05-5c3695fc9690","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1534","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:4f58d078-4b1a-48de-af0a-da3cef5146f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1534","original_object":"UniProtKB:P49146"}
{"id":"501aeb9e-2f3e-4b87-a6e9-382d1ffbaf3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151447433","predicate":"biolink:affects","object":"NCBIGene:23387","sources":[{"id":"urn:uuid:5dd58cee-85e3-417c-aac8-6f1759443a16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13303","original_object":"UniProtKB:Q9Y2K2"}
{"id":"7c932876-aee0-4876-8b22-cd3dfdb4a754","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:b4154be6-af85-4b26-8782-0c2f98be0157","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28223"}
{"id":"606ad081-0b56-45b9-8930-deadbe83ea30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44423","predicate":"biolink:affects","object":"NCBIGene:6240","sources":[{"id":"urn:uuid:699458ca-2d1b-4a1c-b068-b698fbdd026d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6822","original_object":"UniProtKB:P23921"}
{"id":"c2a27a89-0416-4578-8c7f-1fb70fc6d2dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:e02abca3-6e1f-4a7b-9c73-4d598c80d10a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P70597"}
{"id":"b082aee7-f287-4e07-a5e5-4354bcbc6e66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817427","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:9014dbd4-746e-4bdc-82c8-4096ac0148cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1788","original_object":"UniProtKB:P70555"}
{"id":"95b4892e-d679-4da2-a1c2-6fbda36dfeb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:05c8032b-f314-4c7f-abdb-9c4ac95e9ce1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:P25021"}
{"id":"7e6d552e-bf2e-4d90-9bf4-a95e08a8e1f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9691","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:910d4ec5-a7b7-40ef-9ed8-575c698f5fdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9691","original_object":"UniProtKB:P07949"}
{"id":"64459209-c70e-4c00-8236-0a69891a0cd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9XW757O13D","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:ae711aa1-6a53-4feb-b176-546a2fc8b751","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9175","original_object":"UniProtKB:P10721"}
{"id":"ec5ff460-952a-4c8a-8f86-9dba5a45dd4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92593","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:4034098e-91d3-4b43-b3da-a198e91f0d2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4346","original_object":"UniProtKB:P47869"}
{"id":"74057447-219a-484c-b394-c84f9264d32b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11501506","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:d2c04da7-7eec-4b72-8762-5a9e95cfbda8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9872","original_object":"UniProtKB:Q9Y5N1"}
{"id":"3573d1a3-56f6-4bc8-af39-09ca4ede7b1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947058","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:1b0e54b1-2f44-40de-8d2f-ceff35496ded","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3124","original_object":"UniProtKB:P37268"}
{"id":"cfc77b9e-79b3-47b9-a726-5a98f1046768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5766D7AFA7","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:8753a09b-7c18-4132-8a52-f7779bdd9097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:732","original_object":"UniProtKB:P20272"}
{"id":"c3d92a5b-b6bd-41be-9dc2-6493a0aa3aa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76609","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:9c5cbb5a-c00c-417a-9571-56dd74bad28c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10070","original_object":"UniProtKB:P24530"}
{"id":"2f7ad64b-c538-4d19-9ff4-b7f31cebf58e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17134","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:cea59d4d-5590-49cd-bb89-7cc2ab447015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2149","original_object":"UniProtKB:Q96RJ0"}
{"id":"b1d7d335-abe5-4751-b292-507a5efaed8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755242","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:0ea49c43-9e9a-4134-abdd-ff4a1cffc368","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6732","original_object":"UniProtKB:P17764"}
{"id":"1395eef4-f330-4ee3-b619-deea6f94a8a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49848557","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:279b1d99-8b9a-4940-8f63-2f9345db003e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9492","original_object":"UniProtKB:O95136"}
{"id":"8a486690-e019-4585-bbf3-41d38221bd5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134558471","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:e3ead553-560a-469d-a815-098f98439a01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12371","original_object":"UniProtKB:Q06187"}
{"id":"a21a65b0-9bcd-4264-8c2b-f3ad86127256","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79995","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:d2f28a81-5aba-436b-bff4-f6d3dd250310","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2754","original_object":"UniProtKB:Q13133"}
{"id":"38fbf835-ee54-4b4d-a852-48db0e25e4c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993635","predicate":"biolink:affects","object":"NCBIGene:23043","sources":[{"id":"urn:uuid:3cde8952-4eca-4697-854f-e0c8e4b47c82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12334","original_object":"UniProtKB:Q9UKE5"}
{"id":"0b3b3a73-f3d5-4242-8f39-f4788b0557a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:219770","sources":[{"id":"urn:uuid:d26c7f8d-5dc9-4b34-938b-0b9d50ae82bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q96KN9"}
{"id":"4ef0f37a-5274-41fb-823e-16c3a592463d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3981","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:c757effa-c805-4502-b9f2-0a96c5e7c1c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3981","original_object":"UniProtKB:P02708"}
{"id":"3859e055-a186-43f7-8a0b-c327d66d0e8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82813","predicate":"biolink:affects","object":"NCBIGene:1259","sources":[{"id":"urn:uuid:ef51ed87-7552-4e59-b1ab-48d842daca0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2349","original_object":"UniProtKB:P29973"}
{"id":"9cd91628-b5d2-49fe-9363-36d5b5650bbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:abaf1bc6-25d6-45fc-80ec-aa9bd846a412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P32241"}
{"id":"4e786e5f-5a58-4e88-b762-d158199090ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5DKZ70636","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:9e157664-6b0b-4609-ac32-5076b72cf3ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10097","original_object":"UniProtKB:P42345"}
{"id":"e2b1036d-efbf-4c93-a44c-7b6a6b5cfb88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53232451","predicate":"biolink:affects","object":"NCBIGene:4593","sources":[{"id":"urn:uuid:ce51f25b-bf4a-4105-9d1f-f4ff845f8489","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8123","original_object":"UniProtKB:O15146"}
{"id":"dcf71fd6-54bf-456b-893e-23a498646990","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229226","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:56388c64-a8ce-4c2a-bed4-cf574ee5f95e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8312","original_object":"UniProtKB:P13866"}
{"id":"f028a6fc-aac4-498a-8a5c-737525243ad7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75107","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:27810f35-2e47-4eb2-9bd6-63203c7e50c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12440","original_object":"UniProtKB:Q9NYV8"}
{"id":"9cbebd09-0981-47c0-8c92-8fd1cfad8043","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:363","sources":[{"id":"urn:uuid:8e56920c-5e3b-4361-b4ca-6e45642f09ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:Q13520"}
{"id":"3d2cae4e-2a88-4424-a029-5a5d5f4a1a0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91351","predicate":"biolink:affects","object":"NCBIGene:9578","sources":[{"id":"urn:uuid:8e0f83d6-4536-482a-8e33-d6f922ac88a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8204","original_object":"UniProtKB:Q9Y5S2"}
{"id":"7e562a83-cd72-4e28-90c7-3bc652f0f037","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63827","predicate":"biolink:affects","object":"UniProtKB:Q00910","sources":[{"id":"urn:uuid:25c4c2f2-1c99-4504-96c2-3771e58dee08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4506","original_object":"UniProtKB:Q00910"}
{"id":"4c21cd6f-24f5-47ac-a168-231aa20a3848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27882","predicate":"biolink:affects","object":"NCBIGene:50832","sources":[{"id":"urn:uuid:6c34e7dd-4c68-4cd0-820f-817a01a0a511","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2367","original_object":"UniProtKB:Q9NYW5"}
{"id":"019ff928-e64b-4835-88f9-ad5fd321fcb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3874","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:8a9f5ec4-49c7-4661-815f-0ca23f1194fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3874","original_object":"UniProtKB:Q9HBX9"}
{"id":"4899dfa9-9eae-4ae6-b930-57080854c939","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15713","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:a338d8ae-232b-47bf-9c9b-601d34e73e50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1734","original_object":"UniProtKB:P51582"}
{"id":"b7f37ef5-bf22-4986-a976-c238f2998a9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92733","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:2317915f-dcdc-453a-93b7-5183dd6bc15a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1703","original_object":"UniProtKB:P56718"}
{"id":"8e92b34b-fe3c-4e61-870a-5da4fd628e6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53630394","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:9d69b3ae-7972-458a-8c47-c77787814422","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5738","original_object":"UniProtKB:Q8TDV5"}
{"id":"4c9f4ab9-bdfa-4ced-8b01-28b89ac1df92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:09051cb0-ce73-4c41-9e3e-b08d6914eb77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P25100"}
{"id":"62678454-eee5-4b8d-835a-771040c6a5b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XY4SZP4C72","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:262eb2b3-80e1-434d-a79d-fbe38fea4df2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4142","original_object":"UniProtKB:Q99572"}
{"id":"f2fb474d-8397-4150-a55e-581c0be2b597","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2950887","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:002bcf98-1820-4db1-bffd-12d571cc4672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12536","original_object":"UniProtKB:Q8TD43"}
{"id":"c16734c8-6f9e-4b38-b097-844a160a116d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10449757","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:a2722af1-0a7e-462c-9fc1-938b4b62b659","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:190","original_object":"UniProtKB:P41595"}
{"id":"e972d010-5d4d-4923-a26a-69da5ff11c98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45265746","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:0ff712b5-f6ac-43df-84d6-0103cd80079d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6725","original_object":"UniProtKB:P17764"}
{"id":"d6af3c39-f791-427b-8e57-9f7d71b5db87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:350f5ac2-8d57-46de-8f77-c381bd6a5271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P31388"}
{"id":"debf56c9-e596-4be3-b1ba-1caf6c364e36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5776","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:4af8cbef-e084-4132-b47b-32df973c8ca2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5776","original_object":"UniProtKB:P21730"}
{"id":"f6b8e907-6392-4495-a9a2-e462655b6377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:1e2c5dd6-e7c7-4aaf-b5e2-06b7267da4d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P14416"}
{"id":"e22c5cb7-1861-4250-8be7-de0e3b117d1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16095384","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:bb73f0ca-e2d3-4b49-946c-308f416918b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4132","original_object":"UniProtKB:Q7Z2W7"}
{"id":"0f119bbf-5613-4972-81d3-a8452db53523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:26b66fb6-4d5d-45d7-aca1-d5ad1fc610d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P35968"}
{"id":"a87b4762-cd98-4c7e-8f6d-b2d853f8d6dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64122","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a0568814-c9aa-4fc7-a6a0-b96a40c0a610","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:960","original_object":"UniProtKB:P14416"}
{"id":"daf6b1ee-1ed7-4696-a0bf-159335b6352c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230832","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:a2554076-a772-4c75-aaa2-da559e2ed960","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12576","original_object":"UniProtKB:P18089"}
{"id":"400a8595-b174-491a-b1b8-d5e1d44e08ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494245","predicate":"biolink:affects","object":"NCBIGene:4193","sources":[{"id":"urn:uuid:57120483-43be-4f00-8485-91e70b70a7f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13126","original_object":"UniProtKB:Q00987"}
{"id":"22af5d03-38e1-4c5c-a5d9-0855d9b93b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90531","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:8196d06e-4f20-4f71-98dc-54fbf7e16e0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7946","original_object":"UniProtKB:P17252"}
{"id":"57397cb4-b903-4a41-8cec-f61569b091bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:721809WQCP","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:3005095c-2a17-465c-a167-60278c413351","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5263","original_object":"UniProtKB:P05129"}
{"id":"0654ed54-77f4-462e-9766-a0cb86dde939","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H32ABL87X4","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:d8e4e2b2-f797-44e7-b5ac-e0205743b94b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2673","original_object":"UniProtKB:Q03181"}
{"id":"5a8c557d-b17a-4c11-919a-73a99f55157d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030535","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:f2de380c-9358-4109-8cff-303f21f3d29b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10489","original_object":"UniProtKB:P42345"}
{"id":"18dd138c-9ca8-4826-a682-60bfab3a0edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:00LOF6890B","predicate":"biolink:affects","object":"NCBIGene:5328","sources":[{"id":"urn:uuid:7d60b7e9-c830-48bc-aca4-6a6d51da4b9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6498","original_object":"UniProtKB:P00749"}
{"id":"0f9fca58-64bd-4080-a3ba-91bc87c0201d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:d3266aed-6282-46c5-a6f3-077590af85a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:Q04771"}
{"id":"0835b6a4-a893-451e-86ab-7e8fdefe82fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439091","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:daf32080-6db8-4810-b35c-b9bac8e0c597","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5606","original_object":"UniProtKB:P0DMS8"}
{"id":"79a19671-156c-4988-8439-270d3c84056a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67461788","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:8a773a42-2641-4150-981a-a39766f2a1e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10503","original_object":"UniProtKB:Q99572"}
{"id":"b24843f8-d71a-4ea4-9cf0-8553673fe64b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311481","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:16430838-dc88-44a7-a20b-61a029240667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1637","original_object":"UniProtKB:P41143"}
{"id":"d02c194d-ad22-4e30-a6c8-a32c141ae345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:d646026d-c7ea-4020-af46-9580c2fe55d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P21918"}
{"id":"d7f0990e-c93e-42ad-8614-f4d30ba727a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:4058","sources":[{"id":"urn:uuid:077863c8-58a5-4a6e-b76f-2f7f1d4865fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:P29376"}
{"id":"ddbfe6fe-e48b-4867-9664-125ce0a2dd55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12349","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:0b11a079-3dea-4ba4-84aa-9d763a918812","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12349","original_object":"UniProtKB:Q15116"}
{"id":"59368d67-9e5d-411f-9e62-5dd496d221ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Z3QHB00LB","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:7f0bb653-0beb-451e-8dce-ea4d6a498b21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8383","original_object":"UniProtKB:P42345"}
{"id":"a5dfe712-bbec-48b0-ba9e-acb5836569e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:87775b71-d565-4b49-aa35-2477832d1966","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P12931"}
{"id":"bd998fde-4d9c-43a7-a067-171168091dc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813889","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:c42155c9-3cc1-4325-a5df-223b42fe9240","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5391","original_object":"UniProtKB:O88854"}
{"id":"53f5d552-5e32-45e5-adfd-4fa82d9c28ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131438","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:eaffa643-b0f1-4734-8e9d-ee7dd726f470","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1047","original_object":"UniProtKB:P25090"}
{"id":"666fccfc-98e1-4049-b183-bdc9e5766f34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3640","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:0803e02d-79b3-4809-83b7-33f69a0020eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3640","original_object":"UniProtKB:Q16581"}
{"id":"70c89936-3377-4cba-9d8b-c49c916fb321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947037","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:73693af0-5fbe-406a-9f76-11500db4ac33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2987","original_object":"UniProtKB:P04035"}
{"id":"c12d8cd5-ca52-4f1f-88fe-af08ce7dad20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:f1149eca-cd69-4c61-89b3-452c80a8ad56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P08485"}
{"id":"4cb700fe-5482-442e-a873-7033bff61be5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030518","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:e73623bd-0ae9-4f3d-91d4-c93cb05e0be7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10420","original_object":"UniProtKB:P07333"}
{"id":"ae14b848-0517-488f-8272-6b080981ba02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13649","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:3d45474f-16cc-448e-9052-e15e039cfab6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13649","original_object":"UniProtKB:P21860"}
{"id":"05d324ae-fb97-4e6d-a376-82ea78ee2975","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:172V4FBZ75","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:22ab8fcf-a0b7-49e0-ad49-414724723e47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4129","original_object":"UniProtKB:Q8NER1"}
{"id":"db806c12-8a5e-4b36-a66b-68285bde28a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:38ce4c95-acd5-4401-b12c-4b3a478972d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P14842"}
{"id":"e21c08a1-d151-4541-88bd-c43406d43326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76318115","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:21683556-49ba-42a9-a29a-186796595626","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8603","original_object":"UniProtKB:P08246"}
{"id":"a825f4cb-241c-4103-bd91-f1264ffda363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124108661","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:7483e20b-5c35-4671-92a6-460c5a6079cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11661","original_object":"UniProtKB:Q9UHD2"}
{"id":"5337824b-68e3-4ad7-b6e6-d00552f68054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66889","predicate":"biolink:affects","object":"NCBIGene:2057","sources":[{"id":"urn:uuid:f21dacf3-ade2-408d-8316-5f3ead5449e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7447","original_object":"UniProtKB:P19235"}
{"id":"81c1bf79-220b-4099-b81e-5e19685e36b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3655","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:0562e5e9-2366-43e2-a2f7-d80df8673ebe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2322","original_object":"UniProtKB:P70604"}
{"id":"dc1d3d4e-1a06-4a74-8bab-1c676ae8f507","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9062","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:9f125465-9549-4825-8ed2-fbeb7037349e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12463","original_object":"UniProtKB:Q7Z2W7"}
{"id":"88cb1280-1314-4338-92bf-3e3f0ba9f55f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6706","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:d819a2c9-45e6-4cd3-ad75-2927c15fbca0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3990","original_object":"UniProtKB:P02708"}
{"id":"2f682429-97fa-4be4-bc4f-3e1b8f79e94a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:73I34XW4HD","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:832f68a9-1225-4c3b-8997-682a0828021e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7959","original_object":"UniProtKB:Q16539"}
{"id":"09e771b7-123b-48a8-bbdb-24155a6f1458","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25138295","predicate":"biolink:affects","object":"NCBIGene:5950","sources":[{"id":"urn:uuid:ef37eeec-4b03-490f-9e76-b8a74a392b2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8792","original_object":"UniProtKB:P02753"}
{"id":"ee6aed62-6e28-4893-a15f-fca4a283a802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143992","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:6c62110f-5eb3-4a5e-93c0-a54767975b07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1410","original_object":"UniProtKB:P70579"}
{"id":"ec4a751d-573c-4ad5-9264-e1222c6af32e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15JL80DG6H","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:7e8e7ce7-816b-456e-8f8c-5cbd7b9f79be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10658","original_object":"UniProtKB:Q08345"}
{"id":"3f078850-79c1-4748-81b6-0634260924dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72722131","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:546c5d79-6333-4924-b9b7-ed96d0b1ef8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12521","original_object":"UniProtKB:P43114"}
{"id":"d92b0191-6141-49d5-b331-ced60479f7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121918","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:f1019550-caad-4a27-bc4e-cd70da7f1e74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4086","original_object":"UniProtKB:Q05586"}
{"id":"51509001-838b-4845-b0c9-39c80bee291e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101205709","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:a9314607-81fd-4876-b6fa-3755f0b8d92e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1573","original_object":"UniProtKB:P20789"}
{"id":"e3e9d8b0-d9fd-4dc7-b10e-59aed215423d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51845","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:97451f5b-dc44-44bd-9d3b-ea45836e851b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6293","original_object":"UniProtKB:O75762"}
{"id":"4d28db23-069a-49ed-9dbc-de2a5b7a517c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44349330","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:37446355-f984-4590-be3a-384eeb5062de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2964","original_object":"UniProtKB:P51639"}
{"id":"12803a59-ca71-4856-b1b6-61d3f81cad5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553175","predicate":"biolink:affects","object":"NCBIGene:8644","sources":[{"id":"urn:uuid:43f73fd7-7deb-4bf6-bd28-b27ea4fe434f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10344","original_object":"UniProtKB:P42330"}
{"id":"e800428a-8586-41f6-9e3a-626c5f9d4b31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035449","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:9f6bc656-0813-4147-a0d2-b56ff8264970","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:638","original_object":"UniProtKB:P46663"}
{"id":"b55658fc-bd90-4740-beb0-64e3d879dd5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2788","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:62182c13-a853-4a0d-abc9-44932584ef7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7117","original_object":"UniProtKB:P08913"}
{"id":"768eb5c3-a217-4d01-ac06-2b8444b5b6cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7851","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:089c7f6a-9a00-42b8-9e72-92af9d661fe0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:302","original_object":"UniProtKB:P08172"}
{"id":"b1ed0e92-f451-4f19-9652-51709c304a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:21599115-7b46-4e36-bde2-3bbe2c2cc807","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P12931"}
{"id":"0c53e12b-5be8-4613-90ec-3dc473261fad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131180","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:85483cb8-a833-48d6-8941-a0da46ceb07a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:567","original_object":"UniProtKB:P13945"}
{"id":"e1e937b2-82c1-4597-9900-dcff7af811c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8255","predicate":"biolink:affects","object":"NCBIGene:325","sources":[{"id":"urn:uuid:4678a27b-8a27-4ceb-8fc7-2f9fb31be1ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8255","original_object":"UniProtKB:P02743"}
{"id":"a8a17d7a-78ac-4ece-b8aa-b0aef62083b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519693","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:d9205e28-f4de-4798-b40f-a74320b7922d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8148","original_object":"UniProtKB:Q06187"}
{"id":"b4b6b912-5ec1-4bb0-9173-97831070ef85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437356","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:1509a00a-b492-4337-a058-18bdf50cc729","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4170","original_object":"UniProtKB:Q13224"}
{"id":"2243b2f0-7e16-48d3-87ab-df603ae777d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6220","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:e493a04d-27ea-4180-8ec6-b916f0e0a751","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6220","original_object":"UniProtKB:P31422"}
{"id":"6a33f8ee-7589-4ec1-9dc8-32c6d50f031b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7SE5582Q2P","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:427b92a1-1b1c-4266-b65e-ae21a5ecfb49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9068","original_object":"UniProtKB:P20594"}
{"id":"c528e936-b706-487d-9683-c5df40190207","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KT54N4CC67","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:aadb411c-e735-4596-a2fb-f1a6c86ef84d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:160","original_object":"UniProtKB:P28335"}
{"id":"7798b422-9176-467d-bcce-98cb78bf9e52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:a19c9080-078f-4f18-ba44-ab7bc40e7064","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P32240"}
{"id":"59dbfe31-322f-4de9-be85-a4e76304298e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996518","predicate":"biolink:affects","object":"NCBIGene:9622","sources":[{"id":"urn:uuid:04f4d395-2599-4cfd-96f2-be67c8d18186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10576","original_object":"UniProtKB:Q9Y5K2"}
{"id":"831dc9b5-9665-4f0a-a07e-054c51d6bff3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90309142","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:b802522a-4a2a-44a4-9f9f-d29f51cc1963","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9223","original_object":"UniProtKB:O95136"}
{"id":"04708b8c-f59f-42fb-b746-8a0e1a3c00bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11266452","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:ef1b3a4d-4dc9-4cba-b9c8-5ef9f6736861","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1752","original_object":"UniProtKB:Q15077"}
{"id":"310164d5-e793-4eb7-9aeb-32491c3729ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88307","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:358c60b3-38d1-4adf-842e-09cf3434fcfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:891","original_object":"UniProtKB:P30551"}
{"id":"977dd2a1-91d7-4ecd-b5bb-9781575de721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15990224","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:e3095ecc-4680-477d-92ec-7c23fbe76e7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7811","original_object":"UniProtKB:O60885"}
{"id":"1afe241b-c874-4a9e-92b6-a59797b8bd06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6TGA89COP","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:1f6d7677-db9a-4979-b02d-2272c700acdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:211","original_object":"UniProtKB:P28223"}
{"id":"1c255338-be7e-4153-918c-4478e5410403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155296110","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:1924aab2-7316-4b7a-a9dd-1410b397e1a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12381","original_object":"UniProtKB:P35968"}
{"id":"7652d659-005a-43c6-8663-5ec8842f670f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93436","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:316b627a-7412-4d5d-be97-b44e1e06b3ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11","original_object":"UniProtKB:P08908"}
{"id":"b16b9808-fe90-41ad-a229-a01c1f7e74b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10224714","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:6f1f4d74-14c4-402f-ba4e-f24d525269d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11065","original_object":"UniProtKB:P06493"}
{"id":"408d92e1-d164-4b34-a9a4-7399e3c55855","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139369660","predicate":"biolink:affects","object":"NCBIGene:6416","sources":[{"id":"urn:uuid:3b7663cb-15ac-4259-b789-ebce0533a86d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12376","original_object":"UniProtKB:P45985"}
{"id":"52570bef-2f7c-4574-af52-03e48d3e6f73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6LGR0RYY5Q","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:752f9054-cc09-426f-97ae-333affc1450b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13753","original_object":"UniProtKB:P49336"}
{"id":"ed2c7a9c-1446-41ca-9e5c-9c841999b15d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10308","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:6521b771-9dca-4d0a-a4b1-d07d41640985","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10308","original_object":"UniProtKB:P78348"}
{"id":"508d0b4d-f35d-44e5-bf04-75b8f8d512db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:175f417f-ae5e-4bc2-91e4-8ed8c771e6a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P34975"}
{"id":"9fa35711-0c16-4803-87aa-0330dc903189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:88633bdd-6495-4c2b-81f1-be772abe87da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P32304"}
{"id":"120bcd27-14c8-4789-9258-0d2900250f53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71734765","predicate":"biolink:affects","object":"NCBIGene:26191","sources":[{"id":"urn:uuid:94abd57d-d059-4c78-9781-d2351dddbb2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8856","original_object":"UniProtKB:Q9Y2R2"}
{"id":"6ab62662-8a62-424b-931f-37f5965a164d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6EJV1J6Y0","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:2c87ae86-19fb-4d5e-bc57-ced79564eda7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12287","original_object":"UniProtKB:P37231"}
{"id":"e36538e8-1cfe-43db-92b1-06b1371a21ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64122","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:3320c91f-44d2-4584-92b5-ff5cbf33053c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:960","original_object":"UniProtKB:P21917"}
{"id":"526a72c7-88d1-4732-a165-65b11e8697e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6701","predicate":"biolink:affects","object":"NCBIGene:1066","sources":[{"id":"urn:uuid:b24bb50d-ced4-4871-8f5b-14dcfc19bb40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6701","original_object":"UniProtKB:P23141"}
{"id":"8eca6be1-8fca-4a2a-9b35-8c2897b5a9d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177607","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:aa675faf-b89e-493c-ac16-76064a50c10a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9231","original_object":"UniProtKB:P21554"}
{"id":"6a0d89ec-bc30-444a-9bb5-a582d0c58a80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57928403","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:4d9c696a-2bad-49d0-950a-3aa387408dec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8315","original_object":"UniProtKB:P29597"}
{"id":"e6faa6a2-4832-4f79-82ed-e59d456b25ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:757","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:6964c4d4-69ab-4140-a1f4-c75633b30bdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:757","original_object":"UniProtKB:P51681"}
{"id":"c210dce4-1f0d-473d-932b-ccca95b88dce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:125111","sources":[{"id":"urn:uuid:a7985153-d6e1-43e0-a0e4-0873ea83d86e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q8N144"}
{"id":"707fd816-b299-45ef-a913-6076eb2112fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68181876","predicate":"biolink:affects","object":"NCBIGene:5063","sources":[{"id":"urn:uuid:8c973a3c-5781-4f4b-97f6-d60d6ce46509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8941","original_object":"UniProtKB:O75914"}
{"id":"386708c2-332a-431d-bf7a-60d765b3021c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51450","predicate":"biolink:affects","object":"NCBIGene:24326","sources":[{"id":"urn:uuid:59ec8498-8846-478e-8ed9-75740e5d474d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3494","original_object":"UniProtKB:P26684"}
{"id":"bea75af8-14dc-46c9-8578-b04e0eff2a53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9UO06K7CE","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:c38acca9-d126-41f1-a631-44698afd6c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13193","original_object":"UniProtKB:P08588"}
{"id":"aab6b29d-93da-4fbe-8139-f65d35340e3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312112","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:a56f751e-8372-4c28-9add-00c9fd498ba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:415","original_object":"UniProtKB:P29274"}
{"id":"e4a5c543-59b6-4afe-af86-133d53e24afd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3380","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:d0f362f8-03d5-4b46-aee2-f0075d7874a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5158","original_object":"UniProtKB:P12821"}
{"id":"1eac8970-e355-4b69-87b8-de8d185a53e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53578","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:e068c02f-b769-44d2-a3c3-7df3ce13eb52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6291","original_object":"UniProtKB:O75762"}
{"id":"38e3a674-316f-493f-b847-4c0ea3a87a45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9954280","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:57a5317c-4980-4e58-be00-61f02410856c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2699","original_object":"UniProtKB:P37231"}
{"id":"a1a35d52-c39c-4b1d-8f33-44198c03ecc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:7220","sources":[{"id":"urn:uuid:b7a2163e-af26-44be-84a5-4da35c2a0b05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2441","original_object":"UniProtKB:P48995"}
{"id":"54385c40-7078-43a6-af2d-3dd211515b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5720","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:e52bd40e-c041-413d-b17e-0881495608bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:324","original_object":"UniProtKB:P11229"}
{"id":"189c870f-21f0-4202-84f3-bfbcd6309585","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73358","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:b59acb1c-07fb-426f-b846-a0febcbfc2be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1652","original_object":"UniProtKB:P33534"}
{"id":"d92bb0d0-14b1-4a53-b3e6-4ad28e03ee16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:e107540c-eacc-4388-b40e-2728f66ac297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4156","original_object":"UniProtKB:P47869"}
{"id":"0fc0123a-5780-4bad-b740-d7feb25ff2d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:ea97a8ba-39e3-49e6-afdd-cefd130ef573","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:Q16445"}
{"id":"cba7ecaa-6d38-4855-b2bf-017697dadd60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4081","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:8d8258da-8601-4dcc-b6d9-9df5323bf552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:232","original_object":"UniProtKB:P28335"}
{"id":"11ba24f6-c1fa-47a6-969f-dd0575f636a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25172871","predicate":"biolink:affects","object":"NCBIGene:330","sources":[{"id":"urn:uuid:daa7834b-0570-4ac5-9bb3-e3f60b5c054c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7732","original_object":"UniProtKB:Q13489"}
{"id":"f03f6afd-287a-4c06-9fb9-6b1a59628091","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104872","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:a6c7a667-7297-413d-8ff4-e8f7aa8cd8cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5260","original_object":"UniProtKB:P27815"}
{"id":"94486704-d92d-4749-8c87-306af6195435","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135905416","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:ff97f7d7-61f2-4283-85ff-bb5c1d802e75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11779","original_object":"UniProtKB:O95271"}
{"id":"00b92726-bbff-4594-9721-33567b3779e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:3ae1e1ec-9b6f-48dc-a280-5c5471b6654c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P35367"}
{"id":"9f129fd2-62f9-4a8f-bde3-061d39eab1c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76649","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:2112a6dd-fa68-41e8-8cd3-a28671224e68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:925","original_object":"UniProtKB:P34998"}
{"id":"e62f0874-b8f5-4b48-877e-c5937bdaf5a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2233","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:05cea3e6-9fa7-4122-a73e-3589eebfcbb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2233","original_object":"UniProtKB:P30518"}
{"id":"716ee356-edd1-4507-8630-6f7d608a2998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233309","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:b5e9c6e5-aacc-431c-b206-e716f32d48fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10888","original_object":"UniProtKB:P01116"}
{"id":"36708dce-3979-4615-b4fe-fe787c3704d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2611","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:acccb119-5ec0-435a-9b7a-a4f4718858a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7111","original_object":"UniProtKB:P31644"}
{"id":"2cd91a3b-aa24-4da0-9216-342a512c5321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67271","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:87e51318-bf59-4bf6-9958-5ba322708a19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7945","original_object":"UniProtKB:P31749"}
{"id":"523c19ca-8054-4c56-ae07-6335686aa3c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135508231","predicate":"biolink:affects","object":"NCBIGene:25302","sources":[{"id":"urn:uuid:7c8021c2-f218-4142-a41c-dcede165da0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11385","original_object":"UniProtKB:Q05941"}
{"id":"c31c9072-7a7a-447a-85f4-2e3428268749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13718","predicate":"biolink:affects","object":"NCBIGene:26872","sources":[{"id":"urn:uuid:b3462d23-23fb-4f5d-9318-20e209c13ee8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13718","original_object":"UniProtKB:Q9UHE8"}
{"id":"c8868cb9-fab2-4991-aa4f-cff531e3df2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59751","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:5c5f5776-2811-452c-83fc-b9dc19f19314","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3476","original_object":"UniProtKB:P32238"}
{"id":"b4383864-80bc-4b69-b76b-a798238ae681","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611888","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:19054437-aa2c-4db5-b5e0-5faf972c81d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9968","original_object":"UniProtKB:Q13507"}
{"id":"8a187257-dd88-47b1-8483-99594aa6de0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139349","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:f7b9674a-2668-40ba-aa82-70040e442d91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2443","original_object":"UniProtKB:Q13507"}
{"id":"bb91f801-c03d-4122-bbe5-875b3c003a97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87202","predicate":"biolink:affects","object":"UniProtKB:P52189","sources":[{"id":"urn:uuid:07399f15-1b80-4653-a171-279be2314143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2393","original_object":"UniProtKB:P52189"}
{"id":"e2792514-8393-4ad9-a2aa-babdd4359f98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1331","predicate":"biolink:affects","object":"NCBIGene:17200","sources":[{"id":"urn:uuid:4850027b-ab91-424b-9610-241e7e3fa8d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1331","original_object":"UniProtKB:Q64326"}
{"id":"a3bb9d38-d59a-4d60-b0b1-800357ec34cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:ac9b879e-347b-488a-9f17-3c23ab34ab3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P21918"}
{"id":"f8a470ca-981b-459a-8c39-eecbce29e684","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131180","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:c485eb2e-0200-4d44-b4bd-a4eac6b97817","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:567","original_object":"UniProtKB:P26255"}
{"id":"f02ed887-67b5-44d9-8bc5-2a611a8a34a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"UniProtKB:A2ARP9","sources":[{"id":"urn:uuid:275f90d7-2d87-4bf5-97dd-288f95b2c466","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:A2ARP9"}
{"id":"10ce6148-9010-4c1b-80ee-255f2d86af8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:024be109-433b-4093-9f47-e455b822604c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P28335"}
{"id":"d796ddb7-baa0-43ff-b30e-7663bd48d9e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:4a341db5-404a-4b68-9313-7bdc02eef94a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:O60755"}
{"id":"04579769-a69b-453b-809d-67f3b650f61f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:5d67f46b-40c3-4dc8-86a2-1435725b078e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:P15389"}
{"id":"818d156f-8197-4b2d-a039-6db171f189a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:259232","sources":[{"id":"urn:uuid:8555a58c-2b63-4816-ac94-63857fffa55a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q8IZF0"}
{"id":"44424cd5-b170-48e6-8719-08b252fa465e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:3019c4cf-278c-46bc-9c0c-e7584f53b671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:Q62053"}
{"id":"d60b1673-d081-4013-a6b0-ca5f4def9ab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43065","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:5f29a517-2023-4c55-ad25-4a5fdf26ad84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12418","original_object":"UniProtKB:P49019"}
{"id":"c6ee0447-fe14-4aae-b242-943461e077f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:9bd0826d-6652-4d15-a783-c103d7ee312e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q9UKV0"}
{"id":"60cf22fa-6787-4ddf-a033-6e7a74a2bdec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:8b0c5533-7b98-4f98-bdde-0d45f3bbca34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:Q08345"}
{"id":"a321a3fa-5eed-4478-b5de-434a29d7b00f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996536","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:003da157-347c-46ec-836f-3e351a4eb6fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10649","original_object":"UniProtKB:P42336"}
{"id":"c9af04b3-9c28-4f6a-86a5-0a2572ebc7d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817412","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:239239b1-d6f4-4fb1-a053-7cf422aabc16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1472","original_object":"UniProtKB:Q9GZQ4"}
{"id":"d1700943-d73b-4a44-8182-6985dfbdf2d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2914","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:7f7e7703-991d-4565-98f0-397c07671cf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9537","original_object":"UniProtKB:P32297"}
{"id":"61743ed2-2aba-4a43-9a4b-5aef7124355a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JJC99KHGL","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:0481de53-3fd3-477b-a059-3ca424bde062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11118","original_object":"UniProtKB:Q13547"}
{"id":"a07ac505-1ce5-4b19-b99f-05660779909d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4198","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:c732bd77-65f5-4d61-8096-c5020087b44a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4198","original_object":"UniProtKB:P13569"}
{"id":"0e49e04c-4ad1-45d3-b139-bf0782ef61a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11282871","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:31e28877-ef6d-4bb9-997a-bee9405a7f55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5737","original_object":"UniProtKB:Q8TDV5"}
{"id":"ae9265b1-962c-42b0-95bb-5aa27b60fdd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138111","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:48f82f9c-eb01-43d2-9f24-b881367622c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6314","original_object":"UniProtKB:P35414"}
{"id":"275a8334-34b9-435e-b50e-0fa89c6478b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4650","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:fcdd372c-7e0c-4ac6-aaf8-1170e1191dc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1617","original_object":"UniProtKB:P41143"}
{"id":"da36eba8-d1b7-42ad-8bdd-31ddd2c25e9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9953271","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:71908860-e294-42c3-adcd-d7d705463099","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2663","original_object":"UniProtKB:P37231"}
{"id":"3ba7ce6f-887e-4596-86dc-f7682863cd0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:1a02bb1d-38fa-4f68-958c-9a80fdbb4e32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P35462"}
{"id":"1570f6ca-eef1-43ec-b446-d971bf13bed3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6437","predicate":"biolink:affects","object":"NCBIGene:117559","sources":[{"id":"urn:uuid:890bf938-67b3-4637-b4c4-74ce8b6d30ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6826","original_object":"UniProtKB:Q02563"}
{"id":"a634a6b3-65da-40f8-abb3-80becdd05ae5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:7c4dcd98-ea48-408d-bdbe-c8f65eb22a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P50406"}
{"id":"ab32739d-5ef9-4bd6-b777-c0ae3097879b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89560738","predicate":"biolink:affects","object":"NCBIGene:25153","sources":[{"id":"urn:uuid:14f960cd-be6f-4d6a-8104-382290fd4b91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7039","original_object":"UniProtKB:P12526"}
{"id":"8eaf1c95-b6d4-4df5-bbf4-14016f8c19dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I3O3W6O3B","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:d1ee6aba-5382-4cfd-a898-2a423b95641b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7889","original_object":"UniProtKB:P43405"}
{"id":"5f7c85ab-5846-4698-9edf-b4f84d53a5eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O5CSC6WH1T","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:077a610d-b3ff-4dd2-a9dd-737a773e735f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9234","original_object":"UniProtKB:P34972"}
{"id":"6aebb7a1-3519-4bf1-9f98-7e7b59d572b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53364540","predicate":"biolink:affects","object":"NCBIGene:747","sources":[{"id":"urn:uuid:4d757a0c-2b3c-4df9-bea3-17c84f997c67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10245","original_object":"UniProtKB:Q9Y4D2"}
{"id":"582c603b-3ee1-4fbd-a242-9e6e35e74944","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3700","predicate":"biolink:affects","object":"NCBIGene:8549","sources":[{"id":"urn:uuid:249dd7cd-9933-4711-8586-831f14b40b09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3700","original_object":"UniProtKB:O75473"}
{"id":"087657c8-b13a-460c-8538-8f8a7254181e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946726","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:b7cec373-a676-40ec-a61e-82dd7c9b5c85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12238","original_object":"UniProtKB:Q6V1X1"}
{"id":"f6f312aa-6db9-4d4e-adcf-ae61ca0f9925","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:f5e59b55-f4bf-4e49-b8d8-c0a854fdb972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P41180"}
{"id":"1f8324ae-f06d-42b6-ada0-54d595dec64b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42519285","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:61437378-909b-423f-a662-98673cc1fd04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8591","original_object":"UniProtKB:P11229"}
{"id":"8f024f43-8ef6-4740-bfc3-4050700321fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10090192","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:c1d4fbe6-0453-4db8-97a8-f9c862dc9c56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2652","original_object":"UniProtKB:P10276"}
{"id":"d02834a5-07be-4fb2-ab8c-1d3ccb76f9ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:802b4ed9-9cda-4be0-ade5-559afaae7611","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P14416"}
{"id":"5516bfa8-a431-40e8-abe1-66d0c2e0f492","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91706","predicate":"biolink:affects","object":"NCBIGene:16514","sources":[{"id":"urn:uuid:bd607f1d-24d9-47de-9e3f-205845a634e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2412","original_object":"UniProtKB:Q61743"}
{"id":"5ab6b844-8b95-43d0-96e2-b4b37f32bbfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3210","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:a35531fb-afe5-443a-ae89-7eedf77e51b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:144","original_object":"UniProtKB:P28223"}
{"id":"748e7801-ec10-475f-a7c5-5dadbbdbcbe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813884","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:659ea1f2-5034-464e-b05e-86d54a4d2aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3890","original_object":"UniProtKB:Q13324"}
{"id":"af0baff7-23db-4386-9bf6-9d6ee29422db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SAY8KVM4HU","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:ce97da61-4ce5-40ad-a7be-b2d6a39596d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12614","original_object":"UniProtKB:Q12866"}
{"id":"5c6fb55d-4fe4-47ca-a3de-90e1b1815dff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1105","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:28799765-90db-4f89-9079-07b7eedeb577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1105","original_object":"UniProtKB:Q02644"}
{"id":"4bbb20a2-12dd-4ff4-adfc-5fc8ea953d2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132129813","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:c7e90e3a-0554-42a2-ae62-370591a68a43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"non_competitive_antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11232","original_object":"UniProtKB:P56373"}
{"id":"df65903f-c7c3-4cfc-bccf-9af2ecbb1e86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:672548","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:8cf496d2-4300-4965-b162-101d073bfa39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7510","original_object":"UniProtKB:P25440"}
{"id":"e4a090d9-feb8-459a-8fb3-57f50e6401d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947087","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:417522a3-bf49-4c94-9b65-c00a5de9133d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3207","original_object":"UniProtKB:Q62967"}
{"id":"f4936323-23e6-429a-a33f-7038fe153a3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:63f063f0-0674-4a64-9907-1403813df3fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08912"}
{"id":"20a68bbd-15c7-4d20-8edc-4b5d05b81aad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131788","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:7cd97a1c-b150-46a2-b1f5-166858f9ffbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1363","original_object":"UniProtKB:P48039"}
{"id":"f261192e-f959-4812-b60b-d49778b1a96a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9058I8S63D","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:88e0fc01-d474-4240-b89d-f88deedaffc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8012","original_object":"UniProtKB:P42336"}
{"id":"83b32189-6220-4bb3-a637-ea908a10a2f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8888","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:93b2b728-3924-46af-af1e-e51bc6f5189c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7295","original_object":"UniProtKB:P35462"}
{"id":"a5a5146d-1d2e-47f6-ba57-d6026a74aefc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8977","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:89f60e32-45b7-4a30-80c0-52f7ed237ba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:189","original_object":"UniProtKB:P28335"}
{"id":"112ad411-20df-46d8-83df-25925854e60d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3860347","predicate":"biolink:affects","object":"NCBIGene:9446","sources":[{"id":"urn:uuid:9143904a-0a8f-4044-a718-4306cd5f9047","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10719","original_object":"UniProtKB:P78417"}
{"id":"03f46236-237d-48e3-8f49-fa93ecb0fd46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YTL7A418KQ","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:5a2cbb12-d9a6-4901-a3a7-141e14c87443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8391","original_object":"UniProtKB:Q9UQL6"}
{"id":"d212116d-76ad-4d9a-b923-4e6283f07c7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6GM6ZN5S1Y","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:daf75bdd-3bb4-4018-afd6-2627c5b31730","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5868","original_object":"UniProtKB:O08725"}
{"id":"86491192-2d80-44fa-a3fa-1bdfead9762f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6128","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:14d2a196-eb4f-4110-aa9e-94c494467e32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4795","original_object":"UniProtKB:P23219"}
{"id":"65a4d241-c1b9-4208-aec8-5ef8dd0b78bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80555","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:5693829b-50a0-41ab-a14d-53dffe6fc3c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10203","original_object":"UniProtKB:P11511"}
{"id":"5c10337b-6e6a-4fa5-8529-df037df78d0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11496610","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:411c966a-33d9-4499-9707-44b21a917c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5582","original_object":"UniProtKB:P30969"}
{"id":"7994bdb3-8416-4ce9-a464-52b33da15fb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:617","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:ab6da315-b841-4770-82e0-d1f85a7d1b74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:617","original_object":"UniProtKB:P24053"}
{"id":"9f43fd32-db3a-4b25-8b07-84fa4c96f73a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L7DUG75C36","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:5b338e5a-f868-4a1c-875b-514cef627c83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10128","original_object":"UniProtKB:Q86WV6"}
{"id":"7ddaf75d-ef79-44a3-a661-63d726e02e96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841560","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:7e911a8c-8d6e-429b-8335-58bcc5663d35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9541","original_object":"UniProtKB:Q99571"}
{"id":"cc023ab9-da70-4150-a49b-62301ffc32c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:e5c2da19-518a-4d72-8079-74f06b48a9e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q99250"}
{"id":"ae12d461-6a23-45c9-b363-1b475379fcf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87784","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:46093c11-02a4-4d44-bf98-560f098ffd55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2303","original_object":"UniProtKB:P46098"}
{"id":"00d69f77-eb77-497b-917b-7af135a0d068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5395893","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:053261e4-0691-4198-b3e2-1132e8749e8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13103","original_object":"UniProtKB:Q9NQS5"}
{"id":"8c552e56-b320-4303-aae5-181910bfc89a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45100481","predicate":"biolink:affects","object":"NCBIGene:10434","sources":[{"id":"urn:uuid:173749e2-7e0b-4237-9891-a144c52fc5c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13414","original_object":"UniProtKB:O75608"}
{"id":"c287b3ec-07c2-4f85-a13e-63cd7b24984e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182364","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:1c075d82-b710-4040-bf16-53a1b14cc833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8144","original_object":"UniProtKB:P37023"}
{"id":"e2411b56-b7b3-4be4-a75b-38dec06ee7bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:51305","sources":[{"id":"urn:uuid:6409b8d8-df7d-46bd-8361-1ea1f6ffbc48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:Q9NPC2"}
{"id":"2021284d-3375-4920-a96d-4407a712f6a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:a10c7f2f-55c6-4004-9722-d31b6fef7c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:P56479"}
{"id":"dd2e842d-700f-4261-987b-b840be5c139a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:fb35d75b-2777-427a-823f-32c9946d316c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:O88626"}
{"id":"76442d96-88b5-4b51-8774-af468c5292d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311417","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:c0c94c48-8fb4-42d1-b69b-e2362a3bc387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:236","original_object":"UniProtKB:Q62758"}
{"id":"711a7897-9b3d-49e8-a1c8-d182b1686dfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6925","predicate":"biolink:affects","object":"NCBIGene:5499","sources":[{"id":"urn:uuid:0f44f1f6-cdaa-4829-9c2d-16d2419e537f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4735","original_object":"UniProtKB:P62136"}
{"id":"6071fd22-7e2a-4bba-b783-4f12a13f9002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71580550","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:b282eb7f-3f10-4f67-bbb8-79632216c021","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6451","original_object":"UniProtKB:P41594"}
{"id":"e7e151bf-5e80-4824-801b-a63c0e73112b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28172","predicate":"biolink:affects","object":"NCBIGene:17161","sources":[{"id":"urn:uuid:a6254149-133f-4cc0-9374-ad10702d8b8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13140","original_object":"UniProtKB:Q64133"}
{"id":"1ccbef97-2263-476f-89c1-21182a16a2d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438353","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:bdc5c736-5460-42a1-9912-5b2e9fc8445d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1634","original_object":"UniProtKB:P35372"}
{"id":"7b2ec8e0-31a0-4bf2-bd2a-4650df5dd60e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4043841","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:7bc7b018-e0ac-48f1-b1c0-c1aa0709638a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10238","original_object":"UniProtKB:O00222"}
{"id":"07f0bede-430a-4463-ab70-08175154e4ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135285","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:eaabde28-4fc3-466e-80de-977dcf6eb50c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6310","original_object":"UniProtKB:Q9HBA0"}
{"id":"24702560-1fc1-4e9a-929c-349ec888fd65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:5e93a535-5a20-46cf-88f8-7b604b6ab9e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P28223"}
{"id":"e27bb07f-f104-4c6e-9408-736a2ef01e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:62166","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:16125da8-8359-429b-a79c-d5bdbadceb88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9173","original_object":"UniProtKB:P07947"}
{"id":"d27f7f16-5f53-46fb-9819-65eca74876f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7949","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:4e195308-f56f-45ab-80c5-92e7f03b85f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7949","original_object":"UniProtKB:O14965"}
{"id":"15acffe3-cc64-4d91-9b98-b501cd7288d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135355941","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:703c5554-6148-4249-9f47-0eba4f33a99a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11791","original_object":"UniProtKB:Q06187"}
{"id":"977aff12-28c1-411f-ad09-647d38c0fcc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50861","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:a78ffde1-194d-4859-8847-45788e72888e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5820","original_object":"UniProtKB:P43115"}
{"id":"62693d2a-bf4f-4526-8525-7d88fd3719bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1018","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:88fc303d-01b3-4d9e-b1e8-7fa0c7ff02f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1018","original_object":"UniProtKB:P21462"}
{"id":"d0983732-4f2d-4f77-9c4d-088e50e3e51a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92250","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:1ccecc53-1d08-4860-ad78-fd395170cb70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:18","original_object":"UniProtKB:P08908"}
{"id":"aff6eb43-c000-4ccf-81c9-37f6ad120450","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168313548","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:d30c2704-0ebf-458e-86e4-8678fc3d8939","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10345","original_object":"UniProtKB:Q9Y2T6"}
{"id":"53a75e10-f8b2-4967-9a37-5a276e02270e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93015","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2500193f-e081-4fc2-9350-2622d40257dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3274","original_object":"UniProtKB:P08172"}
{"id":"54e17c74-1cf1-4941-b812-f26ec462e551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:eda40e3c-f9e4-4b66-9b3f-fc4cf01ac86a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08485"}
{"id":"c0ff526b-7a3c-4fec-b4fd-91157e3f4730","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3677","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:7333ced0-ac4c-47e8-b133-7bf23cbc883e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3677","original_object":"UniProtKB:P25025"}
{"id":"10f13e31-7014-4db3-b7ad-c96bcfb18d2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82715","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:944d8277-32e7-4c49-a28a-247e08175554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7818","original_object":"UniProtKB:Q15759"}
{"id":"2f99017d-8384-41ee-8001-273441e15cd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:0a360b7b-a96c-4101-a2d0-75597b3d00cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P29276"}
{"id":"0c583064-815c-4865-8284-7c42e0879fc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68649","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:c0a57f0a-323d-4264-9ba3-2c6b086f9162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2169","original_object":"UniProtKB:P30518"}
{"id":"caed4494-6343-4397-828b-7bde649bd3a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O519NVW73R","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f9713134-c9bb-44aa-9e69-6f46a9949c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11221","original_object":"UniProtKB:P30542"}
{"id":"724d948a-0929-483e-be40-bdb1077c0e77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162462289","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:65f67cdf-ab88-48a8-8b30-e802cbbeb5b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13903","original_object":"UniProtKB:Q5S007"}
{"id":"e2cdae67-ff14-49c4-ae26-cfb3b8538c82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3856","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:f034dd25-8c22-4a40-898d-a2fb0c0d0ad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3856","original_object":"UniProtKB:P48145"}
{"id":"900b4ca6-eb3a-4e00-8664-daa4a2f8f2cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9555","predicate":"biolink:affects","object":"NCBIGene:3614","sources":[{"id":"urn:uuid:066e133d-61c3-47ae-b114-bcea8a0b10a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6845","original_object":"UniProtKB:P20839"}
{"id":"8c28ed4f-11b4-47d2-b0c2-561eab838eb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2610","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:bd1ebfe6-dcf6-44e2-bfd8-4a5cb4fbdf2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2610","original_object":"UniProtKB:Q12809"}
{"id":"2a8ea76f-4f6c-478b-ae6a-c611f657c8d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52140","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:8450e708-3415-4985-8c28-1b1e2804648e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10285","original_object":"UniProtKB:Q9UBN4"}
{"id":"7350894e-85b9-489d-adff-633ab34e35e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135197617","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:43d3cfb7-2dff-4d18-b1fd-65eb0f94c6e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10441","original_object":"UniProtKB:P48736"}
{"id":"cbc2b075-ad19-48bc-89c3-5a799753190b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167600","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:614f20ce-9c53-4d91-9a94-76a1fcd99412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9619","original_object":"UniProtKB:P29597"}
{"id":"b214f4b6-fb09-409c-b1ec-f0983b1e4e53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230501","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:51285e5b-7186-439b-bda5-d110e69d7947","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7491","original_object":"UniProtKB:Q9UKV0"}
{"id":"463140fd-f2f8-4f7d-b260-01a4e2ba152c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63619","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:ef8c27e3-1151-4708-859f-62934923db28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2561","original_object":"UniProtKB:P08588"}
{"id":"117a74bd-0a26-4bf8-8961-4c017fc1fe76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4L1AM42NVA","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:ad1429da-3fa1-4315-999b-947bb2143562","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7971","original_object":"UniProtKB:O60674"}
{"id":"b0cb85fe-9a5f-4275-9877-55bbcfa2a90d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817433","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:0038adf4-6d67-4505-ab01-7d22b667ff3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1827","original_object":"UniProtKB:Q03431"}
{"id":"b4601f0c-5bed-4029-89aa-a4ce6aa3e654","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5YL4IQ1078","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:0de6adf1-1a11-456a-b7a6-934ebac0e554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8310","original_object":"UniProtKB:P19099"}
{"id":"1c483ab7-3d88-4f0c-925d-37943f49346f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10864183","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:fc4aae84-e9a9-48de-9a0d-641987d43b85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9838","original_object":"UniProtKB:P41143"}
{"id":"8bf3ea32-d975-4dfb-8242-52e0f3fc25ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:71d045d6-0c5c-4877-a69a-39bf53f43898","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:Q14416"}
{"id":"7e8a2b11-1f09-4e33-8546-d3b2df85bb6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567102","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:9d337ac9-b9ee-407e-b061-c515f3ac7055","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12661","original_object":"UniProtKB:Q9UQB9"}
{"id":"21f3350b-c70e-46b5-9c19-d5e9e31224cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124930","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:ea081a57-50a2-4c5f-81c5-e73ed36de1c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8062","original_object":"UniProtKB:Q9UHD2"}
{"id":"e82ab271-d8aa-4891-97f8-f79c9764dea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:2ef3008d-3d61-4ce6-bb5f-48e561c5cd93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P49336"}
{"id":"2f3ba6e7-6105-455d-91b3-1373c3bba832","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138236","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:aa95524d-fc3f-43f6-866a-06c0b08816bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13088","original_object":"UniProtKB:Q96P20"}
{"id":"20544c71-52e2-421b-9464-cc15dd2ef9f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156274380","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:9ac00f06-a010-424e-b3e2-233176beb2ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12909","original_object":"UniProtKB:Q12852"}
{"id":"1b19edef-ea3b-4ae6-b860-24185f6bd22d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5700","predicate":"biolink:affects","object":"NCBIGene:8973","sources":[{"id":"urn:uuid:a1e23ed4-c13b-4048-9d60-2dfbcabbd9c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3963","original_object":"UniProtKB:Q15825"}
{"id":"33223440-bec9-418b-97a2-0ae400df3792","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755011","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:7fd85ea5-2d20-4631-88ac-6f96a3a1881d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1836","original_object":"UniProtKB:Q62035"}
{"id":"2dc6c9be-81fd-4fca-aad9-54bb68971647","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:672296","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:6df83091-0591-4a0e-921c-8df790f8d78a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6048","original_object":"UniProtKB:P43405"}
{"id":"055a90d0-c68d-4226-9281-9c5a9f5ae9f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:206839","predicate":"biolink:affects","object":"NCBIGene:8078","sources":[{"id":"urn:uuid:2a31b3b5-5204-4208-93b9-e8a4fcc3ea95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8669","original_object":"UniProtKB:P45974"}
{"id":"8fa33849-1e06-4bc9-b883-3f9df33459ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2564","sources":[{"id":"urn:uuid:74206811-5507-4635-8858-e51aa738a9b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P78334"}
{"id":"c21ea6fc-604f-41c5-9d3d-2e1dc09fa591","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180961","predicate":"biolink:affects","object":"NCBIGene:20186","sources":[{"id":"urn:uuid:b3b7d0ec-9344-4702-a05c-9c40da158a3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2745","original_object":"UniProtKB:Q3V1T8"}
{"id":"73e92ff6-f27b-41de-abd1-6b176fb90f7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189652","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:f008b998-2424-4456-abfa-07e7a3b7ac8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10728","original_object":"UniProtKB:O60885"}
{"id":"4e93ce6d-30a0-4376-af20-24165dcf28f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8586","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:38e51168-bfc1-44fe-87ae-dd905edf9aa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8586","original_object":"UniProtKB:P08912"}
{"id":"6c0eccb2-d27e-403c-9b2a-3b744812f33e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:776d84a6-e287-4560-a79f-34bc2e7b4369","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P32305"}
{"id":"90e0548c-f765-41cc-b72c-99ef1ca4f6db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38322","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:ec9e5ab8-4092-4087-8a99-0a728fb43f51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:303","original_object":"UniProtKB:P11229"}
{"id":"f4ca0b69-c3ea-4887-9b19-5f59237cb78a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:22068","sources":[{"id":"urn:uuid:8339ae8b-7560-4989-a095-02e103e7b18c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q61143"}
{"id":"65c36c42-e94d-4ae3-9545-78fd20fc99f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95049","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:a2892d23-cad1-40e3-82f1-e906b17570b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9375","original_object":"UniProtKB:P28482"}
{"id":"bc0c812e-c1da-4b33-aea4-e0b761847920","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T4W68CAT3P","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:bfa2a7f2-9219-43ac-bb07-ea520e5c6f4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5690","original_object":"UniProtKB:P07333"}
{"id":"1d519c01-38ee-4923-8ad8-0736af4b7473","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93452","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:98d77be9-8830-42a4-be69-5bdb85e615d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4296","original_object":"UniProtKB:P14867"}
{"id":"34eb5085-ea70-43f5-9aee-a2734cbe5b08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67617845","predicate":"biolink:affects","object":"UniProtKB:Q02768","sources":[{"id":"urn:uuid:9ee7c41c-9536-4705-87fa-310073067ac4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11263","original_object":"UniProtKB:Q02768"}
{"id":"dc093f96-1904-4c18-af32-b73f867cf231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755173","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:31bd9516-157b-4d77-a70a-8b096f4f6df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6071","original_object":"UniProtKB:P21731"}
{"id":"d95b0fb9-f367-4bdc-b2a6-f8f5f8a30e28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10148412","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:113ea87b-0ac2-454f-a562-3f14d4ab403d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1473","original_object":"UniProtKB:Q9HB89"}
{"id":"b1cb28ca-8dae-4f18-b435-a15fe3dc2d04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16036762","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:04b3d633-9ce9-4061-8a3c-95f91ff9c47c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6396","original_object":"UniProtKB:P31424"}
{"id":"a596bfd8-b58f-41f8-99e1-cfe041290922","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2066","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:6f027933-16e1-459b-8eb1-df37f4597a48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2066","original_object":"UniProtKB:P30680"}
{"id":"b9f76ec0-3eed-47fb-9e04-cca356d4fb18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:e1f2bf27-2451-406d-bc7f-8b692c6dff1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q9BY41"}
{"id":"fa67a984-361c-4c0b-a65b-33599854575f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5472440","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:f1fb111d-1596-4ff9-bbb4-dd7ba53a132c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6302","original_object":"UniProtKB:O75762"}
{"id":"016e6b3a-4a64-4206-8572-a24ccee1950d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S5016F5ZH4","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:d70998a0-da2a-4268-ab7d-9371f623070f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13015","original_object":"UniProtKB:P25101"}
{"id":"58439c82-c413-4d7b-927f-22d968e09f05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92560","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:ad9d7358-0db4-484e-ba66-fb35cfa6dc2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5163","original_object":"UniProtKB:P05771"}
{"id":"6970fa13-9b43-4dfe-9df5-8a4e52ded621","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24749950","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:4cbe7502-e605-481d-9300-415e8585d824","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7923","original_object":"UniProtKB:P49286"}
{"id":"71651d2c-1f8b-469e-9734-1c4e8ee4ddee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155411202","predicate":"biolink:affects","object":"NCBIGene:7994","sources":[{"id":"urn:uuid:e9af17b3-ee09-416f-9dca-cc82cc74b6c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12938","original_object":"UniProtKB:Q92794"}
{"id":"6fbd63c6-6e82-4d96-b03e-a2397b7a0379","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69453339","predicate":"biolink:affects","object":"NCBIGene:1186","sources":[{"id":"urn:uuid:c8efc3ec-e877-49e0-b1c8-2ec6581edcf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4275","original_object":"UniProtKB:P51798"}
{"id":"6e1f7e9d-4ca2-4cae-b83c-165e25b0a58a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754990","predicate":"biolink:affects","object":"UniProtKB:P31387","sources":[{"id":"urn:uuid:a7214038-07b4-469b-b16e-1a1a0592818e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:261","original_object":"UniProtKB:P31387"}
{"id":"6e4c1356-bf00-4eb1-8f37-d3f28662f8b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60167849","predicate":"biolink:affects","object":"NCBIGene:7398","sources":[{"id":"urn:uuid:2dcad779-17da-4b4a-8b04-22fecf19f7ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7898","original_object":"UniProtKB:O94782"}
{"id":"bdebaeeb-659c-4564-80ca-0df2fd525589","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135463043","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:7bbe9350-7308-4cd6-8256-fdb8c4641a97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6449","original_object":"UniProtKB:P41594"}
{"id":"1656063a-bd63-47ac-b564-de4de633ecaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44232532","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:96bd6e44-bbf8-4809-9dda-c753c74e535c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10274","original_object":"UniProtKB:Q8BLA8"}
{"id":"34c5fc1f-b669-4ec8-84aa-576c883f5212","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y66IS3CS0R","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:f46d21b1-2b80-4090-84ea-14da53de1680","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7969","original_object":"UniProtKB:P36888"}
{"id":"4f29f79c-fd14-4314-81da-196e069f156f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50692","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:a31c0c4e-ff5a-4420-9e41-f83bdb575304","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"mixed_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2805","original_object":"UniProtKB:P06401"}
{"id":"d3f9c928-55e2-4a8a-98aa-5aa2fa1b168e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1030","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:8f885adf-b099-4001-8f61-4f3db830417e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1030","original_object":"UniProtKB:P21462"}
{"id":"1f65d5d5-72f3-49cf-a01a-b99ad53791b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156612914","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:ec6087ed-9e09-444e-a1e9-c1d2af870f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11751","original_object":"UniProtKB:P56817"}
{"id":"bf068cea-2a67-4431-8674-2c979ae741a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60152613","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:2caa3ddb-4eb7-4f5a-8831-20061bc8e95e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13942","original_object":"UniProtKB:P04049"}
{"id":"a10397ca-2c03-4f56-9188-8d5bbef40a27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126961334","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:0352f1cf-a45e-4d44-9e36-d3020ff583ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9585","original_object":"UniProtKB:P55085"}
{"id":"21f4507a-34b6-4d22-a335-eb9e59d84c49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9C8MNF7CA","predicate":"biolink:affects","object":"NCBIGene:25149","sources":[{"id":"urn:uuid:190def52-e526-4f20-bfc7-d72cc11b9785","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6700","original_object":"UniProtKB:Q62986"}
{"id":"d8c51bff-c4e5-4b62-a684-52ee954f2ab0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46901383","predicate":"biolink:affects","object":"NCBIGene:5587","sources":[{"id":"urn:uuid:83144a9f-4364-4945-9fca-c3d28063691b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9370","original_object":"UniProtKB:Q15139"}
{"id":"e7d16498-01c5-4522-b65d-131864d5af9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12512","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:a9a31124-2606-4215-8fe0-515cf08198d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12512","original_object":"UniProtKB:P35372"}
{"id":"dc30fcd0-4a15-4c94-a709-a898e47aa531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137408242","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:82028724-6f4e-43ce-a11d-ddbf66737d54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12379","original_object":"UniProtKB:Q13546"}
{"id":"66714f5e-9d88-4d9b-aaa7-fde91bf05160","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168429725","predicate":"biolink:affects","object":"NCBIGene:14652","sources":[{"id":"urn:uuid:5592e533-5a2f-42d4-8042-d4736b2c850f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13383","original_object":"UniProtKB:O35659"}
{"id":"74e16863-969c-4644-aeac-500f80b63cf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4023","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:a48c0b0d-d4ee-49c4-a82d-4dffbdf15ecd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4088","original_object":"UniProtKB:Q13224"}
{"id":"c1bfe58e-9814-453a-a3f5-ce24eef6c1c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91398","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:6ea38b91-31a5-484a-abaf-0e2d717efa96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7948","original_object":"UniProtKB:P08581"}
{"id":"2221a6df-401e-44a6-aeb4-76a92abc6767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:28P3DU6DB3","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:b0fb1133-b093-4d51-8a07-f7168287a16f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12715","original_object":"UniProtKB:P03372"}
{"id":"a412aa2b-4d0f-46a2-a69f-f210aad70e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131954527","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:e8a5f4ca-3177-4300-8bd0-2184dc58db1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12526","original_object":"UniProtKB:Q9Y210"}
{"id":"bc7284f8-3cbb-4e90-b040-7900c468cac9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:9a16f8ae-1e19-4baa-84d6-de15f398f44c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:Q9Y210"}
{"id":"2ee3b6f9-638a-432b-9164-23a6ab38d6b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YB1F0V77MK","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:64984746-ab3a-4057-895a-d7c375a92a0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6155","original_object":"UniProtKB:Q15722"}
{"id":"823cee84-ccf8-461a-a023-967c5e7abe11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197431","predicate":"biolink:affects","object":"NCBIGene:2900","sources":[{"id":"urn:uuid:c33aa093-83da-4a21-b1c4-aa20fe42b5d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4185","original_object":"UniProtKB:Q16099"}
{"id":"f291ca91-e1b3-433c-a54f-4422ba6e5c46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81527","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:71d93320-e807-4b16-95c7-36f2f489bf04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1631","original_object":"UniProtKB:P41143"}
{"id":"b3f1aea9-9672-4f84-bfd6-7978df102d1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I4965C6W4O","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:2ed6afe6-52b4-43bf-93a3-89b1fe0c61bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8248","original_object":"UniProtKB:P23443"}
{"id":"4289c542-031e-4cbe-b3c1-0034cae362d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4018","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:f5179aca-10e6-4c79-83c5-2b6b9c6be08c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4018","original_object":"UniProtKB:Q9GZQ6"}
{"id":"e06a582e-b244-4cbc-ae39-00a3ea66b473","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G82N555U1N","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:ce88e230-c3b3-4828-a70b-77497549e2f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3520","original_object":"UniProtKB:P34998"}
{"id":"9511ad70-32c0-48fc-80e0-8a6aee1e7c2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5002","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:67430ba3-3429-4d78-a50b-fb994696760b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:939","original_object":"UniProtKB:P21728"}
{"id":"03a1d7aa-8c8e-4747-9361-180a08966d49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:bd538a62-23be-4ac8-aa13-88a92b409da9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P28223"}
{"id":"4eb7c17d-c935-4956-a5e9-a6cc930279f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57382073","predicate":"biolink:affects","object":"NCBIGene:1524","sources":[{"id":"urn:uuid:18cbf3f1-7e0d-4ca3-b60d-dfccbbbd9223","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10390","original_object":"UniProtKB:P49238"}
{"id":"d16d65f5-d1cc-48f7-b1b9-5f81e0fb3708","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2810413","predicate":"biolink:affects","object":"NCBIGene:9388","sources":[{"id":"urn:uuid:95f65d27-1420-4a79-be5a-fa4cbac6410c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6697","original_object":"UniProtKB:Q9Y5X9"}
{"id":"bcc3d637-5a12-4798-bde8-aa1ea5d93c47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101205709","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:d60ca25d-cb78-402e-9464-5f9907e30b8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1573","original_object":"UniProtKB:P30989"}
{"id":"77da36be-d6f2-4e6b-ae51-da3ab72b4771","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1110","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:b63e9f00-7623-475d-9531-69bd593e184f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1110","original_object":"UniProtKB:Q02644"}
{"id":"9afb1295-f5f4-43c9-94c6-0c09b3210cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135492054","predicate":"biolink:affects","object":"NCBIGene:10057","sources":[{"id":"urn:uuid:33cf5309-25f3-450a-9f06-5b1d2d4a5726","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8829","original_object":"UniProtKB:O15440"}
{"id":"d713c248-2d63-4215-8c14-05e7fa0563cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:9f42cbb9-e1cb-434f-9b96-9bb11e848517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:P04775"}
{"id":"d91efb71-641e-4db1-b0ab-3afb329fd6f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:6d646c17-6ed2-45e0-8c81-0a8e9681797e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P20309"}
{"id":"ed8f609d-26fa-4fb4-a721-64caef63b7c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2379","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:60d623a3-e9cf-4f81-8337-b515245479dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7107","original_object":"UniProtKB:P08588"}
{"id":"590c1f2e-59cc-4f53-a912-ce9afbe13039","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7762","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:8cb4ae35-2dae-4665-b46b-091ea15840db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7762","original_object":"UniProtKB:P15387"}
{"id":"08c3f40e-fd78-4af0-90b3-520709dadb8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59660","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:6a23ca67-7152-4992-bc93-ed321e400877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10347","original_object":"UniProtKB:P19793"}
{"id":"7f80c6a2-1ec0-4ea2-9afe-72331f98afa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95093","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:c6714f56-01c1-4a42-8363-69a6376b2936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8974","original_object":"UniProtKB:P42338"}
{"id":"73190092-56f2-45ba-819f-af7845021150","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YZ68ZB8LWA","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:e97406e8-1d44-4bc1-a36c-9bd25189d85a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11666","original_object":"UniProtKB:Q06187"}
{"id":"907e516f-4833-4812-a506-369db71330d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22359367","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:55ce9adf-61d6-4697-bf1e-c41e4eb1e4ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4107","original_object":"UniProtKB:P24046"}
{"id":"0ad1e331-00a7-4451-8fef-d5de4cef867b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16488","predicate":"biolink:affects","object":"NCBIGene:10392","sources":[{"id":"urn:uuid:fc2af3e7-694d-487e-986d-7b23b25e163f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5021","original_object":"UniProtKB:Q9Y239"}
{"id":"63bfd5cb-bfd7-470b-b5bf-56958aa684aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162526515","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:eb993b4b-567c-4bf5-84a4-7dc08d4343e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12141","original_object":"UniProtKB:O60885"}
{"id":"fc6b45ff-7309-4f94-97b5-2953f2f7ed6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46872626","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:d6c5973f-2031-4f91-a5c8-4667f1bf3e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9496","original_object":"UniProtKB:P21453"}
{"id":"ea043f60-93a6-4a75-882d-7319ed380f96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J0FI6WE1QN","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:e8ba49df-6bf0-4043-a8a7-4ed24556514b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11327","original_object":"UniProtKB:P0DTC2"}
{"id":"fcafcc6e-f7b6-4d11-ba1e-182b97f179fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136666","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:b6258134-ad27-41b9-a50d-9142b19eb9fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13862","original_object":"UniProtKB:Q16678"}
{"id":"b7d332ba-a8de-40e1-ab68-7a2c83cdc308","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8S5G34WY1","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:183a01dd-a4bc-4a6b-b03e-8cab16d0c574","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11024","original_object":"UniProtKB:P33766"}
{"id":"970c6fd2-1778-4c9b-bcf3-92b7c24b371c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IAN358A69K","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:cdd9271e-f379-4adb-80a5-622ee9619bee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8041","original_object":"UniProtKB:Q13315"}
{"id":"d2e356b9-6e5d-4a6f-80e3-6921ff985532","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:8af2261c-738e-42b7-89ae-9509a2729002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P28221"}
{"id":"f26d20d9-c4e3-4582-8117-64785497fd6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45293","predicate":"biolink:affects","object":"NCBIGene:31","sources":[{"id":"urn:uuid:b6420e35-9589-4b29-8fbc-4dc5399f6638","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12243","original_object":"UniProtKB:Q13085"}
{"id":"57256445-ffa8-4162-9c69-0d2312974af9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86H6B395PI","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:52d2870e-cbb2-465e-8b48-32755aaca253","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1218","original_object":"UniProtKB:Q9Y5N1"}
{"id":"7faadd3f-bf87-4e14-83d3-7cf53d9414cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2PHK27IP3B","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:66624855-05b5-4e14-a0a3-349fee418d51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13315","original_object":"UniProtKB:P43220"}
{"id":"1464f6a9-1a22-4005-9ec9-6e821075d288","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:753","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:8f858ebd-a393-4f8a-9721-62319e3c25ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:753","original_object":"UniProtKB:P32246"}
{"id":"1781d53d-e4e5-4a12-9f2a-7e329646bb05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1191","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:a3ab1492-e091-4719-8643-3fa2538c4725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1191","original_object":"UniProtKB:P30968"}
{"id":"b3c3b59f-417c-4ce6-b5cd-746749421f73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GNW87JO5PF","predicate":"biolink:affects","object":"NCBIGene:58959","sources":[{"id":"urn:uuid:f06d7941-d174-47cd-9e14-2a3430f0bb68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10377","original_object":"UniProtKB:P35353"}
{"id":"bcb7e8b0-728a-477d-951e-090405f6d9bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64227","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:7576bbce-7e2a-499c-af32-e2f80f01a1f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2711","original_object":"UniProtKB:P37231"}
{"id":"c89c5904-e079-4fe8-8b03-e3bbc3a3df48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZK5NA2M82J","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:f54543f2-9c6b-472f-86f6-be35267103c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4299","original_object":"UniProtKB:P14867"}
{"id":"455ae1d8-c084-45e4-9196-ab8cf922ba2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:d5961a05-a355-4045-8727-0cd6fcf6c173","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P20309"}
{"id":"338f74dc-f13b-4adc-9612-50fc5216e7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53377584","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:968a3d0a-30f6-4c2f-8d85-93e1209180b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13406","original_object":"UniProtKB:Q8R455"}
{"id":"209e3921-9e6e-4dd5-98a7-fcc05d137cf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393293","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:4e2c7ecf-fe0c-457b-87c2-ca5d86b1fd37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10401","original_object":"UniProtKB:Q9Y572"}
{"id":"5a837e80-2c67-41b6-bf20-f95a69f4192a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:642","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:ba3c7591-82a0-4f4f-82f7-7722a1b3e650","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:642","original_object":"UniProtKB:P46663"}
{"id":"63084d84-1772-4efd-906e-a71cdd237479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:e1fae4af-3e84-4ddf-b306-81c436941b5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P36888"}
{"id":"5e2dca66-ec94-4747-acac-82a7df3f1704","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230523","predicate":"biolink:affects","object":"NCBIGene:2571","sources":[{"id":"urn:uuid:3ba994d1-c424-4354-a3cd-db4db81b7063","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5267","original_object":"UniProtKB:Q99259"}
{"id":"ba265218-aad7-44bc-838a-24f8f99018dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56593349","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:ba56ecbe-df30-4a1c-a239-659ea132e294","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8322","original_object":"UniProtKB:Q9HBX9"}
{"id":"03f54e16-17f1-44f0-a228-6f2fdd6d7f7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9B0H171MJ","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:b027ba43-95a7-4174-be6f-4ab19e74c496","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9785","original_object":"UniProtKB:P22607"}
{"id":"ea8d4acc-0003-4362-8e02-215db9838dde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:5311","sources":[{"id":"urn:uuid:b26c57cd-c836-417d-a016-3372301f6e83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q13563"}
{"id":"6d05c121-d81f-4a0f-be74-2b7b5c449f65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:a10c5770-bf24-449b-a1d2-8ce239643c03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:P05129"}
{"id":"bd1cf6fa-ccdc-481b-9f81-899d4f9ad36b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23056","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:036db0e0-ca2d-41d6-8921-d6c956e3bf9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:318","original_object":"UniProtKB:P11229"}
{"id":"5ffe30cc-b63c-4ec0-b95c-d02c6809047e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132937","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:51a1b9cd-fc22-4878-a903-2c89e2ec1338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1253","original_object":"UniProtKB:Q9Y5N1"}
{"id":"b67d1d69-d995-4781-8fe3-5e2aadfe4b0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28502","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:f572e766-bf8e-40d0-ab9f-950ff209a847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7310","original_object":"UniProtKB:P08913"}
{"id":"1a9b8639-3bf4-44ad-92be-41e3eabfb718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50138","predicate":"biolink:affects","object":"NCBIGene:25874","sources":[{"id":"urn:uuid:0337be69-cad3-401a-ab68-b1cf88398632","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12601","original_object":"UniProtKB:O95563"}
{"id":"5a10689b-27a8-49d0-9820-c715c66bc447","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:40","sources":[{"id":"urn:uuid:c4a8ab13-9c64-4b02-9feb-57e3d7369d39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q16515"}
{"id":"64d61600-5e29-4de3-94b3-5f04abed4843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:bb900ab6-47d7-4bcc-bc63-a30085533a41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P28221"}
{"id":"06940170-b34f-4bc1-ad6f-ee44bcae46b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194548","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:bab11deb-5ec0-4f5c-9338-8c73bd5f1d40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:509","original_object":"UniProtKB:P25962"}
{"id":"e894241b-8681-45f8-a521-fe1668ce52f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13305","predicate":"biolink:affects","object":"NCBIGene:608","sources":[{"id":"urn:uuid:1cb1ee45-cbb1-4a56-810f-6ceb4ca24453","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13305","original_object":"UniProtKB:Q02223"}
{"id":"1c3bd2d5-49cb-43fe-be09-238064cf49de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:972680a0-a9ed-40e1-9607-421cef3868e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P08909"}
{"id":"fb47b30e-d926-467a-ba35-8c278b1b1ab6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ND1SOF0DLU","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:844720c2-1f9f-45ee-8756-98189729f6f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11412","original_object":"UniProtKB:P49841"}
{"id":"dbcc2e41-f0fa-42b2-bcb4-e9d21acb6f96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023895","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:7f1dbe5d-9f63-4788-bb59-e366b179e019","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3197","original_object":"UniProtKB:O95749"}
{"id":"90f260d8-e34f-4fb8-ae10-44107e488433","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:5c24d8fa-5f37-40b4-85b1-8d1a4c170f61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P50406"}
{"id":"9de186ca-3bcb-48b9-93a3-07e9798a1b66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76283388","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4f01e0d8-11eb-4d33-b95f-3e5c1d22ad93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13442","original_object":"UniProtKB:P28223"}
{"id":"a5284b23-5fc3-460b-a7a3-f5092891648a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231615","predicate":"biolink:affects","object":"NCBIGene:6788","sources":[{"id":"urn:uuid:44251b85-bb58-4726-9f3e-1c02e0c846ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11812","original_object":"UniProtKB:Q13188"}
{"id":"a98baa01-0418-4a9b-b242-f8643ae254c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:d55564b9-df19-40b7-ba3e-aad1e029c60d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P32304"}
{"id":"4e572feb-93dc-4722-8a39-65338f072fec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135351","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a79588fc-71d0-431d-874f-4b33c0c981b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:941","original_object":"UniProtKB:P14416"}
{"id":"0e8d18ae-cd48-47d2-916a-fbebf09f7945","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49836087","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:add4dc54-8bbc-4d21-8aec-3cde3f3d0253","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6222","original_object":"UniProtKB:Q14416"}
{"id":"6f17ec49-d5b3-419c-9489-b23c47b3fd8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3E93IV1U45","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:d6659415-5f6c-417c-9981-7a7da351fa15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3949","original_object":"UniProtKB:P14416"}
{"id":"ef2feabc-b5a1-4888-a0af-8568ec66e08b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ULD9ZKE457","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:db2190e8-5415-49ae-a415-0598d0808315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3516","original_object":"UniProtKB:Q9UKP6"}
{"id":"93bb984e-e320-45ef-a7bc-575305bbe793","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134991","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:3f66cbb4-03e8-45ed-98db-bef01594b254","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7191","original_object":"UniProtKB:P08908"}
{"id":"d25685da-ec28-4835-a6f8-479b44d45e23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13789","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:4fd1417b-c49e-4766-a732-9337302338b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13789","original_object":"UniProtKB:Q15116"}
{"id":"285b413a-892f-4951-a324-e7a09158b4e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65347","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:f6634cca-21a7-4f95-8b6d-c7b372621485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7420","original_object":"UniProtKB:P28074"}
{"id":"d0ab5c22-73fd-4d91-a9ec-6536efae616d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1112","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:2d564213-35d5-41ad-9002-112921c7be55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1112","original_object":"UniProtKB:Q02644"}
{"id":"3ca4656d-101b-4d9e-bb7d-8aaf5e2d5eef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9891167","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:f9bf4a24-9191-46a7-ba63-9f45f4c15192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:491","original_object":"UniProtKB:P35368"}
{"id":"829a5d8a-fe7d-4350-b94b-4f749e40ce99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D65H9YE9VU","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:5c0378c4-059e-4de1-be2e-c9dcdac4dee8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8985","original_object":"UniProtKB:Q9H3N8"}
{"id":"0ff58165-c126-4339-8ad1-72f5a4ab5ea8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:2aec7ec9-373c-4946-862f-7b7322a6c872","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:Q16445"}
{"id":"e6947a24-b7cb-4d87-b877-1b858db10e79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6935","predicate":"biolink:affects","object":"NCBIGene:8972","sources":[{"id":"urn:uuid:87f27d0f-7d8c-4073-a063-c2092960764c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4842","original_object":"UniProtKB:O43451"}
{"id":"0c3eb59e-b1e9-4001-aac4-8825e5101152","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60325","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:42ff6a8f-9646-4989-9a60-ef4afe32294d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8057","original_object":"UniProtKB:Q13164"}
{"id":"5e9e83a3-2888-46d8-9463-9a142b9779fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47782","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:8a604793-05f4-417f-80bc-7a3c18dee3f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7551","original_object":"UniProtKB:P23975"}
{"id":"988c3579-ff64-4c10-bc59-3bb4b9b0dfd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15335","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:11490280-2727-4970-add4-11da529c4899","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13776","original_object":"UniProtKB:P04798"}
{"id":"1a2e0d3b-3f62-4837-bbde-608e7943efd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:a094b611-e337-4581-999d-d88be875013e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:Q9NRM7"}
{"id":"7c128591-3f6a-47d0-90e3-42b2cc2f853c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:5567","sources":[{"id":"urn:uuid:dbcafc18-69d0-499d-a191-944421e2660e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:P22694"}
{"id":"11a6a137-cb5c-41df-a3a9-7fb7e463c298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H32ABL87X4","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:547e48cf-925b-425b-9a39-241cba60564a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2673","original_object":"UniProtKB:Q07869"}
{"id":"83bffd15-89bf-450e-8b22-93c92e5f373e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2248572","predicate":"biolink:affects","object":"NCBIGene:23408","sources":[{"id":"urn:uuid:5073d316-230e-4e06-bafa-d64c927cea6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8823","original_object":"UniProtKB:Q9NXA8"}
{"id":"182cbb4b-8164-4ee8-b24f-0ab56f60dd29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164852436","predicate":"biolink:affects","object":"NCBIGene:8463","sources":[{"id":"urn:uuid:deaa4241-caa2-4fc7-9285-d064766cbf28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12814","original_object":"UniProtKB:Q15562"}
{"id":"85dc85ac-d30d-43c4-a0cb-9beaeab54821","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5109","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:08caccd3-f08e-46f1-a5ea-b17d3b5cc288","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7078","original_object":"UniProtKB:P04150"}
{"id":"f6c7eb04-c54c-48f6-a471-7ea42fd2afa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229970","predicate":"biolink:affects","object":"NCBIGene:1786","sources":[{"id":"urn:uuid:45f8f655-7fc6-4f54-9f84-9c80292ebc9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13289","original_object":"UniProtKB:P26358"}
{"id":"5e8f6b27-2c73-46e1-bb82-4811b3a418bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44237094","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:a0714929-a780-4ad1-ab6d-b0baf7fac166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8055","original_object":"UniProtKB:Q13627"}
{"id":"a7dad80e-02b2-42cc-b8f0-b7c8a35b8919","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1282","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:8fa4b525-00f0-405b-89ce-70461afa6df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1282","original_object":"UniProtKB:Q969F8"}
{"id":"f83f1aee-19bf-4df3-8825-5bfaaf01854a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827340","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:268b3900-a751-46ca-a788-94d78feeb066","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:527","original_object":"UniProtKB:P18089"}
{"id":"ea3350ce-23c7-4b24-b32b-07ee63b7967d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176744","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:f98d4a67-f3b5-4e5e-a6b0-ecb859ae4bb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1925","original_object":"UniProtKB:P34980"}
{"id":"015dc42f-aae4-42ff-bc43-df783e334f19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:5a3c239b-186d-48d9-8e37-deb5e152ba7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P18825"}
{"id":"d77c3a5b-ef9d-47b5-8d5a-56e616d16e07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:8bee9155-5a6d-4314-b70a-db614599b39c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:P14867"}
{"id":"4da2214b-1866-486e-9b45-bb8dd9fb6b64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358908","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:89217748-ec5d-4032-84bc-28749a8e7690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:344","original_object":"UniProtKB:P11229"}
{"id":"75cceede-b418-42a3-8395-843dfaa8cce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101064","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:54ff6529-551d-4fdb-b6db-fb8fc5f9a05e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6710","original_object":"UniProtKB:P48449"}
{"id":"16b050fd-6e73-4c5f-800d-024a78417a89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:9d70f87c-6ca1-4389-8cf6-02dc368bfd00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:Q91ZY2"}
{"id":"ee556a25-a3f7-4c2c-ab9c-8b0ec601f111","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:125111","sources":[{"id":"urn:uuid:9923f2f1-72a1-4554-8319-23e0734bcfb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q8N144"}
{"id":"7f0ded11-5293-46a1-98a7-c84862dfd5a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:5a484c7c-7d0b-4e2d-ae4e-b2808306ca50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:P04775"}
{"id":"62f13c3a-d618-42c5-8614-cb31868e72ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135652","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:22912f91-b169-40c4-ad4e-fd6b150197d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12488","original_object":"UniProtKB:Q9P0X4"}
{"id":"706109b8-966d-40d3-8deb-14741eedf1d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138696916","predicate":"biolink:affects","object":"NCBIGene:54625","sources":[{"id":"urn:uuid:3538590f-a50f-4914-a77e-4550fb30e355","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13124","original_object":"UniProtKB:Q460N5"}
{"id":"9b965fa5-c63f-4a3e-a610-c9bdf5300f37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91936970","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:4400ce6e-4ec3-4a03-9e3e-47978c9294f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9989","original_object":"UniProtKB:P45983"}
{"id":"cb11067b-f18a-4fe0-80eb-c37ee047f276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25013811","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:4726b479-40a9-4c9e-8cef-c612ae92ea1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11780","original_object":"UniProtKB:P04150"}
{"id":"e2346606-9bab-4e85-bcc8-1968dceabd59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9870500","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:b6febac9-5876-43fb-92fa-928c784a2cbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:75","original_object":"UniProtKB:P28221"}
{"id":"4db78413-06a1-4304-9904-2460399d7c68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71461150","predicate":"biolink:affects","object":"NCBIGene:1452","sources":[{"id":"urn:uuid:05d27d50-62d3-4731-8702-31a125f9805f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8154","original_object":"UniProtKB:P48729"}
{"id":"e2b3637b-add0-4536-8f36-7afbb26795b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:5bebe11c-cdd6-449c-b768-dff21dacc7a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q13546"}
{"id":"4069ae2c-cd75-4870-aa48-a0e326d1d5a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139349","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:e60cf097-8617-4b25-90ca-9bbe4b25ffb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2443","original_object":"UniProtKB:O94759"}
{"id":"b381cec3-0c78-4ae1-8d20-826bc4ebdf83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:347732","sources":[{"id":"urn:uuid:83c15268-7dde-477c-addc-d4d02fa9bca6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q86XQ3"}
{"id":"b88643f1-684d-4e31-910c-9aa7460230b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8982","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:a0084b87-63f8-466f-a5f1-804721593cd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8982","original_object":"UniProtKB:Q9H3N8"}
{"id":"fd81f3c5-7a28-46bc-aeee-d87f349bc358","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699437","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:ba6da080-9a57-4312-b7ff-758f6ee684ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7648","original_object":"UniProtKB:P10721"}
{"id":"11010a67-9f85-4286-bf86-0bd14de38fe6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:2ae5b294-bedc-4c5e-ab58-283b9297b0a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:Q9Z2J6"}
{"id":"3b9ad910-df02-402d-8eef-4e98c319bddd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QX6O64GP40","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:46138e30-cf62-4df6-a862-9fd6ceded7c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11992","original_object":"UniProtKB:P10275"}
{"id":"38b7240e-7781-45e6-a8e4-b58e6265f694","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11964458","predicate":"biolink:affects","object":"NCBIGene:1135","sources":[{"id":"urn:uuid:10b6c484-1c08-418e-87f3-b7417e81b2ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3992","original_object":"UniProtKB:Q15822"}
{"id":"664fd91a-2183-4204-a1d9-e6d20e4fcc37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175901","predicate":"biolink:affects","object":"NCBIGene:6240","sources":[{"id":"urn:uuid:ebb9c7a4-1c81-4e6e-9516-c041a1bd05d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4793","original_object":"UniProtKB:P23921"}
{"id":"9b799bff-0c57-4ee2-b320-f436f2e7f26a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:663bc7d7-b671-4a3f-8564-a07a3d7c05ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2181","original_object":"UniProtKB:P47901"}
{"id":"84624e5c-efef-4eed-b624-af5134fa0392","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71967","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:574c164a-eeb3-4b7a-ae61-4bacde9d443f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7951","original_object":"UniProtKB:P48736"}
{"id":"a3947326-55a3-4bdc-86a8-c264269593ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086114","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:26e723c4-c5c9-4445-bb46-1c550844c7ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1618","original_object":"UniProtKB:P35372"}
{"id":"55413e21-c450-437a-a030-7a58cdb25a2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:251408","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:89b3a359-b8b4-49e1-8ec8-dabfae15c11a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9073","original_object":"UniProtKB:P22303"}
{"id":"e194f24f-fe34-4e87-abb9-79d4568a3212","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:836eecc9-2d3a-45f5-9f1d-d047067b503b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P28222"}
{"id":"31c1c049-e104-46ac-8762-8dc3c50dc2b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5643","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:5f32d504-d079-487d-85ba-ca58094728e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5643","original_object":"UniProtKB:P30874"}
{"id":"92fc1173-2fbf-40ec-ab37-6bcb725b601e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49843508","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:08e297a2-11c7-4483-8a72-ad47eafc718d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6657","original_object":"UniProtKB:P55085"}
{"id":"06b44df7-0d7f-410e-8dfb-5d917c92b33f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44370654","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:4087d9a0-73fe-4f2c-86e8-554aff15300e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3132","original_object":"UniProtKB:Q02769"}
{"id":"260dbeee-b2e2-4fc6-bd69-fa3f53ceb5f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44430609","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:8327e56f-d919-495d-8570-38a7e8abb503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3917","original_object":"UniProtKB:P41146"}
{"id":"63eccc41-0b8f-4981-b156-e4b8df1a64cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311330","predicate":"biolink:affects","object":"NCBIGene:157855","sources":[{"id":"urn:uuid:c2503993-1080-4540-af81-1320537fcea4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4271","original_object":"UniProtKB:A8MYU2"}
{"id":"4360816f-9060-4e96-8f95-a9905c59b921","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6534740","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:5225a25d-21e0-4f28-9f1f-0783d7872c99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10373","original_object":"UniProtKB:P18031"}
{"id":"e1b1178f-ec20-4985-b876-5809f910cd0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138752609","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:f061ad0d-2f1f-4178-adee-9c05ef358726","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11587","original_object":"UniProtKB:P61073"}
{"id":"9a3424c9-5107-414a-96d7-116696e21523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3167869","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:f31932f5-92ba-4a05-bccc-283d46b84005","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5517","original_object":"UniProtKB:Q13304"}
{"id":"0b6917c6-89af-47fb-89d5-0d67d7211cba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:3420d667-52d5-47e0-9c3c-8be990c6fefe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q8NER1"}
{"id":"ff9a9e9f-4358-41aa-9780-677663b8ca8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129786","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:d3f9a039-d0cf-4fc1-9de9-7b27edde9969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3276","original_object":"UniProtKB:P10980"}
{"id":"86fbffff-015b-45ad-8d03-8501f63a162e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90478321","predicate":"biolink:affects","object":"NCBIGene:8322","sources":[{"id":"urn:uuid:2ad6b59e-2641-4cdf-8717-f0fb8299855b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10322","original_object":"UniProtKB:Q9ULV1"}
{"id":"aac6a154-813f-4335-9494-df4be625b4dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6979053","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:e951a666-3efe-4a10-9441-902ed96f4bd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:288","original_object":"UniProtKB:P11229"}
{"id":"534d4049-d65c-4c82-80b0-6ba3684bb69a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4358","predicate":"biolink:affects","object":"NCBIGene:57007","sources":[{"id":"urn:uuid:dd01646a-7076-45f1-8a20-c8d4aa49c943","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4358","original_object":"UniProtKB:P25106"}
{"id":"96a20fcc-cfc9-471c-9435-fdbc001e60d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:3a616ca5-68ef-4b16-aff5-3efd3eac4b44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P34969"}
{"id":"b5e59d62-0307-4ebe-bb6d-d868f6dc97b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2882724","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:99d7df18-763f-4c84-95f7-63bf21062abe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3259","original_object":"UniProtKB:P11229"}
{"id":"45d5b715-4a13-4250-87a4-7c41d9259c71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:b994c971-e050-4a00-991c-f55c17b60ff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P28335"}
{"id":"615a0837-4da8-4ff1-945b-2e9a379333d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755157","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:2d3bb42b-66f7-4d8a-9ebd-04f3bca9b010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5806","original_object":"UniProtKB:P47900"}
{"id":"447a3dcd-37f1-4863-a900-4817a5b7b58b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:5a9d227a-7eed-43b4-b335-8a0f9f926f85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P30939"}
{"id":"cb61e34a-15f9-48a9-b642-36fff505ab98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:852adf50-de6c-4d0e-8ffe-46190f8d463d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:O15379"}
{"id":"1eed2bcb-5a54-4520-8707-9eabe46c477f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:5316ee4e-3486-4444-9bfc-a4a0fe585afa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P35916"}
{"id":"4b2c1ba5-bd1e-4261-be8b-9b71a3cbb067","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:57623","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:00139381-cee7-4e93-b790-202ada7238ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3049","original_object":"UniProtKB:Q03426"}
{"id":"a51071a6-2744-4409-8ff7-e0a1c1b8d759","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817521","predicate":"biolink:affects","object":"NCBIGene:140795","sources":[{"id":"urn:uuid:59b69af3-5fef-4633-838c-6af8c8a6e023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11453","original_object":"UniProtKB:Q9ESG6"}
{"id":"68f8e0a4-27a6-4e97-bad6-b30b9a8948ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611892","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:58af2cea-762a-4897-b884-210a05cb5885","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9992","original_object":"UniProtKB:P29597"}
{"id":"2f42efd4-7b87-4e4b-91d3-291007ad4876","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GGK40O1O85","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:36353bd5-3fc0-41dc-8dec-65840eb74ddf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9812","original_object":"UniProtKB:P06401"}
{"id":"e4da980c-322a-4a3e-abb5-48999162bc5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q0OZ0D9223","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:f858f7a6-378a-4c3e-b844-d26f3d966882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2777","original_object":"UniProtKB:P11473"}
{"id":"0f32de82-37a9-4f7f-93ef-eed59c4357f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130933","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:037040cf-0ee4-41b4-bbdf-86a618d45061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3886","original_object":"UniProtKB:P24530"}
{"id":"72916345-7f5f-4842-9b25-9ea996ec3ea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:e5ee14b8-c68a-4434-82e4-4dee4cf3a0d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P32745"}
{"id":"88749d7e-3ee5-495c-9f16-96ddcf780a2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2758","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:9474004e-9d63-4b24-b4de-d6088125bc7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2464","original_object":"UniProtKB:Q8R455"}
{"id":"ff6407fd-320a-4d5f-9632-2dcf41e678ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76649","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:6b1da401-ed04-4202-bdda-60b712ac5af7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:925","original_object":"UniProtKB:Q13324"}
{"id":"30279d25-8c0c-4cc5-92f2-da9364daf4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16761","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:6e3844b0-e236-4f7c-b924-47f8e34b8972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1712","original_object":"UniProtKB:P47900"}
{"id":"3f2bf695-ea7c-46a8-ad65-755dd15921ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O937X0Z5EM","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:b9ba24a0-4b43-46c6-95c2-da3add5aa6e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2689","original_object":"UniProtKB:Q03181"}
{"id":"eebcebb3-93ae-4ed0-b262-cca53771a751","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15042086","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:710503c6-84fe-4964-9399-aac43b223cbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9795","original_object":"UniProtKB:Q9NR97"}
{"id":"6f0c81f9-513f-4519-92d5-c05ce53f78f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:194328","predicate":"biolink:affects","object":"NCBIGene:1369","sources":[{"id":"urn:uuid:62680930-22ef-45ec-b5f4-80cd44bffd60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8656","original_object":"UniProtKB:P15169"}
{"id":"e57df77e-8268-425d-b8db-259202b71c24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:721809WQCP","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:6274e015-7adf-452e-98a7-080f7d85d82d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5263","original_object":"UniProtKB:P17252"}
{"id":"b7736132-e769-4663-9372-e498eacbcde0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3165","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:07649e5a-13be-4948-a66e-e60819c6c097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:649","original_object":"UniProtKB:Q61125"}
{"id":"ee0da5e2-d41c-40a1-9ad5-d551cee290a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6852176","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:a9160252-03fa-4a6f-81a7-3b6489c858b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8908","original_object":"UniProtKB:P03372"}
{"id":"62385f0b-0881-49ab-b5ab-5d7c00895d90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2272","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:95ee88be-8bd8-40ab-b772-a2acfc2ff24e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2272","original_object":"UniProtKB:P32241"}
{"id":"b73e3ffa-0701-4fd5-aa6b-e06bad612376","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8544","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:edd0cf0f-11d7-4a21-87e3-3e93fc57f417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8544","original_object":"UniProtKB:P43220"}
{"id":"9bda6919-006e-4bd8-9a26-3a82856cfbda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6104","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:55f5b939-e9ff-48b0-8c02-a04eba06085a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6104","original_object":"UniProtKB:O43603"}
{"id":"00bcc37e-0e70-4e7b-8e1c-23f63aefe781","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75124304","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:e297b499-ebe2-4305-9c00-c4addd191bb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7521","original_object":"UniProtKB:P25440"}
{"id":"c66e6a08-a095-4d3d-abfa-915c26379605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:65846726-ecc8-4917-9ba1-58bcf94188df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P31388"}
{"id":"16d2b15f-80f1-4edd-a89d-e0eb74e17fcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130930","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:60847f1c-5c5e-47bc-aed3-986587b96542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1172","original_object":"UniProtKB:P30968"}
{"id":"c430301b-3228-4db3-9c71-36c1bea3cbfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134812690","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:84d3c961-81f4-4a7f-8426-d521c0c30092","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11119","original_object":"UniProtKB:Q9UBN7"}
{"id":"6788ab36-e52e-4376-a537-a25ad9cb5e4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232302","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:b5057421-d2e8-4306-a0b3-ebda31fce51e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13112","original_object":"UniProtKB:P34913"}
{"id":"3cf6091b-d7e5-421d-9159-fe566654e13b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172845","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:446be400-6225-422e-b300-623c16cd2796","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1026","original_object":"UniProtKB:P33766"}
{"id":"c4455e87-28c1-4b7b-8da2-cb1c0939abab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCG5PW623C","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:51c75c3a-c874-4201-84d2-0197095d5a4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10170","original_object":"UniProtKB:Q9Z2J6"}
{"id":"245fab3d-2bc0-44c9-b8e2-f6cb426af540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:a7f10ebf-b139-4487-b8fa-bbf851b432d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:Q92633"}
{"id":"9ba5dc53-3c02-4f10-a08c-be372ec2b8de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12942","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:4946bad7-ba26-42dc-9d8c-1f50ef5d641f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12942","original_object":"UniProtKB:Q6V1X1"}
{"id":"d4fbc4ef-be78-4a6a-8131-cb8b2f869ccc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KL2Z2TLF01","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:0340caa5-900e-448d-9665-6c36e1dd0902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5933","original_object":"UniProtKB:P23458"}
{"id":"22fbd5a2-d3b4-4c9e-abbe-616aa7162ed5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:389de484-71e9-4844-b4d9-09c670f12a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:P51451"}
{"id":"e97bf927-0d47-4c55-88c7-8b6c34db9440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7W3V82OQ0P","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:69d3ed55-2c03-4f9b-bd99-385c04b4f663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8250","original_object":"UniProtKB:P07333"}
{"id":"17e3c059-8b26-42de-88de-2ad80c45fa8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:3ddee317-304b-4bc4-bcf9-e5ca2bfa7b10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:P56524"}
{"id":"d3eab2b4-0f01-493f-8fe7-6c99dff9c4c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:4191e21a-4e14-42f7-be49-a8edf73e4158","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:P04775"}
{"id":"d6883463-4cac-4f58-94d3-fa1e89bff0b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:6416","sources":[{"id":"urn:uuid:4531e75a-bc97-412a-ad8f-f455db6f9821","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P45985"}
{"id":"02172363-50a6-4f0f-8064-a46b44eb6034","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448634","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:0ae7d933-b101-4d14-9ab1-e2990be20232","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13741","original_object":"UniProtKB:P00533"}
{"id":"d37fe4fe-d176-4a7e-9eb0-8d3305b9a909","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34306","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:0719686e-8637-4e5f-ac61-22322edc87ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4103","original_object":"UniProtKB:Q9Y210"}
{"id":"9357f240-218b-4d53-af4d-671451ee9f52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:120653","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:976b2fc1-9b11-4dcd-955e-733675de1c5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6401","original_object":"UniProtKB:Q8TDD5"}
{"id":"687f78bc-85f1-4652-a037-7437ac8ffecf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S0N1VEG94I","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:6a26e8f1-8fff-4bde-9d7b-3df42151cfd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11756","original_object":"UniProtKB:P56373"}
{"id":"867edcc0-5637-4865-9447-828e742b8364","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:34ZKU73FU3","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:15a6e429-8f31-4ec2-86e9-2d17331d5877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9061","original_object":"UniProtKB:P10275"}
{"id":"f81e4d95-90df-465a-a7f1-605e36ddff89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46927672","predicate":"biolink:affects","object":"NCBIGene:8648","sources":[{"id":"urn:uuid:500514a9-b3ac-4224-a46b-635f3142ac8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8783","original_object":"UniProtKB:Q15788"}
{"id":"52dc3ab5-9fb8-4761-989b-1979a40e8f35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10458325","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:5bddac98-d704-4615-a666-7816e342c48b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7944","original_object":"UniProtKB:P04626"}
{"id":"29608cb5-3d2f-414a-b285-32324c3eb102","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:ed45a2bb-10f4-4939-a371-6618048a2e15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:P13569"}
{"id":"4a29e49a-9651-4ded-b071-fce1ef3763f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:c4f3ed7a-5a68-480f-bb55-049726d5f8d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:P06493"}
{"id":"2c44ed7c-3431-42ba-9f0e-55775da86c12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126456406","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:9297feb9-94d1-474e-bbf7-a48613e57db9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11931","original_object":"UniProtKB:P30556"}
{"id":"aa52a979-eab0-433d-a0bc-9ed949a48f7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16167454","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:dae1bad4-b9f2-409a-a67b-05551d2d17d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1298","original_object":"UniProtKB:Q969V1"}
{"id":"17b83688-68c9-4cab-8462-d33a001c0ae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:227632","sources":[{"id":"urn:uuid:272f86e1-8579-4d2d-9bf5-ecfad129a552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q6ZPR4"}
{"id":"a5be6a1f-1348-4a79-a926-71723570aef5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6R5034F862","predicate":"biolink:affects","object":"NCBIGene:3635","sources":[{"id":"urn:uuid:12f1ca3a-bbf3-4733-8ea0-2005e82fddf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9249","original_object":"UniProtKB:Q92835"}
{"id":"c0e5ed80-dd25-4f6f-b82b-75d25302170f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230486","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:12b63d5b-0d05-45e6-9f28-c3950c85d6e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10467","original_object":"UniProtKB:P50613"}
{"id":"042c2456-90bb-42ed-acd2-5dd223255394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14849849","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:1aa47175-6fef-410d-ad56-880613420454","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3000","original_object":"UniProtKB:P04035"}
{"id":"abbc105b-e7c0-4ac5-bf4e-137c6bfd38fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393290","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:6929f560-3191-4de4-b688-172e5de5aec0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10388","original_object":"UniProtKB:P15056"}
{"id":"609763be-68dd-4ea9-92a3-8215831ec578","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7476","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:00e989f3-2fb0-412f-b15d-128f5349ca26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5230","original_object":"UniProtKB:P23219"}
{"id":"462aa91d-4f5c-4ab2-af11-ecb9af3e72ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27882","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:08d06c0d-cdf9-4a36-a8d5-df8fbbabcfd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2367","original_object":"UniProtKB:P07437"}
{"id":"06c6d31c-94f1-47c9-aff1-3723792c9a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:a0938fd1-1c52-4e5e-b822-18c1cb2f565e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:Q60614"}
{"id":"8f5e9dd1-e7a2-4bc2-b041-808983cc73bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S3F315JJXI","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:d5c0d69d-3e3e-42d1-9001-7457b75d652b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9667","original_object":"UniProtKB:Q9NWZ3"}
{"id":"fdb843d3-0fb8-45e8-b207-9749535d9195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165715979","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:43e7742b-d1dd-4375-b179-635e41d90226","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12543","original_object":"UniProtKB:Q8TDD5"}
{"id":"ba63ba8c-e933-4be8-8db7-1a82ef32228f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:81739","sources":[{"id":"urn:uuid:31275f06-f402-404d-802c-71205b9148fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P49654"}
{"id":"5a156416-a507-46d4-8853-94fbe1fa4df1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:4e2943a5-8493-4d6f-90f7-a4aaf57de0f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P50406"}
{"id":"656f32be-398b-454e-b38f-acff94d913c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:914","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:35eaae9e-6493-44d7-a343-e01a29df8f50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:914","original_object":"UniProtKB:P34998"}
{"id":"f56ba03a-d0dc-480b-b019-bafe5296c4fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3756","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:c9d29ead-0f87-4142-a045-a8c5f9ca9595","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6963","original_object":"UniProtKB:P47869"}
{"id":"41f0d42b-66bc-41a9-b424-60bd1d0dfd57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118720630","predicate":"biolink:affects","object":"NCBIGene:64167","sources":[{"id":"urn:uuid:08133d28-a36c-4e91-8e56-c5a2e1b941a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9682","original_object":"UniProtKB:Q6P179"}
{"id":"21ac759b-e517-49e4-8d21-fc6598cb8975","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:33e35ea7-4b60-4e51-8b04-01ce31066b47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:P29274"}
{"id":"4bc5f8f8-e896-47fd-9897-dfd8ad7055e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:51dcf2ff-b1b3-41f1-8fc2-fad2f1dcde21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:O43353"}
{"id":"efb5ae83-2b07-4261-96f5-813560b001c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0W79NDQ608","predicate":"biolink:affects","object":"NCBIGene:3818","sources":[{"id":"urn:uuid:a7ed2aa6-0593-4386-8d26-46a3a38982fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11754","original_object":"UniProtKB:P03952"}
{"id":"dfe97327-2c1b-4768-ba99-48877728c9b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78540","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:4f3450b8-be76-4702-9aee-c3a406238ced","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7372","original_object":"UniProtKB:P27815"}
{"id":"0a4501b7-14a9-4e0c-8ea7-356d3481cd05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DDF0L8606A","predicate":"biolink:affects","object":"NCBIGene:22933","sources":[{"id":"urn:uuid:83316623-7fd2-490b-a90b-d857fa24b96b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8099","original_object":"UniProtKB:Q8IXJ6"}
{"id":"ee181286-3eb1-4444-a5fa-50c1c8dd3af6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164904685","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:27a812ca-8a0d-4f1f-852d-460eb4ae7e8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12988","original_object":"UniProtKB:Q96LB1"}
{"id":"2038726a-2468-4c5b-8aa1-64d3fbed606c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:3c476de3-feb1-4964-8e13-1dbb125069da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:710","original_object":"UniProtKB:Q9NZQ8"}
{"id":"f472bce7-2adf-44c3-b3d7-a0d68c7afa70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0G7D0CQ88I","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:c0c6f0ca-3d98-4d34-b2f1-9795b8f20ee8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7721","original_object":"UniProtKB:Q9P0X4"}
{"id":"77c13662-c670-4dc4-82c8-82228f2a7968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679541","predicate":"biolink:affects","object":"NCBIGene:255231","sources":[{"id":"urn:uuid:62675a98-96f0-4cca-93f4-ae555bdb1715","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11861","original_object":"UniProtKB:Q8IZK6"}
{"id":"91a734f2-5a30-4f89-8247-ee5068e30e37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947041","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:4b315c87-563a-4469-9d6f-421e4adf1300","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3017","original_object":"UniProtKB:P51639"}
{"id":"58c7cf9c-4a1c-4686-983f-13c750d4e24c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918513","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:0d63d34b-f365-4826-92cf-4fa332e01347","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12","original_object":"UniProtKB:P50406"}
{"id":"264a3359-9b76-4aaa-9a7b-53cf0e508f21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2496","predicate":"biolink:affects","object":"NCBIGene:2861","sources":[{"id":"urn:uuid:89b2e49b-2325-45cb-a21e-6dd383c0ec5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2496","original_object":"UniProtKB:O15354"}
{"id":"01db3465-e454-4cd5-ab78-66d7765a1a65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:127534","sources":[{"id":"urn:uuid:3d6dbdd1-7ea8-4c61-93c8-77a172f73eab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q9NTQ9"}
{"id":"00ac471f-7b52-4375-bbbc-8a9c4c929b46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8980","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:e2a34ed2-8375-454a-9e19-528e9f5ef3d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:194","original_object":"UniProtKB:P28335"}
{"id":"180e9bc0-3b56-401d-8198-ceb74858f64f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:57369","sources":[{"id":"urn:uuid:d366c261-2ca1-400a-84a2-7767b6a6d1c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q9UKL4"}
{"id":"5ba485b4-766c-416e-a41e-0afdb0e43ff5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168069227","predicate":"biolink:affects","object":"NCBIGene:9730","sources":[{"id":"urn:uuid:982a5e0c-676a-4cd5-a2e0-cb2e17ecf48c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12815","original_object":"UniProtKB:Q9Y4B6"}
{"id":"5d822454-07f4-4136-9128-f6cac780501d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947515","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:8a88fe47-5bc1-47db-bff0-a96ca5969b6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9916","original_object":"UniProtKB:P48736"}
{"id":"ec0b461d-89d3-4cad-b00f-69506d1cf0a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121362450","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:505490d3-02e0-4c69-b1f0-117caa2c602b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12154","original_object":"UniProtKB:P05164"}
{"id":"4c44ec88-0ab2-493c-a074-e578efd692a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:63FJ7LF55O","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:5979e186-b1ee-4dba-be6f-4c01b95f4809","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12557","original_object":"UniProtKB:Q9HBA0"}
{"id":"1da9dfac-0405-449d-8a7d-26a17d523408","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:053c4f69-5525-4a39-8be9-4ce0d5d14e95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:Q00535"}
{"id":"0f4256b5-5214-472e-8782-6acc06046652","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6T8C155666","predicate":"biolink:affects","object":"NCBIGene:1493","sources":[{"id":"urn:uuid:5da9f90b-7c6d-4a46-abb6-e7a7a8db76a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6888","original_object":"UniProtKB:P16410"}
{"id":"2b0ddefa-05b2-4205-9e69-c65f83ac5f00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115107","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:8f0f13f8-eacc-4486-bea3-b1342e90874b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3298","original_object":"UniProtKB:P35462"}
{"id":"7b9ca5cc-4040-4fe4-9dc6-732baded9087","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y61S1UFN4Y","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:58a80b81-529b-4366-9ea8-5b5754a278cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13182","original_object":"UniProtKB:P18825"}
{"id":"f1b1930b-0232-4a57-95a4-e064878fb2c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:dc128e8d-2850-4e70-a74e-f1c01a86bccd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P34969"}
{"id":"2b8bcddf-ea36-4c1b-9b6f-05a4b1805e6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:7b6b67d1-10bc-42d6-9b24-7244f3c90205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:Q9Y5N1"}
{"id":"2b15f06c-1df4-4e5b-978c-834a905d31b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:c64c13f0-31f4-408d-97f6-2b5d541a0e9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:P23944"}
{"id":"35f06259-1439-4c60-87fe-17e123070d81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71543365","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:268aff65-45aa-46b4-8351-6ca828904fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8390","original_object":"UniProtKB:O60341"}
{"id":"1f0b2963-7454-47d4-8725-f492002e400c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4904","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:568a3408-5d8c-4e65-ada1-3ed24517e50b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2621","original_object":"UniProtKB:P04775"}
{"id":"52ce12e9-842d-43e3-8f72-3d080c4ab9f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95093","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:7cc0c49b-57e4-499f-9e85-2b4f77e9c5c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8974","original_object":"UniProtKB:P42336"}
{"id":"e18098d9-5f61-4044-bfd1-e0fb2aef413b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15780052","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:2acc7bbc-6274-44cc-afa7-d54e1cb5a353","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11930","original_object":"UniProtKB:P30556"}
{"id":"a96ec764-d84f-46c1-ba4e-ef980859e151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45483651","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:bb9f6ebb-2714-4fea-baca-816328c65bef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9193","original_object":"UniProtKB:P41143"}
{"id":"71e88c9a-c413-4048-8871-205eac23f701","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8923","predicate":"biolink:affects","object":"NCBIGene:84894","sources":[{"id":"urn:uuid:6e9c759a-55be-48da-b547-1e9370fbdbbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8923","original_object":"UniProtKB:Q96FE5"}
{"id":"f7661e2d-bc06-4a8d-9422-21491236394c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32184","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:5b9395d5-68c4-4eb0-aa7a-b2178c064c1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6952","original_object":"UniProtKB:P10276"}
{"id":"148c4f45-32b0-44e5-adf3-3f954c62f817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48861","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:c8b3fa23-5cb7-4301-9365-de325c359f79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3052","original_object":"UniProtKB:O95749"}
{"id":"25e9b489-185d-4544-86d4-b66130a8a3be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841284","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:5110dc6e-dea3-44f2-bce7-4c1a4221ab5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:423","original_object":"UniProtKB:P25099"}
{"id":"4367c06d-6e90-4113-bc03-6a248d9b3a27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:bf0bbcaa-c219-4416-a95a-b371e25fab76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P31388"}
{"id":"b0e93249-12af-4da5-8f75-c505790da363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46906168","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:d7e5b0ef-82f3-4728-973b-f27fdcb6efae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3023","original_object":"UniProtKB:P04035"}
{"id":"1e9da107-9e1a-4a46-bfe9-2a9084d89eab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1489","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:02405ede-4d22-495a-9e9f-c87867ef409f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1489","original_object":"UniProtKB:Q9Y5X5"}
{"id":"6b53baca-67a7-4fcf-86bb-240362e8b7e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47381","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:ac1a4d1b-eeff-4e42-9b01-8a10fbac88b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2714","original_object":"UniProtKB:Q7Z2H8"}
{"id":"8efbf5ab-a0da-410a-846d-e8cf0b10901c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YX55DXP4T1","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:b853cd24-8577-4359-a536-5038fd67dc5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9054","original_object":"UniProtKB:P09917"}
{"id":"6217002c-c63b-493f-94d7-40db083ce104","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2706","sources":[{"id":"urn:uuid:8bdaa316-0587-4d38-b37d-07c731b22436","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P29033"}
{"id":"e62eed55-ce0a-4dfe-a409-1aef6f28920e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WFG29AB872","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:ea8e4ab3-fe49-40e5-985e-7fbe31a024a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9928","original_object":"UniProtKB:P42336"}
{"id":"225c2f52-e024-417e-ac36-7bfbd540f12c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233305","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:f44e1cbb-92ba-4e62-a768-4d19bb758ae4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9368","original_object":"UniProtKB:Q86V86"}
{"id":"a0113f35-0e2d-4264-b08e-e1a93a5e16ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:661","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:89ed4b59-d7a6-4324-a604-2561d22320bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:661","original_object":"UniProtKB:P46663"}
{"id":"42c28c27-b4a8-4f92-8dde-1ca83d3d0a80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124959","predicate":"biolink:affects","object":"NCBIGene:4842","sources":[{"id":"urn:uuid:c4895211-5469-4abf-a57f-9c9a7aa0623a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11467","original_object":"UniProtKB:P29475"}
{"id":"caf349ca-4de1-4aa8-b116-965a7866358b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163410393","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:c08987e6-9162-438f-b8c1-b20eae4d6e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12057","original_object":"UniProtKB:P22894"}
{"id":"e257a33a-d4fe-46c6-a31f-031ed7fae1e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101244456","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:328ca734-a4a0-489c-bb32-bced97b840bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8604","original_object":"UniProtKB:P11229"}
{"id":"a9984087-389a-4255-ba7a-d91a721a7929","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RC2V4W0EYC","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:e547f3e6-a21a-4a53-80f9-8f5ffac5bb2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6918","original_object":"UniProtKB:P50052"}
{"id":"2c192f87-b76f-4956-935c-c4e0a15b6138","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:03abb637-34c5-4928-8073-ab6b2f0f45e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P32304"}
{"id":"7c117041-d011-4c8f-b498-6c4da8d1840d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:66f13f77-8c00-445e-ae93-7a4aecd542f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P36888"}
{"id":"691bc293-eeb3-434c-a44e-7eb75a020f87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12991","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:3aa07a81-140e-4932-b030-f3cb1baedabe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12991","original_object":"UniProtKB:Q15116"}
{"id":"b334a1a2-6c29-4789-bc62-594109b5cd54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:35C6UMO5SR","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:597c7c49-3404-4029-b484-6e96d2698f29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:101","original_object":"UniProtKB:P32305"}
{"id":"7d6bcbec-e475-41c1-a89c-cb33a3efbf94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:0b5f3cb6-7a46-41fc-9c98-3ae19787b00a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2330","original_object":"UniProtKB:Q12791"}
{"id":"38217d68-5313-4149-9750-3ddbf624a75c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6923","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:dbcadf71-1cff-4065-b558-dcc184a8163a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2449","original_object":"UniProtKB:Q9NQA5"}
{"id":"1c64381c-6d46-4ba0-b1a0-aea0fe82ee57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231087","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:28d91196-7711-4120-8918-1ed983a20aad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9626","original_object":"UniProtKB:P50750"}
{"id":"3d590632-f810-4e73-9af2-8506f4f87c26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93561","predicate":"biolink:affects","object":"NCBIGene:10392","sources":[{"id":"urn:uuid:5a81c9f7-646f-476b-8bf8-d55b4b53d3df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8887","original_object":"UniProtKB:Q9Y239"}
{"id":"ae4702e7-73de-46da-9df7-d983cea6d477","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:f8cb3093-6795-4b89-a46c-a1cbb903a753","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P18825"}
{"id":"e18271f8-0332-42cb-8653-1b0eb8c4557c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91433","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:492d5f94-02b2-45e8-b41c-8f37b6bb6e00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9383","original_object":"UniProtKB:P17948"}
{"id":"9a4b1dea-6a5a-4686-85ef-cc626da5b8db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437864","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:9c9524af-83fd-403f-bcc9-6929a4d62be3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2103","original_object":"UniProtKB:P25103"}
{"id":"d40743a9-7795-4358-8c02-7abe105f72af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LFR1253W75","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:3cb76af8-bb57-490b-9f4d-abe8bbb4bf36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5946","original_object":"UniProtKB:P06493"}
{"id":"8eb8875d-217d-4b59-b209-2da5a04dda47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131907","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:32949aa9-9d84-4b31-849d-f51dc03dbc91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:25","original_object":"UniProtKB:P08908"}
{"id":"897b5669-be33-4244-85ee-cd4f5ba1389b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2158","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:72fd671b-d12c-4987-86c1-baeea4928901","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2158","original_object":"UniProtKB:Q9UKP6"}
{"id":"00ab86c5-156e-4518-8f25-a04b0f1273c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146219790","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:2835df70-249d-4587-a076-046f9f4e54d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13485","original_object":"UniProtKB:Q00534"}
{"id":"39d2b6a8-70a6-43fe-b7ad-5284dd5d0510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10434","predicate":"biolink:affects","object":"NCBIGene:768","sources":[{"id":"urn:uuid:475c611c-5e60-4c26-adc8-7495a22170ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10434","original_object":"UniProtKB:Q16790"}
{"id":"9d5eef39-9daf-4511-beef-80695cbdf017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:759","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:9bb6637b-f1e3-46d4-b608-34c309d06309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:759","original_object":"UniProtKB:P32246"}
{"id":"7c6e3924-50be-4956-9d5b-a6c4e6c9203b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69808","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:f7c1f461-16b8-4ed8-92e7-4a17c7cec726","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13464","original_object":"UniProtKB:Q8NET8"}
{"id":"c2fe71c4-dfbb-4eb4-a80c-39eafa7252c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38895","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:40565544-bb37-40d7-8efb-37528c256a43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2368","original_object":"UniProtKB:P23416"}
{"id":"bf77a618-f628-4397-9ec8-9c387662caed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422749","predicate":"biolink:affects","object":"NCBIGene:57396","sources":[{"id":"urn:uuid:faebc58a-9207-4679-97fb-5dae6262377e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12975","original_object":"UniProtKB:Q9HAZ1"}
{"id":"8f13543c-fb77-435e-9d0e-c0dd3d2ee870","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:15a107bf-f17c-4eaa-89c8-2bacc4da8895","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30875"}
{"id":"3ab4fc47-7b59-4896-ac08-cb1328c05e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11305934","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:2e6e0b63-f733-48c7-b9b1-7e0dd24944b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1315","original_object":"UniProtKB:Q99705"}
{"id":"2ce2f210-515f-49b0-a34f-813bfb7df07d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:ee3db106-5284-4640-be37-eeaf024446ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P08908"}
{"id":"f275bfc4-ffcf-4c6d-888a-54403060862c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9344","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:ffad5542-0970-41b8-90c0-04859942859f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9344","original_object":"UniProtKB:P30968"}
{"id":"d655d780-deb8-4840-aa7c-11bc5ad4e0ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:544DR70TN4","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:398c43b1-14fd-4fb8-8ff3-57d083a4f6f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10178","original_object":"UniProtKB:P21554"}
{"id":"cd97a460-9a58-465d-a824-de9e84db300b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311230","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:eb3ed279-795b-47f4-8029-d9c87e1733bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1933","original_object":"UniProtKB:Q62053"}
{"id":"55ea57fa-8e69-4064-ab91-093683f0e6d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754995","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:e0b205d8-df99-490d-bbfd-3a3b37972a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:482","original_object":"UniProtKB:P35368"}
{"id":"40c64976-2c92-4d7a-a95a-a9037f513422","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13547416","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:f30e987e-5859-4ada-b2f1-a4a9f0056f67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:169","original_object":"UniProtKB:P08909"}
{"id":"9f83b0ad-16f9-4792-92c1-e9b7cc350a3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6075","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:4c9e9dc1-b9f7-4b2e-bda0-dc238a12af71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6075","original_object":"UniProtKB:O60755"}
{"id":"546b5fda-fc67-46ce-b0da-682486122ae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93641","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:aa151b35-e6f3-4dde-a6d8-7aea629b8dc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5924","original_object":"UniProtKB:P06493"}
{"id":"27a0fee6-4879-45e6-bb16-afa376c961bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6TGA89COP","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:ed0174b6-62d4-4032-8799-69af9c1ec7a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:211","original_object":"UniProtKB:P14842"}
{"id":"2a1bd8df-e94d-414a-8e0a-10eb23fbfe3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:12747","sources":[{"id":"urn:uuid:63868717-d0e6-4cdd-b918-401c666c66c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:P22518"}
{"id":"f15a4f65-e335-4329-b45b-98b3128e13a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AM9K4SZ3XK","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:31dca084-1d91-4655-97f9-20e1da7887c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12122","original_object":"UniProtKB:Q16539"}
{"id":"c496db2e-a66b-4e0d-ba7d-b6307f4c23ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:9487c67e-88e2-4112-b3a9-77208232f3f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P28221"}
{"id":"c8f938e7-9485-4e70-b61f-6bab6e7bbed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10872780","predicate":"biolink:affects","object":"NCBIGene:3635","sources":[{"id":"urn:uuid:f47065e8-8cb0-4335-8b35-2c97c47f5ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9564","original_object":"UniProtKB:Q92835"}
{"id":"303520db-f38e-4d47-b2e7-e1fecd5e74a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:a699956b-7f24-40a0-a40e-020e3937035e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:Q9UM73"}
{"id":"56a15d6d-3008-42e8-b56e-bb620eb411c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11998198","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:c60ee4a3-6e6e-4b72-80c4-e499ea24a9ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5732","original_object":"UniProtKB:Q15858"}
{"id":"779fe5ec-495c-4db3-90fa-d8c4ac4b2cd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:447196","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:4bb1d4d7-ffac-4e68-8985-342ae1f682ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4071","original_object":"UniProtKB:P39086"}
{"id":"2cbe7d43-fa34-47b9-9f56-6a88344ce9b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9843","predicate":"biolink:affects","object":"NCBIGene:54106","sources":[{"id":"urn:uuid:baa9e48b-9d0e-4b59-b89c-2746c1dc6393","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9843","original_object":"UniProtKB:Q9NR96"}
{"id":"a96fca8e-d633-48b0-875e-29da95cb5705","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:2882f83c-639f-477b-8906-e6c49292e710","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P30939"}
{"id":"ef203810-4957-4c2c-8a08-c303d72ad345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71611179","predicate":"biolink:affects","object":"NCBIGene:699","sources":[{"id":"urn:uuid:7e06a716-b1d9-4408-8f80-2bb9dade39d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9127","original_object":"UniProtKB:O43683"}
{"id":"465cc9e9-05db-4bc2-b10a-5c7cbfb30803","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137455315","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:81391bb8-e7b5-4a6b-822c-d96b208bb1c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11869","original_object":"UniProtKB:P07333"}
{"id":"5c0923e0-816e-4df7-850f-e0aac654649c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1B419P24AV","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:3eeec29a-66fb-4170-b305-0a2374e5e821","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1701","original_object":"UniProtKB:O43613"}
{"id":"b2fbc400-84d3-49a4-ad7e-2734af252db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17659","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:82481a85-87fa-4379-b9d9-ed4c4c82c4eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1749","original_object":"UniProtKB:Q15391"}
{"id":"a6177c07-65cc-4133-abbe-bd525264c292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J9HB2T5SS4","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:5b5d116d-a429-453a-a484-b79a8b9efd22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7660","original_object":"UniProtKB:Q12809"}
{"id":"2d505038-2540-4d6f-936c-50a72e0490d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:423738","predicate":"biolink:affects","object":"UniProtKB:A0A140DLX4","sources":[{"id":"urn:uuid:1436c5f5-da68-44f3-a579-b3d3176b7fdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9652","original_object":"UniProtKB:A0A140DLX4"}
{"id":"2ef85722-df23-42a5-bbf8-4d93d40118c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91465","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:5d67f13e-a469-4bb7-a8b2-ea11a0e86950","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8008","original_object":"UniProtKB:O14965"}
{"id":"84544220-56c5-454f-8390-cd615c24aa8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94504","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:f4143867-771e-4a83-9bb7-b988d2412c73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8464","original_object":"UniProtKB:Q9BY41"}
{"id":"4b8483d8-e453-4bf1-ac3a-e0659905db5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:22e99ce8-2765-4fa2-9fde-5a7f30e6d074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:P23415"}
{"id":"7de94521-39f9-466e-a148-4231a2a2c57d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:50ee267e-f6b2-455f-9421-f5b866eaa54c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q9BX84"}
{"id":"9bc9986c-eaf7-4a69-8de3-4d52bef1ca35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:60399","sources":[{"id":"urn:uuid:9cdce016-e0e1-4687-9864-cdc67c43a906","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q9JKM5"}
{"id":"1fc020dd-0f59-459d-90ea-84ae25d5ac27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82702","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:025dfc55-29c1-4d94-afee-3ac23c762d24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4047","original_object":"UniProtKB:P25116"}
{"id":"2ff53845-8547-486b-9989-ffa126b9c87e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34457","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:0da00b8a-f11d-4bc8-bc47-b10bb59bb7b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4270","original_object":"UniProtKB:O75762"}
{"id":"833cd47d-9c59-428a-810b-f17f366da7bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:5592","sources":[{"id":"urn:uuid:48322688-6c70-4b1b-a04e-17b6138f0064","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:Q13976"}
{"id":"11c58188-4e8a-46e4-a41d-ed42763d507f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13681","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:1e8c66a2-f815-4770-9355-e5b56d2a69a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13681","original_object":"UniProtKB:P31391"}
{"id":"093aacca-6256-4bad-ad9f-9c3c6611fff5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34461","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:50434fb3-0fee-429f-9b46-30c113d6c9fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4321","original_object":"UniProtKB:P34903"}
{"id":"57068ed9-de33-4990-8554-759a453ffa9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9940","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:3274d81e-fdf2-4f13-9c6d-47d56fe61377","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9940","original_object":"UniProtKB:P14902"}
{"id":"f6fbc6a9-b9a6-4c79-9274-5270dfb1bff4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16122555","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:1555dc18-ff50-458d-81d1-e747a54ce5e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7975","original_object":"UniProtKB:O95749"}
{"id":"7926f02c-d014-456a-89d0-744419937061","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11908","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:633b5614-d896-4f39-8c2e-7efe699fd1c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11908","original_object":"UniProtKB:Q9NSD7"}
{"id":"fa024318-0543-4aa2-9b33-1a45894148a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:249982","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:986bc31d-7842-433b-b3be-d510b7e7f3e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2518","original_object":"UniProtKB:Q13936"}
{"id":"92247e72-b8b0-4cb3-aeb6-de95f67da83a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:143f0f3b-c101-4d13-9bb8-280b5d7f04f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P21917"}
{"id":"1550edfc-f3d4-40d5-a694-8ece5709259f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2086","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:d35796c3-d206-46c8-beb3-bee9b1c901d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:145","original_object":"UniProtKB:P28335"}
{"id":"8c007661-614f-485a-aad4-df939f87eeea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1103","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:1d4f9ece-ea7a-46f5-8594-802fb06644cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1103","original_object":"UniProtKB:Q02644"}
{"id":"48ec136e-1dad-40eb-8801-1bb989454479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93773","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:00d30692-d97f-4215-a779-def1a6413cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9129","original_object":"UniProtKB:P04049"}
{"id":"cb18d6f0-5aed-4c6f-a904-746a72eab82d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:939U7C91AI","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:6115155c-ddab-4452-8f37-e8a5c092d2f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10342","original_object":"UniProtKB:P23975"}
{"id":"8779fe4a-9fd5-4895-bf9b-6c84815c4da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:142459303","predicate":"biolink:affects","object":"NCBIGene:9451","sources":[{"id":"urn:uuid:2b478eb5-9a64-4746-8650-d176968c2a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13275","original_object":"UniProtKB:Q9NZJ5"}
{"id":"92fe438c-2506-405c-a449-3dd3b12d0107","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K41YC3AEI8","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:01de0204-2967-49b7-b65b-a06562b4f4d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1622","original_object":"UniProtKB:P33534"}
{"id":"f0e6b20f-f1ec-4c9f-96db-0b56fda073d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:38d2e8fd-c7ed-4e0f-8c71-306fe856305d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P30939"}
{"id":"f68e806f-08f4-4ad4-a5ea-2f97aa3fed59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91194","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:7e251c56-8853-44fd-bdc5-820a137caf83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2907","original_object":"UniProtKB:Q9HBW0"}
{"id":"0ed45c58-0613-4edf-b426-ab87b434c4e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86294067","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:3bd247e5-f0d3-4710-92ac-64eb755487b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13682","original_object":"UniProtKB:P31391"}
{"id":"cf41a0a1-a767-4f9c-92cf-805bf2ae0075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:00678e9e-69de-47dc-9ef3-aa5cd9759adf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P41595"}
{"id":"782d5259-55cd-433e-8f6d-c289ec63a579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1154","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:3a769dd8-8067-41c3-8ee3-b9f07a4620cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1154","original_object":"UniProtKB:P23811"}
{"id":"eacbe89c-2cf7-470a-883b-69423167c0bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:768FW21J3L","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:a7a2b6f9-0f5c-4d70-81f0-380440f81742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7886","original_object":"UniProtKB:P09619"}
{"id":"2a414748-506c-4a8b-bf74-6368b8faa410","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827339","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:7caf1813-6a2c-4366-9cf6-3724e05d29d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:369","original_object":"UniProtKB:P29274"}
{"id":"ba80a3bc-16f2-45f7-80bf-34a3a132ed51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1529","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:a698a125-e542-4937-94c6-07e4d75c3d9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1529","original_object":"UniProtKB:Q63447"}
{"id":"f0b5fbad-6099-4ea8-8370-831ef16c2b3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125467","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:6b7a1f61-a8fb-4d2b-aed5-c272c6021cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1265","original_object":"UniProtKB:Q9Y5N1"}
{"id":"8f378815-fd0e-4bd4-8ac7-45e6f668df68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:297cc532-92b4-4269-a113-78c7c068691b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4192","original_object":"UniProtKB:P47869"}
{"id":"0692c4cd-5253-4e43-9a07-2a254fe61f2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51913","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:fac90112-4510-40f9-bf3f-d20a1ca914c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5973","original_object":"UniProtKB:P17252"}
{"id":"c7d0236b-9a50-4b2f-a02e-1386099a0c8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11951384","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:6b508852-d263-4bea-8f55-812c1254b016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6064","original_object":"UniProtKB:Q8TCW9"}
{"id":"2cebf8bb-cd29-4966-be7f-91d466a683d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71258968","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:20d4c288-589b-42cc-b888-d44e41d3f3bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12717","original_object":"UniProtKB:O60885"}
{"id":"6c438aea-4a5d-442b-8d37-1b9ba7f66396","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16727408","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:f279e746-84e7-4bfb-9f1b-14781f9c6730","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3968","original_object":"UniProtKB:P36544"}
{"id":"d80ed508-a91f-4ef8-a4f9-338b90ce3743","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9009","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:64760f7f-79d6-4383-9536-94f678fe7e1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13729","original_object":"UniProtKB:P27338"}
{"id":"b7c95012-af0f-4089-b4a5-3f4675d11b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71193","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:2e4e6400-499e-4e78-82ce-1a8c7ef95720","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1133","original_object":"UniProtKB:P43220"}
{"id":"e7d389fc-814e-4345-a80e-e8451d869e0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:200HA2LIMK","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:98592f11-e512-43cc-9dce-bb7500be606e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8173","original_object":"UniProtKB:Q12852"}
{"id":"d0c9c9c2-ed90-4967-b368-a76b8fa3e3a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:4c194e91-d028-422e-a180-44154a3afbb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:O15303"}
{"id":"d1f12b47-9ac7-48b5-8742-61c71269012f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69636646","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:393a30de-ef57-425f-9f57-fcd8ac611673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4246","original_object":"UniProtKB:Q13002"}
{"id":"ccad4bb2-686f-4306-af30-0d875106aa64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:632","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:7f3bf6cf-d77e-4240-b266-4ecc75a40531","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:632","original_object":"UniProtKB:P32247"}
{"id":"adb80ced-00ea-474c-8ea4-476182a4fc31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:5d039fcb-b34c-4cbf-8861-2e12e3b0f95a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P31421"}
{"id":"a650380b-13cd-422a-98a4-f74eb663b8ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56589615","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:ebefffe1-25fd-46a3-9d8d-418cc8b34bb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8875","original_object":"UniProtKB:O14684"}
{"id":"937ce1c8-34da-419c-a8e8-0f9e60e5269c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V4JYY6ESD3","predicate":"biolink:affects","object":"NCBIGene:5651","sources":[{"id":"urn:uuid:a704a3b5-7db7-4075-b5c0-891f8fb5b7ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11683","original_object":"UniProtKB:P98073"}
{"id":"0bc2e75a-493d-459b-9418-45fcbb9e6273","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:7c56f92f-cf7c-4ccc-9339-851963b87c60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:P56524"}
{"id":"827e15a7-5c8a-4c26-b855-3b36fddafc06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1512","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:cd0300ac-6398-4286-b56f-9b493a4ff1e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1512","original_object":"UniProtKB:Q61041"}
{"id":"4a09b88b-e0f3-44f7-acbe-bb886d539ac7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50838","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:40613d56-45f0-4960-8ab2-516c21f9c494","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2874","original_object":"UniProtKB:P08235"}
{"id":"22e81906-a33a-4bcb-9415-1a49feb623a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16755780","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:928ba040-e3bc-475a-8a52-0cd16287f8d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7711","original_object":"UniProtKB:P07333"}
{"id":"7dc17749-d5fd-4417-adc5-836e47567cd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25172871","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:d98b6396-0c2a-419f-9ef4-741f04007d30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7732","original_object":"UniProtKB:Q13490"}
{"id":"e8d4ed43-1dd9-49e2-a5ea-3d48a4392759","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135530","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:f3d9bf18-898e-487d-8c77-14a49ca607da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7483","original_object":"UniProtKB:P11229"}
{"id":"6577dd8d-e798-4ac4-89d3-0721bc4c9d3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70669253","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:8d7d8ac0-8526-41d7-b291-f886c606036b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11292","original_object":"UniProtKB:P41968"}
{"id":"ad96f695-3b3c-447c-af10-38ffec628987","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827377","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:9b6f2b6f-3e2e-49cb-a4e5-200cc2103ab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8598","original_object":"UniProtKB:P11229"}
{"id":"84025d43-cb0e-43ef-955d-c3a24e8eeaaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135348858","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:23b4909d-3270-4ed3-abe9-848402ccabe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10490","original_object":"UniProtKB:Q9BY41"}
{"id":"9de4bb1f-1ec2-44ca-b940-e075726de8a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6073","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:2a66a352-5d44-4e75-ac0b-1bc4a2f13864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4488","original_object":"UniProtKB:Q13936"}
{"id":"b78eee03-3108-4e54-93f9-392c1598a046","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947069","predicate":"biolink:affects","object":"NCBIGene:81727","sources":[{"id":"urn:uuid:3257bb37-d7ac-484d-8add-bd0c0f0d226b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3216","original_object":"UniProtKB:P17256"}
{"id":"025d413e-c9e5-494f-a768-664f079d5416","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41922","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:ee8e8119-ec4e-4d8d-bb49-a1069d733dcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2801","original_object":"UniProtKB:P62508"}
{"id":"dadbbbd7-3d7c-4045-a778-d4f42aa45ce5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17200","predicate":"biolink:affects","object":"NCBIGene:171108","sources":[{"id":"urn:uuid:38d39c11-eafc-4f11-9fee-5a3c1296132c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1784","original_object":"UniProtKB:O35881"}
{"id":"a7db9e71-6609-4e29-a1b2-93fea52e5e16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189651","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:897d9dce-522f-4396-bf0f-d3d5863e43a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10534","original_object":"UniProtKB:O60885"}
{"id":"91dc55f3-e0d3-4f79-8001-f6925b6c5e35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321937","predicate":"biolink:affects","object":"NCBIGene:1135","sources":[{"id":"urn:uuid:95cea1ae-f6c9-4397-ac64-f2ed93d73bce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3979","original_object":"UniProtKB:Q15822"}
{"id":"e8c0309f-7b59-479e-8deb-3084fa19d45b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50938551","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:45411661-23d3-4e3c-b35a-2f31ab825828","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7854","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"fa3e50b9-4398-480d-9069-20c900330681","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135351","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:7b0fda48-ad08-4aff-853e-aa94779c6d21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:941","original_object":"UniProtKB:P21917"}
{"id":"19043c89-e8e4-41e5-9a62-c2d63569f4a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827349","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:011c0f4e-6825-4dc3-80c4-bc59a07cf013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5909","original_object":"UniProtKB:Q15391"}
{"id":"df479687-f093-4ebb-87c9-611c80ee357e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229221","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:d8831e6c-d273-47b3-bf40-34b9b9b3d26b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9428","original_object":"UniProtKB:P35968"}
{"id":"d8c8e47b-ea1b-4575-a51f-eb18673a89f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:5aaf3888-e318-4f8d-8d98-990ff9ae7e68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q9H1D0"}
{"id":"95a7290a-79a0-4843-a3da-13389c1ece27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:cb1cb0f6-0246-4925-a1e2-b2e1def3b6b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:P47211"}
{"id":"ad0acb65-aa0e-49b4-8d2c-4e5428fd9c33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16760286","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:579af6f8-1877-4578-b4e1-0c3e6885d9d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5926","original_object":"UniProtKB:P06493"}
{"id":"beb0287f-2eb4-4947-9910-93ab73acaa37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9386","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:53b6f873-aba0-4dd6-95f0-824ea454585e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9386","original_object":"UniProtKB:P08684"}
{"id":"86e4a594-9b37-4e00-8ccd-1e81416ab2a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13905","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:8917714a-09c9-46fe-9e43-8f56cc57a5e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13905","original_object":"UniProtKB:P0DTC2"}
{"id":"b95f48e1-269a-4e0c-bc45-007975457e91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124037381","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:4724bc51-805d-4672-a87d-c28e0d9a5e6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9391","original_object":"UniProtKB:P12931"}
{"id":"19bfa39f-371c-43ce-99e2-b6ab31e046ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2060","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:b572d7c4-2432-44e0-abce-0e3942940f93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2060","original_object":"UniProtKB:P30680"}
{"id":"3a2212a4-c823-47c6-8d96-379a6d189624","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22991950","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:1b05a104-0c60-4abb-8d7c-56967f7c53d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:326","original_object":"UniProtKB:P08482"}
{"id":"5bf34c45-a027-4ec3-a13f-3d1418e5f153","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:a0b0b4ce-02a8-429a-bf69-e349a081715d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P46098"}
{"id":"aec3c45c-523a-4ebf-842f-f9793122b7fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8930","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:587dcff2-30e8-4d04-8c43-93f42ac668e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8930","original_object":"UniProtKB:P08069"}
{"id":"ec61abd6-708b-4939-94b1-1e3a4c61e2c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H4C81M8YYW","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:d8893b3a-230a-4e85-8660-75c6bc444166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6694","original_object":"UniProtKB:O00519"}
{"id":"cbcdff9d-3950-4133-afe3-85d0fe2a4a54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91460","predicate":"biolink:affects","object":"NCBIGene:25400","sources":[{"id":"urn:uuid:d73f637b-0bdc-4d7a-ac01-c25f21877ff7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6002","original_object":"UniProtKB:P11275"}
{"id":"54e47647-339a-45e2-8a63-4b4a8d3f27fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147562879","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:5a85e302-acfb-47b4-9eb0-5a28c74a6e5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13366","original_object":"UniProtKB:Q07817"}
{"id":"a4090c80-f407-47d6-b8a9-a67dae51d9ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643961","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:c9dc37b0-19b3-4286-800a-915a99db8620","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2794","original_object":"UniProtKB:Q8TDD5"}
{"id":"823d0aad-ab82-4719-8b43-7f9eede80bab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11158623","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:eebe2570-f1fd-4614-b73e-c8e587670a55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6226","original_object":"UniProtKB:P31421"}
{"id":"0b9bd961-bdce-456a-b7fd-ba6fcc2db5df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72183475","predicate":"biolink:affects","object":"NCBIGene:811708","sources":[{"id":"urn:uuid:4f1ff64b-ba52-4eaa-a091-8def90047152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9647","original_object":"UniProtKB:Q8ILW6"}
{"id":"5255a222-a7c0-42e3-afd4-d1a255685fa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139412850","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:a6bc8da7-00e7-466e-bfc0-13c2592383a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13208","original_object":"UniProtKB:O60674"}
{"id":"b8f8f7ea-3927-48c9-9f94-12a3a17fefc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33569","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:4a0486f4-54f0-46fb-8778-6708d8796a7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:484","original_object":"UniProtKB:P21728"}
{"id":"14fb7c32-134d-4414-a0fc-41cf1fbc9d0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233644","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:26dee90c-15dd-43dc-8e0e-fbd5081f8cee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2331","original_object":"UniProtKB:O15554"}
{"id":"6a2a57a3-ce58-4107-9bbb-38af6b5e3612","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2008","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:8fdf261f-c15b-425b-9dad-0a54647da236","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2008","original_object":"UniProtKB:P30872"}
{"id":"1e6ef19b-d0e7-4d58-bbee-d656564a1764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16726095","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:3938aaee-6fa0-4566-8aa2-a65f640e9aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6676","original_object":"UniProtKB:Q99720"}
{"id":"197d9b24-67dd-4213-844b-e3b50b61958a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135478809","predicate":"biolink:affects","object":"NCBIGene:7098","sources":[{"id":"urn:uuid:f3a4bc03-ae82-45b3-9520-053e5edc7952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5047","original_object":"UniProtKB:O15455"}
{"id":"064bdea5-8220-45e9-990c-de60dbb5c4e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996540","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:df718b7f-e839-48a4-af3f-6419b5a7097f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10702","original_object":"UniProtKB:P42345"}
{"id":"233bc26d-acb9-4071-94b5-8c0e8b0a7e31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44182294","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:b14b3bb5-0a5d-46fb-91a9-545c21f62093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3121","original_object":"UniProtKB:P37268"}
{"id":"92d8f752-05c1-4cdc-9e3b-47bdd54bb559","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996517","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:ea6f99d6-8960-4365-981c-3f7ddc1e91b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10574","original_object":"UniProtKB:P36888"}
{"id":"13aac7ef-2425-4a8e-aeca-21ba1b17afe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817474","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:9fd21843-07a0-4961-b7c2-8fd908118551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5357","original_object":"UniProtKB:O88626"}
{"id":"077359da-1adf-4b22-b6f8-46b092ca137b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:dd0ac9b3-dbe6-4ec0-838b-9e0973d19ac7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:P04629"}
{"id":"3eb7e76e-92d6-4eff-9876-af2dbce5d2ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:9610dba5-21b8-4b5c-9dfc-eae2d1ab5a1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P34969"}
{"id":"2a34d6a4-abe5-4fa4-ac73-a02270b51b91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16196","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:5b360a00-28ee-40ba-aeff-d3d9b8c7dcbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1054","original_object":"UniProtKB:Q5NUL3"}
{"id":"672058d5-60d9-4af2-a094-59ab759d1de2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2067","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:89b093df-88d3-4b81-81cf-dc28f9160023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2067","original_object":"UniProtKB:P35346"}
{"id":"fa20b53b-31f5-47f2-8774-3fe2ed4135ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:4c3921a2-51d3-4f26-a9e7-dbc7bfa4e702","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:O00329"}
{"id":"9daa7827-8680-43f0-9715-4134daa8c1c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6950","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:96c032b5-de3e-4f79-afbc-3d4bf8f77030","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7241","original_object":"UniProtKB:P18089"}
{"id":"6fd07232-82ed-40ab-a79a-7d161feb527b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2703","sources":[{"id":"urn:uuid:3c4cb372-761b-48b7-a19e-6599255d1624","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P48165"}
{"id":"854ef301-aef6-472e-93ad-e2e68d9b4d9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31448","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:4e96743d-7493-4b3f-a59e-54c6051378dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4167","original_object":"UniProtKB:P42261"}
{"id":"431ae2ad-7476-4d6d-aece-e2156c7845fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63631","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:fcf9896c-f31c-4ab3-8998-f1ed1e26f38c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6849","original_object":"UniProtKB:P00915"}
{"id":"5399b758-29f4-45db-a933-ce8a955aa07a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54758482","predicate":"biolink:affects","object":"NCBIGene:84446","sources":[{"id":"urn:uuid:696c1f1f-4c19-4c9d-8940-370ce7a5ca76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8215","original_object":"UniProtKB:Q8TDC3"}
{"id":"5987e04d-ee0d-4e7a-92c9-d18dd884a9a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:304827","sources":[{"id":"urn:uuid:c9154a7d-c150-4e2c-becb-6ff2e8e4974d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q6UVM4"}
{"id":"d510048d-0fe9-4e0b-becf-aae4f650b7e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:bceb3cc6-57a3-4587-8e8a-440fdc26cdff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:P45984"}
{"id":"f6ecfdf8-693f-4b0a-a4ae-0397bedc8350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10046145","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:6cc1c2ce-3387-4390-a4ef-9ff0217bdd73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5610","original_object":"UniProtKB:P29275"}
{"id":"e2600cc4-ac11-44bc-bf3c-43f4b88610c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11374217","predicate":"biolink:affects","object":"UniProtKB:P0C0L6","sources":[{"id":"urn:uuid:4c59257e-ed68-4a36-bea5-445681b76fd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5813","original_object":"UniProtKB:P0C0L6"}
{"id":"ff328478-f0fd-4163-b5cd-7c94f3f98285","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66899","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:dcaea8ae-2a64-4237-8fe1-841985c77c7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7451","original_object":"UniProtKB:P43088"}
{"id":"b45db57f-018d-456e-ac04-57bedbe2e2f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53262902","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:cc405d8c-3f74-4f34-88da-e632d382538c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4044","original_object":"UniProtKB:P51582"}
{"id":"e2d80ed6-6299-4792-bcb3-1210efeb0f93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:6793","sources":[{"id":"urn:uuid:b0ad3d68-5ce6-480c-b75e-4e47a4ce0445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:O94804"}
{"id":"c5261fb9-df8d-4d84-9eaa-0b5b319b7b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4997","predicate":"biolink:affects","object":"NCBIGene:3568","sources":[{"id":"urn:uuid:b8aadf1f-df26-4767-9351-04bc8d9060dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4997","original_object":"UniProtKB:Q01344"}
{"id":"5b81b738-3b50-49f2-920c-825977abec14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9938402","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:b18afa5c-dd81-4296-b212-99279d052dc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1338","original_object":"UniProtKB:P32245"}
{"id":"f9a7dfc6-d568-432b-85b4-da6269860350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2381","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:58f7d740-9649-4548-bc79-a631d005620b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2381","original_object":"UniProtKB:P35560"}
{"id":"513ad086-5bc7-488e-8379-46a56663cfcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:654","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:901c3dc4-70a1-4e47-b615-91bdc2f5a155","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:654","original_object":"UniProtKB:P46663"}
{"id":"bc0f2781-ce30-47e7-9e3b-fcd37794254d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"UniProtKB:Q9NQU5","sources":[{"id":"urn:uuid:4e82b200-00e1-4247-b222-3e585d0afc79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:Q9NQU5"}
{"id":"9b28ef89-0987-4180-848c-971f9331a7a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64064","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:eaa7e4da-082b-4b63-b783-8adcc6d5c2dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:559","original_object":"UniProtKB:P07550"}
{"id":"03d233bf-e580-407d-9efa-c38e96200fd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10371065","predicate":"biolink:affects","object":"NCBIGene:2280","sources":[{"id":"urn:uuid:c2fe33ad-c8ec-4960-b330-7dacedeeb210","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11480","original_object":"UniProtKB:P62942"}
{"id":"4c1230e6-6925-4a30-8031-a12b175dc7bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51450","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:ae7de3ba-4cd3-4419-9133-122a69b5c82d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3494","original_object":"UniProtKB:P21451"}
{"id":"a0336f67-8d8a-4d31-bf36-501a2d4c3187","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7748","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:3aa6610b-0d01-48db-9b9b-747f9e7546d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7748","original_object":"UniProtKB:P08581"}
{"id":"0f228a70-92bf-4c24-b29a-8d09e5a50ca3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5C1222PBE2","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:3cabc106-47d8-4724-a743-c333a66b6586","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12235","original_object":"UniProtKB:P41180"}
{"id":"91ffd521-f2d3-4771-88db-92e5eb24ea1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138670","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:254cddf2-eff9-4796-bae8-f82de0fb3500","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9839","original_object":"UniProtKB:P53671"}
{"id":"00a943de-9f32-4c8b-ba99-15e962c7895d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11466357","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:c97feb31-65cf-44c6-95f3-20e6c3cb3b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7657","original_object":"UniProtKB:Q12809"}
{"id":"112723b2-d203-4c93-bea5-80ca6cab4d8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603801","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:f36a8417-b175-4faf-90b0-8d1f354ae58d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:153","original_object":"UniProtKB:P28223"}
{"id":"bd7dda71-bd64-48f0-b132-e9d2a1f612bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53233900","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:6ad758ee-f0ee-46e2-bed3-2741bc010587","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6213","original_object":"UniProtKB:Q13255"}
{"id":"463b4280-b2b3-4f6b-9239-f7d6ab405b1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34461","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:a6829f90-4ee3-47d8-862c-dd83402e1f6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4321","original_object":"UniProtKB:P14867"}
{"id":"b1fbaa0d-51d2-4d58-a31a-d2681da649fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5544","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:ca66c537-f345-4e13-9130-d097a8630d28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5544","original_object":"UniProtKB:O35433"}
{"id":"fc1fb056-68de-40b4-9d5b-eccc54700606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5436665","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:bcc1c4af-ce36-43e8-b3b9-998d1c198cfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12911","original_object":"UniProtKB:P36888"}
{"id":"6bcf828e-d3e3-4a8d-b924-672a50519cba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:5637232b-bdbe-48e2-8075-f9adeee5efc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:P07711"}
{"id":"e287e7a7-d070-4e94-97f9-ce80bf85db3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3910","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:958330b2-e5d1-44c1-bc17-7da3b69a8abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3910","original_object":"UniProtKB:P51681"}
{"id":"ecaeccad-2d7e-4573-bdb7-a69e9e5c88f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229902","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:1a53cb99-2c87-4d96-91ba-b36010c6a832","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9280","original_object":"UniProtKB:P25103"}
{"id":"5303447b-2909-4d5c-9273-102efd0b4aae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86703914","predicate":"biolink:affects","object":"NCBIGene:9448","sources":[{"id":"urn:uuid:e3033aad-5e7f-4d7e-b1eb-a2a7310f42ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8134","original_object":"UniProtKB:O95819"}
{"id":"c84d960c-7c82-4e37-90bf-d5e80a1a4a9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91820725","predicate":"biolink:affects","object":"NCBIGene:29028","sources":[{"id":"urn:uuid:fe2a1407-d593-443e-9376-e350d4df86ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8641","original_object":"UniProtKB:Q6PL18"}
{"id":"ff923a0e-2669-4b40-92ac-f5dbc5f7f994","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:e4e3d728-dfa8-444a-adf7-c110601e241a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P32305"}
{"id":"b553ac22-4e52-448c-97ea-67907165e7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90943","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:2325e29b-3a22-4332-aa7d-f2695dd08dbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7719","original_object":"UniProtKB:P00533"}
{"id":"e4635b78-f6ce-43e1-bd27-9fccca434b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42255","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:6cc1b65e-9036-4b7f-8665-d1e33ffc1267","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12461","original_object":"UniProtKB:P59534"}
{"id":"58d79d02-5331-4269-8ff0-0994bcd1e27d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:cf775c1b-0de7-4424-aa58-996a98c3f971","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P29597"}
{"id":"55cc16ac-fd2b-4385-a83b-14d84c82b4c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KZ1O2SH88Z","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:d8f062bd-6f6a-4c1c-9e31-a96b310d6398","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9892","original_object":"UniProtKB:Q6V1X1"}
{"id":"48985724-e796-4246-aac2-dd94b475a0f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118884610","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:18680c1c-3353-4db2-913a-ff9eaea758ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9891","original_object":"UniProtKB:Q9BY41"}
{"id":"ae46158f-a7df-4522-a6a1-acdc9301a4bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:58b8d00c-7fac-4e65-86ee-e825584f0ce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P28223"}
{"id":"32e05317-5a21-47c9-9082-0d83d80fa89f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:637296a5-893d-4f7e-b34a-7285f863466c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P21918"}
{"id":"26e3b433-4e12-488f-9c59-91812c801a37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13316","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:2661cf99-0d2a-4a6a-bac5-d03c7a1c4596","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13316","original_object":"UniProtKB:P48546"}
{"id":"0d15132d-79df-4cb9-86c5-510b0e1d060e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:7ea40635-75cc-42d4-8825-873be60268d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2416","original_object":"UniProtKB:P15387"}
{"id":"9e84d2fe-2080-487e-acda-bfd315a06634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566612","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:42491a7b-32d3-4235-9b7d-6db4e5b5a3b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8172","original_object":"UniProtKB:P43405"}
{"id":"ef9999a7-64e5-4219-a7fc-2c8ba77fb94e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47519","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:67b99b5d-7204-42c0-a640-40695cd768cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2568","original_object":"UniProtKB:P08684"}
{"id":"b045a308-3ad4-4184-a2ce-d73846950868","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:92043599","predicate":"biolink:affects","object":"NCBIGene:2057","sources":[{"id":"urn:uuid:347ecd0a-e9e9-473e-a2a0-34db5083fcac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4921","original_object":"UniProtKB:P19235"}
{"id":"f310f908-f9c5-45ee-b898-cd2afc6fead8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44335556","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:3376fc07-33b5-427f-a7dd-f8eda43d8a23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6257","original_object":"UniProtKB:Q14416"}
{"id":"b3ba9d82-9807-4370-b2cf-ba979df34825","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:fb52f31f-f93c-458d-84b7-185872b56e4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2330","original_object":"UniProtKB:O94759"}
{"id":"5e5269b4-31d3-4efa-bc74-6973b6534364","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"NCBIGene:24473","sources":[{"id":"urn:uuid:e7f98b4b-ec54-4951-9d40-ee4fc3185349","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P19327"}
{"id":"8394742a-c523-4480-84bf-318d036b2510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22314173","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:169801fa-f525-4519-861f-171855209c08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6712","original_object":"UniProtKB:P48449"}
{"id":"21924a61-4695-48db-8385-97c2185ddf18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3467","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:f754bc49-270f-45e9-9bb3-8f75fe23c756","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2427","original_object":"UniProtKB:Q8BLA8"}
{"id":"c6de4019-094d-4a34-9048-71222446af8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:29718","sources":[{"id":"urn:uuid:c0cfaf71-a6c1-4da3-bbfa-6ff86cf3e3ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P49655"}
{"id":"22f467f3-3f40-4367-8290-2658fd235a66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73441910","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:466c39c9-20d7-4da6-87f0-5ba9cdeb7945","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13411","original_object":"UniProtKB:P49768"}
{"id":"88c5cb6b-5a57-43cc-84aa-12c2da647690","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195398","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:3fca4b5f-c228-4b5c-9d9c-c578707fe23c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5145","original_object":"UniProtKB:P45452"}
{"id":"d9620da5-59f3-484f-93a7-8e00a84736cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:800adabd-05e6-4122-b2a7-9470f5b7f495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P78527"}
{"id":"20b06c75-7eaf-467a-a7bd-c5a7a1431615","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136205832","predicate":"biolink:affects","object":"NCBIGene:112399","sources":[{"id":"urn:uuid:ec05401f-ca5b-4c40-b3a1-6d9de3b10b8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8796","original_object":"UniProtKB:Q9H6Z9"}
{"id":"eb091e8a-6e49-4795-a2b7-60001e4d16dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5283035","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:ae703c59-2cb9-4d47-802f-d151599a278d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1877","original_object":"UniProtKB:Q9Z2J6"}
{"id":"ce5b6336-5034-4afc-a1b8-17c8d15a9718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:ed99ae29-3338-4585-bc0b-b8209fbc735a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P30874"}
{"id":"8d934d19-4df9-4bea-8e71-8aac7bc680f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:66769693-c229-4731-afa2-544240b146b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:Q02763"}
{"id":"4a986b3f-5a85-4921-8403-6eeff1c385c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:60ff548c-ef48-4264-92c8-c3ad587c33bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4156","original_object":"UniProtKB:P31644"}
{"id":"56462c84-d19e-4bee-beaa-a82e2c60bf9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28875","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:c44bd537-5d3d-4667-a6d2-f3cf5705cd7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2806","original_object":"UniProtKB:O14842"}
{"id":"927a53f3-530d-43f2-bb7e-3cb9e417619f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92843","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:3dff0a99-a796-4a9f-95c5-e470266a0218","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6015","original_object":"UniProtKB:P00533"}
{"id":"0b1c7874-e264-4444-a188-9db6bef49f62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91433","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:49d493c9-2773-49ab-8965-c145c882542b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9383","original_object":"UniProtKB:P04049"}
{"id":"1d83d656-915a-4441-9040-674e406e8644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449663","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:b90c18a8-316b-4b37-acad-99719db1a38a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1264","original_object":"UniProtKB:Q9QYN8"}
{"id":"e73489f5-7303-4398-b1fe-49c3d06a46e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1820","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:e1ea1bd1-9d8d-4d69-8ad8-9a978784f735","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1820","original_object":"UniProtKB:P49190"}
{"id":"81f11962-dec3-4116-bd29-d87066caa9ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50730","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:2a6c60e8-4a13-4aba-b4d4-af8949675205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3340","original_object":"UniProtKB:Q6NS65"}
{"id":"fee98908-15b7-4c50-963a-eab59bad3b40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947062","predicate":"biolink:affects","object":"NCBIGene:4597","sources":[{"id":"urn:uuid:5291c1d2-413a-4241-8743-9a8ca7ca618a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3205","original_object":"UniProtKB:P53602"}
{"id":"8d218636-24d4-489b-9405-6d974b5fab2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:394ce20a-71ef-4fdd-a622-982f6bf363ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:P46098"}
{"id":"1b18f0e3-19c9-4e4f-9bd7-aa990a25106c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R9X77R42FN","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:fe9b0ae8-2d46-43ec-ab9d-dde439d2d2c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:301","original_object":"UniProtKB:P20309"}
{"id":"73a41ae3-aad6-4f61-9270-b8263853f720","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2000","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:8a739d77-b947-4fc5-bc19-d54e0875914b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2000","original_object":"UniProtKB:Q9NSD7"}
{"id":"58322fde-aedd-4f4a-ba97-eeab8884a32c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136666","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:4a3f1f8a-4f76-439f-a417-4312090d12d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13862","original_object":"UniProtKB:P04798"}
{"id":"c7a138e9-6ebd-4e7b-98c7-65b51f517760","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3DSH8LL4L","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:f436f702-a60a-4d13-b649-51b317c21d11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13397","original_object":"UniProtKB:Q16769"}
{"id":"34083e3e-c533-4447-9c07-f2e77ccde644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111162","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:c5047228-6754-476a-a569-8d44f3f852ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4219","original_object":"UniProtKB:P42262"}
{"id":"8ec80245-5b43-4407-af9c-e0e9637c3986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67469084","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:2cd12d42-3976-48e8-9c47-fcca5107e429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9134","original_object":"UniProtKB:O43353"}
{"id":"b8854caf-3dda-4979-8ef4-8995447d0a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154623230","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:23972e5a-37ca-499e-955d-cdce69f5002f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12421","original_object":"UniProtKB:P30411"}
{"id":"0e6ad1ec-353f-48c0-936a-990c28caa517","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL445816","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:0a63c21b-b817-4b15-8e6d-62b31d9ddd26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2194","original_object":"UniProtKB:P30559"}
{"id":"f7ecc992-536c-48d0-9cfd-a1d428ef1a0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X8EOD1X17Q","predicate":"biolink:affects","object":"NCBIGene:1361","sources":[{"id":"urn:uuid:267097c6-5c2a-44d7-b812-903a7361220f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8675","original_object":"UniProtKB:Q96IY4"}
{"id":"50eaa1a4-1e2d-4353-b352-eb91e09a2e9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:116225","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:864a354f-9a52-434a-bd3b-9498b5bd2128","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4792","original_object":"UniProtKB:P23975"}
{"id":"6372f488-23c1-46b8-80fe-0c8685f7cd2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156311996","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:52982494-82c1-41c6-81d7-4b72365b501c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13294","original_object":"UniProtKB:P21589"}
{"id":"09e8f9f5-2137-4512-abc2-934a63775b27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123790","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:a6c343c2-2f60-4123-ac45-d0f3fe2370d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3445","original_object":"UniProtKB:P04150"}
{"id":"fdf7426b-15b6-4f03-832b-b0a1db0dde83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:aee93db0-ebef-4670-b14a-952dd5b3f673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P41595"}
{"id":"d9fdd528-b203-4ccf-9134-7f597b4c92cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2Z03364G96","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:b6dda7fe-a18e-4b55-b9be-b8d71ad4861e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10056","original_object":"UniProtKB:Q96P20"}
{"id":"0b0e424d-c7ae-4ce0-b547-0bfcfb5b6ee9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803375","predicate":"biolink:affects","object":"NCBIGene:3683","sources":[{"id":"urn:uuid:57028ab7-24fd-45a8-86d8-504fabefab5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9720","original_object":"UniProtKB:P20701"}
{"id":"b45bf8f5-a7fa-4db1-b3fa-439d669bbdce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28241","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:0b3b17b4-aa8a-409c-b7fa-353037c27a01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13147","original_object":"UniProtKB:Q14432"}
{"id":"7ca910b6-2288-47c7-b5f1-4480c8e9c5b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45378170","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:f7920308-e8d2-40fa-969e-8654a5bbc76c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12616","original_object":"UniProtKB:P42345"}
{"id":"36388dc4-d802-44e0-ad09-b827f9c282ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:f57aef6a-50be-4ac6-bdb0-ef45a674f648","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:P35968"}
{"id":"4c866edc-4e0e-4025-bb6d-b6018a537ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1809","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:87e1273a-3e61-4ba8-96db-2a888bfe1fed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1809","original_object":"UniProtKB:P49190"}
{"id":"55f7ee17-41e4-44b7-a8d7-c06bb194233c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611890","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:b9d587eb-0acb-43a8-ad4c-a8397583eb0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9980","original_object":"UniProtKB:Q15858"}
{"id":"3da185fd-2145-4914-89de-fc9b61906440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9N5384XVEM","predicate":"biolink:affects","object":"NCBIGene:215854","sources":[{"id":"urn:uuid:3a6e7aad-6d0c-4852-a79b-55e316e243dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5523","original_object":"UniProtKB:Q5QD14"}
{"id":"42dad363-68e6-4a58-9889-8f7eaf8af7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1584","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:5db6a0cb-bc2d-4586-a43e-fd8cbc76e5ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1584","original_object":"UniProtKB:P70310"}
{"id":"278cf848-bd40-4ae9-9ac1-086ed4588212","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129928","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:678514e9-4691-41a8-9d88-02b7fa8ac417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:246","original_object":"UniProtKB:P97288"}
{"id":"bed1ae15-a119-46f9-a08a-b42a7826e51b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194387","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:f90bb153-2db3-487c-927d-3f4cd05351df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1393","original_object":"UniProtKB:P31421"}
{"id":"8990b4a8-0408-4d43-bbbd-b9bf68c01120","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92537","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:0992a6d1-47c0-42c4-ac55-2cda84176915","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:28","original_object":"UniProtKB:P28335"}
{"id":"a73daf28-37b6-49d1-801f-8fefea71b2f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FUF66UD0KR","predicate":"biolink:affects","object":"NCBIGene:53945","sources":[{"id":"urn:uuid:efca4801-f344-4b2d-9125-b5802c160875","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11183","original_object":"UniProtKB:Q9JHI9"}
{"id":"8263c5ad-e0b2-46ec-9f51-76225a40d728","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0AXW9ALG9W","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:b98a7c3d-1084-4195-b533-2e13f4c462ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8429","original_object":"UniProtKB:P50406"}
{"id":"16d18c14-c6ed-4f9c-8584-1c475c66dbeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FD2SWT2SDI","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:003a3d7f-ad18-4be0-bc34-e1eefc00e2d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6045","original_object":"UniProtKB:P50613"}
{"id":"13a3b698-7d81-4728-b45d-d211a5d80001","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I8C3R768IZ","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:bc0fdc9f-01ec-4b1e-a049-2b49cb32303d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9792","original_object":"UniProtKB:P00519"}
{"id":"68856278-4a0a-4551-9643-df11bea290c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035228","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:5a56c910-44ce-439c-8a12-ebc103b3be4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4324","original_object":"UniProtKB:P56373"}
{"id":"2e32231b-02c1-4237-9e21-476e5e5b5e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9472","predicate":"biolink:affects","object":"NCBIGene:64574","sources":[{"id":"urn:uuid:407e70c1-9592-4380-bc9c-0f067e3850f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9472","original_object":"UniProtKB:Q9JLB5"}
{"id":"e0008f0d-7e73-4449-a791-83fd68d3e506","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:dad57611-d73c-4eb7-b781-b8030847d195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P34969"}
{"id":"61445102-d03d-4de1-b2b8-437da993ae75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94686","predicate":"biolink:affects","object":"NCBIGene:2194","sources":[{"id":"urn:uuid:d93dc3ca-eb5c-497c-bd6c-6596c4964955","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5277","original_object":"UniProtKB:P49327"}
{"id":"2233ca15-edb7-4da6-bef0-1c7d38038749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8NZ41MIK1O","predicate":"biolink:affects","object":"NCBIGene:462","sources":[{"id":"urn:uuid:fb391efa-a5e7-46a8-828a-c04467e7900c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6811","original_object":"UniProtKB:P01008"}
{"id":"47566834-13d3-4072-84fd-51c666bb4054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R9X77R42FN","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:ea02e8e3-5485-41f2-b8c7-23fb80c13407","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:301","original_object":"UniProtKB:P08173"}
{"id":"73e67087-d20b-4a9e-8b8d-02cebec09190","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:94652","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:99ec6853-6734-41cb-9129-9f172678d68b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10337","original_object":"UniProtKB:O95069"}
{"id":"7a39ca42-ddb7-4e5d-bcd2-cb53dde4fc5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2ROQ545LAG","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:e768ea2d-7b31-41b2-a35d-3abe297c67c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11868","original_object":"UniProtKB:P10721"}
{"id":"a5782d9f-7ad6-4845-a15f-e4a954448745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34732","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:74bcb034-10e4-442c-8a1e-46651b1e3990","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2605","original_object":"UniProtKB:O95259"}
{"id":"7ce478c3-00e6-4fa2-b508-8e5843a83d65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:fee92d20-c25b-43f5-8314-80d7dd5a24d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P08253"}
{"id":"7b61dd3a-e0a8-4ed1-a6cb-52e7042f073a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3081308","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:f8439b7b-df79-4413-bed7-3b751cf627d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:657","original_object":"UniProtKB:P30411"}
{"id":"1de8c55e-839f-4ebf-a7a2-b2c905eddca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:7992fb37-939c-4eed-9833-f6e002b0b294","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08172"}
{"id":"8b159fa2-aed3-43ee-98d4-731023d08f68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121445232","predicate":"biolink:affects","object":"NCBIGene:25553","sources":[{"id":"urn:uuid:d82ea190-047d-401c-a31d-d9c4922a4d5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9880","original_object":"UniProtKB:P31652"}
{"id":"8624e78a-c733-44f3-a990-2726489ac048","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679548","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:4212b66f-5d34-4182-8648-c5c1c3e97aec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11941","original_object":"UniProtKB:P00533"}
{"id":"dc73f1c0-c8d7-4b73-9fbd-db3a2f3d7814","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:343450","sources":[{"id":"urn:uuid:2decdf3f-8668-4878-a9fa-a74a9476dcee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:Q6UVM3"}
{"id":"eb538aa0-a90d-4d47-9b67-34a60e1611a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64354","predicate":"biolink:affects","object":"NCBIGene:6559","sources":[{"id":"urn:uuid:c03febe0-2b06-4d5c-b67e-6ffcd5a91709","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4838","original_object":"UniProtKB:P55017"}
{"id":"7038a3b0-9505-472d-bf5d-2662a5fa6579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9953255","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:2dcf1e32-691d-430b-878c-0264b3090bbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:378","original_object":"UniProtKB:P0DMS8"}
{"id":"eb4e609a-354c-4d76-827c-ffcc08392888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MZK2GP0RHK","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:e2248fca-517c-49e3-9e5a-95b39b7921ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8309","original_object":"UniProtKB:P52333"}
{"id":"05f10fb8-35b6-4cb2-8e65-bbba4f572294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280672","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:8202fc9a-544e-4d02-88d7-a6b04c97e150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11881","original_object":"UniProtKB:P23458"}
{"id":"275d3ab1-767c-4d49-9051-d66ede09fa48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131347","predicate":"biolink:affects","object":"NCBIGene:779","sources":[{"id":"urn:uuid:8e132cf1-3c3e-4e2d-bbee-4355fbf81aaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4065","original_object":"UniProtKB:Q13698"}
{"id":"d6c92b00-07cc-4728-b8e2-d1625e395901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KNM216XOUH","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:329ec4d6-0334-430b-a231-23f04ea69539","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7712","original_object":"UniProtKB:P34903"}
{"id":"3003d0a5-d40e-4089-8f65-58dbab102160","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"UniProtKB:Q62413","sources":[{"id":"urn:uuid:b3cdc509-080b-43b6-8b12-faf982dbea6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:Q62413"}
{"id":"34f35b1a-4aa2-457d-956b-d37f8972e5cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123973","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:b1f2ed4f-f21b-4d3b-8429-1bea06205fe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:675","original_object":"UniProtKB:P32299"}
{"id":"00786941-69ed-4186-98b7-645aa50b4704","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2037","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:3be795cd-af7e-42af-a434-e676226992a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2037","original_object":"UniProtKB:P30875"}
{"id":"5bb9d931-2025-410a-9209-02703ba678d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9C8MNF7CA","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:9e1b0a2b-af20-4f9c-bd20-ce90e0b15794","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6700","original_object":"UniProtKB:P03372"}
{"id":"cacefb74-e37b-474f-acc5-565b10815817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3900","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:0f171f35-ac37-4ef6-a2df-c361746ed6be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3900","original_object":"UniProtKB:O60755"}
{"id":"1b93f6fa-b9e3-485d-b124-78be801b73f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993653","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:aa623ddc-3ef5-4dc5-a619-c89fa2feb819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12552","original_object":"UniProtKB:Q8NET8"}
{"id":"f00dd9c7-4612-499f-915d-c3d4152044ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34838","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:8ec3efa6-c1c3-485f-94b4-52a8dabdd196","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6947","original_object":"UniProtKB:P10275"}
{"id":"33697586-1308-4168-b6cf-e1e69199e260","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65346","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:6d925ec3-1aa4-44dc-aa32-47c120d09108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7449","original_object":"UniProtKB:P11229"}
{"id":"9bb1be36-e8a8-4093-928d-44da63d1c671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10427006","predicate":"biolink:affects","object":"NCBIGene:158584","sources":[{"id":"urn:uuid:adab124d-4714-40ae-9dce-4ad91948f86f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5235","original_object":"UniProtKB:Q6GMR7"}
{"id":"c4302367-da7e-492c-8ee7-c2503a61b8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:635","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:1197b926-2039-4b24-a9bb-91e9ab8c69f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:635","original_object":"UniProtKB:P32247"}
{"id":"01548adf-7dc7-4600-b4d7-b058c2be92ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154642303","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:06e55791-2e84-42be-8ed7-15e3120850a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12105","original_object":"UniProtKB:Q02127"}
{"id":"71019afc-c259-4ff2-8e9e-3778b6e12260","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125640","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:db978be8-64ee-40e7-81e1-cf28642ba825","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:372","original_object":"UniProtKB:P29275"}
{"id":"299d8a89-51d5-4192-a488-0a13ae4484b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94506","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:8ca520ab-7b9b-4102-8dfc-c8e27fa81964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5932","original_object":"UniProtKB:O14965"}
{"id":"8ca8c99a-761f-412b-8a62-fa518b75076d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:219564","predicate":"biolink:affects","object":"NCBIGene:9986","sources":[{"id":"urn:uuid:1c88c31d-0fb0-41b0-8f69-de4bf82c3dce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8556","original_object":"UniProtKB:Q9Y256"}
{"id":"b1f68a8d-dcd9-4803-8f05-c02547789e75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:43727c81-b943-417f-8306-0ab6f8323c72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P32305"}
{"id":"941cf58e-db9a-4f26-9437-c5b364160fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2033","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:6b33ec94-6bb9-459e-b31a-94121340323b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2033","original_object":"UniProtKB:P30874"}
{"id":"ab240187-2b77-40e3-b0e1-4b86a32728b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:313639","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:d570af81-758f-4012-9670-830ed41406f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7181","original_object":"UniProtKB:P08482"}
{"id":"89917191-f70a-4949-a7db-3f81f014658a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2273","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:02fd70af-c33a-47aa-9419-5a8c1b34fe35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2273","original_object":"UniProtKB:P41587"}
{"id":"8bbd97af-842d-4532-bd57-d28195ff4801","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122260","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:1b02bec0-8608-4474-9268-0c396397838f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1644","original_object":"UniProtKB:P34975"}
{"id":"8aa14392-36d6-4b1e-bc07-010b20f1b2a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:cf2c22c7-223e-41d8-8d38-4456d273be06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P30680"}
{"id":"02016b96-b18b-49be-863e-25b585f0061c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:821","predicate":"biolink:affects","object":"NCBIGene:12765","sources":[{"id":"urn:uuid:48166b3a-c187-480c-9886-1c3132efa2da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:821","original_object":"UniProtKB:P35343"}
{"id":"1a27fd9f-aaed-4cc1-a65c-0838b0572eb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23657507","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:bf6f1f48-6945-4d75-b9cf-c4e82b09e09a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8146","original_object":"UniProtKB:P42681"}
{"id":"7a371c72-6c8f-4c80-8957-9c361e4ea03e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G8F040299R","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:cba9876b-5c2f-495c-beb5-28a27f8eef93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:974","original_object":"UniProtKB:P30729"}
{"id":"76998be6-f182-4a2f-99ec-00d1da7c76e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030525","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:b68e9342-68ff-4a15-bf4a-1c07218ffa98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10444","original_object":"UniProtKB:P37288"}
{"id":"ee2a82c8-8d11-41e6-8b61-1ec829931d7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:31c2da67-77ce-47d0-af3e-be93e4d4729e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P35346"}
{"id":"df5ae354-2eb2-40aa-87b5-c49411a1b9c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:3770","sources":[{"id":"urn:uuid:ac6365f7-affa-4c57-babc-ca108d4af2fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q9UNX9"}
{"id":"a7af9c57-c43d-47c8-bd97-a4f1a52f9922","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134517711","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:2b2669dd-f08b-4603-b15e-524750f8dc0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13190","original_object":"UniProtKB:Q08881"}
{"id":"e9e6aff2-a5f6-4a48-9719-bd84af5b4989","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FC5AAH89R5","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:8891bf59-3e0d-4c09-947f-a48c7b311748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6920","original_object":"UniProtKB:O43570"}
{"id":"fde7d13d-d4f5-42f1-99fa-09622134bb69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:798343bf-54d0-440f-859e-33985ba51e79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P30936"}
{"id":"3b0db1f2-d380-46c1-a27e-bd5e0ba64499","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9917716","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:66a390c8-79f1-4f0d-a6a4-d013bc16a883","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5754","original_object":"UniProtKB:P25103"}
{"id":"77ccf1ce-2261-48fa-af23-4d6017a0555b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5425833","predicate":"biolink:affects","object":"NCBIGene:13850","sources":[{"id":"urn:uuid:3143956a-4fde-45ed-b9b1-dd6dcb9466ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12354","original_object":"UniProtKB:P34914"}
{"id":"94e78862-3a7a-43c3-804d-17b580368ac0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311382","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:b5a35792-9586-4fb7-94fe-7ff535f4636f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8183","original_object":"UniProtKB:P00533"}
{"id":"765e6aff-a37f-4f77-932d-955463d0dc4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:352d167e-dc71-4065-98ba-500a7f50b52f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:342","original_object":"UniProtKB:P11229"}
{"id":"02e745f2-25b9-4588-9e28-c98d90dda48c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92250","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:ba8df8b3-7a0f-44a9-9a32-e8df41f5af35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:18","original_object":"UniProtKB:P31388"}
{"id":"1261b7b0-ec48-44f3-94c4-96778e110f08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73389638","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:116fb29e-0f29-41d4-a30e-fccde885d512","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9761","original_object":"UniProtKB:P42681"}
{"id":"3caa1440-a9e8-42ce-89c6-850eafda89b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2034","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:ef7344b8-f8a1-4104-a783-585debbfe7b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2034","original_object":"UniProtKB:P35346"}
{"id":"72744ed8-5a08-427b-8ad4-6a6d77c315b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:5ec7409c-4273-4aca-9a8a-4b9eada43f53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08482"}
{"id":"9af22c53-75a1-4a5f-822a-937ca1da2bfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64055","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:8570d334-55d8-45b1-a983-8aca91621967","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:109","original_object":"UniProtKB:P31388"}
{"id":"f5190c88-f405-4e3b-a7eb-2ca5cfa04fbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I18M56OGME","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:f498fdfb-7aa7-4b72-9ca9-7e0a1d3bcaa2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:72","original_object":"UniProtKB:P08908"}
{"id":"c3da7c67-2406-4f9a-ba0c-9f5ec8100845","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91810287","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:3dc6a348-a9fd-484b-8cb4-e0b9d7d3539a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9305","original_object":"UniProtKB:O43614"}
{"id":"f588a19d-0257-44c9-af31-f0cd7249f358","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H4X2M2NN5N","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:3bf6fa86-b8d8-4ced-a6fc-b2817d8656d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9921","original_object":"UniProtKB:P07949"}
{"id":"f89c030e-4253-410c-a80a-4737524ba7b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71655222","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:17183435-7df7-4b85-a92d-02ad15c52cb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6174","original_object":"UniProtKB:Q8TDS5"}
{"id":"e09ae97e-e960-4a99-9a19-8f5b8e20369e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125380","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:6119d35a-556e-4cba-9d24-f9f8966eab96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1413","original_object":"UniProtKB:P31423"}
{"id":"6dbb2c0a-8e70-42bd-ba0b-a12313b7ceec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182364","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:557da7dd-ddd8-43bd-939f-30bdf979245f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8144","original_object":"UniProtKB:P36894"}
{"id":"b25066ee-e5e8-41e0-b1ef-77a9e1c2b8c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:770140J08A","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:9a366173-1c22-4af4-acc4-1c667186badd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11153","original_object":"UniProtKB:P30542"}
{"id":"9ba6bfbf-ca6e-4039-9ee2-1470ce07831b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4545574","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:7c888520-ac3d-4a5b-94ef-ece756ca2228","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1406","original_object":"UniProtKB:Q14833"}
{"id":"cf017591-3495-4f45-b3c0-9ae8fee1d00a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232811","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:bd977681-1aa1-47e9-a211-a7fc93cd2521","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12074","original_object":"UniProtKB:P24941"}
{"id":"2cb3e12e-9c85-456d-9a95-2beb810f4873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76400","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:721497cf-729c-4768-b0ac-43964ff942e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1192","original_object":"UniProtKB:P08913"}
{"id":"dcd89e27-1eea-4cd5-9111-9e42216cf5e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64321","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:12cbe4d1-19d8-492f-a8de-29fce60eeefb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7623","original_object":"UniProtKB:P25103"}
{"id":"2f8263f0-c90c-4d42-82a1-141a2ea390d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S15N98QQ2K","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:0dd8f6db-3fe3-4c18-8a24-0ffd603108d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6280","original_object":"UniProtKB:O75762"}
{"id":"b57d34f7-a6e7-4cba-b5d0-ddd5ab21d2cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:ccae67a1-960b-4292-a892-b2613967fe18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P35348"}
{"id":"5b06f1d1-7a1f-4ba0-ad1b-fa2d6ef8bc0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177416","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:dfad4206-f7ed-4f17-9d61-58c5e8e44fc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10379","original_object":"UniProtKB:P34998"}
{"id":"0c22e515-7165-4c9f-a6f8-016e65424644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142447","predicate":"biolink:affects","object":"NCBIGene:8529","sources":[{"id":"urn:uuid:914ff6f3-8a30-4a01-a2e0-8ee91c24e37c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8851","original_object":"UniProtKB:P78329"}
{"id":"7f6c4b68-8e95-45fe-8dcc-dad4fec8518e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80345","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:2400b34a-38de-44d0-83a3-dd63919cc52a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:860","original_object":"UniProtKB:P30551"}
{"id":"c5b624d9-0a38-435b-9696-d685b3e2a329","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107633","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:719ebefc-9fcd-412d-a600-371154849fdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4323","original_object":"UniProtKB:P46098"}
{"id":"3e27ab26-afa0-4a5f-8b28-13c0479defb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:499361","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:bc0e12e8-ccc4-401f-a03e-42dc68e801bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3490","original_object":"UniProtKB:P25103"}
{"id":"f9a46ae8-b457-44cb-92fd-5b5bcd7cca5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890319","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:578b47e9-ec39-4c07-aa27-e5ba5fa7e503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2659","original_object":"UniProtKB:Q07869"}
{"id":"b72af402-f1b4-4c02-bc3c-6fffcdf02e78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12511","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:569b134d-380d-444b-a0e9-1d41f6fc334e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12511","original_object":"UniProtKB:P24941"}
{"id":"5d3c6f82-8abb-4302-bd04-0e9c3d3bc7ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3PH5M0466G","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:bad6a9ab-dd00-4a8d-8b31-ca02497b3ffe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3668","original_object":"UniProtKB:P33535"}
{"id":"92ee39a7-a9d8-44bd-a1ae-89dd10b07826","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9760","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:69fc0a6e-a744-4d29-9bbb-a7aafddb63bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9760","original_object":"UniProtKB:P47871"}
{"id":"98832b61-5d01-47cc-8c0c-11cde819f8e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92225","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:9d9438c5-ab6c-4fc2-a5ff-ed438ef0f437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5292","original_object":"UniProtKB:P27815"}
{"id":"6b58c73a-28b1-41c1-b104-af3b19e06f18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277836","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:0ce2d2ea-ec9a-4c56-88fc-867dfbee3278","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7770","original_object":"UniProtKB:P49286"}
{"id":"b3e3dea5-f2aa-4da2-8039-ab4a53d5f56c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H2OL3Q4XRD","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:921310f1-c26f-4392-97db-61fd93002439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10460","original_object":"UniProtKB:P08581"}
{"id":"8cb1b3e8-368e-4108-8a7f-aec7296a46ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13818","predicate":"biolink:affects","object":"NCBIGene:51755","sources":[{"id":"urn:uuid:ff42ccef-e5ff-4fa8-ae26-5967c4f57104","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13818","original_object":"UniProtKB:Q9NYV4"}
{"id":"e1fc9be4-1a0f-4f62-a5f6-61fff41dfd38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16618023","predicate":"biolink:affects","object":"NCBIGene:4363","sources":[{"id":"urn:uuid:53ebd417-75a1-4eab-aabc-7b48af66e813","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10372","original_object":"UniProtKB:P33527"}
{"id":"406037e9-2fdf-4896-a152-eab5ca355c94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7458","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:89c664ed-ba12-49f0-825b-a496a59fbe9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1629","original_object":"UniProtKB:P35372"}
{"id":"2ae8bfaa-803b-4941-b40e-e6e12e7d70f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:187817","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:6e9c85ca-10e5-4288-96da-56ca8695d735","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10143","original_object":"UniProtKB:P51449"}
{"id":"b209a144-275e-4746-9d48-c3c6fdaf4be8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422740","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:10bfb78f-cfd4-4d83-afe2-174a56c8f67d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12910","original_object":"UniProtKB:Q96RI1"}
{"id":"cd49f2fb-6d8e-45c9-be0f-b0c23d45baad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:ec9c94c4-ba96-4878-bc53-2061ff20707d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q92736"}
{"id":"f9a6022a-0ac3-491a-b052-028d54346317","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132084","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:664f0f79-6518-43fa-af91-0ee16ce95353","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6043","original_object":"UniProtKB:P11362"}
{"id":"e464a438-a3b6-48e5-bd71-f698a6609cb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:168SF9F04E","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:2497c3db-aa42-44f8-b0e8-39cda2c987b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5617","original_object":"UniProtKB:P29274"}
{"id":"0ae505a4-c627-44a3-8dc4-4da8aa57d152","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75107","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:42031d20-e243-4345-8a8e-0c41968823b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12440","original_object":"UniProtKB:P59534"}
{"id":"704fca13-0d49-4e90-b361-76023d77cef3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10426487","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:083ba857-0042-4915-9b7f-9c11cfeb8dcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:291","original_object":"UniProtKB:P20309"}
{"id":"f216ef65-3bc5-412b-a39a-8c39b34d88aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317992","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:09f7cb23-5f7e-4a72-8b1a-7f46be787a4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3248","original_object":"UniProtKB:P34969"}
{"id":"958e3dca-19a0-4328-9898-d39d3819e06d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232499","predicate":"biolink:affects","object":"NCBIGene:9097","sources":[{"id":"urn:uuid:04ead01b-852d-4669-8d89-41e40d896db5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8880","original_object":"UniProtKB:P54578"}
{"id":"0ddad37e-16cd-428d-93b8-e1c9f1193cb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:93a7ef07-c955-40dc-a7e3-1371def10a7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P28221"}
{"id":"3edaa2dd-d941-4858-9fda-28346bdfa1ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57336812","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:42183387-7de5-4529-a020-30645ff25971","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9387","original_object":"UniProtKB:P52333"}
{"id":"158a46c3-2d4d-452a-ad04-3778e026005e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233359","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:8e024f4b-d230-48b1-af41-6b19b9ef2f1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11782","original_object":"UniProtKB:P50750"}
{"id":"37200f44-43dc-435c-b19b-290f743c93b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46195","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:c40d1788-ad0e-41b7-b256-a0f271fa0982","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5239","original_object":"UniProtKB:P35354"}
{"id":"da8fb7b6-a903-4ed9-bb46-fd949fb92e65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46836953","predicate":"biolink:affects","object":"NCBIGene:3248","sources":[{"id":"urn:uuid:c3b975df-64d0-4d1d-a4e1-ef5bc48078d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8745","original_object":"UniProtKB:P15428"}
{"id":"c26b6f63-5e53-4160-984c-de56f7e62fe3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156768862","predicate":"biolink:affects","object":"NCBIGene:1075","sources":[{"id":"urn:uuid:a8662557-50dd-48ad-a03b-86266eda80f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13959","original_object":"UniProtKB:P53634"}
{"id":"7db974a7-603a-421f-b345-f223973bb11b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13714","predicate":"biolink:affects","object":"NCBIGene:7099","sources":[{"id":"urn:uuid:74ed4748-bb77-4fd7-9937-98c6108504da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13714","original_object":"UniProtKB:O00206"}
{"id":"383cc781-7356-456f-97fa-db8656bf6fe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:1992b3d9-d690-447f-96d3-7270ffa1d52a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:P80192"}
{"id":"67b88d46-149a-46f5-bf9b-014973091013","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3901842","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:0c2e001e-96b4-42c8-9252-799d54adcdf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5833","original_object":"UniProtKB:P21462"}
{"id":"dc5a73be-ada2-410d-bfd8-288ce420db29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:4638","sources":[{"id":"urn:uuid:ba2d311d-58e6-4c02-b536-221ffa92a199","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:Q15746"}
{"id":"873193f5-b501-49a7-9c6b-5f20e1f36c9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229886","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:20f15951-830a-4f52-9b7d-0870ad8f93ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6558","original_object":"UniProtKB:O76074"}
{"id":"e3d94f35-0b94-4b8c-b7c5-bb45d630db15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9811445","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:6f62a839-93be-4f63-bda9-e7fab0dff2be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2321","original_object":"UniProtKB:P70605"}
{"id":"4377e0ce-e03c-44f3-bd58-6d3bcde5a49b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124112161","predicate":"biolink:affects","object":"NCBIGene:8876","sources":[{"id":"urn:uuid:10a39c28-4b77-42cd-8a31-6ba18b0f9293","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11718","original_object":"UniProtKB:O95497"}
{"id":"ee90b37a-d721-4696-bb6c-59cbf7f3f20b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125380","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:4bbf76c7-2d43-4431-a420-9b9cf19829cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1413","original_object":"UniProtKB:P70579"}
{"id":"3f38f35f-9530-4500-9054-6cf5e1b53c87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2261HH611H","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:35dbfcde-9b34-4734-81f8-5998543be4fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9907","original_object":"UniProtKB:P42338"}
{"id":"d2207463-4353-4423-beb7-6eea9ff80d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10281725","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:4ad47f20-4e14-4070-a878-03df6edd48da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:666","original_object":"UniProtKB:P46663"}
{"id":"2f261b06-c6af-4c8d-ae7e-e670a87fa7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44423","predicate":"biolink:affects","object":"NCBIGene:6241","sources":[{"id":"urn:uuid:cfbc369e-588a-4dec-a04f-36d5863f30a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6822","original_object":"UniProtKB:P31350"}
{"id":"eac5f57e-708c-488d-9a0c-9405fbbc7ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9938990","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:3f55f81d-0162-4640-be6a-e03d4af6706d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2133","original_object":"UniProtKB:P29371"}
{"id":"688ace99-0f50-494d-a132-019b88c1d11d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4869149","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:c666349e-c8b0-4cbe-877e-efc8c0eda245","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11690","original_object":"UniProtKB:P25440"}
{"id":"644de798-064a-4eb3-b539-c18b0450deef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3103","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:5288b1ad-cc8c-4caa-b970-2a2f1770b797","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2366","original_object":"UniProtKB:P23416"}
{"id":"35425db5-e68a-49a8-b7e7-bb061e8f15c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24750192","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:988406fd-9125-4309-b8aa-0f2e7d798b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7777","original_object":"UniProtKB:P48039"}
{"id":"c96b9a3e-ad66-486b-82d9-74a01627b4a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6931","predicate":"biolink:affects","object":"NCBIGene:25570","sources":[{"id":"urn:uuid:7a46486c-24ec-4f0c-97e3-06e7479f74e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3342","original_object":"UniProtKB:Q01717"}
{"id":"316931eb-335b-4289-af77-536cfa6a3634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:1cd3f276-895f-4a59-afee-e0472d2332a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2645","original_object":"UniProtKB:P19793"}
{"id":"24669156-7b91-489e-a8f6-f032001d852b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11624321","predicate":"biolink:affects","object":"NCBIGene:24451","sources":[{"id":"urn:uuid:e0dcae2d-8e8b-489d-9366-d2c67533d8b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8873","original_object":"UniProtKB:P06762"}
{"id":"dc84d8aa-e6ba-452d-bc8c-656819edde62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494257","predicate":"biolink:affects","object":"NCBIGene:11091","sources":[{"id":"urn:uuid:14ea3f7c-3421-4a88-b4cd-c73a996a6f74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13061","original_object":"UniProtKB:P61964"}
{"id":"fcfdb2db-585a-4e25-8406-1e0839f45f46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131490","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:4e3d07c5-0604-4afe-8e54-be79235a7cf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8018","original_object":"UniProtKB:P06493"}
{"id":"f7a41594-cac3-447a-9e2b-8a21fa6cc3b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188637","predicate":"biolink:affects","object":"NCBIGene:1071","sources":[{"id":"urn:uuid:cbdfc9ff-6040-442b-8d5d-cb60bfcdeaa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8401","original_object":"UniProtKB:P11597"}
{"id":"0cb88993-acbc-4113-be5b-ee1d6a28f716","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J5PMS063XX","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:009eb5ef-0540-406c-8431-453ded2a18d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6429","original_object":"UniProtKB:P41594"}
{"id":"c30ee35e-9767-41d9-ad0e-1afddf35ee92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437864","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:8844ddac-417e-4c8c-80db-accca6d9a289","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2103","original_object":"UniProtKB:P29371"}
{"id":"3fd30cce-9196-4bb5-af45-bddef85373b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4638","predicate":"biolink:affects","object":"NCBIGene:259295","sources":[{"id":"urn:uuid:4e416123-a656-4c6a-97ac-7588c3d22990","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7163","original_object":"UniProtKB:P59543"}
{"id":"1c2bc626-666c-433e-9692-2fea103836bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4284721","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:de298129-f6f7-438a-96e3-6a85b98b4faf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:248","original_object":"UniProtKB:P97288"}
{"id":"940aae25-7b1e-4a7c-a654-8f1d969a639f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:5649e67a-695f-4c35-aa96-fa795ee60e63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P28566"}
{"id":"e1e6c580-70e3-45b5-847c-414da7039edd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:530596af-10f3-4d01-bde4-ce0056e39dd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:P36888"}
{"id":"b8ebcec4-94dc-4a94-84c1-94f877f19da2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2548547","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:5944b125-d185-4116-a3ab-524b8f5fad0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8766","original_object":"UniProtKB:Q6DWJ6"}
{"id":"e251c713-888a-4970-a511-31921fba48ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:aaf0d128-e2ea-4267-b648-074ab0e435e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P07550"}
{"id":"e22ff704-0390-432f-b3cb-8605b5135095","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900913","predicate":"biolink:affects","object":"NCBIGene:8576","sources":[{"id":"urn:uuid:3ec7091e-7af9-435f-a2a1-48f374ec5d26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11895","original_object":"UniProtKB:O75716"}
{"id":"7f99b892-8882-45ad-8648-ee60ac7f6c3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53238781","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:9cbdb6aa-a947-4c77-b655-ddfe16d69092","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5789","original_object":"UniProtKB:Q8TDS4"}
{"id":"87933a7d-a2e1-417a-bf51-21bd154fff80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BRJ718SA03","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:d198d286-6ced-44e8-a308-73f97f41f77e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9003","original_object":"UniProtKB:P41145"}
{"id":"ca28739a-3174-451f-827a-accbdf577c17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996536","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:37272f44-66a0-43dc-b20e-b2b6bf4965b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10649","original_object":"UniProtKB:P42345"}
{"id":"11f2c2b0-9419-42a6-805e-9f101f69c2a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:94168F9W1D","predicate":"biolink:affects","object":"NCBIGene:21338","sources":[{"id":"urn:uuid:f7e87506-38c6-470d-9906-3abc2e7f31e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2089","original_object":"UniProtKB:P47937"}
{"id":"6932589f-4067-468c-8cb3-55dea0c3e47a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:262AL91J0Y","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:fd753a8a-06bc-40ae-b6fd-c8830a050df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:674","original_object":"UniProtKB:P30411"}
{"id":"7fd07e35-d364-45f8-b746-db591d242372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:486830","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:0a2f3392-952d-4125-8ef2-99799cd0615a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:768","original_object":"UniProtKB:P51681"}
{"id":"4c1d662f-2fc4-4c0e-b9b5-3304819161fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67209274","predicate":"biolink:affects","object":"NCBIGene:292794","sources":[{"id":"urn:uuid:971845ff-2a06-471f-b802-20c3c986ea9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6488","original_object":"UniProtKB:Q76EI6"}
{"id":"6464a385-b595-4b80-b0f3-2e5f96bc2661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FF33NL9U5G","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:e5c43408-751b-4c7b-9978-7b5d5ee77ff3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9060","original_object":"UniProtKB:Q92847"}
{"id":"c1bbe247-d932-4592-9705-3157a6550404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TE20GB753F","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:9263714d-2e14-471d-8422-5473468eb7d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9930","original_object":"UniProtKB:P10721"}
{"id":"406c4864-e938-431c-bd86-7c7ca8678f9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27965","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:f1215c66-cfb4-4035-a5d4-b947c28310c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8981","original_object":"UniProtKB:P25021"}
{"id":"5de64299-a4e0-4b5b-8d88-5a0a84ec1774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122530045","predicate":"biolink:affects","object":"NCBIGene:305795","sources":[{"id":"urn:uuid:5ad83f21-9dcd-4b48-a790-ef102447f868","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11816","original_object":"UniProtKB:Q5XI64"}
{"id":"6347bad3-be4d-4cad-a1c2-b0ab5d454f32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5899","predicate":"biolink:affects","object":"NCBIGene:65096","sources":[{"id":"urn:uuid:a4a6148c-b9ec-4396-bd62-c56c7f344029","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5899","original_object":"UniProtKB:O88917"}
{"id":"b8ab5a61-0a9f-426a-94e1-fa2037cf60ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:78585f61-9bf1-460f-a7d9-a27587d971cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:O08858"}
{"id":"fc62c09a-8bc7-4f6f-af4d-23df7ebbfaae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321935","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:1c6b3b50-b54f-4070-888d-d5bc1b821dca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4074","original_object":"UniProtKB:P46098"}
{"id":"d0e35fbd-b1c1-4b1b-9590-eea9deab7acf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94302","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:5b3285b8-23b5-4cc8-9311-3396617fcffe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8011","original_object":"UniProtKB:P42336"}
{"id":"862d216a-1c3d-49b6-ba31-5d828a0cd351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y6BX7BL23K","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:3bf48ddd-bd65-4086-9212-cf4355c4fd55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9767","original_object":"UniProtKB:P11362"}
{"id":"994d03f9-ab1f-421a-9042-8c4c6a5f25d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64028","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:fe0ec8b1-2117-451a-8419-99959c5ec43f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4834","original_object":"UniProtKB:Q05940"}
{"id":"98e82f06-2a87-4c45-9ac3-cc54e10152e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2383","predicate":"biolink:affects","object":"NCBIGene:29713","sources":[{"id":"urn:uuid:976ff808-0ec4-4bad-a33c-23b617e4e824","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2383","original_object":"UniProtKB:P48548"}
{"id":"027eb595-aaa7-4f23-bfbb-faeab62549ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73386890","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:831e6002-04e7-4af0-b423-cdf95edc5fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12706","original_object":"UniProtKB:P45983"}
{"id":"aed0ef3c-56bc-4f1f-aa55-e8b1d77f5d4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134405105","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:556ba88b-1671-4bbb-9773-bda48bd98ca0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12621","original_object":"UniProtKB:O60674"}
{"id":"76ae4f51-2a71-4c60-8fd6-c171e7b31788","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88249","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:6eb93969-f100-4c76-9e80-86cb4f328485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7935","original_object":"UniProtKB:Q02750"}
{"id":"06d7040c-c4b8-4a1e-90d4-40ba0a6056a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53868701","predicate":"biolink:affects","object":"NCBIGene:55170","sources":[{"id":"urn:uuid:c031b7e5-0cb2-4c7c-aae0-5b14ccdf80ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9529","original_object":"UniProtKB:Q96LA8"}
{"id":"a4ae9bec-dc34-41f3-84c1-ee1202964680","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:922","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:7eab6cec-1bda-4e77-884b-9e717aaeed34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:922","original_object":"UniProtKB:Q13324"}
{"id":"1f2ab348-8a58-456d-8df9-6f76d4ceacad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145365","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:7379a11a-1073-494a-9438-77e71be96f80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7882","original_object":"UniProtKB:P09619"}
{"id":"e5552351-b43f-47c1-b2b0-991ecf86339d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DWQ8UHZ38S","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:c0d3b3c0-ae8a-4dab-9406-ca58040d27d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1724","original_object":"UniProtKB:P47900"}
{"id":"66617c14-1570-40d8-8a79-a2e9f90fa633","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18346","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:12556f54-7a4f-4e13-83f7-c6146dd50277","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6412","original_object":"UniProtKB:P59534"}
{"id":"f4103888-f879-4d45-b970-8a0f979de042","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:921","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:35fe3157-ab57-45d2-97a6-a27b3a11bce3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:921","original_object":"UniProtKB:P47866"}
{"id":"ff8470a2-887f-4bfd-b67a-0111b8659850","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4ADT8JXB9S","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:1c3fda0a-8f4c-4b35-a999-4bbcbf551825","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8948","original_object":"UniProtKB:P25024"}
{"id":"7d23f313-ba73-4247-99fd-acec0238a715","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6095","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:2e483c7c-ba7b-490f-b5c6-ecacb6dfa11c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6095","original_object":"UniProtKB:P47211"}
{"id":"75378252-1b9a-4299-a0cb-1ca65cbdbf7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:91d3910c-927b-467d-aebf-72c18492f449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q9UKV0"}
{"id":"111897fb-5be6-4d43-8410-f7e2d4fdda6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190735","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:29fac60d-ef27-4268-896a-c52d81cea15c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1064","original_object":"UniProtKB:Q9Z0U4"}
{"id":"e1662b87-7940-49cd-9a16-1141adad4372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5575","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:9189ed21-d766-4e7d-8a31-b8b903d84932","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5575","original_object":"UniProtKB:Q03431"}
{"id":"300de367-731b-47f1-88e6-612af5d8c351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32223","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:ed0cef7a-1db8-4d47-be17-362759fbac8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9711","original_object":"UniProtKB:P03372"}
{"id":"d93afa32-4e2c-4cf8-869a-1a52dd7e77bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K08BK043YS","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:c23adb13-114a-4435-b56a-9e5887c9c6c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5752","original_object":"UniProtKB:P25103"}
{"id":"275a0f5e-16a9-4ec3-938f-ed05c8e44faf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73297","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:6e658a59-4302-43b5-b6a6-edbd5b2ed7a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:943","original_object":"UniProtKB:P48050"}
{"id":"9773a705-e73a-4602-9292-c8c6cb7eebcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817490","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:f3546f2b-a2ef-430c-8ce7-5eae84a22277","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6168","original_object":"UniProtKB:P30550"}
{"id":"a85585d4-2f7a-4346-b79d-8c21946a26f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:6c20a77e-649e-4069-82ca-f4c5fb6bcb3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P14416"}
{"id":"929d828f-af71-4682-9598-07ea883da36e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180876","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:18d59fea-4598-425b-9b94-7ca519250ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:208","original_object":"UniProtKB:P14842"}
{"id":"ea194b7a-5760-4606-bfd6-4aceaf4e209f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85161","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:e85c3f46-a759-45d2-9dce-72c97063b98d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7486","original_object":"UniProtKB:P46098"}
{"id":"4f708d34-2e62-4183-831e-db3c1728b232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76K17ZG4ZN","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:0800cfec-9e67-4c95-b1aa-05246bc9cbdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:767","original_object":"UniProtKB:P32246"}
{"id":"129f8eb3-50da-4244-9b5a-b0afa73a768b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:c95bc908-0608-453f-991c-efd1ee598ceb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P00533"}
{"id":"bf7d13d3-7a4f-4058-b88b-502196c2e3b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947034","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:f0dc3180-dde7-42bd-81f9-be0abef27275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2996","original_object":"UniProtKB:P51639"}
{"id":"bbedd38f-fbb2-41f6-9aae-6ed323092c4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17379334","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:9737d981-9f94-48d6-86f8-98f47c7b3d0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9748","original_object":"UniProtKB:P33535"}
{"id":"4f78e412-89ee-4985-a084-98e6a2ba4b7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:bd6c487a-cbb9-45b8-89ba-30538a5b434d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q9Y5S1"}
{"id":"59052396-e0bd-431d-8c30-6ccaafbd0a71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:2112b945-d4b8-473e-a0e0-c0f40ec187a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08485"}
{"id":"12ecebf6-328a-49ce-b64b-17a3b07e3f68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71487030","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:18782f56-c406-4872-a93b-472170f26f93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13783","original_object":"UniProtKB:Q99500"}
{"id":"ed0f39af-8230-49ff-a4cd-fb9674ea8a9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129027150","predicate":"biolink:affects","object":"NCBIGene:54583","sources":[{"id":"urn:uuid:1c613180-909c-4650-966e-08e2990d6ea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12785","original_object":"UniProtKB:Q9GZT9"}
{"id":"261c68ba-82fc-4870-a631-f79486c0f7c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38545","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:706dd9b3-fa5c-4f36-a2c7-c9560688a0e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2954","original_object":"UniProtKB:P04035"}
{"id":"7c3599b1-14dc-46c6-9690-be246aadf923","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1044","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:0ea0ca64-98b9-45ed-92bb-758dfb3003bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1044","original_object":"UniProtKB:P25089"}
{"id":"a0728038-7e63-4475-befb-e3e3acb06b6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15646","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:abf5d04e-f4be-4f66-9826-f21ba2c55f10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3399","original_object":"UniProtKB:Q15722"}
{"id":"7dd1153f-1691-4904-bba0-d96dbb68de15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1126","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:c15e5c4a-b222-4bfb-948b-3aebd2eabac6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1126","original_object":"UniProtKB:P43219"}
{"id":"eee88ff6-4bd2-4caf-96ed-2097c3b86ccf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229233","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:600dfcb7-2c80-4bce-ab72-2533e383da55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9559","original_object":"UniProtKB:P23458"}
{"id":"1826540b-fff6-456f-9d35-a177a5b1b36c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:abed6991-9709-4dc1-bf00-42bbb740fedc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P30542"}
{"id":"4bb2a7a1-1c04-4c3e-9afe-4a1ab972db0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8502","predicate":"biolink:affects","object":"NCBIGene:7173","sources":[{"id":"urn:uuid:12c53c5a-578c-41bc-ac09-5c9f17a51a1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6650","original_object":"UniProtKB:P07202"}
{"id":"99481bd6-3279-407c-8895-12820d184a04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92845","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:2809e533-9271-4649-b4a9-7d81ffb52f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2429","original_object":"UniProtKB:Q8BLA8"}
{"id":"23f4d2a6-7335-4707-97b3-87178e37bb9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4Z63YK6E0E","predicate":"biolink:affects","object":"NCBIGene:952","sources":[{"id":"urn:uuid:39f14f46-892f-4a47-8e7a-7cc13b8baaf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7395","original_object":"UniProtKB:P28907"}
{"id":"fcee6ec6-cf88-4417-8021-5f26fb3bfeec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0ZZF1V8G63","predicate":"biolink:affects","object":"NCBIGene:4846","sources":[{"id":"urn:uuid:2911e751-19c4-4be3-ae15-46ffe37d6671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9849","original_object":"UniProtKB:P29474"}
{"id":"04b33006-9bb4-4389-96c5-2761e5ea1420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6102","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:679a4143-ae54-4272-bfb7-c690d9ecc8f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:650","original_object":"UniProtKB:Q61125"}
{"id":"6fd5c450-1b8e-4b7d-bf2e-b48cb6ca2dee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X46FC5N190","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:ab5a84eb-27b0-40bd-b523-002568ecbfa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4209","original_object":"UniProtKB:P42262"}
{"id":"ccf85bf4-9772-4303-9f5c-fda3b0dbab30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:66QR34C83N","predicate":"biolink:affects","object":"NCBIGene:10855","sources":[{"id":"urn:uuid:4fa46a9a-6fab-41a8-8c8b-bdb7b4c1ce36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9870","original_object":"UniProtKB:Q9Y251"}
{"id":"dd8ef06f-e5e2-47ea-9c53-283f14c2436a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4315","predicate":"biolink:affects","object":"NCBIGene:777","sources":[{"id":"urn:uuid:106c5d3c-3267-4330-992c-b4e79c728a9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4315","original_object":"UniProtKB:Q15878"}
{"id":"b6d9c65c-23bb-4316-9c95-a3db854a07d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10127","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:ff1c8576-df77-4d5e-ad7d-9feac6095cfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7047","original_object":"UniProtKB:P43166"}
{"id":"6234a7fc-041d-4889-901b-04fa1b084cbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17276","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:d143e35d-dd8d-4d19-8b66-8a76387b58a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4285","original_object":"UniProtKB:Q9NYV8"}
{"id":"d28fc8cf-36d7-4a5b-b094-9cfee48ed733","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67983123","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:9d152246-3955-4abc-960d-aee7cc2f7b0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9379","original_object":"UniProtKB:Q8NEB9"}
{"id":"360787bf-c81b-4b61-9461-cd68dcd4452c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:88SI3G560K","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:d46afb88-6bc5-4e1e-9969-f2685d32ff57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1978","original_object":"UniProtKB:P21731"}
{"id":"eefaa4b4-e49e-42d3-9459-8fc17a93e873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1329","predicate":"biolink:affects","object":"NCBIGene:17199","sources":[{"id":"urn:uuid:ec6dd2c4-aa04-40c1-9001-7d0d0196237b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1329","original_object":"UniProtKB:Q01727"}
{"id":"1a509b66-f2f7-47a9-ade3-5de814317dc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10475079","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:1e586f50-fbe0-41be-970d-5022ea41d4f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3061","original_object":"UniProtKB:Q02769"}
{"id":"f308fe63-af2d-44cb-98cb-8dde3ffb564c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8921","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:76e62463-b343-4b8e-a7c3-52aa03092c2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8921","original_object":"UniProtKB:P41597"}
{"id":"51f759eb-5295-4db2-ab97-77592c60c831","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2834W8D6GK","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:7ab3e5d7-27f7-4512-884b-34ccc79e3a69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9963","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"44dc8b25-3152-4254-b490-e9f736b5aae1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:f48dbea0-50f3-42ff-b533-3cbd9473b248","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:P05129"}
{"id":"672dde37-1cf2-4fd2-aa24-2023afab5c90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9811445","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:760f567e-1b0f-46d2-b57a-248fdbeff04c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2321","original_object":"UniProtKB:Q9H2S1"}
{"id":"789d0d89-0587-4b6e-a6c1-aab838640ba1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2024","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:6fb86ec5-9e19-453e-a89c-be3b1680cb2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2024","original_object":"UniProtKB:P30874"}
{"id":"dd6675dd-4b37-4e8e-8984-c5002d5ae0a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3728","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:ea393dad-5ea8-4f28-8105-6316180769bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3728","original_object":"UniProtKB:Q9P296"}
{"id":"ed48993c-acf8-4b75-99cb-afc2435d72a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1272","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:df5ca5f0-79bb-4f3e-9154-b5013ef4577e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1272","original_object":"UniProtKB:P41597"}
{"id":"8802286f-4ebf-4333-a878-b50be804931e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:20f8d3d2-4cfb-4199-81a8-09c9f4d4806d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q15413"}
{"id":"32d1142d-9d21-4eb6-ba5c-3efc78a24596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L1V1K2M4V","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:26010011-28a1-4ab8-abfb-cc6be8df0b5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4461","original_object":"UniProtKB:O43613"}
{"id":"f7460120-6aec-4b3e-beb6-97279fd56fab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9860294","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:7c7a1040-f675-4bdb-93c4-9787be62538b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5613","original_object":"UniProtKB:P29274"}
{"id":"1232b618-87fc-46a0-a303-bf327e08198d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64019","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:36b5547d-2579-48a9-bf8e-abdcbbb0de52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7246","original_object":"UniProtKB:P08588"}
{"id":"04c67822-02b1-4079-a8b5-98de63119f08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:6928f2d7-969c-44a4-9c56-1af8ee1fd68a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P18825"}
{"id":"98e347ac-3b49-4a00-b496-67a8218bf3c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10567","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:5147b113-8c87-4fc4-9c53-40910305dde6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10567","original_object":"UniProtKB:Q96LB1"}
{"id":"79ae2be1-ea37-403e-b894-d7d0d19785da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6498","predicate":"biolink:affects","object":"NCBIGene:14294","sources":[{"id":"urn:uuid:25d3f08e-cbdc-441b-9fa1-09643147f96e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1034","original_object":"UniProtKB:O08790"}
{"id":"6f50a28e-baef-43c3-ab63-88139fc6f8fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24890862","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:4a3b664b-d73a-4342-9a6c-192356f16010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7755","original_object":"UniProtKB:Q99705"}
{"id":"2cb3c86f-3495-4329-a99d-44de0c99a290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23652660","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:a4d51af9-61aa-4fa5-a501-7e191bb01050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9357","original_object":"UniProtKB:O14920"}
{"id":"14976ac4-12c9-41b6-b7dd-59be21f66d4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R4HH3BUP3T","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:95168ea5-0bec-403c-bf53-11b6c763dadc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4274","original_object":"UniProtKB:P39086"}
{"id":"f59cf6bf-93f5-40d2-a100-3d4876bdfc18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B1X701S0MV","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:d5561d3f-5b9a-4f66-ab0a-bc5ee20cbfe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1595","original_object":"UniProtKB:P49019"}
{"id":"1764d5af-bfb4-46fc-bb98-24c91d000909","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:766","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:c0094f0e-48e1-4287-a967-690423f285e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:766","original_object":"UniProtKB:P32246"}
{"id":"59167883-a86d-450b-b112-8b8b90a594d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6147","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:45121861-72d7-4fee-bf38-1b06774cb893","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:622","original_object":"UniProtKB:P24053"}
{"id":"a004e998-c780-475f-93ab-6dd27c0b5c03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63949","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:8d038ee0-5a27-490e-a520-9f93d7307a40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2825","original_object":"UniProtKB:Q92731"}
{"id":"08b6c2aa-39f2-4404-9936-5b2674921606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8459","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:49d693fe-b5aa-40db-a4ff-eae1b186120d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7281","original_object":"UniProtKB:P35462"}
{"id":"27bc19d7-3260-455c-8677-7cad9ce95b5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DRU6NG543J","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:feabec1c-d693-4455-a17e-acae5135f171","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7837","original_object":"UniProtKB:P07947"}
{"id":"59ba9081-9ddd-4c2a-919d-76a220d1d7af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53325875","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:935ab2d9-62c6-4e6b-ad2c-96be357c25b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4122","original_object":"UniProtKB:Q99572"}
{"id":"2cce7f50-ffc7-4c67-b073-24e1a91dd3bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6137","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:cb6a9aeb-40fb-471e-8c0a-66cc057bfb2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6137","original_object":"UniProtKB:O43603"}
{"id":"b7fd638a-f2bc-43ee-b6ad-c0a69af0506a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10082","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:9d2e619e-b607-4019-aeb0-cfe56dd7d309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:517","original_object":"UniProtKB:P18089"}
{"id":"bb629a5b-a76f-4489-806b-0a192c2cf656","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90942","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:4297f725-2353-424a-982f-952c545ed9e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8450","original_object":"UniProtKB:P28074"}
{"id":"795dd5c5-3a52-43e5-965c-f2c40263aefe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:309edbe3-d9cd-4f76-9e73-c54f21bb584a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P08913"}
{"id":"9f8ab0bc-6254-4b5f-8884-16b59eceb5b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WFG29AB872","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:4c71e488-1627-479c-9cf2-a5c791ab2f80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9928","original_object":"UniProtKB:P42338"}
{"id":"c9966df5-75ed-4415-8c7e-8d1880b2e132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1545","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:b2a79bc2-9e5f-46c5-a630-79443c6d4ffa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1545","original_object":"UniProtKB:P49146"}
{"id":"821c0669-4fc6-4c11-a5e3-fd33af656ade","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140936","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:9a53db9e-548d-4c58-a82c-5ee68d68e9bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:221","original_object":"UniProtKB:P41595"}
{"id":"5a24e610-4caa-4809-9710-20ad7e951b69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1512","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:d2c474ea-7c89-42de-8a44-8748e08197ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1512","original_object":"UniProtKB:P21555"}
{"id":"9f4fcdfa-5ae6-43cc-a848-ed284dd963e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4470","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:35821d1b-8856-4eb7-9490-af918cf35a21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6953","original_object":"UniProtKB:Q99720"}
{"id":"b4aa8dad-fad4-4818-95ac-ce34276fdae2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92070","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:f43adb06-0b57-4b9b-9a16-e4da200f3304","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:94","original_object":"UniProtKB:P61169"}
{"id":"66fc0847-acd2-4961-8f84-a8983eb183e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81724","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:83c986a6-a794-4891-baff-f21bc0c251dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10307","original_object":"UniProtKB:P78348"}
{"id":"d66142c3-d017-4dfd-8adb-5131c073cc6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13499360","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:8dcca987-a268-4609-967e-18c556888c3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1249","original_object":"UniProtKB:Q9Y5N1"}
{"id":"ae217a6d-e0a0-4bd2-bd03-f0bf7841d43d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17053","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:118284b5-f338-4f66-b3ec-38e7fa7a95c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3309","original_object":"UniProtKB:Q14957"}
{"id":"f16570c8-7d9a-49c7-b116-2469070d7d5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49867142","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:2c51dfbd-8278-40ad-84c7-554fa8bf8b60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6201","original_object":"UniProtKB:P51582"}
{"id":"1a06c0e0-44f3-42e9-914d-c6fa4eb180ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9398","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:46b79708-da26-4782-9508-7135d6015d82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:488","original_object":"UniProtKB:P35348"}
{"id":"7cb4d708-5a70-4184-ac1f-c5e91f77081e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16135249","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:c82a6fe5-dcd4-447c-bbaf-788c5069c12b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6244","original_object":"UniProtKB:P25090"}
{"id":"8032060e-d9c3-4c68-a2a0-1bbfed7f4105","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122181321","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:d8702052-41a0-448f-9239-c93485756e2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11262","original_object":"UniProtKB:P30550"}
{"id":"a6f27beb-3ba2-45e2-a6af-7bdd4734ea0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:5944ea49-3ac3-4ce5-bfba-fbd9e077132c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P30875"}
{"id":"9a79e078-290e-47b9-9ea4-c3e8ae3aada0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:24145","sources":[{"id":"urn:uuid:30857cb8-daf0-416f-b7d6-8ab62f764ae5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q96RD7"}
{"id":"212815c3-abc0-496b-abe8-1908f3d616fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66775043","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:d0c01f0c-ac2d-4c20-ab18-491356842991","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9499","original_object":"UniProtKB:Q92633"}
{"id":"017a9588-b6af-4c03-bccb-2b359cf0ef0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6129","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:320783ed-ad90-472c-a28f-4cfdb718d116","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6661","original_object":"UniProtKB:P23219"}
{"id":"56a0b600-27ef-4bb7-8751-4378f47f383e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277841","predicate":"biolink:affects","object":"NCBIGene:2863","sources":[{"id":"urn:uuid:112228fa-19b6-449a-8c45-ed20aef9baeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7803","original_object":"UniProtKB:O43194"}
{"id":"c212c95a-9fa8-4b15-b4d1-005190ca452f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:da907717-693e-46d8-ad35-63e8a6629b24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2344","original_object":"UniProtKB:O14649"}
{"id":"53d0d352-b722-45a6-8a1e-60a4fd899201","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60325","predicate":"biolink:affects","object":"NCBIGene:8711","sources":[{"id":"urn:uuid:e57f8e9e-2e29-4e79-8af4-8717bf1eb67e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8057","original_object":"UniProtKB:Q13470"}
{"id":"e12dcfb0-293f-4fd5-b1c1-0426a5cf7d12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1865","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:fb8ba08b-7612-4f07-9b79-e7ab37e1e00a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1865","original_object":"UniProtKB:Q8NFJ6"}
{"id":"349d52ea-8777-43f7-ab80-655a890dd17b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53346504","predicate":"biolink:affects","object":"NCBIGene:10196","sources":[{"id":"urn:uuid:596e14ac-94bc-4a76-9374-7173976993b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7032","original_object":"UniProtKB:O60678"}
{"id":"123f7ebf-5e1f-4faa-833c-e2c3e78b0cd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1114","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:100fc1ab-c23b-4521-af50-7dc8eb7bf98c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1114","original_object":"UniProtKB:Q02644"}
{"id":"4d3a5dd0-e0eb-4472-92d0-d40b6478535e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847194","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:5cb05603-7b5b-4c20-bc37-a38dc59b0b03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:16","original_object":"UniProtKB:P28221"}
{"id":"0a46037e-1578-400a-b497-a7ef2e40b700","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24180510","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:37fde4b7-520a-4493-a516-3857023f52e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6443","original_object":"UniProtKB:P31424"}
{"id":"d76d1161-fdca-4406-b52f-15b3a539b33e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47458","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:bae97b2e-26d6-4b56-bba5-a96fa32a900b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7731","original_object":"UniProtKB:P00519"}
{"id":"30531fc7-cc4a-4811-805d-16e7d6c7a64d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553166","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:19215eea-be8b-4c69-8287-6dd5b969ad1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10292","original_object":"UniProtKB:Q9UL62"}
{"id":"11f33cac-ca0d-4b03-89da-f943fce334a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168255584","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:e77c62f8-2ad8-4396-9b61-9cb144d8e43d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13346","original_object":"UniProtKB:P42336"}
{"id":"c30be3a3-9f78-4d06-aa0f-e4ba6cdf1864","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69636646","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:c6251506-6911-43ef-b1a5-911d06178bc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4246","original_object":"UniProtKB:P39086"}
{"id":"f0987e94-bb23-486b-af5d-358efb50d496","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:14401551-2a55-4d69-b723-15ca6d4f2eee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:343","original_object":"UniProtKB:P11229"}
{"id":"afe0f767-a72e-4266-b8db-907ebd721367","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:83481Y1YCX","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:ae589fd7-1bbf-4c23-a68b-d55d187d09f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3924","original_object":"UniProtKB:P08908"}
{"id":"041615bd-f5ed-447d-a17f-1d4161a84070","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XZ73ATU8W7","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:eda66b23-e3d8-4fb5-99ca-6e44b5067972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5950","original_object":"UniProtKB:P24941"}
{"id":"e3ccd6e4-d0f9-4a74-a176-e87d4e4191af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GKF8S4C432","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:d295e470-efaf-425f-97e7-feb9b9fa28ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9601","original_object":"UniProtKB:P17948"}
{"id":"a0e0b414-dae7-4c90-bc24-ae6ad3bb080c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71311666","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:8237dc81-9301-40b5-88d6-2a7cecd3c152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1457","original_object":"UniProtKB:O43193"}
{"id":"d4a91313-498a-405b-b94b-45587ca737b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:141754136","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:62837ce9-7868-42b5-b922-83c115785664","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11204","original_object":"UniProtKB:P42338"}
{"id":"a1ff4b17-bf2d-41d9-acb9-8e44e21e8e48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189649","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:c2b95bef-473b-4ab5-972b-98bd3c63c67e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9456","original_object":"UniProtKB:P55085"}
{"id":"027dbcc5-662c-42fe-a643-a97e243c1f92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CI43QFE22O","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:d90e7029-a320-440b-8d30-9ddcd7faaadd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11277","original_object":"UniProtKB:Q13315"}
{"id":"77186c4a-da9f-4166-bd75-d8731c940bbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:f2478b30-c88e-41da-b85d-b8d1115a8c26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P0DMS8"}
{"id":"1f874342-82c8-4c65-8c18-75954ff5ebb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71543230","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:2dc535c3-bf94-427c-9a58-ee6e705b2b71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9941","original_object":"UniProtKB:P43405"}
{"id":"ddf228f4-a156-4a04-a0eb-b2b0602a2435","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85403","predicate":"biolink:affects","object":"NCBIGene:23890","sources":[{"id":"urn:uuid:0b61e3e7-1fee-49fc-9acf-d5a68d1d2653","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4064","original_object":"UniProtKB:Q9R1K6"}
{"id":"f972d169-c072-464c-8b1d-9c49407decf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2702","sources":[{"id":"urn:uuid:bb3917c9-3d46-474a-ac5c-11a57ebfaf4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P36382"}
{"id":"3c44e63f-e9e5-4a9d-b13c-e25be2b023fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1700","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:4a74f5ea-41ca-40e8-9ab7-b212ca0601d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1700","original_object":"UniProtKB:O43614"}
{"id":"4ad627ae-0c8e-46d5-b29c-fa3f620ca16c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13305","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:e8199afd-0451-445b-87ee-d6d20b1e20ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13305","original_object":"UniProtKB:P07766"}
{"id":"355acb44-dad3-42a4-991e-8f7d9a8ff545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23654676","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:18da27f9-75e3-4e62-973a-f659ceb5c32d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6072","original_object":"UniProtKB:P21731"}
{"id":"7c260f56-9195-4cf1-a26c-c19004e45ae6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58265877","predicate":"biolink:affects","object":"NCBIGene:2645","sources":[{"id":"urn:uuid:8557b468-5271-476e-a5c0-bcfc82fbd13c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11932","original_object":"UniProtKB:P35557"}
{"id":"abedd9fe-7789-4284-b492-fb26c190cc49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15554","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:eb5dfd28-1995-4e28-9292-1334bef03864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1972","original_object":"UniProtKB:P21731"}
{"id":"b9e64179-a66d-48eb-8ea6-7c7871757d35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134210715","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:30051273-d594-4426-a286-3e20e7f914af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12153","original_object":"UniProtKB:P51679"}
{"id":"70e65ced-4472-4329-a5e3-394e2b202a71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2035","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:09a7ae28-2074-46cd-9fb4-5e4a324bf534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2035","original_object":"UniProtKB:P30935"}
{"id":"a467dbc4-de80-4822-ab49-ec3eaa05f100","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4236420","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:4b61bbbc-2a42-43e2-8328-a7e0553f2fd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3359","original_object":"UniProtKB:O15303"}
{"id":"9a558840-5680-4c0a-8126-da7137932dfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46226500","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:735317b3-a0d0-4139-9773-564b79249006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4011","original_object":"UniProtKB:P32297"}
{"id":"0b90f2e9-3303-4a28-b09e-1e28f576e596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9976563","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:ae71eaaa-4823-40b1-920e-68a747968c1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5588","original_object":"UniProtKB:Q5NUL3"}
{"id":"40de2620-9470-4e7c-bf27-bc5d44ae4fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:da7d210f-4200-45e0-bd5e-80d4ac617b1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P28334"}
{"id":"3c7dee51-bfea-457f-b001-753b24e52568","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:895f69a9-8266-4c46-9049-122e54c852f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P32305"}
{"id":"d76d76b9-4e28-4d52-adab-3b6349079f39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73010930","predicate":"biolink:affects","object":"NCBIGene:11176","sources":[{"id":"urn:uuid:fbac3ccf-cd7f-40df-b01c-fa4e6effb96c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8233","original_object":"UniProtKB:Q9UIF9"}
{"id":"bb54216c-a8da-4346-9d3d-0e03af63db59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5473007","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:01bf6edf-aa07-432f-a7ee-e82fae7b5af0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3192","original_object":"UniProtKB:O95749"}
{"id":"b3310ef3-2f1a-44d3-b6e6-8a3b835302c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:36295259","predicate":"biolink:affects","object":"NCBIGene:321019","sources":[{"id":"urn:uuid:d777ab14-7eef-4348-9ba4-9067cd77f290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13052","original_object":"UniProtKB:Q3U6B2"}
{"id":"6796b839-31d7-4417-a879-0665e107c97a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:5613","sources":[{"id":"urn:uuid:010bb88d-950b-49f1-a183-24d42ca500e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:P51817"}
{"id":"3336be4c-2763-413e-9c9c-5022e80d21a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817437","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:0441a26f-0e61-4968-8853-ebbdf3bd103b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2268","original_object":"UniProtKB:P35000"}
{"id":"068725cf-1eb3-4807-bbc9-5d2e654b20d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90685","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:097dcac2-39da-44dc-90ec-fcbcae7107f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9915","original_object":"UniProtKB:Q15759"}
{"id":"352eb77d-1c07-4a35-9094-9026e3b0f887","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11535913","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:d5b33505-267f-45fc-9d1d-cf02e8783a03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1428","original_object":"UniProtKB:P41594"}
{"id":"943d77e2-2465-46ef-b1b3-daf58d019aa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:bd1aa4d4-3e75-412d-9e65-3714a4773780","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P30542"}
{"id":"2de79acb-4bf1-49c7-adcd-e22b69466c60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59299562","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:290503c4-62cc-4017-b871-4283fc193516","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13558","original_object":"UniProtKB:Q8TDS4"}
{"id":"d2693458-c7a8-4632-a70c-e7d0a1f77baa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452041","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:f2817b88-4469-46c0-a3d4-667b136de2a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9189","original_object":"UniProtKB:P41145"}
{"id":"0756620a-7176-4efc-9464-3bd364dc2454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3223","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:12f6c414-8636-4499-8899-b4a262fe6518","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:36","original_object":"UniProtKB:P32305"}
{"id":"52f83620-82f7-43e2-88dc-e52c092356f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:348980","sources":[{"id":"urn:uuid:47899313-a67a-431d-a372-04b37e5d214e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:O60741"}
{"id":"eac275c6-c324-4049-ad84-27c3a5d137ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71737672","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:2bccceac-f6d4-4b27-b413-f44fabfbe0d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8687","original_object":"UniProtKB:P08912"}
{"id":"28621e78-08a8-4c38-9824-a5c59bad374d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44589122","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:839daaa0-5601-494f-8ef6-93b7a2cb1c52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11815","original_object":"UniProtKB:Q99685"}
{"id":"33567e34-308c-4b61-90f9-e509aa3bc699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3260619","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:58f5fc72-4f9e-4fad-9756-7b215d778d8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6227","original_object":"UniProtKB:Q14833"}
{"id":"65eb22ad-a3e4-4cbc-9050-20d1ea791974","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8586","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:01ee7c30-55d5-4098-a76a-87f3e33c4829","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8586","original_object":"UniProtKB:P08173"}
{"id":"b8377a17-64e5-4c44-9f2e-842cba2d74aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4FR53SIF3A","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:7ba9ed08-9867-46a3-b56d-0900f07358f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7384","original_object":"UniProtKB:P07766"}
{"id":"d2536af3-089e-4445-a36d-244eb1553b78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:585948","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:ba454ee5-6334-4e1c-8d4e-9a6624a9f774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4190","original_object":"UniProtKB:P13569"}
{"id":"48e11b0e-dabc-4891-8d2a-78d3163567f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:8a495b2d-f859-4bf5-9f99-01d5dcb35e9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:P32745"}
{"id":"180d9441-952c-4bf3-88bd-689dbdc7fe2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:3472864e-2927-44ff-b492-e1a5f2e030d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P10980"}
{"id":"8f4a98f4-e5ac-469b-83cd-a5884ba70d9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393290","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:fc381056-7363-44f4-b778-950855c11c5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10388","original_object":"UniProtKB:Q13546"}
{"id":"daf3f289-d136-49a3-af2d-7af9d1739dda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4W3KFI3TN3","predicate":"biolink:affects","object":"NCBIGene:55507","sources":[{"id":"urn:uuid:1bf50b60-b96c-461c-a37c-91aca5e784fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12240","original_object":"UniProtKB:Q9NZD1"}
{"id":"91afd578-a059-4b47-89d5-a4d8d0e4feb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94777","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:2c5bd04e-ee14-4cfb-9022-102cc6ec6703","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7556","original_object":"UniProtKB:P21917"}
{"id":"7c208359-6ddb-4cdb-9318-1b63e449f062","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030520","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:b685f809-08b7-46cf-9934-633a2c02f476","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10428","original_object":"UniProtKB:P12931"}
{"id":"0e28c547-a56c-4f20-b2f6-dab21626dc5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42628843","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:7fb8ca73-9646-431d-b51f-d79717fcce46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9815","original_object":"UniProtKB:P15056"}
{"id":"dd5ff1af-dceb-4c1d-8bbb-8ed73d4b658f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841284","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:2044c1a0-f24a-455b-a318-cb82a4cd005f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:423","original_object":"UniProtKB:P29274"}
{"id":"05fcf64f-b587-4afc-bf33-dc7fcd416463","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53459","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:ff468c24-bb72-4470-9492-d5ac6bf5aacb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2468","original_object":"UniProtKB:Q8R4D5"}
{"id":"fd417b75-519e-4893-9f18-4b27cb74713c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3171","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:e60ed79e-29c4-44ea-be9d-8701f12340a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1603","original_object":"UniProtKB:P41143"}
{"id":"bd9f0ee2-fe32-4ee1-9eb8-989ae6a8b380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64213","predicate":"biolink:affects","object":"NCBIGene:5515","sources":[{"id":"urn:uuid:ecb23e2a-32e9-466d-999e-b5a4e73c0679","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13081","original_object":"UniProtKB:P67775"}
{"id":"5996c9b7-122f-4699-bd8f-2f21792f5267","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194340","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:b47ac761-3043-46d4-9e32-ab95c4425904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12647","original_object":"UniProtKB:O43497"}
{"id":"5f449b25-5d44-4fc9-9e18-8f2294e523a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91820714","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:612d7fc8-a3fe-4b38-9b04-82fef4e02ba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8637","original_object":"UniProtKB:P15121"}
{"id":"50b9e462-c69b-4924-a372-f94b2d8be726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3700","predicate":"biolink:affects","object":"NCBIGene:55366","sources":[{"id":"urn:uuid:f7db8589-635a-4d87-97cd-a607c395c3e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3700","original_object":"UniProtKB:Q9BXB1"}
{"id":"d60c4995-bb38-4b3a-9118-d525e3a10a9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175901","predicate":"biolink:affects","object":"NCBIGene:6241","sources":[{"id":"urn:uuid:6a543b5f-3708-4cb6-8033-9f2aefff11d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4793","original_object":"UniProtKB:P31350"}
{"id":"f871b63b-5924-4750-80e9-7a3c3dee494d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57381112","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:fb194708-480e-4703-bc09-773fbd9a91c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7776","original_object":"UniProtKB:P48039"}
{"id":"e60de1c9-1c16-44d8-b4db-787038b99f5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86007","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:8715af5e-c52a-4651-8352-cc9f0914d037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5938","original_object":"UniProtKB:P06493"}
{"id":"9fc6fc0c-8972-417c-a29a-fc56d525d50c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93291","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:26681990-59ea-474c-88c1-442e75fda1a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11691","original_object":"UniProtKB:P41145"}
{"id":"86fa4c2a-6890-40ca-8813-0b902b711491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17115","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:a81c6d89-6725-476a-8dbc-38b90a6f0db7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4171","original_object":"UniProtKB:O15399"}
{"id":"0db489a6-05a9-4378-b6e2-001bee3767db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117807031","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:266916a4-3be2-4aef-803f-dd6683f4900f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13203","original_object":"UniProtKB:P15056"}
{"id":"dc8a78bd-470a-4aed-9e67-e0bc43a38e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947094","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:9e9ca00d-077b-4e0f-9b73-8eb8890126b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3392","original_object":"UniProtKB:Q8TDS5"}
{"id":"e385bd03-f0a8-4f69-b74d-4531f4be7241","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817485","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:dd27cd9d-384c-4a45-a47d-ee8b210931bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6121","original_object":"UniProtKB:P47211"}
{"id":"d322d209-e716-4891-ae5e-035f6b868229","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53396299","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:139664e2-c60e-46c8-a4bd-9f2539712638","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1135","original_object":"UniProtKB:P43220"}
{"id":"11493e40-b8b4-4b12-a93b-00f64fd6ab2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:240107","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:679eab51-c42c-4f3a-98e0-04c3c5e6da12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7131","original_object":"UniProtKB:P23219"}
{"id":"1a2e432c-9f1b-4274-88bd-a7256c07b10e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E0OU4SC8DP","predicate":"biolink:affects","object":"NCBIGene:495","sources":[{"id":"urn:uuid:8d0a4cdd-8e3b-4685-b294-5ccc85046b29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13761","original_object":"UniProtKB:P20648"}
{"id":"734ce0d0-ddc0-4573-b959-3d7b4713bb20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0P934RSF8B","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:527f4cd6-decb-46e3-a757-5aaa006900cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1381","original_object":"UniProtKB:P23385"}
{"id":"c2eb8f06-0d49-4e45-acb6-1832847cc2ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71774987","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:b1818800-2569-469f-bee8-cff68f79f1d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1668","original_object":"UniProtKB:P34975"}
{"id":"cfc6f6e3-e198-4870-b7c7-fe3b9d9ca16e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40953","predicate":"biolink:affects","object":"NCBIGene:5603","sources":[{"id":"urn:uuid:e009f81d-4053-4d65-8534-fdd07f24a63c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5668","original_object":"UniProtKB:O15264"}
{"id":"9bac8094-af65-4739-b1d6-bc8ae64677b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92326","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:74f57785-945a-4671-80e4-577749abd591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3505","original_object":"UniProtKB:P47871"}
{"id":"e1259eaf-10a6-41b5-8352-4da7d18d30d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27960","predicate":"biolink:affects","object":"NCBIGene:4846","sources":[{"id":"urn:uuid:56ecb7ee-59ae-4bf3-8740-219d9388ed8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8759","original_object":"UniProtKB:P29474"}
{"id":"146c8acd-61d2-4474-b52c-3f5e6c5992b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91970993","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:6c0575c2-4053-432d-a2e9-c00c415e6ebf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3792","original_object":"UniProtKB:Q969F8"}
{"id":"b2048b18-e07e-4c6c-99da-a50ad06d280f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:db0e97a9-aeba-473e-9758-444160f1a61f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P08913"}
{"id":"a5de8d6b-6329-4949-a3eb-755efe7b8b8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72709209","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:461378f0-9dbc-466e-9b4a-393b75a39fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9353","original_object":"UniProtKB:Q8NEB9"}
{"id":"a68cf126-2052-4d04-86e9-277ba921a53e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90531","predicate":"biolink:affects","object":"NCBIGene:5583","sources":[{"id":"urn:uuid:d81d4444-c695-43ce-85d6-20de3f0413f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7946","original_object":"UniProtKB:P24723"}
{"id":"2bcb102a-5c8d-45d1-9954-cac9a4aa50c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31174","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:c5606e81-0fea-4550-b3e8-e1a2d1b3c57e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5429","original_object":"UniProtKB:P10826"}
{"id":"eba29a8d-da6e-47dc-a654-8411b8e46b9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74015851","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:fdb05b25-7994-407f-99e9-51780953771e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5872","original_object":"UniProtKB:Q92847"}
{"id":"ecfbd97e-878a-4fd8-9a2e-251c8b8dcb29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:877df103-147c-45d1-bb2c-e1da859de1af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q8WUI4"}
{"id":"dc482e78-9e1b-44c4-bc3f-ea52a765fea5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132316","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:da4c5059-cf44-45f6-9998-fb13ee555e4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1643","original_object":"UniProtKB:P41143"}
{"id":"211e5ae8-82f1-4af2-a72a-f4caaf699838","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311330","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:b6716e34-7838-444d-b260-bdde3730a5be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4271","original_object":"UniProtKB:Q12791"}
{"id":"b168d138-6c57-44ae-b21e-c3d1f7d62679","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7037","predicate":"biolink:affects","object":"NCBIGene:55170","sources":[{"id":"urn:uuid:02c116ba-bf5f-42f8-94df-b0b3b21710ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7037","original_object":"UniProtKB:Q96LA8"}
{"id":"62255e9f-9d32-4b61-854d-ce2c5574a12d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53443082","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:87d09310-4598-4531-8d7a-b066cf45ab35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6272","original_object":"UniProtKB:Q8BLA8"}
{"id":"9b5f04fc-5216-47ed-a80b-f34f6012f472","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:9ae11a32-d125-4f87-b798-2fb91529e3b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:P08235"}
{"id":"4ce09d67-c62b-49ce-9e19-b5161a3dce3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MZ37792Y8J","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:16ecf25e-c2ae-4925-9fbd-2b42f02f4d6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8739","original_object":"UniProtKB:P28074"}
{"id":"d530dbbc-2700-4d9b-940b-3239b02ce02f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:ef540663-2f59-4add-a284-d6b882cf63b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P06241"}
{"id":"5a1a6a57-0181-48d7-ad80-ec69da239ec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZRH8M27S79","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:6ef46358-e2b8-47b9-95a0-41376caa32cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6271","original_object":"UniProtKB:Q8BLA8"}
{"id":"7cf46713-01d9-4bb9-af40-ba6f538b9038","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:e86b55cd-5cc4-4c2b-904e-8ec7fe6006f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P61169"}
{"id":"f80a7cc4-b6b2-49c2-8af4-5c947983c6d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:168543","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:c0ccc723-b25f-4a9b-b59a-38068f58e97e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1930","original_object":"UniProtKB:P30557"}
{"id":"17e17c4b-ef78-46ee-bd0c-24d41f2b7449","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64119","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:43f7cee6-5a5d-45d4-ba3c-d9b4a1058071","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:958","original_object":"UniProtKB:P35462"}
{"id":"53b4be7d-1d0d-497e-a01c-d32fd4b90712","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91091","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:4cb9c9b7-5cfd-41eb-9c40-d4f5985a147b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8014","original_object":"UniProtKB:P28482"}
{"id":"21fd60ab-d759-4e48-bcd0-abd8784718cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93272","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:08e77dbf-fecb-4273-9e93-57c2908242ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5565","original_object":"UniProtKB:Q9Y2T6"}
{"id":"e6d6f852-2bc5-41f5-a661-51075710e0d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131156","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:b4b86c6e-2fb7-4a45-9a2f-b35a82042a1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7713","original_object":"UniProtKB:O14757"}
{"id":"51a7d030-a1f6-4f9d-80de-1b0892418739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7640","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:df21a7df-87a0-4adf-8111-983aff9e411b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2404","original_object":"UniProtKB:P48545"}
{"id":"94505b51-3d01-4305-92e7-156b2943fb43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167693","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:3b300aac-ad0d-44ce-9d2f-749a3fc5905e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8240","original_object":"UniProtKB:Q15910"}
{"id":"0999beb6-2da5-495d-becb-beb582fb7994","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34969","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:e58e5c28-b4b0-4eb9-a19a-812d33a06d74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3533","original_object":"UniProtKB:P34998"}
{"id":"b1d7d867-c662-4c20-9691-29019b979c7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:8e13e7af-f7ff-4c09-99aa-0a8149a1887c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P43117"}
{"id":"4fa70d90-1d62-40d1-bf34-5fc2342206c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:865UEK4EJC","predicate":"biolink:affects","object":"NCBIGene:6555","sources":[{"id":"urn:uuid:a04cef16-5d2c-4c53-9ce2-5912eaef6328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9996","original_object":"UniProtKB:Q12908"}
{"id":"d633934a-d906-4526-83b2-e70655ae14ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827340","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:2ee9bfec-2d85-40c8-b5fc-25b94fb4c877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:527","original_object":"UniProtKB:P18825"}
{"id":"f6dd6a8b-fd31-4d9c-b491-89caa07fc9d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36259","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:9a604a79-a60f-4158-b15c-fe340bcb2f7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4548","original_object":"UniProtKB:P59540"}
{"id":"b3ec3b73-8920-486b-8b4e-f053947d3b4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:04eb72c4-59bd-4683-9ec8-dc42e824ebb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P21918"}
{"id":"04a7caca-4428-4ee1-90b9-d0074f3bf40b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27999","predicate":"biolink:affects","object":"NCBIGene:3764","sources":[{"id":"urn:uuid:4d99571b-f8a9-4af5-9ccd-baf1b3352398","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6848","original_object":"UniProtKB:Q15842"}
{"id":"612d084a-62a7-4347-87c7-6caa243ac79b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91522","predicate":"biolink:affects","object":"NCBIGene:24174","sources":[{"id":"urn:uuid:d61b9433-ee8f-4938-81a7-0e0e19085373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3470","original_object":"UniProtKB:P19328"}
{"id":"345f400b-c77e-49b1-a3ac-c7e8f3d810f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324619","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:99383131-afa8-4b79-a982-dd527665ee75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6513","original_object":"UniProtKB:P30531"}
{"id":"2cf72fb6-1a8d-4940-aaa0-3c4d821abee3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10426487","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:6de6b970-5d09-4bd5-bdb3-ecddb48fc5db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:291","original_object":"UniProtKB:P08172"}
{"id":"d70a2bc7-9437-4dbf-8f90-06d827dd97b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1690","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:81249df3-23ac-4cf3-8f3a-7710562851e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1690","original_object":"UniProtKB:P41146"}
{"id":"db92fc79-386d-4c71-ae55-b466f26d2203","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F89KMM7TE2","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:afbc6dbe-f2d6-41a0-8a70-4cce92d49169","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8037","original_object":"UniProtKB:O75116"}
{"id":"8bffcb63-f59a-4335-b74b-4e2d0e910bf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4657","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:f1a28d5f-1b4c-4783-9be4-65d902bfdf38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7167","original_object":"UniProtKB:Q12809"}
{"id":"18fb35a4-4b5c-48c2-b5d3-dae5c3934bc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DRZ23E4F7","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:6b6af8a2-0f6a-48bd-adbe-b34edc4669fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5619","original_object":"UniProtKB:P25099"}
{"id":"6b5be73a-7970-44e9-bf07-e392fdf289f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8499","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:95739ee3-95da-475c-8f1d-81d2ea47ce3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:564","original_object":"UniProtKB:P25962"}
{"id":"fed41b4c-7a98-4a74-955e-0ed9fa7e791f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2613","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:107a4f0a-7ab4-4d26-9bfc-3b35644072fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2613","original_object":"UniProtKB:Q99250"}
{"id":"a11ca9e6-c432-4250-aed7-62cecfe51839","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52172","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:1f389a94-6c14-4cb7-85f3-1f5a5f4c5ec9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5697","original_object":"UniProtKB:P00519"}
{"id":"3c65b73b-5024-44ec-9737-66805b7e3568","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107736","predicate":"biolink:affects","object":"NCBIGene:13489","sources":[{"id":"urn:uuid:a77c81d1-1cd3-4f69-87f5-890eb5413113","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:241","original_object":"UniProtKB:P61168"}
{"id":"622201d6-b541-446a-8285-a0b03e832d11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177398","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:78f4c3b7-9863-41bb-87a0-8bfa8480df67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5605","original_object":"UniProtKB:P29275"}
{"id":"6f540078-e20b-4399-821e-32896542a818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2045","sources":[{"id":"urn:uuid:a445bd22-1088-483a-967e-e5cc4b266a90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:Q15375"}
{"id":"565e1203-f418-4b6b-92a3-e3321e250c30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2219906","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:5ef1f004-dd56-4701-a598-b372d897b836","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6715","original_object":"UniProtKB:P48449"}
{"id":"c6890940-e5ce-48b2-b151-d21b35942f6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B2K5L1L8S9","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:b897b582-8b54-463d-9323-cde99108f573","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9769","original_object":"UniProtKB:P35968"}
{"id":"ba9c7877-6286-4ac0-9738-3ce4a2b89cbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DLE8519RWM","predicate":"biolink:affects","object":"NCBIGene:81607","sources":[{"id":"urn:uuid:a826597e-56a2-4906-9772-2375502a4a85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10738","original_object":"UniProtKB:Q96NY8"}
{"id":"bf12da11-0691-454a-9f9d-f474b82ff086","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:859","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:07674a97-8604-45e8-8fc7-70ee295f2309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:859","original_object":"UniProtKB:P30551"}
{"id":"f89ea8e3-f6f8-45f3-a1eb-1d40bb606fed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92844","predicate":"biolink:affects","object":"NCBIGene:7486","sources":[{"id":"urn:uuid:ee4390da-299e-464d-bddf-b1d43e0ba510","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13026","original_object":"UniProtKB:Q14191"}
{"id":"6dd976a9-a4f4-4bd1-ba25-d0cf4ce1eed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121415134","predicate":"biolink:affects","object":"NCBIGene:8564","sources":[{"id":"urn:uuid:38dea47b-b650-4345-9197-d3caaab8d5b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10358","original_object":"UniProtKB:O15229"}
{"id":"22ae9449-405e-4dc1-adcd-62f1fd92dedb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17688","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:3ac6adc0-84e5-45ec-8d08-5e5a989ec570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2585","original_object":"UniProtKB:O75762"}
{"id":"14233ffd-be98-49cc-8db3-826e83466e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:29713","sources":[{"id":"urn:uuid:13b45bea-9860-46e1-84f0-0349c8985060","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P48548"}
{"id":"5f41a0ee-4260-440d-94ca-b283c463720d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TT6HN20MVF","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:3d9543fa-f630-4c32-b516-399187976513","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9172","original_object":"UniProtKB:P16234"}
{"id":"ffd716ba-7d59-4842-b689-f2ab068bc6e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:5b952e16-9dae-4c3a-a4a4-c6c7661bae97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P97794"}
{"id":"93cb35fd-cf19-463e-a2e1-71acf292cb40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44086933","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:09b37e90-68dc-4fa8-a0e0-48fb34477a16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12608","original_object":"UniProtKB:P50391"}
{"id":"a8fb5f4d-6da2-43db-8364-3fb9d70d9efe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:53944","sources":[{"id":"urn:uuid:42c11e56-1e2e-4cf7-b5a1-6fde62958554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:Q9HCP0"}
{"id":"3089fccf-fd1b-4312-8dcb-1f323d2f8df0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5842","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:280338fa-5cf7-49f1-ab61-25f7457e14a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5842","original_object":"UniProtKB:P21462"}
{"id":"195d4faa-41b7-4948-b92f-7a15ab69acf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9985","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:4b8d6f26-48aa-40c7-abbf-e5896b52e92e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:349","original_object":"UniProtKB:P08173"}
{"id":"da8035ae-f23e-4ebe-8249-d7d9ca27fb76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:624","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:224e850c-8e81-42bd-be86-3637ea2770d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:624","original_object":"UniProtKB:P24053"}
{"id":"88366b5b-cc35-481a-9035-530cec544e13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:70e760b8-a2b3-4292-a98b-bb23aa9045ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P07333"}
{"id":"8bd0a3ca-941b-4a77-bfd7-f75bef2ce982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030524","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:238a5061-014f-413a-aa70-f66a71183d93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10443","original_object":"UniProtKB:P30542"}
{"id":"7790f56d-02c6-46df-9a0a-416295a96a5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184771","predicate":"biolink:affects","object":"NCBIGene:10257","sources":[{"id":"urn:uuid:ced4efba-b5c7-457d-b254-0b37580fdcf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8802","original_object":"UniProtKB:O15439"}
{"id":"0519e74e-9b8f-4b31-9b60-b3b28eabb7fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232383","predicate":"biolink:affects","object":"NCBIGene:84444","sources":[{"id":"urn:uuid:9320aff6-9f58-4e18-b674-2e97df5b09c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7020","original_object":"UniProtKB:Q8TEK3"}
{"id":"74394922-f0a2-46e2-a537-b1b24220077c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131512","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:148d1d7d-dd5b-44bb-a9d7-7412c3e599c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5281","original_object":"UniProtKB:P21397"}
{"id":"281bf480-ecc1-4e16-bb58-82cc65c8081d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114756","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:aa7629ad-c945-4752-b76c-2bead50ed2e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4078","original_object":"UniProtKB:Q12879"}
{"id":"6cce9960-03ca-4035-b565-bd18dc6564ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93452","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:21b99c9f-55e1-410b-9ff7-a1498310a65f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4296","original_object":"UniProtKB:Q16445"}
{"id":"c00db560-6bc6-431e-84d0-54364335411a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:196416","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:355e5030-ec27-4980-896a-73e0b3b54bf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1715","original_object":"UniProtKB:P47900"}
{"id":"a494ac56-94af-45aa-9b36-1f0675251d07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11546","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:d9fa14cf-c053-47fe-8755-7dc4dc24c036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11546","original_object":"UniProtKB:P22455"}
{"id":"d65989f3-f7d6-4573-8b92-b20325bea599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1HLS600135","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:9d5095a6-6051-41fc-99f1-5b22b1215afc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:489","original_object":"UniProtKB:P25100"}
{"id":"b3025c20-fba4-4606-891e-adfbd80ea601","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699449","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:c78c7ad9-8ea8-48b0-8ebc-510365d1f91e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11146","original_object":"UniProtKB:Q9NYA1"}
{"id":"76dbc79c-d595-4c71-baf6-2167d02afd75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:20350618","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:63be09f0-d305-464e-a65c-b9ab10bb9e0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7515","original_object":"UniProtKB:O60885"}
{"id":"f6a56147-784e-45fb-a8d2-f4b784f2f275","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:560e75ae-46a2-4f79-92b6-c3b4ee7d2d31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:P56524"}
{"id":"15bd5ca0-d9b4-4866-bf9e-adb0e0a155f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5346378","predicate":"biolink:affects","object":"NCBIGene:23643","sources":[{"id":"urn:uuid:cd023466-7c11-4462-93b8-af2bd36107ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9027","original_object":"UniProtKB:Q9Y6Y9"}
{"id":"8262b58d-0524-4aac-93b4-506850074962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51211","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:2644bd63-03aa-4170-9bd6-d014eb0f5f0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:563","original_object":"UniProtKB:P07550"}
{"id":"2a10069c-fba8-4bf8-b8b5-15cc64be211d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:deb63119-45ff-4768-a359-407160d1fb36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q9JL06"}
{"id":"2947f770-3ec9-459c-9576-44429fa2d97c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10432920","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:4cf925a8-06fa-4675-b269-47477c34eb4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1722","original_object":"UniProtKB:P47900"}
{"id":"79e7f65a-1515-4b5a-8d5d-c1c7d9da0253","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23928102","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:6bd1dddc-6983-42eb-938a-2d7e84bc6a2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10303","original_object":"UniProtKB:Q8NET8"}
{"id":"67655c18-05c6-4ea5-93c8-f48a29c743db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PW3Q92Z6A4","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:99f7c419-b9b5-457d-abf2-749d07a88b34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11624","original_object":"UniProtKB:P35968"}
{"id":"25a663e9-0326-46cc-96ea-aba70b763228","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68181876","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:d8ceb432-2faf-4b37-98cd-3dfb656554e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8941","original_object":"UniProtKB:Q13153"}
{"id":"ee7aa9a2-4121-43f0-8792-3f3820a3177e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8bb2c189-db6b-410e-8e7f-f3b6739edc95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8593","original_object":"UniProtKB:P08173"}
{"id":"0390040c-6d31-4cf2-be2f-5e6b52c8a51d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2534","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:11643406-76df-4e89-b81f-b048597cd83a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2534","original_object":"UniProtKB:P54282"}
{"id":"67ffa3ee-dfe9-4e1e-99c6-b601588a7939","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:95dffdd9-8a72-492d-a869-e551ac69bb48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9UL62"}
{"id":"9d0fca4e-7c1b-48ce-9e94-4929a0a211b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9863759","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:20a31abe-ee56-4b9b-81a0-9ade387332e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8886","original_object":"UniProtKB:Q05586"}
{"id":"697b0a1f-a304-43d5-bf7b-b8acd3e86797","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11847343","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:8cf8a49b-3b52-4eb7-aad6-8e63d307d233","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8768","original_object":"UniProtKB:O14965"}
{"id":"a4c63822-61f6-43f6-ab61-ee8e13d340e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118877241","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:39ac60bf-206c-4770-bd62-9f7a0d8c94f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11494","original_object":"UniProtKB:P21453"}
{"id":"f2e4a872-5a75-47a3-86d6-cb16f1b39767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50859","predicate":"biolink:affects","object":"NCBIGene:6258","sources":[{"id":"urn:uuid:9be62a5e-b4ce-4a10-adfb-abc1f51b22ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2807","original_object":"UniProtKB:P48443"}
{"id":"ecfddb82-f1cf-44ae-810b-3ba361598089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34823","predicate":"biolink:affects","object":"NCBIGene:16535","sources":[{"id":"urn:uuid:37c4a32b-ff27-46fb-9085-b5bbfebe8476","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2599","original_object":"UniProtKB:P97414"}
{"id":"e5417372-b041-4df3-a440-15c5ad9635da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9905541","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:032e5744-93c2-4fee-bf25-7214d321a62a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3067","original_object":"UniProtKB:Q02769"}
{"id":"70c37e00-3302-47c6-8564-d6b4d2f8aaab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135261","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:7f6d78dc-df7c-44c4-9aab-86f3d9e6b4df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:569","original_object":"UniProtKB:P13945"}
{"id":"23cc1c36-f546-4ec5-a110-6c262e959a4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5441","predicate":"biolink:affects","object":"NCBIGene:16514","sources":[{"id":"urn:uuid:71925325-d41c-47b5-8b60-2128864b531e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2414","original_object":"UniProtKB:Q61743"}
{"id":"91ba98b5-6d34-4123-8213-a35c6de60a7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18152","predicate":"biolink:affects","object":"NCBIGene:7153","sources":[{"id":"urn:uuid:a06851b1-37d1-451a-af9b-d3e03d9cc85e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13074","original_object":"UniProtKB:P11388"}
{"id":"1a1fe350-ede4-4a16-b9b1-37cedbc28596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSZ0E9DGOJ","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:2f29692a-7440-4a25-989e-a3c91eea4f54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4146","original_object":"UniProtKB:P47869"}
{"id":"a118aafc-16c4-4b07-9f98-42b06c58eaae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188757","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:38181ef0-71fc-4889-8a92-aa9df9ea7f46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7909","original_object":"UniProtKB:P52333"}
{"id":"6f06b64b-f147-43a2-b332-475095141f29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:3399eea6-555c-4424-9850-fab5f2fc6c42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9UBN4"}
{"id":"8d90f798-47f2-4221-8656-2875a4b420d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44275230","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:46cd374a-eefb-44f6-8afe-429d23d50390","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3105","original_object":"UniProtKB:P37268"}
{"id":"627e1012-184b-46ff-95eb-051c270e7f3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90865","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:176546f0-ae57-43a0-81f9-a51e9d6542f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8182","original_object":"UniProtKB:P28223"}
{"id":"86d880c4-787a-42ef-b243-7bbb564a2a25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:8b39504c-726f-4944-80d9-43204d86817e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P14416"}
{"id":"c8abece4-d988-4919-bd13-b63a7c11cb81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86390","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:9b5780cf-555c-4e02-a01f-ac6933dff41e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1590","original_object":"UniProtKB:Q8TDS4"}
{"id":"94187925-1830-4bd7-b8d6-c20166633f9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VFC23V742Z","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:9ed27947-a6fe-4f5c-88a7-39a9191af06f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1619","original_object":"UniProtKB:P41143"}
{"id":"e322147a-b2f9-492c-a46c-3b8c93d94f5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6710","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:24b41128-4f87-48d0-a58e-a1e71a1d8dca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7219","original_object":"UniProtKB:P23219"}
{"id":"ea8317fd-8079-468d-be9a-d63480a5b572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5307","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:62371b3c-9d0b-46af-9c71-8016b9fc8ce4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5307","original_object":"UniProtKB:P20789"}
{"id":"d3753196-e393-4da0-856c-af616fa4a0ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2215","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:5347a13e-2b6a-41b8-b54d-8f0024da0206","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2215","original_object":"UniProtKB:P37288"}
{"id":"ceed796c-0dac-430d-9d96-6add2b4da22c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6420161","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:d9bcdf49-a41c-441d-9321-e88d83a989dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4333","original_object":"UniProtKB:P39086"}
{"id":"6d64eda8-a140-4503-9bbc-943b696b58d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:22152","predicate":"biolink:affects","object":"NCBIGene:50832","sources":[{"id":"urn:uuid:b2e3aba8-4d6c-45a9-9cc5-2d3d21d67248","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10362","original_object":"UniProtKB:Q9NYW5"}
{"id":"9d4ceef8-ca4f-4720-993f-49655d35587d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25207521","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:2ff495de-6081-4cbe-8a31-625c7a356a07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8163","original_object":"UniProtKB:O14757"}
{"id":"e3f39315-20a1-4a34-8bb3-ecf428c598f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188765","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:59d54bef-21ed-4f67-8064-8d22198e9eb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6468","original_object":"UniProtKB:P08253"}
{"id":"54d5aa7b-fc80-4866-bd1e-3d39ca5c400d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90620","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:2b7095ff-1c1d-4242-9bab-0bca4def7e64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5705","original_object":"UniProtKB:P17948"}
{"id":"2a2b94e6-f461-494d-9c45-2f70fbad950b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N7T15V1FUY","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:a6d66883-902f-4f74-8d30-8a0006306910","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9272","original_object":"UniProtKB:P32245"}
{"id":"00f6ff1b-da2a-4825-86e1-9b7750bf81b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50922","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:ffd6561c-2d36-427b-b3d4-0bec7a6c1b2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:40","original_object":"UniProtKB:P28221"}
{"id":"473fcd46-3d10-4804-8e10-7e5737b84254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25195091","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:de1d1a15-780e-4070-b55b-b77b4f298c42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5773","original_object":"UniProtKB:P29371"}
{"id":"c5ba298d-03eb-4208-88f6-20342907d304","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:d7859e71-498e-4ec0-8d57-0c081865fe9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P23415"}
{"id":"d85986ff-f5a8-4f0d-9c27-17ba603d6081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5972666","predicate":"biolink:affects","object":"NCBIGene:100359982","sources":[{"id":"urn:uuid:628b4c3b-5922-4eaf-ad50-8772e5496151","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11301","original_object":"UniProtKB:P38718"}
{"id":"36c665af-318a-4a9c-9258-e886e347b057","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182080","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:1f4277dc-588c-498c-a75c-af0e350da82c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1606","original_object":"UniProtKB:Q99720"}
{"id":"7b31a04d-3451-4b04-b5ba-c17826b7205e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:d371a150-8946-45c2-9e4f-05c464be73cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P28221"}
{"id":"64aad9b7-386c-4b12-ab63-4c40753cdb6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7801","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:9241f5e2-4598-4fc4-8c46-15e53cea546a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7801","original_object":"UniProtKB:P35414"}
{"id":"98f7fd5c-0809-4936-a70e-373c35cf9fdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2D9N67F58G","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:77b98734-166e-45ab-bfa6-b3bc8a9c7ca5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5691","original_object":"UniProtKB:P36888"}
{"id":"7c5758fc-5732-4b3f-b87d-d8dcb6a47f36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817482","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:94b71e0c-e3f1-4a1b-b55b-2e2a7f244f24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6093","original_object":"UniProtKB:O88854"}
{"id":"5d1fe64b-b632-4942-8859-2aebb3ef1310","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9665","predicate":"biolink:affects","object":"NCBIGene:8808","sources":[{"id":"urn:uuid:159d6912-d28a-48a7-8f66-a5a09f7d3ff3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9665","original_object":"UniProtKB:Q9HB29"}
{"id":"4f8e0f94-771f-4488-9b1b-c2992ccb84de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:f2a3d578-0d9d-4e94-8c8a-76ebf2ac6eca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P61169"}
{"id":"09651131-33a3-4e74-8092-1dccbcfa15ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3601086","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:e8f959da-57f9-4260-98f9-6fe2a1b5bc25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4294","original_object":"UniProtKB:Q9HBA0"}
{"id":"eead260a-1d01-4630-aa4a-cc610eed55f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185944","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:617c2d1a-0a2e-4b0f-a719-8a123876ed59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6033","original_object":"UniProtKB:O75116"}
{"id":"9d784fc1-eb0f-4002-8644-678b60c6c298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2914","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:4719a05e-04b5-462a-b19f-3bb13b3a5b2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9537","original_object":"UniProtKB:P43681"}
{"id":"e128701a-845f-4103-88fe-cdcb8c9dd1eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63580","predicate":"biolink:affects","object":"NCBIGene:3614","sources":[{"id":"urn:uuid:693e50b3-3e46-4a87-998e-2b3fb55b05c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6842","original_object":"UniProtKB:P20839"}
{"id":"5aac3fbb-c7b7-49f6-83aa-0abaeb2e58f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:8c43b55b-1cf5-44ef-94c7-4e0563b5e4aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:Q9Y6L6"}
{"id":"a7b35c8b-624d-471e-a1ea-afe59c6fbae7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7043","predicate":"biolink:affects","object":"NCBIGene:25153","sources":[{"id":"urn:uuid:1699f958-045b-417d-a2bc-5f3e38d84e34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7043","original_object":"UniProtKB:P12526"}
{"id":"33677f98-e906-4902-b833-eba1311d8707","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:654","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:b5934bd8-6baa-45b6-903e-03672b743677","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:654","original_object":"UniProtKB:P97583"}
{"id":"80aa257c-bf2a-4172-bfe0-033deb4adbed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:a7345354-44a1-48e4-9405-862707714647","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q9UKV0"}
{"id":"6a8e8c40-4fe0-4cbf-9edb-513da5651ad6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:e98b234a-47ce-4541-8879-ae8429ef7830","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:P08684"}
{"id":"b2b49de0-6823-4437-9082-d08b40df1449","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28887","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:18fa7bbe-bffb-418d-ab95-7b4b7e1dcb42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6778","original_object":"UniProtKB:P11836"}
{"id":"cf04e7fb-4475-4928-a64f-d72b02f09f0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:33639WNC7Q","predicate":"biolink:affects","object":"NCBIGene:5288","sources":[{"id":"urn:uuid:9b5ee3e5-00e2-4c3c-9a5e-d429c33f9c87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8793","original_object":"UniProtKB:O75747"}
{"id":"6878be42-e2b9-451a-b7df-d0065414bb09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I60W9520VV","predicate":"biolink:affects","object":"NCBIGene:54583","sources":[{"id":"urn:uuid:5df81669-0035-4142-acc5-3879f768e652","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11831","original_object":"UniProtKB:Q9GZT9"}
{"id":"610df209-6d6f-4419-9f18-d143eda23968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4869149","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:9019e326-2717-4920-97c3-0053d283c8cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11690","original_object":"UniProtKB:O60885"}
{"id":"8753ff4b-fedf-4b46-b4b3-c8c8ee436003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:851NLB57HQ","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:0fcad263-a1c8-4459-baa8-d9a892ed8b6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1225","original_object":"UniProtKB:P31645"}
{"id":"74b5bd4f-b70c-489b-8ad9-bf8a18ea868a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47499","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:ef3eb4e5-a110-4b41-b5d0-cf3fd1d7d3df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:357","original_object":"UniProtKB:P48545"}
{"id":"21b71b43-7cdd-4009-94a7-e997f53a7033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34486","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:3e04bb52-1bc9-4b62-8bfe-3d0c034c2960","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2679","original_object":"UniProtKB:Q07869"}
{"id":"5d091088-4ed4-43f1-990e-ea1da8cee4ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7577","predicate":"biolink:affects","object":"NCBIGene:12289","sources":[{"id":"urn:uuid:6166d953-ed24-4fbd-b03a-1ad89647544b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2524","original_object":"UniProtKB:Q99246"}
{"id":"4e36ba6a-ec45-4206-a6fa-0c56e8ff4ccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:a9c51904-14fb-4e5c-9c5a-bb9b217c6f95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P30936"}
{"id":"a707623b-115b-4da4-b308-cb4740ca3318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:3111d3fd-6520-4367-a207-49e68de848d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P31388"}
{"id":"c7af054e-2153-4772-a721-5a6139078fcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22991950","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:848faf8f-7c75-4c12-ad04-71d118f36d7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:326","original_object":"UniProtKB:P08483"}
{"id":"d2a822db-de3a-4514-a19f-35946490e607","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M7X64VTLI","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:1dcb82c0-16db-4cca-8839-4043ebedefe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13204","original_object":"UniProtKB:Q86V86"}
{"id":"53abe508-9b23-4c26-816b-30bd15d29013","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:b14c82e3-b24a-4bf3-ad41-8468be41c2b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:Q8TD43"}
{"id":"bf95c711-771c-49d6-9a70-f6cf12197ac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:91db7f32-5d10-47e7-9f58-9d21ca284ad6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P35368"}
{"id":"d6f63cde-007d-45c2-b92c-8b5ab5fb137d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195521","predicate":"biolink:affects","object":"NCBIGene:8798","sources":[{"id":"urn:uuid:02ec8db8-a573-4320-9fe2-71f608181a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8167","original_object":"UniProtKB:Q9NR20"}
{"id":"81d88203-9e97-4d2e-aca8-5b98f61dd8b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231208","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:36594c47-a526-4c3e-8660-50b538915be7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1934","original_object":"UniProtKB:P43252"}
{"id":"e85469c6-38cc-403f-95e2-f9bb522ac179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:314eb108-56ec-41cc-b6fc-9cad1cb81a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:P47211"}
{"id":"18df8ca5-244f-4ae0-b006-878f17d8b939","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321160","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:cd2e795a-00ff-4d97-b301-2d80ca8f4b17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10157","original_object":"UniProtKB:O60674"}
{"id":"a0069a64-b3bd-471a-85a5-d8eb6aff0746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11556309","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:a5e95e7b-58e8-4df7-bc08-0fa8e40274d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:793","original_object":"UniProtKB:P51677"}
{"id":"fdbb538d-c03f-4ba9-86eb-09d16156fe78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54582152","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:884bb8a0-a5fc-49f7-be3c-94b27739e0c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5740","original_object":"UniProtKB:Q8TDV5"}
{"id":"dad9b85d-d00c-4e50-8cdc-718bc182d8bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78331","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:9ebd1883-a853-4b03-b337-7e18fba8f8de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9404","original_object":"UniProtKB:P06239"}
{"id":"27adbbdd-ca3f-49e8-a924-8d03dc8fb3a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140524","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:6b8cd03e-aaf0-4499-b40b-420c47645dfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4205","original_object":"UniProtKB:Q9EPK8"}
{"id":"5aabd6ea-767b-444e-8d81-86cea65c853b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0BQ383G656","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:e03a3110-1fba-479a-bc24-b290bc8cb75f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11860","original_object":"UniProtKB:Q8TDD5"}
{"id":"22121933-66a3-444d-8a32-96f23dd56b8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92180","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f92965ef-704b-4c18-8645-8eafbcf6e43f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5620","original_object":"UniProtKB:P30542"}
{"id":"c31d9cb2-839c-479a-bef5-0bcb60672682","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9118","predicate":"biolink:affects","object":"NCBIGene:2692","sources":[{"id":"urn:uuid:3cab0091-9024-43a0-8eaf-af61a05b4692","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6998","original_object":"UniProtKB:Q02643"}
{"id":"e80242bc-3d68-40be-ab39-4b18da8bd9f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W6F4FRQ5QC","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:039f71d0-a8af-4dc1-9e08-5405828caaa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11284","original_object":"UniProtKB:O60341"}
{"id":"e1bf798c-3d90-4d0f-8ec5-2b5241b1af6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:3745","sources":[{"id":"urn:uuid:54e92b25-27ce-41e5-be8a-0834a9446477","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1052","original_object":"UniProtKB:Q14721"}
{"id":"1cff553c-01f3-4c4a-b554-e1bb49c8c08e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2J3H5C81A5","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:30f7752e-dbe3-40f0-9c28-b2a5b2bf8168","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11135","original_object":"UniProtKB:Q07869"}
{"id":"15ec7522-7abd-4fd8-bba0-72b8926b3b22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:782b38e7-b66d-4331-b7aa-4865b0758d4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P41595"}
{"id":"05eee413-599a-4143-99ed-5307a1882a07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1529","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:050f8407-4106-4d54-8b87-4cb702d57c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1529","original_object":"UniProtKB:Q63634"}
{"id":"be6ce393-8ade-429b-a8c5-45e896f86c54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993645","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:e0d76a11-9107-4512-bf2a-403db3866802","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12493","original_object":"UniProtKB:P55085"}
{"id":"58c588b3-a1df-4ac8-a4a6-6d9a25b2da95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91541","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:090173d9-7622-4e45-935d-3a4584bc5ebb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:330","original_object":"UniProtKB:P20309"}
{"id":"809f0b0c-2258-4994-9400-8907446154bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38322","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:74852fa4-0d9b-42a8-876b-486712388a9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:303","original_object":"UniProtKB:P08172"}
{"id":"bc5ed9ac-bf2f-472e-8bd0-2fffd56e967f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2904","predicate":"biolink:affects","object":"NCBIGene:24925","sources":[{"id":"urn:uuid:d510cedc-4e47-4950-b040-69d403291ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:548","original_object":"UniProtKB:P18090"}
{"id":"defac88e-7ecb-4174-94f6-1d9db889e8db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:972a9fdb-3eac-42d3-9de5-e6442d7bb0f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P20309"}
{"id":"c3f6dfbd-0dbb-4447-a4a3-3f7f6ea8f1b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8979","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:985a2d61-46a4-4391-940b-ac6dc234c819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:192","original_object":"UniProtKB:P28335"}
{"id":"d4c0c381-4593-4b12-b3ba-cf9b07476aee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31835","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:745ff89a-dec1-4d30-aee6-9592d3963502","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6273","original_object":"UniProtKB:Q8BLA8"}
{"id":"1098f216-c686-4f85-afab-e85b8affac50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2545","predicate":"biolink:affects","object":"NCBIGene:24520","sources":[{"id":"urn:uuid:c951d0e7-6f4d-4aa0-8da9-7ccdc4bab2c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2545","original_object":"UniProtKB:P10499"}
{"id":"54d95d35-c321-4a6b-aa69-ba324eec76cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145998143","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:fc2a7291-d614-431e-8c94-92379d955cb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11054","original_object":"UniProtKB:Q6IQ20"}
{"id":"144f72f3-2b54-46a6-bf5b-e20f851ff2ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:96711H97SD","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:e5aaedeb-e1c2-4e97-91e0-80b0cff271fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2165","original_object":"UniProtKB:Q9UKP6"}
{"id":"93c0bcaa-b2e6-4414-8420-cb943a572f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:b54a0f2f-51f9-4325-92a1-d97560dc230b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P30874"}
{"id":"650ab717-a69a-4512-9398-cddb9f4d5bb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0K5743G68X","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:2500ef40-abe0-4834-9291-ce6bb91d4b83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9302","original_object":"UniProtKB:O43613"}
{"id":"f669f94e-fa0a-41f5-b34e-07219910e788","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7506","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:ac7544fb-7386-4e17-a7f1-ba32f1adafc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7506","original_object":"UniProtKB:Q92793"}
{"id":"dd6f2560-3638-485f-a799-756a193659d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46937420","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:b051e167-238b-4f61-b80a-8115c78e5087","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6260","original_object":"UniProtKB:O88704"}
{"id":"9d3f185e-d0b3-4160-aa9a-8a8963809be6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135983","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:2d6b4d2a-4cf4-4d3e-b438-cff119ef0e72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4448","original_object":"UniProtKB:P70555"}
{"id":"90f023b2-310e-433e-947e-f050505a6926","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:1612","sources":[{"id":"urn:uuid:bf559421-17bd-40e9-b427-2e3effd10969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P53355"}
{"id":"97329582-821e-493f-a725-d8187b38a5b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47780","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:109980fa-f83b-4102-93d7-c914bda0d477","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2398","original_object":"UniProtKB:P23975"}
{"id":"ef687e27-16b2-430f-932a-252581c3414e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:56b5c88d-adac-4964-b0e0-327d97bc0dfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P00915"}
{"id":"be025ee0-dbc2-4632-9af1-078aeaa864c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13302","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:bce796f9-56f7-42cf-ac3e-cb338a2b1cf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13302","original_object":"UniProtKB:Q06418"}
{"id":"7e921db0-1b11-4fb5-b816-58ca886fb6a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195521","predicate":"biolink:affects","object":"NCBIGene:8445","sources":[{"id":"urn:uuid:c22c49d0-b4bf-4928-95bd-d1e3ac12e3e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8167","original_object":"UniProtKB:Q92630"}
{"id":"4bab66a2-eca2-416e-933d-d579c0888b16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Z28M5SX0X","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:21e8186c-af56-4190-ab7a-7c0588a9d5d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10627","original_object":"UniProtKB:P48736"}
{"id":"671005da-0f46-403c-8254-471d238d715e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:7a5e81c6-1445-4c70-9b63-c58ed1fca265","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:O60885"}
{"id":"37a7c44b-f8ff-4642-a853-f2f9b3c71062","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679553","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:f7605005-1a14-4f84-a4d8-1153dfab2b22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11954","original_object":"UniProtKB:P13631"}
{"id":"e9f11c47-5cff-49a6-bb4b-4ee207419c23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9842556","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:fbac42d7-c695-425d-9aa3-84fdd2f1f0c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6557","original_object":"UniProtKB:Q08499"}
{"id":"044d3bc2-cc96-4142-93b3-76af05c31e1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755233","predicate":"biolink:affects","object":"NCBIGene:81681","sources":[{"id":"urn:uuid:e0bac7e8-f24d-4269-a050-855e63dbc4a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6721","original_object":"UniProtKB:P48450"}
{"id":"0a404e94-a4c6-4d32-be9d-e552db0561a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:819b2834-9264-4c84-b2ad-07362e121c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P47898"}
{"id":"f1903961-9af8-461c-bc7b-ff36c1f9140d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:5f58f592-7e87-41a9-829f-2224e3358d9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P34969"}
{"id":"e7a6f6f9-46b2-4c33-a060-667a7156f9c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817422","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:ecb3df30-1769-4210-8fac-896418e77955","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1549","original_object":"UniProtKB:P49146"}
{"id":"f6821061-e566-4ec9-8e1a-5c60ec4707db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817423","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:a5d69fac-5dea-4c0a-b138-ef779de4da5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1550","original_object":"UniProtKB:Q63447"}
{"id":"ac7437c4-db81-4fa4-84fa-1846d14834f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95093","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:5c472cb7-3f0e-4929-bb55-2d0f674b9b43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8974","original_object":"UniProtKB:P42345"}
{"id":"28d09008-5c2d-4f24-ae06-c30585e952d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195557","predicate":"biolink:affects","object":"NCBIGene:239","sources":[{"id":"urn:uuid:0276b231-8cb3-4e25-8925-883d37bd865c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8752","original_object":"UniProtKB:P18054"}
{"id":"a25a1350-c4fe-4ed0-8721-55b0719e2050","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3764681","predicate":"biolink:affects","object":"NCBIGene:3745","sources":[{"id":"urn:uuid:086b390f-4b64-43b1-82b0-7200c0532529","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2569","original_object":"UniProtKB:Q14721"}
{"id":"fbf19564-0643-498a-a145-6b288dae0c99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132203319","predicate":"biolink:affects","object":"NCBIGene:6240","sources":[{"id":"urn:uuid:4431b738-8bb5-448d-aa0e-e542909dd0ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12113","original_object":"UniProtKB:P23921"}
{"id":"7c6a6e3e-c4fa-479d-9a8b-d20722698f78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130961","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:6aba2c66-c299-4af7-8069-97da3f40e9c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2005","original_object":"UniProtKB:P35346"}
{"id":"a16baca9-76db-4488-8658-c433f38cb589","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80270","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:6035d37c-6bab-4989-a7b5-175a81fdc90f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1134","original_object":"UniProtKB:P43220"}
{"id":"9cc80907-8475-491a-be04-b5ffae82fd8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311423","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:8d579a06-5fe5-4e5e-aa83-4971ec60b638","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:257","original_object":"UniProtKB:P34969"}
{"id":"4583fc53-453a-44df-9ee4-5c51cdac7a98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13395","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:54856205-5026-4d7e-9191-445a60cf0662","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13395","original_object":"UniProtKB:P41143"}
{"id":"6e54dc45-9f54-4755-bd9e-51cc816471b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:1f123b40-3d5d-4f6b-a968-daf2137f7908","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:P00519"}
{"id":"1453407a-5a8e-4480-8963-31f8124c109a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107736","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:683a1f89-8985-4153-8c92-8a85463a8ca8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:241","original_object":"UniProtKB:P97288"}
{"id":"ca58f6cc-51a0-442f-84f8-113cc04abba9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4126","predicate":"biolink:affects","object":"NCBIGene:358","sources":[{"id":"urn:uuid:db920925-4015-4863-b171-078426e243fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4126","original_object":"UniProtKB:P29972"}
{"id":"18496ca6-5709-4440-9fb1-fc844bc52a62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118086034","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:5242a97b-2243-4d6f-bfee-a9498ee74582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11664","original_object":"UniProtKB:P33981"}
{"id":"ceff4193-ed58-4c0e-8854-58742fbb019b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163410393","predicate":"biolink:affects","object":"NCBIGene:4323","sources":[{"id":"urn:uuid:ea8057e4-c282-4063-96c4-6049e0f0d4fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12057","original_object":"UniProtKB:P50281"}
{"id":"fd0cebda-8b08-4b8c-bdf2-8ff1c75cf884","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9930376","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:21369da3-43a3-4c44-bae7-9002003606b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13151","original_object":"UniProtKB:P35368"}
{"id":"0ea25305-7a84-4e67-abd1-a1a949334201","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1800","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:93bc9038-89fe-4df6-91ca-fdcaa1b60bf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1800","original_object":"UniProtKB:P49190"}
{"id":"39bb3980-2fa4-45a7-94a4-792fba800350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10344307","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:32bebe78-9ade-4452-b729-bdf7a5716719","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8629","original_object":"UniProtKB:P22894"}
{"id":"80fa88ae-6368-47f3-bbdd-6f8918601052","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2064","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:bf5e521a-a8ac-4c17-a25b-94339b847500","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2064","original_object":"UniProtKB:P35346"}
{"id":"f78e27a7-27f5-4680-a205-bb66a684184c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7009","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:e4e819a5-ebb0-45dd-97d2-63d38bb41ded","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12574","original_object":"UniProtKB:P18089"}
{"id":"9d9beed7-bf45-47d6-a10c-a2ff8ac20994","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:9374b358-2f3d-4458-b344-4af0a82ca213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1052","original_object":"UniProtKB:Q7Z2W7"}
{"id":"265c64c2-108e-47cb-aef0-a159add429a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2026","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:165a3c95-25ef-4fde-b89a-7b17b295cfc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2026","original_object":"UniProtKB:P32745"}
{"id":"90719405-fd85-45c7-97cc-f1e8e7e0330f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18346","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:bb5489c5-558f-40a6-9bf2-b95ce20c0bd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6412","original_object":"UniProtKB:Q9NYV8"}
{"id":"9990cce0-4ebd-435d-82f1-89e4aed28265","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6442223","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:33c6d8f9-63e6-44f1-b902-2e44d38485d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2814","original_object":"UniProtKB:P37231"}
{"id":"49f40f28-39e2-4cb9-8a7f-dbad7c288e92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4I4P4I2E8P","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:1463a6e4-2782-4e16-bab1-b94d8e746114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10349","original_object":"UniProtKB:P25103"}
{"id":"ee424264-28b4-4340-a19f-37de63c22e3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56680468","predicate":"biolink:affects","object":"NCBIGene:5802","sources":[{"id":"urn:uuid:1d6675d4-be84-4dff-a8e7-46135fa2e45a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8850","original_object":"UniProtKB:Q13332"}
{"id":"99247612-0ba9-487d-956b-fd25bd8e8de4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91810","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:81912eca-d791-43c9-be48-cdc0b519f4ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:245","original_object":"UniProtKB:Q62758"}
{"id":"8095ac84-5d10-44c2-bd06-1907f06739ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16236","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:ce926147-9b10-4861-b661-dcff90a206c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2299","original_object":"UniProtKB:P48545"}
{"id":"a997b1fa-fd6e-4891-9677-c10cc92ccaa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78210300","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:69513420-6d54-4621-a2fd-2816c773324b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9443","original_object":"UniProtKB:Q96P65"}
{"id":"49bf7cc7-34db-44d0-a98e-b2642d14b19f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:13389","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:2e295a3b-8ee7-4168-9919-76929d975d09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2451","original_object":"UniProtKB:O94759"}
{"id":"b995fb79-edb9-4f7f-b5d6-5a27b62d9d71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZD6AG3N96D","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:c9fe83fd-b057-4c91-8efd-a5e441b97750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:176","original_object":"UniProtKB:P41595"}
{"id":"7f1aa1bf-018b-4984-a8a6-6c1e2fe30178","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8KC1PQ31A","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:619a28e5-dc42-44f8-92ff-cfe0ca2110b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1397","original_object":"UniProtKB:P31422"}
{"id":"0d090837-1982-42b5-9b73-27fe68a6111b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8336","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:9cb4d806-c8a0-4a82-8a49-dda86af41399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8336","original_object":"UniProtKB:Q9NSD7"}
{"id":"63df33a7-819a-41a0-827f-a13f49489859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2212","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:1cf79057-2866-4d08-94f3-46b7d8968d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2212","original_object":"UniProtKB:P30518"}
{"id":"1ebc62fd-518f-45c4-a619-d77ac9a1649d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27999","predicate":"biolink:affects","object":"NCBIGene:3767","sources":[{"id":"urn:uuid:a02a365b-c429-425a-a04f-3e8d19c1c31e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6848","original_object":"UniProtKB:Q14654"}
{"id":"bd7dc45e-ffea-45b0-8edb-36157370828c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91357","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:ba46da0d-7d04-4e4d-a359-35c57656e71b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8007","original_object":"UniProtKB:P24941"}
{"id":"2fce9de8-b93d-4725-a2da-de415a25eb65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10512636","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:1de423a5-f36e-46a8-b7b1-cdd48a0ed2f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10433","original_object":"UniProtKB:P00915"}
{"id":"6c03ebea-7234-4259-aea6-6213adbfc0e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:834YJF89WO","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:55358b9f-8c5c-4aef-bcec-1a8ae59f71b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9558","original_object":"UniProtKB:O75116"}
{"id":"0a68175d-beaa-44fd-9369-b72e82288df1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130345035","predicate":"biolink:affects","object":"NCBIGene:4015","sources":[{"id":"urn:uuid:44d30d72-b3b9-4ff2-8627-a35f273a4d9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10485","original_object":"UniProtKB:P28300"}
{"id":"7ea85a76-8e90-4f30-9481-9041c870bd52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755099","predicate":"biolink:affects","object":"NCBIGene:6506","sources":[{"id":"urn:uuid:58752a24-c73d-4cb9-be08-04254b285125","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4571","original_object":"UniProtKB:P43004"}
{"id":"a00f2be1-4876-4a61-9c1f-a95fb251e05b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2066","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:53e1540e-de57-4841-9700-a97fe5aa2dc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2066","original_object":"UniProtKB:P32745"}
{"id":"6cf9120f-a98c-4957-9f22-ac8d276c5441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16755","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:0c42476a-2606-4d6a-a15b-f9207fdaffc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:608","original_object":"UniProtKB:P21462"}
{"id":"2a4643b0-2084-4b6a-9c3f-ba97292f64eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135694","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:74430b40-cb90-4da6-9578-c73293f388e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2197","original_object":"UniProtKB:P30560"}
{"id":"668e38aa-388d-4260-855c-0f404d02bcf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9165","predicate":"biolink:affects","object":"NCBIGene:2986","sources":[{"id":"urn:uuid:81ea83f5-5eba-48e8-89b6-4b36865489f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9165","original_object":"UniProtKB:P51841"}
{"id":"5dc98732-b64c-4298-bcda-bbfba0c583c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:74125","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:d37328dc-634d-4feb-bd85-86d3640b9f56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:586","original_object":"UniProtKB:P30556"}
{"id":"d9e66479-724a-4186-8a8e-894483309010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9W5677JKDA","predicate":"biolink:affects","object":"NCBIGene:2057","sources":[{"id":"urn:uuid:9838ea29-cbbb-496d-9274-fa447bb9b370","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9677","original_object":"UniProtKB:P19235"}
{"id":"e4fbef63-a9af-4eea-82a9-48278af31f0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3547","predicate":"biolink:affects","object":"NCBIGene:8323","sources":[{"id":"urn:uuid:2417beef-faaa-4350-9d02-59bd61ffa842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3547","original_object":"UniProtKB:O60353"}
{"id":"1a1895ba-ca03-49e7-91f2-6458e74068c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817495","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:d12c044f-cbcb-4def-aded-b75d12fb55c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6266","original_object":"UniProtKB:O88536"}
{"id":"e2fa32c3-e588-453d-8d65-1b2d80ec36cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:4bd2eafb-10eb-4f4d-9def-93c03249b997","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:P51451"}
{"id":"6d494386-6711-4ab9-9110-9c58869c099c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92484","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:cbd12062-e7e6-4297-87dd-f83ecaee7124","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9967","original_object":"UniProtKB:Q9Y2T6"}
{"id":"d81a4451-31c2-4fa4-a655-788fe7a2ec3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118665873","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:7067b4af-fdd5-4560-aeca-053b47b90e28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13919","original_object":"UniProtKB:P36888"}
{"id":"37ae2978-0c02-46c7-a4ff-e4270c13139b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92070","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:910453a9-c6a6-430f-b90f-d24b84917740","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:94","original_object":"UniProtKB:P14416"}
{"id":"c957b58a-f74b-4de2-9646-b58b8368088c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9967471","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:112af803-77f1-426d-9e66-08902fa38345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6450","original_object":"UniProtKB:P41594"}
{"id":"c01d689f-e315-4d03-92c0-72f22b9bebb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:5752a7b0-2e7f-45c6-8bc7-7afa374e2da1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P28566"}
{"id":"1c51756b-a118-492f-acac-7a6f1e0c8a4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11417","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:eae93202-a53e-49b6-a06b-ce4c89e96ac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11417","original_object":"UniProtKB:O60755"}
{"id":"8c87d982-6a6f-4f3c-a698-835b83ff75a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156855755","predicate":"biolink:affects","object":"NCBIGene:7004","sources":[{"id":"urn:uuid:3280fbd7-0def-4a7f-b0ad-f373fcbd5e0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13367","original_object":"UniProtKB:Q15561"}
{"id":"129e5801-91ea-461b-9bd1-be23f2f7e554","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9846078","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:95ea0cd0-f0ee-4049-82a3-9c8b1dcd164e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5772","original_object":"UniProtKB:P29371"}
{"id":"40126009-fd8a-4f4a-921e-eaa8fcd8f585","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z7YP8B158Q","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:bc26b28f-5b89-4e15-86f4-c2960ec7fc5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:531","original_object":"UniProtKB:P08588"}
{"id":"ada899ab-f5cd-4627-bd5b-a8dcacd5aa64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63631","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:ef84a379-eccf-431f-911f-5608e3b198fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6849","original_object":"UniProtKB:O43570"}
{"id":"f981d1ef-d6e7-4a3d-a18f-38f0fd130872","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W71J4X250V","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:3670ef71-a487-42c6-91e5-fccd95710990","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8382","original_object":"UniProtKB:P48736"}
{"id":"7d21d551-265b-41ba-89bf-f4cb349ea909","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94166","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:390ebffd-36b2-4dee-8aa4-f30342ff354d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7374","original_object":"UniProtKB:Q9UBN7"}
{"id":"4ad1589f-631a-4fe9-b49f-f97fcb87a745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15659415","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:fae5606b-af0f-411f-9a46-a92bd4c66205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4101","original_object":"UniProtKB:Q9Y210"}
{"id":"c8a2f2a8-52cf-4b68-be0b-261f8a696162","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156297","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:2d9ebb73-e311-4e3f-8543-810dfd36f6b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5571","original_object":"UniProtKB:P08588"}
{"id":"bb8b8f16-9ed7-45c9-8a7c-eaa4c202a6a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:50393ddb-88cc-40f5-9f3b-086bc73719e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P41595"}
{"id":"4f0f636a-ae9e-4607-b4f9-79d7834a6290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277839","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:2e260250-5578-44d3-9ea4-79edcd646470","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7779","original_object":"UniProtKB:P49286"}
{"id":"9f5f2327-906a-4312-8871-cc4ea148fbef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JYO8VTR11","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:2e26d9b5-a65d-49a1-a83b-43a8996598bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10158","original_object":"UniProtKB:P28845"}
{"id":"dcc3a0e7-1f32-4239-a230-8a75bab0a154","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827362","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:95612d0f-4dda-4958-a87f-9ec6208ce969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8492","original_object":"UniProtKB:O15554"}
{"id":"a12c944d-43ab-4c2a-9e19-632fdc0a5e25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34541","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:f51f69f8-d80b-45b2-a84f-ac2e52afd907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4138","original_object":"UniProtKB:P42261"}
{"id":"f509f847-f225-4e44-92bf-a3ba256b5c04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73349109","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:163667a8-6b77-44a6-8f79-453ad2b31bc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1706","original_object":"UniProtKB:O43613"}
{"id":"b0f67b1a-cea4-41ef-b177-c5c5667ad4f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:URX2UMQ8XV","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:1c89b69a-4b9d-47d2-8cf7-e79802d2c49b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9763","original_object":"UniProtKB:Q05397"}
{"id":"89f70930-a437-4a30-a200-d1e53107b619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:131890","sources":[{"id":"urn:uuid:14b8af8b-d9d8-4094-8d6e-fd7aa91a61b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:Q8WTQ7"}
{"id":"e8194b64-a54e-454f-bb95-30457160461f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121921","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:58a9c440-4b99-4992-b12e-f0ac24660128","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4200","original_object":"UniProtKB:O94759"}
{"id":"bba970e4-c0f4-4e44-a10a-6aecfcbe1968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167600","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:ae5641f6-c40c-495f-9d7f-831a2c3eab38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9619","original_object":"UniProtKB:P52333"}
{"id":"eb17915f-3834-4c9d-abce-7b5a9f3fe5de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"UniProtKB:A2ARP9","sources":[{"id":"urn:uuid:2d649cf3-d3b5-4a6f-9f91-b271df7a1e3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:A2ARP9"}
{"id":"4a7ef96d-98db-4d27-a107-78e7fa2cccf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72203102","predicate":"biolink:affects","object":"NCBIGene:699","sources":[{"id":"urn:uuid:44371106-ead9-492e-826b-503545bca4df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8112","original_object":"UniProtKB:O43683"}
{"id":"ec46b338-39cf-4bd9-a59b-73f17a3e4722","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:01ca995a-98e8-4ee9-add4-5414b537618b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P28335"}
{"id":"b57ce8f8-625f-45a5-9dec-e0f3c6a72741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118308507","predicate":"biolink:affects","object":"NCBIGene:2830","sources":[{"id":"urn:uuid:c75f424b-90d2-48aa-918d-2abfaf96b04b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12665","original_object":"UniProtKB:P46095"}
{"id":"7d6ee568-7f6d-4d1a-9e86-9ec9b1471f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10743500","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:b132b3d8-13ab-42e1-b552-7e7d737e8f90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3245","original_object":"UniProtKB:P50406"}
{"id":"73339c27-da1d-45e6-b78b-71cd56e0bdaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92950","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:d2d61286-7d51-415f-980d-bbff1b710f6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:515","original_object":"UniProtKB:P35368"}
{"id":"4f08d328-f84b-4a48-a076-01d484b84a33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132992142","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:687b90d8-58b2-4943-ba14-4e85e7d64aeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9929","original_object":"UniProtKB:P00533"}
{"id":"c765ede1-d618-4346-a2ef-bf3c010f3b89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:727c48a2-af47-47fe-ac1a-dcffc8dc1de2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q5XXA6"}
{"id":"0cb61103-9bde-45ce-8acd-c778d3b83231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91936970","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:48dd389b-4d30-4127-bc6c-1c21b0d32c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9989","original_object":"UniProtKB:P53779"}
{"id":"bfd91528-acef-4ff3-b9e2-800f23b4b117","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:d75f7690-9d8f-4d5a-b9d2-4f404758f41d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P21817"}
{"id":"6983cb01-55cc-4556-b5e3-5dd2d709312f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13441","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:7ba2d63e-efe4-4640-8889-892f4d76ae57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13441","original_object":"UniProtKB:P30988"}
{"id":"1abcacbb-41dc-406d-bce3-caac2335c4cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3081308","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:565f6a5a-8ff0-42f5-aceb-627f485e3d88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:657","original_object":"UniProtKB:P46663"}
{"id":"7d844952-5ad9-477f-a7a4-333d46df7fec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:b0f72162-6786-4711-98bc-5bd5897ef2ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:O00329"}
{"id":"4d34d12e-1e06-43f5-ae24-e331b3564eb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C0WUS7XXE9","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:b3e7c230-e94e-4b7f-af1b-96442ae10c76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12010","original_object":"UniProtKB:P36888"}
{"id":"1068cf6a-a426-4594-bace-dcfb0401fd6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107660","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:92e117d8-2df2-4d16-b6a1-d78aabde1147","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2361","original_object":"UniProtKB:Q12879"}
{"id":"f80f40e9-e7d5-491c-86f1-e57217f21050","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8354","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:93803a6d-e9db-4762-9f74-2f111763c09a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7597","original_object":"UniProtKB:P22303"}
{"id":"21f55e37-d779-4b0d-8a20-f943b7449be7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155412853","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:75687e0d-9b96-44b1-aa85-b4f52a840001","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13337","original_object":"UniProtKB:Q92633"}
{"id":"c1ecf568-7281-43f6-bbac-f6cfaee004b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:2d7b45be-0ef9-4dcb-8ca4-ea1f127fe482","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P18825"}
{"id":"2907bae7-f2f2-4b05-96ed-9db8d512ffc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:2041","sources":[{"id":"urn:uuid:d42d41d0-2380-4adf-a033-7a8355fb0285","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P21709"}
{"id":"38184aab-7f7e-4671-9459-1491c6791723","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:67f06e28-7497-43ca-b2a2-3fa449bc2c52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P46098"}
{"id":"2f91cb93-77a0-4058-88f8-a78c3cefc8db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656733","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:88afda0a-fb20-4afc-a482-d981ace10114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2320","original_object":"UniProtKB:Q92952"}
{"id":"7cf95a58-038b-4430-a5a1-4cb5fc93e3b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9794656","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:57df3932-6c17-4a69-b128-412c4e003a44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:171","original_object":"UniProtKB:P41595"}
{"id":"581a2684-925e-4578-8c94-9d0488aa32d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132082","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:4ddd7ac7-f5ac-43dc-8e55-a81323b8415c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7007","original_object":"UniProtKB:Q92769"}
{"id":"03061073-acb8-4b95-bc1d-da4e82ca0dc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LH1ZTY91OR","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:0a12dd4a-395f-413c-930b-c610e07f0f2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11781","original_object":"UniProtKB:P10415"}
{"id":"efae5a0a-a8ba-43ef-91ef-d4d1717dc1e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49575","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:9ee7363f-a137-4dbb-b789-4ebbf5918403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3364","original_object":"UniProtKB:P14867"}
{"id":"d1384bc2-5077-4cc3-b882-4e8165733e70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93525","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:c8e6ee84-7b14-41f8-9e51-85687ca5f793","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:781","original_object":"UniProtKB:P41597"}
{"id":"d2777e1e-2822-4b7b-a6a3-e40a26f1f20d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76979","predicate":"biolink:affects","object":"NCBIGene:22064","sources":[{"id":"urn:uuid:356089ad-9fd4-42b0-9eb7-cd89425ca400","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2435","original_object":"UniProtKB:Q9R244"}
{"id":"eda72f57-9476-4e0f-83d9-820c6fe2973e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155771774","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:2288d927-283b-4dc0-86be-98c07e75cc8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12733","original_object":"UniProtKB:P35372"}
{"id":"2ddd56fa-b552-46aa-9162-563241ef0d38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5573","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:1edd5f51-5b92-4997-b81a-b77301b92956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5573","original_object":"UniProtKB:Q03431"}
{"id":"9fe3cd33-4f21-4dd3-a4e4-82a0668af9cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91378","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:d78e30d1-0741-41d8-973d-80546a810b24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10095","original_object":"UniProtKB:P24941"}
{"id":"9e2e5847-a989-4bb6-b731-cb5c26bdd353","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8998","predicate":"biolink:affects","object":"UniProtKB:P01854","sources":[{"id":"urn:uuid:d6e1d9f2-9853-40d6-8731-ac14806e3255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8998","original_object":"UniProtKB:P01854"}
{"id":"f275e38e-fdd5-4d22-95e4-ca47c830ac02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93424","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:b43f84bc-841d-414c-a961-69ae011de44b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:403","original_object":"UniProtKB:P29275"}
{"id":"d42e4fdb-fd75-4c09-8b6c-8bd604973c66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10119","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:7a8c0148-95fd-458e-9dd7-5b88092dfd80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10119","original_object":"UniProtKB:Q15858"}
{"id":"c8a3ef8f-c2ed-480b-a33e-58a4a10d1abd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66580799","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:4f9b5c65-f5e6-4d6b-b1e4-bc306ca226d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12487","original_object":"UniProtKB:O00329"}
{"id":"a3193d84-7f69-4313-8039-55aaad68b8af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16586","predicate":"biolink:affects","object":"NCBIGene:5340","sources":[{"id":"urn:uuid:141f748f-14b7-4aad-86aa-348b9e6882a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6574","original_object":"UniProtKB:P00747"}
{"id":"135c2e0b-25ea-457c-a18e-86a37ee6479c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76285486","predicate":"biolink:affects","object":"NCBIGene:79813","sources":[{"id":"urn:uuid:a5832f99-adad-4282-811d-d4c45867f2dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8238","original_object":"UniProtKB:Q9H9B1"}
{"id":"43a7ba9a-a8d8-4c9d-99ed-e5c52af0d2c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9840090","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:9af70ba0-309a-4c06-a594-216ca330341d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:157","original_object":"UniProtKB:P41595"}
{"id":"64cf4309-2254-47fd-acd6-fb9458f34d3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54671203","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:02665772-35e8-4981-ac2c-7a9caa0fd007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6464","original_object":"UniProtKB:P22894"}
{"id":"33dc6ce0-315a-43bb-8c67-dfaeb06f27d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918513","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:f8656b51-a1ab-4841-97c1-4ce7bf43638f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12","original_object":"UniProtKB:P47898"}
{"id":"1f05a9af-5754-4667-9eac-1b5e123e1fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1X0H7WEC5D","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:baf73527-0f26-4dac-93cf-8e1fb8c9aeab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8896","original_object":"UniProtKB:P43140"}
{"id":"3c7cd8fc-cacd-4a67-9b2b-d6821d38be92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:7e494143-8ef6-4a1b-9e20-32c3226c8639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P30936"}
{"id":"6d8d03fb-6072-4b56-a6ca-c6f05e63a7e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030525","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:dba85a5c-4d90-4ee4-a2d7-aba139fdecce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10444","original_object":"UniProtKB:P30518"}
{"id":"3c61a533-22f5-4156-877a-594662a11d89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:a234d8c7-769b-405b-aab0-4b6f06bfb479","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P41595"}
{"id":"6aad0340-3918-4be0-9d46-9f10f7cb0e28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:00ad28fc-4ffc-4a4b-9f62-5a8034af05b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P31644"}
{"id":"8e42fd13-3077-4226-92a2-03e2f351d51e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"UniProtKB:P57059","sources":[{"id":"urn:uuid:bb5df482-87ee-4b79-8f53-2bea95a39def","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P57059"}
{"id":"3f81ebcd-74e7-4bba-be82-aea1df44f015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9854861","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:33fbbe0c-f254-46ff-8781-eaf91c7ddd9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3797","original_object":"UniProtKB:Q9GZQ6"}
{"id":"e2884f0c-e10d-416f-bba7-7de0c8e85739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10042467","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:3767c3cb-485e-4033-9575-87440f74455f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1203","original_object":"UniProtKB:P35367"}
{"id":"8819a3ce-d615-400d-95ee-a40279197ce6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871820","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:4f3b6d00-8879-4bb6-a518-c4eb946b6b32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8184","original_object":"UniProtKB:O75116"}
{"id":"23b2c8e5-8334-4441-9dfe-7b6c75c6a8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92539","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:0cfe30fe-9611-4f5e-a3bf-8175360a6e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9","original_object":"UniProtKB:P35368"}
{"id":"8998e96c-e829-49f9-898c-f1c9418ff076","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:65267","sources":[{"id":"urn:uuid:5194ae5b-6e45-4273-ac3d-ddf9612dcbff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:Q9BYP7"}
{"id":"39267c9a-81de-4b28-9de2-813525d80b22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11625520","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:2a432bd4-b3cb-42aa-a64f-ceef3f344abc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4059","original_object":"UniProtKB:P41594"}
{"id":"8e43bfdc-9b55-4d9c-849b-e607298d79a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:8038","sources":[{"id":"urn:uuid:00e54b3a-4aa6-48b3-a82b-62243201b172","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:O43184"}
{"id":"d56af26e-dac3-4038-8186-f1be0fe837d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:947ce31b-aa59-4287-bcd2-57284406f95d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P35372"}
{"id":"a7962159-0785-442e-a667-b5dd38c631c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OE1QTY7C25","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:d4f04b28-ae52-4b21-ae44-b3525b183ad1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10631","original_object":"UniProtKB:P29597"}
{"id":"294c0183-6dc7-48a9-a108-360b703ef354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2191","predicate":"biolink:affects","object":"UniProtKB:P48974","sources":[{"id":"urn:uuid:98d9ec1a-fe2f-4097-bae9-06e3d19a57a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2191","original_object":"UniProtKB:P48974"}
{"id":"4c17e7f0-d330-45ca-b623-12d55d4112ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XOU2D9049G","predicate":"biolink:affects","object":"NCBIGene:641","sources":[{"id":"urn:uuid:4c236bd3-ed65-4175-bf0d-a42fe1067393","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13024","original_object":"UniProtKB:P54132"}
{"id":"39b26a67-cc0a-4c79-8f8a-ecfa714e57fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:88141473-0196-4ea6-81d4-f586d61ac947","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:Q62053"}
{"id":"b108be3b-891f-4c73-af23-eba1b1b3550a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230495","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:a7a02f43-6794-4079-8ea9-1f603e65bc0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8954","original_object":"UniProtKB:O14744"}
{"id":"bca7e88b-fa0f-4a7c-86a1-faa1e6d817d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:311Y5GV21M","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:6cb6afa6-3e2d-4422-b410-67617f31ec14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10059","original_object":"UniProtKB:P04150"}
{"id":"59bf03cb-4afa-4ed7-85d3-3d674d22bf96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44572147","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:dbf3af2c-ecbe-4949-8c92-c5b8c2999525","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6667","original_object":"UniProtKB:P32239"}
{"id":"aec78c6b-6c93-4f7c-a52e-8ed7fca17fc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44415153","predicate":"biolink:affects","object":"NCBIGene:24247","sources":[{"id":"urn:uuid:bf20e6a6-9e38-42f3-bd9b-a56c733ac1a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:715","original_object":"UniProtKB:P48442"}
{"id":"d2615d63-a5f6-477c-b50a-502771be16dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:b929fcdb-dc08-46d4-bde1-f0a840c25ea8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P47898"}
{"id":"73bc12ba-91a7-4a0b-8f37-543d607ad6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167176","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:4b4af311-319b-47dd-8821-97d6908e969a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11078","original_object":"UniProtKB:P0DTC1"}
{"id":"1cd061f1-f478-4da8-b1ba-27702258632a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:116225","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:a58c0a1d-7e21-482f-9cc2-ff7b6d5430dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4792","original_object":"UniProtKB:Q01959"}
{"id":"889924a2-5e2f-4bc0-a2ed-3034472294a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71455345","predicate":"biolink:affects","object":"NCBIGene:9340","sources":[{"id":"urn:uuid:f9133ec3-fb99-4d9e-b540-7dcc8f7184ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1143","original_object":"UniProtKB:O95838"}
{"id":"37bd87e2-39da-45c8-94bf-2447805486b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:6506","sources":[{"id":"urn:uuid:2b6cb2e5-86b0-4628-ab61-280944b2db8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4317","original_object":"UniProtKB:P43004"}
{"id":"d07b4b98-a3e6-46dc-b0e5-d4dd614135a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154659439","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:8406c12b-6077-4d3e-8708-86eba24b05e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11310","original_object":"UniProtKB:P04150"}
{"id":"17b0d64b-ce50-4cce-9db9-32711e962731","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53308747","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:acdb1d94-5876-44f3-bd31-84ac1b652902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6487","original_object":"UniProtKB:O15552"}
{"id":"c4e2f26b-1059-499a-a354-2653494f0a44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71041983","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:5579990e-983b-4a7a-9b3e-b46cc64f87c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6706","original_object":"UniProtKB:Q14831"}
{"id":"90f42c64-ed8d-4a6c-b663-ba03f969ad96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:6bc480bf-e22e-41fa-b46f-a6c188b91b77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P43114"}
{"id":"326c1ee3-52cd-422a-9ac0-d4bf613d0c87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023868","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:0646ccb4-74f6-4182-bed6-bc83699753ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3193","original_object":"UniProtKB:O95749"}
{"id":"6d86725c-01fd-4f29-ba8c-d077e7f62231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11241135","predicate":"biolink:affects","object":"NCBIGene:1075","sources":[{"id":"urn:uuid:df8cd4fa-34c9-4510-ba62-bfb658fdd074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8622","original_object":"UniProtKB:P53634"}
{"id":"c7fc4fe6-1508-4c23-a1b3-eef176454a0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2037","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:04fc8225-cae7-4b91-a750-08ea2fbe5d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2037","original_object":"UniProtKB:P30874"}
{"id":"803587c4-23ab-4545-9b94-fef21d468993","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947054","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:194ab38c-c11d-4345-839a-94db1f10d1d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3119","original_object":"UniProtKB:P37268"}
{"id":"e7a4bb71-14b4-46cc-a4d6-9d1881193ecb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:74bd10c7-e557-42d5-a4e4-47fe3650809b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:Q9UHD2"}
{"id":"a52c6ece-9756-4320-af6b-5024d018f867","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54K37P50KH","predicate":"biolink:affects","object":"NCBIGene:25549","sources":[{"id":"urn:uuid:7db2c23b-90f5-4fd7-8967-e8520a00bbab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8694","original_object":"UniProtKB:Q01827"}
{"id":"5335e6f0-2205-4609-abf4-daf467ea387b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:30a20c6d-aa3d-4d2f-ada0-08e08221621c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P10980"}
{"id":"344875b1-29e4-4c13-bbc9-8438b5fe7da7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16000100","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:b60e8ba4-f309-44e1-a6e0-f4095ff0bcc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6421","original_object":"UniProtKB:P31424"}
{"id":"986fd6cd-6bfb-46d0-b501-cd1488484dc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611894","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:e7074932-b412-4660-81dd-baf069d8412a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9997","original_object":"UniProtKB:O00329"}
{"id":"cb185ab8-7538-4016-9b29-e6c1c32b3a84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9784","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:a711f562-88c8-4867-b021-1e7367380253","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9784","original_object":"UniProtKB:Q99788"}
{"id":"21ac0bc3-f8ff-47ea-9ff5-7334b4f56b5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:762516b3-c49c-4804-854c-b11638749731","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q16322"}
{"id":"4389cb96-1626-4d0e-979c-384878ad4b4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:85eaeef5-d554-4b1b-8065-4fe2fe51ddbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30936"}
{"id":"d8842c9a-c46e-45e1-ac64-e627fd57a581","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145927371","predicate":"biolink:affects","object":"NCBIGene:19225","sources":[{"id":"urn:uuid:bf700e24-a9d7-4fd9-8556-fd9cf5410c9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10701","original_object":"UniProtKB:Q05769"}
{"id":"f4c8dbb9-ad6e-4c72-9081-c1e762c6d110","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086114","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:7570f91d-4694-47f7-b7d8-1856c307ee0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1618","original_object":"UniProtKB:P41143"}
{"id":"b77e49f7-0ba2-406f-802c-eb9a4697da50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10339001","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:83847adf-154c-4eca-8a86-74819419bc03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3064","original_object":"UniProtKB:Q02769"}
{"id":"2bc01129-c397-43e4-af22-a4588eceafe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:312","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:037e2b5f-adb9-4fb2-98c1-5862c53a958c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:312","original_object":"UniProtKB:P11229"}
{"id":"70fd5896-d358-46b7-828a-e678a8debea4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58961","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:968e6132-f234-4f2f-9ff2-470d65e0d5ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3635","original_object":"UniProtKB:Q9H1C0"}
{"id":"8e282fb5-7b45-48d7-93c6-ced03c5077c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A5595LHJ2L","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:e4c78c0e-8490-492f-a14e-7d41c75c6bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12644","original_object":"UniProtKB:Q15858"}
{"id":"49e6d925-4ad0-4653-b188-777e7de26311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:206ef342-6b0d-445b-952c-13152db3dd20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P14416"}
{"id":"398f5166-e9a6-454a-88f9-10239d794dbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135324","predicate":"biolink:affects","object":"NCBIGene:10892","sources":[{"id":"urn:uuid:be8fe340-97b4-4b22-b690-ca4ee4a06ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9782","original_object":"UniProtKB:Q9UDY8"}
{"id":"0a2f0470-2ba3-4bc3-82cd-fdb7150faeef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:5bf02c3b-60b1-4359-b4fe-a571e7c77664","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:O60674"}
{"id":"7ba83e53-9e04-429b-a700-b2f56991e8a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BIB7HG2V9E","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:dc714e39-36e1-42bf-843a-23559f087748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6501","original_object":"UniProtKB:P12821"}
{"id":"5db271f9-2c0e-4c6a-995f-f896d7dc9254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231425","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:a24c8a69-b34a-49fc-bde6-936f1ab5f3e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2226","original_object":"UniProtKB:Q00788"}
{"id":"8756db62-8b81-4e5b-8bb7-7d78b9db6da6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:63068d0e-a39d-4041-9116-d43ba84e5837","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P41595"}
{"id":"175a822d-5248-407a-84e4-84e3aa32e7e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34848","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:e32588db-4034-47a1-8a31-94ca09523239","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3031","original_object":"UniProtKB:P51639"}
{"id":"fb544294-67db-4b68-bf80-e6b7f1ac8400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8F5X4B082E","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:210bf296-a58a-446d-85ad-1dc9902fefc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2238","original_object":"UniProtKB:P30518"}
{"id":"4ec092ec-994c-40db-a009-952e7a51ccfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131997886","predicate":"biolink:affects","object":"NCBIGene:8202","sources":[{"id":"urn:uuid:c16cbf44-1e85-45c0-bd72-a6d3f6a2c474","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13308","original_object":"UniProtKB:Q9Y6Q9"}
{"id":"bbc975ef-b720-4a66-a604-733ca178f38d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95073","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:cc82e5ed-7704-47fd-b061-00c299d4236e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7010","original_object":"UniProtKB:Q92769"}
{"id":"433bf35e-f60a-4409-babf-156210f03b64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358782","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:9676fd03-4672-40a1-81a6-edd51a4895de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11981","original_object":"UniProtKB:P0DTD8"}
{"id":"71c69cb1-18e2-45c5-aaa1-c87e78f0f7f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4293970","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:8f363c03-42a9-45dd-b7ee-c4fe953c9938","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10151","original_object":"UniProtKB:P42338"}
{"id":"ec0795d0-bfda-4817-bd81-7b0b490e4276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:2731cd3c-9f77-423e-a460-69b0d75b9194","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P10721"}
{"id":"5f9efa66-2cec-43e9-9851-8107fcb30960","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135123","predicate":"biolink:affects","object":"NCBIGene:24925","sources":[{"id":"urn:uuid:0ec091fa-b411-4ced-8261-8fb29fca8ed3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:550","original_object":"UniProtKB:P18090"}
{"id":"f76275d6-1c09-4b00-ac32-cfea5139ddc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64069","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:63d9a2c8-907e-43db-bbaa-4cc084e0fa49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:130","original_object":"UniProtKB:P41595"}
{"id":"bb233526-7afd-4938-ab1c-faaf4e3f2a79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:1a792cbf-f3b8-40ac-a91b-90f15f4f5aea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:P34972"}
{"id":"124675ea-acab-4b47-b7d2-ea73a3852bbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1288","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:76ff8367-bbb3-4d3b-91aa-c8dacf0a0aa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1288","original_object":"UniProtKB:Q969F8"}
{"id":"6d747001-26c5-4c91-bc16-6e90e5602290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135928471","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:1f8011e5-ef94-472b-a15c-71d367afd06a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8185","original_object":"UniProtKB:P24941"}
{"id":"bcd9faa0-86af-449d-bd22-c117aca2d248","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12229","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:fb08ec93-a401-427c-8cc2-4be84fd7155d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12229","original_object":"UniProtKB:P07766"}
{"id":"dc4bac15-5c62-4c20-ac6a-e000603f1ad1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6914","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:7587c54e-1170-4571-9f45-42eae0d94d17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6914","original_object":"UniProtKB:P30556"}
{"id":"a2835422-57f7-4b57-a293-8792ad90515b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44256277","predicate":"biolink:affects","object":"NCBIGene:2869","sources":[{"id":"urn:uuid:f583a918-db15-4522-8be8-958ff6dc0d90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8143","original_object":"UniProtKB:P34947"}
{"id":"b9662867-e9ee-42df-962d-822d15f8937d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10078572","predicate":"biolink:affects","object":"UniProtKB:P97687","sources":[{"id":"urn:uuid:348b56da-36cb-4372-adcd-38f4c0ff307e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9030","original_object":"UniProtKB:P97687"}
{"id":"c7b8a361-8e5e-439b-832a-d2420f39c4e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135613","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:420fc30a-d4ff-4257-8884-a27778996a8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5596","original_object":"UniProtKB:P30542"}
{"id":"9be1f8aa-2979-4820-82f3-f92fd34ef49f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121486665","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:f39bbd96-7ed9-47a5-9757-3a6bfe74e7c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9198","original_object":"UniProtKB:P49841"}
{"id":"b1b026d6-e588-4713-98b1-8c1dac8d185f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138377580","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:8ae3273b-8069-4337-9f4d-475cfd397372","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12530","original_object":"UniProtKB:Q9Y210"}
{"id":"7b0ed1c3-1ca4-4c0d-bd02-b32c0ce623b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71624791","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:06d07ed9-506f-48d5-946c-a99a34463d9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8164","original_object":"UniProtKB:P10721"}
{"id":"72bc4bbc-7aaf-451a-a79e-cf53c6c0c380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45783","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:987cf74e-1dfc-4fc1-badd-c19f01a4c68a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5687","original_object":"UniProtKB:Q16832"}
{"id":"f741526e-de45-4ef9-a96a-18a6acc2560f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90170031","predicate":"biolink:affects","object":"NCBIGene:43847","sources":[{"id":"urn:uuid:c37d2b3d-38c4-42e6-ba1d-3caea92ec26f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8483","original_object":"UniProtKB:Q9P0G3"}
{"id":"5d4d3971-182d-4ca4-8f72-a478f800e461","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64191","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:0f2ba249-c499-4192-8e55-6f50095e8ed2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:44","original_object":"UniProtKB:P08908"}
{"id":"d519de65-6a87-495a-9501-03faf1b008aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:682930","sources":[{"id":"urn:uuid:770ae3a2-1910-4418-ba1c-bd4ff665f16b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q02485"}
{"id":"8df84ffb-c7a4-43d7-9dc5-c459217485c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16755","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:84a9b620-cfb8-4b43-96e0-f03f5ddbb9bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:608","original_object":"UniProtKB:Q96RI1"}
{"id":"79ccf9a0-54b1-4951-98a3-23633517bcbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44298287","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:e2de53e3-75f9-449a-83dd-c91b78ed4e34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3013","original_object":"UniProtKB:P51639"}
{"id":"c8e6233f-f269-4ca3-8453-a4a36b3deb95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K7G81N94DT","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:20230fe8-e3ef-4a13-aaa1-daee739fdf25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2110","original_object":"UniProtKB:P25103"}
{"id":"2eefe010-123f-4046-8d47-672bb2d1097a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68575","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:090ac668-6710-47a4-91cb-7355b814b852","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7455","original_object":"UniProtKB:P07550"}
{"id":"74ffa418-51f2-46aa-a235-35b7b9a8a55f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34457","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:e5f56585-2e4a-432d-b923-9ce2114f81d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4270","original_object":"UniProtKB:Q5XXA6"}
{"id":"351b805f-f06b-4f6e-9c04-12c07310d323","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118893637","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:c55044a1-4762-4cb6-8bac-259269851a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13218","original_object":"UniProtKB:P07333"}
{"id":"01226cb9-b33c-4fb3-91ae-4d4572f2e8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46970","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:97da25f8-48ba-4485-b1ce-46a03a51ef7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2922","original_object":"UniProtKB:O95977"}
{"id":"8a1872c3-7a51-4330-ace3-3502da0640da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:3223785e-4f1e-41a7-b7ef-74b642d72de3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:P35498"}
{"id":"a1b1784f-b3d4-4b0e-84fe-e634445f5ece","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WFG29AB872","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:25d1149d-99bb-41bd-a1a6-9dfff7f72854","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9928","original_object":"UniProtKB:O00329"}
{"id":"ba96d8f4-d6af-421e-ba22-0433d8d11fc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZXM835LQ5E","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:70bb5413-a6bf-429d-91d3-fe5985c349e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7902","original_object":"UniProtKB:P31749"}
{"id":"129c0dbb-66c2-4438-90e8-61b4fa3b6ca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:3055","sources":[{"id":"urn:uuid:e95fcfd5-09a9-45a8-8ce7-97ac74bd26ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P08631"}
{"id":"8d64b8cb-5ae2-430a-a6fe-06556a743265","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL499968","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:88230b84-1ef1-4d9a-885b-c905953b677a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2317","original_object":"UniProtKB:Q9H2S1"}
{"id":"cfa8be00-ac38-494c-b230-2075f507507a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2047","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:a78e39cb-38ef-4c2e-a980-a2c50c59711d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2047","original_object":"UniProtKB:P30875"}
{"id":"6f3edc8f-1d16-4005-b2c6-92ba1c200c8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2WZP8A9VFN","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:931f4f6e-81de-4aae-a2ba-f6e98847b346","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11677","original_object":"UniProtKB:P08581"}
{"id":"d9bcf75d-93d3-4fe0-b780-da7497881a06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:6b3f8386-808e-4391-88ae-f3ca458e3111","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2416","original_object":"UniProtKB:P63142"}
{"id":"f95dd7dd-e55b-432f-ac0e-395295d6d979","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15JL80DG6H","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:81b4e701-dc59-48fc-9610-17fb902f36ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10658","original_object":"UniProtKB:P15056"}
{"id":"fa17222c-6c75-41a9-81e5-94cc321e2321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34076","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:6ed0e2b8-92cb-4151-b406-85c84ab2853b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2314","original_object":"UniProtKB:P70605"}
{"id":"34111725-ea36-4533-8976-6945623483e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:760","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:75102568-cea7-4d96-8813-9830313a65c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:760","original_object":"UniProtKB:P32246"}
{"id":"c8c62312-6847-44e2-a649-234a2083d5fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1868","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:ee8faec3-4352-4f3c-96e4-c978f28f8601","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1868","original_object":"UniProtKB:Q8NFJ6"}
{"id":"18401fad-9413-4fb1-8f7c-efc81da71cdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:07ODS257BP","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:c9e01dad-6f79-4020-825f-018020442b3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10416","original_object":"UniProtKB:P51681"}
{"id":"f5a2267b-cc23-4464-8487-dc7124ffa976","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:a642b514-a8ef-47c2-b95f-9ab5f1bd84bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q13224"}
{"id":"5156a0d4-c646-417c-872a-921f1f25b19e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156371488","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:af6aa9e8-89ad-43e8-a3ac-cf5a483aa55e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12389","original_object":"UniProtKB:Q16620"}
{"id":"552f930a-60e8-4f20-a8e7-38801e123111","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:0d7d9e0f-60ff-489d-9449-7b7841ba5086","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q9H1D0"}
{"id":"e89e96df-a5b1-41d8-94d6-883c2e26d923","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345320","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:d7a73d5d-4d3e-49c7-ab9d-31a8461f8606","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9882","original_object":"UniProtKB:P61073"}
{"id":"f25b16fe-caf0-4d07-af6e-fba170c7ea4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0BQ383G656","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:881d3f19-b287-455a-bdbe-1e3ba520bef2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11860","original_object":"UniProtKB:Q9GZU1"}
{"id":"2777ccc3-9eb9-44a7-abaf-34616165782e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:5205d3bd-506e-4469-a1ef-53a8183efdee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P43115"}
{"id":"8fc92e63-d788-4123-8c55-835f9322acec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164887498","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:3af55103-def3-4e2a-bfd5-bb4d320a60b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12987","original_object":"UniProtKB:P00533"}
{"id":"9bee002d-0be3-4dc7-ab75-daad51e60b70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140420","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:032713a0-da28-4abe-a51c-ef487bd53093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7408","original_object":"UniProtKB:P00742"}
{"id":"047b2421-b237-46e4-8de1-c80397fc0a2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230819","predicate":"biolink:affects","object":"NCBIGene:6512","sources":[{"id":"urn:uuid:a676fa55-c2c0-48be-b059-f40ce1467443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4631","original_object":"UniProtKB:O00341"}
{"id":"abbce886-4268-4a57-a7bb-81c5933db874","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10512636","predicate":"biolink:affects","object":"NCBIGene:768","sources":[{"id":"urn:uuid:fc711c6a-9546-491e-b133-9f2df3f4e7e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10433","original_object":"UniProtKB:Q16790"}
{"id":"bc011e73-ab50-4e12-9dbb-551705127830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72305","predicate":"biolink:affects","object":"NCBIGene:9340","sources":[{"id":"urn:uuid:0f1a955d-ec4d-433a-8095-2e5b01abf35b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7049","original_object":"UniProtKB:O95838"}
{"id":"479e4cda-e2fb-4163-9bc1-a1b80361156b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22359367","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:e05e1401-502f-41e7-a838-ac47aa43c354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4107","original_object":"UniProtKB:P28476"}
{"id":"8958f474-6666-443a-b9c4-490e282243ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184982","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:eb904a3a-e854-4217-909b-7e7dcd59c218","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1239","original_object":"UniProtKB:P58406"}
{"id":"a7ea4c57-191e-4093-974b-095f8ed6ac0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9584673","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:9804c22d-04c4-42dc-81dd-cab185af85f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4134","original_object":"UniProtKB:O75762"}
{"id":"ea234835-c1ca-4a0b-91f9-4aa42452d14b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231397","predicate":"biolink:affects","object":"NCBIGene:587","sources":[{"id":"urn:uuid:dcc50c28-0902-4fe1-bbb1-b6cf5b31323e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9085","original_object":"UniProtKB:O15382"}
{"id":"2dbdfa51-14a3-4310-b0d4-e8748e9c97c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9150","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:119ad9a5-112f-4f73-bb47-6d6c98888884","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2955","original_object":"UniProtKB:P04035"}
{"id":"5d6292b7-3c7e-4253-93e5-403bf04ffd46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93348","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:2b09557d-d541-4e28-b8a9-5f78d3a50344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:495","original_object":"UniProtKB:P35348"}
{"id":"937bff6c-a489-4212-8da1-c668f2616d27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:08P99TX229","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:b56d62e8-ca56-477d-be95-03c6a417ec9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10082","original_object":"UniProtKB:Q8TDV5"}
{"id":"519873c6-989f-4df7-a098-68c29e3d517a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23121947","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:c746f4d6-35f1-4b51-a5fa-fea845a42369","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7929","original_object":"UniProtKB:Q6W5P4"}
{"id":"5c799343-fec0-4510-98b2-62ab99cb0fdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:87c3866c-5e11-49c8-9666-fe0aeca871d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P29274"}
{"id":"80620a0a-2f7d-4f20-928f-046ec223efcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25016538","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:a2994f75-1a00-45e9-b1e8-8efbf9b08e12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5862","original_object":"UniProtKB:Q96RJ0"}
{"id":"79846d8d-9208-4536-98ad-65b906f0ba2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:917","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:24725112-d9fd-4362-9200-7323f50c4e78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:917","original_object":"UniProtKB:Q13324"}
{"id":"c0e7a1cd-8882-4a0f-bad4-5fbe65f6ae6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321153","predicate":"biolink:affects","object":"NCBIGene:9682","sources":[{"id":"urn:uuid:08ba85de-b0c6-4ac6-988a-a453af97f34b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10141","original_object":"UniProtKB:O75164"}
{"id":"fe1db541-6c82-4fb2-b791-554a697b3f57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71818573","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:8d3a467b-cc03-4f66-a235-735524286df6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12529","original_object":"UniProtKB:Q9Y210"}
{"id":"25206fea-4799-498e-8a81-81ed9b784520","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:8e892f19-7bee-4ec2-9634-72174cc9b9b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P30872"}
{"id":"e71a3dd1-75ab-4374-8521-37f1deabda26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:5311","sources":[{"id":"urn:uuid:61d6f3fb-a240-4dd2-a87c-918e901dee13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q13563"}
{"id":"b50951c2-d80e-4005-920a-6ecae5107fed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2086","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:ae5044ce-e2de-4464-8ab6-c40c04c67d2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:145","original_object":"UniProtKB:P31388"}
{"id":"52af7639-09d1-490c-84c3-99e0cced3fb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54760053","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:83f2763c-b598-4b84-9ff6-8119550b42a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8095","original_object":"UniProtKB:P09619"}
{"id":"8d973d3c-f256-453e-b542-a02189b78210","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A62C114Q0Q","predicate":"biolink:affects","object":"NCBIGene:16491","sources":[{"id":"urn:uuid:fa58b120-5ccf-4c61-aef2-187f3b603044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2554","original_object":"UniProtKB:P16390"}
{"id":"5b0898f0-0077-4ed5-aadd-4d670fcb7b3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:0a0ff035-d6b4-4f87-a59b-4a41b0071bc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P28335"}
{"id":"5696f37d-2dcf-4fb5-9b98-6c320ea1b626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3699","predicate":"biolink:affects","object":"NCBIGene:8549","sources":[{"id":"urn:uuid:84df691e-9bfa-42be-b535-6bfde32ff1e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3699","original_object":"UniProtKB:O75473"}
{"id":"bcbdf187-a43c-40e3-adcf-757820c4d0d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10486131","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:431ccde0-6e3d-4f3e-95c0-d11dd908f97f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1621","original_object":"UniProtKB:P41143"}
{"id":"b8d673f1-a6f5-4328-b586-587f6f96c306","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11964458","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:5f026825-b8b4-403b-b497-5890b246bcb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3992","original_object":"UniProtKB:P36544"}
{"id":"c384d833-3a12-4f55-88a4-b33dd943b31e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71819307","predicate":"biolink:affects","object":"NCBIGene:12801","sources":[{"id":"urn:uuid:2ad33461-1f40-497d-8624-92ab497b41ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9239","original_object":"UniProtKB:P47746"}
{"id":"b1bff6fc-52ef-4d72-984a-a50881792edd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18388","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:1aa0d842-fd8a-4102-8fa6-477f14c8c29c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4136","original_object":"UniProtKB:P22303"}
{"id":"b2a9e693-1352-4a2d-9525-28f217f91350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177844","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:94c08ad8-87d0-44b6-b7b8-2b4bf2e6891b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10446","original_object":"UniProtKB:P28221"}
{"id":"22e52174-355c-4f4b-bb22-07641d5d165f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5593486","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:0dd31d85-3b20-4bb2-acc3-e47202fcfa40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12541","original_object":"UniProtKB:Q9NZQ8"}
{"id":"b0e309f8-2b0d-49e9-ba08-060292837605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1991","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:167d982e-68bd-4cf8-ae8c-092b692217bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1991","original_object":"UniProtKB:Q8WXD0"}
{"id":"88af21a4-4901-4912-9598-6c10130b6c83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:10804","sources":[{"id":"urn:uuid:e750f29d-0628-4dfc-9f98-557676b58c2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:O95452"}
{"id":"c551323f-e47f-4e12-b475-1a46ef4938ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11429930","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:ca94fda1-d6ea-49c7-9b89-db98ac495c8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:982","original_object":"UniProtKB:P30729"}
{"id":"76c8dd03-93b0-4fa8-8a35-f8f495a75fa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2950","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:cd5d8bb8-de3b-42b7-a1f7-8ffcd80aeede","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7121","original_object":"UniProtKB:P35367"}
{"id":"3521b76d-d6cb-4e32-b1da-81ad6508b80a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2561","sources":[{"id":"urn:uuid:4c00ccc2-a7a6-4e26-8a55-79b63ad46f5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P47870"}
{"id":"f5bc2605-ae75-4e65-abc0-8c9af3d211c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11698643","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:3ff7bc48-a666-4485-b22f-e13c7e7b662e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6125","original_object":"UniProtKB:O43603"}
{"id":"299b3566-20ed-4120-9931-0442edee9e09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51141","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:0032532b-f42f-435a-9783-d242a3bc5b0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7109","original_object":"UniProtKB:P25100"}
{"id":"d1a32b5b-b08e-459b-ac65-295931725d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1048","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:c8b26b82-718d-4e8a-8478-2502caf817b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1048","original_object":"UniProtKB:P21462"}
{"id":"4e472889-6dfe-42a7-8c0b-110eaff6cf77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:a9dd1c8b-556d-4323-8c18-f790d5e50bea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P28223"}
{"id":"e512bff0-f0fe-422f-ab9e-1ba09c94dfba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2NDX4B6N8F","predicate":"biolink:affects","object":"NCBIGene:933","sources":[{"id":"urn:uuid:94a531d4-b4b4-42c0-aaec-e1cc08bda71a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7675","original_object":"UniProtKB:P20273"}
{"id":"403dd1d5-cea7-44cc-9cae-9481d1f372e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221375","predicate":"biolink:affects","object":"NCBIGene:9020","sources":[{"id":"urn:uuid:a759abe5-e892-4c5e-b918-dd827d692b9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8174","original_object":"UniProtKB:Q99558"}
{"id":"ddf29659-3115-4182-be27-f308fd4a3824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:918","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:252735e5-6449-4364-a39f-4456b64c6706","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:918","original_object":"UniProtKB:Q13324"}
{"id":"f514a52c-4600-4224-af54-80732c37e597","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92361","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ce99e33e-ea59-452b-8e4d-2045a01238e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:405","original_object":"UniProtKB:P0DMS8"}
{"id":"cf15a747-9719-4fc4-87d4-64a18cc44ad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130169","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:45274006-4103-4fdd-8d7e-280b335d17a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:331","original_object":"UniProtKB:P20309"}
{"id":"b5b8d171-f112-4e5a-a387-6ed4c03d0031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140936","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:a8fdff23-5f14-4c62-b1f9-ac739f2563ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:221","original_object":"UniProtKB:P28335"}
{"id":"c012a12b-289b-4dc6-8156-1349961ff77e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:387f085d-3e00-4c07-8699-e89e91ea020f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P24941"}
{"id":"b6c0898a-3474-404a-a1ce-8658e05cb7d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699442","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:22babb63-23c0-4a0b-ad02-c413e54b2a44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11099","original_object":"UniProtKB:Q08499"}
{"id":"db07ae60-41b0-47ea-a5d3-7ade6d067e66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231425","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:ae19bef9-1c74-49b9-9e7d-c8a48d9f3727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2226","original_object":"UniProtKB:P37288"}
{"id":"319fb9aa-8b79-481a-a0b5-9f1000a71bc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841284","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:c68fddd9-2c4a-425a-b678-b9d5bd21b8c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:423","original_object":"UniProtKB:P0DMS8"}
{"id":"003731d7-6ca4-406d-acd4-a2dd0064f962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G2AE2VE07O","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:35a70d2f-72e5-4c15-8da9-4c9cf0a34c5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10129","original_object":"UniProtKB:P08173"}
{"id":"7cf279ab-f6c3-4b4f-8409-cfcaeda9ac7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24863112","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:f3cb11df-bf11-4a20-91ba-3b2b96ad8b93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8205","original_object":"UniProtKB:O75116"}
{"id":"89f5a776-af66-449f-934d-91a0fc108981","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3084441","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:ec9927d3-90b5-4724-8d2c-3171cc4f0b05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3725","original_object":"UniProtKB:P32239"}
{"id":"71c3e5c5-a8f7-4480-b113-edf8fdfee09e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8982","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:5622f0f2-010e-4db0-be3c-a2716c298873","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8982","original_object":"UniProtKB:P25021"}
{"id":"8f0f1340-8a82-4b20-888d-7b33d4c1aa9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947515","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:f12ba8d0-6cf9-407d-9333-218b9c977c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9916","original_object":"UniProtKB:P37023"}
{"id":"5b0cb0e3-0057-4653-bbc3-2c29ef39e704","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28119","predicate":"biolink:affects","object":"NCBIGene:196","sources":[{"id":"urn:uuid:71986d95-1d95-43a4-9a62-028d938241dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9642","original_object":"UniProtKB:P35869"}
{"id":"78ce1b5a-77af-4497-9413-5a9144274e31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827358","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:68ca2dfe-a9c0-405e-ac1d-d6a273e1951d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8395","original_object":"UniProtKB:O14744"}
{"id":"7ce19611-fef1-4fd3-8af9-a576127168ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6195","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:74be84d3-f482-43c9-91bb-a5ad83135db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6195","original_object":"UniProtKB:Q9NS75"}
{"id":"c25ea0b3-7974-4643-8bcf-ee1dde3aee5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102061602","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:796ffd91-747d-4bfb-b5f1-089e45a1287d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:647","original_object":"UniProtKB:P46663"}
{"id":"817212b2-f1ef-4e39-a691-60edd7283153","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24743975","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:cb9f5115-210d-492b-af8c-5317787af9ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5805","original_object":"UniProtKB:P47900"}
{"id":"ad44eb9d-d65d-4e10-b7aa-9bfae44d2818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699460","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:debef537-6ba6-41ea-a5a7-1073edd57826","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11216","original_object":"UniProtKB:P0C6U8"}
{"id":"0c61a098-8468-4955-8209-a0c13b4888ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23786507","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:b51784ce-71f0-4e45-91e6-c39e4c48e215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:178","original_object":"UniProtKB:P28223"}
{"id":"8ff658f8-ee03-498b-9a32-2710c0e93b3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:67cd82fd-3dbd-4946-808c-99121a15a35f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P08912"}
{"id":"e6cf3129-b6f8-4d69-83c5-a11168c8afd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78549","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:29541204-2224-4fed-9ca8-d35641fcd4c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:92","original_object":"UniProtKB:P35367"}
{"id":"6f076c16-832e-41ea-90ef-9ef5fbe91558","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:1d43ba26-2cc4-410f-80c7-9f6806645fc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:Q9NY46"}
{"id":"2906a2cb-3e77-41d2-91fe-379fb9db13a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48574","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:9e087ffb-6023-4a81-9377-35b34b3af20b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7270","original_object":"UniProtKB:P35354"}
{"id":"a9ebba28-0d41-43e8-8e34-5f7642a582a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:18596","sources":[{"id":"urn:uuid:310c78ca-1480-40ee-abd5-5eb80c90f492","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P05622"}
{"id":"e196c555-d3e0-4624-afe9-2675eb00a115","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59896759","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:726fb618-f508-47a4-a9ff-fe391e15b374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4369","original_object":"UniProtKB:P47869"}
{"id":"c37aa452-90c2-402a-94fe-eed2e996d063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232500","predicate":"biolink:affects","object":"NCBIGene:706","sources":[{"id":"urn:uuid:e6340631-c439-47cc-a5ed-741d337a475e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8704","original_object":"UniProtKB:P30536"}
{"id":"0bab7650-2dbf-4659-b1d0-0049a9b805dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53323294","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:0d722f00-351f-468b-b57e-78b6ab689979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1076","original_object":"UniProtKB:Q9Z0U4"}
{"id":"641d1f6d-dd37-4734-9ed6-175a29b3de5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10111831","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:2076c6dc-dae4-4593-b5ee-a52107db51cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1942","original_object":"UniProtKB:P32240"}
{"id":"7c77af1a-a1ba-458f-b1ce-a7058d66105a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:84630","sources":[{"id":"urn:uuid:547fd224-e7bd-4c9c-8c83-fdb9365e7bc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q5TCY1"}
{"id":"f71b0fe2-0983-42c5-ab6e-0be01d6e0d46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119081688","predicate":"biolink:affects","object":"NCBIGene:24598","sources":[{"id":"urn:uuid:d4ab9f5c-d3ab-4d0e-9fe3-e6135746e200","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9147","original_object":"UniProtKB:P29476"}
{"id":"5593221d-a313-40af-8a98-27546a798ee3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27436","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:709501f2-0a67-40de-9e2b-b1c23de0587a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6945","original_object":"UniProtKB:P10275"}
{"id":"2876ca2e-e20c-4de6-b3dd-764a2b34325d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813895","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:388b1463-2beb-4e1b-9468-8a0814dc8681","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8349","original_object":"UniProtKB:Q9HBX9"}
{"id":"b05da34a-8938-4652-98a7-f04585c14861","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:339LBH1395","predicate":"biolink:affects","object":"NCBIGene:29571","sources":[{"id":"urn:uuid:58021f88-9dec-429e-b3f0-06370b97b4e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:5734","original_object":"UniProtKB:Q62968"}
{"id":"8de8a736-5525-420e-99f5-6a7e7ba234ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70735","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:4ee1cbe9-5e6b-4f18-9486-afb10198674e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7461","original_object":"UniProtKB:P61169"}
{"id":"09868da4-11d5-4a3f-9ff1-2dc194739da1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34605","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:722da8ac-e258-4f69-8e52-9eb33a0440d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4165","original_object":"UniProtKB:P48058"}
{"id":"de37cab9-73ad-4df9-b2b8-ede3d8cf550e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6911854","predicate":"biolink:affects","object":"NCBIGene:5726","sources":[{"id":"urn:uuid:43bdf7cd-f608-40a1-8a77-04700295778d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12456","original_object":"UniProtKB:P59533"}
{"id":"b53d0e9f-58c5-4464-a771-f3500961fcc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64317","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:c1691a2c-e7f1-4cf5-824c-c157362509b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:536","original_object":"UniProtKB:P25962"}
{"id":"7937bfcc-0e07-4a13-8461-8f27f17ce969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3082","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:87bed19c-3790-41be-ba87-2eddd6d0db7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:549","original_object":"UniProtKB:P08588"}
{"id":"7001f7a4-da0d-4794-96d7-9eb18dd368e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34018","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:e143075c-6d54-4481-8d05-120055307fdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4131","original_object":"UniProtKB:P42261"}
{"id":"33bb5cb5-751e-45fa-be08-00774875dcde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90202558","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:856a8eef-72f4-4554-b99d-c62593338bef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12783","original_object":"UniProtKB:P35408"}
{"id":"7eef8695-79a4-483b-99a5-5ec8a6d90e54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:d08bc76f-8c74-4f80-bdff-df46aca6095d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P28221"}
{"id":"cc2182bc-043b-4263-825d-0f9197a4f106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93112","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:6abc134f-e86b-4869-a3f7-98d77a87fe14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:750","original_object":"UniProtKB:P34972"}
{"id":"481b920c-3577-4024-ac30-5c820da05271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:165313","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:4e3c9dfd-adb9-4312-8991-96c9f8d419b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1947","original_object":"UniProtKB:Q62928"}
{"id":"e0acf1e2-f4b8-4ae7-b3d2-765491e2a5b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7582","predicate":"biolink:affects","object":"NCBIGene:778","sources":[{"id":"urn:uuid:a8d06f34-c42a-4904-8e64-e1fcac18f5d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2334","original_object":"UniProtKB:O60840"}
{"id":"59adbdc2-486b-44a9-806a-c8012d32bddc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:c378c924-d75a-4080-b179-b38d799120ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P50406"}
{"id":"2de7c04e-4c93-47a7-a1be-d3c78ceb4918","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17580","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:8ec3e54b-1026-4e59-b2d1-deaca21bfa05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2469","original_object":"UniProtKB:Q8R4D5"}
{"id":"7916fd19-fc8e-443c-b74a-8a0439c41849","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5262","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:022292ab-3660-48e6-857d-7263a9660714","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:410","original_object":"UniProtKB:P0DMS8"}
{"id":"d7054324-6ec2-49c4-bf3b-c8db9ecff60b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4c040270-5316-4350-948c-9abf0d55394e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P28223"}
{"id":"f6707b5c-2b19-4207-8391-7269ff98dbff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6116","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:20c08917-2ab5-45e0-bf42-012aa9efd981","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6116","original_object":"UniProtKB:O43603"}
{"id":"df5e7b84-65d6-4bf5-9fe4-68d0baec24bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:59XC9G796Y","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:bdfb2590-9e66-4131-8730-a13677bc48a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12302","original_object":"UniProtKB:P11229"}
{"id":"583b096a-226a-462c-b5de-072770048945","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:5481","sources":[{"id":"urn:uuid:f1b9840b-4f12-4b62-837c-e70ce49ede3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:Q08752"}
{"id":"c499011c-b1b0-4be2-889c-b11b7b48a414","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:116314","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:1e42cdfe-2f89-4c71-bcd9-f63983b68ccc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:284","original_object":"UniProtKB:P34969"}
{"id":"b8a42ece-a673-4a0d-b23a-344bb5042830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9952446","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:c713ee28-7eda-4bc0-8790-8f538bbb0804","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4251","original_object":"UniProtKB:P42263"}
{"id":"acfce145-9f5a-4160-91c8-48297919268b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:169876","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:3fd1d8bb-60c1-49ce-b823-a9973b68663f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10204","original_object":"UniProtKB:P11511"}
{"id":"d7476443-39e4-452e-96a6-74c565c2ef6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45II35329V","predicate":"biolink:affects","object":"NCBIGene:50507","sources":[{"id":"urn:uuid:53a0be2c-d0c5-48e7-a1ad-9979afeefa7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9932","original_object":"UniProtKB:Q9NPH5"}
{"id":"e19eedaa-b70f-415f-b72e-bb74daa9eb38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SA2ND7EHY4","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:227343e1-ac64-4374-871d-5ed56b448e7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8836","original_object":"UniProtKB:P06239"}
{"id":"6d041a58-88cb-49ce-827c-8715cd11e564","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:d165c046-83fe-402c-b407-392bf6e8ed26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:316","original_object":"UniProtKB:P11229"}
{"id":"74e53bae-1894-4d59-932a-b07cc173d5d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593562","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:d9cbca54-ca76-43d7-be5a-6a68f69fdb7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10531","original_object":"UniProtKB:P11802"}
{"id":"acb8263a-c9fa-4ea6-b859-008b4946a822","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28077","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:a65c8415-ffc3-4f89-ac6f-09b74660024e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2765","original_object":"UniProtKB:Q9NPD5"}
{"id":"ba4656ad-539a-41a3-b252-e592d2a074e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24771259","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:ea4d88b0-422c-40ce-8d0c-47c01277722b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6986","original_object":"UniProtKB:Q92633"}
{"id":"5f1960cf-55e4-4c53-b217-d605ca85cbb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50692","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:a8ea5601-3db3-4cf9-97c9-bb0a02f5e955","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2805","original_object":"UniProtKB:P04150"}
{"id":"0fa28368-0e6b-499e-8a39-6ae3122ecd3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14851316","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:2a7ae1ed-c5a1-4711-bdc3-dc69dd0c8bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2984","original_object":"UniProtKB:P04035"}
{"id":"74e01532-0711-4a79-b8a2-987962ebf90f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813889","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:02243e59-2a34-4add-b430-ae5d4f18b846","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5391","original_object":"UniProtKB:P47211"}
{"id":"f6ce399e-2147-4ea7-91c8-e0fafcf0ee8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9845965","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:a35cac20-d0b3-42b9-9d90-06065dadb74c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2697","original_object":"UniProtKB:P37231"}
{"id":"2f1019ab-ec80-4f89-aab5-6af4935e2eb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086547","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:bd8d492d-c3a1-42f2-bbed-d81767895673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:244","original_object":"UniProtKB:Q13639"}
{"id":"ac315aa9-b6d3-4fb2-8735-7e0bf9bca3d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2615","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:5f95efba-1af1-4a50-a39f-78ba259bf05a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2615","original_object":"UniProtKB:Q9UQD0"}
{"id":"d2a2adec-0a40-4672-972d-5242ff48f5ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:714665c3-54ef-4670-9c58-d1434ec4b8b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q99571"}
{"id":"c9abcbf0-cea5-435c-bb4a-f4072ed14d06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:5644","sources":[{"id":"urn:uuid:9e6632d9-a034-4f03-bbce-8e23307a762d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4262","original_object":"UniProtKB:P07477"}
{"id":"09602148-a6af-482a-aaf5-af39b9e8a352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5XE882529E","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:2f9d5b27-68b7-4e81-894d-970a9830bcc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1009","original_object":"UniProtKB:P24530"}
{"id":"29dd0ffc-b953-47dd-8f16-27d744435003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NY0COC51FI","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:78ce1c2f-da39-4c5c-9f6e-f5f287187f15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9278","original_object":"UniProtKB:P25103"}
{"id":"49943dd9-95a0-45db-92f5-9f12b801f077","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16761","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:5ccfd0da-1529-444d-a0ab-d96f7ab1c2f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1712","original_object":"UniProtKB:Q9BPV8"}
{"id":"df6dd7fe-21b0-4ce1-b5fa-d902b499f80e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:330cdcb9-ac24-410f-9490-faa010857666","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:Q60614"}
{"id":"86ee1ab9-3f25-4eb6-b1f4-f8f6be47a4df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188583","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:2097b88c-b6f2-408b-8315-89a68aa804c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4221","original_object":"UniProtKB:P14867"}
{"id":"743bf6dc-b59d-4b8b-95e7-b07fe6821b8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755145","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:3824c005-ffa8-41f0-957a-18bee38aaa90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5712","original_object":"UniProtKB:P09619"}
{"id":"3b230c30-ef97-4c2c-aa43-4c9d2317ed5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1108","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:3b69562a-9d67-4d9f-9f8b-086b3a74d2d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1108","original_object":"UniProtKB:Q02644"}
{"id":"f0ba5841-0973-4608-9a1c-ccfb1ddc4736","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73274","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:55a35c17-23f4-437e-b7bf-9bc87363ef17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4582","original_object":"UniProtKB:P13866"}
{"id":"d71fd15c-a2a9-4361-be3b-b04fc9a12024","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9601226","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:17cfa115-b620-4e97-aad8-a944ad1a886f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6456","original_object":"UniProtKB:P12821"}
{"id":"510b38ff-c570-4596-9bca-b6188f9a2bd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:10052","sources":[{"id":"urn:uuid:c88fcfd9-e782-463e-9137-35e1b992efb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P36383"}
{"id":"0d601a8b-be61-42b2-82d4-39a03c44f63c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13892139","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:c5128219-b144-4502-83ca-c753a5e2d8f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11855","original_object":"UniProtKB:Q8NHX9"}
{"id":"4b48d44e-2a8a-482e-9943-403f54c75644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71245042","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:c5c8ae09-f6b7-43fc-9d2b-8e88819c17d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8897","original_object":"UniProtKB:Q92731"}
{"id":"db757eda-fa75-4a8d-b646-337be74c0a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:849","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:795bc7e2-75dc-4e4f-9848-20564851222c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:849","original_object":"UniProtKB:P61073"}
{"id":"44c0321b-8707-4962-9e19-29bf06964940","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91327","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:f442700c-3659-4b67-879a-8026249210b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6058","original_object":"UniProtKB:P17948"}
{"id":"07847b64-7119-4262-942c-d42f30026174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58525066","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:4ff72316-0887-42fb-91b8-09c47dee329d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9692","original_object":"UniProtKB:P42345"}
{"id":"c26fdc42-cd9d-4349-b787-920ee0c3404a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11532283","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:c32b0920-5d8c-4b2c-b7d6-4635a31894ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4313","original_object":"UniProtKB:P13569"}
{"id":"76727110-ac63-477e-a4b2-e588fbd20888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34968","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:16925a91-b5d7-4f5e-9987-8688ac36952c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4197","original_object":"UniProtKB:Q16445"}
{"id":"8ba49ced-74c9-4092-8ff4-a0fe63106d23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2521","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:e48bc898-99b8-4b3b-a5eb-3ae11404e5ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2521","original_object":"UniProtKB:Q02294"}
{"id":"9024cec9-2c2c-46f8-a280-bace6f308427","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JT21Y57650","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:f95d57b9-9244-4502-83dc-e603cacf77b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:626","original_object":"UniProtKB:P30550"}
{"id":"aa5bd93f-e78c-482c-8d0b-d1097e77dcac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755029","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:68f49674-f3f8-4df2-9ab8-673ce0284ae4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2962","original_object":"UniProtKB:P51639"}
{"id":"e84ea2a0-b37a-44fd-8425-e16c85a3f0f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:0fb472f8-e834-48a9-a9dc-1570c3027b81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:P30874"}
{"id":"93cfd714-8fc3-4724-9012-40298f5189f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6256","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:5f3a4821-5989-4046-8a2f-8d70ad6a6138","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6256","original_object":"UniProtKB:P31421"}
{"id":"a09b93ab-d93c-417e-8751-cb4d7cd7524f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88353","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:b2ba0af3-2f98-4714-be2c-998812494a11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13773","original_object":"UniProtKB:Q05655"}
{"id":"0d92e89f-d031-4c1b-83f6-464abe14abcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:754a576f-8d15-4933-a419-bee153f172d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P28223"}
{"id":"9c361a9c-9bf8-4485-9cc0-836a7ff97aaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6804","predicate":"biolink:affects","object":"NCBIGene:462","sources":[{"id":"urn:uuid:8156d4ca-b44c-4ca8-b214-3a6ca46cd99a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6804","original_object":"UniProtKB:P01008"}
{"id":"5e2bbd5a-04af-4727-9fac-8a34c4a9c685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:f48857be-e7d8-42f0-b8c2-0986da4ebc9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:Q13255"}
{"id":"3353c3b9-6920-4b3a-9daf-84ea24978f7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:bccc3987-9f81-4199-a169-32d27270e26e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:O88626"}
{"id":"1a58d6b3-ae22-4fb9-9ac8-12c6ef17b1d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94385","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:9108cd1a-9d17-4571-b52d-11cb62d086a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6385","original_object":"UniProtKB:P00734"}
{"id":"13bf556a-3073-48bc-86d8-d8f73ce2eedd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:63V8AIE65T","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:464c0d0d-00c7-47ef-8968-de08b3e87209","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7972","original_object":"UniProtKB:P40763"}
{"id":"7c61dba5-34b8-4f8c-86f5-543b531466fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1331","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:56331c31-d2ea-41a4-95c4-8af2f5319bd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5246","original_object":"UniProtKB:P35228"}
{"id":"ab5a0e6c-cc1f-4def-bac7-e58b30144826","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9UP25GJ6E","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:b7a6e570-41b5-4c23-a19e-8770e6dbf744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1259","original_object":"UniProtKB:Q9QYN8"}
{"id":"3bf60f82-5c52-4906-bd48-7c2f9d00362c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623362","predicate":"biolink:affects","object":"NCBIGene:4314","sources":[{"id":"urn:uuid:e3a966e1-51df-47b5-984b-3785f952eb31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8259","original_object":"UniProtKB:P08254"}
{"id":"3633579c-e927-4eea-a56b-d291b6c52290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4764","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:e0185125-a59d-41af-87fa-0e6bd55fed2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4764","original_object":"UniProtKB:Q05940"}
{"id":"012eb35d-f031-4341-94d9-4ab1f93ecd31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:329954","sources":[{"id":"urn:uuid:cf49e8e6-ff54-4ae8-8c01-a06b906101be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q8BVN3"}
{"id":"2a39680a-ae63-40c5-82bb-2ffd1597f93d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b8632855-3b88-413d-bfb1-41f01719a6e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P08908"}
{"id":"f08d3fd2-52bf-4927-8d28-163199f5c411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23452327","predicate":"biolink:affects","object":"NCBIGene:310645","sources":[{"id":"urn:uuid:d7427620-cee6-4d6c-8df6-15db38258d4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3202","original_object":"UniProtKB:Q5RK24"}
{"id":"0ac8a7ff-e6c7-43b7-9e89-8eff4454ef3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2742550","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:b9641c3e-0487-424c-a33b-2ee50f5f8b5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4213","original_object":"UniProtKB:Q9EPK8"}
{"id":"39b8f0a5-1871-4461-9b71-e5979688e263","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2260","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:9dea1671-63a6-4130-89f4-bd0de328a4a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2260","original_object":"UniProtKB:P41586"}
{"id":"28d3c334-bfb9-403c-b835-6142fc0e78c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54KY638G8W","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:a6bbd38b-e130-4ece-94f7-0ea5bd89e988","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2633","original_object":"UniProtKB:P10828"}
{"id":"1e1d8aa9-f39b-4b1b-8021-1b1500117339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85966","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:6d3d81d5-53dc-485d-8317-b699c46a809f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2357","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"992ad286-332b-488f-ae0c-9198db2cfd2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231616","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:31605e89-dcba-4483-88ee-1d9127bf001a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11647","original_object":"UniProtKB:Q13535"}
{"id":"785d5d4e-960c-4620-ba82-81d07bc27c72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34823","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:c6f574f1-64ea-4a48-930e-d0b51cb6bf4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2599","original_object":"UniProtKB:O43526"}
{"id":"9a957b89-154e-479f-a7d4-35c6b9d77197","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6100","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:7b5be038-b996-4db6-8f8f-9f375f9ec31d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6100","original_object":"UniProtKB:O60755"}
{"id":"f08b0a03-a7e1-4979-80ec-d750e4d90ad7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:752812","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:ee126e94-ed29-4812-b90e-0fa5a55e7e20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9459","original_object":"UniProtKB:Q96RI0"}
{"id":"e89aa206-0862-4138-8f51-9e7d0a18161a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1989","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:7c38eded-098a-4fa1-9db3-2e592af5776c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1989","original_object":"UniProtKB:Q9NSD7"}
{"id":"9b079f66-7dca-4185-9320-c78183b4fc28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155884467","predicate":"biolink:affects","object":"NCBIGene:5305","sources":[{"id":"urn:uuid:cd3a6bd5-bd5d-43f9-919a-d1922928143f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11793","original_object":"UniProtKB:P48426"}
{"id":"0f98db7a-91d7-4518-8259-7ef0632085ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72706837","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:ae65b0fd-022e-4ccc-b3f4-18bbda97fc24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8295","original_object":"UniProtKB:Q5S007"}
{"id":"558db1af-0028-47e2-a997-0f7d048ae24d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:615K7YBS59","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:af6503de-4118-40c5-9b9f-addb96ef7960","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9476","original_object":"UniProtKB:P41180"}
{"id":"534b237d-807b-420f-88df-7aefa4f893c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13725","predicate":"biolink:affects","object":"NCBIGene:3575","sources":[{"id":"urn:uuid:101ee63a-2e58-4f77-ba05-7bc78813976e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13725","original_object":"UniProtKB:P16871"}
{"id":"5f1de0c9-f252-461f-a079-ba3ad7dbcd10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92503","predicate":"biolink:affects","object":"NCBIGene:5140","sources":[{"id":"urn:uuid:fb50f82a-6a62-4381-b521-bf0057e99782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5167","original_object":"UniProtKB:Q13370"}
{"id":"31a42d9b-386f-4a80-b71c-3957120bc2e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TE20GB753F","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:2c2198c0-bb18-48db-a5ad-51e2d8ab91e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9930","original_object":"UniProtKB:P35968"}
{"id":"9e98a8f8-6d17-4c2f-bc86-700c9a658f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16144017","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:1d97075d-7cd0-49a7-94d2-351da276a981","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1822","original_object":"UniProtKB:P70555"}
{"id":"6841bb4e-4178-423d-9fa1-5c8b2b89e404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6095","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:4ba679e6-17cb-4142-8f78-6476da366e8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6095","original_object":"UniProtKB:O60755"}
{"id":"89039c56-14c5-45bb-9875-e7dad57795f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:b651e0f9-efeb-493d-90e2-3974acdb1349","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:P56479"}
{"id":"ba395c58-c941-4c92-81f3-7312ef8739b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:56babb97-3d15-450b-a2d9-4e9d750a7afb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:Q8NEB9"}
{"id":"6fb64f51-247b-4fec-9ee5-91406995e95e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95255","predicate":"biolink:affects","object":"NCBIGene:259293","sources":[{"id":"urn:uuid:2ff46038-eb8d-42d1-952e-6a1641cdf9a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12433","original_object":"UniProtKB:P59541"}
{"id":"b767d7ca-eba3-4854-9460-7e9fa344c365","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:6d6eefb9-f348-495c-bd8e-b8b2f42fab61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P31645"}
{"id":"36fd1964-d963-42f4-b4ae-673483cd9786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10475082","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:936e2955-53dd-4116-af8d-e19020cb0d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5591","original_object":"UniProtKB:P30542"}
{"id":"285e0d19-4a44-4843-9752-6d778c957fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:927","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:6d914621-fbd5-44f5-80a7-3499b4928c5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:927","original_object":"UniProtKB:Q60748"}
{"id":"190380ca-e9f3-4a90-8825-9c53e4eafe0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3654","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:c9168d21-8597-4d74-b9a9-5e05757833bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7147","original_object":"UniProtKB:P00915"}
{"id":"f26f27ed-2d7d-49bc-80bd-f935d6a54fab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:31M3WLJ3KG","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:512a7ea5-bcf5-4853-b9ea-604043750f53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11544","original_object":"UniProtKB:P04049"}
{"id":"4d52195f-8bcd-45ae-84bf-928b83826fe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B2K5L1L8S9","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:7528e48f-698b-4a03-9058-4ac505de443f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9769","original_object":"UniProtKB:P11362"}
{"id":"39d4151f-ebe3-4a1f-a343-66554d098dcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132837","predicate":"biolink:affects","object":"NCBIGene:24807","sources":[{"id":"urn:uuid:12e702ce-bddd-4658-b5a2-33bdd5455ae1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9461","original_object":"UniProtKB:P14600"}
{"id":"2dbdc703-0c66-4e5d-90c5-25ae8af01a83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:37825ec1-0847-4c34-9ebe-18d5112c458a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P36888"}
{"id":"ab02894c-b0d5-4ab6-a879-02beaf79bbea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:46D4HS9ODA","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:8c1c3a9d-fcd7-484e-b4a6-0a4894dfbd16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9903","original_object":"UniProtKB:P50750"}
{"id":"d6c5909a-e961-4854-849b-cf434cfd9b3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8762XZS5ZF","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:bda72199-f1a2-4d46-b680-cc994cc12fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8958","original_object":"UniProtKB:P15056"}
{"id":"a13011d2-4673-4b81-af7f-1769b1ce523f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:08ae8a56-b0f1-4d27-b04d-17effdb1c9b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:P11362"}
{"id":"acd79349-246e-423a-98f1-5b98e67d232c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57381425","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:2fd5e0c3-9d50-48b9-9612-c67f0c611c90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11120","original_object":"UniProtKB:Q92769"}
{"id":"08d1f64b-8952-4b71-b523-e12e14dba290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755216","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:66b967d6-af2c-4078-87b8-69e76dd693a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6371","original_object":"UniProtKB:P31424"}
{"id":"32a8ba3f-3965-41e3-9015-02d22538c64f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3811","predicate":"biolink:affects","object":"NCBIGene:24807","sources":[{"id":"urn:uuid:4559e0d3-e45e-497f-b2e3-f1689ac35219","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3811","original_object":"UniProtKB:P14600"}
{"id":"74376e81-32b2-4db2-bc1a-988078c94836","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23657507","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:a6da85f7-7a2f-49f1-9b2d-c97a9e94ed88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8146","original_object":"UniProtKB:P07948"}
{"id":"e8a359f6-c455-449a-9d29-fb951903d2a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15780052","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:a299c92a-f418-4e84-a837-c161c8712ec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11930","original_object":"UniProtKB:P50052"}
{"id":"f81b6d57-cdd4-4d05-ba4d-6b8798ed12f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1496","predicate":"biolink:affects","object":"NCBIGene:2832","sources":[{"id":"urn:uuid:f855ac07-c26a-4b97-9e24-f0cd008e5f70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1496","original_object":"UniProtKB:P48146"}
{"id":"769ce1fa-e45e-4173-b5b7-e7749ff60bd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:c15727ee-a938-4dae-9fdc-0bdcfb0c5c33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q92769"}
{"id":"f76e2440-7cd9-4c09-a71d-1bbd61b7e5ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:157","sources":[{"id":"urn:uuid:42b48049-3534-4b95-9530-29cc2d420943","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P35626"}
{"id":"1cfbd571-5836-43aa-bc20-16a162944ff9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80271","predicate":"biolink:affects","object":"NCBIGene:9340","sources":[{"id":"urn:uuid:35225d39-11d9-43cd-8c4a-d41ad9ae43f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1140","original_object":"UniProtKB:O95838"}
{"id":"957adb9e-d464-4448-b104-6fbff241f3b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3305","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:a505d84e-199b-47bc-afc7-9a7b37ed56e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3305","original_object":"UniProtKB:P41586"}
{"id":"adbc69ea-d2c2-4a94-b5d6-3db64dff79fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57861407","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:8dbc8e86-94fe-4afe-99f0-4f2ac23d2810","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9717","original_object":"UniProtKB:P34913"}
{"id":"71feedb8-8a27-4f83-8c63-8559c542f3e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95015","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:c7473b9a-8123-4d4e-9606-b3e650ee39b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5207","original_object":"UniProtKB:Q99685"}
{"id":"05a05cc1-ebcf-4859-95f5-d91a0cad51c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57381997","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:e983a323-c9dc-41bb-ba69-dfe795831b5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7781","original_object":"UniProtKB:P49286"}
{"id":"f042625a-d45b-4341-a032-037e3eb4d9b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147817927","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:4789dbdb-0efa-4385-9167-7fa9a34c1e34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12080","original_object":"UniProtKB:Q9NWZ3"}
{"id":"ae856801-4b23-4dc3-9ee9-c79ecd1ea9a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233446","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:dd155944-97cf-4d80-80ac-daffe5d6581c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:12630","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"3d321e5e-6626-410a-8f57-019c31c322e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93911","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:6e55c67b-ec76-4669-999a-f535bf45aae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3396","original_object":"UniProtKB:P23385"}
{"id":"7b7a89c5-76e1-47d2-b0a5-7d76510ceeaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135470","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:987ff422-1e7c-4c10-a43f-e74763eb00e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:501","original_object":"UniProtKB:P25100"}
{"id":"c087d780-310e-47cb-94d0-6a8cb7b1bbde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146466271","predicate":"biolink:affects","object":"NCBIGene:8525","sources":[{"id":"urn:uuid:eb219346-8a52-4413-b7f2-901855168d59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13006","original_object":"UniProtKB:Q13574"}
{"id":"11c80e7f-c559-4e61-b240-053a8d0d6188","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2541","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:86d50510-7f76-4925-96e2-f44ed8efe20c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2541","original_object":"UniProtKB:P54282"}
{"id":"56ff38ba-6dda-495a-8f98-b0a27d70a545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:dd363554-2418-4368-aec6-fd30a3e94751","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:Q92952"}
{"id":"c7092cd7-316f-4f28-a343-0af72339eb68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135761798","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:3dca639e-2e63-4111-bac0-00f6abddfa0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8218","original_object":"UniProtKB:O00311"}
{"id":"56cf135e-bb36-48fe-b755-eb72713ca858","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86764579","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:135cd5c3-b3a0-4a7e-88e1-ba875f19d98b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8733","original_object":"UniProtKB:Q08345"}
{"id":"4cc492e9-51d3-4ed5-8aa8-0708c2fbb783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10458325","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:f09c69f8-a9f9-4402-811a-1838301d4cb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7944","original_object":"UniProtKB:P35916"}
{"id":"27d5d39d-8c7f-408c-88fc-88167f70fb28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85403","predicate":"biolink:affects","object":"NCBIGene:2857","sources":[{"id":"urn:uuid:4f24ce84-30b3-4876-83c7-6adbb082008a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4064","original_object":"UniProtKB:Q9UPC5"}
{"id":"55bc345d-6225-4edc-b13c-4f8893405d01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132509","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:0c1477ff-8e3b-448a-b133-62ef2ab15b0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9392","original_object":"UniProtKB:O60674"}
{"id":"94c1b2dd-34f4-4644-81d5-473298b17b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27953","predicate":"biolink:affects","object":"NCBIGene:590","sources":[{"id":"urn:uuid:5baba01a-f95d-4565-a7e5-2c0b58c1444b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6598","original_object":"UniProtKB:P06276"}
{"id":"30731024-f261-4f0b-83ff-90b98441f147","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78330","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:bbce1307-cc92-4ace-842b-d3b0f789d0f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13727","original_object":"UniProtKB:P22303"}
{"id":"3cbb4744-a7c1-41e7-8184-0284b8f28a40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9622","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:d518e2a0-21a6-4289-971e-458d7d74ab41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:360","original_object":"UniProtKB:P20309"}
{"id":"d41fffbe-0dc9-4e46-8862-66d0b94359f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:91D8378G2V","predicate":"biolink:affects","object":"NCBIGene:121278","sources":[{"id":"urn:uuid:549fbf0e-f287-4342-9c48-2e825434a0f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10647","original_object":"UniProtKB:Q8IWU9"}
{"id":"172838a9-8638-4461-9010-931db541fc25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49840","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:e4d2fc37-3032-42de-8a5c-84dd9752b9bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7806","original_object":"UniProtKB:Q00535"}
{"id":"d7126666-8d3f-47a1-abb4-3ec2411f898f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16661454","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:2f73303f-abb5-4bac-a187-678a21a682ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7056","original_object":"UniProtKB:Q9UBN7"}
{"id":"50898f32-cdcf-4fac-96dc-7112b10a9bf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801157","predicate":"biolink:affects","object":"NCBIGene:604","sources":[{"id":"urn:uuid:7c1ee0a4-f5f8-4ce3-aac0-c932232cb418","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9672","original_object":"UniProtKB:P41182"}
{"id":"e48d2a33-9419-49e1-9737-9651e172463e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44250176","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:4fc64c34-b56e-44a5-9a7d-df4584e8a0fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5800","original_object":"UniProtKB:P49019"}
{"id":"70137579-a496-4e25-a8f5-9e907586cb20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0Y25DT968Y","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:a8b566bf-e281-4f2f-bd80-9f868813d613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4590","original_object":"UniProtKB:Q99808"}
{"id":"10cd2859-bdd2-4b48-8dfd-cda5ccf1199d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56593118","predicate":"biolink:affects","object":"NCBIGene:11313","sources":[{"id":"urn:uuid:9cba1922-f5b5-4729-9f2b-1cfda04289c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13415","original_object":"UniProtKB:O95372"}
{"id":"5634fb5e-ca82-46f6-860e-38fa6611538a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176334","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:17a33faf-648b-4313-ae1f-9f9c91cc6c51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9116","original_object":"UniProtKB:O60341"}
{"id":"c5e4cb48-4af2-4b4f-9be9-e750e41c242b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194548","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:8a017f89-be07-4c30-ad2a-33d3dfed28dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:509","original_object":"UniProtKB:P26255"}
{"id":"a072d480-5023-4d92-82dd-c840a7fbe402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94449","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:8e4070f9-3ab0-4c93-bf07-ea4919ec209f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7459","original_object":"UniProtKB:P08912"}
{"id":"c65c02d7-67ad-4db1-a4cd-0b8d33eef9bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:52H8DB0TKX","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:fe591952-e30a-4a4c-af76-2982e12920d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3462","original_object":"UniProtKB:P13945"}
{"id":"40084cbe-e3cb-4522-b4b4-3f67da5ec1c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16118119","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:403509ad-fd91-44a5-ab4e-2074e5cce558","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6356","original_object":"UniProtKB:Q13255"}
{"id":"b5ae50fb-5dba-48fd-8d7c-1a7f85d086a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f1f90279-15d3-4b11-b91a-f6d886d4f790","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P29274"}
{"id":"4318653e-423c-4a1a-a4aa-3ad0458dd2fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4R0136W1PR","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:c7040b69-7906-470a-983a-f3bb0ebc2e3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4033","original_object":"UniProtKB:Q99705"}
{"id":"0cd34d9a-99c1-4345-b702-20c48cf04f5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8GU4PSP29","predicate":"biolink:affects","object":"NCBIGene:5152","sources":[{"id":"urn:uuid:723c059a-5e24-4558-ab4b-efcd79caa5ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5270","original_object":"UniProtKB:O76083"}
{"id":"1ee6dd27-1d53-40ac-894d-042d65a9f1d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868452","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:e567e4ff-a08d-4786-9fbe-70fb2e644ec2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:129","original_object":"UniProtKB:P28222"}
{"id":"030ba74b-a756-41e9-a9e3-3872a4130acc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172845","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:86e4df5d-47b7-470c-9f34-44860a360722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1026","original_object":"UniProtKB:P21462"}
{"id":"bcb06961-2ec1-445d-94f9-599e668f76b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92941","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:0cf9ce3e-a76d-4690-8399-3cb3381f0f7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1704","original_object":"UniProtKB:P56718"}
{"id":"217e3c59-d9a2-4888-88b7-e93194c76b20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9816339","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:53de33c4-2617-4c33-9ca9-e9efe1a2bff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1361","original_object":"UniProtKB:P49286"}
{"id":"61a32ac1-aafd-4818-8255-507c71ec846e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:2900","sources":[{"id":"urn:uuid:b607867c-373c-49e0-b82f-d2058ed338a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4231","original_object":"UniProtKB:Q16099"}
{"id":"05fb21ed-5ca6-42de-9229-0c8a92fe7a74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104020","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:7e21ced2-b20d-424a-8193-2d88f200c338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:280","original_object":"UniProtKB:P32305"}
{"id":"b18261cb-c52e-4197-972d-b484779658a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9A549FB00R","predicate":"biolink:affects","object":"NCBIGene:58959","sources":[{"id":"urn:uuid:a057ead6-b8c2-4dca-8cf4-ce2956a68b46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3495","original_object":"UniProtKB:P35353"}
{"id":"329be824-5e41-48dc-9c44-cfa4f73e519a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9933831","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:1ab0706e-6b11-4e9c-9106-689080f93f4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1924","original_object":"UniProtKB:P43115"}
{"id":"4f14358c-281a-4d5b-a430-823c0755973f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:c5c92255-f1c6-462f-9730-dec9cf2b4c7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:Q00534"}
{"id":"5ad4151d-f46a-46f9-8873-cc4a7a21d833","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321164","predicate":"biolink:affects","object":"NCBIGene:4968","sources":[{"id":"urn:uuid:81ce48ab-36f2-4739-83ef-481c5f34345b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10184","original_object":"UniProtKB:O15527"}
{"id":"a79ebcb9-8598-4f98-a875-db259dbf968c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66575082","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:dee082ef-6168-4ba2-9b8c-713623cc56b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8698","original_object":"UniProtKB:P56817"}
{"id":"09d9d47b-f03c-4d2a-b895-e0db17dba07a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138743","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:e735ae36-e8ff-4146-a35d-f745c2f61904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1941","original_object":"UniProtKB:P43115"}
{"id":"62c393f0-1521-407e-b738-d492478f1f26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:37bf8bfc-62a8-445a-8801-4a0d7c516568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:P56479"}
{"id":"21c91cb6-3f95-40a3-aab2-87f44aef289f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:ab9cf223-9289-484a-8c47-1a2098c66f62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:Q16322"}
{"id":"0244712b-b6c1-43eb-9a66-649b3a9d61a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92848","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:ed7c752f-af15-4c72-9808-3da6aae4a5f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3286","original_object":"UniProtKB:P30542"}
{"id":"8ada2313-3c4c-4f90-aad0-6b0f45f0841a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CXA4I8AH6A","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:069a0147-fd8c-4ffb-8159-e3c5de45001c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11304","original_object":"UniProtKB:P23458"}
{"id":"7f26dc77-8029-464c-abf9-e859cec1f392","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:77461013","predicate":"biolink:affects","object":"NCBIGene:7099","sources":[{"id":"urn:uuid:d6978e6e-af8a-4ac3-b4cf-2574826c2799","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9137","original_object":"UniProtKB:O00206"}
{"id":"e646477a-fcb6-4d56-9606-c626ed866f20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890319","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:4c48597a-15d8-4c99-8e22-da076542871e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2659","original_object":"UniProtKB:P37231"}
{"id":"e9e6e2da-b3bd-485d-a118-00bc32dfcd6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11071684","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:f1b10db9-e8a2-41d8-b78b-dc406ac26dd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3111","original_object":"UniProtKB:P37268"}
{"id":"8e605ca3-9b68-4166-be5c-b02aa0f25452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:da10c13b-062f-41eb-9e31-555bd55c8c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P08908"}
{"id":"18042e96-81d8-4987-9cfc-9b7f4fac2f48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:e91de6b7-57ae-4ef1-bf20-8d2770bd9fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:532","original_object":"UniProtKB:P13945"}
{"id":"52e35a9d-f69a-4681-8f5a-a52a90bbdd72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92015","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:4dbb4565-bee3-436d-ae6d-bcc419d4d56f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8094","original_object":"UniProtKB:P09874"}
{"id":"8332502f-8ca3-4c85-a4aa-28120a394fa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233090","predicate":"biolink:affects","object":"NCBIGene:11254","sources":[{"id":"urn:uuid:4410c747-565c-472b-82f2-fb590d9bd3cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4693","original_object":"UniProtKB:Q9UN76"}
{"id":"4ff786e5-1df2-46a2-8d0f-307ee1704af4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EOB0N7BOY4","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:f6d8ceeb-83e4-426e-a28d-2ad13ce8e059","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13215","original_object":"UniProtKB:Q9P1W9"}
{"id":"779b9011-78d2-4a81-a4d3-fdb642d31b0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53316647","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:57ae39a3-9c7e-40c6-bf96-fa2d09e4b5de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:455","original_object":"UniProtKB:P29274"}
{"id":"af2762cf-16ff-4369-bab9-930c4bc66994","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121881","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:222603f5-0918-459f-91b9-50d8a27fbc82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:256","original_object":"UniProtKB:Q13639"}
{"id":"7da77eb7-85ff-42d0-95e8-9b23d38de970","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12417","predicate":"biolink:affects","object":"NCBIGene:2160","sources":[{"id":"urn:uuid:93cc1a1e-396a-42ee-b16e-5a6d79257492","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12417","original_object":"UniProtKB:P03951"}
{"id":"96197810-5673-4554-b190-d772b7d250d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72737723","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:81183f76-b689-42cd-81fa-05b9a911d213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8440","original_object":"UniProtKB:P21917"}
{"id":"33f0cad3-69f4-42d8-9010-7677890c57b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:2efd0687-a2ce-4e05-8412-f855c4dd9c22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P05771"}
{"id":"b3b0041b-672e-48bb-b53c-d34cddd9e121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91429","predicate":"biolink:affects","object":"NCBIGene:51305","sources":[{"id":"urn:uuid:9e63d1c8-899f-470b-83ba-fe1564776de4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10069","original_object":"UniProtKB:Q9NPC2"}
{"id":"3ea62f62-dc0b-42fa-9245-064cdeef3cdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9958026","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:e765e725-3a5c-4430-b81e-5f3d25745afa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3468","original_object":"UniProtKB:P25962"}
{"id":"b6e017a5-fde6-403c-af22-24fb7fc56a1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1M7NI1A92L","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:7aa0b642-bcbc-487c-b714-0fc2aef4d52f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4095","original_object":"UniProtKB:P31644"}
{"id":"4ce81326-1528-4442-9a9e-918496fba515","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:27CN8PNO4K","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:49129fe6-165d-470a-b962-0034107c3a40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8431","original_object":"UniProtKB:P34969"}
{"id":"aa246fc0-de99-4d76-b8eb-0a4855820e7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:146245","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:e22d746f-2569-4e92-ac24-0a890220e833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:751","original_object":"UniProtKB:P34972"}
{"id":"2af75665-3507-42b7-bf73-37d8bed452b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2914","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:f7086860-ba64-4250-85f6-556a574c5a29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9537","original_object":"UniProtKB:P02708"}
{"id":"3f75c24a-7099-49a5-948b-766bc6f75786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:6f364d55-d13c-4549-8c9f-f546537084a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P41595"}
{"id":"707e5ef2-9887-4a2e-9112-f4c0b7728233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9827317","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:2af0dbe7-3c5c-4478-a331-a5d03d50cc98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11536","original_object":"UniProtKB:P35375"}
{"id":"0d75b176-4cde-41b9-a50b-a68e266fbc4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:391960","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:83a00721-3a1d-453f-9485-28afd39319e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:321","original_object":"UniProtKB:P11229"}
{"id":"9dca8dd8-38e8-4db3-b4e6-af7acec24028","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:47125e00-2273-4e67-bc7c-b8c24d0e8b6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:O08726"}
{"id":"50e53c6b-182b-46c4-a8ca-0a7f46e09a9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233005","predicate":"biolink:affects","object":"NCBIGene:12748","sources":[{"id":"urn:uuid:2e5183d1-53ad-40d3-8ea7-769d995a072c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5942","original_object":"UniProtKB:O35491"}
{"id":"3da7169c-5af8-4c6a-8e25-3110cb248681","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZFY1ZBQ8AV","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:67b04d47-8c0e-4eb4-8c5d-23679ef03561","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12955","original_object":"UniProtKB:P33535"}
{"id":"026e0c18-1491-4cc7-aa94-070a624918d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Z28M5SX0X","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:4a31b6d9-7492-4188-8423-1317e9440b47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10627","original_object":"UniProtKB:P42338"}
{"id":"94b99015-2d0c-414f-baae-9b08e3373306","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2547","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:cc30cfe0-2148-40cc-a38c-a1599f07dd5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2547","original_object":"UniProtKB:P22001"}
{"id":"d233376b-50c1-4460-953e-bc08ff129837","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25126427","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:b184a770-367d-4508-81b6-8a3a6076f8ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9437","original_object":"UniProtKB:Q9UKP6"}
{"id":"17c02879-398e-494a-b708-a3e677859c77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P909HKP24","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:f4a51c67-0452-4609-ba12-dc9ec7638a54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1216","original_object":"UniProtKB:Q9QYN8"}
{"id":"a1a894fe-08df-4c62-bc44-12772470373f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164437","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:9f1a85dc-fc2e-45a9-a211-ddf5ae8385bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:373","original_object":"UniProtKB:P29274"}
{"id":"614c2dd7-ba50-4a44-8e99-f87c81c68ddc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:1821b302-115c-4c42-a14b-df9f09c61604","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P14416"}
{"id":"2a33694f-486c-4caf-8fb0-356238ad331e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15953802","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:1dd79d55-0c75-48b0-ab75-11a76f74f4e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4125","original_object":"UniProtKB:P56373"}
{"id":"3065ae0b-c122-4d3f-9b59-d18321efb4a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23986047","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:cfba4da9-dab2-4aa5-802f-1a57fa7ca44c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1973","original_object":"UniProtKB:P21731"}
{"id":"f58b448d-8055-4100-951f-1c126d74c505","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54585928","predicate":"biolink:affects","object":"NCBIGene:11096","sources":[{"id":"urn:uuid:b2a46dbc-4acf-4811-b0bf-53fcd7213d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8553","original_object":"UniProtKB:Q9UNA0"}
{"id":"25225a59-d598-41fb-b9d1-093020b0f304","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WCA5SCC429","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:9983d8c6-942f-410a-94aa-52b087e4e9cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3499","original_object":"UniProtKB:P34998"}
{"id":"06ee7eb9-50d5-4354-9fc0-b3884e8c39b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27791","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:bf8e03b3-08bb-4547-8631-b45d5e8e81d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1736","original_object":"UniProtKB:P41231"}
{"id":"bcddddba-a396-4355-9808-ef14e89bcc29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91409","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:e12843ee-cdd1-4dca-9039-2881c4fef6d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7953","original_object":"UniProtKB:P30530"}
{"id":"830ba7ac-5e32-4e90-ada5-ca206a071f43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1522","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:1e2d9833-0ce4-4a13-8f67-e74801927fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1522","original_object":"UniProtKB:P49146"}
{"id":"54265d9e-1110-443d-a0c1-f7ca2b5d3938","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:7a24f52a-28cc-49c8-b103-01f0869c2efc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4156","original_object":"UniProtKB:P14867"}
{"id":"a21473c3-3723-4609-9ec4-9716cede8761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76849261","predicate":"biolink:affects","object":"NCBIGene:24410","sources":[{"id":"urn:uuid:e55b8ec1-2d26-4193-9d72-9af8e06cbc22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7843","original_object":"UniProtKB:Q00960"}
{"id":"df69e82e-320a-437f-b127-7de316391bd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56968001","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:c7e8901d-ec68-4dc0-8e48-7877956ea78e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8884","original_object":"UniProtKB:O00763"}
{"id":"de9a49d6-87e1-41c6-8860-5c14aa8d0995","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:8ee2f99f-cd20-4f7f-9df8-5430e60495c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:P23458"}
{"id":"3b1e48fa-ee38-436a-a07b-c3a54725c413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:2b583ee0-6144-429e-ae76-3d7c19fb8f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P28566"}
{"id":"1c116b7b-b4f6-4c9b-85ee-565174565eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623351","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:81f29d02-4dfc-4da7-b2de-edc1ba02c287","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2974","original_object":"UniProtKB:P51639"}
{"id":"da6ea652-40f2-4889-b50c-79b0e9f66e81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70934541","predicate":"biolink:affects","object":"NCBIGene:10298","sources":[{"id":"urn:uuid:c1bd20aa-0107-4e79-a476-b365ac5e7d06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8939","original_object":"UniProtKB:O96013"}
{"id":"c9f00224-4b3c-480e-9fed-cd1df93f83d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9614","predicate":"biolink:affects","object":"NCBIGene:14527","sources":[{"id":"urn:uuid:a0034b09-178a-4e05-b2ba-5b0af322abf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9614","original_object":"UniProtKB:Q61606"}
{"id":"ad183496-cd01-4103-9274-6839e433f65d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15335","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:46101d65-1d96-4b2c-9fca-a0350997aec8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13776","original_object":"UniProtKB:P21397"}
{"id":"05888aa1-3761-4e74-95ac-adca532aa9a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:8087fae9-2db6-4e5e-a780-a98c38818c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P08912"}
{"id":"98a803ed-0e94-4cb7-9b3c-ce7f2e75b492","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155590998","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:7686028d-46a8-406e-a1ba-270099cf0d8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12615","original_object":"UniProtKB:Q15910"}
{"id":"8d06f02c-fb8c-4377-9739-8f040b6b7374","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13920","predicate":"biolink:affects","object":"NCBIGene:8824","sources":[{"id":"urn:uuid:72d8711f-0134-416e-ad64-7e1b7aee3115","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13920","original_object":"UniProtKB:O00748"}
{"id":"8af411fc-5278-4235-9c9a-0d2dad6fc097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6163","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:07312efe-2dcc-4b46-b2f4-06b9cf83348a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6163","original_object":"UniProtKB:P28336"}
{"id":"473cd285-be08-4d43-90aa-c239018dd71a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189867","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:a738bb7a-4d58-465c-9ef5-134df0ff0920","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9354","original_object":"UniProtKB:Q08345"}
{"id":"a6613fb7-d123-4c85-ae98-1b177d728d01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93432","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:f8a469f5-a0d1-4bdd-a6e5-168992bdcbb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8584","original_object":"UniProtKB:P08173"}
{"id":"f58d96fa-659f-4ad9-8056-83056bfaaa8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3070","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:10a1d4b7-4107-4c3d-9898-c2609699ebdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5151","original_object":"UniProtKB:P09960"}
{"id":"a74200db-adf5-44dd-bd1e-7901039a7571","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:e108442d-ed54-445e-8134-77010c31789b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P35367"}
{"id":"9e2b023f-b0fb-4df1-b08a-a40215b43fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70689167","predicate":"biolink:affects","object":"NCBIGene:6768","sources":[{"id":"urn:uuid:0ca08645-5273-47d3-8987-72ed35f17e1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8624","original_object":"UniProtKB:Q9Y5Y6"}
{"id":"d6f08e54-0b06-4c21-a51b-2ea9364ff191","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K16AIQ8CTM","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:7d5ddb90-634c-41c8-938f-b41aac2d5044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5046","original_object":"UniProtKB:P04626"}
{"id":"62e29830-6680-47c8-bed4-826b100507d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:91D8378G2V","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:65ecf3de-77df-4eb1-ab99-bc053c34ce6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10647","original_object":"UniProtKB:P17752"}
{"id":"81e7794e-fffa-4f6f-a93f-552d6771338a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46226500","predicate":"biolink:affects","object":"NCBIGene:1138","sources":[{"id":"urn:uuid:4920a732-14ce-44cc-92d6-f6bfd4a0924a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4011","original_object":"UniProtKB:P30532"}
{"id":"2f39088d-fcfc-448c-93cd-65439c0d461d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156775102","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:6904fc9d-1a28-4529-98bc-cc766d1f6d5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12143","original_object":"UniProtKB:P25440"}
{"id":"069da5e8-d039-450f-9c68-b8b694c62593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RE9JUR6NT4","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:88a92267-5418-412f-a440-582a1e0eeecf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9783","original_object":"UniProtKB:Q9GZU1"}
{"id":"078c4cb6-720f-4e46-ac6b-6cfa95892e34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66903","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:c42b6c3d-ce74-4001-8ab8-87e19d581182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6975","original_object":"UniProtKB:Q99835"}
{"id":"64ba3e71-b1b8-4152-83f9-3a91b784ab2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5707","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:553bf0a8-7224-40f6-8d4a-079b3fbe5e72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:323","original_object":"UniProtKB:P08172"}
{"id":"e3c857cd-44df-4dab-a4dc-97c72882a8c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94355","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:c4ee5d15-d268-4a1f-ba64-aa481bec3362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8311","original_object":"UniProtKB:P15538"}
{"id":"9da5dd43-2eff-408c-b84a-2c761f0ec16a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229225","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:37fefc5b-a93f-4cc5-9960-b29ec2991635","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12335","original_object":"UniProtKB:P13866"}
{"id":"34d3ea07-deb0-4863-908e-7cc1480af1bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:522609","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:f45bd3e1-6f55-4b2e-985b-b4b9b118efcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:282","original_object":"UniProtKB:P32305"}
{"id":"f8fb4cfd-32db-4f9e-9881-be690e4e922b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118556943","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:8a048651-6bd9-46b7-ad0a-34fb2f57e577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10365","original_object":"UniProtKB:P48736"}
{"id":"79a5746c-c658-4821-93b9-bed5b2480292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192802","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:717ab8cb-15b7-42cf-9a0a-31c1e0b0cfe0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8225","original_object":"UniProtKB:P14902"}
{"id":"b0d0beea-ce55-4d1d-9202-6cd28c889de2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LQ52UF48A","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:d785175e-1957-4880-872f-e759cc86566e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5945","original_object":"UniProtKB:Q00535"}
{"id":"d5b20bb0-636f-48a3-b03a-55f1efa4f89c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2814","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:e76ccf00-d08f-4bbf-b9e7-b37fb7413afd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:296","original_object":"UniProtKB:P08912"}
{"id":"bf6cb9dd-32e6-44d9-b684-121f3665f7c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53238181","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:f9652af5-4fbf-4d10-ac1e-80788947b6c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7780","original_object":"UniProtKB:P49286"}
{"id":"1b81bd4b-7015-41c7-a963-df3cfd6274c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6878","predicate":"biolink:affects","object":"NCBIGene:2346","sources":[{"id":"urn:uuid:ed48f7e0-b0f0-482d-8f61-ea47da0f9589","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6878","original_object":"UniProtKB:Q04609"}
{"id":"5eb3fa16-2091-4961-b9b7-35b03b5c87ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45073499","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:5e3f21fb-7876-4803-8ca9-a60b9f5bb46a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5525","original_object":"UniProtKB:Q14330"}
{"id":"1366c381-799a-420b-b5b0-348c5eacdfb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2825","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:3d8e5310-77ec-4ced-a493-034bad8f3cff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12438","original_object":"UniProtKB:P59538"}
{"id":"d1be8d75-d6e6-4a14-b2ce-6a0eaf442b86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50991498","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:82870b5f-fa64-48a1-a243-c5a645445d9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6540","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"03cb36dd-16e2-4cfb-a90a-2d65bde4f7c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4046493","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:a94ace9f-8085-4bb7-97ff-e78d4d6cedc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3280","original_object":"UniProtKB:P0DMS8"}
{"id":"29bfb4b7-52bd-44d8-ba75-15bb69a0bfd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6431","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4339c9e3-6cff-49e1-8804-7550f5c4128b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7209","original_object":"UniProtKB:P35372"}
{"id":"f8e91b22-9b3b-4d22-97ef-329ccf821dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368937","predicate":"biolink:affects","object":"NCBIGene:197259","sources":[{"id":"urn:uuid:07d33d49-eeab-4a9a-8d23-d2c748b0771e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12194","original_object":"UniProtKB:Q8NB16"}
{"id":"dc71bed3-3201-4041-927f-a3eb691f0545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LA5AQ5R6QS","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:f9939654-f59a-4d59-aa68-d51bf868d6b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8433","original_object":"UniProtKB:P34969"}
{"id":"24b0ac45-cb74-4803-a127-df06ab89f07c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:57165","sources":[{"id":"urn:uuid:7e905f11-ebbf-49f1-8f78-6b019cd93a12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q5T442"}
{"id":"23a9f9ee-cf09-45c9-8e29-f587c0d5d2f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W34UO2M4T6","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:21bd9b10-cd3f-474a-88b4-89fc241d7582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5661","original_object":"UniProtKB:P10721"}
{"id":"16ebebff-5ba9-4e61-b30f-6acbf2a7bc25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44560455","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:9158031a-6396-4647-a0d8-af8f1fc81311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11405","original_object":"UniProtKB:P17752"}
{"id":"07502568-1bca-4da8-9cb5-fd5834a92256","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91666633","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:9573b6e5-3237-494a-83b3-c6f856212ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10003","original_object":"UniProtKB:Q15858"}
{"id":"6ca9a8ae-4d1c-4ef1-b86c-330b6766539c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91931649","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:050813fe-e01a-4047-bbb2-2a964d2f6cfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1531","original_object":"UniProtKB:Q63447"}
{"id":"1e392ba9-f55e-4c06-aee3-2ab2dd4204bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125525","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:b331a007-0398-4874-af56-b20c36cd2724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1238","original_object":"UniProtKB:Q9H3N8"}
{"id":"20b47b6c-c97e-438c-8965-e420f4338c6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90695","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:a9d3087a-aadd-4e38-8d07-7b5d3bae88b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5273","original_object":"UniProtKB:P45983"}
{"id":"eea51ccf-3c02-483f-9d08-55b93d438a07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3713","predicate":"biolink:affects","object":"NCBIGene:229214","sources":[{"id":"urn:uuid:15ea718b-b43a-470c-ad1f-6f7a8a509a34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3713","original_object":"UniProtKB:P83861"}
{"id":"3c323015-68f3-4873-a0fe-3b799048b103","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111173","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:63400062-6252-4f48-93d7-773336eac79d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5258","original_object":"UniProtKB:Q08499"}
{"id":"419aed31-053f-4b84-a3a2-b0cf51f80f8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:684516","sources":[{"id":"urn:uuid:8ad165c2-0072-43b0-b45d-09caa6cde126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q63734"}
{"id":"0dc6a333-9eda-4bf9-8d1e-ac2a3b652329","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2546","predicate":"biolink:affects","object":"NCBIGene:29731","sources":[{"id":"urn:uuid:326d839f-5e93-4177-8088-0a290a12705c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2546","original_object":"UniProtKB:P15384"}
{"id":"2833a4d5-2f81-449c-9a89-81fb7e1f6ca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131167","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:8b62351e-65c9-4906-a319-501bb886ee9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7835","original_object":"UniProtKB:Q16539"}
{"id":"40a0603d-adc6-402b-bdc3-ffbe7d574fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92537","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:09b1c3c9-4578-4a42-b1f0-a1e8b7f244d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:28","original_object":"UniProtKB:P28222"}
{"id":"731839e5-2d25-4bbe-9929-c547dcc499b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4014","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:8469a67c-d2e8-42d2-b0ad-bb20ebbbe4ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4014","original_object":"UniProtKB:Q969F8"}
{"id":"4e3455d4-1b44-4aac-ac33-f5bcc197249b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34310","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:533991b1-8c5a-449b-8d60-01b57dde0530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2750","original_object":"UniProtKB:P55055"}
{"id":"39cbe695-c31b-479c-bb10-a33cf7b53a86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63637","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:54dd3cf2-fcae-4f24-b37f-ddec6a676215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5893","original_object":"UniProtKB:P04049"}
{"id":"e7345ece-c54b-4553-9ea7-2d9a22336b5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2048","sources":[{"id":"urn:uuid:184407ad-3f45-4a9f-886c-f1dc0786deb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P29323"}
{"id":"4aa6fc5a-137b-46d2-b0cd-e7d2a40edea0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36706","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:1a34e6f8-cdcc-4ccd-b91d-99ff9b653dc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5051","original_object":"UniProtKB:Q9NR97"}
{"id":"fbf8a236-e447-4cac-98db-ad426b8b2cb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:da784fa5-6bfa-4dd7-bab4-1254ed73e06d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P06239"}
{"id":"f97c38d2-c04a-412f-b209-a950e7877c94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10449757","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4fa123e7-3596-47f9-8a54-17059703c625","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:190","original_object":"UniProtKB:P28223"}
{"id":"ee958e52-083a-4457-a797-ab370cae065a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47943","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:1cd29a8e-f6da-481b-bd54-23b504226861","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4133","original_object":"UniProtKB:P42262"}
{"id":"415f0c9e-aba0-41cb-8e5e-919fcf8b9c74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71300326","predicate":"biolink:affects","object":"NCBIGene:80854","sources":[{"id":"urn:uuid:12d6163e-23c4-4049-95d5-1dbf0265f8ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8235","original_object":"UniProtKB:Q8WTS6"}
{"id":"6ea33470-cfd3-43f4-8267-f2a3b0afcca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82813","predicate":"biolink:affects","object":"NCBIGene:1261","sources":[{"id":"urn:uuid:5c10bab5-03ab-4a39-acea-ff72c5dee4c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2349","original_object":"UniProtKB:Q16281"}
{"id":"c906213c-8330-4d09-a481-56f75c6711e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13330","predicate":"biolink:affects","object":"NCBIGene:6622","sources":[{"id":"urn:uuid:98968a5b-ecfe-4563-8934-dbad54b7f912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13330","original_object":"UniProtKB:P37840"}
{"id":"270735d6-abb6-43cd-b139-454a62a05c64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133021","predicate":"biolink:affects","object":"NCBIGene:599","sources":[{"id":"urn:uuid:b2f2bb22-c1c5-4b07-8669-83cee18713c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8318","original_object":"UniProtKB:Q92843"}
{"id":"7c4bbe58-2d86-47f3-8b06-7fa4b667c58e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73504719","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:2e386ce8-4d8f-41cf-81d7-d99c64fa0c97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12391","original_object":"UniProtKB:P08581"}
{"id":"0268ec28-db61-4ce7-a1bb-919653d5bde0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49858117","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:bd0877ca-ee51-4d78-bce0-ebf244594579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6223","original_object":"UniProtKB:Q14416"}
{"id":"a0be0fb6-b136-44b2-8105-29327e106391","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:6096","sources":[{"id":"urn:uuid:df6a48a0-a37b-44b8-8064-5d028be9bac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:Q92753"}
{"id":"dcd957c1-9f17-46c5-b927-07e7a3dd2da4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:94055UOQ3Y","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:863fcba1-7e42-4081-8ac5-06ff7737b8a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3854","original_object":"UniProtKB:P30968"}
{"id":"6274ee80-d4e4-40c8-8307-6cbbee4ea4b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:cf68944a-ca75-4606-8566-7e13a465c184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:O00222"}
{"id":"395f2939-ac0b-4841-9c50-1e70eeb1d3b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131351","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:d6b908fa-258c-4716-8b73-dafa0aef137d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:384","original_object":"UniProtKB:P30542"}
{"id":"72ba02fc-dcf0-47de-9710-b2c4595e610f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2325","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:9af49133-c873-4822-b681-294b1a032858","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2325","original_object":"UniProtKB:Q9UGI6"}
{"id":"f21f743a-35e3-4e22-973a-1653ff37c0fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3897","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:d1669294-114b-49a0-bf5d-a7e5ed38ab35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3897","original_object":"UniProtKB:Q62805"}
{"id":"fdf6f430-de2d-417b-a608-da0f563eb94f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:ea0a4a4f-f59f-4dea-a2d3-b42c78b5b2a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P08908"}
{"id":"af61385c-fbdf-4a2f-914c-02a0219bfbfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:1969","sources":[{"id":"urn:uuid:9a9c97b5-5c0e-492e-9dfa-57de0dc8ecdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:P29317"}
{"id":"bd8061bc-2220-4c85-84a8-0e2cb028f421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1989","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:dd9e435b-b799-4171-8b97-958b37e0b45d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1989","original_object":"UniProtKB:Q9HBX9"}
{"id":"d6781fc5-1ac8-43e9-8eab-8cbaea68aab6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91549","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:6f347759-1936-428f-a086-9c64b99a1b5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8","original_object":"UniProtKB:P08908"}
{"id":"aa5d4e12-ccf3-44a0-8c90-6d15c847ed64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75342","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:ffad751a-111d-4fbe-9adf-362fedd47078","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5756","original_object":"UniProtKB:Q8TDV5"}
{"id":"e7143b7f-d126-419b-b2ab-727129ce0a73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9CD894KUMJ","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:dcb5ff7e-b35e-479f-84d8-a7d97d63631d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5816","original_object":"UniProtKB:Q62928"}
{"id":"6d632768-0460-4520-9fc8-4bba6aa2b6fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:22067","sources":[{"id":"urn:uuid:2da466d3-6815-4dc2-a047-02ea8d82ecf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9QX29"}
{"id":"d36738c4-687a-413d-a528-317f721e7efc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135938","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:cdd0ac59-542a-4bb3-8bbc-afb2996913ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7542","original_object":"UniProtKB:P03372"}
{"id":"601a033e-164b-4edf-baf1-848b9181f5f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:63D4RUV1GN","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:4418b357-5e7b-465d-80da-1750d6a3ab66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10578","original_object":"UniProtKB:P42336"}
{"id":"4a470eb9-1825-479c-8c89-95294e501b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:96cd478b-a33c-45a1-b798-4e539a1f88c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:O08726"}
{"id":"1b8f2617-ef05-4550-b9fd-40c77f9cb294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91451","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:3cc77bfb-1fb3-4008-8d0f-ad3dec1273e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5674","original_object":"UniProtKB:P15056"}
{"id":"c984fafe-865d-4713-ab43-9666dafbd1a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755000","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:50abd5fa-73ff-409c-8dde-9acb29ece3eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1230","original_object":"UniProtKB:P25102"}
{"id":"82d9eaaf-8d5a-43a9-9b2e-8c86321e8724","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10255622","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:82f79222-419b-45ce-b8ed-3499805b61d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:791","original_object":"UniProtKB:P51677"}
{"id":"e2206c46-905f-4c49-bdf0-f8d42bded286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2544","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:2c5b24db-d88a-4bd3-998f-0fbe4ad0c663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2544","original_object":"UniProtKB:P16388"}
{"id":"d489a284-9d8b-44b3-af64-02e5028b15db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17268","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:48a26c08-b14f-40ca-8caf-8c6337d18079","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2094","original_object":"UniProtKB:P25103"}
{"id":"a3b62533-7627-4cf9-9f48-f9763ce3098c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312112","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:41f2f010-c7ec-4395-afc0-736560882a65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:415","original_object":"UniProtKB:P0DMS8"}
{"id":"7ca9ccef-dda3-45c3-b5e1-41965df46121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:532def8d-aa4b-43c5-9208-e11acb4e0c00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q13547"}
{"id":"a6364ff2-9dd7-40cb-857a-c052d3cbdabe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KIB8V5UR7D","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:47d1dca0-4b13-461a-ac33-3237274275d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9774","original_object":"UniProtKB:Q7Z2W7"}
{"id":"a55ce836-7ebe-4e87-8c44-df41040ad188","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2027","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:3a4689ec-e943-445c-be20-e4bd2b93cd60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2027","original_object":"UniProtKB:P31391"}
{"id":"518d6155-f0c9-432a-add7-9db2e7ffcea4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:85ff3664-d61b-494d-9109-31fdde50d2c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:Q02763"}
{"id":"50d50f0d-5790-40c4-b18a-f822e7308f3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11476","predicate":"biolink:affects","object":"NCBIGene:3737","sources":[{"id":"urn:uuid:f60a130c-1b39-4163-9659-379f2a2b9e1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11476","original_object":"UniProtKB:P16389"}
{"id":"93da7495-1af6-4ea8-abe9-e05fe11d1619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136678","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:17195f1d-0da5-414f-b8eb-ca58c4dca91e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:8899","original_object":"UniProtKB:Q9HCF6"}
{"id":"3e6a7bb6-9c22-41fa-81e6-c29c3d885fcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:209090","predicate":"biolink:affects","object":"NCBIGene:1510","sources":[{"id":"urn:uuid:5c908859-966c-4f38-a2b6-6f0e240beaf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8674","original_object":"UniProtKB:P14091"}
{"id":"98f30f25-77bf-423f-84bb-fc153b61a05d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136003","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:92893013-5d38-4f9b-af66-3f3c95a0a98c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1605","original_object":"UniProtKB:P35372"}
{"id":"647377f8-b28a-4831-a597-2925270bd297","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71158523","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:0bba5b9a-fb6a-46d4-b70c-cd8cd53dec65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10161","original_object":"UniProtKB:Q92736"}
{"id":"c45dcc07-72ab-4e1b-a8bb-786ad5be5628","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177520","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:53c4fdac-3f8c-4e6a-8e14-848c681052e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6482","original_object":"UniProtKB:P45452"}
{"id":"2349406c-380c-4624-a550-1ddec380467d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:d8e0f8ad-464b-42fd-b336-0ac50ccaef48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P36888"}
{"id":"050bcc3f-398c-4e7a-831d-36db5b46bec9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145966622","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:5220ae75-9389-48ff-8c12-f0c0582edbdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12324","original_object":"UniProtKB:P97612"}
{"id":"5c6a2904-9279-4ee2-845a-9672c0e3bb20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MFI2XG2PVK","predicate":"biolink:affects","object":"NCBIGene:8639","sources":[{"id":"urn:uuid:7d050a4f-dede-482c-a856-122e3f922532","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9346","original_object":"UniProtKB:Q16853"}
{"id":"47806c6f-ce29-4a3e-abbd-0bae616da134","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S4M959U2IJ","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:dbe6f9a5-ba72-4a9c-aa7a-860bdb5c14f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12252","original_object":"UniProtKB:P07766"}
{"id":"0e846f3e-d9d3-4b01-a923-aeed95e1daf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6K6L7E3F1L","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:caf50d4f-b378-4958-aad5-5fb34d00cbaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9540","original_object":"UniProtKB:P56373"}
{"id":"3902dd79-cd8b-4338-a80f-5c383451163d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U3T5W003VP","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:8ab7e322-0a84-4431-958d-9818881ebf01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11730","original_object":"UniProtKB:P12931"}
{"id":"754f67eb-7945-4f0e-a5b6-dd8c9c2a53e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2222","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:d2734b91-1da1-4273-ad0f-2f342ecd6912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2222","original_object":"UniProtKB:P37288"}
{"id":"1c9339fa-3fa4-43d8-8a64-236f76d5afe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127948","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:652e33e6-9a33-4ff4-97e3-bc981ebc427c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:884","original_object":"UniProtKB:P30551"}
{"id":"18e07481-e3cb-4ba2-b9da-75a0ddf8e255","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27965","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:15ea21e9-80b1-4b07-9239-0dcb7b114971","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8981","original_object":"UniProtKB:Q9H3N8"}
{"id":"26e2d0fd-0b0f-4c6e-b1f5-cf35cbd13786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:3743","sources":[{"id":"urn:uuid:99a6727f-ef06-47a8-91bf-9524a28e829e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q96RP8"}
{"id":"fb77dcd8-7ff8-4734-8256-e0fad74492a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:fb6fe117-3eb6-464b-8672-5c89a36c42b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:Q9UQB9"}
{"id":"7e98c16f-d0c5-4552-99c3-c128528d45dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311023","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:bdd6998c-7e8a-4999-9bcc-1dad8a998c4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1485","original_object":"UniProtKB:P25929"}
{"id":"ca5f0850-3a72-49cc-8352-f0651fbcc4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7730","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:fe3bacc5-72f5-4fb3-a97c-ab989d8923d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7730","original_object":"UniProtKB:Q8NBP7"}
{"id":"0cafbc52-2d3b-4440-a144-6a581fc22d08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587563","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:55d7cb95-b0ee-4dd5-bb8b-e38315e0fd90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11662","original_object":"UniProtKB:P11802"}
{"id":"50eb86ca-e111-4018-a0cd-09e9949fbcdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KU59Z0XVL4","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:309938d6-d592-4abf-9f0e-d21a20c02c23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3179","original_object":"UniProtKB:P14324"}
{"id":"9181ee83-c079-425f-b160-3ab93b1e204a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90724","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:058bcc6e-6dcb-4b36-afd6-ff8fbe95ce36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3317","original_object":"UniProtKB:Q14330"}
{"id":"de5d3c9b-9de0-4c00-b9ca-c96ce873e8b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25077385","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:199b0989-0f76-4610-82b1-399fafd63710","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:607","original_object":"UniProtKB:P61073"}
{"id":"c30841a3-f18e-4262-929e-0b74ad8582ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:410a63ea-2474-4bea-baca-7dcf42deba21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4192","original_object":"UniProtKB:P31644"}
{"id":"6be80d11-5658-42e9-a7ff-cd84a7ee715f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:e57b4d73-147f-4e45-b141-29724e1f0fd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28335"}
{"id":"8155796b-443c-47c0-b09f-aef433b467cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SRV0JCF9LI","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:e3b31f1f-c3ad-45e9-b97e-769d99979c19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5685","original_object":"UniProtKB:Q16620"}
{"id":"f264e468-dea7-4e4f-8458-bceb897c78dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2697","sources":[{"id":"urn:uuid:f52cbed5-90ba-4c5c-b627-d36689aae63c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P17302"}
{"id":"20cf2cf8-33f3-4036-9f10-797cd82e6423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11641076","predicate":"biolink:affects","object":"NCBIGene:1573","sources":[{"id":"urn:uuid:6b0d283a-387d-4bc5-bb28-2a6d0b06e31f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8832","original_object":"UniProtKB:P51589"}
{"id":"1ce9d38c-8132-4ac9-a261-a517342f08ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:794","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:82812f62-8360-422b-8234-0a8488ad4c15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:794","original_object":"UniProtKB:P51677"}
{"id":"c876dc4e-12aa-4509-bfad-ba9867b5b4ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1992","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:f84825bc-f366-4ad5-9ed5-b318f7e0de4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1992","original_object":"UniProtKB:Q9HBX9"}
{"id":"e36930bf-67de-40e1-8cf7-696490f54208","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91354","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:629815be-b73a-4dc1-9162-ce5bf7d0b01b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8475","original_object":"UniProtKB:P15056"}
{"id":"ee9aabe3-83aa-441e-9329-e86e9ff7e3a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5354004","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:51388f1d-1b60-4368-b7e7-df6d6e05d3fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12963","original_object":"UniProtKB:Q16678"}
{"id":"e4acbcd9-6917-40fb-8b7e-57036e7e8626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:f15806ea-be62-4770-a94a-d5f623fc483d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P18089"}
{"id":"f006e60d-1f65-4288-8cc4-fa94dcf54d1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352892","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:6a2df877-7204-407a-bc0a-a8ab8ad4451f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3082","original_object":"UniProtKB:Q02769"}
{"id":"32e78dc8-83ae-4997-a844-472ce2211a13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2668","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:bd282c81-4dad-4084-94f7-208060ab9fd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6981","original_object":"UniProtKB:Q99571"}
{"id":"4f1a6603-229e-44cc-bad5-6793ec2209cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:613a4c78-ccd2-470a-b19b-9ff35eac65a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P28221"}
{"id":"513dbc95-4b90-40e7-8a12-7781c93dcd8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FB39E94UXK","predicate":"biolink:affects","object":"NCBIGene:7941","sources":[{"id":"urn:uuid:c476d891-f442-4b99-ae78-a6af521b69d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10062","original_object":"UniProtKB:Q13093"}
{"id":"96a98c8c-c77d-433f-a9f9-348867b15472","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44338671","predicate":"biolink:affects","object":"NCBIGene:11330","sources":[{"id":"urn:uuid:be229e27-0995-4281-8ee0-ddd1757df16e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8555","original_object":"UniProtKB:Q99895"}
{"id":"aa7eaafd-7abc-42f8-9b6e-6cc926075ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4315","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:520ffd31-1d33-4f9a-af17-fa2191ecc6f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4315","original_object":"UniProtKB:Q07652"}
{"id":"4c385aa4-7b9f-4c9f-b811-51fc30e6267b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2259","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:b055057f-6507-4513-9236-cf94bff988e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2259","original_object":"UniProtKB:P41587"}
{"id":"219e762d-d236-42d8-b414-2126c03dd956","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:640","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:63dad469-21bc-4577-a52e-a41169cb3da1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:640","original_object":"UniProtKB:P46663"}
{"id":"ce5dba35-7337-408f-b7ab-a3493d01f6d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88822","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:7b7b2dfd-c458-4431-b4a9-a6c8e940662b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12471","original_object":"UniProtKB:P59537"}
{"id":"d95822d7-5551-4a18-8079-d56e510b48d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:60eced6e-9b8d-41ce-9470-fa5274c4b762","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P08588"}
{"id":"eaae01fd-fdb0-4cc1-b27a-2c2df0a465d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4345957","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:953dd477-cb4a-441c-babe-dcf3b9fbf776","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:613","original_object":"UniProtKB:P52500"}
{"id":"5df03b0f-3431-46e6-96e7-071c5dcc94d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9825701","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:94602aa1-cb10-4a4f-b659-db1eec85d3c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8907","original_object":"UniProtKB:Q07869"}
{"id":"2450dcf1-d559-4aa1-a1b8-1ec06b5a782e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1795545","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:102aa926-0489-4202-b73d-daa8c4b7bcb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1414","original_object":"UniProtKB:P70579"}
{"id":"9a86305b-28fd-4bf3-8027-53552d2cb834","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:84f569f1-d57a-43cb-90ca-389a578fc12e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9UL62"}
{"id":"425d3242-8968-4c73-8b29-990c309440fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49871766","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:cadc3a8c-061a-4a66-ae9a-ebc683e57488","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6170","original_object":"UniProtKB:P30550"}
{"id":"9eba20ef-1332-438f-bf3c-95aeba414ac5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DF5M8SYV7J","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:2b57ade3-622b-48e7-999a-b598ca024fb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9679","original_object":"UniProtKB:P51679"}
{"id":"1b088306-5853-4891-83df-dff0a88ab261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:2a6f7098-6d0e-4e98-9b7c-3c7a885b31d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P35462"}
{"id":"85c2c947-bdb1-4f25-8ed6-c4afd4d5f843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91471","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:d9ed010b-9403-4172-9ace-be92ac4cdb0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5672","original_object":"UniProtKB:O95835"}
{"id":"f45205e5-d6b8-4d53-a4ca-07f731c47dcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117902000","predicate":"biolink:affects","object":"NCBIGene:11183","sources":[{"id":"urn:uuid:a6dd4db3-43e6-4251-861d-44a5120e5587","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9964","original_object":"UniProtKB:Q9Y4K4"}
{"id":"deaf3203-63ef-4b75-a7c3-2fdb7b87eca9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:cd8ace5f-296c-492d-93f1-584b0cd9e09a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P28566"}
{"id":"47d03fa7-37ce-4eec-a287-67e7521848fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93752","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:d715cf9c-41d2-4e06-b847-d6e2fbe89af6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7955","original_object":"UniProtKB:P48736"}
{"id":"798a5553-386e-4f54-b0d6-b8e57c6becd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:034df7f9-d7c3-4eb7-8b98-8c53473840d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08172"}
{"id":"c0ccfef2-3911-4105-9a3b-d7b8d802535c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:ed4ebe2d-0836-4d63-94ff-4693908292db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P18825"}
{"id":"9524352b-ce49-4708-b5dc-0930f95b3b0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103932","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:757e3f82-4e56-466d-878b-0dbea9929385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:463","original_object":"UniProtKB:P0DMS8"}
{"id":"30a0a830-be7f-43e1-a835-b87e446aa9f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44815217","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:fbfc0bee-8509-4428-bb0e-d707305d95b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6622","original_object":"UniProtKB:Q9NYA1"}
{"id":"101086a8-5dc8-4413-a702-27ed48cf2086","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871653","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:5fa3b1ee-05a4-46b6-a9e0-405d123b006a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8208","original_object":"UniProtKB:Q9UM73"}
{"id":"49e13ba4-2fa6-449c-8ed1-409c362e3e2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19093029","predicate":"biolink:affects","object":"NCBIGene:1515","sources":[{"id":"urn:uuid:cc767700-dedc-4526-98ea-13ee3fa44612","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8561","original_object":"UniProtKB:O60911"}
{"id":"caf3cc21-f384-48cc-a6ab-740efa733462","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:caff13a0-b2fe-40cd-a573-53659a4ec352","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:Q16832"}
{"id":"dbb89a6d-6541-4044-a57c-95c5a83c2105","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2521","predicate":"biolink:affects","object":"UniProtKB:O54898","sources":[{"id":"urn:uuid:6aa35c07-87a8-4739-baaf-dd93ac899d34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2521","original_object":"UniProtKB:O54898"}
{"id":"ea0e1dda-aa86-4f87-8678-540c9c34c378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OEP8JJ3OZR","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:de7281ee-711d-4dc4-ac13-675efd2d912f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9425","original_object":"UniProtKB:P42336"}
{"id":"969d41c5-9206-42d6-8a78-e04c93f80f71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64045","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:2d8ab2da-b225-4c9a-9686-a5168a357b93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:963","original_object":"UniProtKB:P14416"}
{"id":"453dacd2-0abf-4738-a6ad-6b27d45ee42a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18293","predicate":"biolink:affects","object":"NCBIGene:50839","sources":[{"id":"urn:uuid:ff6cfc75-420b-41da-b850-a80f189c3a1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12431","original_object":"UniProtKB:Q9NYW0"}
{"id":"da57f9ef-6622-4cea-95ea-d70782a15079","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1513","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:66324357-d965-49d3-88c6-1f76134dd75f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1513","original_object":"UniProtKB:P21555"}
{"id":"4b469b1b-6bb1-426e-95f3-a2f3781a1cd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2531","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:acb0e5da-7094-4909-9da3-f8257e02470e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2531","original_object":"UniProtKB:P54282"}
{"id":"81b9989d-99a9-4da2-932f-b81ff40ac6bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122211","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:9d2bc4fb-49fe-4bc1-bd77-fd959c0b9a42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:524","original_object":"UniProtKB:P18089"}
{"id":"31b54cec-9654-488e-ad0a-b864a3726798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131751","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:2fc8980e-bf3d-4485-8d48-eb6dd4249d5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10820","original_object":"UniProtKB:P00374"}
{"id":"b9ed2d9a-6f7c-4e8f-af52-234109298f3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7K28NB895L","predicate":"biolink:affects","object":"NCBIGene:2034","sources":[{"id":"urn:uuid:06f3b666-1463-4433-9a9b-3f1b4182c567","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11251","original_object":"UniProtKB:Q99814"}
{"id":"fb61df74-78f5-4e36-9107-ce96b2cba0e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7760","predicate":"biolink:affects","object":"NCBIGene:3745","sources":[{"id":"urn:uuid:155d830c-61c4-46d4-aeff-427adf3cf9a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7760","original_object":"UniProtKB:Q14721"}
{"id":"3c6d3069-5ecb-4b7b-8524-8934cfceb985","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L33EX3XR0T","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:8395babe-010e-4b85-ab79-9bf8a7fc3475","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9718","original_object":"UniProtKB:P34913"}
{"id":"9346df97-f676-4e52-92ca-bcea4b844863","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4L1AM42NVA","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:a80745ba-671a-4c7a-ba73-d41b7667f0bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7971","original_object":"UniProtKB:P52333"}
{"id":"cf4510f5-f199-41e6-bafa-5076dc93c880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133797","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:55667a18-1f67-4431-9e7a-16d47859836c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2311","original_object":"UniProtKB:P70604"}
{"id":"88d1d085-7091-417f-8d87-bc9611eb6167","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8d73ecbf-1121-4c17-adc5-9183ea0ad86f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P08173"}
{"id":"e0a1c541-29fe-4539-af89-b2321f931b2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NCS2VAH93R","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:a39322d7-baef-4ca0-acf3-ee19bafd5927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8436","original_object":"UniProtKB:P32305"}
{"id":"635ca8fb-e1c7-4167-9376-fde8a401ec62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232556","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:70b1b8f6-773a-433a-95c7-763df6523214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9039","original_object":"UniProtKB:P35968"}
{"id":"b63099d5-dba4-446f-a476-f85bcb9cde8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2211","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:e43cf483-91cb-452d-92cc-d3d157cd81ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2211","original_object":"UniProtKB:P30518"}
{"id":"8b7ba239-b9a2-4dac-9381-24aea0b393f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:b7b666d3-7c40-4c6f-ad7f-2117a767703d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:Q9GZZ6"}
{"id":"d240945a-4ec3-465f-8686-88edd541417e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4324257","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:b862050a-5b41-4530-8dce-91363bcc8a43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4080","original_object":"UniProtKB:O15399"}
{"id":"25166da7-fa5e-48e1-959a-71d99270084d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5539","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:b67184d6-4f41-4672-af11-2e38f720caf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5539","original_object":"UniProtKB:Q9HBX8"}
{"id":"47156e03-5952-4c46-b732-76793f508d20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:f8301a30-3183-42d9-9074-dafa7d5227e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P07550"}
{"id":"d4ebf399-50c9-4638-81bd-f9da45155a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10434","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:6361a779-845f-4dc4-96fc-6d0562ed9126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10434","original_object":"UniProtKB:P22748"}
{"id":"8337ad6b-6a12-4c5e-8e39-8ffa9e1b1bef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2244","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:29a4db74-5340-466c-a52b-65fc7eabd4f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2244","original_object":"UniProtKB:P30559"}
{"id":"e86cfa69-82cf-483b-9aaa-0676bf057bbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:507","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:c86c499a-bbd3-4e5f-b2e3-8f1cff79b2fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:507","original_object":"UniProtKB:P43140"}
{"id":"10f4ebb5-18bf-4c23-9024-41725379ea6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:415a6025-f9e6-4496-9067-54ae144dfcdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:346","original_object":"UniProtKB:P08173"}
{"id":"65033d59-ba05-4e04-a200-11e163e55c56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122690758","predicate":"biolink:affects","object":"NCBIGene:5209","sources":[{"id":"urn:uuid:6111ff1b-24f0-4db5-ae4b-509c9b0b5250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10125","original_object":"UniProtKB:Q16875"}
{"id":"81d949b7-bd5f-46ee-b8ff-6781b894366d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66560622","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:a2bcd5d6-4748-4a53-ad98-3a71298b9315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7869","original_object":"UniProtKB:P39900"}
{"id":"2d2b7d22-1494-476e-9414-739e2e6ad566","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"UniProtKB:A2ARP9","sources":[{"id":"urn:uuid:48b14c13-9eae-4fd5-b5a6-09cbedb914a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:A2ARP9"}
{"id":"9a2eabbe-c26c-4447-9a73-8b6e2fde4960","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231605","predicate":"biolink:affects","object":"NCBIGene:2744","sources":[{"id":"urn:uuid:0d46ec59-7f4d-49e2-be99-3f3575cddf90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9053","original_object":"UniProtKB:O94925"}
{"id":"e2d834f0-d79b-435b-84ba-061aa3a5b304","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593556","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:5497a219-bd30-4667-8291-6ec77d51196b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10493","original_object":"UniProtKB:P14618"}
{"id":"aa51262e-a1aa-4bb0-a0bc-444bf6bdf680","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92762","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:45a1d0b8-be20-4d26-8ba7-42f2d84d211c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:274","original_object":"UniProtKB:P31388"}
{"id":"01f8e9c3-0bd2-4ca2-bc74-1c4eb60d88cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28852","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:f8227136-998e-4e6d-8767-c6dc5059778d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5412","original_object":"UniProtKB:Q8NEC5"}
{"id":"74073bc2-9200-4655-8280-48d33bf869f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135686","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:0758c998-89b8-4295-9873-b59b5bd3c34b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7471","original_object":"UniProtKB:P41143"}
{"id":"f849155e-a1bd-42bd-9467-baadc4fd68ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q77EAZ9TG9","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:63e014c1-1c39-4ccb-91f3-e2fa827b597e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8434","original_object":"UniProtKB:P14416"}
{"id":"3dd97bef-255c-42f6-9ef8-7a50ff4db354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604840","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:ef3ca69a-6f50-468a-b1bc-18ffc2b176d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:126","original_object":"UniProtKB:P28222"}
{"id":"9c0c66a9-592d-467f-bd2b-2de9f44e10a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:753","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:341fde49-b279-4e7c-927c-726771462865","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:753","original_object":"UniProtKB:P51681"}
{"id":"95dfb288-45e1-4f4e-9d87-66787b51779a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3806","predicate":"biolink:affects","object":"NCBIGene:7253","sources":[{"id":"urn:uuid:875ec518-e158-402c-b45f-98972d024fab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3806","original_object":"UniProtKB:P16473"}
{"id":"d86a647d-0c4d-456a-874a-77cf839ee564","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10483085","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:b1db35d3-49a8-42c2-bc6a-3477e79f8338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2121","original_object":"UniProtKB:P21452"}
{"id":"09867c29-4656-4c40-8727-6e91363a4858","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XX8E5WP7FS","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:b82ae287-18a3-4091-b101-d07c9e7d854a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10257","original_object":"UniProtKB:Q16288"}
{"id":"f12ccadd-dcea-4500-bc23-60c335550800","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137213562","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:8f303868-bc06-492a-b9d9-7cddd47c1f86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10676","original_object":"UniProtKB:O95271"}
{"id":"4fbfc0cb-d204-447d-afab-ab678da50d03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75998","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:174d063b-c6b8-4b29-b7e8-2193323351eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6495","original_object":"UniProtKB:P36507"}
{"id":"7214c5b3-1677-43c2-b42e-26f816dc607a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230904","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:dacfe701-5c45-45fc-9cad-90a33a54f015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:932","original_object":"UniProtKB:P21918"}
{"id":"84a70a06-80e7-4664-b4ad-aefc60a2eaa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L1Q2K5JYO8","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:2b5f99e6-24fe-496b-bb0e-8dd6ce36e6e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11672","original_object":"UniProtKB:Q06187"}
{"id":"bd371577-aff8-46d6-8830-a23095480cff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSZ0E9DGOJ","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:9dd7bba9-9aea-471a-8cb2-796a6326304b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4146","original_object":"UniProtKB:P34903"}
{"id":"caf5ba3b-76d3-4dbf-bb24-35b20aec4337","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34725","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:47e1c152-6fbc-466b-931f-f9445d752566","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2403","original_object":"UniProtKB:P48542"}
{"id":"3171ee87-3d60-4d43-b6cc-cb17a5500e8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:9d0b013b-be4d-433d-ada3-f487d1fad699","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08485"}
{"id":"e6760ea6-112e-4e7a-bf16-051ae40174bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Q7R99CKV2","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:241402e2-5c1d-48b7-adf1-c1626a657f32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10220","original_object":"UniProtKB:P22455"}
{"id":"706dc499-30b1-46de-9c24-ed0b75054fd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9870500","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:29acc7e9-6f31-42cf-a232-5c188287a85d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:75","original_object":"UniProtKB:P28222"}
{"id":"b6329652-dcc3-4c27-875e-71e77a0e7252","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229522","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:c97f3f98-303d-4242-9cca-7efc8ba482d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5510","original_object":"UniProtKB:Q96RJ0"}
{"id":"7759140e-563f-4d1a-af0f-5148720e1a2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GA36S2O9C2","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:a957f5b9-a1e1-43c8-aa1a-1ea85ec880b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4245","original_object":"UniProtKB:P42262"}
{"id":"bc20897c-362f-4343-b999-ad890c7b3a32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11675054","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:fb5de407-b378-4b5c-ab23-f09d9feadcfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8160","original_object":"UniProtKB:P24941"}
{"id":"04cc3e46-7209-4644-86b6-d3a03f1b3dd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10454","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:90b41edf-49bf-4f92-955c-ebdaa2a3caa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:948","original_object":"UniProtKB:P21728"}
{"id":"f45468e7-b1cf-402c-bcc4-2d168557bb7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0449O95Z1J","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:74c5899c-84f1-4d3a-849c-64f072334f37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:58","original_object":"UniProtKB:P08908"}
{"id":"82e6891d-5116-4fad-9c63-344762a10b80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8412","predicate":"biolink:affects","object":"NCBIGene:4017","sources":[{"id":"urn:uuid:73cee44b-5f97-457d-bb5c-9fd47ca1bb4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8412","original_object":"UniProtKB:Q9Y4K0"}
{"id":"25119159-6221-4b6d-98c5-c5cb8b0837f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:f41fb76f-d121-47bb-ace0-2cedd53663ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P25099"}
{"id":"80b79689-2ead-4906-b662-58a18b882720","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755030","predicate":"biolink:affects","object":"NCBIGene:4597","sources":[{"id":"urn:uuid:774252fd-1684-440b-9c29-111720fd15cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3206","original_object":"UniProtKB:P53602"}
{"id":"8484edf1-116d-4070-a254-27a729a2c30c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZD6AG3N96D","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:1fcdbc89-ce9d-4baa-a4a7-cd64c9c127a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:176","original_object":"UniProtKB:P28335"}
{"id":"d28c08ef-3972-453f-b91d-c8b83ab53433","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817487","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:d61e9967-99cd-442e-9aaa-2f72ac377ce0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6130","original_object":"UniProtKB:Q62805"}
{"id":"5a89d45c-ef2b-48ec-acfe-cc14bc838031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2JGY63UVRO","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:d086340e-fe4d-4732-8c62-5314c07fea1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3451","original_object":"UniProtKB:P08235"}
{"id":"e917c145-1fb0-4491-bde6-15f0ad110ac9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1IGV6WTK9I","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:f7d10541-7ca7-4f72-b062-d96da4fd3741","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2173","original_object":"UniProtKB:P37288"}
{"id":"29005255-ab81-4c53-8079-a198cc7b419c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147002269","predicate":"biolink:affects","object":"NCBIGene:440275","sources":[{"id":"urn:uuid:b4a0b93b-20f0-4de9-8d00-c51ebc86c0da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12236","original_object":"UniProtKB:Q9P2K8"}
{"id":"7a7f71a5-74f3-4f73-bec1-2cb817eab67b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47780","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:c7f638d9-6064-4af8-93f4-17fa26db12b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2398","original_object":"UniProtKB:P35348"}
{"id":"0dc04648-b68f-4162-b66f-18ee02d249dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75984","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:269ce115-af37-4760-876e-455dd3b99d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2560","original_object":"UniProtKB:P15388"}
{"id":"cdb29eec-7edb-425a-a7b3-03557f13a071","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10167713","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:eed50eb0-2f4d-4ab4-8138-0d71657d6a62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:839","original_object":"UniProtKB:P49682"}
{"id":"b14fc3fb-3682-470c-93e1-9b9c8223ea70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433310","predicate":"biolink:affects","object":"NCBIGene:9730","sources":[{"id":"urn:uuid:f529176b-f00c-4fa3-92f3-5ef19e1b2991","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12816","original_object":"UniProtKB:Q9Y4B6"}
{"id":"fe60394d-c63b-417a-9337-03a4503f473a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9139","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:c46ff0f9-9289-4f07-9a1c-c45c29ee87eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4743","original_object":"UniProtKB:Q9NPD5"}
{"id":"b0995b0c-7ba4-4d0c-8f8d-3fb9eb55ed74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42519285","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:fcc3dc62-b884-4caa-b0d6-25cb7fc433d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8591","original_object":"UniProtKB:P08912"}
{"id":"b91a2cf3-f115-453a-b663-9ded07144b28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:b5a8d7c9-f0ec-41df-8376-f370e0ea36f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q16620"}
{"id":"1dcf9eb2-e11f-4a59-a4d1-d2f8dd67a5e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:54b0919d-4434-4a51-853a-cb7bf88e01fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P43140"}
{"id":"8c850811-b1d2-490e-8be1-0cd45a17ac54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23001780","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:175900ca-fd3b-4fb3-9a4e-5ad6e76524b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2649","original_object":"UniProtKB:P10276"}
{"id":"e01d5728-d06a-44c8-a25b-4b25f74482a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145994","predicate":"biolink:affects","object":"UniProtKB:P0C6X7","sources":[{"id":"urn:uuid:a685da94-28e7-4f32-9e54-a9a922dbffdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10715","original_object":"UniProtKB:P0C6X7"}
{"id":"c09c1217-5d6d-4c18-b65e-97896edad5a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340157","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:5ecffa87-ce8a-42b8-9d15-97fe7446d2a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:434","original_object":"UniProtKB:P29275"}
{"id":"70fbc212-7e44-4cc8-87e8-c405a63c3865","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67237","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:56970625-dca8-45ca-a1e0-464cb29b3d14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2742","original_object":"UniProtKB:Q13133"}
{"id":"1ad62a7b-fba6-4db9-843a-c14cd836c9e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918513","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:0e15e2e5-5d33-495c-a20d-b1cfcc9a122e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12","original_object":"UniProtKB:P28566"}
{"id":"9b882484-0bd2-44f0-9dce-4b81a929f3f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44570860","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:7d784e72-5784-49c1-a122-783657dc5ded","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6709","original_object":"UniProtKB:P48449"}
{"id":"06e34f31-157e-4b9b-9d18-0353356e4e34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2549","predicate":"biolink:affects","object":"NCBIGene:3747","sources":[{"id":"urn:uuid:7759c8a6-1d54-4864-a812-fcd702d5790f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2549","original_object":"UniProtKB:Q96PR1"}
{"id":"ff5c2818-c7ff-43fd-967f-83f39718f136","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15811","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:cbed5b81-c0a3-4ca1-9b45-2d84d52a10f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1411","original_object":"UniProtKB:Q14833"}
{"id":"539bbd3f-0f18-454c-8616-e85dd70e3a14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:ccf05e7a-8505-428a-a246-ace494c52216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P34969"}
{"id":"dea63121-0b62-403b-aeb8-58742c62a57e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141521","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:9f67097f-2dad-44a8-ad44-733985be6f60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6455","original_object":"UniProtKB:P12821"}
{"id":"e468302f-47f2-453f-bf88-2a9ec6dbbb44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3175","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:4caa5af2-acab-4461-bdc9-ca0992e1bb4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:520","original_object":"UniProtKB:P18089"}
{"id":"892465fb-6826-4134-bef8-39afaa3a39d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6538","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:371b0d9d-e990-4e2b-8329-545a87a90f72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7216","original_object":"UniProtKB:P35367"}
{"id":"ffe93d8b-d3c9-4eee-b45c-78b6dc73f956","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:822","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:d749e052-6d0e-4bf3-b5ee-53eb353fc64c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:822","original_object":"UniProtKB:P25024"}
{"id":"627a07ee-68ac-4b2d-9097-7b369b334e91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Y1PJ3VG81","predicate":"biolink:affects","object":"NCBIGene:65156","sources":[{"id":"urn:uuid:a1bd037e-e53e-4ae3-8e4f-9cd941b5f04b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9860","original_object":"UniProtKB:Q63707"}
{"id":"060c5d3b-0791-4414-9e4a-63e0394897c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8772","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:bc988594-4ff8-4b03-a2a6-c7f029611271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2820","original_object":"UniProtKB:P03372"}
{"id":"b5715d12-a534-4c68-ae77-84dc330c1c3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91495","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:13d7aca7-5b0c-4ab0-a06c-53be67ef60ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:325","original_object":"UniProtKB:P08912"}
{"id":"730178c4-0d73-496b-8325-cffcc263ab58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32015","predicate":"biolink:affects","object":"NCBIGene:6558","sources":[{"id":"urn:uuid:195a0c67-a266-4276-8497-8f35cce97110","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4742","original_object":"UniProtKB:P55011"}
{"id":"55253a06-66ae-4a7e-bb1d-8e1f5b93bd07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SFQ6J6N9F3","predicate":"biolink:affects","object":"NCBIGene:58959","sources":[{"id":"urn:uuid:b300d785-8e77-47d6-9956-e3a16ff3ff51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11025","original_object":"UniProtKB:P35353"}
{"id":"e3f6f943-ad60-4c56-8cab-a54204a78f95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44328226","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:8cc6df09-8325-4ed8-a1d3-c5bb26c27dd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1557","original_object":"UniProtKB:Q63634"}
{"id":"585948f2-3a8a-4904-84a5-9845e796ae34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ff4db2e1-ad94-45de-aaf6-950572c25802","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P28223"}
{"id":"33c3be05-a994-445d-9215-e0c0832a3f3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:31b02a9c-cac4-4216-b129-9b900eb86f00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P28566"}
{"id":"72bfd024-715c-4fa5-8d25-e11123067abe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9362","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:d297d124-2818-4c26-b2ac-b48064ba4827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7298","original_object":"UniProtKB:P35354"}
{"id":"93adee52-88de-4660-9922-65b652a9e4a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229220","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:311c465e-3a09-467d-b20e-f1b63268f473","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10316","original_object":"UniProtKB:P04629"}
{"id":"6948c10a-540e-4c59-b17b-dd0e2214df86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177425","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:f10ea54a-6062-4539-ae92-7e24cfa6f7f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8198","original_object":"UniProtKB:Q99835"}
{"id":"fdf4fc31-9d78-4bc5-88b6-2b9896584539","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72202697","predicate":"biolink:affects","object":"NCBIGene:699","sources":[{"id":"urn:uuid:b4ab6d05-e201-4c4a-a428-c3fbf73381b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8110","original_object":"UniProtKB:O43683"}
{"id":"2cf2a713-ecbe-43d2-8849-29121224fa51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3213","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:aa797bf9-2316-4ea6-9f4f-db6f60743172","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4837","original_object":"UniProtKB:Q9HC97"}
{"id":"b803a1f4-0182-4db4-bc1c-d8ca1b712b88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5212","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:ea3041d6-460b-46a0-84e4-b9a8432a9886","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5212","original_object":"UniProtKB:P49841"}
{"id":"27785350-b1e8-4874-be55-d58abcaae0bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B06W426B66","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:93ff2bd4-11bd-4bff-93ee-ce817a434ca8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8108","original_object":"UniProtKB:P36888"}
{"id":"cbe3fae4-50ce-4cda-bc5a-0debccc10da9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59822766","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:37de5c25-a2c5-4c2d-9ba1-188f757e4af1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5561","original_object":"UniProtKB:Q9Y2T6"}
{"id":"67367cd6-2ffd-4349-a49d-fc0c2796acea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15950844","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:ab1acba7-e72b-458e-9133-f725ce73199d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10248","original_object":"UniProtKB:O00519"}
{"id":"1c38926d-c6c9-4679-828c-119e23ac7d95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277887","predicate":"biolink:affects","object":"NCBIGene:2289","sources":[{"id":"urn:uuid:85bc9422-71e8-4bb0-9762-244a6efbcef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11482","original_object":"UniProtKB:Q13451"}
{"id":"30674086-abc6-4e1c-8799-b62d95d3d68d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1541501","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:ab47039b-b098-4132-89a7-fb1e5abaf0c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3256","original_object":"UniProtKB:P08485"}
{"id":"ac42fc25-d1c0-44fc-8bc1-a17ae683d988","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:433694d8-a553-4596-aa99-21fb2fbbee97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P30680"}
{"id":"52120a91-056b-4a93-b10b-cf1bef2a4654","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13274","predicate":"biolink:affects","object":"NCBIGene:2161","sources":[{"id":"urn:uuid:1f5090a1-6d3f-46ab-9403-11ff9aabea55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13274","original_object":"UniProtKB:P00748"}
{"id":"34eecd27-6524-42b3-8741-2338f164ca8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6878030","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:60a4782a-a95f-4c7a-a879-4dbca55610fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10330","original_object":"UniProtKB:P56726"}
{"id":"2afcf98b-1891-480e-bc30-1d5840975c38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2706","sources":[{"id":"urn:uuid:85307453-d67c-40a5-940e-f0ff564046a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P29033"}
{"id":"45924d1e-3c91-4546-ae48-af4961e59fe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118124117","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:f9d07ff1-9561-4abe-8ead-49ad61c57a42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12305","original_object":"UniProtKB:P11229"}
{"id":"69eb184e-eef1-418d-b2b8-514c28a926b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6E68796C40","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:af8f6cef-d9e2-4b21-87d9-169328d92815","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5593","original_object":"UniProtKB:P30542"}
{"id":"64368ceb-7cfa-44f1-8a0b-64570e009fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9844074","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:603d07c5-e3e8-4972-937f-dbcbfd70fedc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5568","original_object":"UniProtKB:Q9Y2T6"}
{"id":"f296333a-bcdf-4876-982b-08c4304c9f0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177705","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:d366e880-69d3-4fb0-9ef3-55c4c464d1a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7432","original_object":"UniProtKB:Q13490"}
{"id":"9134eb3e-13ad-497e-9b98-82945a10d5e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34543","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:ac2be320-1dbd-429c-8549-c444805b306a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2168","original_object":"UniProtKB:P30559"}
{"id":"f12b11d1-c0ab-40f5-9ee4-e26b36fd8605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9753","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:5236bcfb-f441-4149-9fb8-54458d8fc748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2693","original_object":"UniProtKB:Q9HCF6"}
{"id":"029eaea2-368f-4f45-9433-09167c43b112","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82701","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:98eaec9f-0648-43db-b5fe-abd9a98321bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6741","original_object":"UniProtKB:O00329"}
{"id":"642ead4d-1ade-495d-bd32-aefa0aa03625","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1023","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:0025777c-f75a-40ab-9337-e83de9625979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1023","original_object":"UniProtKB:P21462"}
{"id":"d651824a-57b8-46c2-8e1d-4753a0850986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:2bddd791-5a45-4933-83d9-0ba2fad2536a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P0DMS8"}
{"id":"2cc3116a-3d6c-4b17-9e64-f8ab13101add","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90531","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:fbc39d6f-b62c-4143-b658-34149216e6f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7946","original_object":"UniProtKB:Q04759"}
{"id":"a8bdfeea-6c54-498c-91d2-a482b652b182","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44573698","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:c036411f-a072-4cc6-820b-1349447e60ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6205","original_object":"UniProtKB:P23385"}
{"id":"09a9eb1f-b605-4f8f-8a30-2c22b400f3f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9598","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:52ba8839-4ce9-463b-96e0-97ed739e4e35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7604","original_object":"UniProtKB:P08253"}
{"id":"b852d52e-c8eb-47e2-8cfc-a58b5254263d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:628","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:46a1596e-a9f3-4fc1-9cbb-bb13a898f204","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:628","original_object":"UniProtKB:P52500"}
{"id":"493e54e0-ef07-43c6-b0ab-5381920f8059","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165150001","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:a0fb72a7-b897-4ca0-b021-702b5bd46d18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13808","original_object":"UniProtKB:P15056"}
{"id":"20b69945-60ea-4b58-b3d4-a1d41ef6f4a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164437","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:0e54e758-6c5a-41e1-a199-a15752500976","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:373","original_object":"UniProtKB:P30542"}
{"id":"b0b8bae9-a765-4c89-9140-a3ad4a80ae03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3441","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:8d17a4f2-cf5b-45e7-9911-1a2d2cd3ff7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:551","original_object":"UniProtKB:Q92736"}
{"id":"2f8ca05d-1a5f-4c7e-ac56-5546764d9a53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188680","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:f0246549-9095-4895-b939-f4716f94efad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4587","original_object":"UniProtKB:P13866"}
{"id":"ae0409b6-9492-4712-9144-c4beffc7d11b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94977","predicate":"biolink:affects","object":"NCBIGene:6839","sources":[{"id":"urn:uuid:789014d5-1982-435a-a734-26e2fcc9eb89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8388","original_object":"UniProtKB:O43463"}
{"id":"f8fb5cc6-ea4c-4290-b609-b41ed355f207","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:1a3216bc-237a-4346-9d5c-c459318bc841","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:Q14832"}
{"id":"5d945733-b15e-4603-9163-f508db9f344f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:330953","sources":[{"id":"urn:uuid:4d5ed367-7b48-4ea7-9e4a-da7588dde45f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:O70507"}
{"id":"a03d73c7-6e75-4811-8eb6-02d8122ab175","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6804","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:effc6bea-5845-4b72-8a7d-60e91b68165b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7438","original_object":"UniProtKB:P08485"}
{"id":"6d2b61dd-9c00-4e6d-b4e6-20f916b89cd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54580880","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:a89e1971-c9ed-4507-8994-ff498a2521f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5745","original_object":"UniProtKB:Q8TDV5"}
{"id":"a86247d9-44a7-4380-acc4-934da0af5b95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135697","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:d6b66546-224f-453d-b34b-70af1fd05cff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:210","original_object":"UniProtKB:P28335"}
{"id":"9ccb6ced-bdb2-4e5d-8653-9b65229ca56f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:1effd38b-f15d-4632-897a-e1b1347aa0b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P30994"}
{"id":"738b8151-a05a-4d05-a5ca-2f90e1db4d03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136043","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:e2e6c71e-d9d2-4745-b267-031462d73fbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11582","original_object":"UniProtKB:P27487"}
{"id":"8ef46663-926e-48d5-8d5d-c916e4f03b95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:7006386d-7531-4e4d-98ed-8735469ed986","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P41595"}
{"id":"c1d0ff31-b1f3-488c-81cb-a9885213e292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45376872","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:88be7ce6-afb2-41cf-af5c-cb48efbdcc3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8636","original_object":"UniProtKB:P45452"}
{"id":"3de2e688-6d2b-4f43-8760-d6f91104ab1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44560289","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:ed706b14-1219-4e6a-960c-f42544d77a5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3536","original_object":"UniProtKB:P51677"}
{"id":"030f4e67-be58-4905-8d3c-bbf1473cab75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32090","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:982dbf79-6f27-409a-83c5-bcf603beee08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:871","original_object":"UniProtKB:P30551"}
{"id":"75ec369c-f964-4bbb-baf8-dfc62aa741bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135694","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:e2105f88-2d62-4560-b35a-aee2772cfca4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2197","original_object":"UniProtKB:P47901"}
{"id":"dc60c41c-548c-42e5-807f-720f52b89f80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59001466","predicate":"biolink:affects","object":"NCBIGene:6534","sources":[{"id":"urn:uuid:cc07ce15-8472-4038-980f-7d2efe1b310a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4576","original_object":"UniProtKB:Q99884"}
{"id":"20660b0a-49ac-42aa-8444-b87d929722a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92733","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:560aa9ca-b1d4-4903-a001-25f63188c5c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1703","original_object":"UniProtKB:O43613"}
{"id":"b5322b07-45df-4b9d-9604-26be0a3fc556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:40cfdfc6-37c1-404d-b886-95e7f11a9248","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P34980"}
{"id":"b3043a58-2515-43c7-aade-1f874713ce89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155818902","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:4dac1bb4-23cd-4697-9d66-4a3927a1883e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11701","original_object":"UniProtKB:P0C6U8"}
{"id":"b13bd267-90c6-4801-9355-9e988a342bf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111172","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:a24e66f3-1e60-493a-a331-f710cdf15052","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10742","original_object":"UniProtKB:P21728"}
{"id":"d449be2b-e71e-4a5a-aa3c-23d577c8a46a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:a353a9f8-375d-4cf8-92f0-589f496f7c73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:P15389"}
{"id":"9afea6c5-cd58-4b3d-bf69-8a2a9c777ad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:9eaefe43-7895-45e8-a6c7-8b3cfbf34657","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2455","original_object":"UniProtKB:Q8TD43"}
{"id":"26280c27-1468-4421-ae7b-34757d7b91cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:e8ff3b8b-8b9e-442b-a1ec-934b38bacea1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2340","original_object":"UniProtKB:Q9HCF6"}
{"id":"8174f33f-0d79-49c9-8488-1c71bb0a8c25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16349","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:84af209a-8508-4f07-b32b-af42192b17c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:722","original_object":"UniProtKB:Q5T6X5"}
{"id":"5b6447c6-239f-4f78-bada-ebe28d708329","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:446400","predicate":"biolink:affects","object":"NCBIGene:5320","sources":[{"id":"urn:uuid:b267962a-eb50-44b4-9f5b-6883408b84b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6703","original_object":"UniProtKB:P14555"}
{"id":"eb41ea58-90d3-45b3-a4b3-61281fc93e0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UKI9MLD5OI","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:16cfd2de-2962-49b1-b831-5cef3c22c371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:164","original_object":"UniProtKB:P14842"}
{"id":"84e0a9b7-cce6-42fa-985c-d49ca8b91021","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94038","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:b90a352f-1586-42c4-9b63-9d7b8b07159b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:300","original_object":"UniProtKB:P20309"}
{"id":"64a376d8-9d71-4539-bdf7-74ec572fe6c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1732375","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:ded35c50-b136-4adb-aa6f-4773ce53a59a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7720","original_object":"UniProtKB:O95180"}
{"id":"7ce13859-f85d-40ce-b730-30db91d42351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2B75NX3MA8","predicate":"biolink:affects","object":"NCBIGene:29694","sources":[{"id":"urn:uuid:2e8e8306-9438-49d4-99f2-f4b9f7f7218f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4148","original_object":"UniProtKB:P50572"}
{"id":"3be89184-2945-4c98-92b7-c28af3eb785d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5855","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:5053f05c-de19-483f-8048-540a51e51876","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2713","original_object":"UniProtKB:P35354"}
{"id":"04e5324b-4658-4c8c-87b5-0b5944f59f10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44457632","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:0d9883e9-f065-45be-baa6-043fb15cf62b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:905","original_object":"UniProtKB:P56481"}
{"id":"e9bebf51-879c-4d31-a82f-7b7d2a7379af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94490","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:2c3943b3-c761-4da1-8b2d-b4d7d49acada","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7937","original_object":"UniProtKB:Q96GD4"}
{"id":"6d227f5b-36ef-4ad4-96e9-dc734f747699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:13609","sources":[{"id":"urn:uuid:44583288-188d-4e11-8a7e-a9f17f622b10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:O08530"}
{"id":"666a115c-b890-4e44-8d85-6a8d4e0f64c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1HLS600135","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:e3d3a4dd-fbb7-4b53-bd1a-d6fdf6903898","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:489","original_object":"UniProtKB:P43140"}
{"id":"6fcfc3ab-2a34-4b9a-9b13-352c467df971","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:96ed8a57-7d04-4ada-907c-03470085ad19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:Q16832"}
{"id":"4c02ab55-b928-43c5-9f0c-652d66e5ceb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3778","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:cd2a2e9d-124c-4eda-bc0b-daee048a4180","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3778","original_object":"UniProtKB:P30559"}
{"id":"346359af-3021-43d9-9707-fee39bf97704","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:6ff5b9e1-1a40-4bc3-981f-31da689d9592","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P29275"}
{"id":"01d0d54d-91c3-469e-8faa-a8dd0195c65b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"UniProtKB:Q61618","sources":[{"id":"urn:uuid:3146e6ec-6af8-47e3-9581-8553956dbc05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:Q61618"}
{"id":"7e956205-85d3-4d4d-9798-456f4e7406e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4554795","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:e328679a-8cfe-481d-b2da-c72565493a94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10425","original_object":"UniProtKB:Q13464"}
{"id":"938f59d8-d293-43bf-b892-2dd307d1346e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17489","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:01e953b8-5e7b-4814-87d7-748907342bf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2352","original_object":"UniProtKB:Q00195"}
{"id":"4ac76ae5-b5a4-435c-ae89-5cbdf404d4ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VFC23V742Z","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:24584015-ef40-4268-9104-6f54352820ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1619","original_object":"UniProtKB:P41145"}
{"id":"cd6d8e83-f26e-40e9-bd26-22be40637e5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129053583","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:d48d3d9c-b3da-4dbd-907a-b63e27754a90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12510","original_object":"UniProtKB:Q9NWZ3"}
{"id":"ef07615c-7bd8-4cd5-b6ee-c10ba1104f7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:441P620G3P","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:8973c701-116e-489d-8dc1-a7e012b8b7b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9426","original_object":"UniProtKB:Q9UBN7"}
{"id":"233e85d6-8a35-46c5-8e56-589fa32b921c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754993","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:30f4c685-820c-4c77-9059-5ac60076b9a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:436","original_object":"UniProtKB:P28647"}
{"id":"f84d8f34-8c73-4f12-8e41-708cd7f20fb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5959","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:16d715ff-58aa-47d2-9ea2-3287c0771d12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:589","original_object":"UniProtKB:P30556"}
{"id":"b67945c3-a1f6-44c6-9e0b-859e00fb7e3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:c56442c8-fad2-4155-85ba-ec5d104019df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P25099"}
{"id":"df7e7c37-94d1-4ef4-8cd5-ec945e525fb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107660","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:38cd53cb-0e91-47c0-8a57-e16f08acb293","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2361","original_object":"UniProtKB:P23416"}
{"id":"2cafc6fd-c6fb-47c6-a9e0-cf68a21df157","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:6f4c7977-f625-45b2-8d62-ef94f26879a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P31388"}
{"id":"fea92f7e-b7db-4813-96c4-6aa4daca50db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:cc0933e5-55be-402d-9c71-7a0b12fff76b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P35346"}
{"id":"cac7fff8-a352-4749-9d61-bad5132dd52c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47458","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:9501b29f-a698-4a2b-934e-dc97c1910cf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7731","original_object":"UniProtKB:P12931"}
{"id":"c2640807-8ea8-4dd9-9f42-9c1a5399f920","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:a840711f-5f28-40c8-a9c4-b936d59fc46d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P08908"}
{"id":"fb64a07a-be39-4521-8bb6-591a600606ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"NCBIGene:57144","sources":[{"id":"urn:uuid:30c76271-a819-4266-b4c0-7bcfda2b5865","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:Q9P286"}
{"id":"7c5e07b3-d733-4ff7-8aed-521a197c8298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:e9e3692e-ac1d-4a60-985c-8e5b2acfb926","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:P51787"}
{"id":"5854f398-9580-4301-8139-085eecb5ac8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:0748f867-545e-4e39-931d-f55779add4c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:O14965"}
{"id":"0f1cf9a5-3693-46aa-a0c0-3a8743983a23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2266","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:5b9f0c61-8fb3-4e89-90b4-22d418b5d5af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2266","original_object":"UniProtKB:P32241"}
{"id":"546dbabe-7ac7-4589-ac52-87e71d48fe04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:469","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:bf6d5192-657a-4e9a-9f13-cf136816c9c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6298","original_object":"UniProtKB:O75762"}
{"id":"81f0297e-e406-4d17-977d-f56855d6abd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146267141","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:e4420efc-fde2-4ea8-b2e6-def3dcb69e6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12075","original_object":"UniProtKB:P42338"}
{"id":"15c2b030-7d1a-42b4-9a80-453120057f85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81391","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:1c9499be-00f6-4f7e-99a4-882ecffc4033","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1267","original_object":"UniProtKB:Q9H3N8"}
{"id":"654d412e-dbb4-40c0-a4b9-73f9797ac8d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168990978","predicate":"biolink:affects","object":"NCBIGene:5167","sources":[{"id":"urn:uuid:1921a370-1386-45ce-93ba-3dfd325da654","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13937","original_object":"UniProtKB:P22413"}
{"id":"cc5dbdeb-9f1d-4dc8-ba4a-ee2cab18b74b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46233650","predicate":"biolink:affects","object":"NCBIGene:2158","sources":[{"id":"urn:uuid:e930f31f-3d8a-4fb6-b82a-47d63ebfd4c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6550","original_object":"UniProtKB:P00740"}
{"id":"a11fccfa-d556-4003-a350-0e5d5e7d462d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90217","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:61bcd757-bd2f-4613-94ae-c9b3e9d6ab44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5658","original_object":"UniProtKB:P07333"}
{"id":"3ef5c57d-3cef-4918-a5a7-5aee67fa18f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14016348","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:3de54b9f-8b27-4973-9139-ad1ca3b57aa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:452","original_object":"UniProtKB:P29275"}
{"id":"9c3b45c6-79cd-47b9-b24f-d055b2684020","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132290","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:c6833f02-6f6a-4857-8967-3caa6c5d7b3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2548","original_object":"UniProtKB:P16388"}
{"id":"c19f9152-b526-47e0-bf6d-2e902797cc6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:94e411bc-d122-430d-bf75-eb2c276bc79b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:P06239"}
{"id":"d5a289e7-113e-4c3f-8c16-8b625fd5f681","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47781","predicate":"biolink:affects","object":"NCBIGene:25553","sources":[{"id":"urn:uuid:9e2837a9-72b7-402a-83dd-73ede8d69c6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2399","original_object":"UniProtKB:P31652"}
{"id":"6533b737-56f5-43c1-9fd2-179c79efcb64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"UniProtKB:P29319","sources":[{"id":"urn:uuid:10ca43ca-09bf-4324-b81d-9375df08de07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P29319"}
{"id":"de342d11-39c5-459d-8c14-9fbdc4d3b440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817413","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:8878ddac-8cfa-4a8f-92fa-4a423eb88f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1474","original_object":"UniProtKB:Q9GZQ4"}
{"id":"3c9cec50-3e6c-4cc1-99ad-4c17f10dead5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73294","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:ddb2d494-df6f-4160-b6be-6b0e7f7d1446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:676","original_object":"UniProtKB:P32299"}
{"id":"eb034c14-5835-4f6d-aff8-70db35804fa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:2268","sources":[{"id":"urn:uuid:b19d04e1-390a-495e-97c3-fbd2aa54c3ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P09769"}
{"id":"2fcc2190-d0cb-4eac-add7-b1d6e66d271c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072559","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:7469e736-571a-42c9-bb95-e83ee4394e79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9009","original_object":"UniProtKB:Q9HB89"}
{"id":"961eda23-e919-4a31-85c0-6668d782bdce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47097","predicate":"biolink:affects","object":"NCBIGene:4893","sources":[{"id":"urn:uuid:775a452a-0b68-497e-b6ae-6a0cc883968b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8024","original_object":"UniProtKB:P01111"}
{"id":"743f5d84-7bff-4ffe-b796-e9844770b5f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486504","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:27f02ed5-7e7f-45bd-b4a6-dc7c20776747","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8811","original_object":"UniProtKB:O76074"}
{"id":"4d270a3d-e47e-4015-b040-00300d4dfc29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1Z83587HBN","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:c4b175ad-ca9e-4898-bb4b-1dab4bfb17c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8487","original_object":"UniProtKB:P31391"}
{"id":"0cef814a-ed6b-4082-8d75-2a9573a6bdad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:398ad45d-9ef4-422f-98b5-46e1e21274f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P14416"}
{"id":"1391c4b6-fc4a-4f7a-bf71-c2c5db7331fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91433","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:0b69b489-1034-4e11-be9a-97d8e37e1317","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9383","original_object":"UniProtKB:P10721"}
{"id":"af2c4e4f-c3f2-424d-a4d7-a2a79cf4104d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:0eebdde7-ef60-4b76-a007-865a4efeaf95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P32305"}
{"id":"a063b59a-35c1-46b4-9622-61a641ff5373","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:309212","sources":[{"id":"urn:uuid:42926a74-0946-4ff3-b650-ec2e89c1bf66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:Q6XKD3"}
{"id":"6e3d4523-649f-4fab-9bbf-ec6013957242","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CW55R761RE","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:87adeae5-edf2-40d3-84fa-5648f10655fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:290","original_object":"UniProtKB:P08482"}
{"id":"d5b1f73b-f36b-41de-a0ad-31cc553606c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13398","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:8de874da-9819-43bf-aff2-b8679a8891ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13398","original_object":"UniProtKB:Q16769"}
{"id":"51cf9390-73b8-4794-b53a-23c59290bffc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3033941","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:6fd1bd49-344b-4a61-b29f-ff69b815ea65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1730","original_object":"UniProtKB:P41231"}
{"id":"a0873480-a767-48af-9c32-e48b1927c321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:828657d1-7b28-4a93-8a07-f93a0f98535e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q9UQL6"}
{"id":"2b811c91-9731-4bdd-9abc-b9c15a5c4d2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155213164","predicate":"biolink:affects","object":"NCBIGene:6506","sources":[{"id":"urn:uuid:a370b945-4236-49e3-82e5-bf94ff88ef57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12135","original_object":"UniProtKB:P43004"}
{"id":"38ab1b69-026a-4c30-b220-9950b810d8ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2564","predicate":"biolink:affects","object":"UniProtKB:P17659","sources":[{"id":"urn:uuid:d0ddcf2c-aefe-42fa-9ecc-152eb1341805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2564","original_object":"UniProtKB:P17659"}
{"id":"e579a2ff-976f-420b-948e-04790ad7441c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15366","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:8a483a2e-7aa3-4511-b074-0e0faee309cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1058","original_object":"UniProtKB:O14843"}
{"id":"29cd9eb7-dfb9-452b-a820-d8a71e9581d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6420160","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:716f3c1d-dd1c-458b-92b2-c52ddaccb25d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4092","original_object":"UniProtKB:P39086"}
{"id":"2c1297c7-d830-4ff9-8a23-b0860aeefd14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"UniProtKB:Q61618","sources":[{"id":"urn:uuid:008a3e46-b555-4899-8de0-590b2cc718b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:Q61618"}
{"id":"db31e07e-96de-49c7-81be-f768d4f92c4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9929033","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:c63ae4c0-7730-44e8-a1b4-a6674945b14b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:233","original_object":"UniProtKB:Q13639"}
{"id":"cdbc22c2-862a-47d5-909b-c2e7ced11145","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25229528","predicate":"biolink:affects","object":"NCBIGene:25989","sources":[{"id":"urn:uuid:b1523a04-eb2d-4efa-a6e8-0c8e6316e551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8220","original_object":"UniProtKB:Q6PHR2"}
{"id":"82d7e49a-d5f1-4189-b39e-347b7a655a2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1044","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:07033bd1-419e-4b50-8252-6cc68a758a8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1044","original_object":"UniProtKB:P25090"}
{"id":"39fb92a7-9093-4d55-9e78-863510c18351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1Z83587HBN","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:5e268b99-d48d-4acd-a4d0-f5b433880b74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8487","original_object":"UniProtKB:P35346"}
{"id":"536d9a79-a6fd-468b-a127-5df9ee972b5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56593482","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:afea132d-6db3-4c3f-852e-19116fa5bd2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7650","original_object":"UniProtKB:P14416"}
{"id":"b9908785-08e5-4804-9e52-249f6f585e0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92740","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:be974d32-0931-4b1f-8b56-35eca781b215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5917","original_object":"UniProtKB:P00533"}
{"id":"5dda8a0c-45de-4805-a808-6fd2fd81bae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2261HH611H","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:90b646dd-caf8-4216-8af5-23e5a344f749","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9907","original_object":"UniProtKB:P48736"}
{"id":"6976d5ee-e4f4-4527-889e-451ddddc7296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VR86R11J7J","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:55d5c668-2b69-4592-abd8-66f6e97703be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9117","original_object":"UniProtKB:O60885"}
{"id":"8acc6bad-3786-4973-9702-1c56255338ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5VWV92039E","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:4ab0a894-21b1-4c31-afd7-3c342d5be09b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2834","original_object":"UniProtKB:P62508"}
{"id":"f052e83c-1131-4caf-a08a-54a849831e09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71582672","predicate":"biolink:affects","object":"NCBIGene:80168","sources":[{"id":"urn:uuid:b7b54e85-869e-4ccd-90c1-58204664468e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12738","original_object":"UniProtKB:Q3SYC2"}
{"id":"9a7f3bea-86e7-4ef5-a5d1-c9ec4216aa2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50202","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:81bd2ca8-0777-4f27-89bf-8e4ed2698324","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10298","original_object":"UniProtKB:P59534"}
{"id":"fc8d8a4d-4a11-4f6b-8f7b-90d119f943d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7385","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:8cfb3841-9a43-4703-9455-37fa35bbe20d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7385","original_object":"UniProtKB:P07766"}
{"id":"452ce665-36ba-43fd-9b97-97c7b16ed209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:12adc131-28ba-4e5f-822d-cc740c594a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P10721"}
{"id":"c6d7c3b1-0170-419e-ae6a-34dfcc06caec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59896759","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:e0bbf359-287d-4c44-a7a4-c8242c4dccc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4369","original_object":"UniProtKB:P48169"}
{"id":"62e85201-3b86-4082-b237-b1e102412aee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993636","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:33a3eb5e-a346-4489-98c0-611cc945026c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12351","original_object":"UniProtKB:P51449"}
{"id":"37abb2fb-04cb-4ff5-ac33-adbcc8e985d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688690","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:311cabf7-331a-463b-99bd-051a7cea8ad5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8118","original_object":"UniProtKB:P53671"}
{"id":"0d87cd1b-5f9f-4adb-9cb7-fb81e625cce3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL88553","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:19ab9342-9e4f-4d44-9e4c-00e0af0e1044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1431","original_object":"UniProtKB:P41594"}
{"id":"09e665bc-0df5-4395-aa04-bea9d63f40da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69586250","predicate":"biolink:affects","object":"NCBIGene:2167","sources":[{"id":"urn:uuid:d40d4132-2500-436d-874f-2ae5145277d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8797","original_object":"UniProtKB:P15090"}
{"id":"286418ae-7a16-46ff-9134-a3921a7dce29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:2835","sources":[{"id":"urn:uuid:cd4fd97d-050a-430d-8502-ad2bd8a0127a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:P47775"}
{"id":"8acd79f7-d6eb-47dc-8492-25fdc4212e86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91654625","predicate":"biolink:affects","object":"NCBIGene:11176","sources":[{"id":"urn:uuid:91c3259e-fbff-4c60-bbe1-7192e177438a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8571","original_object":"UniProtKB:Q9UIF9"}
{"id":"fcb366b3-b38a-4dd5-8736-9cbce2fef711","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4206","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:58ddd2fb-49ed-4820-ae51-6f193e018af2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4206","original_object":"UniProtKB:Q9UL62"}
{"id":"52d3ac1d-01ac-460c-9fe5-2a7ff54be4a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45307","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:47125e73-c878-4109-ad49-61bb34f57edf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6035","original_object":"UniProtKB:P24941"}
{"id":"d9ece7c0-1930-4e6f-9c12-4bb915a17f20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1492","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:f6c7eae1-558a-49ab-a85e-bc781fde0e48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1492","original_object":"UniProtKB:Q6W5P4"}
{"id":"87d5194d-2083-4750-9e55-8c7711e52843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:2f70f749-ed06-4c30-a45f-8fa9a7f0eb13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:Q9UGI6"}
{"id":"b176bfb2-12f9-4a0f-9db6-179c6cf7d9e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:f9ebf7ee-7495-4eff-a288-00fb2ada13ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q9UBN7"}
{"id":"97665758-9ff9-4499-869e-871d409fe8e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11948463","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:562f4008-0ac6-40f7-b5a5-a2ea48bde7f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6183","original_object":"UniProtKB:P21729"}
{"id":"f84098c5-d372-4acd-ba73-a9d5d907d535","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:778","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:773f975c-2bde-4a41-8730-45c276f40be3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:778","original_object":"UniProtKB:P41597"}
{"id":"2442d46d-6244-4c90-982c-17708e06e04b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2113","predicate":"biolink:affects","object":"NCBIGene:21338","sources":[{"id":"urn:uuid:14ee7d14-8027-451c-bec8-faf4ec50f750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2113","original_object":"UniProtKB:P47937"}
{"id":"8b3468a8-ae18-4cf6-bbb7-f31f7f2047c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:81fd8174-0c62-4d2b-a1ed-89291846c275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P11229"}
{"id":"c04a2c01-4428-447d-bfca-33cf099bf7b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:cfb0ed6a-b8a2-4e17-b729-7407f81f44a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:Q62758"}
{"id":"09129e81-25b0-4d71-bcb6-50bec4d60d48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9810140","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:e43713bc-5e35-49e8-ae21-a108a744965f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2205","original_object":"UniProtKB:P47901"}
{"id":"d6ee06ca-9130-4d29-87f8-5e4637920608","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8KFO2187CP","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:c541f155-74c4-43ee-ba3b-9da3c29ff66e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10190","original_object":"UniProtKB:P29274"}
{"id":"b4d49268-05a7-47e1-aa20-ad417ecbd112","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122650693","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:bfcb76a1-5f2c-4d3c-b6cf-3b084294eab6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12383","original_object":"UniProtKB:P10721"}
{"id":"7594dae3-a2ba-4a22-9a83-bcc4a230cfbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11998","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:6c4dc69b-5e87-48ce-b345-8d0b7096ca43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11998","original_object":"UniProtKB:P48546"}
{"id":"f9869351-fbaf-4416-bd8c-043c606b3759","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:aec8d051-24b1-4af5-a6c8-a98a17463108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P31388"}
{"id":"b35ea7ba-8546-46c3-bf0e-87bf370d4974","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:629","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:0550f629-8e4d-4f2e-bb30-3ea25c4a8ad0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:629","original_object":"UniProtKB:P30550"}
{"id":"46d1a0b3-53f0-4696-8fec-782b84ceea6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131358","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:1d050782-ba5c-4054-9fe1-c9e5400423c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3289","original_object":"UniProtKB:P0DMS8"}
{"id":"ec96cf17-a0a3-4558-a5a2-c50402930192","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5H2DV04I6O","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:7705387f-ddee-4981-85c8-bfc2bcdd8ee0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11902","original_object":"UniProtKB:O43193"}
{"id":"1ef8f957-266d-419b-9ea8-1f2c30afdc12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1M7NI1A92L","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:d61ff9fe-d0c7-4e57-9bc8-a2c77b4ff780","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4095","original_object":"UniProtKB:P47869"}
{"id":"ada8c8e1-2e4d-4790-a2f3-6439ba8e1c77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2187","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:b4ab005e-c109-49a1-b520-e5d60c58d360","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2187","original_object":"UniProtKB:P47901"}
{"id":"c9522a97-ef04-48c6-a4cb-66e56c2dfb67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5296","predicate":"biolink:affects","object":"NCBIGene:841","sources":[{"id":"urn:uuid:c73f6b84-072e-4d34-9f28-953a7d2f2dab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5296","original_object":"UniProtKB:Q14790"}
{"id":"0ea74ff4-28f6-4b49-895e-4c34ca99008b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45409","predicate":"biolink:affects","object":"NCBIGene:54658","sources":[{"id":"urn:uuid:1281050b-0b6e-4647-956d-a9d8b111e2e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8804","original_object":"UniProtKB:P22309"}
{"id":"9e685060-cd14-433f-a0cf-409f45162120","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947515","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:4a8ea50e-9a26-45b2-b1e6-9270559dabb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9916","original_object":"UniProtKB:P42336"}
{"id":"24675baa-8f00-40a2-bf5e-d50947486033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1469","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:41a379f7-d61e-499e-a91b-d72b5df75e4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1469","original_object":"UniProtKB:Q9HB89"}
{"id":"5b4d77a0-9fe3-4119-9a0d-69855192cfe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2087","predicate":"biolink:affects","object":"NCBIGene:21338","sources":[{"id":"urn:uuid:afecef76-a7bd-4121-9013-d61964612337","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2087","original_object":"UniProtKB:P47937"}
{"id":"6790ffde-2ccc-4dc4-85e6-028d6cab84a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135530","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:4a004788-34e0-43e2-8c43-711b75c0bf85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7483","original_object":"UniProtKB:P08172"}
{"id":"ccbadcff-30ca-42bd-9eaf-8d121419da74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107736","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:72dfe377-66c1-49f4-b3f7-9096d7aa7092","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:241","original_object":"UniProtKB:P46098"}
{"id":"8c2b59bf-e0e2-4420-9d00-89f4fd13fe3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189868","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:7d8576da-d77e-4ec6-b3e7-659d512acce0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1614","original_object":"UniProtKB:P32300"}
{"id":"dc648e88-ae20-40f2-81c0-4a7d93e46f7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10119","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:5b1c110a-1353-4dc1-9138-da609119940c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10119","original_object":"UniProtKB:P35499"}
{"id":"0a7463c2-fef0-4828-84e6-5ea1538b5d1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32347","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:6f955c6b-c858-42fe-85df-52985e8a9c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2287","original_object":"UniProtKB:P46098"}
{"id":"01683310-76a7-42df-b11a-1cf133d39e64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13284","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:70b9e992-cf97-4d60-922a-beac5804f2f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13284","original_object":"UniProtKB:P0DTC1"}
{"id":"1be6a85a-be9b-416a-b2fd-52b1cfd1aad0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145954576","predicate":"biolink:affects","object":"NCBIGene:6609","sources":[{"id":"urn:uuid:05c01df7-ddf6-4710-8cd2-bff0ea0c9f40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10639","original_object":"UniProtKB:P17405"}
{"id":"fab9e917-aa3b-4021-af58-fe247783ea7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:1394fb90-033b-43c0-8375-d67cb7471eae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9HCF6"}
{"id":"3af8ea9e-ceb0-4bd7-80cc-6eaba4510d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A10SJL62JY","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:b83f3232-b9df-4c20-a901-0ec7e7d427c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7580","original_object":"UniProtKB:P11836"}
{"id":"9c2a85a3-f7d7-429b-a673-de025c1ad1bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91885640","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:d7d2449f-c869-46f9-b053-9ac2676ab879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13191","original_object":"UniProtKB:P07550"}
{"id":"e2d11ae1-b1d3-44fe-adf9-70ec3b6b14dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63453","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:03b84904-43e7-487e-a258-c6863e4c57e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7707","original_object":"UniProtKB:P21802"}
{"id":"8396ccd5-6397-42ce-bafa-61ab1ab95b16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6456","predicate":"biolink:affects","object":"NCBIGene:78956","sources":[{"id":"urn:uuid:6bd59c29-09d6-44eb-b325-f76c8b46d72a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2623","original_object":"UniProtKB:O08562"}
{"id":"b6ae6617-5dd8-4233-b00f-fce940195d72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27485","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:41308d81-a0a7-4107-acce-dafcd85718c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1885","original_object":"UniProtKB:Q9Z2J6"}
{"id":"820424ba-e102-4d30-af8d-4608332155cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91790","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:99dc081b-5baa-4de0-932d-fc1408022a05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:186","original_object":"UniProtKB:P28223"}
{"id":"e635c282-72cb-4696-927f-261c3a219355","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49837564","predicate":"biolink:affects","object":"NCBIGene:4751","sources":[{"id":"urn:uuid:c33f193b-9b6d-4ff6-b187-1f7383e92a1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8180","original_object":"UniProtKB:P51955"}
{"id":"8940322f-5758-4ec4-ad8d-e60224e6c785","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3759","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:23687dd9-f87b-44ff-ad5e-9ea71fa47355","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3759","original_object":"UniProtKB:P23811"}
{"id":"d92c5971-5fef-458d-a50d-80b0aa8da54a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46203250","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:d3aae1bd-46d7-4876-84fc-8da7ad4633c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8690","original_object":"UniProtKB:Q13133"}
{"id":"c9c2839f-5917-434d-8bb3-95a67857e8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9U3GT3353T","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:1d949c39-7ba4-466c-966f-ed6fdcbf030a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1624","original_object":"UniProtKB:P41145"}
{"id":"2b0835d9-0618-47b9-9d12-7439eb9a4c05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311043","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:4a5a7f70-0078-4335-9e56-2bbf9ac5a6d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1073","original_object":"UniProtKB:Q9Z0U4"}
{"id":"e0e119bc-3976-4d80-ae4d-6fd9ec27214a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10200844","predicate":"biolink:affects","object":"NCBIGene:79123","sources":[{"id":"urn:uuid:41580db7-4d89-444e-abe6-e67187a333b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4116","original_object":"UniProtKB:P55926"}
{"id":"9080f290-ebe9-42a0-826a-2ae9371da420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SV2WPA4R4J","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:b083230e-2b21-4316-8ab1-8a18b6ba455a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11734","original_object":"UniProtKB:Q9UQD0"}
{"id":"055aa79d-c3dc-4dea-8b0f-77a82bd0e4f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YKQ241VJ92","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:d953e9f8-ae93-44ce-9eed-754449f6b260","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5689","original_object":"UniProtKB:P07333"}
{"id":"94bb2ee6-7e95-4bcf-81a3-6c0e6e13efff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137076847","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:449ec2e1-8d8b-4ce9-8635-5fb7a5feec2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9212","original_object":"UniProtKB:P42345"}
{"id":"0194e678-3e57-4437-a84b-ca50b8003f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435286","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:5feba6e8-c645-4fac-abd2-59875e775dc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3353","original_object":"UniProtKB:Q6NS65"}
{"id":"613f8738-cef9-431b-a27a-70b8df998ac2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311026","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:c3687276-b0d8-42e4-a7ed-70f3e07d5766","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2083","original_object":"UniProtKB:P30938"}
{"id":"cf685858-51a8-4a82-81ee-27b553cc5ae6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3GBO34D1BE","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:ca03220e-cdb7-434b-81b5-905e3dc32f80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12003","original_object":"UniProtKB:P27815"}
{"id":"d9c0967f-f227-4dcc-9f70-b246d1fdcf62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:e66b47ee-82ed-48db-9634-262184a08ee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P25099"}
{"id":"3daa4a1d-96cf-454f-a7bd-c2f0256e0bf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45II35329V","predicate":"biolink:affects","object":"NCBIGene:1536","sources":[{"id":"urn:uuid:effe121f-3ac5-4168-b000-59b3ddc4bc83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9932","original_object":"UniProtKB:P04839"}
{"id":"828a6d65-6b4b-4bda-81dc-0747161321d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8249","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:71b11ef7-f861-4461-905a-443b8a04479d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7273","original_object":"UniProtKB:P35354"}
{"id":"8c5c87e2-b32e-4d89-9a2f-9a0983591e10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44737","predicate":"biolink:affects","object":"NCBIGene:390245","sources":[{"id":"urn:uuid:48d91e47-f86f-4b33-b18a-d279c3e72d3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8744","original_object":"UniProtKB:B2RXH2"}
{"id":"8d787e5b-6ca2-415a-b243-5226fa709f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135484064","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f61a32e4-2d96-48b7-acd6-587d0354a1be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:390","original_object":"UniProtKB:P29274"}
{"id":"616d479a-cb37-46a7-b00a-c75f73b34cb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:f594e7b9-aa65-4bf4-be15-b2abe3391fb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:Q9NY46"}
{"id":"ac4d8c35-3115-416b-9812-d2f08eb732ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:19511","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:75fa92ee-f8fd-4a6e-bb4a-ba82a8f6b88b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2910","original_object":"UniProtKB:Q9H1C0"}
{"id":"a49368e8-41dc-49df-a987-8213aad9d455","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:dc06e7d9-0dfc-44e6-be65-aee8858cfa9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:P00915"}
{"id":"af20cd7f-2918-4a0f-adba-3d656b4631a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141520","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:cf6ad5a8-9ea4-4540-afb9-d94c13bdc4a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6378","original_object":"UniProtKB:P12821"}
{"id":"bdcb4251-63c8-46af-afe9-45ceeccb749d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44584870","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:c4a57626-2371-4fcb-bc32-6bd12a20f581","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3077","original_object":"UniProtKB:P37268"}
{"id":"d1d4cd54-7943-4ff5-8cd8-ef046aea57ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1Z83587HBN","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:d372ad64-36a6-4b5c-a6bb-af7e683e2123","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8487","original_object":"UniProtKB:P30874"}
{"id":"f6d49a37-cac6-45ad-9475-e0fc962ef4a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:2242","sources":[{"id":"urn:uuid:25aa6341-aec2-4a26-8b03-316e058bcdfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:P07332"}
{"id":"78524786-0964-491b-848c-b5bb2d2a7a86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136205832","predicate":"biolink:affects","object":"NCBIGene:112398","sources":[{"id":"urn:uuid:adf75b1e-d874-4965-99ba-cfe407fc5063","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8796","original_object":"UniProtKB:Q96KS0"}
{"id":"809c38fe-4fa2-4c85-8189-dd80d5230bb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164628824","predicate":"biolink:affects","object":"UniProtKB:P0DTC8","sources":[{"id":"urn:uuid:5d46ec12-7a17-49a9-869d-382fce4848e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13634","original_object":"UniProtKB:P0DTC8"}
{"id":"f751b5be-0168-45c0-82ce-bf48584734fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:78XZC39FR5","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:998f5b8d-2439-49f0-a198-dfd8e5643f73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3167","original_object":"UniProtKB:P14324"}
{"id":"f9c97c99-44c8-4c29-afed-d768341a1645","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25150700","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:7d32d00a-cdee-4dad-a87c-700edb04e920","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1201","original_object":"UniProtKB:P35367"}
{"id":"8c587c08-5492-4613-9503-4b796477fa4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:d5e6abdc-1ea1-4a4a-b1df-c1cf19e83e91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P11362"}
{"id":"98094086-2045-453a-8a29-684f58874617","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:5d7c38e8-8d42-40dd-bb7d-38d46dca3d2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8593","original_object":"UniProtKB:P11229"}
{"id":"b18187ff-ac31-43ab-b9b4-05bc855b2df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137746","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:558d2853-de7e-468f-bcde-e675a8eb2519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6167","original_object":"UniProtKB:Q8TDS5"}
{"id":"b678fbd3-1618-4634-b128-679ede9596bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167638","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:543eacbf-e50c-4275-9667-ed491f4eb38d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7207","original_object":"UniProtKB:P07550"}
{"id":"ddc07813-8185-46cd-b448-776f5ab7a5fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31515","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:979abc3b-1414-4087-a237-fdd6c24910ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:965","original_object":"UniProtKB:P14416"}
{"id":"073aa4da-a385-49a5-b631-17e3f74fe15d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566764","predicate":"biolink:affects","object":"NCBIGene:10039","sources":[{"id":"urn:uuid:1a5d4e3b-45e0-42ef-8f31-0f8cb2ee2148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8468","original_object":"UniProtKB:Q9Y6F1"}
{"id":"f6ce232c-d59e-442c-9568-203fe82a5e49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5261","predicate":"biolink:affects","object":"NCBIGene:5592","sources":[{"id":"urn:uuid:5be70c67-45e6-43e2-b51d-cf7d3ca8426e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5261","original_object":"UniProtKB:Q13976"}
{"id":"d29a1bc1-c862-4cb9-9adf-82d0eb032ee1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155884469","predicate":"biolink:affects","object":"NCBIGene:5305","sources":[{"id":"urn:uuid:a7fbd434-32b5-464f-a422-a57d1df9d17f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11794","original_object":"UniProtKB:P48426"}
{"id":"4e2350e8-9de6-47cc-ba28-3465a2e36420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12942","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:b23fd6fc-5383-4067-9f80-a2522bd0adef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12942","original_object":"UniProtKB:Q86TI2"}
{"id":"a1125b45-9073-4ea9-8a41-68d73502ba55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9757","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:f3554450-230c-47a8-b1a1-bba99e20931e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7319","original_object":"UniProtKB:P08173"}
{"id":"3ee1fcf0-5929-41e1-9b6c-05e38702896b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3789","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:43094eb6-edd9-4853-9dba-6e0f9a421bca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3789","original_object":"UniProtKB:Q8TDU9"}
{"id":"dab5ea15-0c02-4cd2-a4f1-2f039e5d5aed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92667","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:dbd4bdd5-b7c3-49d2-878b-a67bd7456513","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:448","original_object":"UniProtKB:P29275"}
{"id":"2760d259-9648-4867-b37f-23b903dbffd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FOF5155FMZ","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:047d7464-64ae-419d-a032-02341e86c811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9563","original_object":"UniProtKB:O00329"}
{"id":"20431067-ab5d-4bc7-adef-e7419206b8c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:47DD4548PB","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:498fc389-86a1-4e7a-9174-6c4bbe499003","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9248","original_object":"UniProtKB:P00533"}
{"id":"c4f6f1ea-50ce-4d0f-9f9c-b962451fbcce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1085108","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:bfcae169-7a17-4eae-939d-ff7f4224eba3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8227","original_object":"UniProtKB:P14902"}
{"id":"335b2821-b33b-46ef-9e0d-0aea277451bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156907317","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:2acb65e8-deec-419b-83e2-b1b24146b2a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11765","original_object":"UniProtKB:P0DTC1"}
{"id":"7cf20571-e3e6-4542-ab96-d4d7a002bac2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:8aa7cee7-4926-4442-b04b-77a2105c7953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P06493"}
{"id":"9e073618-491c-411e-9a33-f490b7249542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75947","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:d3cd5658-999f-4e56-a712-867ba7c91932","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9207","original_object":"UniProtKB:Q86WV6"}
{"id":"9cae74bf-497f-463a-9ada-83b725e9e33d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95033","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:01b9248a-267c-4d47-92ef-fcaa7508168b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9130","original_object":"UniProtKB:P04049"}
{"id":"f4dc2242-8be9-4887-81ad-9f51f465cd03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92950","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:e834613a-b7b7-4a5b-a5b8-081a0ad5fbbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:515","original_object":"UniProtKB:P23944"}
{"id":"da8af0a0-d946-410f-b834-a97a0ffc1030","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9690136","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:cfb6ce28-d1b0-4fbd-b229-f110d9d05f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2192","original_object":"UniProtKB:P30559"}
{"id":"0022d771-68fb-455a-b07b-c2220da07d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92490","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:98ab08ce-6d63-42ce-ae61-62c7287f34e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1860","original_object":"UniProtKB:P25105"}
{"id":"7894e1e1-a4f8-4e39-ae3e-79225b7e5e51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2072","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:c8dbeaef-2a8c-4a5f-bbbe-8d93a479d331","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2072","original_object":"UniProtKB:P30935"}
{"id":"ed845653-1fa5-4cb1-bf3b-6dbd231e9540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162718203","predicate":"biolink:affects","object":"NCBIGene:6502","sources":[{"id":"urn:uuid:1bfd2985-4848-42da-9c6f-d76121a8b5ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12746","original_object":"UniProtKB:Q13309"}
{"id":"f05023f1-069d-4e96-9553-34fadcc81b90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4283353","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:bfce6226-2f40-4207-914f-1532819ea409","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10131","original_object":"UniProtKB:P36888"}
{"id":"d10dc88e-9ada-4d82-8a83-a82999a41584","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17489","predicate":"biolink:affects","object":"NCBIGene:1261","sources":[{"id":"urn:uuid:ee8d4aaf-3330-451a-b21d-5274606755f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2352","original_object":"UniProtKB:Q16281"}
{"id":"8b021b60-ab00-4a6f-912b-8bb36d6de868","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93046","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:fdd406bd-ec92-45fc-8869-17456880fce8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5392","original_object":"UniProtKB:P23385"}
{"id":"ae4534c0-9004-4e1c-b6ba-22ec9f541a1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZL7A1UM87X","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:9b3bc660-ddb0-40a2-8d8a-a424e075f028","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10908","original_object":"UniProtKB:P31751"}
{"id":"a962709c-a02f-4ada-a4b2-e7f7c439793a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28927","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:54d42303-57ea-4244-b0a0-eb24b8cf930a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:412","original_object":"UniProtKB:P59538"}
{"id":"36b6ef52-3271-4bb5-8ef1-67cb7ec1ea7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:56eb1998-a42b-4bad-b7d9-da4c73bb6459","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P31388"}
{"id":"38a2522d-7e59-426d-9404-9e7d2610c3c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135697","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:93d3e6d1-81c4-4a29-995a-aa5609a94c30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:210","original_object":"UniProtKB:P41595"}
{"id":"2433a4b2-e2b3-4dc9-82ac-8dd5b51860d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125354","predicate":"biolink:affects","object":"NCBIGene:57007","sources":[{"id":"urn:uuid:2ed7bfad-1f40-486f-bd68-1bc2a51ef1d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:844","original_object":"UniProtKB:P25106"}
{"id":"8b5a55d5-e05c-4623-8ba2-dff616ba77bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7457","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:d490b100-c8f9-417a-b081-97d390a026b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1628","original_object":"UniProtKB:P35372"}
{"id":"6709dcc5-e6e2-44d7-a7bc-6d70931333ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:10ef5f6f-ff90-4bd9-9cea-d4dbf5456784","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P0DMS8"}
{"id":"cdadea0c-d9a3-4628-9804-19c91b3bf940","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180525","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:983e5faf-1811-4fcf-9bc4-789b7bd81aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:417","original_object":"UniProtKB:P29274"}
{"id":"670a9313-ce94-4d57-af0d-a42f306fbe93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:4b6c7118-54b0-4950-9402-0103e05c60d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P15387"}
{"id":"ff208e09-38cd-4185-8850-acac206199b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4549658","predicate":"biolink:affects","object":"NCBIGene:3795","sources":[{"id":"urn:uuid:afb0fc7c-4bca-4e9b-a846-a593eba7cab8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12748","original_object":"UniProtKB:P50053"}
{"id":"f09ce746-e494-45d7-8e11-9fea26faadd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072547","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:c1a36d49-1ca5-46ba-9155-1da8d5612a9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8936","original_object":"UniProtKB:Q13153"}
{"id":"842f9860-bf6c-42c1-8cc5-3185eaf465c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5E7RR1J6TR","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:5659c6b8-f2eb-4ee6-9d1c-96ff78c18168","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10336","original_object":"UniProtKB:P57789"}
{"id":"0c81d0f5-42c7-4a4d-a564-6ac08fde5379","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132471","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:b84b891c-1cf6-471e-b07c-cabea5506c4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13774","original_object":"UniProtKB:P49841"}
{"id":"6aa31f32-f0bd-4318-b18f-fed1b094bf97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:25187","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:e6f9dce2-98b3-47c9-8722-99efb2649df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2430","original_object":"UniProtKB:Q8K424"}
{"id":"e96762cb-b7a2-4c2b-a8fa-552f448447bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232381","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:ad6ff493-afff-49f9-b189-d3df47ad723e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9355","original_object":"UniProtKB:P53779"}
{"id":"28b005f8-0d8f-4a86-a705-ce1058b3d894","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1795545","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:7497c175-b861-4869-969e-2f35f3554485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1414","original_object":"UniProtKB:P31423"}
{"id":"20c95216-1354-4937-afd0-b4df391c8968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:f8c2efb0-15ec-4216-920b-ad244812b54c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P35916"}
{"id":"0f2170d7-de40-40ed-b676-fedde776076f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1759677","predicate":"biolink:affects","object":"NCBIGene:214763","sources":[{"id":"urn:uuid:7526ce49-2726-4568-a879-6b67d81576d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13077","original_object":"UniProtKB:Q8C6L5"}
{"id":"d472a852-cef1-4b4b-be57-da44cad82226","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43580","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:3764c031-1216-4d5f-9d41-13881d969a4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4709","original_object":"UniProtKB:Q7Z2H8"}
{"id":"4347ee8e-9416-410f-aaec-e9a58c217fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2742550","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:3332afe9-e3c7-4866-8a77-ab371243a35b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4213","original_object":"UniProtKB:Q9HBA0"}
{"id":"388d31ea-f29d-4f5d-bb77-ebc410ad6966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3849","predicate":"biolink:affects","object":"NCBIGene:24807","sources":[{"id":"urn:uuid:6cb6c0d3-c2b4-43bd-be73-00de6039ee1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3849","original_object":"UniProtKB:P14600"}
{"id":"671d1c93-bc60-49f0-b000-d1b5ab05bfec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656733","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:ff4d0cc1-7086-4150-9e23-669d856ba3b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2320","original_object":"UniProtKB:Q9UGI6"}
{"id":"7831957a-29e3-48ee-95c0-caa1cfeb5aa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:24613","sources":[{"id":"urn:uuid:22119770-f88f-45f7-be2d-39679a15e03a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3829","original_object":"UniProtKB:P33533"}
{"id":"0c13f316-9ca3-45d2-b52e-e4ee629eaf09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603801","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:3b0a0a39-bfde-4a36-9c81-25587c8b4ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:153","original_object":"UniProtKB:P28335"}
{"id":"b5d615d1-13dd-42bb-ad05-a0bd0f57118a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D65H9YE9VU","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:dbd317b5-2c94-46c7-a5c0-9c21f555cdbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8985","original_object":"UniProtKB:Q9Y5N1"}
{"id":"e9708369-a6fa-4300-a87b-3d342d8aa911","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95129","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:08642dd7-de79-4309-ab08-cd64f4ec044e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:240","original_object":"UniProtKB:P32304"}
{"id":"9f3d2dfc-b333-436e-9fbb-1b7bd0d34a72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9796720","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:e1338a0b-0720-4623-a376-6c7c3cb09609","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:973","original_object":"UniProtKB:P30729"}
{"id":"9f0bb5ee-b51a-4593-a256-d5aa7e12056a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45258277","predicate":"biolink:affects","object":"NCBIGene:5587","sources":[{"id":"urn:uuid:ef3185f5-82db-4aae-8485-ff7c7739f707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9369","original_object":"UniProtKB:Q15139"}
{"id":"3fd91443-1f33-4095-ad99-c3a8f37e19cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5931","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:caa04f32-94ee-4d30-b4e7-edb8ffa5bee7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5012","original_object":"UniProtKB:P06213"}
{"id":"4aa8b149-165d-4acf-a54b-e23cb243eed2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:931L4X5WMM","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:bda08f2c-a884-40d2-8750-4d09160b954b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1226","original_object":"UniProtKB:Q9Y5N1"}
{"id":"dc826dca-a8d4-4558-b449-f8c84ebf8948","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95087","predicate":"biolink:affects","object":"NCBIGene:22992","sources":[{"id":"urn:uuid:ca86faec-ea79-4f4d-8ff3-bb44275ae7e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8229","original_object":"UniProtKB:Q9Y2K7"}
{"id":"56d86901-e3e3-4d3f-9113-22fda1143b2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154663238","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:beae906e-8ecc-4025-a2b8-8ccf868fc594","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12112","original_object":"UniProtKB:P31749"}
{"id":"73959f6a-f2ed-4938-b995-77e8174754e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66561167","predicate":"biolink:affects","object":"NCBIGene:9451","sources":[{"id":"urn:uuid:e721c1fd-0dcd-4313-906d-aea9aecfa04d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6740","original_object":"UniProtKB:Q9NZJ5"}
{"id":"9b645d16-e009-4f24-9a36-460db4bec007","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13579","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:1c6198a2-ab3e-4557-9f05-da14679df4c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13579","original_object":"UniProtKB:P30530"}
{"id":"c35c83de-2152-4e8c-8dfa-ca47008fb21e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:4d8ef9cb-21a1-4190-9fab-531b752ed79e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:Q9BY41"}
{"id":"878f2d98-f23c-4cf0-b4fb-1ec1abd8656d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44299731","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:e441cb09-a19c-426d-9dac-a1621b50f0c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:585","original_object":"UniProtKB:P30556"}
{"id":"26e12a13-224f-4e34-9f11-9991c1616a2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3061","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:78b18ec9-30aa-4f4e-a580-92b18f215a69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2337","original_object":"UniProtKB:P56696"}
{"id":"4bcf4116-3be8-4fa0-a9b9-b9ed437d8657","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3084","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:7c3a6e2d-eaa1-4a63-bd60-854431655ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:297","original_object":"UniProtKB:P08912"}
{"id":"12afb2ec-9d23-4d03-b31f-08f758ad319f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5288811","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:7f1c0047-73a5-43e5-b9dc-798dfb5ad651","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3980","original_object":"UniProtKB:Q9GZZ6"}
{"id":"111e4676-a7ae-4128-b5d4-230cc3b90c8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:b4bc6392-9694-40c1-b917-2fb03a3f3dd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P30557"}
{"id":"4963e321-8ca7-4851-a08c-177110388b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129928","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:603e7fcf-0b2b-4cd0-8a51-b8bcb010626b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:246","original_object":"UniProtKB:Q13639"}
{"id":"794a01df-1fd6-46b9-b0d5-adde7582f49e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2079","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:99ac1e47-3947-48c6-81a0-ab4fa36dffaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2079","original_object":"UniProtKB:P31391"}
{"id":"842e4079-28ee-434f-aa39-3d9a17b3b8d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:681","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:a0558ee3-92da-4c57-a977-d63ea3e92a02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:681","original_object":"UniProtKB:P30988"}
{"id":"4c454ce1-3cf0-4a82-a500-e7ba54beb10b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2038","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:bdc4f6ab-3738-4718-81ef-252c3efa76ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2038","original_object":"UniProtKB:P35346"}
{"id":"b9f398fd-2390-423c-8c3e-97cd14a60fe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3723","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:18b6d372-c1da-4c77-99f3-90532a0e6117","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7547","original_object":"UniProtKB:P31645"}
{"id":"6c092bcd-0894-489a-b642-275a46d488f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR9ZYH80Z8","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:8355d94b-1527-440c-ba82-f50a12d6b4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9787","original_object":"UniProtKB:P09619"}
{"id":"dd1f436a-e7d7-4acf-8253-a4d16af88e6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593559","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:62d67357-45cb-44cb-b4cf-2099309b668c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10518","original_object":"UniProtKB:P35372"}
{"id":"455dad61-bcbe-4f1f-9a09-8f1d5b0d32c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177624","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:01811e56-14af-4bab-8513-92f423238403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4035","original_object":"UniProtKB:O43193"}
{"id":"886b1409-9f97-458c-9237-e4298068678d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47097","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:68d9ac88-dcc8-4b7b-8300-b76c0bfe8ac0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8024","original_object":"UniProtKB:P01116"}
{"id":"71f5ee68-bba4-4cfc-a7c3-92aa4bb32d04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:5332992a-4507-4f2b-a552-bb457ace34aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P28223"}
{"id":"981976a3-3b1a-41a5-8dff-211608b4cf98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17027464","predicate":"biolink:affects","object":"NCBIGene:50507","sources":[{"id":"urn:uuid:9541d5f6-a7d3-4196-816f-1141582fe672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9935","original_object":"UniProtKB:Q9NPH5"}
{"id":"b9127eb1-47df-4a7b-8e43-930a9e0f638c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5558","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:a9cfea1a-01a0-489e-a030-ccf28785437b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:522","original_object":"UniProtKB:P08913"}
{"id":"e9e4508d-1642-4da3-b79c-4b8d2ff92eef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72164440","predicate":"biolink:affects","object":"NCBIGene:23031","sources":[{"id":"urn:uuid:b69ccd81-9537-44c5-8676-b12c26481535","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8842","original_object":"UniProtKB:O60307"}
{"id":"dfd9e634-10ae-4d27-b4a8-28f2dc5ac695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3213","predicate":"biolink:affects","object":"NCBIGene:6557","sources":[{"id":"urn:uuid:ae29b837-59f4-4055-abef-76636f717c95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4837","original_object":"UniProtKB:Q13621"}
{"id":"2a319a18-fc87-4434-ab0f-3ae829285a77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12844","predicate":"biolink:affects","object":"NCBIGene:389400","sources":[{"id":"urn:uuid:99fc3ad8-987d-4a31-9acc-a683a4baabd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12844","original_object":"UniProtKB:Q6UXV0"}
{"id":"18a908cc-47ce-409d-bb0d-949a992981b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140980","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:8fae3e0a-cb87-4393-99d2-ed5c77e31667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1486","original_object":"UniProtKB:Q9Y5X5"}
{"id":"13fdfa04-0661-472d-92f4-a586da2a7b9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755254","predicate":"biolink:affects","object":"NCBIGene:13609","sources":[{"id":"urn:uuid:86b884f3-dcd6-4b36-9558-90d2842b808a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6992","original_object":"UniProtKB:O08530"}
{"id":"065c3040-2389-41d0-b2f9-88a0e6fe4a85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95340","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:df070ae6-6d47-4770-acca-c63b51c519e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11064","original_object":"UniProtKB:P06493"}
{"id":"46f2d9c6-2ba7-48b6-a1f5-bada60ca782c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:57J06X6EI0","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:d8af568b-3b0a-445f-8130-032ea6ae9bdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10654","original_object":"UniProtKB:P31639"}
{"id":"260fbfef-153f-42c9-a69c-9bf623468108","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57889181","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:c7798f2c-4b62-49a0-8f71-e594a46ee8f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9497","original_object":"UniProtKB:P32246"}
{"id":"3f278404-b7c7-468d-bedc-36ef3c0723cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699450","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:260d8914-43da-4fd0-9997-864918a55f5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11147","original_object":"UniProtKB:Q9NRA0"}
{"id":"e21050f9-9d6b-4b0e-8cf6-e331db40922d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:342b2f4d-c887-4bff-b8ca-78d56cedd515","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P47900"}
{"id":"941132a5-cffc-46ed-a828-0396c0f795a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75W6I8W6OU","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:fe9b632e-9f85-458d-8ec3-0ab0fc0b915b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4249","original_object":"UniProtKB:P42262"}
{"id":"f3c5c903-4421-4f45-bc66-fcb01bc1a8d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10078814","predicate":"biolink:affects","object":"NCBIGene:5222","sources":[{"id":"urn:uuid:31f56d3c-5e6b-4d8a-93fe-76c5cd589540","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8634","original_object":"UniProtKB:P0DJD9"}
{"id":"80b45a17-a2e2-49a0-be52-3287c84bfb98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:53f1bd02-f4cc-4996-a797-4befc4f7589c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P32745"}
{"id":"c6bb1083-1618-46ec-b1c1-9717839b778b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B57Z82EOGE","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:81a6226f-d855-42fb-855b-a8ed3c69211f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:120","original_object":"UniProtKB:P28221"}
{"id":"68fa8852-0013-4752-a0a6-1da0eeca8e82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103854","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:f83a1f7a-546f-4b2a-9315-7ec41e75d3f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:480","original_object":"UniProtKB:P35368"}
{"id":"e3a5cc3c-3143-45c6-a3ea-deda4804c51d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:16fbeb5c-0227-486e-98cc-6e1197b0f84e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:O43603"}
{"id":"51464f86-fa07-4015-b9df-c13f27fc26a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:3b564c33-2486-4033-b35a-73a242c684a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:Q5S007"}
{"id":"713bf41a-be53-41f0-8b9c-f28d4d87dbfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7445","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:4321f32a-63e1-4a4f-aec1-afb34f24b391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3902","original_object":"UniProtKB:P30968"}
{"id":"9cd93abb-fe48-4dba-8e87-04b5627c64a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76283388","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:86887a10-6376-40a3-a07d-6badf4a96c4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13442","original_object":"UniProtKB:P35368"}
{"id":"c0d071fb-0e38-4b24-b8d7-c3cd39480ac6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37850","predicate":"biolink:affects","object":"NCBIGene:3710","sources":[{"id":"urn:uuid:d622439c-7f42-45f8-91f6-f12963a525b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2459","original_object":"UniProtKB:Q14573"}
{"id":"8d37b5e0-1731-4da0-80c4-fe7fabe903db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129140","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:4db553c1-cdfc-42a1-b5e2-89aaf16b06c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8583","original_object":"UniProtKB:P08173"}
{"id":"92d531e4-07db-4888-81c4-21efe3a5baf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:e4965214-3569-4b74-97ec-c53d901c6c2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2291","original_object":"UniProtKB:P23415"}
{"id":"f914d3f8-efe8-4bf8-a24d-b8ee3e56d24a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5841","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:067ac35e-062e-416f-bbd5-efc6467045f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5841","original_object":"UniProtKB:O88536"}
{"id":"2fc02747-8bea-4f26-b258-bd190ca5babb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:81025","sources":[{"id":"urn:uuid:d48c855e-80d2-4e30-aa04-1332322d8030","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P57773"}
{"id":"fde95a46-a2ff-4db6-9594-ac810d8e9f16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10046145","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:3f3947f5-6af3-49f8-ba45-f87814afbc96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5610","original_object":"UniProtKB:P29274"}
{"id":"e4acad4c-dc59-412c-83ff-ec5a7920a24c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183839","predicate":"biolink:affects","object":"UniProtKB:Q00910","sources":[{"id":"urn:uuid:22c1030e-6cc1-4c0d-98eb-6c852da24283","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4530","original_object":"UniProtKB:Q00910"}
{"id":"96d08254-d7f4-4752-9e9e-e92c6d39dec6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5H2QQ669K9","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:149e3aaa-56d0-4cc6-bc80-777be7508e64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6253","original_object":"UniProtKB:Q14416"}
{"id":"f2759775-5268-40a9-bf39-895a813c1d9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81529","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:b890295e-b4ce-4324-bc01-6135c54e9603","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1642","original_object":"UniProtKB:P35372"}
{"id":"0066dce0-fd54-47de-8d94-08d9c45d215a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:83795","sources":[{"id":"urn:uuid:e58bf0e2-03ef-48fb-a165-3a0dc3cb2f61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2344","original_object":"UniProtKB:Q96T55"}
{"id":"59613c97-ed02-4242-b053-14371b54af3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4028","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:7a5537bd-334b-4caa-bb93-642a4878c08b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4028","original_object":"UniProtKB:Q9Y2T6"}
{"id":"31ccb1bf-0ba2-44da-8bf5-316baccbf2b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11824289","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:79c9df22-9c90-48cc-b40d-443516c0f8a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4094","original_object":"UniProtKB:P14867"}
{"id":"e078902a-3837-4794-b73c-7025ae6d0741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9969021","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:8f389150-7f06-4e93-a114-35a2dc399058","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5954","original_object":"UniProtKB:O96017"}
{"id":"9ea08907-1804-4ba4-848a-f1b7dfe9f52e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31785","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:7afe9734-5c37-402f-9472-6365b526f93c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:892","original_object":"UniProtKB:P30551"}
{"id":"60d7028e-0fad-4adb-b942-5bbcd98e64fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:23046","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:97def801-dbe4-4408-b23e-a008a6660ca1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6417","original_object":"UniProtKB:Q8K424"}
{"id":"10a125c4-8259-4bb7-b1ad-a675fb5117d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16094751","predicate":"biolink:affects","object":"NCBIGene:7052","sources":[{"id":"urn:uuid:41a46794-67e6-4e1a-bbc9-cd21fa100007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10048","original_object":"UniProtKB:P21980"}
{"id":"20e6bd24-b7c4-437b-ac98-3956cdce6e9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1165","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:840faa83-c221-4dc9-beb3-a0835db8bcb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1165","original_object":"UniProtKB:P30968"}
{"id":"0326a2a8-2b0c-4189-8c8d-a76d1ee4a5df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3699","predicate":"biolink:affects","object":"NCBIGene:55244","sources":[{"id":"urn:uuid:a8116f50-c8cb-4c21-b33a-32ddbbb502f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1231","original_object":"UniProtKB:Q96FL8"}
{"id":"0929fa72-a607-4bf0-bc74-7b7c05fd1dfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:8444","sources":[{"id":"urn:uuid:460dda98-f716-4992-ae99-af159d5c7519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:O43781"}
{"id":"b89ad7fe-0516-49a1-bdcb-bf24617e1c92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3074331","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:7c569ccc-eed2-4f0d-86aa-55abb7e1392b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:872","original_object":"UniProtKB:P30551"}
{"id":"2fe8269e-2b68-40a3-a72b-8af47dc9d44b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M43ZDU10DD","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:33c0ce63-a815-45b6-92cb-e8468a66f192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12110","original_object":"UniProtKB:P48067"}
{"id":"d81ab6f8-5c52-4a6f-9147-aa9ca17318b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803242","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:39fbfd41-e86e-4359-890b-26038b57676e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8905","original_object":"UniProtKB:P19793"}
{"id":"825eddad-264f-4a78-9485-90a107a8472b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53494934","predicate":"biolink:affects","object":"NCBIGene:16790","sources":[{"id":"urn:uuid:921f884d-7d59-4da8-8987-6cbd2845178c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8565","original_object":"UniProtKB:P97449"}
{"id":"669972f3-b003-45e9-ac37-3b6b83536c62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93074","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:a2538ec8-76c7-4795-92e2-d99617e34430","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:833","original_object":"UniProtKB:P25025"}
{"id":"939d8d59-c939-4036-8360-1e6b80df3637","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54726845","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:08fadf68-c392-49e2-8bf0-9c52c494983a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4072","original_object":"UniProtKB:O75311"}
{"id":"7d0b0688-04d7-49f9-8cc1-5056e7013826","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53318931","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:862ea18c-f173-4c7e-beaf-732eb6a70004","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9612","original_object":"UniProtKB:P21554"}
{"id":"3e4f7d98-82f0-4921-b4a8-ec0a6b2793a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:c49ee248-d1f8-45a9-af20-04012eccf6ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P30966"}
{"id":"f90b381c-9b02-46eb-b5f7-8bee249ceff4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:9a873b4a-bc79-4dc0-82f4-31122138a18b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P28223"}
{"id":"0ec4d12f-e5f3-4485-990b-54c9e575dbdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1794","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:3c6b757a-4148-40d4-bdda-012ca910c235","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1794","original_object":"UniProtKB:P49190"}
{"id":"af4d456e-2159-4bc4-a573-c61ec94ba1e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:039c7b4a-8a0c-4bfa-a650-f41c0cbd5f7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P28223"}
{"id":"42d8ece7-3753-4592-927f-f6ee47886f03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64069","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:1ca0edf2-55ef-4460-ba05-e5927fd6ead8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:130","original_object":"UniProtKB:P28335"}
{"id":"ffb0dd9c-2011-4485-844e-c57afb1f90dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280454","predicate":"biolink:affects","object":"NCBIGene:5163","sources":[{"id":"urn:uuid:d1f1a202-9a55-4dd1-b946-798ccb622487","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9350","original_object":"UniProtKB:Q15118"}
{"id":"e521901b-fd43-469e-ba6e-613b0e9856a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:764","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:6c5e723e-5361-44da-9e82-55cc52e5d6f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:764","original_object":"UniProtKB:P32246"}
{"id":"1c50a9af-014e-4054-958f-29089198fc64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185787","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:2e5c93aa-9695-43e4-8aa5-3304550fc098","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9706","original_object":"UniProtKB:P21554"}
{"id":"767731ac-efd6-442a-bb59-c12130783af4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:658","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:4601a9ca-8758-4620-bd15-5dd229499a97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:658","original_object":"UniProtKB:P46663"}
{"id":"f3c3f9d6-fbaa-463b-b71b-a02f01e8e88d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137701512","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:06d6cfeb-e901-416a-91b0-4b741c935a69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10673","original_object":"UniProtKB:O95271"}
{"id":"0bd0454a-f422-46f4-945b-5f80bcfd58f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155289267","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:9a47afb5-c7b1-42b0-8c05-f6f6ede938bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11472","original_object":"UniProtKB:P78348"}
{"id":"8739e66e-c2ef-4725-9755-22eb6e69112f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167672","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:0e895de0-6cbc-4671-ac8e-667056e4a362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9977","original_object":"UniProtKB:P15056"}
{"id":"5c6a7135-1556-42b1-82c1-d4dc5eca6ec3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145431","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:8d519c52-0152-4c0a-baae-55111fadaece","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7046","original_object":"UniProtKB:P00915"}
{"id":"6ee1c351-3c29-4b9f-9605-a37e21b5cd0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q77EAZ9TG9","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:6dfe80c3-a990-4d32-80f0-a2ec59170898","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8434","original_object":"UniProtKB:P28223"}
{"id":"606f67ae-71b8-4ffd-be06-7ee1607e85e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:2e6fe993-7dd9-4c42-9ea2-94933a596b63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P70579"}
{"id":"8933d838-45d5-434d-91d3-d3c7e7c00819","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K41YC3AEI8","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:0a11aa1e-260b-4958-ab8f-801fa6a96131","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1622","original_object":"UniProtKB:P34975"}
{"id":"d2885ab7-de0e-444b-a57c-06fb39a75983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:66fee355-d09d-4c49-9582-97141e9cb8d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P14842"}
{"id":"21f3414c-e2bd-4e54-8f6d-7d737da32218","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95082","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:131f418c-61d4-4319-bd14-04293fa0e93a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7033","original_object":"UniProtKB:Q15059"}
{"id":"a1abee84-70c7-4372-97c5-a9f6e05758ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:a5a7fc86-8ee1-4205-bfdf-2dd1c543e850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P28566"}
{"id":"0c7c7b56-929d-4a79-845b-714cdaad6c2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GGK40O1O85","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:78962bd8-3aff-47dc-9a95-9f459c244ef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9812","original_object":"UniProtKB:P04150"}
{"id":"d59c1b7c-7ecc-43f8-a1f2-4b33fafc9b90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67SX9H68W2","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:f30ca10e-2e9d-487b-a344-b50492354077","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10456","original_object":"UniProtKB:Q12809"}
{"id":"2581852f-3079-4ce4-a84b-26524ff91204","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13576","predicate":"biolink:affects","object":"NCBIGene:5137","sources":[{"id":"urn:uuid:9a23443d-9c1b-49eb-be3a-ebab9930396d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13576","original_object":"UniProtKB:Q14123"}
{"id":"ef3ef0f7-63ad-4cc2-a694-0a175533d196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2276","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:e3457ae2-bd90-4552-afd5-6fbf4b3721f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2276","original_object":"UniProtKB:P32241"}
{"id":"73fac22d-11f0-4d21-9c1c-f80939134799","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:2046","sources":[{"id":"urn:uuid:3f4fad13-b47e-44ec-9331-333947259844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:P29322"}
{"id":"9f2f47ee-8bb7-4f8b-a702-1c42d3e9fd95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030521","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:f0451a2a-b162-4aa2-ae6a-39d7f2ccd1d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10435","original_object":"UniProtKB:Q9NYK1"}
{"id":"f06ad04a-a3d6-4108-9fa3-d874faaecc4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71466","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:66c69a82-5971-4428-bd51-1862b10f32d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2661","original_object":"UniProtKB:Q8TDV5"}
{"id":"e97d262e-dcb1-496a-88ef-13335dae4d0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101615586","predicate":"biolink:affects","object":"NCBIGene:1544","sources":[{"id":"urn:uuid:4ea3c9ca-0ed9-4ed6-a198-fee7b49cfb51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13592","original_object":"UniProtKB:P05177"}
{"id":"a7bba2cf-b8e2-4c9f-8cb8-30f5221a9fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27882","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:04980db1-ca1d-4c56-b7ae-f5cf71079e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2367","original_object":"UniProtKB:P23416"}
{"id":"ede79961-a701-4855-a167-54c14ec96af0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168057","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:e93e27df-e077-437b-ad42-842c7897e582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7634","original_object":"UniProtKB:P08172"}
{"id":"4668037a-d47c-4816-96b5-4df35de441f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1567","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:87195c7d-51a4-4da7-9488-fd4763d98dae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1567","original_object":"UniProtKB:P20789"}
{"id":"7e5aab5d-a570-4a65-8a65-65969c914e81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153379950","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:7e5e6510-854c-4ee4-afcc-ed80627419a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12884","original_object":"UniProtKB:P18031"}
{"id":"cd20f355-a642-4101-bd4d-ab4ea7a880e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75728","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:449c0a1d-a9dd-4576-a7ad-1a3d99d669b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2437","original_object":"UniProtKB:Q9Y210"}
{"id":"efd38b04-71e3-4a0e-9fb7-7b02841ed78d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437074","predicate":"biolink:affects","object":"NCBIGene:24816","sources":[{"id":"urn:uuid:0f2883b0-0744-4448-903e-948bfe6470d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1985","original_object":"UniProtKB:P34978"}
{"id":"a68421d1-1744-4b81-b140-410636c8c097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:169004","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:25e5656d-d550-4dd8-9920-089c6ec992c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2474","original_object":"UniProtKB:Q8R4D5"}
{"id":"0df8b4fe-f356-40b3-9b05-8c320993f43e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S25VDY08ZC","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:8aa3b51d-6b32-4d82-bc54-549ff923244d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1986","original_object":"UniProtKB:P21731"}
{"id":"2e53c8e6-4a9c-4186-874f-313a1a6b3943","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15854","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:80c28f46-b31f-42c4-82e5-205c5d831995","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2510","original_object":"UniProtKB:Q9NYV8"}
{"id":"53310b28-343b-4908-ad2b-5d2e9f21bd7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:44B1597K8X","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:84a972c6-cf76-4b6f-aa02-f89d70b64e60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3218","original_object":"UniProtKB:P08908"}
{"id":"fe5db8e7-bc2f-4399-812f-bb5d7100dc0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80312","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:1e9f0c0d-4299-477c-956c-7065e3840f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2090","original_object":"UniProtKB:P29371"}
{"id":"f729a115-e999-4e04-9b83-4e676d5c6a10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2040","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:32e0c095-4a54-4908-b848-8bf1efe4217a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2040","original_object":"UniProtKB:P30875"}
{"id":"2969f64e-9674-4009-8c0f-7ebc19f13b16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:fdfb86f3-e516-4d1c-90e8-d7408533fbd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28221"}
{"id":"dab107d7-24c9-4716-a53a-3d866b5dbfa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135418373","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:8ebdce47-13fc-4d2e-91a1-9e4a5f5702cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4052","original_object":"UniProtKB:P03372"}
{"id":"9c3ffb5e-02b5-4759-ae3b-c67e056f46b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44571034","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:063a5328-af24-4598-9631-63e468232699","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7036","original_object":"UniProtKB:Q09472"}
{"id":"a7aec264-994c-49cc-94ad-15869717e2b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2158753C7E","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:5f2bf5ef-ef4f-45ef-a3b5-f1b3a4075a32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13830","original_object":"UniProtKB:P04150"}
{"id":"7049df85-9812-44e7-b2d5-5f02de9ad09d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993635","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:ba94a118-01a2-4f4f-9fd9-ff81bcefdf59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12334","original_object":"UniProtKB:P35916"}
{"id":"8d661a6b-ab98-4748-94cd-84cf718b62de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17757220","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:5454b10e-b65b-4549-9da3-5f8a1bdec2dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6982","original_object":"UniProtKB:Q9JL06"}
{"id":"f7e9428b-176f-4e25-b4d5-af7623e0fa7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:157040072","predicate":"biolink:affects","object":"NCBIGene:5167","sources":[{"id":"urn:uuid:3db0de97-e570-421c-98c8-71d639e2dfaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13938","original_object":"UniProtKB:P22413"}
{"id":"f06ad921-62ca-4285-82ea-bee64246f4e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4X2F5X24UK","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:79a6589c-97a3-40be-870a-5f7740ed1159","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1432","original_object":"UniProtKB:Q14833"}
{"id":"9794208f-6679-421d-8077-80804b18d3fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:3770","sources":[{"id":"urn:uuid:b05bda90-17cd-435a-bb43-93b8226daf2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:Q9UNX9"}
{"id":"83ecce8f-832a-427c-8430-3a74f9190873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:8be2957c-26ba-4a09-8955-2b7f9800795c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:Q16620"}
{"id":"8b58c098-af36-40af-8b73-1bc72b317d98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4461486f-20bb-4c10-9b55-473eb0d368d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:P0DMS8"}
{"id":"c082a7df-2ca6-4e45-97d2-04ed21a548b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28346","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:7cd240d1-8ee7-4897-a9ff-471883facbee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13139","original_object":"UniProtKB:P28223"}
{"id":"282195b1-6688-482b-b719-09d5e0faa4a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139399801","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:c36b90fe-a2d3-4032-a951-78f7abb0fdc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13694","original_object":"UniProtKB:P13569"}
{"id":"dabd4b2b-8c42-422c-87fa-b4cdc5dff5a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90545","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:2e7d5504-2d38-49cf-b54b-843d99fb4e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7965","original_object":"UniProtKB:P42336"}
{"id":"7be9036f-782e-404b-bb3c-499b172c41df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9985","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:8dcdc539-0d8c-404e-8380-3916daa1485b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:349","original_object":"UniProtKB:P20309"}
{"id":"e719d660-7088-4ca0-994e-d9ed917f77e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1695","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:0e0344fd-4118-409f-8987-4b5cb3808b59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1695","original_object":"UniProtKB:P41146"}
{"id":"70aacd30-da94-43d3-8927-b67a46e70b40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:961606","predicate":"biolink:affects","object":"NCBIGene:4929","sources":[{"id":"urn:uuid:93654f57-8bd0-4c84-9d04-7d8f00687af9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12997","original_object":"UniProtKB:P43354"}
{"id":"e7e4f2fa-4eb7-43bc-96ac-b78f92deab67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O4BT6C02M2","predicate":"biolink:affects","object":"NCBIGene:16912","sources":[{"id":"urn:uuid:e84d1df2-909e-4e4c-bd0c-701785d81c8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10409","original_object":"UniProtKB:P28076"}
{"id":"1a02ec7e-6eec-4056-af6e-97d4c309c49f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PUP792O0IW","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:f2fdc6c3-3b9d-4746-bce9-6ccceb7388f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11184","original_object":"UniProtKB:P09874"}
{"id":"5b7d063d-5a25-49af-93b9-cdb33c98a413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:89c2fe8e-a8f9-47a4-909e-a74b15a5bae0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q17ST2"}
{"id":"bafd3140-bfa7-4c89-a9be-1b98aeef6d54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2047","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:bc983bf8-0efa-4603-af67-dfd61a5b7fb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2047","original_object":"UniProtKB:P35346"}
{"id":"5ed5a4e5-99e4-48a8-b717-c3b041b9c96d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:8a582149-1d69-41a7-aabd-4824ea7c97fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:Q16445"}
{"id":"5f322367-a003-4a3c-8f33-556998af1bae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6804","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:72b97e23-b7a3-42f0-8b60-f1a333beb065","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7438","original_object":"UniProtKB:P08483"}
{"id":"0f1fa20f-976e-478a-aeb1-9113ea5b3bc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13402","predicate":"biolink:affects","object":"NCBIGene:2161","sources":[{"id":"urn:uuid:fcd7a01d-2806-48ac-84cc-c0af5ea39797","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13402","original_object":"UniProtKB:P00748"}
{"id":"28d2dfb8-50de-4809-b661-98eff8246ca6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:26580","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:5c8d8806-14ef-42ab-ae63-2dcb8ecb627e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4570","original_object":"UniProtKB:Q9NPD5"}
{"id":"d0e82235-0795-4721-802b-8fc341952b9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92163","predicate":"biolink:affects","object":"NCBIGene:79246","sources":[{"id":"urn:uuid:66a12c29-3ba6-4123-97c9-d5779436c3a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4316","original_object":"UniProtKB:P35563"}
{"id":"7b41352e-a55e-4987-b295-b4cbaac8faa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B4OQY51WZS","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:cb177d28-6a58-471a-a8c4-4646bfc7a55b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7844","original_object":"UniProtKB:P14780"}
{"id":"c2b6ea07-4f4b-42a0-9aaf-5eb95b910041","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2069","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:a11b86b8-67f2-4665-bd79-c6f0f6f2259a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2069","original_object":"UniProtKB:P31391"}
{"id":"f65577d1-c998-4deb-bc4c-0d0ec39b2d81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11607970","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:59655d9a-a845-4da3-b15c-f779bc3b13a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5785","original_object":"UniProtKB:Q8TDS4"}
{"id":"fe3f99e6-fbf4-4df3-be9b-8101a9e7e227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AZ9L8ZYZ3A","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:bfa08041-f320-41fc-b006-d18623f4abfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:934","original_object":"UniProtKB:P21918"}
{"id":"0587c9eb-44f2-49eb-8d3e-3825c6fcb723","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221648","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:0028a0be-ab17-496a-a499-5ba5084b01f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9465","original_object":"UniProtKB:O43614"}
{"id":"efd39f93-f22e-4d33-8186-3ef9edd34884","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11476171","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:fdcfdf25-9389-410d-9a13-3d033232f633","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8067","original_object":"UniProtKB:P08069"}
{"id":"0b343361-a7ff-4366-a5ed-a710e9b52ecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1100","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:af75a3c2-a788-4c86-a6fc-ce2f95326412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1100","original_object":"UniProtKB:Q92847"}
{"id":"8c78dd8e-d652-4acc-b07f-1a310dd85fa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:032ad579-b713-4daa-a6de-c12f09cd16e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:O08858"}
{"id":"b9c2e43e-39fa-450b-952e-08493cb426d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X741EI11EL","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:86dbd725-bcb2-478f-ab25-9b1b40f2fa0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1648","original_object":"UniProtKB:P41145"}
{"id":"168aac40-696b-474f-bc60-7d431b2ea125","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72708377","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:8cd581d0-67f3-4530-8d4d-6f490cd77a51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11646","original_object":"UniProtKB:P0C6U8"}
{"id":"66bab314-621c-4fd2-a1b7-b89f74bd84bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67259771","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:9199ee6b-7032-4be0-b370-e269c0a9c879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9108","original_object":"UniProtKB:P07333"}
{"id":"1558bff8-5e1b-45ab-be9e-9e9f8ab3f576","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2024","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:381c9f0a-7d0b-41ed-8430-23e1ac006ac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2024","original_object":"UniProtKB:P32745"}
{"id":"8b12afd9-44ac-4768-8e5e-14d0816d4ea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:25689","sources":[{"id":"urn:uuid:68a963a1-db62-4f39-bfc8-9910ce00b56a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P35364"}
{"id":"834bcfbb-1bcb-4273-8f2a-9d5537edca78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2188","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:689ee003-48a9-485a-bb0b-e143112b9ccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2188","original_object":"UniProtKB:P30560"}
{"id":"9a31f834-092c-4c40-b1d3-c9c4a9fbaff8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R6AXV96CRH","predicate":"biolink:affects","object":"NCBIGene:5595","sources":[{"id":"urn:uuid:31500c82-7688-4fbc-8c10-7f9191c4768b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9229","original_object":"UniProtKB:P27361"}
{"id":"b25e9235-9ff9-4774-97cb-530f2b23b1e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24857323","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:16ba938d-fa19-4aab-807b-408653b28c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8066","original_object":"UniProtKB:Q06187"}
{"id":"0ad968d1-edf0-4caf-a78f-956f60df8d15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137448670","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:ab9e18bc-12ff-482f-80fc-074f7b0fc68c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10743","original_object":"UniProtKB:O60885"}
{"id":"ed0d4e90-bd1f-417f-a4b8-4bbde874b98f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91453","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:e6dd0a33-251f-45c3-a034-4d05304c7c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5996","original_object":"UniProtKB:P53779"}
{"id":"4bb4cc9a-111c-4629-9f1a-e27a9c042976","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JC77BCH2AP","predicate":"biolink:affects","object":"NCBIGene:302813","sources":[{"id":"urn:uuid:d9cb9eb9-153d-4b49-aab4-89ae9e69e851","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12151","original_object":"UniProtKB:Q7TQN8"}
{"id":"fb7a98d2-1cf8-428c-9aae-b9e47851f556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:cacc16a0-059e-449f-bba6-19e9b5b016bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q8NEC5"}
{"id":"9abb0ff7-0f7c-4be1-9d6e-88caa48e96eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231352","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:47b79b2e-a4d7-436f-a3d0-7449d81cc1e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7502","original_object":"UniProtKB:Q9UBN7"}
{"id":"19a80b06-7c60-480a-9af6-b4623edb22e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17253208","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:3e0e5dc2-0ff0-4cff-9030-9153c56647f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9494","original_object":"UniProtKB:Q99500"}
{"id":"41a99dbf-6375-4be6-a8dc-fe3ec94ae2f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135443367","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:b9335311-dd68-4f93-b998-878a74412b53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:382","original_object":"UniProtKB:P30542"}
{"id":"01788e2c-acaf-48be-8596-fd52696b7f01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4630","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:c043e4a6-0c90-4bac-91d1-963f57fd0650","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13861","original_object":"UniProtKB:Q16678"}
{"id":"59921a8b-ed6a-4574-82b1-e735b5cfd11c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3603","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:e9d07e96-b873-4867-a2b0-5bdaf58638fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:308","original_object":"UniProtKB:P20309"}
{"id":"c36ddb32-0498-4d59-adfd-fd6de0723cfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911338","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:4ba2001b-374d-4266-9250-d9c214d2ef89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10437","original_object":"UniProtKB:P23443"}
{"id":"1b29ca0e-5e9f-47cd-a406-8a5091e7a791","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90679","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:7b4e6862-6c94-4abb-80eb-1343432034d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5704","original_object":"UniProtKB:P42345"}
{"id":"d05a9a0b-2570-48f5-86f8-45a4c300920f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4164","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:92c4b460-9ab1-409a-a1c2-b3a86767e754","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4164","original_object":"UniProtKB:P23416"}
{"id":"ea19c310-a83d-4d1c-b581-4edceee48dde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:37750349","predicate":"biolink:affects","object":"NCBIGene:3654","sources":[{"id":"urn:uuid:7ad5c305-a36b-4312-90ba-c6eaa2b033a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9655","original_object":"UniProtKB:P51617"}
{"id":"8ebaa806-10cd-4eb9-9c52-d64fc48c9f95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366968","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:95b683fc-c34f-4777-afd2-9ed25c48219e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11775","original_object":"UniProtKB:P56817"}
{"id":"b0db6d5a-413c-4436-8638-c3089a83d943","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137029447","predicate":"biolink:affects","object":"NCBIGene:55193","sources":[{"id":"urn:uuid:38b14800-ea18-41f0-91f4-96563b764df6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12206","original_object":"UniProtKB:Q86U86"}
{"id":"da1f7c1e-614d-43cf-8144-da9413862e1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:a68244e9-d491-4e31-bc7e-fc095a73cf3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:P35968"}
{"id":"1ea43298-18e3-4b4a-a22f-be6dbe590f81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:359","sources":[{"id":"urn:uuid:6f2ac7ed-3c57-4de9-bd22-53d3ec7d0363","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:P41181"}
{"id":"2473c4e8-0f89-4129-81f0-f1fb9a553909","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827353","predicate":"biolink:affects","object":"NCBIGene:29994","sources":[{"id":"urn:uuid:7fcf1f45-dd9f-4892-bec5-58b24a038c09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8306","original_object":"UniProtKB:Q9UIF8"}
{"id":"1f207f2f-fca3-49ec-b875-c86a7fe12b9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:56R994WX4L","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:7957e557-f582-481e-9b09-83ffa6d29e7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7839","original_object":"UniProtKB:P29597"}
{"id":"9b9eb78a-bab3-4c1d-ad00-7767784e411b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131351","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:6746120d-e1b9-4acb-a4f3-e30fb99457ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:384","original_object":"UniProtKB:P25099"}
{"id":"dc52356a-880f-43dc-a913-850e6d35189b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:7b1c099b-ffbb-4f79-a580-0820f2d07cb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q8WUI4"}
{"id":"0761ac39-e6ce-4e21-885e-29790b62eaee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91471","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:3ff6349e-3cd5-45be-9cd0-68369eaad1d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5672","original_object":"UniProtKB:Q9NRM7"}
{"id":"dbeab0e9-3b85-45ac-9bd6-03064985d726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86304165","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:418410ac-7c51-4180-b1ba-0764da5a87de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13494","original_object":"UniProtKB:P11362"}
{"id":"16f3c456-ce92-4b4d-a1c0-f8f7283f16bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22524604","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:6dfd97ed-2965-4183-9ef8-cab5506fb7f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3332","original_object":"UniProtKB:P21731"}
{"id":"286b0a56-bc8a-4391-b1b7-4c1d08a0a07d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82698","predicate":"biolink:affects","object":"NCBIGene:230777","sources":[{"id":"urn:uuid:389aba86-bb0d-4762-a7a2-14451b7784c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2890","original_object":"UniProtKB:P58307"}
{"id":"afa13b1f-71d4-46dd-becf-de3ac9eda90d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W9F9H8GXWR","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:3373342d-2ef6-4cc4-91b2-52ff88f82d28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7416","original_object":"UniProtKB:P06401"}
{"id":"2410a4c5-907d-4a06-a293-22f6f022d10b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5070","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:669cc5a7-d372-416d-976b-347de25a43e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:408","original_object":"UniProtKB:P0DMS8"}
{"id":"4aa4613d-f5f4-446f-8853-ed5e229746fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321147","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:8e0ece9a-1cfe-4da2-bb17-b067291f6e3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10107","original_object":"UniProtKB:O15552"}
{"id":"3920bed3-24e1-4797-a136-704f7df1dd24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:e26eb535-639e-4788-892e-d6d722e3d221","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P28334"}
{"id":"a2e4279d-61f2-42fd-b84d-f16d9e62b454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9622","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:7ccdf2cd-4c3a-47c7-b9f5-006925fb226b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:360","original_object":"UniProtKB:P08912"}
{"id":"05c46bd4-56e9-4d6a-903d-0597d273def1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6134","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:bf3dc428-fa62-407f-a0c8-9f15fef30d3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6134","original_object":"UniProtKB:O43603"}
{"id":"3e01cffb-c715-441e-9ccb-2a0d2b902dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6706","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:f32216c9-834f-46bf-9609-0674b35a3307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3990","original_object":"UniProtKB:P43681"}
{"id":"f41070ba-e3f6-4299-8e91-3f77b9091512","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611886","predicate":"biolink:affects","object":"NCBIGene:9020","sources":[{"id":"urn:uuid:013d1404-d8b9-4b29-9a0d-6dbb9bdf420e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9965","original_object":"UniProtKB:Q99558"}
{"id":"c7f3f4e6-7ed0-4bf2-877f-40d43d5cf103","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10567","predicate":"biolink:affects","object":"NCBIGene:2838","sources":[{"id":"urn:uuid:7fb5b1b8-c633-400e-8638-a0bd556ffda1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10567","original_object":"UniProtKB:P49685"}
{"id":"b255ca48-712e-4d44-8a25-9700141b3137","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8G388563M7","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:30b89312-05da-4420-97f9-a6e3e3087a4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9490","original_object":"UniProtKB:P17752"}
{"id":"d071a7de-4be5-4c64-9066-34f28d87c51d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137064","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:62f53d3b-d873-419c-8b6a-d28ea446c29d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7797","original_object":"UniProtKB:P36897"}
{"id":"7b536ac7-830e-4480-8287-4d585c3dd3e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10200069","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:d5d912d1-6a21-46d6-a48a-061275d949cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5722","original_object":"UniProtKB:Q8TDV5"}
{"id":"71293874-3573-44a1-b7cb-a72dafc15b94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:c907dd63-aa50-44b5-a950-c624b7938efe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:Q9Y243"}
{"id":"1e2248eb-0f47-4c3b-97ca-897074016ec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11496610","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:2fcaed56-db93-4baa-b246-f86038868302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5582","original_object":"UniProtKB:P30968"}
{"id":"246eb184-eb11-4048-b666-62cbda0e4570","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1495","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:670c3de9-03da-44dc-ad5e-373251a6af08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1495","original_object":"UniProtKB:P48145"}
{"id":"71bd4803-c7f5-4c3a-803c-b1cbae9cef72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101930759","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:08cea76a-699f-4568-808d-5288c3852a7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1461","original_object":"UniProtKB:O43193"}
{"id":"08b11bd3-3e7e-4310-8107-2eafa8ae98db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:91a5e2a4-f263-48e3-8a86-22af5b660302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:P56524"}
{"id":"d86587da-b6fd-484f-a290-36670b8c3a17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603800","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:19375bb8-a4dc-44e1-b406-658dfb80b4e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:956","original_object":"UniProtKB:P14416"}
{"id":"b5709ac2-a3b3-45b8-8c82-8a5d90754e2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104929","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:e033d702-71c8-48a4-a089-582ef4b08207","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:879","original_object":"UniProtKB:P30551"}
{"id":"ed6a3e6a-6237-4a14-8eaa-baf96d329aa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZE94SP78UG","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:467c6ff7-7e29-4192-be78-5faf1df41aa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13496","original_object":"UniProtKB:Q96GD4"}
{"id":"b08834d6-8f79-4a17-be85-29655c89e992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63450","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:46aa2f2e-02c6-45bf-b905-94db6e7e5b35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5656","original_object":"UniProtKB:P10721"}
{"id":"389c1cae-13db-4bd2-9efe-43f3f55c84d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229225","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:0fe8b00e-a088-41e9-9ab6-b3fbf6f37c5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12335","original_object":"UniProtKB:P31639"}
{"id":"b2577ef6-b785-4a6e-a5fb-b17fc21cda24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11624601","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:092d2b13-2409-4366-ab54-ac1d8a9ac1da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5998","original_object":"UniProtKB:P45984"}
{"id":"8bf7561a-78bb-43ff-8972-e628094907d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81529","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:2fc246c6-cf52-4a1a-9f4b-c201cf2c2b96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1642","original_object":"UniProtKB:P33534"}
{"id":"c2c27c6e-294d-4a7a-8074-0d71df8d2af2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122192273","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:87556426-266f-439a-9899-ed1e3ea0b77d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10035","original_object":"UniProtKB:P55055"}
{"id":"0506afff-73cd-471a-8fa6-756ba5e9761b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:3f7fc7c4-7bc8-4f04-ad90-9e66de6b1b91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P30542"}
{"id":"da62f458-546b-4308-a059-2366c882034b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:161880","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:a33567bd-99c5-46e7-ae05-2e28185e02ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12453","original_object":"UniProtKB:Q9NYV7"}
{"id":"c4928fe7-ae0b-4d5c-b7a1-97895f41dfe4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134378796","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:a9706824-7e84-4400-9be8-dd50570ea0fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12560","original_object":"UniProtKB:Q9H1D0"}
{"id":"ac152695-ab24-4aad-ae24-834873ccaad0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8D47339CYL","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:95d2d5f6-6ec0-4083-b21f-fbf947862445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1340","original_object":"UniProtKB:P32245"}
{"id":"6dcc3ba1-8eb2-4e35-8246-8505d10e66a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53490","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:3525f24c-ae3d-45d6-b700-3575a58a39aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1022","original_object":"UniProtKB:P21462"}
{"id":"58b21501-c26c-4728-b5b7-ee6402e976f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CKU8PTZ7M8","predicate":"biolink:affects","object":"NCBIGene:6576","sources":[{"id":"urn:uuid:08f7cf43-6ca2-4e03-9238-6a28bc8b3440","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4701","original_object":"UniProtKB:P53007"}
{"id":"aeb4ad79-c54e-4978-938a-8f00105705d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311320","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:0df9ec07-f845-4b73-b0e9-91f11cec1386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1572","original_object":"UniProtKB:P30989"}
{"id":"faa6557c-417b-40a1-bb17-7be9483111c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:c17f0b29-5132-4020-a595-fe9c8ec38cfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P39900"}
{"id":"82a7c690-1431-46b0-b642-3d18201eb86d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:f8eb14e4-6cbd-4c4c-8953-76fbb34d2794","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:P34995"}
{"id":"ef5568c2-a32b-4214-99dc-a97b75882064","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188278","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:96cc159e-f07e-43b4-80cd-456941ac9212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7545","original_object":"UniProtKB:P23975"}
{"id":"cbe6c4cc-d82e-47bf-af05-ea2ba778c7f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17737","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:721f2d06-8ed6-441e-9b48-8373aad6eb74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2748","original_object":"UniProtKB:Q13133"}
{"id":"c490e482-306d-4e83-8a71-31567a1e4def","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QA8MW1Q80P","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:8e9c70e1-f0b8-4a06-abaa-55de5b762a59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12190","original_object":"UniProtKB:Q96RJ0"}
{"id":"f3ddef43-670d-47d3-9332-35082b0a2123","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94810","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:a82d5256-a89f-4402-85a7-2771909640d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3634","original_object":"UniProtKB:Q9NS75"}
{"id":"ffe98542-1899-48a5-93cb-d879c10769c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77572","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:1dc1978a-6981-40dd-9d11-21daf78f0051","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6326","original_object":"UniProtKB:Q9Y5S1"}
{"id":"27989719-d2d3-4b40-92ff-1f10ce2e55c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:1667d3ab-70d5-4817-9f22-456e227cd99e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P08908"}
{"id":"e6853a43-081e-47ab-9f51-c9a7aee37103","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:252696","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:62243bce-6bf6-4317-935f-04e7d3a42ff7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:429","original_object":"UniProtKB:P29274"}
{"id":"22b60e2f-1d2e-424a-9e60-9a17abd938d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3914","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:8ba76b87-cae5-4d92-9e55-3a170b2aef3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3914","original_object":"UniProtKB:P55085"}
{"id":"0b56668f-056b-4a50-95fd-aca5ee62bbf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:83795","sources":[{"id":"urn:uuid:79752924-156c-4f2c-8984-d2d0ddc05215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q96T55"}
{"id":"b2daddb5-0278-48c4-8386-63301c11740b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817491","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:cf7e3e7e-5dae-4cd1-abca-89afe69652c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6175","original_object":"UniProtKB:P30550"}
{"id":"e769a009-c4de-4f5a-819a-0597d858afa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121260977","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:addbad4a-8e94-4bcf-99cc-68ae99d1545b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13811","original_object":"UniProtKB:Q9UM73"}
{"id":"bbd38d83-0109-4478-b43e-642302ae499a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59224","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:4fc1e53a-2458-4a0c-a9ac-b5945b6a9ee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1190","original_object":"UniProtKB:P30968"}
{"id":"1060de3c-5a91-44b9-a129-7788d6917e2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488883","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:324db041-03b0-481d-9194-af0cbe4e211e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1762","original_object":"UniProtKB:Q96G91"}
{"id":"53cf4f58-5d1e-4cbe-b716-33df8d975ea6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:af92a59e-3228-488a-b89e-bfecf95148c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P21731"}
{"id":"3c50b4af-c6ee-4049-90c7-c3a11e5c3c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92019","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:988c25df-d0ca-4551-a5e6-8abdcb1fc3c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5170","original_object":"UniProtKB:P45452"}
{"id":"6481f4a7-230b-4f30-8d2a-18637ecd80db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311469","predicate":"biolink:affects","object":"NCBIGene:24326","sources":[{"id":"urn:uuid:4c79dedc-2694-47c6-924f-a5c037e9940d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3913","original_object":"UniProtKB:P26684"}
{"id":"56ab6a97-b246-40be-ab50-71315e76b7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91366","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:01331748-b996-4c67-982b-31676cbd27e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5696","original_object":"UniProtKB:Q96GD4"}
{"id":"65d80f9c-8987-4569-bcc5-3715e39a5e73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XX2MN88N5D","predicate":"biolink:affects","object":"NCBIGene:3683","sources":[{"id":"urn:uuid:8bf4c832-5c39-4031-979d-984e173fedae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6593","original_object":"UniProtKB:P20701"}
{"id":"103766d1-ca57-4e32-82bf-6f3da07be923","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143992","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:131c5397-92f2-4c42-b06a-6d58191cb4a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1410","original_object":"UniProtKB:O00222"}
{"id":"25eba43c-c372-421d-9499-ff1581b900f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63949","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:ae789adf-084f-4fcd-8878-3d4805468c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2825","original_object":"UniProtKB:P03372"}
{"id":"6f568a23-6940-4691-aa3e-91a1f907cd33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:67b923f1-0471-4e41-924b-5a7288588cd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:P35349"}
{"id":"8bbca1ca-a743-424a-ba93-bc335635f5fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64019","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:00868351-7b52-42f6-a32b-c718edcc0296","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7246","original_object":"UniProtKB:P07550"}
{"id":"50f8937e-dc40-46b9-95e3-8afb0b05a936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321156","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:82307e5c-9e09-4b89-8fa5-90f8ee9a2b5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10148","original_object":"UniProtKB:P23458"}
{"id":"2d308e5d-48d0-462e-a412-5253a976cf37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16167454","predicate":"biolink:affects","object":"NCBIGene:83567","sources":[{"id":"urn:uuid:766a7465-b11b-4dc8-a2ae-5c29bdd2272c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1298","original_object":"UniProtKB:P97639"}
{"id":"8eeac3b6-1a47-4af5-95b9-2835e5902538","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:572","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:c8295023-70d3-46a4-a974-0fe778966a1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:572","original_object":"UniProtKB:P21730"}
{"id":"ac120866-3d7e-4c26-a889-0783084ad78f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:78I4VEX88N","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:1d42c160-77ed-4cc9-ada9-1e8aca768fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7880","original_object":"UniProtKB:P15056"}
{"id":"efdd0124-e417-437b-93f3-6b0e0bb2b6e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145984892","predicate":"biolink:affects","object":"NCBIGene:4759","sources":[{"id":"urn:uuid:b2f275ef-4ede-4e6b-a48d-5c39ad40bc52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13013","original_object":"UniProtKB:Q9Y3R4"}
{"id":"9502826c-776a-4c2d-a0d3-a08b8d9bf8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135522368","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:9f3a3dd9-9544-4552-b8a7-2aa21002771d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:383","original_object":"UniProtKB:P29275"}
{"id":"4d39c0b5-9b50-42f5-861e-9d345252add9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494540","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:528fbd79-7cbd-48e3-b133-34884aad418e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13635","original_object":"UniProtKB:P0DTD8"}
{"id":"bc47ffce-4931-4d74-9011-07ec6d00899f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:117155","sources":[{"id":"urn:uuid:c4710bd7-1aba-438a-8868-34dbf56b7d53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q96P56"}
{"id":"5699d3d3-855c-4375-b519-3f56509f4a13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3712","predicate":"biolink:affects","object":"NCBIGene:229214","sources":[{"id":"urn:uuid:35720749-f8a1-4ca4-8a2e-8ccc867379ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3712","original_object":"UniProtKB:P83861"}
{"id":"744df89c-ffd8-4183-b530-54dbb514649f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9A5LBZ98YY","predicate":"biolink:affects","object":"NCBIGene:243764","sources":[{"id":"urn:uuid:9a41e5ad-3fc2-410c-b188-3bf91ba83e12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3266","original_object":"UniProtKB:Q9ERZ4"}
{"id":"63ca23a8-da97-4d90-b896-54621cacad52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188061","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:6d745cc5-4507-410e-8c35-8b7c3087d707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4339","original_object":"UniProtKB:O00519"}
{"id":"3aaf586b-13da-4f4b-b43e-90bda3701ccf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7454","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:df61ebc8-4134-4ffe-847e-7aa5438c2c77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1663","original_object":"UniProtKB:P41143"}
{"id":"deafd450-db2f-4cc1-a982-0aceb8be7dc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42549","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:6ed22647-32a7-4640-b4ec-b13b97cd681c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4070","original_object":"UniProtKB:P42263"}
{"id":"75335c12-ca8b-4612-94f3-e16d4a7552ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52140","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:051d5b4e-eb69-4179-8860-17bfcf855782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10285","original_object":"UniProtKB:Q9UL62"}
{"id":"1786cfe6-de93-4a84-87c4-f12cae989f17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13904","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:fbfa4609-5873-4b38-8d0f-6270c40c1433","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13904","original_object":"UniProtKB:P0DTC1"}
{"id":"6a6ae060-98a4-4e84-8d7d-fb28b2deeb82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11776","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:28c6dea7-fc6b-408c-9780-57ce131cb3dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11776","original_object":"UniProtKB:P21589"}
{"id":"72835385-4b48-4aeb-b355-128b2de0dc5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73858","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:3e2907aa-4b00-4283-b668-aed290bb1348","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5651","original_object":"UniProtKB:Q8TDV5"}
{"id":"3d325410-eb5d-47cb-8e6b-5bdd7a9d5643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:787","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:b4e69a50-963f-4753-af36-9de22cf6db11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:787","original_object":"UniProtKB:P51677"}
{"id":"c7bebd89-852a-4d9d-bda2-9cf6cf09b161","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2563","predicate":"biolink:affects","object":"NCBIGene:3742","sources":[{"id":"urn:uuid:2523bb78-3c31-4872-897a-5535c0549238","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2563","original_object":"UniProtKB:P17658"}
{"id":"3c38cdc1-0480-47de-a63e-d2eb725e3688","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:abaa1c57-54ed-4862-9263-869f3792a54e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:P42338"}
{"id":"ef72ee13-8bc4-4674-90f6-36d61678ed6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91426","predicate":"biolink:affects","object":"NCBIGene:5871","sources":[{"id":"urn:uuid:103e8e5b-45c1-42a9-8da5-28542c92b723","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9693","original_object":"UniProtKB:Q12851"}
{"id":"fd7186d5-7416-4822-a203-683729473d84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92998","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:320ac759-54fb-4153-b7a7-a2206f8e9f38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5443","original_object":"UniProtKB:P18089"}
{"id":"758eaaf2-b06f-4a35-9b88-4de9b53a813f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7D07U14TK3","predicate":"biolink:affects","object":"NCBIGene:5499","sources":[{"id":"urn:uuid:d1d0007c-cdf6-4a8b-8fd6-40ebc7c71b18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13083","original_object":"UniProtKB:P62136"}
{"id":"88613abc-bb79-44d9-ab1f-0c17c61371d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14660352","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:4dd6b3c3-8c18-4e47-b3f9-b86b8df7edca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1219","original_object":"UniProtKB:P35367"}
{"id":"9fa1386d-c4c8-4364-a588-132794fa317c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:759","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:eb06bdbd-415f-43d7-b728-c40c7c4947e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:759","original_object":"UniProtKB:P51681"}
{"id":"46d3b5b8-c540-4274-b302-7b790f438e57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78549","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:a5f8812b-8c3d-4139-8996-aa45e3af2dd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:92","original_object":"UniProtKB:P28223"}
{"id":"b9f723e7-2ac7-42e7-bb59-0690c8f9d172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4W39NS61KI","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:c0f340c4-cddb-4a96-8ef2-8144bb6c3c5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7936","original_object":"UniProtKB:P42345"}
{"id":"e4290170-935b-4e63-9d74-f1dd1fd12d5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:3a4152c2-3cba-49d9-898e-c9ef85d9fc5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P30874"}
{"id":"7429bf51-95fb-4a87-8559-52c303c3955a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2214","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:093e75bf-9b5f-4ede-a704-5233e66bfa43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2214","original_object":"UniProtKB:P47901"}
{"id":"b86acd05-d56b-44d7-b27e-2664508fa075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:0f922f8a-50ef-4590-8d87-59ceca25faa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P35367"}
{"id":"92b105c6-0d96-4537-94ca-2b7d0dad1886","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:033e9426-aeab-4d82-b284-370af8e2172e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P18825"}
{"id":"d6670cac-8dfd-445b-befc-8badb2e96f8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:e077344e-0c6d-4bbf-a502-402cd9edd4e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:O88626"}
{"id":"6dd36c78-7c1e-4931-92fe-93be723c3ba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:935cfad5-bbd4-4322-bfd1-be140315a597","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P09619"}
{"id":"827f11e4-47ea-48bb-b926-b44631a2b106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VKU5X213Q7","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:64233283-e85e-4815-91e3-0fd774c32a45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7879","original_object":"UniProtKB:P00533"}
{"id":"c842942c-3978-43bd-af04-60140e67bca6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:19cbd2c1-0c77-46f1-8692-ace0adbfaad9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P30938"}
{"id":"81ba5ec6-b6d5-4412-baec-4191965a11fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132084","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:dc2b0da8-2f9e-4769-8a7e-c4afdaea1315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6043","original_object":"UniProtKB:P35968"}
{"id":"e6123493-dfa7-48cb-8ecd-18148273388f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:820","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:58656f41-8392-4213-afca-373c891fd3a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:820","original_object":"UniProtKB:P25024"}
{"id":"a94d7ae6-07af-4f33-aa46-1bf43abe2880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17780","predicate":"biolink:affects","object":"NCBIGene:153201","sources":[{"id":"urn:uuid:d142bbb0-5528-41f2-a9b5-54c7f64126b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4671","original_object":"UniProtKB:Q495M3"}
{"id":"d76c9536-b28d-48af-ba9c-1f3bedc77f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3549","predicate":"biolink:affects","object":"NCBIGene:8323","sources":[{"id":"urn:uuid:0451cc92-7408-4f28-ace0-97ef04ef913d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3549","original_object":"UniProtKB:O60353"}
{"id":"f2a93562-574f-4128-9cdb-21877d38e421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66910","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:f2070781-259d-434b-8dba-08d8f94f6abc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5659","original_object":"UniProtKB:O00444"}
{"id":"84a130d5-696a-4a10-8768-46c3443bd9bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1988","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:59d7933f-957e-4bb6-9d53-a697e944a468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1988","original_object":"UniProtKB:Q8WXD0"}
{"id":"19ed2817-11b2-4138-adc9-6ccde61cf855","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23725180","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:03c875bd-e56c-440a-a542-6a54b91cc50b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11597","original_object":"UniProtKB:P41597"}
{"id":"c18f50c7-0b2f-420d-a329-eaddeef79701","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4615193","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:c1a78970-b440-4166-a8b4-655e061fe2ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4141","original_object":"UniProtKB:P42263"}
{"id":"2c98b37f-3904-473d-aa7a-4963c6fd9c4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:45dc7254-c132-475f-907b-5cf61da3321f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P28223"}
{"id":"8bdabe6b-c6ef-4ec1-b87a-dcfda4da7882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11847343","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:3002324f-08eb-4def-8ae0-61967758909e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8768","original_object":"UniProtKB:Q96GD4"}
{"id":"4903a677-17ce-4b04-b52b-387921047928","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114187","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:ee1bf7ce-35ea-4af8-b3b1-9bbbaa20e70e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9002","original_object":"UniProtKB:P41143"}
{"id":"518ca04b-05ae-422f-a12f-dcbbf3fdaec7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:ad91c8ea-ddc9-4a15-b7de-d5cb6fb65def","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q8R455"}
{"id":"106a0ead-760c-4351-aa12-1d3feb924aee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072549","predicate":"biolink:affects","object":"NCBIGene:29117","sources":[{"id":"urn:uuid:c828f977-ab04-4637-a29c-23dbecfe6c97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8950","original_object":"UniProtKB:Q9NPI1"}
{"id":"d1b2627f-47a5-4fb2-944c-a882705b48a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10065929","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ea2885b5-177f-42cb-b204-4c8169f3ff69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:469","original_object":"UniProtKB:P0DMS8"}
{"id":"ff95c50b-aa43-4dc9-ae0d-b3c65b1ce682","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46232606","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:e70f1054-c8dc-49a3-af8f-9706ca2fc212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8606","original_object":"UniProtKB:O00519"}
{"id":"b71ba6d5-49e2-4dc0-b2c5-02d3c6076b44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2945","predicate":"biolink:affects","object":"NCBIGene:2825","sources":[{"id":"urn:uuid:0ecab07e-a4e1-4cf3-8831-2a3e99401ec6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2945","original_object":"UniProtKB:P46091"}
{"id":"e0dfffbe-02ea-42fe-9760-a57c5292c773","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T41737F88A","predicate":"biolink:affects","object":"NCBIGene:2152","sources":[{"id":"urn:uuid:a14f6fd6-3393-4ff4-bdfa-7df9f476a920","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11719","original_object":"UniProtKB:P13726"}
{"id":"8334734a-5164-4a56-8488-60f4ca3f234d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030518","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:388d3380-b914-46af-86b5-a695148b257a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10420","original_object":"UniProtKB:P16234"}
{"id":"258f8845-b468-4939-9d11-082c3d37aca0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:aff10553-6ae8-4e25-ae7b-b85a5a1824e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:P78527"}
{"id":"57ca70d2-6663-40e7-a9de-f47e5773fd0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9805004","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:fa805fd0-d8cd-421a-8b44-016f45d5a36b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8643","original_object":"UniProtKB:P04150"}
{"id":"92a871a4-478d-4604-b1ca-7fc493c57648","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3700","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:40f3c556-5473-4177-b046-18de42bb7bb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3700","original_object":"UniProtKB:Q9HBX8"}
{"id":"a09b1b1d-60b1-4e43-9b90-759d670fd745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8211Y53EF","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:a29f21cb-109e-424f-96f3-ada5444d2a65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9232","original_object":"UniProtKB:P20272"}
{"id":"f384c69c-9aa3-4fa2-a5d7-0f107ecb2c15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3724","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:a3b3d4c9-4327-42e4-99cc-288aecfd88e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3724","original_object":"UniProtKB:P21730"}
{"id":"b5601e2d-eadf-482c-8b6e-8c67a19895bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:596810","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:23cc0882-26b8-43a7-90ca-91ed8e085d55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2494","original_object":"UniProtKB:Q8K424"}
{"id":"00574f39-35fe-46fb-b303-4e1a113ece16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130306983","predicate":"biolink:affects","object":"NCBIGene:3417","sources":[{"id":"urn:uuid:eb127a28-afde-4bb2-8ac8-0ff4836ef5d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11884","original_object":"UniProtKB:O75874"}
{"id":"3f119340-d7c9-48c0-b192-ab7a0e6489cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38927","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:844826a6-ea4f-4078-a246-696902c30694","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7644","original_object":"UniProtKB:P00533"}
{"id":"870a49e3-6f7e-4005-a9e9-e8b1578a332f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5262","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:1a31073e-084c-4de9-a7b7-43654761cc29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:410","original_object":"UniProtKB:P29274"}
{"id":"c771b26c-9ea1-4686-97dd-001eb880caf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90841","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:583b976f-0f1a-4ef0-b8ad-ab6859acfcaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1776","original_object":"UniProtKB:Q6NS65"}
{"id":"3d6d2524-db64-4852-9390-7f8211686fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73274","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:2a4e2c56-6f8a-4907-aa48-b5f51e1df7dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4582","original_object":"UniProtKB:P31639"}
{"id":"afbd6cef-1b73-4f4a-a846-142325343f83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6076","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:1134261d-6712-44a4-ad1f-0a866af09f59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6076","original_object":"UniProtKB:P47211"}
{"id":"0361943d-762b-43a7-8c37-c7e37ba61c7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23670447","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:b938167c-ade1-4434-b954-e474363e5bef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:999","original_object":"UniProtKB:P25101"}
{"id":"e27ae72f-1df8-4388-aa1f-8a93a1c5508a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71200","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:7e515974-6260-499b-8ab2-62da412ba687","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5677","original_object":"UniProtKB:P23458"}
{"id":"18d9e987-ea91-4a13-a8af-b050409fe3ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10278166","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:8fb508bf-b2fd-4ec3-a3cf-6bf09b511ee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3531","original_object":"UniProtKB:Q9UKP6"}
{"id":"5db67206-637a-4c77-8f0b-11cbc328136f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156855755","predicate":"biolink:affects","object":"NCBIGene:8463","sources":[{"id":"urn:uuid:b3430066-1c9e-4af2-9696-0c4723ef3efe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13367","original_object":"UniProtKB:Q15562"}
{"id":"aa83486f-5c52-401b-8838-8f804e0a0b24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1M7NI1A92L","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:15f91cc7-7399-4987-bc42-873383001e49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4095","original_object":"UniProtKB:P14867"}
{"id":"0b4ca24c-1124-46bd-9436-94e2346a0e3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13364","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:ecce9014-1bfe-4c1a-8fad-9c9f6eec89a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13364","original_object":"UniProtKB:P00533"}
{"id":"a23a47ea-096c-4ade-be97-e29c7b224f8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0661V34NTV","predicate":"biolink:affects","object":"NCBIGene:27346","sources":[{"id":"urn:uuid:6b5119d0-dc69-4122-97d5-1075a92471fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13335","original_object":"UniProtKB:Q5BJF2"}
{"id":"6254c2a0-cfe5-4a4f-a5c4-92c7f5ab4657","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393289","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:bfe2bddc-10f3-46ad-b3b3-cb3fbfc412f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10385","original_object":"UniProtKB:P35968"}
{"id":"24ef232b-4e90-41b4-823c-54296bb64b4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101493753","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:893dc47e-bdc5-43c1-bab7-4eb81b060b59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1488","original_object":"UniProtKB:Q9Y5X5"}
{"id":"58406b5a-9861-4341-ab3a-f9ba8a3e4f33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46235922","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:1063a3ae-66e5-49a2-8297-202d5a5e4bd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9402","original_object":"UniProtKB:P53350"}
{"id":"c893b7b6-57ae-46ef-8f06-ca60905aaed2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5095105","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:49d20d98-4f4a-45a6-9035-eda5d9a4ea40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13883","original_object":"UniProtKB:P19099"}
{"id":"002519e3-31b8-4523-96ff-c559cf704acb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70707","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:8d63e81d-f28e-44e3-9d04-4e0b2ce02bae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7427","original_object":"UniProtKB:Q13639"}
{"id":"ef40b060-9b17-4123-bb7c-51d8e54189fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:799","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:c8cb704e-bcee-4404-8dae-423a917cae47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:799","original_object":"UniProtKB:P51681"}
{"id":"6bb6d7dd-0f30-40ef-a455-d7f2120bbacd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5297","sources":[{"id":"urn:uuid:4f7cf816-b350-4a7b-9189-b94df9e9e82c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:P42356"}
{"id":"50a57338-ff81-4e52-97f9-3319e770bd5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:89d90121-fbe4-47b8-8f40-dd5792fe06b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:O35433"}
{"id":"166d49cd-e01e-4b63-9b40-fb08fde7bdcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13547416","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:51fb574b-e97a-41aa-8ed7-7c2e424738bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:169","original_object":"UniProtKB:P41595"}
{"id":"13b212e8-e453-454c-88b1-de6697e70712","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135653","predicate":"biolink:affects","object":"NCBIGene:7201","sources":[{"id":"urn:uuid:10fbdee0-f227-47a5-a7d3-2fba9517b314","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2143","original_object":"UniProtKB:P34981"}
{"id":"901946ec-9e3d-4ae9-bf66-66a7451efead","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3755","predicate":"biolink:affects","object":"NCBIGene:6344","sources":[{"id":"urn:uuid:01626429-aa3c-4a9d-9a76-cc5c06d8a876","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3755","original_object":"UniProtKB:P47872"}
{"id":"5f3c9438-2e40-493b-a762-b5388b4731b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2003","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:2006f8e7-9391-4026-8a27-cbcc413c2cb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2003","original_object":"UniProtKB:P35346"}
{"id":"f85397d1-77bf-43d1-b595-725e2b921021","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166176990","predicate":"biolink:affects","object":"NCBIGene:641","sources":[{"id":"urn:uuid:232172f4-799b-4ded-836a-28e480469b91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13025","original_object":"UniProtKB:P54132"}
{"id":"f5219ab5-0cf3-4c4d-bb1b-6e77a5226ed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DAV805YGOX","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:f0382ab3-ca11-4f48-8d2d-9d3f4b1bf15c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3252","original_object":"UniProtKB:P08908"}
{"id":"43006a37-890b-45b6-8547-fb151b8d9d4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118977746","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:09778efb-a2bf-4896-b228-60a6b53ef013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10078","original_object":"UniProtKB:P51449"}
{"id":"9c6e1cdd-1cf7-4010-8ac5-861ded7b1b26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996526","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:b83e4250-b125-4508-921b-25b05eb4deab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10596","original_object":"UniProtKB:P07333"}
{"id":"2678a07a-9e18-48a5-959d-714e66034ad0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49765871","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:92cf8fab-90d7-4baf-96da-86cc09bb5963","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6317","original_object":"UniProtKB:Q14416"}
{"id":"d66b7f15-3a73-45c6-8357-513cf7b8eecc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230832","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:26b30321-3878-474b-bc1f-c25eff345830","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12576","original_object":"UniProtKB:P08913"}
{"id":"aa714b5b-1c1b-42ca-8ba0-16468c648c30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65324","predicate":"biolink:affects","object":"NCBIGene:3320","sources":[{"id":"urn:uuid:36dc0fa5-5e18-47e2-903f-7ce300d78c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9828","original_object":"UniProtKB:P07900"}
{"id":"2da2f768-706a-4ef7-b34d-5b0a66f9fd94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3X8387Q25N","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:3c26899e-51a6-4d59-bd58-4d2fccfa0d54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10459","original_object":"UniProtKB:P23458"}
{"id":"0d41001f-4472-48d3-9a2c-ba72c50d9310","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115219","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:4409dfff-f490-40ba-8270-fecb1879e002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3414","original_object":"UniProtKB:Q9NS75"}
{"id":"cb0e7fe7-ef23-49de-82c7-9e110172f759","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996513","predicate":"biolink:affects","object":"NCBIGene:8111","sources":[{"id":"urn:uuid:4a3293a3-da55-4ce9-8174-f081d02cd48f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10570","original_object":"UniProtKB:Q15743"}
{"id":"0fc2568c-a5b2-4a21-b63f-1a930e8131d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58141","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:6dc6fadf-c950-478f-acfa-b93d828195da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1732","original_object":"UniProtKB:Q9BPV8"}
{"id":"00f8da87-83d5-474a-b30a-63fa3218fc63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393293","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:011a78eb-f942-48a0-b82a-42c819973e00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10401","original_object":"UniProtKB:Q13546"}
{"id":"8a935881-b75a-4623-aeb4-1fbcecfd0a4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93641","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:ae1017b2-31e9-4469-8f70-d487b65134b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5924","original_object":"UniProtKB:P49840"}
{"id":"d99caaba-0784-44dd-a0a9-20480e68ddde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92339","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:b72c51f7-5828-4e8b-8e3f-5d43358453e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10348","original_object":"UniProtKB:P21554"}
{"id":"a60631f9-044a-473d-a113-be5e6f51cc68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139415233","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:ec6530bb-6245-4ab4-b301-cfec462768c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12865","original_object":"UniProtKB:P35968"}
{"id":"2d7516eb-2c0d-4e01-985c-4f2aeb204d0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140296","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:36df08f3-9653-47ff-ad74-fd2b13a230b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6352","original_object":"UniProtKB:P12821"}
{"id":"6442b453-6fd9-4a25-bf9a-84198e6a85db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QI52W1ZIIB","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:7e61a6f0-21e5-4f27-9c7d-1a1c9fc0e9cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12084","original_object":"UniProtKB:P31749"}
{"id":"2c88c8a6-d705-4857-8e6a-9bf7db453bff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10158788","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:e58e7d26-1d30-4db0-ba28-f6b3ddddeec1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5746","original_object":"UniProtKB:P25103"}
{"id":"512e3a89-3573-48ae-8237-28a0c3756f13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10458835","predicate":"biolink:affects","object":"NCBIGene:171163","sources":[{"id":"urn:uuid:57124f4f-a0ac-4379-bae7-14a4256a86fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4677","original_object":"UniProtKB:P31646"}
{"id":"0a28de11-915c-4f18-a53b-1aaed20b3d2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14372618","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:9d32d6d4-403c-45a5-8f03-c96ccf24e9b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9878","original_object":"UniProtKB:Q08493"}
{"id":"a5e9caea-3475-4f8b-af01-753d97930d86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:49157958-a09b-45ac-89e2-496256183e57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P35462"}
{"id":"b06b66e4-8cf5-4935-8569-0925caf8c9cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36511","predicate":"biolink:affects","object":"NCBIGene:1188","sources":[{"id":"urn:uuid:94d774f5-9f1b-4802-9e11-6615558df578","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4177","original_object":"UniProtKB:P51801"}
{"id":"73c599c7-5870-4755-a6f2-69ffc331d1d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:16532","sources":[{"id":"urn:uuid:678e37f6-159d-43e2-ad24-f54b067502d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:O54982"}
{"id":"f9cd67bc-6d97-4959-87c6-fb4eaf610654","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:667a705d-a027-460f-a891-373028d21c25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P08913"}
{"id":"f2a92726-43ea-4e3e-9105-c3c8f7cc79b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:7b52ee97-cea5-4926-8265-76779f126abc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:P56479"}
{"id":"b2e64ba0-7f43-4451-a530-e6ea2839b8ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146212008","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:f8578262-303d-4309-ad8e-1eaa69161780","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13457","original_object":"UniProtKB:Q13315"}
{"id":"9f0c4af6-0e6d-4c6a-828e-f3069181c1af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93509","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:51fcac82-795d-4fe5-9009-922e9a3b81e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13128","original_object":"UniProtKB:P18089"}
{"id":"300bb085-7f4c-489f-8b1e-9cdcd961fcda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145431","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:bacc8a6b-bdaa-464c-a279-449688e21c75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7046","original_object":"UniProtKB:O43570"}
{"id":"bc6eb2a3-3f6e-4838-998e-220757e10e4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:7220","sources":[{"id":"urn:uuid:1fcff848-07bf-429c-b79c-7f0a4cef12d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:P48995"}
{"id":"07800b68-16bc-4955-ac4a-9be6395266c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:4893694f-5606-4c64-94a9-02a712c22927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08913"}
{"id":"2e5099a2-d9a2-4fe3-b417-386fff76849b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:772a81ac-1057-441a-a1fc-19973e2a6462","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P31388"}
{"id":"a55c7123-bdee-40cb-961b-15605d218c5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:601027","predicate":"biolink:affects","object":"NCBIGene:5972","sources":[{"id":"urn:uuid:623799fa-2ce6-4d62-8795-aa3fd7939f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4812","original_object":"UniProtKB:P00797"}
{"id":"5eb4b35c-097a-4836-a910-a941daeb7331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1545","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:bf0e12eb-bad7-4960-b283-e844a599d011","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1545","original_object":"UniProtKB:Q63447"}
{"id":"cd0a375d-2e80-4009-a3a8-954cc50a9ccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58525066","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:48276b2b-68ab-4543-8308-9cfe36a32717","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9692","original_object":"UniProtKB:O00329"}
{"id":"301436e5-85c3-4171-a43e-46db34e5fbca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31073","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:05ad8026-0337-4e9c-af53-616cb94ccc2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4264","original_object":"UniProtKB:P42263"}
{"id":"c652a233-f975-47d4-8d3c-5277f4042a15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UT87RB8I1V","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:cbd231d6-c661-4473-894d-5daa79393179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12577","original_object":"UniProtKB:P08913"}
{"id":"0bda5699-da47-4ceb-917b-e9560c8b2ea6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13831","predicate":"biolink:affects","object":"NCBIGene:57104","sources":[{"id":"urn:uuid:dd4906f3-5a08-4883-8bfa-72b293a589a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13831","original_object":"UniProtKB:Q96AD5"}
{"id":"1e34d051-0471-4147-af26-b947f1fe8ace","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10699948","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:e25016be-c5ff-4b13-bbf4-b0ffed3bb4ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3099","original_object":"UniProtKB:Q02769"}
{"id":"015fd59d-e78b-46d0-829e-e7fbba78de8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134677","predicate":"biolink:affects","object":"NCBIGene:5150","sources":[{"id":"urn:uuid:957a1386-2d22-4b88-bd16-0c54a2f43b10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9151","original_object":"UniProtKB:Q13946"}
{"id":"2f2adab5-8ef1-4285-9ec7-1e6ab261dccb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16067787","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:dd7e0818-fa08-4a31-a07a-a478092a0777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6397","original_object":"UniProtKB:P31424"}
{"id":"6978cb2b-922e-427f-aa39-334f54de8e2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78540","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:82b9d45c-5eee-4c95-bf57-b9d0d1d7c43f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7372","original_object":"UniProtKB:Q08499"}
{"id":"8b9d0afa-2f5b-49c0-b00f-1b2156de19c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1819","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:df3e2a04-8371-4cc6-ab83-dfde62e9b0c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1819","original_object":"UniProtKB:Q03431"}
{"id":"6dc52067-ea0f-4e79-9348-7e16de7035cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030518","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:a190caae-a7d6-4f92-ac1d-7122f2d0f3d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10420","original_object":"UniProtKB:P35916"}
{"id":"4d8482ec-b179-454b-b4b4-c722bb3f326d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36259","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:96e0d27e-778c-49ad-96a5-9fed56362ad9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4548","original_object":"UniProtKB:Q9NYV8"}
{"id":"bd587fd3-2fa1-4022-9897-fde9da616fc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6111","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:89359a0b-65c6-45af-9d09-4361e2ab9cd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6111","original_object":"UniProtKB:P47211"}
{"id":"40fdf801-cb46-44ca-bd83-84286456227b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1791","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:d45292e4-c46a-4661-8e07-71bbe5a8dfa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1791","original_object":"UniProtKB:P49190"}
{"id":"dba78002-cdca-40df-ad31-53ee3737928a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8427","predicate":"biolink:affects","object":"NCBIGene:19","sources":[{"id":"urn:uuid:62a6b24e-c476-4901-bb54-5795214f6745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7277","original_object":"UniProtKB:O95477"}
{"id":"befc3292-81ee-4900-a1e9-fddaf5978372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754998","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:d3d89a45-5a03-4504-ba74-638775b2f9e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:843","original_object":"UniProtKB:P49682"}
{"id":"e1527fd3-4f40-417f-9b80-b17f41eba3ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135888","predicate":"biolink:affects","object":"NCBIGene:25639","sources":[{"id":"urn:uuid:775d8f28-4ddb-49b4-ad6a-ab6a6236c9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6783","original_object":"UniProtKB:Q62658"}
{"id":"06907b0a-53ff-4864-8b6c-4e8f9cd2c3fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:7bcb7ba3-f368-4593-8673-105ba51252f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P35560"}
{"id":"981c20ea-1977-4eb5-8401-01d1322348b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29132","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:36855fad-93d7-42a1-bfa5-b71c524f02aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6299","original_object":"UniProtKB:Q6RI86"}
{"id":"0eab6eb0-9d5d-4f74-bab3-a8f77f5f3795","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:6c70b51e-fa88-4534-b999-184d153c1896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P34995"}
{"id":"c5629873-6223-426d-ad30-405b3265ffad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:85473438","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:fa67beda-e1bb-445b-95c8-a4b092df2586","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10291","original_object":"UniProtKB:Q9UL62"}
{"id":"860a8745-6282-4e2e-9b86-6f60dee6da5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519693","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:ed131266-a43b-4ba0-a7b0-ba24f6586247","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8148","original_object":"UniProtKB:P51813"}
{"id":"37b2f0ad-5019-4fef-97ae-832265f354f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45II35329V","predicate":"biolink:affects","object":"NCBIGene:27035","sources":[{"id":"urn:uuid:7449e1d4-a17b-4013-b8d6-92b876741667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9932","original_object":"UniProtKB:Q9Y5S8"}
{"id":"efc70557-a6fe-4deb-8a63-b0a38e2140d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44328226","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:1bd6ab0e-4fd4-47f2-b01b-9747f3c8dd02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1557","original_object":"UniProtKB:P49683"}
{"id":"9f1daad9-50f8-4cc2-8e00-a3e37003787c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:49fc5d1a-83fd-4708-821a-24022ccced2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:P23416"}
{"id":"cda753ad-69bd-4543-a563-b857ce3416ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133021","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:c37c036c-c790-4634-85e9-b33b468798b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8318","original_object":"UniProtKB:Q07817"}
{"id":"ff0ffd5c-ff7f-4783-a33c-f9643873d72f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44265059","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:810f5d4d-e617-4922-9c53-13316beec129","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1539","original_object":"UniProtKB:P49146"}
{"id":"cda0d210-c9dd-48a2-ad41-cf8ea3dab611","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10506880","predicate":"biolink:affects","object":"NCBIGene:12801","sources":[{"id":"urn:uuid:854f82e7-5e53-4e2a-832c-e29ec2d86c5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:744","original_object":"UniProtKB:P47746"}
{"id":"65a018f8-cf96-4a59-ab1e-7c722a09b9b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68060125","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:6b5ee149-b46f-4894-8fd7-4b5a116f040a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8938","original_object":"UniProtKB:Q13153"}
{"id":"42ea1c07-0958-4272-a129-e49242a0e69d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17675","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:3834dd8e-1c1c-461b-9803-0069d956e4a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10209","original_object":"UniProtKB:P08684"}
{"id":"2ecc1b00-b51e-40a8-8c15-bbd429441a98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366965","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:0c52dec6-0f3f-4db1-a7dd-6fd04f7f61c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11732","original_object":"UniProtKB:Q13315"}
{"id":"3d4ab1fb-1ca5-4c91-be80-667e163a80bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5330548","predicate":"biolink:affects","object":"NCBIGene:18595","sources":[{"id":"urn:uuid:cdd99bc7-31c9-49d7-b9b5-1e0d3e598c43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6018","original_object":"UniProtKB:P26618"}
{"id":"e554dae2-7ed2-4c00-bb17-c87836531d7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:2858c80d-894d-410c-8ae1-1f43da9fc3ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P43114"}
{"id":"fc5146e4-abbd-472b-8a76-678ca82b1f60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135946","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:e42f6102-2597-473f-9fd9-f3c59bae4114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:864","original_object":"UniProtKB:P32239"}
{"id":"d74fc4b6-a636-47d0-bb11-8b45cb49723b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188719","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:f9b9094a-4a8f-4c1d-be62-87ca156eb54e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8376","original_object":"UniProtKB:P31639"}
{"id":"8d53a427-5589-4412-b324-d5d32cb3f083","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:09d695a2-7af0-4ba4-9bbc-b9f83726ccb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P34969"}
{"id":"0dc66bfe-0078-4d06-b0b3-be12dd13445a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175443","predicate":"biolink:affects","object":"NCBIGene:259286","sources":[{"id":"urn:uuid:4a014f03-c217-4561-92ff-e794e2223f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12422","original_object":"UniProtKB:P59535"}
{"id":"49ff1276-4828-473a-87d4-94022db47a51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996522","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:5bdf6ac9-fc06-4cee-bc21-07a86867ee50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10585","original_object":"UniProtKB:P41597"}
{"id":"bb4a698d-4faa-485c-b3ca-dc505b28fffe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16958","predicate":"biolink:affects","object":"NCBIGene:211578","sources":[{"id":"urn:uuid:0db7bc75-e90b-4e5e-8c07-2b5aa699e89a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2365","original_object":"UniProtKB:Q91ZB8"}
{"id":"85c61bbf-0d8b-42c1-80e9-3333b9f2bafc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57381425","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:4ee10648-7836-4a1d-8649-f3213871f488","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11120","original_object":"UniProtKB:O15379"}
{"id":"1d408c3b-9991-4788-9948-aa68e2ff6227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18139","predicate":"biolink:affects","object":"NCBIGene:215854","sources":[{"id":"urn:uuid:1de71bb6-c9bc-4af1-88b6-327bfdebc237","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5521","original_object":"UniProtKB:Q5QD14"}
{"id":"ab59a7e2-37f3-4bf7-92bd-316ed4646f6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2155","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:1961178f-c5ac-445c-bd85-4da213974277","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2155","original_object":"UniProtKB:Q9UKP6"}
{"id":"328b18a6-e247-459f-a6e7-d722fe57581f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:47b9b723-1903-4070-8663-f6d301c9368f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q9UQD0"}
{"id":"dd81bf56-35ff-47be-b7f9-23486e37734c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138377580","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:9435773d-3b86-4b51-af18-5eb2030cffa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12530","original_object":"UniProtKB:Q9HCX4"}
{"id":"224ad604-23d0-4c93-9013-08289e66a2be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9963005","predicate":"biolink:affects","object":"NCBIGene:18389","sources":[{"id":"urn:uuid:c3d4fb07-1c2c-4d86-a18d-000662667aec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1679","original_object":"UniProtKB:P35377"}
{"id":"3aaf5cff-a36a-48a1-b960-5440e45b2ea6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:82bc5331-8d3b-4784-932b-bdba4739ea96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:O95136"}
{"id":"54dca725-757a-4155-b1d3-4a9dec1236f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6103","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:5606ff45-82f8-425c-86ba-4e80ff97c66e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6103","original_object":"UniProtKB:P47211"}
{"id":"3f5e802f-116c-4322-aac4-4a11e15d62a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60152613","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:a45c5384-5a6d-462a-883c-c41448cb74e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13942","original_object":"UniProtKB:P15056"}
{"id":"006076c0-87a5-4b6c-a1de-b79e1d5d7b23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10044321","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:310fb242-a4bc-4fce-b5b7-2ec4806b5d11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5140","original_object":"UniProtKB:P08253"}
{"id":"e0eb1382-173c-43e1-b5dd-eef2b8600ad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92360","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:1f30ab18-9e08-47d2-9c5d-60f234f0d764","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:165","original_object":"UniProtKB:P41595"}
{"id":"36e6e739-c0b6-4897-9263-e8ee779ba38a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1544","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:c13a801d-5872-4922-8e0b-082cfa7ae026","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1544","original_object":"UniProtKB:P49146"}
{"id":"98d3af1d-8442-46a9-823c-bff528ee0947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889212","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:85dee15c-99b7-4fae-b3fd-8cc200dd662f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4260","original_object":"UniProtKB:Q12879"}
{"id":"87495d1e-d1b3-44c1-82b7-fd9b99924596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG8BT6T9MB","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:c8b23453-7e1a-402d-8fe1-3c12ba4206fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5993","original_object":"UniProtKB:P52333"}
{"id":"4aa9da79-3d36-4ba0-b3c1-9c70a262fd03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035449","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:7b72920f-ec39-478d-9d7e-6661014d8a05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:638","original_object":"UniProtKB:P30411"}
{"id":"b82d683d-43e5-4cee-860d-ecaebc705b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93326","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:ab3b8bea-4f7e-4bef-8743-958b65fdb5f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:5446","original_object":"UniProtKB:P31424"}
{"id":"2247bc1c-8782-40ec-ac4e-be24aabc6a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71890885","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:88ed1c01-1f7d-4113-a941-7e52bdce0e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12663","original_object":"UniProtKB:Q9NRM7"}
{"id":"41cd70f2-1b3f-4f93-a157-72232cc102d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2914","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:39efd2c3-f06d-4b95-a416-972050b91b89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9537","original_object":"UniProtKB:P36544"}
{"id":"ac9c5f61-6fe5-4873-960a-76ba83001944","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10434","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:3b7c6467-2d88-4b7d-ae46-500dd51ed299","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10434","original_object":"UniProtKB:P00915"}
{"id":"1bb074fb-f3b0-4854-9127-05696473e127","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5485208","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:f1ac2e12-68ba-4ac3-9c73-c4dccdcb1d69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1677","original_object":"UniProtKB:P42866"}
{"id":"cbe5a176-3d6d-4e46-a42b-2141621031aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:0e0388d9-41d0-4875-8258-5ff0683969ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1641","original_object":"UniProtKB:P34975"}
{"id":"da2517bf-ea51-4ae0-a57b-99a99a51115f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:613c1ae0-4ef0-4a26-a19f-faf38f8c6419","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P47898"}
{"id":"ac739585-d793-486c-b396-cc272059960b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132000148","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:e6d0945e-4cc2-4ecf-98ab-7f6acd2221de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11555","original_object":"UniProtKB:Q86WV6"}
{"id":"926047b2-2d99-4d02-931e-2192f1753325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567102","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:323c1dcf-7382-4064-9206-13926f28cd6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12661","original_object":"UniProtKB:P36507"}
{"id":"80d3b051-7e4f-4e8b-852a-f4d3a7e6546e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82644","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:25fed504-166f-4d3c-9a79-a6d47cf2fb9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10455","original_object":"UniProtKB:P07550"}
{"id":"ab4c5b85-d31c-4a19-aaae-a8515f215ee8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:c77607f9-71c3-49b2-92a6-0e8ba2665cd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:O95835"}
{"id":"2efb7cbd-ed2d-4cfc-bf76-f11f410b7389","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081968","predicate":"biolink:affects","object":"NCBIGene:65030","sources":[{"id":"urn:uuid:61567713-da2d-49e1-b208-c43d699ca44b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9897","original_object":"UniProtKB:P80299"}
{"id":"7722c43c-f103-43f8-9569-a38fa1e3287b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73211886","predicate":"biolink:affects","object":"NCBIGene:2863","sources":[{"id":"urn:uuid:6f393b2d-b946-437a-a5c1-34c0e1f45e59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7800","original_object":"UniProtKB:O43194"}
{"id":"faf9a410-57ab-4180-bb09-a9d80e302846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:5d099edf-fa3e-4660-b026-89d290a52d01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P08172"}
{"id":"6dceba33-8d93-491c-9293-b48915b16831","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91450","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:877f90e7-7781-4795-979c-2d9f284c35bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7933","original_object":"UniProtKB:P42336"}
{"id":"bfb2923a-c886-49d4-929a-dae5a28819b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:6580","sources":[{"id":"urn:uuid:c836d552-021a-48f1-8111-8145a4ce2456","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:O15245"}
{"id":"cc3599ac-552f-4da5-bb64-73db236dbec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11956150","predicate":"biolink:affects","object":"NCBIGene:23770","sources":[{"id":"urn:uuid:1438dd08-6a51-4200-94b7-73589f83e780","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11484","original_object":"UniProtKB:Q14318"}
{"id":"000f9559-7016-4d94-bb65-5351831ed46e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VWJ2QVH41J","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:fd98cec6-0de8-424b-a9ab-7109a5ca6a49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1856","original_object":"UniProtKB:P25105"}
{"id":"25766ae8-eb1e-4c93-a4e7-4bde286259fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34159","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:91e9fffc-d3ad-4358-842b-8085a36983a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2692","original_object":"UniProtKB:P37231"}
{"id":"bdc143fc-dc02-4183-9396-d1eec400660a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:10188","sources":[{"id":"urn:uuid:6dc85b91-0fc7-411f-a380-d02f2b588966","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:Q07912"}
{"id":"f6314ec0-ee5f-4bea-9140-e0ec06261722","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155818902","predicate":"biolink:affects","object":"NCBIGene:823","sources":[{"id":"urn:uuid:3c4f5c03-b2d1-4bf0-929d-132d50f91203","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11701","original_object":"UniProtKB:P07384"}
{"id":"8d702191-6834-4f68-ae53-d258a092f5dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110176","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:d14eda50-c3f2-4973-b244-e4952b29bf82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3264","original_object":"UniProtKB:P20309"}
{"id":"d7cf9be6-ce2c-4a79-bf9b-d8a2bd200d4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:a5bfbbfa-54ba-4c4b-aa70-4d987871f265","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P47900"}
{"id":"fb70dcca-f305-4879-a151-7c81cfd9db03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:684","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:a0b2671f-f547-4364-b132-2ad304ea5a21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:684","original_object":"UniProtKB:P30988"}
{"id":"90f73440-54e5-4b71-8153-4e2f127c84ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71717297","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:9a57a38b-4b3f-4794-b43a-f3e714ee21e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6683","original_object":"UniProtKB:Q99720"}
{"id":"34e097ad-df4b-49f1-8fa0-7064ebf52b1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2017","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:483782e5-a1cc-4eda-9f01-687241bfbb1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2017","original_object":"UniProtKB:P30935"}
{"id":"3efea159-61af-42cb-a977-7ee59110aa14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6552","predicate":"biolink:affects","object":"NCBIGene:2155","sources":[{"id":"urn:uuid:cbe2d538-8f98-40d7-9d58-6209b974488c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6552","original_object":"UniProtKB:P08709"}
{"id":"4ef5f83e-f928-4a35-bc68-760255727b8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45353","predicate":"biolink:affects","object":"NCBIGene:24590","sources":[{"id":"urn:uuid:07c6bf1a-b530-4dff-b286-db304adf5aae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11653","original_object":"UniProtKB:P07861"}
{"id":"963e1550-fd14-43fd-a269-b1959f41c710","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8S5G34WY1","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:98c3c1e9-742b-4c15-bfed-9ba23c65f102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11024","original_object":"UniProtKB:O88536"}
{"id":"bdc92df1-c560-4690-b2c5-6a4e2d4e6495","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3081333","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:35ec49ae-b1cc-42ba-9afc-ce20698a0e0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1010","original_object":"UniProtKB:P24530"}
{"id":"c1f8b04e-407e-446b-a111-1e2dd5ad7803","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:992293","predicate":"biolink:affects","object":"NCBIGene:6566","sources":[{"id":"urn:uuid:9da393ab-bae9-44ba-a2d3-2383419b6b1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10405","original_object":"UniProtKB:P53985"}
{"id":"e9839e75-8d9e-44b0-8d6f-2880d62d9eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5138","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:e058d314-bc5a-4659-803f-1a1593338b49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7189","original_object":"UniProtKB:P31645"}
{"id":"f3ecbc22-7b7c-4bf3-b6ac-eecddc766cfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XX8E5WP7FS","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:89272e24-24d0-4a9e-be67-67a4353511eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10257","original_object":"UniProtKB:P07333"}
{"id":"88bf2aa7-8c3e-4dcf-8510-bf4d7539079d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553157","predicate":"biolink:affects","object":"NCBIGene:111","sources":[{"id":"urn:uuid:3ec9fa08-a331-463b-bf44-1def9bc002be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10215","original_object":"UniProtKB:O95622"}
{"id":"5399ac3c-a489-486f-b96d-9775c5d3d264","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993647","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:ce8882cc-6745-4e38-ba10-30e545639889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12503","original_object":"UniProtKB:Q8WXD0"}
{"id":"d5ed85ba-cf8b-4f16-9fb9-5baefe0806b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46897162","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:7b7d57c8-c440-42f4-8c6e-0cd56ed59d82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8501","original_object":"UniProtKB:P25025"}
{"id":"91cd6ac6-c15f-4579-9576-bec8034dca00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126970684","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:df5d32c9-ca28-42c6-8f82-3bcbd85d6744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9577","original_object":"UniProtKB:Q9UHD2"}
{"id":"178157c7-5408-4b02-a030-ef7db64c148c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F89KMM7TE2","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:84c9b73b-8284-4ee2-9a97-1f9b26aa5a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8037","original_object":"UniProtKB:Q13464"}
{"id":"f920cf1a-a0a1-4a51-a47f-1fe01542080b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177849","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:d7be5da0-fbf9-41f8-ad11-d54827750bf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10408","original_object":"UniProtKB:Q01726"}
{"id":"84d431e3-0e34-4646-bc1f-d56ea26f8c70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:e0fbebda-5586-40e2-87aa-7aff691c5682","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P28335"}
{"id":"a30c659b-1f27-406d-af51-495f804aad82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:8d067082-149e-4dcd-a72c-f56f907cba50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q13177"}
{"id":"31940ab7-0237-4071-8226-c6dfbe287540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166633833","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:40aeb57d-3475-4d0b-b7cc-4a09c1b6d950","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12439","original_object":"UniProtKB:O43613"}
{"id":"b8dc5277-8c1a-4c7a-8ed6-34173b022a74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3964","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:3e78aa10-0cf3-42ba-8114-9f68c5f0e766","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3964","original_object":"UniProtKB:Q9UGM1"}
{"id":"b2a82f45-d71e-464f-aabf-4ca1151c2f18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5282545","predicate":"biolink:affects","object":"NCBIGene:6566","sources":[{"id":"urn:uuid:37ebc78f-03c3-4d01-b582-a48d9a7bb61d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8813","original_object":"UniProtKB:P53985"}
{"id":"5ab5a8f1-482d-4d75-a905-f95dbf631dc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:35f8a97c-5d95-4167-aa51-851daa7a71bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:P30542"}
{"id":"82bcc160-3743-4366-882c-4d55f6e66ef0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139390026","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:a32f8258-b133-424a-ae15-e335d58dd5d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12078","original_object":"UniProtKB:P11802"}
{"id":"682eb1a7-efa6-4549-95a6-c561972cd200","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18152","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:aec9b02c-5b8b-4123-9e68-ebf6fd70d3c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13074","original_object":"UniProtKB:Q16678"}
{"id":"dea78aca-0918-4597-a1a5-97b5390c1a1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131158","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:c0926220-2304-432c-9eec-26993b3e77af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6978","original_object":"UniProtKB:P49768"}
{"id":"de495f31-f3d0-4191-8131-08dfa0a1717b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3892","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:a17e741b-53db-44ca-8076-471be4f0f0c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3633","original_object":"UniProtKB:P41968"}
{"id":"7b17191b-775f-474a-bf4d-1170f06e0fc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5353264","predicate":"biolink:affects","object":"NCBIGene:22064","sources":[{"id":"urn:uuid:e2982534-4576-46c7-8ef3-818c6577c815","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2436","original_object":"UniProtKB:Q9R244"}
{"id":"3bd82e21-9c03-441b-9bc1-239ee84ceb5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229226","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:36ad42a8-34cd-41cd-ada8-78187a572bdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8312","original_object":"UniProtKB:P31639"}
{"id":"203dc999-0744-44cc-b87f-c3d6c50cf888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311226","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:5a7d230a-228c-46ae-99f8-d7992831bf3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1962","original_object":"UniProtKB:P43119"}
{"id":"9a6e175d-a086-4a6a-bfd6-ff3a229b0cea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67119","predicate":"biolink:affects","object":"NCBIGene:171108","sources":[{"id":"urn:uuid:846b722b-35f8-499d-88e9-3787b2cf6850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1782","original_object":"UniProtKB:O35881"}
{"id":"5a1019c6-4183-482a-a387-3794b7f5b0d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16118","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:10d8a177-5c6e-4e10-9843-180474d79467","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11353","original_object":"UniProtKB:Q16678"}
{"id":"bd42710b-2e84-49b0-a59d-b95bfd56c37f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10470232","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:c02aa886-f08a-4d56-8dc2-3a244505d184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6336","original_object":"UniProtKB:Q13255"}
{"id":"b2c36121-31d6-47bc-add1-5b8b540e2f2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E00MVC7O57","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:4abf7a02-e048-44b7-9d2d-e8cd2dc11464","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7861","original_object":"UniProtKB:P43235"}
{"id":"c09cdd67-a82c-4137-bf11-5f97c2a9c6c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:ffb2055d-11d9-4f20-bbfb-2f7c3d7f5aa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P06241"}
{"id":"ba5db1bd-5e52-4a10-935d-dea36128beb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3552","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:33b671f8-8bf3-4854-98ba-257bebd19ce3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3552","original_object":"UniProtKB:P32238"}
{"id":"56badee2-d480-47b3-9438-36ed773d6c97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RU48RF5PFC","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:28d20169-00f7-48f1-a218-0f8b2e0bfa67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6544","original_object":"UniProtKB:P22894"}
{"id":"8936281c-dbaf-40ad-8476-31317e694b5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46901383","predicate":"biolink:affects","object":"NCBIGene:23683","sources":[{"id":"urn:uuid:df624283-32a8-40b1-9f15-90a2a21f0f17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9370","original_object":"UniProtKB:O94806"}
{"id":"67414093-caaa-4d10-91f0-d1e98d813a72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177643","predicate":"biolink:affects","object":"NCBIGene:25652","sources":[{"id":"urn:uuid:3c6f6485-fee8-4674-9a48-b544bcc89224","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1956","original_object":"UniProtKB:P43118"}
{"id":"b1656883-7a2f-46cf-8df4-309802f51ff1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:40ef70dc-d731-4396-b197-3d6c15e98bdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P07333"}
{"id":"b0e3847b-2572-49f9-be91-b73abec9888c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83501","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:47401e7d-aaf8-42c8-b4f1-7692027510bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12460","original_object":"UniProtKB:P59537"}
{"id":"c5eda8f0-a055-4686-93ca-4325f1699df3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6532","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:05aa05e3-cad2-4fd5-85f5-71e99c9a5e99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7215","original_object":"UniProtKB:P35372"}
{"id":"e35cdb9b-6bb5-4f61-aafe-66687db45379","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827386","predicate":"biolink:affects","object":"NCBIGene:51702","sources":[{"id":"urn:uuid:3332acfa-68d7-45b7-952f-11c73b6a86c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8684","original_object":"UniProtKB:Q9ULW8"}
{"id":"4ae25099-ec40-4564-8944-57fefe05b29e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847721","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:1c40c5ca-8a37-40ba-ae37-bad7b7d6087f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:906","original_object":"UniProtKB:P30553"}
{"id":"7083ebf1-8880-42b0-8495-2d189d748c9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5988","predicate":"biolink:affects","object":"NCBIGene:5610","sources":[{"id":"urn:uuid:ef0fefed-af4c-40aa-8905-86f3b3d771a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5988","original_object":"UniProtKB:P19525"}
{"id":"4834c601-cbb6-4872-b8b7-e8932b4e9b9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817509","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:c2a5d3a8-151e-4370-b004-cd7975318d8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11350","original_object":"UniProtKB:P04798"}
{"id":"144c9192-2431-4a31-98ea-b54b3c3e6338","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92553","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:0334c370-2a8c-4cda-adf8-0540bd15ed25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3444","original_object":"UniProtKB:P37231"}
{"id":"edb074c6-9b1a-4884-b118-61b4809caeb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32168","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:c239abe1-0ad5-4fa4-9234-3b98cac938c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5501","original_object":"UniProtKB:O43570"}
{"id":"4800d429-7306-4fec-a29a-4000ea7e58f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167820262","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:8d84baaa-6833-48f7-8e70-4c923cbd7cee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12741","original_object":"UniProtKB:P0DTD8"}
{"id":"ddc706e1-354d-4b0d-82bc-890239cd2f51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90620","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:df2b9483-9551-4141-aca2-8497be1e8e60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5705","original_object":"UniProtKB:P35916"}
{"id":"9ed4c83c-e188-4665-b61a-20dfddf1af5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8966","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:01b850ff-197a-4feb-bc65-c809bcfe4518","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8966","original_object":"UniProtKB:P08581"}
{"id":"d9e6c75b-58f6-400b-9447-58702ca9151c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:f540143d-0e7e-4528-9db9-b4fef10bd930","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P09619"}
{"id":"29b01079-b087-4cbf-87e0-43370592643d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2632","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:5f1eff10-4028-439b-949e-e6da6e6727da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2632","original_object":"UniProtKB:Q9UQD0"}
{"id":"ae856bb1-8a2b-4d67-8182-64fbaf0847d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17158","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:f89e9e04-c36a-4ad6-ada1-3d112a899451","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6303","original_object":"UniProtKB:O75762"}
{"id":"1408908c-a3ce-4e72-9fa8-a085cc5fa35c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11636757","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:37c6ad91-88eb-4d65-a534-5440d769a02b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1761","original_object":"UniProtKB:Q96G91"}
{"id":"7d83b960-bc57-469b-84a7-5969cd6efe9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030528","predicate":"biolink:affects","object":"NCBIGene:3694","sources":[{"id":"urn:uuid:67f02db1-05e2-4a11-867c-1b35adcb43d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10450","original_object":"UniProtKB:P18564"}
{"id":"a4e99301-fdc6-47be-b4cb-d7ef7ff46790","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23725177","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:84c7d5de-30ae-492b-b96d-75acc94742f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11598","original_object":"UniProtKB:P51681"}
{"id":"38112f9f-f8a8-4db6-838e-8a7b651e6a91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10389239","predicate":"biolink:affects","object":"NCBIGene:8550","sources":[{"id":"urn:uuid:76c96fcf-73eb-466c-8a7d-146704ad69bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8177","original_object":"UniProtKB:Q8IW41"}
{"id":"b00ad528-9c25-4d82-bd44-36cd1b7eae32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17985","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:5d5eb005-012c-4ce9-b958-82eab6bf4f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1718","original_object":"UniProtKB:P47900"}
{"id":"f031ba8c-ea65-4b13-83a6-6069e083e45b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2063","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:f2fb3aab-5f59-4ed8-9e88-502ec94e4074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2063","original_object":"UniProtKB:P30874"}
{"id":"2eebda4f-432c-481d-ae8c-ef7ada8eea43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:152231544","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:b7c6e802-491b-4ee8-a195-34e6d1ed48f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13221","original_object":"UniProtKB:P29597"}
{"id":"71ea3e6a-7f98-4a6f-b932-07c511d8b9a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1285","predicate":"biolink:affects","object":"NCBIGene:78976","sources":[{"id":"urn:uuid:765fe613-857a-4484-97b3-6ba3d8ed875a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1285","original_object":"UniProtKB:Q924U1"}
{"id":"2ad3ee41-274a-40a0-9805-c57eeae0f246","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65346","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:cc15f302-c74e-47a3-8bba-073dc0e8df00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7449","original_object":"UniProtKB:P08912"}
{"id":"8443e466-9669-404b-bbbf-b9f2b14c463c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:2be5dd57-e7f3-4512-bce3-7e8d27190022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q8WUI4"}
{"id":"8d37300a-7e55-4692-a7ae-7f72a5e1f334","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31515","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:8fa6151b-11f5-4fe1-9875-8cec2d5787ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:965","original_object":"UniProtKB:P61169"}
{"id":"f3fd2fdc-c09c-469a-9f97-9a37cd40f4d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93705","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:cf866b5f-083e-44f0-a833-631ff5a611b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6040","original_object":"UniProtKB:Q16539"}
{"id":"41252c0d-7628-4006-b622-8d0bdb68d30c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:f7ab9870-6fac-4d16-b3fe-24251dc5cab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P42680"}
{"id":"90ba935d-5bd8-4147-8a91-200a96f6fb7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:5e8c19d0-d8cd-4620-858d-00288683ac98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P08581"}
{"id":"f3ebd445-1188-47be-8ae3-52ea46ea8930","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6108","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:d2ab01d1-1784-40d6-b599-9a10e6924bb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6108","original_object":"UniProtKB:O43603"}
{"id":"f1fc297f-f4ba-4485-823b-e81a3e698cd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817404","predicate":"biolink:affects","object":"NCBIGene:83567","sources":[{"id":"urn:uuid:bd679b66-9afc-4828-8d82-9db1e9cf145d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1295","original_object":"UniProtKB:P97639"}
{"id":"466465dd-f9eb-41a6-b11a-64bccfafd18e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2539","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:068d9daf-2c37-4bf1-b57c-fb131c1add86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2539","original_object":"UniProtKB:P54282"}
{"id":"ab6359a8-5e68-4f31-8ee9-b1e6dad2f448","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135947","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:37f3382e-09c4-4b91-acf2-47862996f3a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7355","original_object":"UniProtKB:P03372"}
{"id":"8efb77e6-2a24-4f4d-8a37-6dc6ac54a716","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80238","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:cba52193-d4a5-4ea6-83c6-6d8462f240af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:639","original_object":"UniProtKB:P97583"}
{"id":"1faf5e97-745e-4b2f-b256-5b18d80022c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21779964","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:968183c1-e2be-4b54-b315-5be4d482ac78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1604","original_object":"UniProtKB:P35372"}
{"id":"c553f057-dda0-43bb-990e-0624bf6dd4fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130345110","predicate":"biolink:affects","object":"NCBIGene:4017","sources":[{"id":"urn:uuid:0d35a5eb-1fa1-4611-ae0a-815d51e1046c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10486","original_object":"UniProtKB:Q9Y4K0"}
{"id":"30300226-a38b-4708-91b9-a33c26702a6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:2870a95f-3511-48b5-8042-a3e48ff67975","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P21917"}
{"id":"907e30f5-0846-49d9-b1b6-f47059ca030d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:2381b89e-9922-4cdf-8e68-3cf9c83cb184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P28335"}
{"id":"ee8fe4ae-37c4-41e5-9caf-89575a5e5aaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37850","predicate":"biolink:affects","object":"NCBIGene:3709","sources":[{"id":"urn:uuid:5727b3e6-857e-4dab-867a-144ba329ab7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2459","original_object":"UniProtKB:Q14571"}
{"id":"428fddc2-1b50-4b82-a9d5-14630a70dc7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1094","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:085965a9-5c4b-4513-8e59-a85d71b8756b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1094","original_object":"UniProtKB:O08725"}
{"id":"915f1af7-6e49-4ec5-bbc1-91db0fd1ede1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135123","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:cadd3628-6bf5-40f6-b348-b7f8516835ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:550","original_object":"UniProtKB:P13945"}
{"id":"4df52a44-e45b-446a-a85e-7f710edeb81a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11531145","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:96b5ff53-b839-42d6-8331-1ce534bc0a35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5589","original_object":"UniProtKB:Q5NUL3"}
{"id":"35d13b56-4056-437f-99be-3d314764f94f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:94ed3494-4c7b-49cf-a987-3e8978fd2437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:P56696"}
{"id":"eaecebd4-4dd3-466d-afe7-8797709d01fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1490","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:b4eed73c-774f-4c1c-8018-d84f7f239ef6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1490","original_object":"UniProtKB:Q6W5P4"}
{"id":"d1aa0dfe-502e-4900-b710-544013d07544","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68579","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:8c2efd2e-fe81-493e-8e4c-4dd7a37cc4b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6388","original_object":"UniProtKB:P00742"}
{"id":"df400b46-0fc0-4d43-9e10-71ce3bb99323","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9738","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:0f5e4be2-5905-4aff-89a4-f610323cb1d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7317","original_object":"UniProtKB:P23975"}
{"id":"da8fcd5f-1000-4d07-9455-66a6367b40cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:977bf966-c6ed-4309-8b14-b80d2951e837","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:P23415"}
{"id":"a3ee0a9f-390a-4d57-b094-3fdab13ccab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184048","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:b03d3145-437b-490e-9aee-f8937d21def2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1448","original_object":"UniProtKB:O43193"}
{"id":"a39d3534-96cb-4397-89e5-4b107634d443","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131345","predicate":"biolink:affects","object":"UniProtKB:P27732","sources":[{"id":"urn:uuid:0d9db538-c084-4ab8-be7f-ee31a861d54a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2511","original_object":"UniProtKB:P27732"}
{"id":"a88abf04-6a82-4daf-9965-4fb89c727cc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9123","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:565362f1-1713-444d-8842-12550d0fabd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4798","original_object":"UniProtKB:P31645"}
{"id":"3d683e17-88d2-4c12-99f1-32e0d723ef4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92318","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:4956bcfe-6549-4584-b02c-220a04a5ec73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5558","original_object":"UniProtKB:Q9Y2T6"}
{"id":"3cf0f34c-7fac-4f41-a353-a1ace24f6547","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31684","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:63e4620a-4db1-4641-949a-b4ff27068219","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7399","original_object":"UniProtKB:O76074"}
{"id":"5c4016ec-0ce3-4f0c-beb8-546397b3a73a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311003","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:a918a102-c3b8-4f53-a1fa-05eeac3d42cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1600","original_object":"UniProtKB:P32300"}
{"id":"66c89281-a0a7-452f-935d-9a978d132b0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368938","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:764cf2b4-8fd0-4167-874a-f4ec82509608","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12216","original_object":"UniProtKB:P31751"}
{"id":"a3a3d312-59f0-4845-aece-22573ff9454e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67119","predicate":"biolink:affects","object":"NCBIGene:140795","sources":[{"id":"urn:uuid:1ed0e74a-5e45-473e-8945-a40d98e07771","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1782","original_object":"UniProtKB:Q9ESG6"}
{"id":"90c6f898-bd59-428e-bd72-aa82bbe97ad7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449051","predicate":"biolink:affects","object":"NCBIGene:5328","sources":[{"id":"urn:uuid:a7f42d63-ebdc-45ee-9d04-bdac19b93ace","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6545","original_object":"UniProtKB:P00749"}
{"id":"b8e28445-93a0-44cb-a17e-debd3ed96553","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10806465","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:8dc5e59a-777a-4d2e-8304-800eee51e8e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:396","original_object":"UniProtKB:P25099"}
{"id":"bb16b065-da33-4e1a-bb17-36d4e9868c63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2AD53WQ2CX","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:0228bbd5-5f9c-4481-bdb9-05746745c747","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7680","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"11a632eb-67d4-4260-81e1-41f3171e4047","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93645","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:5385dbb7-f915-4a94-81e2-cc8a69d6e86d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3304","original_object":"UniProtKB:P21728"}
{"id":"dd5d7fab-971d-4186-b23d-cc478a080fb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:e91e351a-ea3c-446c-9759-b366cba259f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P21918"}
{"id":"25c7b8ff-6464-49b9-8b6b-30475c6aa0da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34461","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:36e0247f-4587-4e68-a9e8-20720cf5a376","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4321","original_object":"UniProtKB:P31644"}
{"id":"5b77a06d-b89d-47e6-88a1-991295df84df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34076","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:f6dfe534-a6fc-4b23-9396-c4913ee49d38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2314","original_object":"UniProtKB:Q92952"}
{"id":"9c17f18b-86e3-465b-a97c-e97b0c67ab39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231602","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:30337ffa-a62a-4035-a255-fffe783b4292","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7942","original_object":"UniProtKB:P36507"}
{"id":"f505db9a-8dcf-45ea-b8ef-c0f24a999f38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PT4P8MJP8L","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:ea7c046d-dc43-40d1-bf0e-96cc64c039b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13372","original_object":"UniProtKB:P21728"}
{"id":"da70aa11-c340-4eea-b8a8-77cbbfbfe6b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:763","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:29c42dd6-5cdb-4173-bd07-2db68e45bdb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:763","original_object":"UniProtKB:P51681"}
{"id":"88afbe7d-94e5-441a-886c-16b82016643c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:100978427","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:4cec33d4-173b-452b-a5f3-938d5c2bf774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:645","original_object":"UniProtKB:P46663"}
{"id":"0fc85aca-7eb7-4577-b813-09b60a9de9ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:615","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:3dbf16a4-c783-4692-b69c-476e6eca2004","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:615","original_object":"UniProtKB:P52500"}
{"id":"c11450de-0451-4d0a-ada4-6b65cadb4d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1527","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:2378649d-eb4a-4597-8bb9-c7cb21598831","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1527","original_object":"UniProtKB:P21555"}
{"id":"c2155019-1162-416f-ab64-799151cd4e5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37100","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:9ee3653c-298e-461a-9d13-b96654b10f02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2933","original_object":"UniProtKB:P49019"}
{"id":"992dc8f3-7446-43cb-96ff-34613b3c63cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:d81fbe3e-8ba0-412f-816f-b2b5f650357a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:Q14831"}
{"id":"bd892d91-ab93-4043-871c-e657057db43d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:1add92a9-372d-47fa-b241-7eeed9a8d4d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P25100"}
{"id":"4952cce7-f00e-4660-9b22-cf39bb5e0d79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44232532","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:2e33c5fa-c19c-4869-b885-5d96ff5e967f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10274","original_object":"UniProtKB:Q6RI86"}
{"id":"9cbf96c4-a339-46df-b881-f982a304ee45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817480","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:07634184-d7dc-47e2-b9d3-ccae50ce9d93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6091","original_object":"UniProtKB:P47211"}
{"id":"4de6f01e-23da-42c5-bf61-f084485b5f96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40823","predicate":"biolink:affects","object":"NCBIGene:1491","sources":[{"id":"urn:uuid:01303a78-a59a-4cc5-b648-4b0fe88dd1f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5136","original_object":"UniProtKB:P32929"}
{"id":"aaf0080c-d8ca-44fe-a23e-04103383d4dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:10fa265d-38e2-43c2-a921-bbc3cfc0369f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P16234"}
{"id":"3cce0c5f-4f58-4469-afba-a7e43082904c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39867","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:fb4d7771-626b-473a-8e10-f09cacbe80b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7009","original_object":"UniProtKB:Q13547"}
{"id":"9c5e2c77-6c0c-4451-a16e-1314078ec34c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136666","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:23c7fdb9-b8dc-4a4b-b1dd-24cc537ee896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13862","original_object":"UniProtKB:P36888"}
{"id":"7b5ae062-0863-49be-ab73-4a93b687c412","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164852436","predicate":"biolink:affects","object":"NCBIGene:7005","sources":[{"id":"urn:uuid:e2cf532f-444b-4e86-ae88-b99817c463ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12814","original_object":"UniProtKB:Q99594"}
{"id":"ddfd7b74-a57e-4180-9589-3f2b5d492f72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91541","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:18c6bc52-4db8-4a0e-9616-8210f458bad4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:330","original_object":"UniProtKB:P11229"}
{"id":"30170ea4-e204-4027-b088-4824787deecb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16136567","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:9f10b9bd-6980-4a8f-afd2-3ddefc7218ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1458","original_object":"UniProtKB:O43193"}
{"id":"b5a657f1-d630-420d-9281-e9821abc47da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:ff849bce-abe3-4593-9464-7d2b6707f48e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q14643"}
{"id":"65c22862-634a-4a86-b672-4bf57aeeec67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70689167","predicate":"biolink:affects","object":"NCBIGene:164656","sources":[{"id":"urn:uuid:aa94fee6-fdd3-4883-93ca-78e6a043d3ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8624","original_object":"UniProtKB:Q8IU80"}
{"id":"11d24811-62ad-4c41-b74a-29f5e2a7dad4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16158367","predicate":"biolink:affects","object":"NCBIGene:259249","sources":[{"id":"urn:uuid:e6c1c1bb-3aa1-4bd0-ac1f-c97b5ef9aa32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4058","original_object":"UniProtKB:Q96LB2"}
{"id":"919e9e08-831c-418f-939c-09ee3c14d65d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13769","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:9ec99c68-5e66-4f9a-b5e0-b0a0b1362f13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13769","original_object":"UniProtKB:P47871"}
{"id":"47f17fae-9a3c-4633-8d5b-ac2d6c1ca454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9U3GT3353T","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:5f9c28c9-0a2a-4e63-8800-212fb549d968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1624","original_object":"UniProtKB:P41143"}
{"id":"a7606c3b-0c20-4cfc-a25d-c7ddfb04b9fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64159","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:a2e52903-ecff-40f6-93eb-41c7274106c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1426","original_object":"UniProtKB:P41594"}
{"id":"60b3b2ff-ffed-4fc2-ba85-d66843df0420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:14257","sources":[{"id":"urn:uuid:1b23c294-347d-4734-b79f-d0924f04b4bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P35917"}
{"id":"d2e7aa90-ce42-49ba-aa15-ef0f39ead8e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2059","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:a73a157d-7709-4001-941e-40c088d59326","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2059","original_object":"UniProtKB:P30874"}
{"id":"f1429a34-17c5-4061-9f62-9f2d3de1c0b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:772","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:9ad53508-9b1c-422b-af6e-15fd18095d9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:772","original_object":"UniProtKB:P51677"}
{"id":"d5784383-1fdd-4911-a74d-0d74f8e4b32e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:184178","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:b367f65e-093a-4b22-a4a7-91d0ff8c6ec8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1445","original_object":"UniProtKB:O43193"}
{"id":"ef931200-81d2-47b7-9007-99fc4dd33711","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:491774","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:5374124d-b79c-4496-bc93-6974cb18fce4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3500","original_object":"UniProtKB:P51681"}
{"id":"11948c5e-f061-41a6-82d6-1cbff5ebd59e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F3YMY7783P","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:1f705d39-7ee8-4980-a3c8-31f5731fab8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11699","original_object":"UniProtKB:P42338"}
{"id":"c0cbfb54-4319-4812-ae24-7fdd24a7a603","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868459","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:8a758304-ba39-42ee-828b-f4849fd927ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3492","original_object":"UniProtKB:P51677"}
{"id":"c8d68864-2c67-4921-9a75-dd632c02449b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:4308","sources":[{"id":"urn:uuid:ab86696c-e73e-4149-a4a3-a63bb81e6f45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:Q7Z4N2"}
{"id":"8ca1e02b-4a99-406c-8ec0-560d9efdc473","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080554","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:3e1e37e4-d85f-400c-885c-551c6cd504d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4216","original_object":"UniProtKB:Q14957"}
{"id":"cf05025e-f9bf-4a27-9523-254a00cec404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81529","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:b40721b8-fbbb-43bd-a5b2-4402ad6d9b12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1642","original_object":"UniProtKB:P34975"}
{"id":"ad612360-af0a-4240-8e7e-c8fb2b2a4806","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118016229","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:8338dbb3-c454-404c-ae3b-03e8383df3f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11224","original_object":"UniProtKB:Q60614"}
{"id":"1446ecad-3ee4-406e-b852-14f461db2b4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:f59039dd-f04a-4886-94ba-fcdd43ffab6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P28647"}
{"id":"3066f8ae-11d9-42d6-8613-f207d227f775","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146422953","predicate":"biolink:affects","object":"NCBIGene:84649","sources":[{"id":"urn:uuid:e2215502-410f-4b3b-911a-057aedf1ac15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13010","original_object":"UniProtKB:Q96PD7"}
{"id":"74327311-d36d-45e4-b9a5-9e5fc6685cc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494342","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:ba1ba95c-f69d-4657-b7bd-74d09add74c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13401","original_object":"UniProtKB:Q16769"}
{"id":"b8d01df9-978a-41a0-827c-cfe41efe5c19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15854","predicate":"biolink:affects","object":"NCBIGene:259286","sources":[{"id":"urn:uuid:9a416885-0d82-4829-8a77-24ef3fc9e21b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2510","original_object":"UniProtKB:P59535"}
{"id":"d5cd346d-20e1-464c-8da9-8b1e358b5214","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73337","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:d526823c-2e49-4497-8824-32496724e485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1236","original_object":"UniProtKB:Q9Y5N1"}
{"id":"823e4a0e-11d5-458b-9e46-d9633b655fc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:3cebf2ad-51e6-43d7-b9d2-7d96a2f72e19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P35346"}
{"id":"ac0e2953-779f-45cc-9a08-aa446762f578","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:cd713718-8776-4cc3-bf0d-a2aa8a0c2fdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:Q16832"}
{"id":"ee26455d-1edd-4f30-8c3c-32d2646fdff1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47097","predicate":"biolink:affects","object":"NCBIGene:3265","sources":[{"id":"urn:uuid:bd2e2fc4-eb17-4c83-9b31-3ffb75f3274c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8024","original_object":"UniProtKB:P01112"}
{"id":"014baa7d-26cc-4d5d-8192-39e2d55c52a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6JLQ8K35KK","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:59ea0b8d-1f5f-4e63-a37e-0f6362da49b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13307","original_object":"UniProtKB:P15121"}
{"id":"8ef5992b-9d24-4485-9fc9-050cffb879df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FD2SWT2SDI","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:b156a792-ac28-4506-a646-6b80525dd5d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6045","original_object":"UniProtKB:P06493"}
{"id":"fdab079f-234c-4846-90c0-a812eb3cda01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45409","predicate":"biolink:affects","object":"NCBIGene:1577","sources":[{"id":"urn:uuid:68c0ca00-cda6-4fab-a40a-815ca9868ab9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8804","original_object":"UniProtKB:P20815"}
{"id":"efbce761-3541-45b0-8701-a6351ad6de44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85078","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:b9bf67a7-2b58-44b3-b263-80f3acc5ca7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4594","original_object":"UniProtKB:P13866"}
{"id":"a4f06e01-1164-4b65-ba88-c22ce95a5161","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:50801","sources":[{"id":"urn:uuid:d0b2df7b-e17c-4e8c-a919-69e1c34bec4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q9NYG8"}
{"id":"3ed7aa6f-a3c2-423f-b960-17f799284c50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:06DM4KX7JG","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:42d098a4-5d0a-47c1-bbce-d5dc3688e889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11487","original_object":"UniProtKB:P13612"}
{"id":"320743c8-d622-4f66-b018-7ade7a21593b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6E68796C40","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:d647ce11-abbe-474b-986c-941aeb296213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5593","original_object":"UniProtKB:P29275"}
{"id":"25ff78c3-3aa7-4198-a82c-4585dd96f012","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W71J4X250V","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:a27bb4dc-31d3-4058-a70d-f1d14f515b79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8382","original_object":"UniProtKB:O00329"}
{"id":"75511f14-e7fd-4ead-ad66-880bc15fc0cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71952","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:0f102bfa-910d-4a2e-bf0b-166112ad40e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7950","original_object":"UniProtKB:O00329"}
{"id":"be2c6ad6-b86d-4392-b737-c3cccfef908a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4554795","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:e973e9ff-6d09-48f8-893b-bd9abeaeff4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10425","original_object":"UniProtKB:O75116"}
{"id":"bd4f7e7e-34c0-41c3-8848-154f364a96db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11597537","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:d96a42ce-4f25-4846-9c6b-de9c82b06ae0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9836","original_object":"UniProtKB:P45983"}
{"id":"6d72b089-88bb-419e-82ae-c06e6e55579e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:752DF9PPPI","predicate":"biolink:affects","object":"NCBIGene:31","sources":[{"id":"urn:uuid:025ee3e6-391a-4fe2-b745-3979b0b19ef4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12242","original_object":"UniProtKB:Q13085"}
{"id":"a3a649f3-6565-4358-b521-abe2d96b0775","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85403","predicate":"biolink:affects","object":"NCBIGene:84636","sources":[{"id":"urn:uuid:91b1d760-fc51-4677-9818-30af64e96f91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4064","original_object":"UniProtKB:Q9BXC1"}
{"id":"1ea9fa5f-9ded-4e31-bb85-fbeb7ff9cbda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1803","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:3abbc61e-45c7-4db9-a983-19521e932e75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1803","original_object":"UniProtKB:P25961"}
{"id":"a0ae2bf0-ad9e-4c16-8c5a-d731a39a38d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:2e4afdf9-2c90-47e1-b65a-f4f6efa0ea00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P50406"}
{"id":"e2097e79-8bf5-4dd5-b37b-785075da0745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91370","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:487600be-6972-4965-b5bc-8a6f6b15951a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9381","original_object":"UniProtKB:O14965"}
{"id":"5ffc39d4-f7e5-4dbb-85de-9f022c054ece","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:812","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:6a8000c6-9026-4d3c-b8ae-ce39a7fb6440","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:812","original_object":"UniProtKB:P51685"}
{"id":"4e3365ed-b408-4152-9cd9-5588238cd9b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996542","predicate":"biolink:affects","object":"UniProtKB:P21588","sources":[{"id":"urn:uuid:7b8bf92c-0130-4a82-821e-508bbd0c4176","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10706","original_object":"UniProtKB:P21588"}
{"id":"fd94867c-fad2-40ae-a3dd-09a62b6e56f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553174","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:9ab23a88-bc42-46b0-87c7-b6d700982e9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10343","original_object":"UniProtKB:Q9UHD2"}
{"id":"be993477-5615-42f2-83f6-a73575508ac9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:25075","sources":[{"id":"urn:uuid:c0a793af-e134-4c2c-891f-d30cb4cfc04f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P28564"}
{"id":"44fe85c1-ac5c-4b21-8621-3b1b342601ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1284","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:74bc5482-b6ed-4c4e-a795-ca7630f44fb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1284","original_object":"UniProtKB:Q969F8"}
{"id":"8219d20f-fbba-4697-81c4-6094fb68bd9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6114","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:bf058e83-c5ab-4dbc-8d72-4daf7bcbf67f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6114","original_object":"UniProtKB:P47211"}
{"id":"b3e59dc2-863a-44d8-81aa-56663613b5fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50913216","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:ab5bd919-4fd3-4040-8ad0-bf2e9c7ffbf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7856","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"1b3e8734-238f-4890-b3a1-d3f2b3f9a4c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177703","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:97ffd2e0-26c6-4473-be2f-d107c0d5bf57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9635","original_object":"UniProtKB:P43088"}
{"id":"fe791cd6-3b03-4f83-89ed-e650f8e09267","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46898088","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:0f1e0e0e-4079-404e-aadc-fb2b737aa78e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6739","original_object":"UniProtKB:P31423"}
{"id":"4c2b4b07-cca1-4cfe-b607-62d49e7e2a7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81391","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:f64efad7-7f2e-4f28-ad50-1e0273663845","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1267","original_object":"UniProtKB:Q9QYN8"}
{"id":"d427bc45-9568-4da4-b792-e25bcd4689d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:f4fb8916-b736-403a-b2d0-c4e523bc11a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28222"}
{"id":"a43c58f3-aee3-4d81-b642-24bdc7e235ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177705","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:fc6fbc72-7021-41ac-906e-9a9eee9370e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7432","original_object":"UniProtKB:P98170"}
{"id":"2f4219ba-29f6-40e4-a280-d9058a27d018","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:322a907c-42b3-4469-8a23-6931635c3c95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:Q13177"}
{"id":"141a7024-5b37-4bb2-8f6f-048a2e715367","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:931056ad-5566-40b6-91d3-d5c27dc772ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q9Y5S1"}
{"id":"8932e100-6bc9-4b40-907a-ba49c22a45d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167962","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2095b5d7-12e4-4984-9f5e-8a9640a4c2dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:362","original_object":"UniProtKB:P08172"}
{"id":"f2668dee-2232-488f-b0f3-4fa8e6804bc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:d7888d65-d0da-4165-a663-0bf54ec3f0a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:O88854"}
{"id":"f5ca4de7-e52e-4db8-9ea4-7f8c591f290e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72716071","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:455c9ecb-26bf-4a76-a429-9ba3ac821ed7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9268","original_object":"UniProtKB:Q9Y463"}
{"id":"f6a4e559-c0d7-4459-b57a-f2e10c2e23dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK43YC00I7","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:53f0f8b1-155e-432c-8b9e-b51a2b60e896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:183","original_object":"UniProtKB:P41595"}
{"id":"df638276-43d5-4f0c-acb3-9947a3c751d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1999","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:11739fae-f35b-4aff-9163-705e7c48e9fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1999","original_object":"UniProtKB:Q8TDU9"}
{"id":"af775515-4e79-4bf1-938c-3ad4d39c3429","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11710462","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:98566c07-4381-4142-bf01-230b8de78fe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:712","original_object":"UniProtKB:P41180"}
{"id":"4ccf20fd-00b7-441f-a54a-467bd478672c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:939111","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:b24ab5cc-5da1-490d-8a65-ffa1925aa54b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8115","original_object":"UniProtKB:P11309"}
{"id":"4da81295-3e86-4eaa-88fb-23231aef50c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366965","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:b64bf762-effc-4b0b-8695-48a5faa5d912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11732","original_object":"UniProtKB:Q13535"}
{"id":"889bc0fd-10a6-4756-99a6-9cc6b0315a44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L4C1UY2NYH","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:8f9fd4e3-ed67-4c73-acdc-cd011d783c1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9636","original_object":"UniProtKB:P48736"}
{"id":"868fd3f8-8e3c-40ca-8b78-d0473ab73ab8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:b437b8e6-89f4-45c7-b39b-740048b24843","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P43088"}
{"id":"a32c621c-ef02-4d41-99e2-9c933c3477a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5313W10MYT","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:1bcd7e49-cfb9-42cd-8736-9d5be8804b73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1138","original_object":"UniProtKB:P43220"}
{"id":"021cdc49-66ed-48b4-8f02-aca443675a66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91194","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:48de030c-a596-49b2-9f04-3838345b6d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2907","original_object":"UniProtKB:P61793"}
{"id":"fe42e83a-e9c6-492d-b6df-873609c85cab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145704693","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:d482a262-50c4-4acc-a061-151985772b02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10751","original_object":"UniProtKB:Q07869"}
{"id":"0f667719-11c2-47da-8628-ae9e6930edf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:76856","sources":[{"id":"urn:uuid:4e1cdb61-b2ad-44ca-813e-3b7c13db4c86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q80W99"}
{"id":"87e69b3d-2a1f-4cf1-9915-09133e570b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5277GPA358","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:665fa457-af73-49db-bd8d-4fd0412d8e44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9927","original_object":"UniProtKB:Q96GD4"}
{"id":"7ceaeea5-185d-4995-ae2d-9bc8f606350c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47781","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:3a6c4e96-2992-4274-84da-9460f5fb7394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2399","original_object":"UniProtKB:P31645"}
{"id":"01338f09-3deb-454b-84a8-1b681b76d231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311040","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:beb2d0b5-cd82-459d-8c82-77675084f584","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3421","original_object":"UniProtKB:P31424"}
{"id":"a592a41c-c710-44c2-9112-15ffe7020172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:bd31046e-78b3-4186-b942-168125ea17a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P30966"}
{"id":"ea64c9a4-1dc7-4469-86d9-a05c5349bdbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KF50235Q04","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:89323006-a5ba-4478-b022-45bb94876859","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7346","original_object":"UniProtKB:Q9H3N8"}
{"id":"9ff1e3e3-286b-4531-96ac-584568d4e760","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:ec641bd7-ef5c-4baf-a49c-9658fa272964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:Q16288"}
{"id":"072e2af9-0d0e-4130-9b94-256f91fb3c55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182080","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:c5bdf8b3-93ce-464f-b608-7b7d912b7836","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1606","original_object":"UniProtKB:P41145"}
{"id":"36aa25f7-673c-40c3-bd87-ae7bc5ad7865","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FI3KTC550","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:b69ac573-14a2-4ec7-96d6-c4d6860fa5dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4327","original_object":"UniProtKB:P31644"}
{"id":"4d5954d3-1376-405f-bb84-2419e2e1f0ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:c1af39f7-c114-4a56-8e6b-3641c983d174","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P21728"}
{"id":"e139c2b4-cbdb-4d1d-b8e9-299b6be4f415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9908833","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:5c8a2654-47fb-4928-b7a9-e4e34d1a7915","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2671","original_object":"UniProtKB:Q07869"}
{"id":"91ccea2f-04a2-4d32-a0fe-49550f8ea08e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13809","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:00be06e0-5836-403e-9ba7-d46129e0ba27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13809","original_object":"UniProtKB:P21802"}
{"id":"41fb3d07-5e66-42d0-969c-52f4de9988cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MIA4WMP8QN","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:e5432386-6c34-4cd0-a0b0-d81d7ddeb70c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12648","original_object":"UniProtKB:O95180"}
{"id":"2e5cb9e1-a396-4b73-b181-69a1e7132911","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:ef86b0e2-ddaa-4d14-9dc1-7eae17151ea7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P31388"}
{"id":"56bf02f7-0f51-4e2c-8e71-a6742a325f5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9931205","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:4961de7e-2cdb-4f73-9811-75678d93e9cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1423","original_object":"UniProtKB:P41594"}
{"id":"8abc2af8-a904-49cc-bcba-8f3a9fa4fbc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10400683","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:24d28767-21f9-490d-830b-63e54766f161","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6448","original_object":"UniProtKB:P31424"}
{"id":"b0cc8227-828c-448b-9ba6-50d77b127ae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311382","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:86f9e0d9-59ff-4ac7-978d-3f08c829009c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8183","original_object":"UniProtKB:P09619"}
{"id":"8eebd076-1cfd-4ca0-8de3-7d9b42fb9cb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177451","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:bfd5486b-dc9e-4a6e-9dc5-597517eca864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6484","original_object":"UniProtKB:O14842"}
{"id":"3e2dc394-045e-436f-8d35-0c62d31d0737","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4702","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:78d50a92-b17a-420d-ae52-396fb5a50c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6810","original_object":"UniProtKB:O43570"}
{"id":"10df8add-22dc-475c-a0b3-375a7aeb56bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817422","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:a6ad57fc-e6c1-44f7-a121-0d21e6f756ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1549","original_object":"UniProtKB:P21555"}
{"id":"998dd92d-c3a2-4638-b8c8-6fd314a76936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ANGHS285FG","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:ece9770c-2a10-4c58-a2ba-b11076e85720","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9393","original_object":"UniProtKB:Q5S007"}
{"id":"3236cca1-f7c0-466b-8110-bf539a55cd98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25207521","predicate":"biolink:affects","object":"NCBIGene:53944","sources":[{"id":"urn:uuid:569023c5-da4b-4239-b746-ae242183c311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8163","original_object":"UniProtKB:Q9HCP0"}
{"id":"b1e9eca7-8931-42ff-9110-ec22a19ce922","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57377246","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:480ed229-6bc8-4b98-9593-7df400bc8500","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8368","original_object":"UniProtKB:P14416"}
{"id":"3f25c1c4-3b4b-486a-87b7-9d205820b1fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92339","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:1141e028-b005-407e-8169-bbeec29e71d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10348","original_object":"UniProtKB:P34972"}
{"id":"9220db29-512f-4c95-89fc-d24b0eca5cc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422745","predicate":"biolink:affects","object":"NCBIGene:57787","sources":[{"id":"urn:uuid:46908594-5a27-436b-a4d5-9986d8b07b0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12936","original_object":"UniProtKB:Q96L34"}
{"id":"2cc14a23-1e34-45d0-8362-ead5344bfa43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107660","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:a05f14c3-ac8c-43ba-a6e8-40c138e08083","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2361","original_object":"UniProtKB:Q14957"}
{"id":"dfd6c6c6-8bfd-4f0f-87de-e50faa6fae41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2060518","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:cda0ae69-b470-4336-a294-c4b78dd2009d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11309","original_object":"UniProtKB:P42262"}
{"id":"96d8f7e9-2f1c-44d4-8097-4c799be493ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131351","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:39495c8f-01f6-49cf-9749-211657634a5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:384","original_object":"UniProtKB:Q60614"}
{"id":"16015fc5-afc2-4a0e-85a5-0567fcac643d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:869226db-ba25-400f-9578-f547c6bfddef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P08909"}
{"id":"d89b626c-31e7-42b0-bdfc-c27fa425ff6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:80e3c762-6c17-4f8c-99d4-7ce4cde3e357","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2416","original_object":"UniProtKB:P22460"}
{"id":"fbe4a05e-84a6-40d8-9d94-6fb30022fa0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:3987dcb6-f0a0-47df-9539-ec0c15f8a25f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P30939"}
{"id":"fd165924-6ecc-4342-916d-096eacffcd5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433319","predicate":"biolink:affects","object":"NCBIGene:51776","sources":[{"id":"urn:uuid:e404c516-4bee-4458-ad00-39cccb8843f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12845","original_object":"UniProtKB:Q9NYL2"}
{"id":"e31f557f-4fc7-4d43-98fd-9fd7210a06fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:679906","sources":[{"id":"urn:uuid:67348ff6-cba5-4f74-89bb-cb88a325bdfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:Q925B3"}
{"id":"962f9cf3-64e1-4d01-9c3a-9fbc200b38e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:f66f743d-4587-4801-9e0a-dc96d4360c02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P11362"}
{"id":"2ed11e0c-5a52-4c5a-81aa-e088c49f928b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16828","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:e2c8b805-b8d6-4d6d-8099-1f5a3b39a8c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:717","original_object":"UniProtKB:P41180"}
{"id":"9291f233-ec02-4cb7-afc2-a4ba69ad5484","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197230","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:877051e6-b853-4637-967c-f789fdce3c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1968","original_object":"UniProtKB:P43119"}
{"id":"67ec5d65-5b7d-43f3-bff5-f15ec42e9205","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231405","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:ba15bc9e-2ed4-46d6-a357-977ea8ac1472","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9160","original_object":"UniProtKB:P35372"}
{"id":"93a6ad7a-c98d-48ea-bd12-bfeb33afdb46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36259","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:b1996eab-1531-44c1-b30a-a38700fce1a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4548","original_object":"UniProtKB:Q9NYW7"}
{"id":"3aa04d4a-0671-4aeb-8591-71e12d0960c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49868","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:82c5a06e-4f39-4561-8d71-49276dc7e552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5666","original_object":"UniProtKB:P53350"}
{"id":"a99a7f71-9911-46dc-9deb-e93fc823cdbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:23aa1597-ca11-4216-99bc-a9affc296f8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P34969"}
{"id":"418fe0ee-3855-453b-9564-49b74cf3bdd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91706","predicate":"biolink:affects","object":"NCBIGene:83535","sources":[{"id":"urn:uuid:308f2098-1149-4dcf-9124-1a9237eab2f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2412","original_object":"UniProtKB:P70673"}
{"id":"2530f134-4567-4b72-9aef-93b2f0144b80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44473434","predicate":"biolink:affects","object":"NCBIGene:3636","sources":[{"id":"urn:uuid:8a22919e-0f9b-4a5f-824f-a7968cdc6b5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8878","original_object":"UniProtKB:O15357"}
{"id":"bc34ff27-956c-427c-b5b6-a860e1bf5a12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801483","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:41f23509-17af-4d88-976d-897c8a084684","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10547","original_object":"UniProtKB:P50613"}
{"id":"3b139cfc-82ce-43b3-bb06-e7430772dd40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:0797bdde-9828-4819-8147-28fab55795d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q9UQL6"}
{"id":"b359d6e5-7764-4b93-ab7e-72862765d50d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75037","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:b33540c2-9a4c-4a1c-889a-015e317a8538","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7353","original_object":"UniProtKB:P07550"}
{"id":"716024c1-80fb-4b54-8f19-bbfdb4e8757b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:786ece3e-336b-424d-bd3b-70eb370be23b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P18089"}
{"id":"84b464a7-da67-4c1c-b8fb-133ba3e3852d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3566","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:e8e3fecb-c8af-488d-a408-c332cd1f1adb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3566","original_object":"UniProtKB:P32239"}
{"id":"910a410b-ce11-42dd-afe4-154d6a672a0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177647","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:fede1d4e-31be-4245-a955-4477baf1f38f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5604","original_object":"UniProtKB:P25099"}
{"id":"2a725672-cfa5-4910-a4c5-48b03ae1a9b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60168729","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:17ce845e-d182-43f3-b22c-ca34a4f330c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12566","original_object":"UniProtKB:Q99571"}
{"id":"91423c59-5ff0-4e08-b1ac-4633375fe9a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:818","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:732d96c2-7dd4-4a99-b4ae-5c94dfe1bbc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:818","original_object":"UniProtKB:P25024"}
{"id":"8ea6aaf3-d145-4543-bb24-77c518ab1edf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5442665","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:bbc11560-1372-4ce9-9b96-2ec7afbe72fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8518","original_object":"UniProtKB:Q8TCW9"}
{"id":"3b85db8f-2b51-4918-bfa5-20d65056cf44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072548","predicate":"biolink:affects","object":"NCBIGene:51111","sources":[{"id":"urn:uuid:d64ec7ee-04dd-4d7e-8baf-b2321a147981","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8949","original_object":"UniProtKB:Q4FZB7"}
{"id":"c65837f3-bba7-4365-8040-7e8805c2bbe3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7747","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:9e4f995a-198b-459c-9a9f-d06e35aa7c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11027","original_object":"UniProtKB:Q9NYW2"}
{"id":"102dbf3d-18d6-44c1-9bf0-8d5dabb12aba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S3OPE9IA3Q","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:6bd9107f-4ca2-46ea-8b7c-74ab971f0a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9788","original_object":"UniProtKB:P22607"}
{"id":"326a9f0c-8f25-4edf-88ca-59cfe70619f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:6197","sources":[{"id":"urn:uuid:d95189ce-3916-4fee-a74a-e156a6d5f913","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P51812"}
{"id":"f04c8515-97ff-4062-8155-f6744ac1a60b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48669","predicate":"biolink:affects","object":"NCBIGene:5340","sources":[{"id":"urn:uuid:f2ecb1cb-8f39-4cec-a96c-9d9fe975ac99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6573","original_object":"UniProtKB:P00747"}
{"id":"bbb4c618-753c-4b6f-9a48-c9f37c5eb0ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2003","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:a6ce7eb3-0f13-4176-a05d-fe7b2c1e27dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2003","original_object":"UniProtKB:P30935"}
{"id":"40532e47-2f2b-452e-b819-d15d49b6d988","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44270471","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:ba1c2988-c580-4b39-a1b0-f4dbbb28c07e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6722","original_object":"UniProtKB:P48449"}
{"id":"94f69b6c-c250-441e-81f4-ab30fb8dd96b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3897","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:461d86b8-320c-48f5-b38e-783979ccfa01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3897","original_object":"UniProtKB:P47211"}
{"id":"c104998d-2703-4e4d-8334-f9354edde205","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164517202","predicate":"biolink:affects","object":"NCBIGene:124976","sources":[{"id":"urn:uuid:641342ea-ddba-4cbe-b757-d1451e53d862","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12695","original_object":"UniProtKB:Q8IVW8"}
{"id":"e62d4223-e312-4018-8a7c-5086dddd787f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53394037","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:62e0f7f7-1f53-4e6e-a3ee-3c400c9a6c43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8305","original_object":"UniProtKB:Q13547"}
{"id":"d3f1af1d-4797-4055-9e1f-1a1dc57fc7e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65349","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:8b755bed-8d24-4a66-9ea3-968f50701108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7445","original_object":"UniProtKB:P25962"}
{"id":"ad445a51-9f00-4381-af66-c7aa518fa297","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R2N8IH71HC","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:80a8835f-e7f2-4824-8187-7af19bb8fa68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3334","original_object":"UniProtKB:Q9Y271"}
{"id":"b19b4cbc-e2f4-431b-900e-ae3f4572ae9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W6I5QDT7QI","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:096e9fb1-182a-4fcc-8163-39cf4de2bccf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9322","original_object":"UniProtKB:Q13464"}
{"id":"69bd6413-47e2-43ea-973d-328a6ed5c249","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139533572","predicate":"biolink:affects","object":"NCBIGene:7075","sources":[{"id":"urn:uuid:ca8e06ae-0819-446f-8414-98a5be047e1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12249","original_object":"UniProtKB:P35590"}
{"id":"81f71e1c-7a0d-43a1-ab06-3696c041fb5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:37397da2-8f61-498c-b1f5-6bc0d66c2268","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2346","original_object":"UniProtKB:O94759"}
{"id":"bf3d2c17-0e37-46c0-bc60-f04883b7560a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6690","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:14d04122-3186-41a6-acbe-eb1930d4fe6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2402","original_object":"UniProtKB:P23975"}
{"id":"3d0ca8b7-70ae-49c3-a8fe-e797d7acb784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59234231","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:b7e60d09-5c53-4226-b5eb-9316090ccd33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6330","original_object":"UniProtKB:P31421"}
{"id":"9fe44f99-63a5-41b9-a7f2-f5e5f84df68f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755027","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:aee1d14a-fa2b-4821-96e8-b0a37f12328e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2492","original_object":"UniProtKB:O35433"}
{"id":"70aacc17-ed60-4be5-ad02-27b3adbb1540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164607233","predicate":"biolink:affects","object":"NCBIGene:2160","sources":[{"id":"urn:uuid:16c0dcc9-6767-4993-bbf2-b8d1899017e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12133","original_object":"UniProtKB:P03951"}
{"id":"b0a3dd9a-6f88-4a25-957d-6f58bf31ec3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2K59L7G59M","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:41efe4a6-7713-4974-a6d9-c8c2d584609b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9728","original_object":"UniProtKB:O00329"}
{"id":"512e88f2-a4a8-4271-9a54-7e9359977479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:f849b2a6-2d27-4e1c-8a2b-7a2831e43358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P16234"}
{"id":"d057f501-a8c6-4d13-9066-843706cb4b5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080554","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:5fc82c11-4d0f-489c-897b-c7552a972608","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4216","original_object":"UniProtKB:Q13224"}
{"id":"4c3c1a66-2f66-406d-9d51-40b50cff590a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65349","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:f99c96fd-e7e8-40b1-b9a0-f49f2b17fa74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7445","original_object":"UniProtKB:P08588"}
{"id":"69ee2a4c-dd77-430e-98dc-714351df55c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DY6W3NQA36","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:5ff1db1d-51b1-44d7-b0dd-87dc98c54edb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13188","original_object":"UniProtKB:Q9Y233"}
{"id":"2cfe046e-4cfc-473d-92af-5cfdfc51aed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8B97A88D35","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:151b9602-1f0d-4dc4-b4fd-167706f90c80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8915","original_object":"UniProtKB:P42336"}
{"id":"e418088e-b983-4cee-a359-2cfea2875550","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136046","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:f76579f5-6408-4212-8235-56b33e563c34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10423","original_object":"UniProtKB:Q13464"}
{"id":"5b1b83ea-e86d-46bf-ba75-ea91e990f2e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QR88H79VX","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:f99f8c5a-7548-45bb-9230-1a256e4b8012","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9600","original_object":"UniProtKB:P43405"}
{"id":"f5999937-b719-4383-8015-6f1528f4938d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71200","predicate":"biolink:affects","object":"NCBIGene:5585","sources":[{"id":"urn:uuid:9571b44a-2e67-4bf9-a5aa-5b1d912d27b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5677","original_object":"UniProtKB:Q16512"}
{"id":"b04eb703-04ea-4b04-9d86-52ae066ea784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71364","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:3f8f8749-c1ef-43d1-9625-ccd2d6e2cfed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:667","original_object":"UniProtKB:P97583"}
{"id":"51f9ce87-7c78-497b-825d-a056ea30258a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6935","predicate":"biolink:affects","object":"NCBIGene:2548","sources":[{"id":"urn:uuid:2b7487c6-4640-4361-b920-bc63ad22a2fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4842","original_object":"UniProtKB:P10253"}
{"id":"3f715268-3f09-4cd8-a021-d7437c7115dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8228","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:5dd6b6ad-df70-43bb-969a-dd839e02527e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2694","original_object":"UniProtKB:P37231"}
{"id":"d9eb83da-73a6-4b16-b866-1f91f010d19f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:65180","sources":[{"id":"urn:uuid:073b198e-b999-4ab6-9e11-4bb829070603","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q63881"}
{"id":"94577e0b-52b6-4c14-8fb3-099646fcd3a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:d923a603-dd4a-4c70-b4a8-91b068509c71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P35368"}
{"id":"be4b36b5-c493-4dc8-aafa-993f72864669","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60166172","predicate":"biolink:affects","object":"NCBIGene:227289","sources":[{"id":"urn:uuid:1750c438-8592-4258-b65b-0a8536caef83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9078","original_object":"UniProtKB:Q80SS6"}
{"id":"6b8969e0-1910-4dfb-a9db-7dcce7b9c7a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136040","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:cae9776f-dee4-48ed-acf3-157b10b63a79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7435","original_object":"UniProtKB:P31645"}
{"id":"104a88ac-49e1-458f-9282-994c07cfda15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121293916","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:ddac03dd-9945-44e3-8f19-26f1954e677f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12734","original_object":"UniProtKB:Q06187"}
{"id":"d474a90d-6bcc-4cec-850c-5f8d1690051c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1585","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:5da04703-81b4-45c6-a9b2-9750fe11a21d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1585","original_object":"UniProtKB:P70310"}
{"id":"c94cdd06-6ee3-4331-9f4a-3b5ebeef0047","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9449","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:6a6b0c77-067b-4026-8bbd-384679cec50b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:560","original_object":"UniProtKB:P07550"}
{"id":"2959a15c-bc2d-4543-ae75-7feaa4a78fb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135899","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:a244cc45-2f37-4151-9eaa-08590309aa1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2213","original_object":"UniProtKB:P30518"}
{"id":"54011f70-8a42-44c4-aba7-f9d6f1932547","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311291","predicate":"biolink:affects","object":"NCBIGene:7201","sources":[{"id":"urn:uuid:7fac0193-b909-47d2-ba3a-204436a34243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2137","original_object":"UniProtKB:P34981"}
{"id":"86f42ec0-ec01-421e-93f0-efd8e986a079","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:bbac1b23-036c-4110-ba26-033e80142373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P49336"}
{"id":"92b6f5a1-7493-4881-bfd9-2877b323afe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755043","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:d972e7cc-4e59-4dfe-80b9-dc1a048065d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3338","original_object":"UniProtKB:P47900"}
{"id":"df9a9e5b-2f0d-4274-a8aa-26312860db39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340686","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:c27832e1-dcd0-4bc6-b69a-1ad0ee233202","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8058","original_object":"UniProtKB:P45984"}
{"id":"96aae3c0-2241-486d-9751-25cc397e2890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:6788","sources":[{"id":"urn:uuid:b0c9907a-80a9-4e67-8d00-a779c9a70196","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:Q13188"}
{"id":"a009934b-ae5f-48af-bb54-3b71b8a1b952","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93641","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:caa495bb-bf21-4b04-b07a-cc6627d5ef56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5924","original_object":"UniProtKB:Q00535"}
{"id":"4cb207d2-ba00-4066-89d8-95afea4047e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156624506","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:96d6f3ef-d4b2-461e-b583-48ffc8cece3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6359","original_object":"UniProtKB:Q923J1"}
{"id":"11f65440-2bcb-4343-8b4e-613b8be3c0d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46908026","predicate":"biolink:affects","object":"NCBIGene:9748","sources":[{"id":"urn:uuid:9cd054f3-6b46-4d48-b805-79015ad0a8d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8249","original_object":"UniProtKB:Q9H2G2"}
{"id":"e4d9c191-be30-4fc7-b9ba-8b8106c74338","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123884","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:8c2659e7-fce4-4b6c-afb6-93be398e9667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:641","original_object":"UniProtKB:P97583"}
{"id":"b11e811c-7516-4319-9f15-5ddfb8fffe3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6717","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:c1661f89-3c83-4d04-8215-b59d8a926b55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2593","original_object":"UniProtKB:Q12791"}
{"id":"d2a0de9a-6724-4f7e-85a9-f2eb0b1222f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9Q3ZU9CRL","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:d8506ded-aa9d-44ab-b55e-245062d2d009","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5931","original_object":"UniProtKB:O14965"}
{"id":"95d8307d-4c97-4e29-b9ab-d0e8a8c9f3f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393295","predicate":"biolink:affects","object":"NCBIGene:22848","sources":[{"id":"urn:uuid:87f0e5c9-b25a-491c-8289-8cf8e80c35e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10403","original_object":"UniProtKB:Q2M2I8"}
{"id":"29c4fb56-b542-490d-a064-5e21e03a4ef0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67116280","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:0f612149-3848-45ed-af9f-906a84fda747","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9308","original_object":"UniProtKB:P56718"}
{"id":"0582738b-5008-4fed-9246-f5df200201ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5720","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:3444d4c5-446e-4761-814e-782f9abc08ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:324","original_object":"UniProtKB:P08173"}
{"id":"51e8d370-47e1-419d-aa58-ead1f426b9db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:918","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:09d25c48-0a1e-4aa1-90c0-46f56c9a9570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:918","original_object":"UniProtKB:P47866"}
{"id":"0353392e-5714-468f-91ef-62cb203abfb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2896","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:ac2842f1-3420-4bca-aa7b-2694ec78f283","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2603","original_object":"UniProtKB:O95259"}
{"id":"00e150bd-9d4c-4b9a-8cf3-ad06e92351e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T4W68CAT3P","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:5fdacb31-13d8-4e99-8c32-c85f3ab16aab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5690","original_object":"UniProtKB:P35968"}
{"id":"d941ba45-2908-425a-8c8c-3bd5afb498f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:770140J08A","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:2655cac5-1e62-4bb8-8cf8-3836dbee45ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11153","original_object":"UniProtKB:P29275"}
{"id":"6c9600a9-1f9c-491d-83a6-538481374540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50997674","predicate":"biolink:affects","object":"UniProtKB:Q59H18","sources":[{"id":"urn:uuid:54171da4-87d6-4b35-826e-b664e3aa8c2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11806","original_object":"UniProtKB:Q59H18"}
{"id":"57caddfc-3fa3-46a2-a8a5-5aaaa1efd29c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9TG5O4V25H","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:e015620c-4b61-4f04-b28e-b5d5c2cf0c42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9790","original_object":"UniProtKB:Q9P1W9"}
{"id":"337ca3bf-b454-460f-9ced-54770f919ea1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:97B5KCW80W","predicate":"biolink:affects","object":"NCBIGene:6403","sources":[{"id":"urn:uuid:8d19b075-45e6-4e4a-85be-167be5671939","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9049","original_object":"UniProtKB:P16109"}
{"id":"461003ae-3ff3-440a-ab80-c5a92c273701","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:e650af07-31a2-4d49-bba6-f0a970be1bc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P50406"}
{"id":"3521112e-c3fa-4ced-833c-9d13c04bb971","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:77461257","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:1735c770-0b4a-4cc5-9da0-25239e5bcfa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11316","original_object":"UniProtKB:Q9HBW0"}
{"id":"d9706794-c192-4f13-aef3-ab31497e2605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131409","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:7b99aff5-4a35-4e1f-88aa-e17c82b2e232","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6086","original_object":"UniProtKB:O08726"}
{"id":"6679d693-3f9c-49b7-96fd-a90a33c00d7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21202952","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:ec4df75b-ebf1-492b-afce-c6eb799b85fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4208","original_object":"UniProtKB:Q12879"}
{"id":"c866d2eb-edc6-4d02-bc02-34e735470fe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c56047cf-4ec1-47f2-844d-5c1a2497cb87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P28335"}
{"id":"d15de6e9-6453-4895-8fff-e0d5fe161cf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XM930M133O","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:c0737184-a186-4b18-8f68-c4fc49008dd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5157","original_object":"UniProtKB:P24557"}
{"id":"3322e043-e385-4fcc-878d-43120a9bbe14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156499897","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:d4cca7a4-0f86-4a91-9449-929efad55be4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13892","original_object":"UniProtKB:Q9NQS5"}
{"id":"9dc1d464-b58f-4035-adcd-e2f44004ec0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9164","predicate":"biolink:affects","object":"NCBIGene:3000","sources":[{"id":"urn:uuid:867380d9-fa5a-4318-bcdf-e6b63339e009","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9164","original_object":"UniProtKB:Q02846"}
{"id":"6c6f052d-f786-4199-8b8c-693a1ec92f7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LQ52UF48A","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:67397465-5edc-49d5-abf1-f78557aa064e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5945","original_object":"UniProtKB:P50750"}
{"id":"213d4a57-d6d7-41f5-ba68-e365e6127dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:349c1ca4-22fb-4eef-8e46-4a786557dc2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:O00444"}
{"id":"7ce86755-6dac-4115-8a0a-93ad3c9dc8d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:1325f342-9411-4e08-83d6-937a7f8804e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1399","original_object":"UniProtKB:O15303"}
{"id":"48b8d523-5d24-47fc-9802-4c5cda57604f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164886635","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:7b9aea8c-f77c-4d13-8185-d46c14e895c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12062","original_object":"UniProtKB:P42336"}
{"id":"76ca3b1f-c821-4951-aca4-27a34fccca0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135123","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:296b18c7-1d93-46e8-9671-b14ff95b1be7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:550","original_object":"UniProtKB:P08588"}
{"id":"1851c268-15a2-4cc8-bfb6-8a20913a96cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68764898","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:86a9af64-e12e-4043-9f03-431f3a0e2666","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9430","original_object":"UniProtKB:P51681"}
{"id":"8a06240c-29f0-4d9b-a86f-c32657a1d9d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131152","predicate":"biolink:affects","object":"NCBIGene:8242","sources":[{"id":"urn:uuid:0e1b056c-1354-48eb-af6b-714161804680","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7027","original_object":"UniProtKB:P41229"}
{"id":"8c0ed215-713b-4692-800a-223b82851273","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168665407","predicate":"biolink:affects","object":"NCBIGene:5593","sources":[{"id":"urn:uuid:120f4f26-cbb4-4ef4-b1b2-e230a35262ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13089","original_object":"UniProtKB:Q13237"}
{"id":"152b1f63-3578-43e6-96fb-5dda666ffdba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49537","predicate":"biolink:affects","object":"NCBIGene:72512","sources":[{"id":"urn:uuid:18090f47-1ae4-47c0-91b5-118f5cfd2c4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13137","original_object":"UniProtKB:Q3TBT3"}
{"id":"ced71ad5-8254-436a-b598-daf88c987d20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:627","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:bce8fe4d-cd18-4874-a49e-26b3bc37c90d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:627","original_object":"UniProtKB:P30550"}
{"id":"ab8dd8d1-6ab5-484e-b4b8-262d9c550bde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:2287ed24-a469-4eb3-bb73-49c15a3c7858","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P30542"}
{"id":"a8eb8f35-2b93-4fdf-8809-c2313179258d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9398","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:c476f2ce-584f-416f-a0d7-20e0c0b9aae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:488","original_object":"UniProtKB:P35368"}
{"id":"58481e34-e35c-427f-a69d-cd3fc26ea83d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2033","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:4bd700a1-88b3-4f05-bdbe-18572bdbc07a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2033","original_object":"UniProtKB:P30680"}
{"id":"e81dd488-02a3-40df-950a-e3cd22085916","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13796","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:b86916c4-7275-47d2-8cea-d9dec349ba35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13796","original_object":"UniProtKB:Q15116"}
{"id":"2de669e6-9ec4-4042-a939-cc56cb792d80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:912","predicate":"biolink:affects","object":"NCBIGene:4158","sources":[{"id":"urn:uuid:ea55a85e-6e1a-46b1-99de-b885232f5663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:912","original_object":"UniProtKB:Q01718"}
{"id":"e2ef7394-2abb-4d15-9387-c25536aae8c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13288","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:172261d3-8f66-49de-8f6a-c02208495046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13288","original_object":"UniProtKB:Q96KQ7"}
{"id":"bf2ac118-cc75-48c7-8afb-3de2fab51cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229764","predicate":"biolink:affects","object":"NCBIGene:7514","sources":[{"id":"urn:uuid:34dd646c-31b1-45b4-a8e5-cc182e488f18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10036","original_object":"UniProtKB:O14980"}
{"id":"99083600-ef60-41dd-b228-8f7ccb1a0969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9519","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:ccb627ef-0834-4de9-a65c-6b55aa1dac33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13146","original_object":"UniProtKB:P35372"}
{"id":"7a403a32-09f7-4ab1-b9e7-1cbcd4a56dbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137113","predicate":"biolink:affects","object":"NCBIGene:114642","sources":[{"id":"urn:uuid:39c916e4-db5c-4799-b91b-cf6d04d52600","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7511","original_object":"UniProtKB:Q91Y44"}
{"id":"0d4cb1df-5bfa-492a-8424-af061118eff2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6112","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:b4fefaad-9081-49f9-aa05-b28f4ced0507","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6112","original_object":"UniProtKB:P47211"}
{"id":"0fb61a42-af1a-42ee-8b7f-ccfb53454df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:c37205ce-4bef-45dd-aa5a-5e79e878267a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:O94759"}
{"id":"0bbf2f8d-d4df-40c9-aea6-0e7b041b29ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134709","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:33761024-ed03-4d5c-8e42-62d2ce4bda35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8924","original_object":"UniProtKB:Q9H3N8"}
{"id":"2dd96145-fe5e-4656-ab23-bb16c3a452b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164886635","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:792fe9c0-e127-4a41-91ee-214da9b0a6f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12062","original_object":"UniProtKB:O00329"}
{"id":"13dc33b2-eb36-47ec-b012-11ab7912fa36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7478","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:542f1ce6-5d31-49c0-918c-d693aa5e9999","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:45","original_object":"UniProtKB:P28221"}
{"id":"9c70ed0a-cdcb-4c56-848b-21ca08c1392b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:f6643828-b677-4a6a-a006-ca8be17fc62f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P08908"}
{"id":"161b3e4b-b0f8-40cc-a3db-224e107264d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3804","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:f77bc715-5550-4a69-8c70-fab0c7ca8184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3804","original_object":"UniProtKB:P41968"}
{"id":"e3e55663-ecf1-4a58-90c4-e823a101060a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95061","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:aa02db8d-0d4f-4c9f-8474-252d7d3b91c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8784","original_object":"UniProtKB:P11309"}
{"id":"12a18eec-a981-4f5e-9f43-4f3d68f4c55c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135694","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:695e8568-ec61-4672-8a54-f76d1ac83c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2197","original_object":"UniProtKB:Q00788"}
{"id":"86e9ebcc-6291-4480-b40a-c2bd4224d6bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64156","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:048841fe-76a5-4227-9958-e8ac29d47929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1250","original_object":"UniProtKB:Q9QYN8"}
{"id":"fc760418-5f8a-48be-b11c-81db7fcbfd4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2430","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:a879e84a-1475-413e-b10f-c33ca40baad4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2617","original_object":"UniProtKB:Q14524"}
{"id":"a6ed48a8-622e-4594-9731-2f3f8c894bcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611893","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:4130ad22-3dd4-455e-ada4-05ce70d78c0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9995","original_object":"UniProtKB:Q08881"}
{"id":"ecbb618a-5ad0-4c2f-bbc5-2485147634cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146018968","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:cb1ad4b1-4957-4ac7-8f0f-7b2db700393f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12525","original_object":"UniProtKB:Q9Y210"}
{"id":"213a1be9-31e9-46f8-8fcb-a86cab47174d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3210","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:8c608481-43a4-42bc-8317-db6971189495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:144","original_object":"UniProtKB:P28221"}
{"id":"dda6bb5a-3b6d-47dd-a0cd-f7abcb167811","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:263dd1ad-1d4d-4316-b7b9-d84b40db9902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:P36888"}
{"id":"ed207d1a-bad0-44f5-a7de-de671ba1f60a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1008","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:f3ddf484-9497-4a69-9107-472c4409f2c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1008","original_object":"UniProtKB:P21451"}
{"id":"214c70a8-1ce4-4caf-b63c-76ca7027d3fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71622431","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:bde97db9-cc02-420e-9770-b1ef59ef7e78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11878","original_object":"UniProtKB:P23458"}
{"id":"91ee73f0-1d35-401c-9967-950eea8eb787","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:11540","sources":[{"id":"urn:uuid:8742fd78-ff40-4a3c-a0a5-1ae4b4ac04d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:Q60613"}
{"id":"b233ce49-0ea6-4d12-8759-bedb481ea8f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"UniProtKB:P52191","sources":[{"id":"urn:uuid:238587af-08bd-4a35-8763-1a82577a4675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P52191"}
{"id":"fd520c9b-0f99-45bb-802c-89466773c931","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70255","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:2e91ebbb-a909-44de-bb9c-938f02cbda38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12462","original_object":"UniProtKB:P59534"}
{"id":"aa16c681-59a0-46a6-8511-a816072b46e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:d1df8633-0d0e-43c2-a94f-5193de88674b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:P08581"}
{"id":"c952c8cc-11dc-4155-89d2-3589ffa1173e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:d6d33678-a99c-40f2-9ea6-f390b547fc6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P35462"}
{"id":"34b6a90b-fcca-4107-9b1e-e7ce6d7ad0df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:7616033","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:932532d8-a5cb-4731-9cf6-f50feb031176","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10122","original_object":"UniProtKB:Q86WV6"}
{"id":"51cf5b05-61b2-43f3-8507-02236d7841ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:a32ac143-7d75-47a8-9f90-709c5be98129","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P09619"}
{"id":"a7eb416f-4f1d-46f7-8b32-678d56ed5b7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1865","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:9b82c257-4703-449c-81b3-b41921db93f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1865","original_object":"UniProtKB:Q8TCW9"}
{"id":"fb918317-ff2a-4fef-9fc1-f7687e15e4cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:107757","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:c95ef862-91e9-4ee3-87d8-b31fb2f644ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1852","original_object":"UniProtKB:P25105"}
{"id":"b107bff7-50ec-42b8-834d-43c5bdc3606d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5PC250KSSH","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:151dab0d-0857-4409-90a4-bea385ae4c7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1737","original_object":"UniProtKB:P41231"}
{"id":"31092621-91dc-44e5-acc9-ba61119b1a41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172333","predicate":"biolink:affects","object":"NCBIGene:66002","sources":[{"id":"urn:uuid:010cb3e7-dd0d-4eff-9c46-9159169c2b66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11373","original_object":"UniProtKB:Q9HCS2"}
{"id":"6e4cb211-203b-44ed-8250-b71273fac5aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92949","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:62c4c182-c565-4387-a04d-ea22a6425535","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6009","original_object":"UniProtKB:P49137"}
{"id":"002122f3-38ea-4172-8477-6edab514fd2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3772","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:634b8aa3-8c33-4f9d-8485-feafd9c4a8a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3772","original_object":"UniProtKB:P30680"}
{"id":"41e61f9d-552b-4724-bb47-5d693083e7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DFS3SIU1ME","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:b3033e26-1dfa-4a2d-89ea-501969524ac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1374","original_object":"UniProtKB:Q13255"}
{"id":"2c1dc723-0f3e-4406-a499-12d5bbb1a6dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817505","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:277b8ace-48ca-469a-8e58-12f8eb89ca76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8971","original_object":"UniProtKB:P48546"}
{"id":"89fe5346-189a-4a8c-848a-fe5c558a57ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92714","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:805fa6b5-4caf-486d-9a19-ca54836fe7ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3288","original_object":"UniProtKB:P25099"}
{"id":"8e15296e-f63f-4648-a473-39c7ea650662","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311058","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:d58892dd-488a-4b72-ad53-42c2a8d6e907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1674","original_object":"UniProtKB:P35372"}
{"id":"0c720da5-7df2-499d-b96e-47ea4571bb8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92912","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:aa001bac-eddb-4d66-9006-017c9e18e7e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2115","original_object":"UniProtKB:P21452"}
{"id":"dd8f2c93-eeff-4f8d-82aa-7fbd9af2599d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17148","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:8cfb24d0-b5ce-4541-9e68-2f58e374b62c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2388","original_object":"UniProtKB:P35561"}
{"id":"7b7ae03e-df07-42e9-a7fe-3fe5c7314530","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6479","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:f47e3e77-6cea-42f9-b2c9-b067ce4c7eac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6479","original_object":"UniProtKB:Q9HC97"}
{"id":"e887e68e-3a5f-45cc-8653-f1888597d345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:38515f86-f38c-4d11-be9d-e368de64c8f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P16234"}
{"id":"4a4efd30-20f8-41d6-8fd0-9a46eb260b28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51035721","predicate":"biolink:affects","object":"NCBIGene:79400","sources":[{"id":"urn:uuid:4f301d7a-f0d4-4170-a6d7-37fb1e4cbf36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9931","original_object":"UniProtKB:Q96PH1"}
{"id":"57c1cc7a-9fef-440f-9246-7e211d5b6458","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755126","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:29cd9016-14b9-4f43-88b6-203f8e916c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5515","original_object":"UniProtKB:Q9BXA5"}
{"id":"89a85d34-5d05-41dc-8718-6559de1382db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:31YO63LBSN","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:7b2c2eeb-f7a7-421b-92eb-f0ca925d5655","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7335","original_object":"UniProtKB:Q15116"}
{"id":"54472406-987b-4067-8135-4232ba3f0b20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5296","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:7960ad78-43a9-4546-a9ad-b8bb96d85bcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3439","original_object":"UniProtKB:Q9Y6L6"}
{"id":"378b737d-9920-4362-99df-1a047000f966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73458","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:10a7c9a8-3bbc-4732-8509-d0cdf851f9aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8976","original_object":"UniProtKB:P35354"}
{"id":"be563e29-6db0-42f1-8808-2bf9d5e105b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:76927c85-3d26-4ab9-a31b-3561b0c528e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q16322"}
{"id":"9f60c78f-739e-4b27-8880-c2e584cd1afe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:5287","sources":[{"id":"urn:uuid:34747fb0-fe32-4075-91b9-52c86f947150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:O00750"}
{"id":"45b2c0ad-144b-4a05-a65d-695f227c4949","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41633","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:172c3995-3f76-456f-a6e6-8d42476db90f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2751","original_object":"UniProtKB:Q13133"}
{"id":"bba77907-93da-49ac-82d4-3dd140e6f87d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135457726","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:8b2016bd-e82d-4ad6-8229-a2155d6fcd65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5238","original_object":"UniProtKB:P42574"}
{"id":"c0575e04-eaba-477b-9a53-e3beb952e4c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6129","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:f19c4408-bfb1-44cf-88bd-7d7feedd75a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6661","original_object":"UniProtKB:P35354"}
{"id":"bfc0623a-a3fc-46f3-961c-877bb8cc9bbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080871","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:214c03ed-6416-48c8-b4c3-0d7eb8e9b6c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2179","original_object":"UniProtKB:P37288"}
{"id":"f78f7de2-9aea-4490-a9f0-7c51871699a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4K446Z8N51","predicate":"biolink:affects","object":"NCBIGene:8726","sources":[{"id":"urn:uuid:f4a180f7-9075-4ee4-9b0b-a163a694c36c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10515","original_object":"UniProtKB:O75530"}
{"id":"ace5ab58-da63-42c4-882f-2beddd63324a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1297","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:419e3e71-6fc2-4e19-acfb-8da247755c1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1297","original_object":"UniProtKB:Q99705"}
{"id":"d2a0725c-e56c-4a0e-9af6-b6e6d86c74ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:4f9bd534-f7be-4a86-a52b-780e20942748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P47898"}
{"id":"4d8981f2-e1e5-4cba-9bb4-895147da2901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124226","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:0c9f8a34-714c-415f-a9dc-c28670f2a9cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:322","original_object":"UniProtKB:P08173"}
{"id":"0a3b3164-9520-4c54-a770-8f815641ccd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16652","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:994d3f66-11d2-49c5-97e3-811c21d27cd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4137","original_object":"UniProtKB:Q9UHC3"}
{"id":"6b542049-4038-41bc-b5bb-be73858f2667","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755087","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:37ccdc01-0da5-4dad-9ba4-e7c801bbd5ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4223","original_object":"UniProtKB:Q14643"}
{"id":"64f0cab9-060b-415f-946a-8c495d21ecdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80229","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:adb1e963-85da-49e5-a29c-d88c0aa0bd2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:616","original_object":"UniProtKB:P21729"}
{"id":"43e9a55f-0b4e-4925-8e14-dc8d63e82ca2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5780","predicate":"biolink:affects","object":"NCBIGene:12273","sources":[{"id":"urn:uuid:e44ecbb9-9f73-4b8b-98e8-cffbe2e2759a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5780","original_object":"UniProtKB:P30993"}
{"id":"64bda32d-9341-49d5-a70a-e378696ec17a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:cf3d8c64-d0a0-4bb8-a873-e0faa7ed7aaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:O08726"}
{"id":"650fa8b2-8592-4f8c-a41a-1a9c26c50b29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3853","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:59dda652-682b-4446-ad45-3874ceae71ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3853","original_object":"UniProtKB:P21730"}
{"id":"e6ba3fc0-3d81-45ae-ab2b-c5ca7e74f520","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2583","predicate":"biolink:affects","object":"NCBIGene:56543","sources":[{"id":"urn:uuid:95f5167a-f806-4760-927e-414c69ffd454","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2583","original_object":"UniProtKB:Q9Z0V1"}
{"id":"f5680e91-d1c8-4229-a802-5cd656bcd2d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:896","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:795e7766-af80-4ea3-99ff-ac36e52bfe84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:896","original_object":"UniProtKB:P30553"}
{"id":"eb38dfbd-0050-4b45-a23c-3f56d8147df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AZ9L8ZYZ3A","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:aec49d10-5619-422b-97fb-9e9c8c595af9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:934","original_object":"UniProtKB:P21728"}
{"id":"3b9b2b52-b117-4c57-831f-0c0c2d159dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11474","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:9bebf0ae-5a3b-4871-a21d-728bb75fcc97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11474","original_object":"UniProtKB:P78348"}
{"id":"52ac460a-3823-4c2c-b6e9-93dadc4bdc6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030528","predicate":"biolink:affects","object":"NCBIGene:3688","sources":[{"id":"urn:uuid:3db47178-83be-414d-87f2-1071a51e480f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10450","original_object":"UniProtKB:P05556"}
{"id":"323ee013-b633-4a0f-b80b-1c713bf7fa07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92918","predicate":"biolink:affects","object":"NCBIGene:10645","sources":[{"id":"urn:uuid:c767100b-bb50-4078-a07a-0af77810977c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5274","original_object":"UniProtKB:Q96RR4"}
{"id":"714a1f70-d436-4b72-aad8-9043d11b5556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:57582","sources":[{"id":"urn:uuid:58af2725-74d5-4c87-afcf-befd73a5e8ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2342","original_object":"UniProtKB:Q5JUK3"}
{"id":"7b7170c4-ff2d-4d40-8d40-3aa1b915c073","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:7a331ca6-39fe-4a49-a753-e98c783b8570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P08908"}
{"id":"bec7ed08-1de5-4aa3-9656-f3955cbe6e0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N0A21N6RAU","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:242f42ef-c30b-4938-974b-041c67a19a70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10432","original_object":"UniProtKB:P29597"}
{"id":"b48ad1eb-3165-4b23-bff3-de8f2a46e9a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2389","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:38165efc-3704-4f1e-9bb3-8dbf5fff31ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2389","original_object":"UniProtKB:P35561"}
{"id":"e3af23c1-3a1a-4020-a684-82db4ad725a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:51305","sources":[{"id":"urn:uuid:a0765a39-90d2-4f39-a890-4ca3a7c8f67a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q9NPC2"}
{"id":"c4b07009-b121-4388-9267-362ea6c166a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:64CW205BDD","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:f336b096-bc57-4c99-8991-ce03d865ecae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9800","original_object":"UniProtKB:O00329"}
{"id":"ce549da1-13a2-4356-a756-403cad7221d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38322","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:5e96253c-61c5-477b-a79a-dd89eed3f8eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:303","original_object":"UniProtKB:P08482"}
{"id":"45b6edf7-ea48-4cc9-b08c-287a3ebeeb1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:391960","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:8bb16564-891d-4f9d-8fbc-c9103702aa14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:321","original_object":"UniProtKB:P08912"}
{"id":"badf69ad-26d5-4dca-a835-c46653a3f94f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163839","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:1987ea4a-7923-44c5-acca-81fb3241ddf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:268","original_object":"UniProtKB:P32305"}
{"id":"d816c632-5558-4da6-b81e-23e2273e398c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M18T0TD14","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:61ea6b15-01de-4793-b087-bc5807c4e28b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1620","original_object":"UniProtKB:P41145"}
{"id":"cfe78c4c-0745-42ae-b0a4-e88ba2784944","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11646823","predicate":"biolink:affects","object":"NCBIGene:108071","sources":[{"id":"urn:uuid:a69f45f8-9db4-49a8-b490-cec26e7c6dd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6409","original_object":"UniProtKB:Q3UVX5"}
{"id":"006b686a-ea7d-4c70-9d8f-d12fab67efc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:366","sources":[{"id":"urn:uuid:c583c44b-d13a-48fc-8913-b78c60b7a44f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:O43315"}
{"id":"073deed4-972e-46ee-855b-eae7294dd386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70707","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:dafe5dd4-356b-4777-8147-ccd551a4263b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7427","original_object":"UniProtKB:P08908"}
{"id":"5144bb60-dde3-4f97-bb24-fa954000a8f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2275","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:4cacbc45-3684-45ce-b67b-c1309ce35ec9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2275","original_object":"UniProtKB:P35000"}
{"id":"91b1007c-06a6-4a20-acd6-a8065e1564a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3FWQ4MD98O","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:f0a13858-3dbe-47d7-935e-f79ad14c3fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1178","original_object":"UniProtKB:P30968"}
{"id":"79a8a93d-e05b-4912-8b35-9fb295628330","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:628","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:00fd23b8-9f97-4816-bcc3-9c40dd938be0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:628","original_object":"UniProtKB:P21729"}
{"id":"8a45aad9-bd69-4a3c-8447-773c9968a30c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:f74c9532-b0b9-463c-92eb-2f135f03fd8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P08172"}
{"id":"5d27fc90-c910-4fc1-8673-d3969c76ea27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:7eaca1cb-6028-4d9e-884f-e4f97051d9d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:O08726"}
{"id":"53bd2a1b-ff06-4406-8619-3feb85da88dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699447","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:6bdfdbbb-30d5-4343-95de-dbf9c1baadb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11144","original_object":"UniProtKB:Q9NYA1"}
{"id":"b9b0f831-9a48-492c-afa4-80e8e3d41cab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755014","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:8fa793db-3e7c-4125-b0b5-0e84bf6ca2a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1840","original_object":"UniProtKB:Q62035"}
{"id":"854d9413-ec32-4d99-80ba-7e7134a928d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60207864","predicate":"biolink:affects","object":"NCBIGene:350383","sources":[{"id":"urn:uuid:2fde682b-908d-49b6-9f2a-1230dee2356d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8791","original_object":"UniProtKB:Q7Z601"}
{"id":"eb382fc5-5327-43d7-b3ec-eb59c137804d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:564AW1RR37","predicate":"biolink:affects","object":"NCBIGene:84876","sources":[{"id":"urn:uuid:336c6ebf-27df-4600-af70-1400c4cd4bfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10087","original_object":"UniProtKB:Q96D31"}
{"id":"cd760e26-b411-405a-b97c-b64052f6dedd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:b8e7eaae-5d4c-49a3-96f6-d17dbc7c7bf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:Q9H228"}
{"id":"5cf4fc46-65fe-4262-81cb-4e6d955a418f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44374901","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:ea0c87e6-c1ce-407b-91ca-6905bb52485d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2990","original_object":"UniProtKB:P04035"}
{"id":"8b73daf3-cc35-4fac-b1ba-f8198c48a9b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4754","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:74c75618-c7e9-4197-8fb3-06f0d9beccee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2446","original_object":"UniProtKB:Q9NQA5"}
{"id":"266994c3-3d6a-432e-9f4b-0cfe491fc7e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16109435","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:1df935c4-23c5-474d-8a09-669a042c6fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5607","original_object":"UniProtKB:P29274"}
{"id":"865aa7a9-fa00-4c90-a168-a45b5b9e5adc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33569","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:dfc2d1f9-0b2c-4a69-81f1-7d41373f56d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:484","original_object":"UniProtKB:P07550"}
{"id":"d1e83048-ee6b-4a59-982c-d09a08f69f7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44309215","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:f6ca1302-fd65-4f61-af95-158153b4dc8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1635","original_object":"UniProtKB:P35372"}
{"id":"4ad890e0-28d3-41c1-b3bf-141b00b92b6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:e10d14ff-d70a-4245-9126-bad99b67a936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P25100"}
{"id":"ce685ba5-c33e-4982-a2d3-0b8931ef05b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:04XB9TB8OL","predicate":"biolink:affects","object":"NCBIGene:309212","sources":[{"id":"urn:uuid:588e6c2f-1cc4-4fa8-b6f8-c53a23e9a59d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9277","original_object":"UniProtKB:Q6XKD3"}
{"id":"2d268c34-e52d-4f56-af82-132a080f11df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:a578b386-401a-49a8-9e7c-d6650ff77a89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:P49841"}
{"id":"e96831e6-9504-4292-b4ac-ff4da3fe4ad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PE952ANF83","predicate":"biolink:affects","object":"NCBIGene:6401","sources":[{"id":"urn:uuid:388d5e35-3f82-4f3b-b72a-9e9b66a15046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11995","original_object":"UniProtKB:P16581"}
{"id":"80dbc21b-04c8-4ce8-beca-51bc18038ad4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:9618ab9d-1e74-4179-9d8f-0af25fbea9a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P34969"}
{"id":"e6ce3ac8-18e4-4862-972a-2d4ee2dc59ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2155","predicate":"biolink:affects","object":"NCBIGene:217369","sources":[{"id":"urn:uuid:cb54215a-7570-47c2-b535-333d1a031d04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2155","original_object":"UniProtKB:Q8VIH9"}
{"id":"09250e06-65a7-4236-8d67-0e2701cac01e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135847","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:7b55c837-2cac-4c94-9493-be505d663fed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11741","original_object":"UniProtKB:P08183"}
{"id":"4a3a7830-78b8-4fd3-9688-65abe06d730d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817400","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:d6665219-09b8-452c-bfc0-1b9d61ed52d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1280","original_object":"UniProtKB:Q969F8"}
{"id":"65966838-6df2-4a66-a667-3fb83b70f1ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2LHZ9ZC3YO","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:feb1a436-47a4-45e1-bbd7-b1d324354fa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12704","original_object":"UniProtKB:P98170"}
{"id":"badf12e8-a536-4486-8d6e-5c1f6d3d529d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:13OB0KEU61","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:61fa10d0-6c8f-4c09-87b8-2ac1ea17e366","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1075","original_object":"UniProtKB:Q9Z0U4"}
{"id":"05c2c7bc-308f-4cb7-b2e8-0d9121717c1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311240","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:d14f9b2e-c0e5-4576-98a3-cfcd37773994","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1955","original_object":"UniProtKB:P43088"}
{"id":"b7ad77d0-14a6-4520-b92c-1d01d84669d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73358","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:54927b64-ec37-4e99-a52d-28aee4bd7d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1652","original_object":"UniProtKB:P34975"}
{"id":"ab03c7ac-f192-4994-a849-6991d64dbce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:96265TNH2R","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:f10e363c-dc6f-4cd7-bff1-a1819c33458e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7940","original_object":"UniProtKB:P42345"}
{"id":"2300d1d9-7bc0-4223-8932-439dc5ebf2cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M63IS9PTJF","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:bcfcda3e-89d0-4440-9c21-011a73d9516e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8476","original_object":"UniProtKB:O60674"}
{"id":"24c96a7b-6a63-42d0-a372-cf5e5cd95f04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8407","predicate":"biolink:affects","object":"NCBIGene:3695","sources":[{"id":"urn:uuid:3807e62c-d807-4cb6-925c-9cc5843e7aa2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8407","original_object":"UniProtKB:P26010"}
{"id":"fbaa14ce-7935-4951-91fa-74e0cd3fc7f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190022","predicate":"biolink:affects","object":"NCBIGene:5338","sources":[{"id":"urn:uuid:35ad236d-4490-46a9-a48d-bbbd08a4a542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8781","original_object":"UniProtKB:O14939"}
{"id":"a50ba2fb-56f0-4790-884a-f363ef3c9a39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6780","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:4c126c16-8f4f-4a23-adb4-8f9849c4c36f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7227","original_object":"UniProtKB:P28335"}
{"id":"e955fa28-e5f2-44e0-afae-3d11896f1d38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2563","sources":[{"id":"urn:uuid:4235a4df-0fbf-418d-ab20-c42a72db3778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:O14764"}
{"id":"75ec3873-c839-4c13-b607-ce51a5b293ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73358","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:34f838df-7a68-43af-b538-f6622dd8c89f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1652","original_object":"UniProtKB:P41145"}
{"id":"e56cb617-ddb8-4ab2-a6c2-267f6e0d34e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10361101","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:8642293b-376e-4ba8-a0e1-e9d8c82a7b53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8194","original_object":"UniProtKB:P37173"}
{"id":"c8ac3388-7ca0-4812-a227-4587643688b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63451","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:56ce2a80-ca45-4202-9300-85b6246e8857","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7877","original_object":"UniProtKB:P11362"}
{"id":"4578d180-85f4-423c-b406-7686149fc29a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827360","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:35229a01-ceac-433a-9d7d-c93b8e09fc72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8422","original_object":"UniProtKB:P28566"}
{"id":"4d3d11d6-fceb-4298-bc47-39689fd2a4ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:040f1347-b9cd-4b5a-8798-708f10d35cb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P29274"}
{"id":"a49cc6ef-ca31-45f1-8686-0d32548bc386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13786","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:bc763163-483b-4ec7-82c1-f3aa8e3238a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13786","original_object":"UniProtKB:Q8NBP7"}
{"id":"f3748092-4d24-4adb-9131-570100f69010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95077","predicate":"biolink:affects","object":"NCBIGene:8242","sources":[{"id":"urn:uuid:0f12d290-93db-4eef-aa95-dbeb9ed0ceea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8979","original_object":"UniProtKB:P41229"}
{"id":"d5735d76-1440-43f1-b9b8-5367ee4ee05c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8391","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:5c7a3ed7-bb3e-4b64-b368-602651b2deb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:537","original_object":"UniProtKB:P08588"}
{"id":"a59482c2-4228-4387-8d4e-c2d5cd923f14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73659199","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:01fcf0b7-62cc-4c03-a103-4ea6acf5ecbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10234","original_object":"UniProtKB:P48736"}
{"id":"f7bcdd92-f769-49e7-965f-2d78cc5d236d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125516","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:b2f2ab7b-e8e4-4a34-b295-53f387d6ae86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1582","original_object":"UniProtKB:O95665"}
{"id":"860bfe26-c531-4fda-82f5-1cae8f3aa4f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:50eaaab5-e012-43e7-acd4-da50d723f6c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:P07333"}
{"id":"23aa423c-c3a4-41ec-b325-879391181fe4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91790","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:42d064a1-6533-4689-8767-d2c2a58c358f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:186","original_object":"UniProtKB:P28335"}
{"id":"25406e20-e9b3-4ee6-9604-daca72ad3203","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321166","predicate":"biolink:affects","object":"NCBIGene:6258","sources":[{"id":"urn:uuid:f41656f5-541f-4062-8fe6-67a784c466b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10186","original_object":"UniProtKB:P48443"}
{"id":"0490103e-2460-4d2b-8e1c-a88f017aac28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9817231","predicate":"biolink:affects","object":"NCBIGene:69071","sources":[{"id":"urn:uuid:d007036c-4b0f-4777-93b7-57d7980ac809","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10731","original_object":"UniProtKB:Q8VD00"}
{"id":"e966c2b8-f52f-47a2-9dcb-043ac0f2eebb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:4058","sources":[{"id":"urn:uuid:2d84c93b-cbe8-45ca-9a62-f2baa9d722fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:P29376"}
{"id":"a3d6fb4c-ba1a-40ce-9caa-aa5fc841320f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91972027","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:fb04662b-4915-4e58-ba56-cf0823ea6457","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10030","original_object":"UniProtKB:P21554"}
{"id":"847bfe07-a9b9-4049-ba73-672e548df5ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:acbdc4bb-d278-4b9a-9bf7-aec69be18053","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P08913"}
{"id":"83fe6ce5-4d72-4f41-8b45-6eb854e6ce94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:14e6fb29-14f6-4b5b-95d4-e93d5c40e8c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P14842"}
{"id":"3c55e9a1-881d-43e8-a04d-9f9ad8998751","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:c98651f6-52c0-45e2-b7cf-8f95346a9af7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q92952"}
{"id":"657b4bd1-e46f-4aab-b78a-0076f59aeb8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:9549f9d5-fca7-4338-b608-1383666e5a04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q6RI86"}
{"id":"ba380366-f429-4e5d-967e-0a3f1e0d08bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:7a0a11c0-ca42-4a0e-8547-bd1d71ed4924","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P14416"}
{"id":"e9243395-017e-4bc6-88a8-214dba7b9829","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8534","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:1f73731e-e1f4-4442-b221-d0c3b032d73b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8534","original_object":"UniProtKB:P61073"}
{"id":"c577affc-4eac-46a8-934d-125372f6b530","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166532451","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:cff127a6-1063-467d-9100-1d44d8de57f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12903","original_object":"UniProtKB:P42336"}
{"id":"542a3e24-68d2-4135-9dd2-5e6b5b95720f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33216","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:5cd87e39-6b0d-43dc-948e-d7af2ab2bf8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7865","original_object":"UniProtKB:Q92731"}
{"id":"2195c477-b119-41b5-bf6e-152786aa8695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64310","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:2251f044-be19-424d-bb6f-fa10e866d326","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4903","original_object":"UniProtKB:P08581"}
{"id":"a933c881-2f98-4d38-b9c6-c8a8ed36aca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94140","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:1efe79cb-be48-4e07-a957-693756bf9bbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6025","original_object":"UniProtKB:P05771"}
{"id":"0ddefda9-4bf6-4b52-b723-4f4253385fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:81fbb5c5-791b-48bd-b6ae-eeacf6b4b42d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P30557"}
{"id":"38dec40a-53a0-4a5c-aef2-ad7bd0b27b50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:18439","sources":[{"id":"urn:uuid:8d0c7d5b-5bc5-41d9-b5dc-f21298e20386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:Q9Z1M0"}
{"id":"f5c25744-5eca-41e1-a56a-d84ae7ba0289","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1255AT22ZJ","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:3b77486a-75ea-4a20-b452-1c677365bfe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11686","original_object":"UniProtKB:P50750"}
{"id":"8fc9b6ae-ed42-4843-85ae-6d900f8ff688","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135652","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:5dabfdb5-adc8-4e9c-8d0b-f1cd89a50e41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12488","original_object":"UniProtKB:P61169"}
{"id":"1f1782ce-59e9-4d6d-bbf6-87b233d9bdc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817480","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:cbfe58f8-8301-4c7d-8956-a8c8d4f2e7aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6091","original_object":"UniProtKB:O60755"}
{"id":"171840f8-211c-4c25-b87c-5a936b622614","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311387","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:b136c011-3b5a-436f-9fef-0ebe89792d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1970","original_object":"UniProtKB:P21731"}
{"id":"ecb7cc4d-498d-4b70-a9ff-05fb9af73af9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8GZG754X6M","predicate":"biolink:affects","object":"NCBIGene:945","sources":[{"id":"urn:uuid:43905513-a281-4df0-83e4-049fb0723579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6775","original_object":"UniProtKB:P20138"}
{"id":"900037d8-9359-4179-aa9c-b020dd125d4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2209","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:9db30d5d-6e3c-49da-8dfa-60c4da952091","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2209","original_object":"UniProtKB:P30518"}
{"id":"5556388b-2be5-4023-80d1-33a78fb29d95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72707143","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:f7511923-5c2d-4c4d-9b1a-87752a49ecc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11695","original_object":"UniProtKB:O43614"}
{"id":"46d0bc98-f87f-4345-9986-1d2a35d2d5da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9690136","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:d5ea5544-5743-4ed6-bdec-55c0ac5d3b25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2192","original_object":"UniProtKB:P37288"}
{"id":"292af3d3-c70d-4777-99a3-c4125372cbda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162477909","predicate":"biolink:affects","object":"NCBIGene:6789","sources":[{"id":"urn:uuid:4a23578b-0c59-42a9-9cc0-e616e8fa223e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12168","original_object":"UniProtKB:Q13043"}
{"id":"f726aa07-348b-448c-aa2c-33330f8a910b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5487427","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:79bccbfa-1076-4292-ad94-8efb809856f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:367","original_object":"UniProtKB:P08912"}
{"id":"ffbba7b5-9de8-4468-8857-67922a96be55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:25U4N985O2","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:e0acf016-252a-4f06-9c8a-9958c6ed2ff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10723","original_object":"UniProtKB:Q15858"}
{"id":"57a4f50d-4fcf-4d8e-b871-d47ac987c748","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:5b4f930f-2622-4e21-a18f-1d1a979079e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:P52333"}
{"id":"f35d43c9-4df6-4297-9282-6486660af949","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:bf03241f-3ffb-4dc1-9d30-2a0a4f5b08a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4192","original_object":"UniProtKB:P34903"}
{"id":"72453960-a8d7-485f-8346-083813c62f4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10058","predicate":"biolink:affects","object":"NCBIGene:7296","sources":[{"id":"urn:uuid:840ed0c0-ba15-4ec2-97a3-c7b296c6470c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13700","original_object":"UniProtKB:Q16881"}
{"id":"0bb7d3b9-a7be-4762-ab21-98d84f2ec4b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135333","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:3c803b8a-0405-446b-ab9c-864c264e848d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9743","original_object":"UniProtKB:Q9HC97"}
{"id":"3836c77d-6299-4aac-beb0-a52e9d4d529a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25147760","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:ce12cbc5-5547-4bdb-a700-19b97f4010b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3072","original_object":"UniProtKB:Q02769"}
{"id":"bd6e7d3d-4e3b-4018-a1d2-daa3e47f6f95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X46FC5N190","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:669baf82-c223-4378-bf18-0fbbe1eff8c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4209","original_object":"UniProtKB:P42261"}
{"id":"e783d6e3-3c66-4420-9ce2-d3e6f85da5d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311371","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:bc4f27ee-c7ab-43bf-8961-9988adc85c98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3513","original_object":"UniProtKB:P31391"}
{"id":"55211fc5-141e-4f93-a905-6a7edbbeeacc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:7bb02ba2-4abe-4b1e-8769-07706ea911d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P41595"}
{"id":"f8aaa8da-e818-4bdd-9924-19bccfd40d91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194340","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:ef9a1e43-7ee5-41c3-9498-25702874cf5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12647","original_object":"UniProtKB:Q9P0X4"}
{"id":"dce4373b-196a-4fb7-a274-731b83f4664c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124003","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:f3f65173-dbf6-46c1-8f86-57da69bfdd92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2116","original_object":"UniProtKB:P21452"}
{"id":"e13976d5-a9d5-4ce3-b047-1979b1be062a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90656230","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:796396c6-23c5-4b23-9fef-3ea17866eb91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9469","original_object":"UniProtKB:Q15077"}
{"id":"756864c4-70ac-47b9-a553-147e5858c563","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2258","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:0089c9c8-3f3c-46e5-b54c-61bea248f034","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2258","original_object":"UniProtKB:P41587"}
{"id":"07b3b27d-d171-40ff-af49-f38201eb7ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17211","predicate":"biolink:affects","object":"NCBIGene:81727","sources":[{"id":"urn:uuid:d38922bd-e318-4169-80af-e31d938b5b0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3051","original_object":"UniProtKB:P17256"}
{"id":"b4ee54c6-2646-4515-9ce0-ae1b0875033f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155411202","predicate":"biolink:affects","object":"NCBIGene:10524","sources":[{"id":"urn:uuid:3bc90af6-70c4-4440-b012-e8257ad785a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12938","original_object":"UniProtKB:Q92993"}
{"id":"bd95da98-539e-4f25-87e7-4c41bcdf89a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Z3QHB00LB","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:2081b93f-6599-4a24-a50c-b32295cb8c07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8383","original_object":"UniProtKB:P42336"}
{"id":"6f2d87e4-751a-4662-b7f8-4413fd2ae2ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9592","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:65f2e282-df1e-4df6-bc03-c5207105622d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9592","original_object":"UniProtKB:Q15116"}
{"id":"223fe3b3-4fa2-4872-a664-bb2f92f810f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:0b094041-db94-4625-897d-569cc65eeb0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P18825"}
{"id":"32846be0-7584-4de8-8bc6-730cfa670213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TT3345YXVR","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:cda4ca30-5b9e-4cc5-9f6e-c88f32a23cd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10052","original_object":"UniProtKB:P05164"}
{"id":"d52051bc-de80-46ac-a98a-7f8d3b12bbd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:160283094","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:70033ff0-2e8d-4bfe-9740-36de9b69cf30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12387","original_object":"UniProtKB:P04626"}
{"id":"ed65e316-19f1-4082-891a-d078dfab21f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311230","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:ee9dde1b-54f0-40be-a0dd-b59093cf65c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1933","original_object":"UniProtKB:P30557"}
{"id":"e666ba5f-96ff-486f-a60e-7be035089cbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2525","predicate":"biolink:affects","object":"NCBIGene:777","sources":[{"id":"urn:uuid:077bbbe9-c31f-4cbc-af09-60c66e223894","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2525","original_object":"UniProtKB:Q15878"}
{"id":"67d54cc8-2977-4b97-9114-a7f6d1a96b16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6SVX956NTQ","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:957424e9-5f3f-4ba5-9919-b2a9235e4216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:546","original_object":"UniProtKB:P08588"}
{"id":"25d9f04b-04b2-46c7-9dc9-23d5292df4dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:199e0ce0-b1b8-47b9-8b73-ca3fe5fba738","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P47898"}
{"id":"7df36718-4320-40b5-9e7a-ce4a09d70e0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83766","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:e0ee3611-9b2a-441e-8f9a-3f115bac8fe4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7519","original_object":"UniProtKB:P09874"}
{"id":"02d9cc42-eb8d-41b6-8abe-10ac4cd796e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167654","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:bf0c4f42-7b63-488a-9bdf-1b010c3f8295","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3381","original_object":"UniProtKB:Q9Y271"}
{"id":"abf46fe4-ac84-4c85-942f-8dc2f9df9a46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:02c54758-1d0e-42c0-ba7d-35c81c926af5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2645","original_object":"UniProtKB:P10276"}
{"id":"2043acea-379a-4c43-9e94-ae9304c486c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44241","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:0f15bd7c-efd3-4cca-a174-0f7ec2a4295f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5224","original_object":"UniProtKB:P19099"}
{"id":"2b5a71e1-22be-41fb-bae9-2c81e7aec6c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E1V875I8DX","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:422093f9-76d9-4349-ad43-6b32b3c4de48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6057","original_object":"UniProtKB:P35916"}
{"id":"ec4a1f81-f214-489f-b766-859c9559c35e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2611","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:61f2bd90-2205-4371-9740-3c5a5fefb0ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7111","original_object":"UniProtKB:P14867"}
{"id":"68325bac-fdf7-459b-999a-dd8945af6b83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188525","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:26f105d8-1ff7-4e52-8d35-09fa8f9c6695","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:46","original_object":"UniProtKB:P28222"}
{"id":"ae9d1def-5120-48df-a99f-dfe07b40e396","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13918","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:4fda66bb-43d9-443d-a7ce-2ed06c785b8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13918","original_object":"UniProtKB:Q12866"}
{"id":"c1a415ef-73f5-46b7-8775-00ca2e862452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1383822","predicate":"biolink:affects","object":"NCBIGene:4780","sources":[{"id":"urn:uuid:a9112a61-b69f-4f2b-9907-e516a862de12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10154","original_object":"UniProtKB:Q16236"}
{"id":"fcea8e1c-8cba-45bb-a177-20945c48b606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122669265","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:2b5ba656-64a3-45ac-9daa-f34bc4639e8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10528","original_object":"UniProtKB:P51449"}
{"id":"e741ae32-0f75-40d9-b4e3-2e24c4925a18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9599","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:9406a76f-af26-45ae-83fe-d16d65b7fba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:565","original_object":"UniProtKB:P08588"}
{"id":"d5cc5630-7052-434e-a37c-b16718d4de0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50922685","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:5bceadf3-6dd9-4d8b-958d-6fa17211bf2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9294","original_object":"UniProtKB:P41143"}
{"id":"eb90dac6-6b3e-49fd-8f84-dd2243769c9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:29571","sources":[{"id":"urn:uuid:f287ad1c-7082-4c59-aa06-81f04134893d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:Q62968"}
{"id":"a3f56534-fe29-48c1-940b-9aeff7047ce3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7582","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:2216281d-3956-4a20-b6b3-d0dfb4232347","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2334","original_object":"UniProtKB:Q01668"}
{"id":"dfefd4e1-1e7b-4b09-89cc-abc7bd80955f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3008304","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:4a9d1385-8e4c-408d-86e7-d481ab22093a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7632","original_object":"UniProtKB:P11229"}
{"id":"19fb0e41-85c3-4e5c-974d-67fac057e354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13699","predicate":"biolink:affects","object":"NCBIGene:7296","sources":[{"id":"urn:uuid:16dca5c9-1788-4d84-ba12-da173ca2645d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13699","original_object":"UniProtKB:Q16881"}
{"id":"1d583a57-a1a8-4b3a-90e4-d786ee29add1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:93ed3151-188e-4feb-9434-b586d428fdaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:P43119"}
{"id":"f9026d1c-960d-4626-ac87-9794e728755d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34823","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:f7d75ada-8893-4148-9884-f5a12973093b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2599","original_object":"UniProtKB:Q9NR82"}
{"id":"495702b0-1eac-482f-8e10-cd076d4c5808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827346","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:798781c6-dcca-4ade-9f2b-fab4f86742ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5622","original_object":"UniProtKB:P30542"}
{"id":"9f28aef8-77b4-4a91-aaa6-fb8564b950f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:5be19bf3-defa-4208-bb0f-7aaae39b96a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"mixed_allosteric_modulation","original_subject":"GTOPDB:4366","original_object":"UniProtKB:P31644"}
{"id":"c431b72c-46be-496e-8bc1-5700f28c8ce6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38073MQB2A","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:44a9abc1-1292-4964-9fa2-e4563de1707b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8916","original_object":"UniProtKB:O00329"}
{"id":"9275fb43-b3fc-4125-a45a-d0dd0626b1e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:46D4HS9ODA","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:54eeb612-4646-4d60-9799-54939ac8e6bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9903","original_object":"UniProtKB:P06493"}
{"id":"1ddc7bc5-39d6-4ca2-aece-a9eb7bdf173a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:45a7eab8-c9d5-480c-8990-5ccd7f980fb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P28335"}
{"id":"c6dd4fd4-660f-473a-8b6f-1d2ccdc4d254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194135","predicate":"biolink:affects","object":"UniProtKB:P0AES4","sources":[{"id":"urn:uuid:3231d499-e89c-40fe-a82b-34265607a0a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10918","original_object":"UniProtKB:P0AES4"}
{"id":"7059310d-9b62-4499-9361-0e1dc4cfa7ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611896","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:5f2b1c36-d37d-41e7-9805-d46374c9386a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9999","original_object":"UniProtKB:Q15391"}
{"id":"96693828-7f72-4046-9e35-5cc8d38e9d4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:922","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:d668d94b-0ace-4dd5-b4cb-2f7ceeed3ffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:922","original_object":"UniProtKB:Q60748"}
{"id":"e2f2ea88-af73-4062-b7cc-cfa12490a88e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6073","predicate":"biolink:affects","object":"NCBIGene:778","sources":[{"id":"urn:uuid:7a10d672-316c-4415-88a6-b2ccb2847dae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4488","original_object":"UniProtKB:O60840"}
{"id":"dd24115c-03da-4baa-b88f-4f51b83b97dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZD6AG3N96D","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:7a014546-ccb1-4c4c-94d0-15975ebbb282","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:176","original_object":"UniProtKB:P28223"}
{"id":"9937ffa2-4693-4fd2-afb9-ff834ca04411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:87345","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:f1353466-70fd-4aa7-ad14-1f721dabe9cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4173","original_object":"UniProtKB:Q5XXA6"}
{"id":"d0edbf6b-cbeb-4c65-92eb-08c740339060","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90170031","predicate":"biolink:affects","object":"NCBIGene:25818","sources":[{"id":"urn:uuid:4e083ad4-5245-4df1-ba1b-31c1da04cd18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8483","original_object":"UniProtKB:Q9Y337"}
{"id":"8a23f73f-0a6e-4e68-bb75-f98bf602a64d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1HLS600135","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:13ef18d5-3e7d-414c-ab1b-b837732d052c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:489","original_object":"UniProtKB:P35368"}
{"id":"ba75aab7-640a-47f9-9038-8af2a43d6307","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91442","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:0ef0a48a-ca0f-4378-95db-43d5f00b5f03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9348","original_object":"UniProtKB:Q02763"}
{"id":"b2de13b0-7e65-4f6c-8382-f00be4d16eb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90389","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:be5f0f0d-3fd4-40a9-9d01-97c28852f9b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1949","original_object":"UniProtKB:P35408"}
{"id":"b0046bf2-8242-4aed-8ee9-0f3fea6c2786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FD2SWT2SDI","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:b2a41437-38a8-4d8f-b46d-3177d7b08763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6045","original_object":"UniProtKB:Q00535"}
{"id":"a82b7be1-b46e-4ec3-893d-5a1298bcb913","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64156","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:faf857ed-7873-4aa3-85ef-35ce366ec9a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1250","original_object":"UniProtKB:Q91ZY1"}
{"id":"68f1e599-7c92-49e9-a65f-257a9b9c9d63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:651","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:8a664c82-e3b7-46b4-ae79-86c6deb6320d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:651","original_object":"UniProtKB:P46663"}
{"id":"a940a5dd-7625-4ea0-b28b-a9f2eba0e873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10092584","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:43e44c29-495b-45b9-a8d7-e41a334e00cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3062","original_object":"UniProtKB:Q02769"}
{"id":"dcf14904-1257-48eb-aa67-87636a5d5287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4740","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:ed650c7e-0896-4215-98df-a2986b4de18a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:345","original_object":"UniProtKB:P08172"}
{"id":"f23ee740-809f-4e3c-bcb9-9b8da0677af1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195326","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:d3a47830-566a-4d84-baf3-11734fdfb9e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1323","original_object":"UniProtKB:P33032"}
{"id":"773b339a-91f6-4a5b-b954-3d8ff18db58a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4020","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:6a01b207-b7e0-477e-a371-19ca9775b2fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4020","original_object":"UniProtKB:Q9Y5X5"}
{"id":"232a0956-ca90-48e0-b3d3-d3b8729b866d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:10804","sources":[{"id":"urn:uuid:73556b26-d060-4da1-825e-ce19f56b5012","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:O95452"}
{"id":"09a55f30-1849-4db2-a35a-b47cf43ea128","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310996","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:74afb6f7-1537-4189-b982-5cf02df7856c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1755","original_object":"UniProtKB:Q9BPV8"}
{"id":"9e22ae67-4549-47d9-8fd0-e5c9cbeace09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:bda00d91-719f-40a4-a7e1-7079234bf77d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P08908"}
{"id":"ad2e5525-c709-4ab2-b75a-0046271c3c03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44915","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:d1f0122c-f7f5-4bc0-922a-29ef93da9ca6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5464","original_object":"UniProtKB:Q9HBA0"}
{"id":"db6ff4cf-78fd-4469-abf3-2c9a732d1eb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2028","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:f00c2ae3-c36a-4bac-9a33-9bf919875a45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2028","original_object":"UniProtKB:O08858"}
{"id":"30f867d0-1710-4cdf-9cbd-1c00f975180b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9654","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:bd88021f-8eff-4e6c-b3ff-d4ebe6373cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:213","original_object":"UniProtKB:P28223"}
{"id":"5cae44db-8fb3-4440-b884-49d0284e16ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66919","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:ffc67b86-1ff9-4f32-8f34-fc0f0935efcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5688","original_object":"UniProtKB:P23458"}
{"id":"0e84fd8c-d49a-410a-bf9f-17c57c6576ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1023","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:76592c77-9aeb-4d78-b527-635b0476d096","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1023","original_object":"UniProtKB:O88536"}
{"id":"0224ca94-5765-4a2a-a751-ea580ee81d8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95082","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:a9945c61-83cd-4a98-ab58-33eb837cdf1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7033","original_object":"UniProtKB:P25440"}
{"id":"e7021ac4-69ff-4a21-9426-cadd4283ff3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9822RX831L","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:efbd55f9-3d3e-412f-8332-ad4b18fe7568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4000","original_object":"UniProtKB:P36544"}
{"id":"0db7f003-c070-4c9f-b7b3-66233690ef11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49662","predicate":"biolink:affects","object":"NCBIGene:113235","sources":[{"id":"urn:uuid:cce2249a-b9ea-4b13-a371-53fac91f60cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1909","original_object":"UniProtKB:Q96NT5"}
{"id":"999ceb7a-1221-4c8b-b20d-4b00228e0aea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WXE3H7W295","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:e48a7570-d2fc-4b68-8bc1-7a72f0994655","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3240","original_object":"UniProtKB:P50406"}
{"id":"c9260390-c130-421a-8d34-cd321af070ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8762XZS5ZF","predicate":"biolink:affects","object":"NCBIGene:369","sources":[{"id":"urn:uuid:d04afd22-c4c0-46d4-8939-ba1b1930271d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8958","original_object":"UniProtKB:P10398"}
{"id":"aed7417f-0998-41e4-9a11-646fd3c61e76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:a5bb772c-725b-4753-83eb-436a046157e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08912"}
{"id":"7cd00c7a-83bb-493f-a6a0-9e1a2aa2ef36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90933","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:3bc084ef-3021-44d9-8d0c-e5ac444075ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7671","original_object":"UniProtKB:P14416"}
{"id":"17df2567-9225-435a-b412-e4ca3b4babca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151183","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:3ae3c031-a632-45a4-b239-09d8638d9281","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2677","original_object":"UniProtKB:P37231"}
{"id":"d607e263-202e-47de-b3e7-fbb7737583c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76609","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:6a7af4cb-61c8-413c-ab56-5ec2f0efd61c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10070","original_object":"UniProtKB:P25101"}
{"id":"b23b665a-7592-4661-8570-d0258e51762f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366965","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:c9312659-fc7a-4a42-9eeb-1899183fc0cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11732","original_object":"UniProtKB:P42338"}
{"id":"860e26f5-3cf1-4248-b17a-8e4463f1df6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TD3SSC2VDF","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:706da510-c06b-41da-a454-16abcd7932f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11959","original_object":"UniProtKB:P34969"}
{"id":"c5cee30b-37d5-4366-b5fb-4abd7fdbf0ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488758","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:ddd1cf75-ca53-4a32-bbd8-c12e98afa8d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10335","original_object":"UniProtKB:P34998"}
{"id":"07ad477f-ec74-4d66-aedb-5403616c1fb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135349311","predicate":"biolink:affects","object":"NCBIGene:2830","sources":[{"id":"urn:uuid:5fde649a-ac75-4bf0-a125-6aaeb22e5e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12666","original_object":"UniProtKB:P46095"}
{"id":"a06d6937-1155-48e8-84b4-0b4070bfb4a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92149","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:0023e293-16ea-4036-80a3-b314e8754433","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7381","original_object":"UniProtKB:P25100"}
{"id":"963b2e69-ff56-4183-af7f-221d234ffc93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J4DRJ9BFS1","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:ffb8e524-b4fd-4b9d-93ce-a5359af93964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6126","original_object":"UniProtKB:O43603"}
{"id":"604119be-16e0-47f0-94bb-cc65b149175b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92070","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:56b874dd-b13c-47cb-bb1e-b73e1ec18c55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:94","original_object":"UniProtKB:P35462"}
{"id":"2b9ff699-396d-4939-89a0-4f187e829415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:07f5e68d-fd9e-45dd-8172-96f91d616de2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P18089"}
{"id":"3c429246-068f-4c9e-a90f-e98e53403aed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64312","predicate":"biolink:affects","object":"NCBIGene:24411","sources":[{"id":"urn:uuid:b3021942-9b05-46b6-9846-1324d2c2c09b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4253","original_object":"UniProtKB:Q00961"}
{"id":"7dad6497-958b-4a8c-bb89-a89298221836","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13928","predicate":"biolink:affects","object":"NCBIGene:1508","sources":[{"id":"urn:uuid:05349fac-5094-4b0d-9610-d9a53acd6e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13928","original_object":"UniProtKB:P07858"}
{"id":"1f96e64d-dfe9-4e95-85a7-9718d684bd04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:75d999cb-14f7-4b2d-bea3-29a3ee2bca14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:Q00195"}
{"id":"f9745008-7c1d-4763-9c90-417f040d55b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10124","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:8f4d5069-0ccf-4079-af9c-f2fbae92f43a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:60","original_object":"UniProtKB:P08908"}
{"id":"4134304b-d86a-44a8-a40a-710001ec864b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2316","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:eada1ea1-8c9f-4ba0-b8ed-9c94da045554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2316","original_object":"UniProtKB:Q92952"}
{"id":"8bbf9298-25e8-426f-ba05-22101513e990","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101607591","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:54b49027-b261-4320-bf28-25350637ce8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:637","original_object":"UniProtKB:P46663"}
{"id":"5841f33f-24c3-443b-92f0-adf47e0544c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3756","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:d7478baa-fafb-4262-9359-f9a47ffee7ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6963","original_object":"UniProtKB:P34903"}
{"id":"5416786b-a796-4ade-a960-88d1d140f8a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6780","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:3f3d00e3-60dd-4291-ac73-788e919e8c53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7227","original_object":"UniProtKB:P35462"}
{"id":"5cf0504d-7961-4850-80b0-5d80bd811636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:68JR6NCI7I","predicate":"biolink:affects","object":"NCBIGene:17171","sources":[{"id":"urn:uuid:1072f3b2-b764-4c96-abea-8c22cda6513d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5579","original_object":"UniProtKB:P30554"}
{"id":"b49aeca8-f249-4069-a196-a561956f5659","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117902000","predicate":"biolink:affects","object":"NCBIGene:53859","sources":[{"id":"urn:uuid:906851f8-989e-4991-9e4a-5901abd5363a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9964","original_object":"UniProtKB:Q9WUL6"}
{"id":"5b1cb670-1ed5-4667-8d03-7452ce969aaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:775ce62c-cc18-4e23-acc9-67c2be102ec7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P32305"}
{"id":"274cbdfa-28c3-4f90-a373-65a29cebdc4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10410059","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:a14d2e1f-d5f8-42f0-9a82-a92b488bde67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6691","original_object":"UniProtKB:Q07869"}
{"id":"1ca0f243-0c40-437d-a572-91af6f1717e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:8d812df9-492a-40b4-9e98-dc85808d3e81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P23415"}
{"id":"a94eec62-8c3a-4593-9336-c9bc0445fc36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191854","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:9bd2ceed-f29f-4890-95a8-4e513eb6c906","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:738","original_object":"UniProtKB:P20272"}
{"id":"a93a1792-5736-415f-ae01-d29fd32cad1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44442431","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:66fb855a-4ed3-416b-9b57-b350fe0d6d34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6342","original_object":"UniProtKB:Q13255"}
{"id":"03a13e18-2bab-47c7-a48f-992ab43ad230","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16469","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:cb321739-1c28-4afa-bab1-b3ff19f6d1e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1013","original_object":"UniProtKB:Q92731"}
{"id":"13190b8e-0d29-4c03-918c-9e21a6f6432f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:59L7Y0530C","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:58957e70-bba3-497a-91e4-bf63079ea495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11619","original_object":"UniProtKB:P16234"}
{"id":"f9f6f3d0-ad45-466f-b2aa-adad750678d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71478195","predicate":"biolink:affects","object":"NCBIGene:22260","sources":[{"id":"urn:uuid:54a9e719-d354-4093-b83e-7b55b3f7ce49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8692","original_object":"UniProtKB:Q60644"}
{"id":"c77b62c3-1654-4f41-8121-3a7e867aae00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4199","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:daededa5-1d58-40fb-8dcd-754563ab01d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4199","original_object":"UniProtKB:P51788"}
{"id":"7982cecc-4ced-4058-a88a-249f1131159e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"NCBIGene:10298","sources":[{"id":"urn:uuid:30b28796-2f17-4dcb-a1db-d40f0babf94c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:O96013"}
{"id":"547031d9-e09d-41d0-811d-919753d2097a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9876120","predicate":"biolink:affects","object":"NCBIGene:1509","sources":[{"id":"urn:uuid:898a23e4-4084-476e-840e-4c4136fd1524","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6541","original_object":"UniProtKB:P07339"}
{"id":"e6f71f27-8b76-4216-a342-687d87e9d9e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:81025","sources":[{"id":"urn:uuid:59429f15-d316-482f-b12b-0b0e1f4e4d88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P57773"}
{"id":"787d3d07-043e-4b5d-a32e-b362dde2dfb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92203","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:99b015f4-8a99-4e25-bcb2-939659a11bed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9611","original_object":"UniProtKB:P43405"}
{"id":"b5d54bc2-aa38-40f2-8188-d16b330fccac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1180","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:b591de54-af7a-453d-b8e6-86676492af34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1180","original_object":"UniProtKB:P30968"}
{"id":"76014eae-752a-439c-a388-42f589e8856d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1522","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:d02be5cf-3a10-41cc-ac58-d950e9db1913","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1522","original_object":"UniProtKB:Q15761"}
{"id":"07baa495-cd45-4d85-9891-7068742a401d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15985251","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:e4f9ab31-1d9e-46f7-87bb-1f9496a550a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6335","original_object":"UniProtKB:Q13255"}
{"id":"635a1120-dc71-4277-9c71-abac40c881f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:58124102-e4e6-4c2c-8287-8e49769b62c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9BX84"}
{"id":"0f493ef7-04d1-44cb-81a6-0158399920ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:2b7b9e60-fefd-473b-be3b-c91e2452110f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q07652"}
{"id":"7b4ef073-aba7-4087-a1fe-5734697e6238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433320","predicate":"biolink:affects","object":"NCBIGene:284111","sources":[{"id":"urn:uuid:01cba374-f380-4337-9ebd-4909220a0396","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12851","original_object":"UniProtKB:Q86YT5"}
{"id":"62e0f3a3-c9e2-4347-aa05-07e4b49eec19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9985526","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:9db8a1b1-3055-40eb-b188-e075a9e77fe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:293","original_object":"UniProtKB:P11229"}
{"id":"056ced62-3341-4f14-bc57-f74cbb633331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1807","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:3fd6b9da-329a-49f2-ad85-c03e1ca67b85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1807","original_object":"UniProtKB:P49190"}
{"id":"b690b112-c8ec-45d8-aa8c-0b00f370d210","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5778","predicate":"biolink:affects","object":"NCBIGene:6559","sources":[{"id":"urn:uuid:df94aa00-cbdc-45f4-8fa7-f3d84f9602d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4836","original_object":"UniProtKB:P55017"}
{"id":"5a2b4027-c9b4-4622-93b3-9ae9b7193fc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:171113","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:cd12ee77-786e-431f-ae1a-8b45561dcaaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2180","original_object":"UniProtKB:P30518"}
{"id":"ec83c463-31b9-4253-80f0-c0c9c50a7311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4061","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:be5be821-5ac7-445c-b17a-13d77ac2b075","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4061","original_object":"UniProtKB:Q96RI0"}
{"id":"db874dc4-1fb8-4682-8df7-1a67eb9d9f81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77961","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:ba79408f-7a0a-4157-921a-1884a0c9322c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2916","original_object":"UniProtKB:Q92633"}
{"id":"eb679085-f0f8-4550-9f4c-5af32928f4f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:168845","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:26d4bd2d-cca4-40b8-bc98-1f6cab36f1a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2475","original_object":"UniProtKB:Q8R4D5"}
{"id":"d5cd497a-d6b4-4e4d-9b8c-a3aaab0dcc87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135470","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:119abde2-eb09-43c0-b5ed-d847fd87897e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:501","original_object":"UniProtKB:P35368"}
{"id":"f73b23b8-e2fd-4b3f-9399-84aa0cf88108","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:fa91eaa8-febf-4ad1-9329-c2d4108c5a44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:Q15761"}
{"id":"a5cfbbb9-f909-4343-bfdb-12f7002f1ea0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2183","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:eceec04b-70f8-4d7d-9db6-e66afeb3d00f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2183","original_object":"UniProtKB:P30518"}
{"id":"bdaa7071-3060-4977-9e94-ef589fdd5d8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92539","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:54e854df-f8ed-4239-8d64-271b6a0ed60d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9","original_object":"UniProtKB:P25100"}
{"id":"6d3e0c9d-923b-424b-83d1-1762a8d50c62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13553","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:547c39e7-ab25-4db7-81fe-1fa3ec4fcc53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13553","original_object":"UniProtKB:P28223"}
{"id":"a1eaaeb0-66fa-4a17-8872-0598ce3c6dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817411","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:a93694f8-181d-4d83-b333-05af37d92998","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1464","original_object":"UniProtKB:O43193"}
{"id":"cfb750bd-21c4-4b4d-91e2-b37cf8ad3aa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10025114","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:0bf67e46-77ce-43d6-b9e8-009dbaf37d6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4079","original_object":"UniProtKB:Q13224"}
{"id":"d43cc18e-d5a2-49b3-9829-2b94f9d30802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3698","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:2f7e605c-0286-4326-9097-9cef78ccf8bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3698","original_object":"UniProtKB:Q9HBX8"}
{"id":"d2fc5ec7-aeb8-4faf-8367-c0f9bd186d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2263","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:41c7c3fc-1580-48da-8645-7c284185e751","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2263","original_object":"UniProtKB:P32215"}
{"id":"e1219a3b-eaa0-46e6-8718-f8960ec17710","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:1558","sources":[{"id":"urn:uuid:f28a54f9-7d2b-412f-8227-a63e9e3e9385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:P10632"}
{"id":"110a168a-2ce1-498e-af45-318d78b2aa55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321169","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:409a7c88-9acf-49cc-b172-b6bbd07ff929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10198","original_object":"UniProtKB:Q96RI1"}
{"id":"059def86-1334-4af9-93fe-a15daabf9070","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90685","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:b0f0c698-aa38-49c8-bf1e-78fe5e65152f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9915","original_object":"UniProtKB:P53779"}
{"id":"e0317659-e88e-4a3f-ad40-0dbf034df776","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:5cbff0b0-2f21-4122-bce9-fa01574be732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30680"}
{"id":"f7887472-48b3-42e4-9448-e1a9de2802ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7454","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:0afa7a94-b423-4a35-b7f6-b38919a9e243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1663","original_object":"UniProtKB:P33534"}
{"id":"a48bdb0a-92e9-4b7b-936d-e75fc0fe0b99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4016","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:1ecb2a8f-ed71-4abc-a010-3b1bec2fa3de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4016","original_object":"UniProtKB:Q9GZQ6"}
{"id":"d7c5b7ce-791e-41f5-b995-4cba9db7fa57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10160968","predicate":"biolink:affects","object":"NCBIGene:9510","sources":[{"id":"urn:uuid:61f29b13-0caf-4b20-8624-0ff49c9cc5f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8663","original_object":"UniProtKB:Q9UHI8"}
{"id":"bc042410-f736-48ef-84ce-ceac5e929163","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124920","predicate":"biolink:affects","object":"NCBIGene:84444","sources":[{"id":"urn:uuid:debc5eb1-bf5c-4e72-bea9-4c22622d32ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7377","original_object":"UniProtKB:Q8TEK3"}
{"id":"6feb8900-ffe2-4654-9330-d98d9e199024","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1502","predicate":"biolink:affects","object":"NCBIGene:2832","sources":[{"id":"urn:uuid:14b1e123-c052-4e83-9609-b0c7a6013cc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1502","original_object":"UniProtKB:P48146"}
{"id":"fb69e7e5-7207-44ea-a2d0-f51d3191e0ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:9d07abb9-fa1e-4920-b2ac-050a475d0b92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:Q92769"}
{"id":"f2d955b4-2678-4622-8187-2e0cbb4639dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145997874","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:2e9b5f74-d466-4c29-853a-de4ba8fc0c37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13470","original_object":"UniProtKB:Q08499"}
{"id":"d61dc411-e9fc-41e1-a287-3d76a76ee8a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8326","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:90eb8080-a6ac-44d1-98e5-bbd62a887523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8326","original_object":"UniProtKB:Q9NSD7"}
{"id":"ffe1ef28-1af3-4a4c-bb05-e44fd9b0bcf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90665948","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:03743412-7bb0-4bd4-b48b-757de963ed88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9013","original_object":"UniProtKB:P97612"}
{"id":"a22c935b-9819-4a4e-a5c6-b26621e87394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78432","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:c26665bf-8cbf-462a-a650-397e08cde4db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7397","original_object":"UniProtKB:P06213"}
{"id":"6863aebe-3c19-4e37-b5bf-2b18feeb8413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67RM91WDHQ","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:a562e667-22e9-459f-961f-bacca443edc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7918","original_object":"UniProtKB:P36888"}
{"id":"f5c05704-29d8-46d3-817e-9ff10ad5267b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:7e5abf9d-e965-4ce3-91df-9b6f0e16141c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P28222"}
{"id":"1baece34-685e-4a04-9663-fa7a1eb2f008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188061","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:a794fba8-223c-4ddb-974a-1aceafda0728","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4339","original_object":"UniProtKB:O75762"}
{"id":"0b46a9fe-597e-4dc8-b251-8d255e776216","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6106","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:e7bb450d-ba4f-4f23-bf96-965e53962d3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6106","original_object":"UniProtKB:O43603"}
{"id":"035d01ff-1817-422b-9510-2abbeaab1164","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140427","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:a8b3bc1a-3529-4b85-804d-3c864b3ec2da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6458","original_object":"UniProtKB:P00734"}
{"id":"37486201-8345-498b-bf76-40f7cc15d189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93773","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:06ae8c26-f354-4c12-ba38-a1da6ea321ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9129","original_object":"UniProtKB:P15056"}
{"id":"36955f79-b2ec-40c3-80b3-d18dc6c9b37c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:8c1806a8-5620-4ace-b5ee-fd2f09e8b50c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P41595"}
{"id":"2a427f59-c0c5-49ab-ad68-75b979c50b5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:be4ba3af-cd9e-4aae-8ecd-c5375c750a51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P34969"}
{"id":"58255302-7afc-4df6-945e-feaee8dbb4f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10124","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:571f3703-5a04-482c-bf42-d5235d987c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:60","original_object":"UniProtKB:P28222"}
{"id":"ace2ed09-d913-4b64-854f-10c52cfdf41b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50942314","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:4d01456f-045b-47b4-8115-728e6ebca7d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8210","original_object":"UniProtKB:P08581"}
{"id":"48195a69-6d85-4001-8763-4b32d47d376d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5212","predicate":"biolink:affects","object":"NCBIGene:3612","sources":[{"id":"urn:uuid:e2060f9a-ddad-4c67-9060-caea8eee6a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5212","original_object":"UniProtKB:P29218"}
{"id":"b499a7f9-c55a-42ef-be47-2fe178e36c97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:108147","predicate":"biolink:affects","object":"NCBIGene:24808","sources":[{"id":"urn:uuid:192d0a61-4cea-40b9-8c67-fdc2c8a343f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2127","original_object":"UniProtKB:P16177"}
{"id":"cc46dded-f390-4f8c-b12a-afc00d751ef2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9948320","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:0cb64ab0-54a0-45f2-a5a6-a8fae895f067","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:289","original_object":"UniProtKB:P11229"}
{"id":"fdb8c531-35fd-4e2e-b08f-c57504c50d57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233330","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:14f4c2f1-5dd5-4681-8cab-883ab712469e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2335","original_object":"UniProtKB:O15554"}
{"id":"1636fe1a-7351-45f3-8c65-bfc436aba81e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:845e8d40-a279-4c55-bbfd-5d82973074b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:Q9JL06"}
{"id":"72da33f3-8405-4a4f-ae16-d9741afa94ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733031","predicate":"biolink:affects","object":"NCBIGene:260319","sources":[{"id":"urn:uuid:5c298672-91b5-4879-85ed-ba35bfc6fc33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11261","original_object":"UniProtKB:Q8K418"}
{"id":"f821d259-08e0-47d6-b9f1-f09c0036a240","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185785","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:f7f54ec3-d0a3-4a4d-86b2-9dd1ae671246","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9705","original_object":"UniProtKB:P20272"}
{"id":"bb5299ee-1905-4ff7-a402-f4d1fda63a79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10152528","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:d6975c6a-4301-448d-8c4b-cf76c8215a21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3424","original_object":"UniProtKB:P43088"}
{"id":"c4b6fb3e-3655-4621-9d53-ee6c46aaafcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9735","predicate":"biolink:affects","object":"NCBIGene:389400","sources":[{"id":"urn:uuid:9c219481-2c4f-46a3-b683-15dd3ab197f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9735","original_object":"UniProtKB:Q6UXV0"}
{"id":"4ff0e5fd-57bb-472d-9962-c5482bc67c10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6438","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:76f67971-44b1-4420-8a23-ebb3451e2e8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:570","original_object":"UniProtKB:P25962"}
{"id":"444a4fa7-d318-49db-aab5-0883d50b057b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177401","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:f446f995-1310-4a8a-ae74-fc6d0a88eb79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2886","original_object":"UniProtKB:O43613"}
{"id":"01c54ba3-8c13-4bcb-bbb0-d4b7fa56a404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GA36S2O9C2","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:2c75da99-9e94-41c6-ae36-946d52eade5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4245","original_object":"UniProtKB:P42261"}
{"id":"486b7a5c-0e0c-483f-95ce-9ee2aa2dd87b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6438","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:9b1cf28e-add6-479a-9742-beec1deb11d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:570","original_object":"UniProtKB:P26255"}
{"id":"01caac57-b516-4544-a07d-32a57854e9c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54613583","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:a46bfae0-a990-40e0-86d6-c2d4dd8d6037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8156","original_object":"UniProtKB:P11309"}
{"id":"7d7d1f50-cf15-42f9-b2b3-2f920ad034fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X05U0N2RCO","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:2313416b-49b4-43bc-844f-8260feb4fdee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10439","original_object":"UniProtKB:P15207"}
{"id":"da1e0d07-e11f-4101-b8f6-2e655efdc25e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2D9N67F58G","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:e11dfa67-ff31-44a3-966c-49018f686cd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5691","original_object":"UniProtKB:P00519"}
{"id":"b1a1af7b-a639-4550-acc9-89ffe4990b5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:ef5db1cb-ea5d-4e8c-b1f9-5f942766640a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P30966"}
{"id":"63583c3a-c346-4755-be14-e00ca0e61e3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11964458","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:916fbaf9-3ba3-41f7-8de6-25faedee864f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3992","original_object":"UniProtKB:P43681"}
{"id":"4785c594-e665-4a07-8b53-557613bd956c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:51347","sources":[{"id":"urn:uuid:be68b174-4186-4f85-a20c-ddc68c43ecfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q9H2K8"}
{"id":"66879a8a-d46d-4dc8-a883-69eea13c4130","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925845","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:1c3ec18b-7751-4d7f-8780-6919a5365bb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11533","original_object":"UniProtKB:O15393"}
{"id":"f76c4f0f-942a-4d62-b550-7ecd0578360a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5700","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:88a5530f-831e-450a-a039-a8f3483f46d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3963","original_object":"UniProtKB:P32297"}
{"id":"d235e426-4138-428a-9f35-8227fc3d863e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92300","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:ec3f664e-a252-41c7-a611-0c46fa15f4ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5982","original_object":"UniProtKB:P10721"}
{"id":"fd518af5-a35b-4835-9f94-72369b699661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OVW60IDW1D","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:9fbe1d28-bd6e-489a-8102-9b9ffd932c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10096","original_object":"UniProtKB:P42338"}
{"id":"467e6ec5-5ee4-4492-876e-6040d25eb9ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:759","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:a25c84fc-d5f3-47b7-9b41-722aae6b7f93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:759","original_object":"UniProtKB:P51677"}
{"id":"0032d116-a12c-460a-9fe3-71114bad2875","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169262739","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:48c8ce37-a32b-4e72-a00a-f32e442ecf8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13370","original_object":"UniProtKB:P04049"}
{"id":"e39ea47a-1cd0-433f-b417-a3a76cd75a69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:a4dddc7d-2837-415e-b8fc-c82fb469fb71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:Q9Y572"}
{"id":"69c1379e-b0e8-4d5f-880e-9ead171b25a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:6d035280-941d-442a-a071-1754110507bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P07948"}
{"id":"61980033-1cbf-4361-88c7-f47e52ad6953","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9844711","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:f8f8f25a-046e-4578-835f-7989ae251f99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:746","original_object":"UniProtKB:P23416"}
{"id":"0a628558-8e16-40b0-b6db-3c285fa480d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:e3915de6-f040-4c65-8f39-65070512d58d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P28335"}
{"id":"0c7c69a5-b906-4c03-8f77-994d53db5f90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16181638","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:24d63482-ccbb-4df1-827b-7c70d13b3db3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4161","original_object":"UniProtKB:Q12879"}
{"id":"647f6868-5b42-4443-8851-1bff3f67c458","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67116280","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:c7a80fe9-9674-486b-9d0e-5b64a3d1a170","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9308","original_object":"UniProtKB:O43613"}
{"id":"b46e7723-de6d-4334-915d-dd4461ce40d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70735","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:c8874e7a-70ef-49a5-b5fc-3cedec10310f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7461","original_object":"UniProtKB:P14842"}
{"id":"1a17a898-528d-48f8-8a8d-1f14509c1ffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73380","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:16f6e912-0bb8-4e8d-b259-e319a6a58d99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:247","original_object":"UniProtKB:Q62758"}
{"id":"0c3813e3-ac9b-4936-bf53-9e592e1c7f23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16467","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:79621320-c328-4797-b079-8aef48c7e6f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:721","original_object":"UniProtKB:Q5T6X5"}
{"id":"d13dc9d2-37a8-42c4-ab80-06248b8970b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232497","predicate":"biolink:affects","object":"NCBIGene:3760","sources":[{"id":"urn:uuid:1fcfe0de-fecd-4079-a7ec-5c233989fe2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7768","original_object":"UniProtKB:P48549"}
{"id":"0eb4030c-396f-4d60-b474-a68b2b3ff9fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8484","predicate":"biolink:affects","object":"NCBIGene:3817","sources":[{"id":"urn:uuid:b4d73e27-54d8-4461-b271-b59a23a0d15c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8484","original_object":"UniProtKB:P20151"}
{"id":"a40bdd0f-8c3a-4277-9364-bd833133b332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93085","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:2f9015cf-7ae0-4d29-9269-2946da3bc244","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1184","original_object":"UniProtKB:P30968"}
{"id":"1ed0cdd7-1e58-4d8d-9311-8642abf73395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:818","sources":[{"id":"urn:uuid:f447c6a6-fbd2-483c-af7a-f1d8d0592ec6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q13555"}
{"id":"3ee027f8-87eb-4477-bb27-9a18ee8d9929","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18026","predicate":"biolink:affects","object":"UniProtKB:P10608","sources":[{"id":"urn:uuid:08d56725-b7e4-4c2d-82f2-4008f804794b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9809","original_object":"UniProtKB:P10608"}
{"id":"e00d475c-16cd-46af-9e8f-7bd8b5caa732","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1115","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:cc578a3f-b56b-4adb-8796-00e1720a8811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1115","original_object":"UniProtKB:Q02644"}
{"id":"410330e1-06e7-4934-ad86-74969184d8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:5a264ce0-f89e-46f9-8797-7e360e72fcfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:O00222"}
{"id":"f984d371-8bd2-45ab-a157-3cc2155ed927","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:4c89653f-0247-4f38-b8f3-792cfa4ffc94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P41595"}
{"id":"c7c8d69c-6d58-44eb-8361-cac70bec6fa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10426487","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:57fd901f-510c-4d5e-85d5-8b696bafa907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:291","original_object":"UniProtKB:P08912"}
{"id":"1d080773-f481-47ef-b8d0-986719c249eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10810249","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:d0ee4060-971d-455c-8f87-100ab8bc7208","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1262","original_object":"UniProtKB:Q9Y5N1"}
{"id":"a5bda7d3-195a-445b-b7d5-83a050545dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8I16YLE4US","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:772dea1a-54e1-44c9-8b66-d510bd67b096","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:718","original_object":"UniProtKB:P41180"}
{"id":"0c2815a2-9690-4e25-bcb1-646577dc0fd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34603","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:e294dee1-f62e-42f4-bb3c-710f88e5f2c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4098","original_object":"UniProtKB:P35523"}
{"id":"43849008-091d-4326-afcb-30e3d08be956","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92621","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:6e91f04f-3050-4bcc-9f16-1fa9ebd92446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:547","original_object":"UniProtKB:P13945"}
{"id":"987905de-f4c7-4175-b22b-5d6270e9a815","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91541","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:1127a1e2-11e9-4f85-8ff7-9ad88a6e11fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:330","original_object":"UniProtKB:P08172"}
{"id":"0ce64d55-4ac2-41e1-8d5a-7a8208986149","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5441","predicate":"biolink:affects","object":"NCBIGene:3764","sources":[{"id":"urn:uuid:ec582c91-573f-4202-add3-2b4eea2f456b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2414","original_object":"UniProtKB:Q15842"}
{"id":"27a4cda5-5439-4a08-96d1-1d82f03a9982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:65020","predicate":"biolink:affects","object":"NCBIGene:4953","sources":[{"id":"urn:uuid:d1cd3b6f-3c90-4938-aca4-17a47369b655","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5139","original_object":"UniProtKB:P11926"}
{"id":"2b43379c-2385-46a2-b3f7-1da2f42ce519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15632","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:4c182c0d-700c-4376-9597-37c9d9f16e49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2483","original_object":"UniProtKB:O35433"}
{"id":"dcfe45a9-54ff-484b-8841-d1c767fe0d9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231667","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:55ddd986-06f7-486a-af90-c16dc904a1bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8072","original_object":"UniProtKB:P04049"}
{"id":"a9e53daa-872d-4b7d-8b19-a6fe776fa18d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9842556","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:92058de6-9f00-4ebd-84b0-cfbe320553f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6557","original_object":"UniProtKB:P27815"}
{"id":"110404fa-073a-46ff-81b5-0a7bcec6956e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:476f0bdd-5328-40e6-82ae-55218e331a54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:P22460"}
{"id":"0f926b33-9adb-4b7d-a1c5-ffe3f88a39b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50997674","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:b27dda21-8b96-4356-b306-cdcc6ffc90ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11806","original_object":"UniProtKB:P15056"}
{"id":"772f31ea-2ade-441b-8c4d-05a87fc48ebe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44309485","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:1532277f-bcb7-4486-b3b0-7d0e6c01efbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1740","original_object":"UniProtKB:P51582"}
{"id":"2da4bdb9-6936-407a-a3ae-c7e51b0f5048","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3842","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:af2151d2-c753-4934-b3b4-edbbb9807b41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3842","original_object":"UniProtKB:P41586"}
{"id":"4e7c7419-cc37-4cf2-91cf-87736f1ab335","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:fdae8f1e-0742-45e7-a2f0-9e9c0db5cd12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:P16388"}
{"id":"a138e8ed-ca28-4aa6-aebb-380ee8b9e931","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88219","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:8b41a788-768d-430c-909b-7744d3225fc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11134","original_object":"UniProtKB:Q5S007"}
{"id":"31d716e6-a4b9-4ed5-91c1-556512e5240c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2165350","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:efab966e-3261-47d0-8e3c-6b8ea63ca738","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11558","original_object":"UniProtKB:Q9UGC6"}
{"id":"9c530241-0256-4010-98f0-e5d1d7f18df0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73287","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:a9e18ba6-df44-48c6-89cd-40c7c2a80088","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:526","original_object":"UniProtKB:P18825"}
{"id":"7d127dbc-ac1a-4bfc-9664-49205584fc15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925850","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:0225ebc5-568d-401b-b267-5a0a4cca5c43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11565","original_object":"UniProtKB:P29597"}
{"id":"7259f689-e9ef-4660-8bbe-34348c712fed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:eba0b62f-ede4-4add-ab40-6b76f765b358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:O00329"}
{"id":"fb99eb85-84cc-453a-8fb8-2004d4961534","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15343","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:98326f45-fbb9-45e6-9444-ccb3e68a1af3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6277","original_object":"UniProtKB:Q8BLA8"}
{"id":"46e40c98-6f7d-443d-b25b-ae18a7951daf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98B425P30V","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:5ac9de06-57dc-4ab6-894c-9fd6ad8ec945","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:805","original_object":"UniProtKB:P51681"}
{"id":"c7d22d41-6cf5-452c-8075-42136fb93027","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4658","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:82007193-8fc0-4285-9b37-aa4d336c1510","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:68","original_object":"UniProtKB:P08908"}
{"id":"2982b344-d447-49eb-9ff9-d1a8e19b8109","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72296","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:940c0b90-f2bd-4703-8191-cf1e8d59c6c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6390","original_object":"UniProtKB:P00742"}
{"id":"ad55852e-6ef2-4b17-bf05-742d84bb26a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G6GSO9SDNJ","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:3f84f5b7-56cc-4f34-ab53-13a7a4d65dac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9852","original_object":"UniProtKB:Q08499"}
{"id":"f77b0e6c-6101-43be-99d8-9ce91710b128","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131438","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:32667a9c-547d-4979-b973-e44aa3afee17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1047","original_object":"UniProtKB:O88536"}
{"id":"5544262c-684f-4280-acbc-9710a14b0bc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67171","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:c0c7d5ed-baaf-4771-bf76-ae4c144d89d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9885","original_object":"UniProtKB:Q9BWU1"}
{"id":"abdd9a0a-5e40-4995-bb84-97452aa28fbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:530cd5ed-72e6-4399-9abd-af32cfe590fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:332","original_object":"UniProtKB:P08173"}
{"id":"8017a59b-0143-427f-bb33-863b7382bb08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44392511","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:4b7d3eb7-7a38-49b7-b4d1-d9130b9d60ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2994","original_object":"UniProtKB:P51639"}
{"id":"c28e5ecf-b6db-47d1-89cd-998ffb542664","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168510442","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:6a95e0a1-1805-4a8c-959f-df2704def77c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12905","original_object":"UniProtKB:P09874"}
{"id":"932c3d75-e8e9-4ae0-88cc-35aad18d6e03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817456","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:ba8deb3a-54c7-4c02-96b3-5ebf74d0ac06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6973","original_object":"UniProtKB:P30988"}
{"id":"41ba7f0b-2083-4593-a9db-8b042d7e754b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL85606","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:b22da7c4-670f-43e9-a55d-fda069bfb16e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:143","original_object":"UniProtKB:P41595"}
{"id":"b2e3cd8b-17a9-46d5-b68c-7e5307e81f77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:e1d6fc3a-d0e0-45c2-8bf1-8843a6ef9237","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P50750"}
{"id":"500843be-63b8-45f5-8d21-0b0623c0951e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:320fcc13-4e2f-4481-a866-caaccd5801b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:P51451"}
{"id":"4590afb5-ab73-460a-b425-090184c762ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:00c94ea6-8bf9-4c0e-800a-ecffeb057fbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P31423"}
{"id":"30bbb1f3-6fb2-4067-bd1c-45a4fd3a19d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:6bb4e723-4c3d-48ce-a48b-344c84c50f5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P43114"}
{"id":"61a26572-96d8-4701-8816-c411c970e5df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77961","predicate":"biolink:affects","object":"NCBIGene:53836","sources":[{"id":"urn:uuid:92ff209a-5c38-4526-b09c-b7e3c0772236","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2916","original_object":"UniProtKB:Q9BY21"}
{"id":"0bdff58c-2410-4bca-8c4f-97ce69199516","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173077","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:f6f29ed0-a178-420c-a49e-37718f5c93e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7875","original_object":"UniProtKB:P48736"}
{"id":"0ec809ad-7a07-49b8-9327-e5fc30b51fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44351001","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:477d9a7a-09d5-468a-bcba-9e3cbbbcae4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1507","original_object":"UniProtKB:Q63634"}
{"id":"af4bc298-057e-43a2-a0f0-9a4b1000ca02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9794656","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:57efd850-55b7-4194-bf66-e74ace3ca9dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:171","original_object":"UniProtKB:P28223"}
{"id":"6e14ac9b-867d-474f-a1a9-b321ca377a8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13809","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:050babf2-d018-4e1a-81ae-848b0285f60c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13809","original_object":"UniProtKB:P22607"}
{"id":"37e84107-1744-494f-8e35-e8861204db7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136046","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:d911ef5e-70a1-4bd9-9fc6-a90c33377a24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10423","original_object":"UniProtKB:O75116"}
{"id":"cb738168-67a9-4dec-a286-b67dd6923162","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1328","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:ffc18f89-38d8-4595-a532-179481a49249","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1328","original_object":"UniProtKB:Q01726"}
{"id":"47a514c4-d84c-4412-b127-778031a44fbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947089","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:353d44d8-e053-4140-91b3-c698c33f371c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2773","original_object":"UniProtKB:O75469"}
{"id":"b2ce1e4c-391e-4071-8a3d-447c5a24ec6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:924","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:bf9a6464-9956-422d-92d8-0ae9315307f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:924","original_object":"UniProtKB:Q13324"}
{"id":"9ed80c1e-adbd-47d7-8352-8908f93124e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z80293URPV","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:7d6ade44-33c4-42c6-8fff-6010ab5e865c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8709","original_object":"UniProtKB:Q99500"}
{"id":"b500869c-c63b-43d7-83af-b480b3149076","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:9a57fe45-4e29-475a-81eb-9f72b3c2fc87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:Q16445"}
{"id":"2c682f0b-e66a-4d87-8bd7-e209b48713b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:dd1e9342-a9db-433b-8a39-d7d12cfe38ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:Q9HCF6"}
{"id":"d0f65234-9411-44a1-a248-e3b1bf40ec72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92540","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:dfd481da-8650-4405-b820-94453abbc38b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5947","original_object":"UniProtKB:P06493"}
{"id":"387893f9-eaa2-4922-957b-0d0d68d2514d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:533bb7da-2838-456a-9b95-da710e571334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q9UKV0"}
{"id":"851cdf40-e3b4-4c81-852b-92f53ed3213b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118701008","predicate":"biolink:affects","object":"NCBIGene:9448","sources":[{"id":"urn:uuid:0daee62d-6ba0-4db3-b90f-93bef1a62d62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13265","original_object":"UniProtKB:O95819"}
{"id":"bc5eeb71-d5e5-4604-940f-5386d6019ac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1031","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:e11fc1ab-61f2-47e9-a091-c9f34caaef1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1031","original_object":"UniProtKB:P25090"}
{"id":"dbd584d4-5070-426a-9e2e-78a00e343774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:3769","sources":[{"id":"urn:uuid:c0b2a174-af12-4b43-8f92-18269218e566","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:O60928"}
{"id":"6a186538-8a7a-4b22-8dcb-96e809fbc2fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177793","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:ff1f5ac3-783b-4cd2-b4b7-193f515efc9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4048","original_object":"UniProtKB:P25116"}
{"id":"291b1f7b-5ad9-4941-82a7-4484187c85a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11617815","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:01537c8b-2fc4-43dc-bc38-8ed7bc41fc21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10586","original_object":"UniProtKB:P41597"}
{"id":"65a5a061-a235-482c-a656-360c2fb67a11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:325597","predicate":"biolink:affects","object":"NCBIGene:5696","sources":[{"id":"urn:uuid:14f26e9e-49aa-42b0-9df2-82e875128752","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8649","original_object":"UniProtKB:P28062"}
{"id":"6e484db8-34ba-4430-8691-d026f7e07798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8722","predicate":"biolink:affects","object":"NCBIGene:29480","sources":[{"id":"urn:uuid:ab4a82fa-e6ba-46b2-aa90-d5d1aed4fbcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8722","original_object":"UniProtKB:P49799"}
{"id":"841fc69b-e6ee-4ea0-8e1e-1568eb165b8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44316620","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:ab93624d-2cba-4ff0-90e0-8c8532c8fcd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:656","original_object":"UniProtKB:P46663"}
{"id":"a6f5f000-06ba-4020-be1c-3cc6a1c4dacb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:9024","sources":[{"id":"urn:uuid:5e0d94b2-b3a9-4088-ada7-364742ce3080","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:Q8IWQ3"}
{"id":"22358d9c-830d-4a08-a33d-ba5d8ca8bd47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34450","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:d9ee8b87-6a5f-4c98-a675-da9a8cb9fdd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6304","original_object":"UniProtKB:Q9EPK8"}
{"id":"a0a03628-15e7-4cfc-a08d-f6f0e386fe97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53394762","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:62d0a522-4a4a-46af-9d01-92851cdb2fd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11817","original_object":"UniProtKB:P97612"}
{"id":"ea6d3c92-e3cd-45e1-9bd3-ea0157c9063c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8207","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:59839dd9-1466-47bd-895b-742eca3ff0dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:305","original_object":"UniProtKB:P08172"}
{"id":"ae1dcfb6-6526-4a56-84e2-650a0896f186","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10111831","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:e34f7948-3b5f-44ba-a9af-d79c51a05a98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1942","original_object":"UniProtKB:P30557"}
{"id":"acf18858-c114-4dd6-a7cb-b6deaeeee4b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2008","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:d6ce340c-481c-4cdc-88a5-0129d82fe34d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2008","original_object":"UniProtKB:P31391"}
{"id":"192d16e8-a9a3-4798-bbe3-81363dfaddf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75261","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:2f1dd360-9d7a-44bc-9c00-bbf211f567ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2646","original_object":"UniProtKB:P13631"}
{"id":"67b72c61-5ce1-4b37-8cd5-09889d3c84f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28094","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:a1f01563-8c18-4da2-8d4b-d07c226ab4ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2293","original_object":"UniProtKB:P23979"}
{"id":"3ec4b2c8-db01-4dde-9772-96b8553ca0c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8B97A88D35","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:51ccf3d4-b220-4ea3-8915-edc69c5ec068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8915","original_object":"UniProtKB:O00329"}
{"id":"91a8fa06-4712-47f6-ba95-65db893fdb74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LGF3F89BZP","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:88dab14a-96c3-4d6a-b8ab-82cd2a7d2401","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4054","original_object":"UniProtKB:P10826"}
{"id":"9ba2d4e6-6cee-45ed-8949-e1207a1bcaf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:300cf7cd-4869-4f14-8cb9-702c9e13e8ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9NYV8"}
{"id":"7d6997ce-b164-43c9-87ad-93d9a5ef6c3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4023","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:4de90b34-dd1d-407d-a3df-abb86fb1dff6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4088","original_object":"UniProtKB:Q14957"}
{"id":"fdce6930-fc60-44b4-b264-e23b5842f48a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53364549","predicate":"biolink:affects","object":"NCBIGene:57406","sources":[{"id":"urn:uuid:225d933e-95ee-468d-8ed2-e9fab0d76e73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9480","original_object":"UniProtKB:Q9BV23"}
{"id":"5a656b0a-e4a7-4809-97b9-2946a58b0d48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433294","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:5090349d-092d-466c-9fe5-2c7705e3bba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12669","original_object":"UniProtKB:P22894"}
{"id":"fe83cf98-af84-4d26-84be-04e6fae7241a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22146595","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:9eeb7799-26ee-4cf6-a4f8-aabd40bf3782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:618","original_object":"UniProtKB:P30550"}
{"id":"dbb14c31-b172-4566-a753-904446e9ade3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:20169956","predicate":"biolink:affects","object":"NCBIGene:8324","sources":[{"id":"urn:uuid:2cf72259-2ff6-4426-b0e8-562979eac044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12916","original_object":"UniProtKB:O75084"}
{"id":"91d0e94d-a94d-4a58-b065-2b7281fc024a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101882819","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:2b495425-7843-4bd0-b119-60882986f15b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11235","original_object":"UniProtKB:Q9GZQ6"}
{"id":"bc1803bf-b5e4-4d58-85e1-a432b3ec415b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:71104b11-08f5-42fc-8338-50ec43ea1f57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P50406"}
{"id":"78878c87-8e79-4b0a-b779-51504e6d779f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44185","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:062c2631-e583-4f6f-82c9-c5a4e447ba1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4815","original_object":"UniProtKB:P00374"}
{"id":"c178b6e1-5869-4410-a44a-d3526337c4f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10046145","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:9a7bdd85-5563-46ff-b300-94fde856bd8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5610","original_object":"UniProtKB:P30543"}
{"id":"c443e136-34ab-46be-9212-74861eb606e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49858172","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:0d828ae3-c52c-4e67-9dbf-a10df2329cad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7804","original_object":"UniProtKB:P56817"}
{"id":"ef1c915e-ee0b-4d1f-9f39-9b07b311ca0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:57165","sources":[{"id":"urn:uuid:dc8abcea-aff6-41e9-8823-b27b38f5ca25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q5T442"}
{"id":"4462ce57-0eed-4a02-afc2-1b662828e855","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32374","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:d8c9f06d-245a-476a-a7ce-c38187f13658","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5787","original_object":"UniProtKB:Q8TDS4"}
{"id":"3d06bee1-099e-4aa7-8621-96a7657139be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4081","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:2075f8b0-296f-4c73-b62b-e2c14459aa75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:232","original_object":"UniProtKB:P41595"}
{"id":"9b51015c-376e-4934-ab2f-3c4836fb6965","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947064","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:afd77e05-6694-4dda-8246-ef1b6fba7175","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2913","original_object":"UniProtKB:Q9UBY5"}
{"id":"c36e947c-ca92-4c11-a2ce-eb4d019c65fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59548652","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:a506597d-7e2e-424c-a9b4-5b003202f716","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6428","original_object":"UniProtKB:P31424"}
{"id":"9bc55d6d-a191-455b-98b8-31cfa590fa3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10450926","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:856a9483-bd5c-4551-bd97-4ef3e4b4353c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9610","original_object":"UniProtKB:Q16539"}
{"id":"feb6486c-a150-4775-b55a-40641485045d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A7CGH459FN","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:49bf0416-d6bc-43f0-b8cb-91c2f955736f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12766","original_object":"UniProtKB:P31645"}
{"id":"7dfed9ed-8ed6-4812-a375-bfb7cce80923","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:05a6138e-b3c5-463a-9fce-980caa9ce9ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q62053"}
{"id":"5b2fd9b9-b0b4-4fd3-9c6c-d522bf286149","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:2042","sources":[{"id":"urn:uuid:9251a860-812b-4562-9ff2-78b998106d58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P29320"}
{"id":"c2f1183d-a6c2-45f1-bde3-a45c2f252750","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B5TRY67L51","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:698460ac-1df0-4cba-a4e0-ccddd8478a7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10166","original_object":"UniProtKB:Q8TDV5"}
{"id":"783db53e-2447-4700-812e-5442208b2479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78549","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:83e94858-d8e2-4416-886b-19d2a0a106e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:92","original_object":"UniProtKB:P28221"}
{"id":"bc70b1ce-39a1-4690-8f8a-90b5d479ac26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154653847","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:3179394d-c433-4fb5-8860-2af331c4209e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13419","original_object":"UniProtKB:Q8NBP7"}
{"id":"2cde00be-ecfc-4571-abcf-28771217a5ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135379","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:bb07e9cb-eb6c-4ac3-88b2-6a0bc0c236b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:84","original_object":"UniProtKB:P34969"}
{"id":"06a3ebb4-f750-4e1d-95c5-8334cf1611a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5700","predicate":"biolink:affects","object":"NCBIGene:1135","sources":[{"id":"urn:uuid:e0c0e99c-63ef-4a63-b410-5aa170a1d706","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3963","original_object":"UniProtKB:Q15822"}
{"id":"9d97fa64-e32a-45fd-b94b-a81439c75db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:35025716","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:b427facb-26b2-4f7b-88ed-b291c31ff55a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3351","original_object":"UniProtKB:Q15722"}
{"id":"56b18e19-be24-48b9-8342-79074d133d1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8066","predicate":"biolink:affects","object":"NCBIGene:79001","sources":[{"id":"urn:uuid:38f7608b-07b9-4b92-9539-17e6b1506d73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6838","original_object":"UniProtKB:Q9BQB6"}
{"id":"6d602f70-146a-4457-b62b-080482327b20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:e274937a-4adb-4fcb-b653-108e586d5920","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P47869"}
{"id":"88e8b1e0-f03f-4d1b-b5b9-63fd26b999b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229222","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:bcea625a-ef27-4d60-bbf7-85993e9278f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7709","original_object":"UniProtKB:P31749"}
{"id":"1819e1c9-80b1-4a3f-86a1-c2af65cafc90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B7I5G3Z7XR","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:f6414fa0-c4a2-41a9-a872-64746549c4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7973","original_object":"UniProtKB:P42345"}
{"id":"c12db29c-9a05-4895-bda6-4e12e1f36c25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:19401","sources":[{"id":"urn:uuid:49562552-34be-4ae6-928d-4d84bcd029e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5383","original_object":"UniProtKB:P11416"}
{"id":"16ecae39-2bc2-44d3-8f01-b79477d7fb2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V70CKN90GA","predicate":"biolink:affects","object":"NCBIGene:1889","sources":[{"id":"urn:uuid:a2219ca0-9e8d-48cc-bbff-0e180c294985","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6507","original_object":"UniProtKB:P42892"}
{"id":"0f039aee-9aec-4f1d-826b-35a1b8748580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZXM835LQ5E","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:c3864f41-3481-44b3-868f-7517e5883652","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7902","original_object":"UniProtKB:P31751"}
{"id":"9a67f234-c3f8-4f54-a8f2-ddd7fdb782c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K4KAC9XCCO","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:8a6fdcba-a193-4477-b829-0ee3a0ac97ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9853","original_object":"UniProtKB:P27815"}
{"id":"73aca133-1be8-45c8-a429-a0fb8e76ca3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130169","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:b84593e4-ed2f-4df5-bd8d-c08e32b34e7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:331","original_object":"UniProtKB:P08912"}
{"id":"4689f014-739a-4c4d-94be-96f7487121a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91832","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:d890bc0e-e94f-498c-ba36-cc68669a27ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3285","original_object":"UniProtKB:P0DMS8"}
{"id":"8b84fadf-9d6a-4c0b-9839-12744d90c749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11663047","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:615f2955-658d-424c-9865-fd12a0bc1ba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3501","original_object":"UniProtKB:Q9UKP6"}
{"id":"cb058b88-648e-4dbf-85c8-abbe0bac60e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:445455","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:0a6a3d0f-623a-430c-8e48-c15b754105b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2653","original_object":"UniProtKB:P13631"}
{"id":"6abf1992-eaa1-4020-b59a-8fa2a18ad9d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80656","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:3a377d71-bdf7-44ec-9b94-d2cc80221746","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2741","original_object":"UniProtKB:P18825"}
{"id":"2b10c1b2-0d9e-4724-a2cf-2222e22ec63c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56964346","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:0f7727c4-2496-4100-800e-5a9f9b35e017","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4293","original_object":"UniProtKB:Q13507"}
{"id":"da9a888d-bf0b-4757-b62d-264746acc1fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37537","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:5422fcbb-4e3e-4511-9363-c73160e92c81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2341","original_object":"UniProtKB:Q9Z258"}
{"id":"8d24453c-9110-4d5d-93ad-6d638414f48a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135907","predicate":"biolink:affects","object":"NCBIGene:14715","sources":[{"id":"urn:uuid:0bb12eee-6ff9-4a4d-82f4-7ff545982d6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3860","original_object":"UniProtKB:Q01776"}
{"id":"8eaee5df-a48a-4735-be48-f4db1337fb8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X4D0G881CN","predicate":"biolink:affects","object":"NCBIGene:71884","sources":[{"id":"urn:uuid:42e9c528-c71d-48ae-88ee-f236d495bf81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11617","original_object":"UniProtKB:Q9D7Q1"}
{"id":"71aada57-58a8-4c90-9375-297bbf0d631d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10810249","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:c6713885-ba33-42c1-8abf-64f58a6a2475","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1262","original_object":"UniProtKB:Q9QYN8"}
{"id":"819d4744-9c32-42bb-8ab0-58d73aa4d0b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3850","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:523a3e92-9586-410a-bf4d-989775788100","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3850","original_object":"UniProtKB:P25103"}
{"id":"a54ae3cf-3985-49f4-8a2f-7e8a908cdfa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42611190","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:f26caa39-6fd2-4cc6-b3de-236fdafb8ac4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5802","original_object":"UniProtKB:Q15391"}
{"id":"ddb95a1a-a7fb-4614-9acd-82fac872831e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24809764","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:e9d4a280-47a6-4cba-b782-3c48c80a789e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8191","original_object":"UniProtKB:P50750"}
{"id":"e260a05a-6394-4071-ab3f-0dd3b51b5e9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164861551","predicate":"biolink:affects","object":"NCBIGene:217826","sources":[{"id":"urn:uuid:ebed77e2-c0e9-49d7-897f-25a750c96baf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13373","original_object":"UniProtKB:Q8R1P5"}
{"id":"3172ee07-eb37-4573-bdb7-0e651c2a814b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25099817","predicate":"biolink:affects","object":"NCBIGene:259286","sources":[{"id":"urn:uuid:dc442252-8f62-449e-8802-a3005bbf1472","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9112","original_object":"UniProtKB:P59535"}
{"id":"998fcd1b-71b1-47a2-823b-6b95286a0e3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996518","predicate":"biolink:affects","object":"NCBIGene:5653","sources":[{"id":"urn:uuid:fa4a1160-5f89-4334-8726-ef0b0d70ada7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10576","original_object":"UniProtKB:Q92876"}
{"id":"536db6d8-697c-463e-a2f1-6e676c58ce75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:d4bb1e79-e77a-4269-acef-d1dedd2c5fb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P28335"}
{"id":"9d389b4d-cccd-4b57-b2c5-b0ff14c0c34e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2316","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:662f8779-15ae-40ff-a3b7-a1a4da96b0cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2316","original_object":"UniProtKB:Q9UGI6"}
{"id":"57060e52-e82b-41d7-80b4-ede96c3f3c01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28125","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:8fec47ea-fba8-4316-b897-d11baccdfdbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1051","original_object":"UniProtKB:Q6RI86"}
{"id":"95f67dbe-0494-465c-8c8f-00b9981f8f00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:4fb0c1f8-3eac-4c69-b3bb-e3a86ca4b260","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P25099"}
{"id":"a3559494-29af-43b8-a39a-2da52c38ac34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91820686","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:8dc1b645-b272-4376-931e-34d279b4d013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13950","original_object":"UniProtKB:P31639"}
{"id":"9a0b3f71-5bdb-49d4-8e07-3dd0ff867ed2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114187","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:99c010b8-eea4-4385-848e-8358785862e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9002","original_object":"UniProtKB:P34975"}
{"id":"62e955e4-ef26-4f76-92a2-64de2edde99c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1334","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:c9ca0921-6a62-4b2d-aeba-9d0fb29b71d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1334","original_object":"UniProtKB:P41968"}
{"id":"498851a1-a278-4047-a7ae-52f8b3663f68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25149519","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:bfb5bad9-7f3b-42b3-89ff-eaba21c22739","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1200","original_object":"UniProtKB:P25021"}
{"id":"37fbdba9-047b-459c-92ee-c9ebbf69ff73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:08988cb4-ba2b-46c4-a293-24213c10f0db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P30543"}
{"id":"fcf44f76-8085-4d21-8497-bb1aef7ec2db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:41023370","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:3512c193-26e8-4bd5-bea3-d0a0eb8f1fe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10294","original_object":"UniProtKB:Q9BXA5"}
{"id":"f5b3e388-fd1c-4828-bb4d-129024656a54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P0GVQ9A4S5","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:43dd5e4a-113e-4a6a-a1fa-9f256b8a8f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11518","original_object":"UniProtKB:Q15116"}
{"id":"c73bb4af-222d-4d56-9873-2a3c5179ff43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:29659","sources":[{"id":"urn:uuid:f70a181f-82df-4acf-95b4-f299af6ee371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P51577"}
{"id":"2fdb4a76-1d06-4838-89e1-9a8d133e37b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177453","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:056c6025-ab29-4ba0-ba0f-1b51f58d1788","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8362","original_object":"UniProtKB:P30968"}
{"id":"dc5def8d-009f-4ae3-95da-eebecd5c61c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125640","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:52b535cb-b77c-483b-b18b-6be1398f30c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:372","original_object":"UniProtKB:P25099"}
{"id":"2a9545fe-5afc-4865-8593-447b0c6fe98c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433294","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:3f47df86-089b-407a-987f-d966d8f67a5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12669","original_object":"UniProtKB:P45452"}
{"id":"6547b265-386a-4f45-adec-f6a67ef3e326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:439","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:97c1941a-6843-4145-9811-2e7f0510b9b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:439","original_object":"UniProtKB:P29275"}
{"id":"b56982a1-4e1a-45fe-ae83-564b3fc2ca55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:86203fc0-ca94-4f19-9de6-6cc77a6fbf31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P35346"}
{"id":"0d1a2f3a-596f-4e80-a74e-8e5671d92eef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL69234","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:cc720658-b904-4b51-aea9-0cb1f9db7cd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1725","original_object":"UniProtKB:Q15077"}
{"id":"ec707cb1-75c8-4d88-b617-8d36a2f640d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:aeb2ede4-5f29-4d3e-b1e4-e6aa8949fe95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:710","original_object":"UniProtKB:P35561"}
{"id":"9c4b7322-1e2b-43ff-98a8-51507d8dd26f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:25033","sources":[{"id":"urn:uuid:0638664c-741f-466d-8825-6512d4afb43c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P28646"}
{"id":"44ab0c79-fa13-46c5-9a69-ded5f6cc1e6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:6fb7f6b6-ee06-4e5e-9aef-0dd50107215f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:Q15858"}
{"id":"726d7077-e34a-4b94-8ffb-22ff79e2efd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6443223","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:bbc38c38-de0e-4d7d-91dc-126b82e5efff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3103","original_object":"UniProtKB:P37268"}
{"id":"c5d331a9-7686-4737-9cd5-dcc492527d60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91378","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:cf4851d5-dd04-4e5a-86af-d549dfa12131","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10095","original_object":"UniProtKB:Q00535"}
{"id":"6f36ac5f-ea16-4bbc-a897-7d5e62fa5a21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:d4dad0d5-c8ec-4b5c-987c-0ec5fa9f80a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P22607"}
{"id":"7e42bf7b-8de0-4059-a3d6-a44426618c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2068","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:6abc14d8-8569-4dbb-b068-9dd8a2235583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2068","original_object":"UniProtKB:P30935"}
{"id":"2cab7430-bac0-46e4-b938-97ba57f7747b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:fa8c45e3-b1dd-41ec-b9cf-3b503804e1f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P09619"}
{"id":"de9f1928-a25d-4e73-900b-02a860e0c54e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50693","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:d3ba501f-7b2f-4479-883a-dc5a52b9b1a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5225","original_object":"UniProtKB:Q14432"}
{"id":"221e5a55-c6f6-45d2-a9f4-9e14d0d77fb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:249982","predicate":"biolink:affects","object":"NCBIGene:779","sources":[{"id":"urn:uuid:a9524bba-f6eb-4f31-b816-496688d2a06a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2518","original_object":"UniProtKB:Q13698"}
{"id":"de25cdfd-3730-4a1f-839b-6988101de630","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:f270ab5a-555d-4e1e-88f9-47e3c33dbd21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P28222"}
{"id":"d808236f-eb9f-4e8b-840d-dbb269282f01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146025748","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:5a21146b-823e-44d4-bccf-e194b486b8ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11210","original_object":"UniProtKB:Q9NQS5"}
{"id":"60a79d30-a0d0-4654-aee9-461fbba74ec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143992","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:08a027c2-8f9f-4152-8353-37b106f53cbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1410","original_object":"UniProtKB:Q14833"}
{"id":"5833439c-2245-4848-ac37-bbbc5cac3440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31445","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:ba6dc67f-1713-4988-93ba-cee655ddca1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2445","original_object":"UniProtKB:O94759"}
{"id":"f14d22bb-3041-4a45-b296-0fa2e2283878","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f107510d-cd9b-4d26-be0d-6e56baadefd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P30542"}
{"id":"b7cc5db7-96e4-40a2-8157-d01e7363ee72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:312","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:01aa9d13-80d5-40c5-80c6-b82b23199912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:312","original_object":"UniProtKB:P08173"}
{"id":"3662a851-1454-4e56-a71b-12e02977c7a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:fb48ad87-97fd-414c-969a-c5313d8901d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P00519"}
{"id":"481dd19e-b9cb-42ec-a77f-d2a6a6ca6b83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817487","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:a1a15b01-476f-4b66-9b8e-78027b726d3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6130","original_object":"UniProtKB:O43603"}
{"id":"90eb5cff-78f6-4e24-99ab-0beca8feb0a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:39053f94-b5d3-40c3-b878-516df048a017","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P36888"}
{"id":"9bdf33b1-82ce-4bf8-8ac0-c9f1adf3f017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3823","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:7a7d045f-0f93-449a-bdac-4731b744f374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3823","original_object":"UniProtKB:P25116"}
{"id":"1790923c-95ab-4522-90fe-3744e1a54054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24784658","predicate":"biolink:affects","object":"NCBIGene:6309","sources":[{"id":"urn:uuid:66603b30-eadc-4307-85b2-aab6552932ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13567","original_object":"UniProtKB:O75845"}
{"id":"9ccfbfcf-5791-41c4-9bdb-c9f055f83861","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15647","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:888dd708-34d9-489b-820d-d45e36771fde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2487","original_object":"UniProtKB:Q15722"}
{"id":"2cfb6f6c-81f8-403c-85f7-cf0bec06c9a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90841","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:46c51b03-a1e4-4a17-ab26-1844829e0616","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1776","original_object":"UniProtKB:Q9H244"}
{"id":"e87edfa6-7525-4c3d-9778-7ea6d432fe6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118335773","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:cab60de4-3e89-4480-a904-1a00b250d6ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10887","original_object":"UniProtKB:P08253"}
{"id":"7395dc0d-203b-4d69-a8f4-8a09b5930c22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92418","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:83dbe2c7-a542-48df-9061-1e47e00d72d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:295","original_object":"UniProtKB:P11229"}
{"id":"37affeda-52af-47e5-8a80-e735c6593be4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:b08199a5-3b5b-4a9a-ac09-841ee68bf935","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P28223"}
{"id":"2b2ab000-07c0-4e82-864d-672b75e64a40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9N6RK0CBN","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:35b75545-d958-48d4-ba30-2852dca2cdde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11516","original_object":"UniProtKB:O60341"}
{"id":"174b7481-a532-4b15-b26f-0c184622948a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6967","predicate":"biolink:affects","object":"NCBIGene:4158","sources":[{"id":"urn:uuid:83f06b1a-3e6d-45a4-a9c7-fdc5896cae61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6967","original_object":"UniProtKB:Q01718"}
{"id":"32883059-f28a-4a2f-915f-cae96c725f64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232516","predicate":"biolink:affects","object":"NCBIGene:66026","sources":[{"id":"urn:uuid:8bcf3af6-0d70-42d3-9cbc-ebfbea48a20c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6465","original_object":"UniProtKB:Q9ERZ8"}
{"id":"0a434651-2d5c-4bdb-9465-5e87c2602c0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11410354","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:2680862f-64d9-43a7-a32b-8914b84c7024","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10589","original_object":"UniProtKB:P41180"}
{"id":"1e4baafe-d86c-4318-9e5d-d66dcca1440b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3962","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:3be571e9-4cb4-429d-830c-6aef2b8fc8c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7000","original_object":"UniProtKB:Q9HBA0"}
{"id":"4ebb2281-ee54-4da4-b306-538d8be79c23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2549","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:c3acbf31-6a98-4f9e-8022-f1c8a4f8bdab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2549","original_object":"UniProtKB:Q17ST2"}
{"id":"aaf5e27a-ea90-400c-956c-21af9890dcfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813893","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:a0a2e817-8e40-4c5a-9c4b-47db8b8327b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8329","original_object":"UniProtKB:Q8WXD0"}
{"id":"826551c3-88d0-49a4-a5b5-35e64c1e78da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3B974D670O","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:cc61de24-6ba3-4ed2-99a6-a6c06462b18a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8910","original_object":"UniProtKB:Q13464"}
{"id":"e8fd8185-8044-46d0-b8ca-2af910520ab0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:5508126a-33d9-495f-b04a-6073e16a90c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:Q92769"}
{"id":"da20f8b6-848c-4451-9905-31aa61da91f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5044","predicate":"biolink:affects","object":"NCBIGene:7097","sources":[{"id":"urn:uuid:35e776e2-f969-4896-befb-ad6beac85f6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5044","original_object":"UniProtKB:O60603"}
{"id":"9afd618f-22e9-4a80-b587-622746d1c29d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16135","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:fd609587-f37b-4cfc-85f4-46fd1dd5e2e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1060","original_object":"UniProtKB:O15552"}
{"id":"31bc2dbb-a8a0-4860-a5f6-503fe2364456","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3103","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:db13afb5-9083-40e8-baab-59a110c28271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2366","original_object":"UniProtKB:P23415"}
{"id":"1244445e-e21c-4caa-b256-3cc9f9538389","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:24QBD6H83I","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:3a62aae3-947c-4ced-ac57-f029e15b4979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7727","original_object":"UniProtKB:P00734"}
{"id":"5f261560-f7ee-41d9-997e-e147d7f90d24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1820","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:b48ef8f8-e172-4826-9b7b-27180fe361f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1820","original_object":"UniProtKB:P70555"}
{"id":"7b6f47e9-6609-45f0-8478-afc9e20d46fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1048","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:b8f69234-9a59-4226-a57e-85e2807c9417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1048","original_object":"UniProtKB:P33766"}
{"id":"f57f8aa6-02cf-4466-8ea0-f794835ac180","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9167","predicate":"biolink:affects","object":"NCBIGene:319239","sources":[{"id":"urn:uuid:a0384d3f-cbd1-4721-b2bb-fb40a93df38d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9167","original_object":"UniProtKB:Q8BZP8"}
{"id":"93a73019-6e3d-410f-815d-fc8ad2e8a223","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6619","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:45cbd286-dcbb-44e0-8498-d63349164b15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10346","original_object":"UniProtKB:Q9Y271"}
{"id":"de8529d7-65a0-4237-831c-43f2761c3fc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a44cb8a7-7191-4f80-8d8a-171dcabec757","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P14416"}
{"id":"f66b151e-4854-416d-bf7a-4bac8d1b1e83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RWL9H93ARB","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:b52f83f4-418d-4ecb-bfba-351536a9c088","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3301","original_object":"UniProtKB:P21917"}
{"id":"0d57a80b-fe87-4d10-8f48-883a97030417","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71364","predicate":"biolink:affects","object":"NCBIGene:25245","sources":[{"id":"urn:uuid:bc46da43-8988-466f-8005-1fb8ba9cbddb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:667","original_object":"UniProtKB:P25023"}
{"id":"c4e7a53d-64ff-4c41-b33f-c428a1c5b969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71696703","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:8831ecd5-c0a5-47ae-aa69-87be3d5b2602","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12070","original_object":"UniProtKB:O14965"}
{"id":"1ba7406c-6186-4bab-a84e-9b0037046976","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10001434","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:6cf2a337-243d-4ffa-996c-1989bf16e533","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4326","original_object":"UniProtKB:P47869"}
{"id":"f7fd67a0-8bdb-48c6-9347-904754a70c4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2BT4C47RUI","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:4db9b62c-7b8b-4435-ac3a-e12dba929328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8090","original_object":"UniProtKB:P00533"}
{"id":"88481dca-179c-4d1f-99d1-fb54549bc4ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124929","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:514fd4e9-d3b0-4a23-adf9-0b4956570d8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9377","original_object":"UniProtKB:P53779"}
{"id":"6d82137c-aa4c-4f25-86e4-5aef7ddbdb23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5066134","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:156dfba2-4234-4314-bd0e-0e7613361b7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6173","original_object":"UniProtKB:Q8TDS5"}
{"id":"d1b8844f-fc95-40b2-bff3-8cf29ed721ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:146219","predicate":"biolink:affects","object":"UniProtKB:O54898","sources":[{"id":"urn:uuid:c150fb26-6079-4ac3-ab81-379bd7e3eb6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2519","original_object":"UniProtKB:O54898"}
{"id":"810a74af-4acc-4ee4-8720-d54369350e55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QR88H79VX","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:21a8bac9-bda2-461f-bede-81e662dad885","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9600","original_object":"UniProtKB:P35968"}
{"id":"79ae3428-55a9-4a39-9ac6-9eccf7a67166","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156473463","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:613e934e-c1d1-47aa-88e0-f7d580439f90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13500","original_object":"UniProtKB:P04049"}
{"id":"3c123628-393a-46c2-bd5f-5dca5804c3ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:225865","sources":[{"id":"urn:uuid:403d381b-011a-4571-9be0-98624f3dded8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q91ZR5"}
{"id":"a437bf3c-a849-42df-9443-3a66d7d530d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9827261","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:ea7163a1-eea2-448d-ad11-700409169f05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2665","original_object":"UniProtKB:Q07869"}
{"id":"f58c7b48-eb0a-4851-99c3-29a5a7748d73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60151587","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:4de7ac40-9498-45d5-ae15-a37bdf11eb06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12579","original_object":"UniProtKB:P08588"}
{"id":"cd01dc87-d7c6-492f-9926-6970d41efdbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:31049b19-554c-44b2-bdb0-124af4599400","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2424","original_object":"UniProtKB:Q7Z2W7"}
{"id":"34958d4d-3882-42bd-9bb6-919f1a8b2236","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679534","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:81ae5efd-edfd-4134-80ce-2472504e1725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11839","original_object":"UniProtKB:P01116"}
{"id":"749ea7f2-4a0d-4511-97da-c3335ebcde1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9896","predicate":"biolink:affects","object":"NCBIGene:9340","sources":[{"id":"urn:uuid:84f508f4-61be-4b76-879a-787da642c1cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9896","original_object":"UniProtKB:O95838"}
{"id":"437277ad-0aed-4614-9c0e-6c41e2cd56e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2856","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:8900e75e-4f9a-48e4-924c-649ceff4277c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5955","original_object":"UniProtKB:P49841"}
{"id":"53162d05-907f-48a4-9439-be4fe81b942b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8238285OA","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:c08297e0-a460-48c2-95ea-81648b7eba39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9307","original_object":"UniProtKB:O43613"}
{"id":"ffd8a9be-06b1-4e86-8d7b-2b528e542687","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71766360","predicate":"biolink:affects","object":"NCBIGene:8569","sources":[{"id":"urn:uuid:c2ed8b7a-8a17-4745-80e7-5835a273e296","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12385","original_object":"UniProtKB:Q9BUB5"}
{"id":"f2f72227-d8cc-4f16-8e55-e9ebd23876f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6522","predicate":"biolink:affects","object":"NCBIGene:242093","sources":[{"id":"urn:uuid:05988bd0-c574-4cc6-84c1-55f9be6f2bb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6522","original_object":"UniProtKB:Q7TQP4"}
{"id":"8a8dadff-a390-4925-bc2a-a811dde58ade","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B4D3WPS7JY","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:6c1672cf-30b0-469e-935e-62dcc24a62bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12245","original_object":"UniProtKB:Q13546"}
{"id":"f9715bf2-2af3-4de1-860a-1dff59cfd6e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8467","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:f2c4cc5c-e628-4b77-8812-9936cce02456","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8467","original_object":"UniProtKB:Q9BXC0"}
{"id":"3e7ffe1b-8290-4ccf-9ba4-ccffba941a2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155587867","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:beba7de6-8fe0-48cf-8f1b-b5b00182a97d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11510","original_object":"UniProtKB:P09619"}
{"id":"7dd78ecc-2a1a-4173-b319-375ae4f265ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137113","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:dce9c30d-cc86-4a32-ae0b-6093dd686953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7511","original_object":"UniProtKB:O60885"}
{"id":"f3aba318-3633-44e1-a493-f8f92a0d264e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36706","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:9a46187d-1b66-4448-8b87-7fc67f4ac1a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5051","original_object":"UniProtKB:Q9NYK1"}
{"id":"626a237a-f41a-4254-afd3-acf814788e75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53323315","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:fce317cd-fce2-4185-b116-ca36a37eb76c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1583","original_object":"UniProtKB:P20789"}
{"id":"6be33c9e-8e75-494e-aafd-5e6c478dabbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5478838","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:0c660b66-9d57-468f-ab2b-5a6e9e37cd0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9091","original_object":"UniProtKB:P08473"}
{"id":"86d835e2-1142-4252-bda9-e941af392ff2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59059","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:42b6b61c-a2b7-4792-a310-1e4143428d9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6290","original_object":"UniProtKB:O75762"}
{"id":"31395699-35aa-40be-84e2-24b3891c3357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:0ad00bd5-a204-4b40-8c76-27bd19e68c42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"3d06f847-e839-4365-8baf-21afdf3f2201","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:1f1475f4-8db4-42f1-9c9c-e3ca4604e625","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P43252"}
{"id":"a6b249e1-0c06-455a-9883-41b8a4f66f96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OW44B6FA0Y","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:ad7e2c2f-1dd4-48aa-aa40-b12881c87b9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3504","original_object":"UniProtKB:P49146"}
{"id":"c0ecc52b-37b2-487d-898d-e76d65df05b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191043","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:5a549fb1-51b3-4d6c-be64-e367cffa95c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12753","original_object":"UniProtKB:P34972"}
{"id":"5fdc380a-90bc-431a-a244-522a8a317538","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6095","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:29615453-7b6b-4f08-a261-335f43804c75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6095","original_object":"UniProtKB:O88626"}
{"id":"2e1754aa-64c1-443f-9029-8a7046c9674f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15756","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:ba4bcef0-98c0-4ee8-8ea1-8c84ba21aaf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1055","original_object":"UniProtKB:O14842"}
{"id":"ecf6eae8-1fc7-4407-814a-659164c01a17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433321","predicate":"biolink:affects","object":"NCBIGene:284111","sources":[{"id":"urn:uuid:3f9dc8cc-dd8e-4a8e-9170-49b6d1a5be78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12852","original_object":"UniProtKB:Q86YT5"}
{"id":"ceb34845-8519-4450-b4ec-339967a32785","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946795","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:aa8efc9a-ba0d-4af7-8ed3-77888d064358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12596","original_object":"UniProtKB:P0DTC1"}
{"id":"68a83283-7014-472b-adff-45ca5383d298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134427646","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:04caa42c-952f-4e02-a96a-fead69dc9c75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13486","original_object":"UniProtKB:O00329"}
{"id":"b7d1f5ef-a21c-46c1-8bfc-1779585ca3aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5855","predicate":"biolink:affects","object":"NCBIGene:160728","sources":[{"id":"urn:uuid:9ec95272-a8d7-46cc-ab56-e53e16bf2113","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2713","original_object":"UniProtKB:Q8N695"}
{"id":"91dd88bc-bacf-4f91-b174-0cd3867d9232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16978","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:cbceaaee-20a7-4197-bdfb-c9a84728c2e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3354","original_object":"UniProtKB:Q13304"}
{"id":"9850af1b-a84c-4327-be05-c7b30bb8076e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4B93MGE4AL","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:ad4ea411-b0e0-4205-8ef4-006e802d60ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9786","original_object":"UniProtKB:P22607"}
{"id":"246601b8-3ad2-4bb9-921f-17a2528fcfd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28969","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:a14d7812-73c8-4446-b55d-ae55967879aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:141","original_object":"UniProtKB:P50406"}
{"id":"8b2fb7be-7005-49f3-a400-3b584dd18bcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10918703","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:aa955f9e-91c7-48ac-847d-8003abc9d67a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9006","original_object":"UniProtKB:P41145"}
{"id":"0ce2b278-150b-4da0-b68f-8263b61bc40b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17750928","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:53fd512b-9484-4746-a7b6-32c0784c9524","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4338","original_object":"UniProtKB:P13569"}
{"id":"99ef736f-5441-4b54-9904-0a85ae78f6a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2788","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:f360d4d4-6eb5-4753-becf-339b76a6e9f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7117","original_object":"UniProtKB:P18825"}
{"id":"be7b84f4-c698-4073-9973-4defbbaf1af3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9873836","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:c0284c39-9671-4bd3-9463-f85525d4dd50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:885","original_object":"UniProtKB:P30551"}
{"id":"7795439d-5980-426d-8cc2-0d2f99978c0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165437860","predicate":"biolink:affects","object":"NCBIGene:7398","sources":[{"id":"urn:uuid:93876128-d1c6-4ce9-84a2-079151e45105","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12224","original_object":"UniProtKB:O94782"}
{"id":"5eb5dbc2-8cd8-4f4d-a740-4ae3c7e098c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9874","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:854abd40-7d1f-4f32-a952-36dde5b5f62b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9874","original_object":"UniProtKB:Q9Y5N1"}
{"id":"58d65044-a836-44b1-8bd8-6226a04d9764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143992","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:33611307-3318-4acc-8e8e-1c0564764df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1410","original_object":"UniProtKB:Q14831"}
{"id":"e35d87ac-2d3f-46dd-a849-b159448aa97d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16496","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:691f02e3-ec99-4b5e-8dd3-4139cedc57da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2803","original_object":"UniProtKB:O75469"}
{"id":"86424655-798e-499c-ab06-8ab31debd80f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231393","predicate":"biolink:affects","object":"NCBIGene:5753","sources":[{"id":"urn:uuid:462248bd-2f29-4652-b255-dc131cebc0cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9051","original_object":"UniProtKB:Q13882"}
{"id":"49948eb0-dcd0-4013-9b52-1f29f1cf5045","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:252696","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:179065da-774e-4681-878d-4b65a9c02e7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:429","original_object":"UniProtKB:P0DMS8"}
{"id":"b16c07d9-69b6-4421-9a25-85d77f2e0ede","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16509","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:161cf0db-636f-4aac-8c69-80c4115616f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6307","original_object":"UniProtKB:O75762"}
{"id":"8e5d650d-20dc-46e8-b0ac-822d7addb958","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:d6253452-5d9a-46d6-a5ad-80658f4794ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P35348"}
{"id":"c84830ed-a578-43cb-a3b4-24012bfd7177","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123132213","predicate":"biolink:affects","object":"NCBIGene:8726","sources":[{"id":"urn:uuid:ad758a1c-fb45-4678-a7c4-f61f0aded74e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9525","original_object":"UniProtKB:O75530"}
{"id":"77c76dbb-10cb-4cae-82f6-3f908d6aebd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:3654","sources":[{"id":"urn:uuid:5037a3b5-48dd-4d6a-8fb5-e090681d9350","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:P51617"}
{"id":"54785951-952b-4e06-8b4e-70e1bd7ee4fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48390","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:d18f57fd-bb70-4294-b7ac-937b74b8b36b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3308","original_object":"UniProtKB:P31424"}
{"id":"e1acb3bd-c5f6-4ba3-9ec6-5f0cd6cae467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118866105","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:0c850c23-7d31-47f4-bafb-2b2179fbb3c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10520","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"4a8f6549-50be-4f4d-8b3d-bf88befdfc16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:72c2367d-a876-4663-823e-03e0cdf1b328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P28566"}
{"id":"7eeb482c-852d-46a4-8257-3f24c69d3b54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1272","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:690f0a75-83a5-47ee-8e02-bccb64c02e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1272","original_object":"UniProtKB:Q9H3N8"}
{"id":"606e4f4c-f17c-4893-9930-639c72cf1f96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2017","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:7bb64525-c5a8-42fa-96b0-82e29371da21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2017","original_object":"UniProtKB:P30875"}
{"id":"6feedddd-4ea5-4712-b432-3e07494326a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2049","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:b47467da-3ea8-42f4-9401-f6ad8de9dbc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2049","original_object":"UniProtKB:P30875"}
{"id":"22951286-b6e5-4955-a953-b3f8e612fab5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:758","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:d9d0cb68-d41d-4bc4-8602-eafab4f264b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:758","original_object":"UniProtKB:P51681"}
{"id":"19b7a856-cbde-4642-9bca-fb91084164c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3962","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:34399cd3-ac1f-49ff-b2c7-74564edaa73c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7000","original_object":"UniProtKB:Q09472"}
{"id":"467293df-260f-40d1-bc8d-69276972830d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138628908","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:4fa9141d-a226-46b7-8e55-aa5905cd167d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11888","original_object":"UniProtKB:P37023"}
{"id":"7c4f04b5-0097-48d0-86f5-719e9711e90e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57999583","predicate":"biolink:affects","object":"NCBIGene:3706","sources":[{"id":"urn:uuid:32e2b07f-230a-45e9-a4e4-f378ffbd1905","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9548","original_object":"UniProtKB:P23677"}
{"id":"2dad51ff-8d62-4b9a-97f9-e5397a04a73f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:808","predicate":"biolink:affects","object":"NCBIGene:1235","sources":[{"id":"urn:uuid:70eb49b7-7bc1-40b5-a793-cc69a26114bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:808","original_object":"UniProtKB:P51684"}
{"id":"f854b5cc-90e9-4572-969f-24e4852e70f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:daaac057-c1cf-402e-9f7f-30c2a6c4e9b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P08173"}
{"id":"db6c1132-0abc-4246-b47a-5497f689a426","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:939111","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:ee684c98-8b88-4d94-8f07-f8ec22001211","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8115","original_object":"UniProtKB:O00311"}
{"id":"fbf5c0f1-5c37-41eb-9494-fa770f85931a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17115","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:bc9627d6-89c8-4537-b52f-7c9941653b19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:726","original_object":"UniProtKB:Q5T6X5"}
{"id":"d3b3d75e-55ed-46cc-804b-5f75af756f66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183424","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:a24bb610-0bd7-4608-a19e-bf02313a3d8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5554","original_object":"UniProtKB:Q9Y2T6"}
{"id":"00f40871-41a1-4416-aa1b-d25b14a7480c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:855","predicate":"biolink:affects","object":"NCBIGene:10663","sources":[{"id":"urn:uuid:cfeee212-1ebd-4c88-b9f0-b42951c09e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:855","original_object":"UniProtKB:O00574"}
{"id":"e64e7c88-ddde-4c0d-b628-2159c4f845ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25124566","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:b94fdd68-b102-4800-bfa1-1d66d02a35ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5870","original_object":"UniProtKB:O08725"}
{"id":"16d36dd3-d235-4a26-87e1-0b575842788f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:05b292b7-54ee-4ea2-94d9-3340e33ce809","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P34995"}
{"id":"8c2f23f8-779b-43ce-ab2b-a73c6ece9723","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:862cdc8f-4868-4833-b954-9afcb3f4771c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P28223"}
{"id":"157c71ee-dffe-4620-8884-2ca15f418664","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34543","predicate":"biolink:affects","object":"UniProtKB:P48974","sources":[{"id":"urn:uuid:9f473397-2015-4de5-9bc7-94afb8140970","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2168","original_object":"UniProtKB:P48974"}
{"id":"9d7d9be7-f5ae-4c24-9f63-772e99e629e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15335","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:f2649d9d-99f7-4409-81f0-532fe15f532a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13776","original_object":"UniProtKB:P27338"}
{"id":"911749e4-5490-4bc8-9cf8-211ff2b77a06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HOU4I0G29C","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:346a61de-9454-4ad1-ad50-042d20440bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:887","original_object":"UniProtKB:P32239"}
{"id":"2678d698-6758-4748-9ccb-bfdae40d6b26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92585","predicate":"biolink:affects","object":"NCBIGene:27346","sources":[{"id":"urn:uuid:4adc1454-fef0-41ad-98e3-90dd52bcce7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6685","original_object":"UniProtKB:Q5BJF2"}
{"id":"453b9c49-5a49-454d-8896-8adaf38482b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2250","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:5197f30f-9554-4eea-b497-879a5d8a6d46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2250","original_object":"UniProtKB:P30559"}
{"id":"477f0161-0dea-4ca6-ac6c-ba6b65597596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:8df8b4b5-9db5-49ff-ae1a-33147d6cc640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:P42338"}
{"id":"58476db0-67a5-4c66-9ff8-3fef395463a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311232","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:bc1e82e7-57d3-4374-b64e-d927c3b0df95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5824","original_object":"UniProtKB:P32240"}
{"id":"dbf8e4e5-19ee-4981-a837-c03357271ab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4383","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:122877ab-ead3-42de-8ef4-145b6c8a313d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4383","original_object":"UniProtKB:Q9HBX8"}
{"id":"0180cbe5-1780-40bb-b718-62167193dcf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95048","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:f846194b-3d65-48fa-9d20-8e212233e4b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4055","original_object":"UniProtKB:P10826"}
{"id":"b8459712-4f9c-4877-ade0-530bd61ba7c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166076127","predicate":"biolink:affects","object":"NCBIGene:8644","sources":[{"id":"urn:uuid:14719495-1acb-4dd4-b357-450743eeafd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13894","original_object":"UniProtKB:P42330"}
{"id":"73f531c9-39b0-49ba-a2f7-7724b866d2b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:3e15e3cc-9212-414d-9cc6-3d2784aeb9e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P0DMS8"}
{"id":"e1ef4eb5-2310-42fe-ae73-56e812a335fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5425833","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:363643d6-7545-4aec-96a5-ee4ae1787e12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12354","original_object":"UniProtKB:P34913"}
{"id":"587fff20-cf75-418f-b6a8-26e5891204eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188757","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:2a2c25f1-d8b9-4eb7-8733-2f6ab708cc99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7909","original_object":"UniProtKB:O60674"}
{"id":"2ea5be9b-a8d1-4e54-9e42-38c62d4a3249","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183909","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:5d12e2be-4fbb-44cc-92e1-e54746b36fdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7525","original_object":"UniProtKB:O60885"}
{"id":"fbfa947a-0cad-45f5-8d20-a87001b52297","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:d4794608-8460-4ade-8182-02bf047c82a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:P37173"}
{"id":"46dcd604-4d03-4720-8065-dab270b41013","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1544","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:a8c7c767-d4b2-4c86-a81a-6f51c87f259f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1544","original_object":"UniProtKB:Q63634"}
{"id":"9defb62a-700f-41ed-824a-f61613761b2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6220","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:223ab835-28be-4357-bc9e-a6829be21159","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6220","original_object":"UniProtKB:Q14416"}
{"id":"f5d3ee78-71a0-44b1-b1bc-e779bc1b0639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:2057f5b8-56af-4357-98ed-ad7f0696844f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P08908"}
{"id":"5fa17e40-6af8-42d9-8b85-23f764a10ff7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9985","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:f566f8b7-7f61-48fd-8efd-72155d4dd383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:349","original_object":"UniProtKB:P11229"}
{"id":"848b3b65-49f0-40e5-8d24-59e907744e24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50742","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:e7ff9574-e51d-4590-adb1-db8c8228c311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2865","original_object":"UniProtKB:P10275"}
{"id":"25fa42fe-81d4-43a2-86b9-f6f98adad6fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:4c77450e-57ba-42a9-96e8-2ac7d0b76b2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1052","original_object":"UniProtKB:Q5NUL3"}
{"id":"416a32ba-ece9-4b6f-814b-0490f5559ad0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31448","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:a31eb9af-c15b-4910-8a8a-2d989b8eaefc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4167","original_object":"UniProtKB:P48058"}
{"id":"adb6dd8b-516d-4aa8-a450-763a0e2ea853","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42628843","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:92059229-c907-47b1-9783-28cdf7f7e9db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9815","original_object":"UniProtKB:P06239"}
{"id":"f49f314f-daa0-4056-8dde-90cedbeb5dd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:345657","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:4d677c32-0def-441c-bbc7-3b2f3fb2dd07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4203","original_object":"UniProtKB:Q9UHC3"}
{"id":"a2654fb0-5c18-4eae-acd5-26669d3a0d63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:249982","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:bd04f7a4-0c9b-431d-91ea-459a8a283f0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2518","original_object":"UniProtKB:Q01668"}
{"id":"ba70ce7a-793b-4a5f-9e02-c41f796ebe4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0W79NDQ608","predicate":"biolink:affects","object":"NCBIGene:2160","sources":[{"id":"urn:uuid:4d4bf6a5-2ab4-41f0-baee-4c9a1a8552b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11754","original_object":"UniProtKB:P03951"}
{"id":"47eefc61-2398-4ddd-9964-9bd828d50c17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177746","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:a01bb74a-361e-43bd-a91d-89c50df741fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7956","original_object":"UniProtKB:P08581"}
{"id":"e0a83cbc-d8bc-4adf-abf8-edf979474288","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10806465","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:8be77bd9-746e-44ea-8328-d026d1508f4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:396","original_object":"UniProtKB:P29274"}
{"id":"d07642cb-1a35-468d-8c7d-362b8cb7e412","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131165","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:0e15e8c6-ce67-4032-9e17-a9054289562c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7943","original_object":"UniProtKB:O14757"}
{"id":"3a0d465f-bdcf-44d3-8083-24baf4d37834","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:799fcfa2-9834-4228-9204-7b35aa336108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:Q06187"}
{"id":"69839851-bb30-4361-bd37-58f7cc00ca2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49799093","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:d1025f5c-609e-403a-b8b8-1a9cfb42a126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5761","original_object":"UniProtKB:Q16581"}
{"id":"7370de90-8878-470d-8aef-bcddd2c544fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:3622a81b-ec68-4afa-b271-58703affdded","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P11229"}
{"id":"e8cd41be-6a52-4825-941c-be5b63a5c3dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604042","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:963b754e-ee2d-4ce9-9e5e-d7eefbb9abfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:168","original_object":"UniProtKB:P41595"}
{"id":"c9e770a5-e626-4c9b-a1c5-84a36d960a18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76332060","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:298fd5dd-1e2b-4cc0-bb28-b9a3a7d5acf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8187","original_object":"UniProtKB:Q13546"}
{"id":"5a0579b1-9875-484c-b5a1-8fa51693e4f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123131802","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:5fcbba0d-b662-425c-9ea9-aea5ac9063f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10192","original_object":"UniProtKB:Q86WV6"}
{"id":"3a62df1d-db6e-42d7-b289-77a02d5d1969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5583","sources":[{"id":"urn:uuid:afb606c3-fcb8-4465-9032-e8abcedae2bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:P24723"}
{"id":"d9bcfe3f-b2af-4ef6-9371-bdd744fccd5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3964633","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:02de23b0-616f-4905-92ec-82638a138c4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1398","original_object":"UniProtKB:P31421"}
{"id":"87d5bc85-1708-45da-a7fa-d54ab50bb35d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:71164a91-edfc-4259-826b-859fb0a87c2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P35462"}
{"id":"440ed7b5-5dfb-47ea-b978-a5df310423eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CHL9B67L95","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:934f9374-a6f6-479b-bf45-8336e9df19b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9196","original_object":"UniProtKB:P00533"}
{"id":"2c1cc6a3-f7e7-44d1-9007-88301f87d3c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:26580","predicate":"biolink:affects","object":"NCBIGene:6579","sources":[{"id":"urn:uuid:7bdfcf50-62e2-4ec6-878c-fbe4aa24445b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4570","original_object":"UniProtKB:P46721"}
{"id":"3fbfd87d-1760-4aa5-b140-9946615ceb8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12517","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:3b15d58b-e77e-439b-b11f-a3cabf833d1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12517","original_object":"UniProtKB:Q8NBP7"}
{"id":"d6ac3a3d-a9bb-4c6f-9e75-357d652a9c8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:e1e5fa0e-c64e-4f75-a1ae-79a84760f08a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P28647"}
{"id":"5f1bb4c4-f87d-49ed-83f7-fa9805a25be4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155409732","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:f165d75e-61cb-4848-98f0-eac04f3a90fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12277","original_object":"UniProtKB:P06493"}
{"id":"98c8c186-231b-4f09-b2fa-f186e71e1717","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:3481f5f6-e33f-436c-801b-fcfe666e6a35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:P42681"}
{"id":"f60061db-328d-4faa-a61c-17c3c177ed4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10458325","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:67276098-7ea4-4db6-8dfe-f13f4d7ea419","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7944","original_object":"UniProtKB:P00533"}
{"id":"37d954fa-c144-4687-96a2-1d211f0adb70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91418","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:358f8189-cb9b-460d-b470-4fbc63d2bffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5679","original_object":"UniProtKB:P17948"}
{"id":"28a54a97-4b6e-4842-a379-cf963b98290b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081958","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:4fec805c-6558-4e04-a0fd-eac41e6412f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9845","original_object":"UniProtKB:P32240"}
{"id":"e1429c44-af28-44b4-b9f9-15e3fa54d0bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4868568","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:c63e1f56-2e60-426b-95a0-b9dcae8ee371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11746","original_object":"UniProtKB:O00311"}
{"id":"52774d10-fffb-47c0-81c8-13d7c0804229","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44410045","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:87c9060f-251f-4bfb-82ac-9952adb32547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6372","original_object":"UniProtKB:P31424"}
{"id":"f39a64b5-c285-44c9-aef5-07195a53c132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134990","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c0bb4ace-85c9-4ea2-a058-9e06ae8e9c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:198","original_object":"UniProtKB:P28335"}
{"id":"6d71b52b-cfff-4028-aecd-077d29b91e09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10001434","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:b9624fdf-c8b0-46b0-a132-f05d1edb0e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4326","original_object":"UniProtKB:P14867"}
{"id":"ab5ecd3f-8963-4910-b4fb-eb623a935262","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:72f25892-cbfa-4962-be93-7aca0484bc35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:P57789"}
{"id":"3e6fee25-0335-4ed0-9aef-140c17afc9b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817455","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:b736249a-f64c-43ee-b5c2-82b0dd8570e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3776","original_object":"UniProtKB:P30988"}
{"id":"7903a590-894e-41e5-9c7c-e31ba16894dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:bde0a45d-da15-4bc6-86b2-ed90ecc5aa4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P48169"}
{"id":"c1db712a-0d10-426d-8987-e8d7171548c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:8d94ca22-beb6-4bc1-87d9-b176fa49c56c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4193","original_object":"UniProtKB:P14867"}
{"id":"6464cd0e-b846-4535-a27b-06a7f1eebb24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24820144","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:cae1fc98-c1ba-48cb-834f-c33f43ac5f76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:158","original_object":"UniProtKB:P28223"}
{"id":"817864c1-edc6-4d0d-9bca-3206c7313bfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80308","predicate":"biolink:affects","object":"NCBIGene:21338","sources":[{"id":"urn:uuid:e518f688-db74-4e19-a1ac-e98862d132e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2098","original_object":"UniProtKB:P47937"}
{"id":"1c2dbb23-b3c2-47ba-8cdf-922ec465179e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4708","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:6f87a2a5-99ea-47be-8aca-403f7f1ffc65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7170","original_object":"UniProtKB:P35348"}
{"id":"737c8a20-4e63-43df-a8d3-b0dd88eb3fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2610","predicate":"biolink:affects","object":"NCBIGene:117018","sources":[{"id":"urn:uuid:2129a100-0403-438e-82c3-1ff14044a06c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2610","original_object":"UniProtKB:O08962"}
{"id":"96da2223-40cd-40fc-a06a-122f0d2f0bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:25323","sources":[{"id":"urn:uuid:e0eee510-7c99-4d59-953e-4eb43ae83c7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P28565"}
{"id":"4b949506-9f5c-4f68-9919-122eebf11d99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1815","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:49bcd723-eb80-4c84-8433-e4a62fa6d414","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1815","original_object":"UniProtKB:P70555"}
{"id":"0d785308-b6fd-4ff7-b101-162772318158","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167693","predicate":"biolink:affects","object":"NCBIGene:2145","sources":[{"id":"urn:uuid:c3a9eea1-9d05-47ea-b5ef-bafea9e893bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8240","original_object":"UniProtKB:Q92800"}
{"id":"25aae8f2-2360-4474-af94-e6e6fdd35fff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:aa325eb9-d65e-4f3e-b9e4-2a9e4beaa634","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P28222"}
{"id":"12da7793-c65a-49ae-99a5-747e38bd760a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ADD4H8T3K9","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:088a2dfc-1f85-4a40-a8a0-51743da40724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3183","original_object":"UniProtKB:P14324"}
{"id":"e4192559-025d-4f4c-bcab-7767b9e960f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:615","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:f1a26c8e-20e7-457b-a172-50f95148b323","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:615","original_object":"UniProtKB:P30550"}
{"id":"bb228695-3896-432c-8c3b-6eae609284d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:1ac22d08-4f18-45a6-8d3c-584fb6085ba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2401","original_object":"UniProtKB:P15387"}
{"id":"04bf46d2-acdd-422b-a768-6d7ab3358f9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:6b03b5f8-2e6d-4cab-a017-25a5bea824f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P25100"}
{"id":"d0f694da-1f96-4614-915b-f8e9e55f3d04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1809","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:69221d0d-bb36-446b-bdd5-74a33f2d9556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1809","original_object":"UniProtKB:Q03431"}
{"id":"48925a8d-b003-4dff-9a93-234e9b23fa36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5262","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:912f20b7-2f50-41e5-9cf7-1be50a259aac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:410","original_object":"UniProtKB:P25099"}
{"id":"162265c1-fb78-4a5e-9915-dfc60d8ae17d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15964","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:9ae14690-e25e-48a6-b988-99dac55f88cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12470","original_object":"UniProtKB:P59538"}
{"id":"3085dfa4-c8cc-46a3-919d-19ae2160573b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164718816","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:dbd2628c-7a13-4c12-ac64-2854db3de264","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13214","original_object":"UniProtKB:Q9UM73"}
{"id":"423b78fd-a677-4698-805e-9b4f770d6790","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"UniProtKB:Q9JIS7","sources":[{"id":"urn:uuid:6c697af2-38c3-49d4-baac-723e9071ff18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:Q9JIS7"}
{"id":"4e358469-077a-42d0-af86-f1fc9e4bf228","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QR88H79VX","predicate":"biolink:affects","object":"NCBIGene:7535","sources":[{"id":"urn:uuid:da2e69c3-8642-413f-a471-81f34c21f1ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9600","original_object":"UniProtKB:P43403"}
{"id":"d309dee0-fd11-4b75-8442-6014c4dea8cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94038","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:76caa540-55ff-4dc1-b6b4-f4785ef9a632","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:300","original_object":"UniProtKB:P08172"}
{"id":"88122e22-6008-497a-b4aa-451d0516c850","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16219545","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:6109304a-7ed8-455f-be5d-6ccfe5206d9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:337","original_object":"UniProtKB:P11229"}
{"id":"907e9838-f599-434a-aec1-3e0f1e4aa36f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:22ac8b46-1e76-408a-9095-47dc918f999c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:P30557"}
{"id":"25ff3a8b-8af8-4234-be2f-342278904261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90624","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:6b73c3c9-bfd6-426c-a30a-c0497df63a9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5709","original_object":"UniProtKB:P08581"}
{"id":"039c4348-3db6-40e3-a8d4-f9004fd872fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64055","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:08719c5d-d443-4086-b042-f9017d7464de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:109","original_object":"UniProtKB:P28223"}
{"id":"1d67c1f4-775b-44f4-bea2-321d96d658e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10426200","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:413e9663-81ac-4687-bf73-a9ac9e7c8915","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12403","original_object":"UniProtKB:Q16445"}
{"id":"dfe71ced-7498-4e37-8685-1e8d9df94bf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:81a18959-bd5b-412d-b01f-8f57d723579c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P18089"}
{"id":"853d787b-7101-4c47-a783-cd2109308245","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6917952","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:0e598d6a-d656-49cc-b967-67f226b19111","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2223","original_object":"UniProtKB:P37288"}
{"id":"4d8d2ddc-aea3-4255-a578-b5b888b88af4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:931L4X5WMM","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:12db11ea-1b07-4843-8b7f-129df60dce21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1226","original_object":"UniProtKB:P25021"}
{"id":"e3f2c683-7a74-41f9-bf8d-6e9761389ca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:230710","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:79cfb36b-2d3e-4a53-8945-2bc1507759b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4255","original_object":"UniProtKB:Q9UL62"}
{"id":"cd4b12b2-cce4-4ccc-ada3-a01bd1fc9735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:4b0cfbf5-0112-4098-b9a6-bfd350a84fc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:O88854"}
{"id":"a87af418-cd73-4a92-9e17-d58d2d021ffc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154680842","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:993a1cf6-4bee-48a3-9282-1730d54abf38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13742","original_object":"UniProtKB:P00533"}
{"id":"24372571-d34a-4a6a-918e-85a1767447ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL158588","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:ffc11945-e315-49b1-bbff-f75bab9ca763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3109","original_object":"UniProtKB:Q02769"}
{"id":"15bfea43-9ac1-4137-8d95-c766b10aa826","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155195529","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:14e6c7e8-ea0a-4bad-953c-69db2b254399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11747","original_object":"UniProtKB:P10721"}
{"id":"34d61718-ae24-42de-93b4-b387a62d9f66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3883","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:079f677d-00f1-48ad-adec-de30f93f9e27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3883","original_object":"UniProtKB:Q96RI0"}
{"id":"0f30d6cc-8200-4e8f-9da4-f5601e7b2a3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109895","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:f2f865f1-8a28-40af-b529-19ce8546b29e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8222","original_object":"UniProtKB:P14902"}
{"id":"e1940223-1fd9-4128-8bc9-b6fa605cc4fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZC6062V1O9","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:736bb134-42e2-4702-a961-6a2d427f1421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2640","original_object":"UniProtKB:P10826"}
{"id":"a66f9f57-cfb0-4f13-a5e1-4fc2658f5e9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230483","predicate":"biolink:affects","object":"NCBIGene:56341","sources":[{"id":"urn:uuid:ef876da2-7899-4745-91bc-bf380f415834","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8955","original_object":"UniProtKB:Q9NR22"}
{"id":"3246df26-1cc6-4d97-bae2-ee1ccea6e5a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4435596","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:9be7a40f-5a8a-41f9-980e-e9cf28d54243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12561","original_object":"UniProtKB:Q9H1D0"}
{"id":"509ade7a-da5b-40dd-b644-e7e982d4e992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:bfd66a87-1dad-4620-8d05-60ac45ba1fff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P31645"}
{"id":"e5437b39-0a06-40a9-b560-614bacffab0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:d318a466-a63a-4ab0-838c-d79603c06359","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28566"}
{"id":"770d60b1-7f7e-4689-bbbb-90fe98ef2bd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:fa802baf-1eb6-4b19-8049-4b297fd27fd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P30966"}
{"id":"a7d9c461-b610-4c4c-80db-c35c990d08d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DLM851L3RD","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:31df3725-a865-4939-ad22-4adcdeb9c38a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3316","original_object":"UniProtKB:P34972"}
{"id":"d9f534ac-40d6-4426-9213-97d9278c328e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:623","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:ec31c947-81db-4818-9df7-b1b3af3d8ce5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:623","original_object":"UniProtKB:P30550"}
{"id":"44ffa72f-47aa-440a-9325-bf1e7bb98f83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:4e14dd2b-72eb-4ee4-b319-43bdd41c3a9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:O15379"}
{"id":"5d7af743-d882-4826-95c6-31a31cd6b0cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24954989","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:524ff311-9a5a-4880-a665-7f0e15ce0f02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7774","original_object":"UniProtKB:P48039"}
{"id":"3d65ebba-75cc-4951-a220-52add45522fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:259232","sources":[{"id":"urn:uuid:62e83d7b-c3ea-453d-9878-fc848f4f9a52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q8IZF0"}
{"id":"8e97a77b-ade0-4206-a543-144ca12737da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:9b1c2ef1-82f4-4fd6-95c8-f604b7e51ace","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q9Y2T6"}
{"id":"9e56d6e6-d0e1-4c32-89dd-413a8a4d29e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2581","predicate":"biolink:affects","object":"NCBIGene:65180","sources":[{"id":"urn:uuid:5a106440-6d58-4264-8604-da26a5a01ee0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2581","original_object":"UniProtKB:Q63881"}
{"id":"882e51fa-39b0-4652-a994-dfd680a648c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310996","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:42eb91b1-cbd5-46cf-9e82-7e6227e28694","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1755","original_object":"UniProtKB:Q9H244"}
{"id":"b07d6dd6-82d5-43b2-9adf-20d23ad5b09b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1151","predicate":"biolink:affects","object":"NCBIGene:24953","sources":[{"id":"urn:uuid:eaa2e7d7-c59f-4a68-9583-dc70896aebdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1151","original_object":"UniProtKB:P30082"}
{"id":"467b3abd-af64-49c6-9f7c-bd2a9550d629","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:772","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:a9c536f5-52c7-400b-bfda-caf6e837b511","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:772","original_object":"UniProtKB:P51685"}
{"id":"3e4cd3b8-214b-413c-91d3-3834e929935b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57330559","predicate":"biolink:affects","object":"NCBIGene:84876","sources":[{"id":"urn:uuid:19fbb991-5aab-4462-af43-1eaea1b54375","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12713","original_object":"UniProtKB:Q96D31"}
{"id":"cb1b6131-e6ed-4e36-bb90-9aed35f06846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KL7B6D38VC","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:b4442a34-4030-4105-b0ef-828833354f3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12319","original_object":"UniProtKB:P78527"}
{"id":"f704353f-cd7a-4ba2-a437-1d49c6b92a02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2271","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:1740905f-8c51-44fa-941e-f6127ae379a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2271","original_object":"UniProtKB:P32241"}
{"id":"1b6f6ad6-2bce-4c04-9622-a35b1202a6be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9C8MNF7CA","predicate":"biolink:affects","object":"NCBIGene:13982","sources":[{"id":"urn:uuid:d5bc1628-fd64-4fd2-8a60-48219b8b12af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6700","original_object":"UniProtKB:P19785"}
{"id":"6c5fb5c1-b391-47f9-b76d-a972ad6da4b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4067175","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:e1654d98-b344-4787-bfc8-ebf303890378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4067","original_object":"UniProtKB:P24046"}
{"id":"5aa33cce-59d2-4bc4-b9f3-91f5ef648663","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:168543","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:3ca28d3d-696e-478a-aff0-be9d2136c1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1930","original_object":"UniProtKB:P32240"}
{"id":"b6b4cdda-c0a2-4c34-8b4d-da56c4eccea8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10981286","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:04461c2c-bc8e-4bf1-ac7a-e9a8d8a27bed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5599","original_object":"UniProtKB:P29275"}
{"id":"d301b304-d318-46ff-9ebb-b888b0ef59b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95060","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:aac03438-db55-49e0-bcb2-7e2faa3bd9a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7379","original_object":"UniProtKB:Q00535"}
{"id":"48dae6f7-d403-41a5-8f69-b8f2313a392f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9352","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:eb4df5ba-4a43-45a4-ba87-0e7f160bc39f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5425","original_object":"UniProtKB:P23219"}
{"id":"fa0bd1f6-1aa8-4ab1-a8c6-86004c980279","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3972752","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:c065c4bc-3274-44b9-b6cc-df95c52a033a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1415","original_object":"UniProtKB:Q14831"}
{"id":"07e87da2-93c1-4e26-8870-6685bca17894","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17200","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:52470778-846d-4bb0-9977-b01172fd094a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1784","original_object":"UniProtKB:Q15391"}
{"id":"41fce255-b25b-481d-992b-a2b91b593cb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34649","predicate":"biolink:affects","object":"NCBIGene:343450","sources":[{"id":"urn:uuid:c18e2299-2433-4d72-862d-346c364d174b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2507","original_object":"UniProtKB:Q6UVM3"}
{"id":"cce81cbb-a68b-432a-a09f-5d86e5fac982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:2268","sources":[{"id":"urn:uuid:bb66c5a0-35ed-4f16-95f9-fb4a35ad0643","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P09769"}
{"id":"dc546f41-d002-4816-90a6-5ee48eac706f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138377384","predicate":"biolink:affects","object":"NCBIGene:19766","sources":[{"id":"urn:uuid:b14d9d96-1399-4e75-8d4e-91a9439fed61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13107","original_object":"UniProtKB:Q60855"}
{"id":"107ccfdc-206e-43ef-b8df-552318ca80bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:b19bb395-f2e9-4928-808e-98682784f961","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P11802"}
{"id":"c3bc0c3d-0462-4688-8c6c-8703e5acbabd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:421465e3-15b1-4f47-8236-7e2c16943619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P08908"}
{"id":"d031d94e-acce-47df-9bc6-fbe9796048e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78425","predicate":"biolink:affects","object":"NCBIGene:25051","sources":[{"id":"urn:uuid:e71bc6ea-7e8d-449e-8bd0-acfb51de8c21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7386","original_object":"UniProtKB:P32301"}
{"id":"bebd69a0-104f-4399-8484-81d7d680eb41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:09ddc681-f016-4c82-8bc5-735313cbf506","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P31388"}
{"id":"d87fcd70-054b-4d3f-9ed6-3f3200982173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137465770","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:6c2b1d48-39ce-449b-a8ec-b5d5687e3c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13009","original_object":"UniProtKB:Q96P20"}
{"id":"1f91101a-50fe-4ce0-8b05-e3da7b5d8c7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L1F3R18W77","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:6a5dd978-e52e-4037-be7f-622255b7533e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8962","original_object":"UniProtKB:P00519"}
{"id":"c51784cf-72dd-4f44-9ef7-4d0484fd8909","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10276","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:43c7d163-50b0-4b0b-bc93-6f1c99bc9ee2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:271","original_object":"UniProtKB:P31388"}
{"id":"0ab47db5-7610-4032-8622-2b6261e0e444","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233295","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:47748842-ddda-4665-b76c-70e600f34d14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8054","original_object":"UniProtKB:Q5S007"}
{"id":"2c429725-a4f5-44d2-9e36-6f289e32384a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3758","sources":[{"id":"urn:uuid:5a36e7f2-b5ee-4bcb-8f2a-3bfff7604934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P48048"}
{"id":"40669ac1-d089-44c8-97d3-70296f45f588","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321150","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:d3852c18-7020-4895-a815-7664ed7cfd43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10112","original_object":"UniProtKB:Q92508"}
{"id":"96687b1f-b5c1-4775-8ede-6e85a844e220","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46229","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:ad02bce1-7588-4902-8ade-48ef9d81fdc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1783","original_object":"UniProtKB:Q15391"}
{"id":"9737b9db-40db-403c-a0cd-24c74b0a648b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6915","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:c14122a6-d875-425d-bb96-7b8a7bf7823b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6915","original_object":"UniProtKB:P30556"}
{"id":"8100302b-539b-4843-90d6-733c73a9970a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91488","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:64d527f9-cd67-4f66-a3d8-31ddbc3cbc6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12581","original_object":"UniProtKB:P08588"}
{"id":"bebc6647-3e29-48d0-9174-d9bdf40f6b2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91210","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:1959905c-fbad-4089-bbf7-4992c376d51d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11321","original_object":"UniProtKB:P28074"}
{"id":"c2175ddf-0476-4545-82e7-eab08cdb7dd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35003","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:c0827999-cae3-4b4c-9dbc-6845dcbe62ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4068","original_object":"UniProtKB:O15399"}
{"id":"21ca9410-5d8e-4927-b29d-c1883ce40599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023896","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:9a484430-819b-4c0a-a386-65a6c95b896c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3186","original_object":"UniProtKB:O95749"}
{"id":"bd2f25ee-ec32-4540-9904-2c9d8734a696","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53308119","predicate":"biolink:affects","object":"NCBIGene:22953","sources":[{"id":"urn:uuid:6da61383-f9d8-4cf4-9f16-3c1247e06dc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9539","original_object":"UniProtKB:Q9UBL9"}
{"id":"1b94114d-328a-4f2c-8961-3949fccd4401","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49848557","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:f1275361-77eb-4df9-bcda-0e3277b0dfb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9492","original_object":"UniProtKB:Q99500"}
{"id":"41335822-6782-4ef1-855b-5a88d2342eb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46190877","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:61ac3e56-b802-4d6a-bfe9-b47826301d13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6252","original_object":"UniProtKB:Q14416"}
{"id":"029aec6b-ce74-4571-90c3-a6e469ad9502","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439414","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:041248f2-ae1f-4ae7-8148-250014a9f7ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:867","original_object":"UniProtKB:P30551"}
{"id":"20824879-b9fd-4a26-9fe4-06f4f898623e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145371","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:33630b74-b238-47c8-b1f4-921455deda59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7921","original_object":"UniProtKB:Q02750"}
{"id":"95b4e1f9-8aac-43c0-8df9-d5b70ce44fa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"UniProtKB:Q01956","sources":[{"id":"urn:uuid:25f75d3d-2067-401c-a46e-0b72f47ef422","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q01956"}
{"id":"2075932d-d942-4e12-8011-477d63041ced","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15951636","predicate":"biolink:affects","object":"NCBIGene:2191","sources":[{"id":"urn:uuid:47759663-f95d-4dec-8dd7-51ff71ba7dc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9893","original_object":"UniProtKB:Q12884"}
{"id":"075b6970-7744-4d0a-b2d4-b2d85a098e4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126970681","predicate":"biolink:affects","object":"NCBIGene:22953","sources":[{"id":"urn:uuid:f922bd6b-68b9-4693-b8ff-8e8f9b33a589","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9546","original_object":"UniProtKB:Q9UBL9"}
{"id":"ad691ac0-f9cb-43d4-84e1-b84aa1d0440e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL118044","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:7e81493b-c13f-4bbb-b7e0-50bcb32104f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5729","original_object":"UniProtKB:P0DMS8"}
{"id":"0c6b2cb5-5107-469d-850b-d9ffc367a4c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:19511","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:f9d42887-3aa8-4eba-9855-3c729dd65f87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2910","original_object":"UniProtKB:Q8K424"}
{"id":"effcfd40-484d-4403-a22b-29082c8746a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3001","predicate":"biolink:affects","object":"NCBIGene:222487","sources":[{"id":"urn:uuid:4bb60b28-57e0-489c-95ac-c7db1f2eeb31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5894","original_object":"UniProtKB:Q86Y34"}
{"id":"bb70c4a5-8483-44fb-8f8b-66b274ddf31a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2P471X1Z11","predicate":"biolink:affects","object":"UniProtKB:P01854","sources":[{"id":"urn:uuid:1b892622-201e-4411-a7d7-f1880dcaaa7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6890","original_object":"UniProtKB:P01854"}
{"id":"77e64f31-6ce7-4e5c-b25b-26d00cdbcb4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5036","predicate":"biolink:affects","object":"NCBIGene:4883","sources":[{"id":"urn:uuid:536e3e1d-f0d8-415c-acaa-8987ac1a4e8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5036","original_object":"UniProtKB:P17342"}
{"id":"4655d68a-3f4b-458a-8aac-69e5cd1105d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:6e282295-1df8-436d-bf02-5c31744c9e75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P08172"}
{"id":"1ad3edb6-875a-4dd3-85ef-ab41ac600d45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6A901E312A","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:2229d869-5198-4d7f-93b5-6a50fe2e2945","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6883","original_object":"UniProtKB:P00533"}
{"id":"a2e730d5-06c4-4187-a4d3-3da58a193821","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5866327","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:9f70e257-2ca5-40e6-b33e-1a0040b5ee74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1416","original_object":"UniProtKB:Q13255"}
{"id":"1d331053-e66d-4f24-9f3c-e4613c81adff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:d5bb1ed0-576d-4427-8c35-405f82d808b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:Q96GD4"}
{"id":"7e4e6d7d-afd4-4be1-beb4-a81a3026ca9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3084","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:eb2149a4-5c81-4431-8d1a-78c915a58a74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:297","original_object":"UniProtKB:P11229"}
{"id":"0bb63172-cf99-43a6-b13c-f5fad0ed9d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3207","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:faa38cd0-a707-451c-818e-c67643a36e1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7434","original_object":"UniProtKB:P08235"}
{"id":"20f029cf-025c-4b1b-9fb1-430fa88524c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10100","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:4b42e426-c8fa-4d62-afeb-413a2c13ee94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3322","original_object":"UniProtKB:P37231"}
{"id":"3a8f53d0-5a64-4294-8632-693bbbdf2978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11948634","predicate":"biolink:affects","object":"NCBIGene:716","sources":[{"id":"urn:uuid:c66659a6-c561-4ae8-a90d-784d7fc94f31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8619","original_object":"UniProtKB:P09871"}
{"id":"311a63aa-2d8d-4cb9-be42-a378d2afeaa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53319290","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:031868df-0d08-4d70-9016-0f488c40d6ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4583","original_object":"UniProtKB:P30531"}
{"id":"72483a5c-355b-4131-a170-089a5e360551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13852","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:33276188-26bb-44f8-8206-1ad4cfda432b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13852","original_object":"UniProtKB:P05093"}
{"id":"df0af8b9-ef68-435f-afac-3e641a4ca4fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53318624","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:5e10d1bf-4709-43a9-a606-33d78f6c7575","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6400","original_object":"UniProtKB:P41594"}
{"id":"e8142666-89b8-414a-929b-b9fc43007695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:33e22158-f271-4e82-8faa-c4460e9e4a43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q9UQL6"}
{"id":"817efb78-178b-46b2-bc92-77b2fb176e1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121334520","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:7b5a8042-24a0-4411-8ad3-6f09ff683c06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10142","original_object":"UniProtKB:P42345"}
{"id":"3aee5858-90e3-467b-a17d-6eb12bf17d48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156297592","predicate":"biolink:affects","object":"NCBIGene:369","sources":[{"id":"urn:uuid:84800445-7a57-435c-99a3-546d05512910","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12095","original_object":"UniProtKB:P10398"}
{"id":"ea5f41b8-9e2e-4f43-9e31-405207ea4707","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13287","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:53f7d55a-a222-4410-8582-1f8b9883e847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13287","original_object":"UniProtKB:P21554"}
{"id":"3c76bd11-620a-4aba-97e1-07e9fafb490a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3804","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:9522371b-61da-43df-acc0-e061f38e4992","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3804","original_object":"UniProtKB:P32245"}
{"id":"75e5b337-92c5-4fee-a4ad-f9ae159d248a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135946","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:17f202a8-95ac-489b-8d0d-93e3ec8c23fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:864","original_object":"UniProtKB:P30551"}
{"id":"7dfff119-7c2e-4873-a87a-d739bebfbb47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125516","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:be3a4f96-2099-4331-9d72-e937747cf36f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1582","original_object":"UniProtKB:P30989"}
{"id":"79759207-b96e-4dd7-99c2-6c7236101d39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11361","predicate":"biolink:affects","object":"NCBIGene:4851","sources":[{"id":"urn:uuid:7374180b-4816-465c-83be-1c31b407f466","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11361","original_object":"UniProtKB:P46531"}
{"id":"867372f2-036e-42e2-90bb-2b7f8c316c12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91352","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:bef9e3a9-7356-4729-b817-693d1e6caf61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9389","original_object":"UniProtKB:P04049"}
{"id":"d9de837e-dbcb-4f05-84fa-ed1dc3cc378b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146672992","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:74f79a45-41a6-42f9-95e6-82feac879536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11107","original_object":"UniProtKB:P0C6U8"}
{"id":"7b1bdecc-b5fe-4905-accd-fa8851a5dab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11193842","predicate":"biolink:affects","object":"NCBIGene:29665","sources":[{"id":"urn:uuid:5e79ea98-92d6-444c-ac51-7ed6096395ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7722","original_object":"UniProtKB:Q64663"}
{"id":"1c15a3ed-65e9-4f69-8226-014cd3ab7063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6132","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:dc10f248-e4ab-4a17-bc11-809f1fb57ead","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6132","original_object":"UniProtKB:O08726"}
{"id":"d5c5a8e7-5deb-4be6-b5e0-97242dbd58c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53364540","predicate":"biolink:affects","object":"NCBIGene:221955","sources":[{"id":"urn:uuid:8a60af45-d1e5-4386-88e5-62da1864b52c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10245","original_object":"UniProtKB:Q8NCG7"}
{"id":"359033fe-5217-469b-9a46-966905219f0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7478","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:bb9fd767-7181-4f2c-a915-1acd8415b5e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:45","original_object":"UniProtKB:P08908"}
{"id":"3681b63e-14b5-4b86-b881-3b17b70a29b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17379334","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:c0665fc9-7c31-4855-bebc-15d7e48eb5e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9748","original_object":"UniProtKB:P41143"}
{"id":"24add794-5b32-4ac0-aab8-d31afa0e498f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9R2G075611","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:57cd8e48-cfad-49d1-a1d9-a94d2e8dd7a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8060","original_object":"UniProtKB:O14965"}
{"id":"d89bb7cc-b52b-4464-ac2c-6f223bd8decb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44468926","predicate":"biolink:affects","object":"NCBIGene:3816","sources":[{"id":"urn:uuid:5740f730-2ea0-45bd-933e-de6c233b88a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8489","original_object":"UniProtKB:P06870"}
{"id":"fae52d80-1b9e-401a-acd7-cae53a3ec526","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:fd5405ce-45e2-4626-8970-a6e0109a5e61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:Q60614"}
{"id":"020e88ee-8e4f-4bd6-964d-9ba30542f899","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57748689","predicate":"biolink:affects","object":"UniProtKB:P0DMV8","sources":[{"id":"urn:uuid:4c642664-643d-4d2e-9dc5-adff085e78ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13794","original_object":"UniProtKB:P0DMV8"}
{"id":"ab7526a8-8bba-4574-890d-9aae6248c296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134726","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:4ae0d4d7-a207-4337-a18c-31ed64813f85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5608","original_object":"UniProtKB:P29275"}
{"id":"56932e5a-2c84-4ef8-afa3-6d7d9bcf6763","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23786499","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:c3b409c1-e3e8-4c11-9cc9-618071449ee8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1194","original_object":"UniProtKB:Q9H3N8"}
{"id":"ab4f1dca-fb88-488e-97a0-728e08aa5ed5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72963936","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:fbe8484b-60d5-46b0-a985-ea06b4f0666e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11640","original_object":"UniProtKB:P0C6U8"}
{"id":"a4a4633e-046d-41f5-a1c0-b785fad9d443","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1797","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:89523729-0893-4654-afba-7c21f94a621c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1797","original_object":"UniProtKB:Q03431"}
{"id":"daa21fbf-00f3-4fbe-b170-77299201ff70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZW18DSD1H4","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:0b66aecf-5f8a-4ac9-afd8-d661acf5cd6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10431","original_object":"UniProtKB:Q99720"}
{"id":"160dbd97-f5ff-4634-afaf-8698ea74aed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131438","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:4aab43f8-c3ab-4426-bf1e-e7308b2a4fb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1047","original_object":"UniProtKB:P25089"}
{"id":"37446246-344a-4e27-9dd9-5157375b1a63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233330","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:d4e6c045-7cb1-4ec0-b0b9-4b0e6b461417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2335","original_object":"UniProtKB:Q92952"}
{"id":"392286b3-2bc7-48c1-aac7-5c83abd9636d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68584","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:41d2996f-d3ec-412d-9414-4d8a70946ac1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2601","original_object":"UniProtKB:P56696"}
{"id":"37d6ebfb-ccd1-4008-b422-431e8fec8568","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:81574","sources":[{"id":"urn:uuid:5796499b-9167-44a9-9cd8-f254ed34c79b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:P04774"}
{"id":"e8b3641a-7301-4c21-b86e-e7a1587c8b76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42724","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:bd0b6ac6-f3f1-4759-bc3a-6709aa7ff8be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2146","original_object":"UniProtKB:Q923Y8"}
{"id":"578095ef-c160-4b2e-b81b-781d3bfebd4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141046","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:2be30ea6-9b73-492f-a99f-77b346891464","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1926","original_object":"UniProtKB:P32240"}
{"id":"e349c17c-21d7-4a56-9345-29d5e29490f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135613","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:be82ee97-c2d5-4ab0-9d6a-cc5431a29854","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5596","original_object":"UniProtKB:P0DMS8"}
{"id":"05dc6844-8933-4960-b706-0186496268b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5720","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:5c899152-be4b-45cd-bd8a-985162d7862d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:324","original_object":"UniProtKB:P20309"}
{"id":"786b3fbf-ca95-4f10-af9c-a5ae340b5a64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868452","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:c65e4fc9-d39c-4753-92e7-e1ca217026bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:129","original_object":"UniProtKB:P41595"}
{"id":"06c2006c-ba15-43b8-952a-c442689911c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:577","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:122fef65-e38d-454c-8ab8-84f9f25ca47c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:577","original_object":"UniProtKB:P21730"}
{"id":"1d6e2cba-85ca-48e2-8ab8-057035f4e66c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755184","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:221ff7df-fb68-47b3-9b28-2ccb9ac5171a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6192","original_object":"UniProtKB:P32247"}
{"id":"a72b14dc-34ae-4a25-8752-4423cf049323","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5000","predicate":"biolink:affects","object":"NCBIGene:121278","sources":[{"id":"urn:uuid:1a29832f-27ca-4128-b903-beb1df5c951d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4613","original_object":"UniProtKB:Q8IWU9"}
{"id":"44fa0f9c-79d1-443c-8aac-02e992b5f9f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030530","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:12d405ca-87ec-4581-87d3-07a76b4bd853","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10481","original_object":"UniProtKB:Q16832"}
{"id":"b1ea7a25-94d7-4d04-a3a4-dfbfae9d4c8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16978","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:efbf04ed-c5f0-419c-b131-0a51e32c6960","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3354","original_object":"UniProtKB:Q9Y271"}
{"id":"06782a3b-230b-459c-a9e6-974e42300133","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UI1U1MYH09","predicate":"biolink:affects","object":"NCBIGene:7941","sources":[{"id":"urn:uuid:a5f78aa5-89f1-4c9b-8e00-460c8a9d4306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6696","original_object":"UniProtKB:Q13093"}
{"id":"694343e0-4f5a-4aca-80ca-9b1b20899076","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VNM956Y27V","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:023668f9-fdad-49fa-bd0b-3328e3713c8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10360","original_object":"UniProtKB:P04629"}
{"id":"b51c5260-373e-43ed-8ab9-bdf0342a0204","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:181391","predicate":"biolink:affects","object":"NCBIGene:10381","sources":[{"id":"urn:uuid:a95c0b24-503e-4904-b1a0-152c33422952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8854","original_object":"UniProtKB:Q13509"}
{"id":"568ca31f-11b5-4af5-b67a-0c4c8838e82f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142183","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:760eee23-fd12-41ea-8442-8eb79e5ee1a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:166","original_object":"UniProtKB:P28335"}
{"id":"4bacf54e-1bac-4693-a480-17dba598c8aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127045422","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:2b661635-ef84-4a02-bc32-10f7b6a60f1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11212","original_object":"UniProtKB:Q9NQS5"}
{"id":"b625eba8-4738-423c-b348-e7a96c1d43c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12322","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:651333c6-dfca-48dd-a9c3-f6ec8aca8423","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12322","original_object":"UniProtKB:P0DTC2"}
{"id":"5ae128a3-6b54-4f9f-aefb-25646ad4f8dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:3c809ddd-201c-4faa-a9e0-998c9bf5b554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P30935"}
{"id":"99e4b412-b221-4934-a2bc-2c51c637d3be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17574","predicate":"biolink:affects","object":"NCBIGene:2103","sources":[{"id":"urn:uuid:a0cc686a-0bde-467e-ad2b-80ebd80c4b3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2829","original_object":"UniProtKB:O95718"}
{"id":"1a0a5fb3-9c0c-4d08-ad43-1b3806688d3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11483496","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:53cfcf7c-28ae-400f-8df5-f1ceea7f3c6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1589","original_object":"UniProtKB:Q8TDS4"}
{"id":"5d2ee8c2-2641-438f-8f3e-176ce055433a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O9H5KY11SV","predicate":"biolink:affects","object":"NCBIGene:823","sources":[{"id":"urn:uuid:9ebe907d-168c-44d0-af6d-aff32de7994c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10883","original_object":"UniProtKB:P07384"}
{"id":"509219e3-c59f-41d6-ad59-73505802a69f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101096","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:4bc81061-9961-4be2-a29c-c12e81dd2546","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6814","original_object":"UniProtKB:O43570"}
{"id":"1f47c3b6-43f5-4d3c-82ec-54a67e4bcb2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:3753c0f0-42e4-4250-8e33-cdeb789948a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P35348"}
{"id":"da0b08b3-c5fe-40f0-996f-a13700304078","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SIS5BFO4WL","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:f142f056-7ccc-4428-82e8-5740169cd148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8427","original_object":"UniProtKB:P28223"}
{"id":"ae6efe2f-d19f-4bec-8c99-1c6273f55c0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228258","predicate":"biolink:affects","object":"NCBIGene:56950","sources":[{"id":"urn:uuid:97909a62-89c7-410c-9038-7418279dab4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8239","original_object":"UniProtKB:Q9NRG4"}
{"id":"8a9f3e55-19d0-408e-a348-bae72cee6fb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:128a414b-d794-4408-bc40-f016ecdfb873","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q9P0L9"}
{"id":"e6d00a18-7563-424d-b98a-0b55474d0c84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:6e1c0dff-f936-4131-895e-709f9072d690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P35462"}
{"id":"be9be99a-c29b-4050-892c-02277e0053f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:16515","sources":[{"id":"urn:uuid:09e1d0b8-69b5-4ea6-a942-8f27d15507ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P52187"}
{"id":"77bd34af-65ee-4d72-aaa0-ddd697809175","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52392","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:674df55a-486d-4570-a473-ba8614d1e1ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:729","original_object":"UniProtKB:P20272"}
{"id":"3c5f73a4-7518-44dd-8fc1-4cf0e03b6efb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:1a4ed8bc-53cc-418c-b99d-58723dfe2d1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P21802"}
{"id":"68eba566-8106-4dce-8342-d45dc2c4bef3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368933","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:a35a507c-431f-4aec-9c0e-325d923efc0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12171","original_object":"UniProtKB:O60674"}
{"id":"d519c2e7-f35e-448a-af42-13f095c553b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:822","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:5b8d4df4-9eaa-4c58-87fe-1ac0a4d0283a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:822","original_object":"UniProtKB:P25025"}
{"id":"4cbbccdd-facf-4882-a65e-611b40e48368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45I6OFJ8QH","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:f03425c2-86b7-4a26-8712-1e6e4821a92d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11325","original_object":"UniProtKB:P0DTC2"}
{"id":"7fc995de-41fc-4d26-9cc8-f91d9830bce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139347764","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:2837c19d-cb04-47e8-b528-293185b504f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13570","original_object":"UniProtKB:Q5XXA6"}
{"id":"f6c85729-0d86-450c-addb-cebad3f35aa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104872","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:3bf0bedc-6b0f-4aa2-b715-19ba4fd290da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5260","original_object":"UniProtKB:Q07343"}
{"id":"8556b150-94e0-44a2-927c-2f232c1e8d9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54733935","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:1a09355a-df2a-4588-98b1-0f2b7b1d55ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3156","original_object":"UniProtKB:P14324"}
{"id":"a020530e-1a19-44dc-be63-106e57ef0b3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:202bbedd-ac34-44b7-9e38-b673b819b153","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12497","original_object":"UniProtKB:P59534"}
{"id":"6f5f8335-2539-4233-b5cf-a532dbdfbdcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164554747","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:745261e5-30d6-40ee-b3fc-caf6f2c1fe2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13355","original_object":"UniProtKB:Q9NWZ3"}
{"id":"171a478d-c70d-46f6-bde2-2e3ab6162af3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73990","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:5bcfe2f9-5126-47d6-8f19-5808639cbb59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5112","original_object":"UniProtKB:Q8TDV5"}
{"id":"7b475b90-106c-432a-b4e1-7aaf16999ae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177398","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:3e7ecd3a-9641-479f-990c-cedecdbec2d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5605","original_object":"UniProtKB:P30543"}
{"id":"bc174411-bcf1-4361-8bb1-429108db2b4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2067","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:fa371dc2-321d-4125-a1e4-43c952d1e4c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2067","original_object":"UniProtKB:P30680"}
{"id":"4c2c5cb4-b52e-453e-8cd9-f0f987e8e7db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KF50235Q04","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:f383e3d3-0761-494c-b70d-3adec735606a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7346","original_object":"UniProtKB:P25021"}
{"id":"bb0d9f6b-71bd-4025-8f57-98456c1017df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5697","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:a3addcae-822b-4fbf-a2d4-20318a299250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:432","original_object":"UniProtKB:P29274"}
{"id":"762af88d-6fdd-41c6-aae6-9d16e0451bcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8416","predicate":"biolink:affects","object":"NCBIGene:29254","sources":[{"id":"urn:uuid:ebdf9b4b-a223-4452-9533-ecd4d5e7436a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13530","original_object":"UniProtKB:Q8R431"}
{"id":"26ebb955-48c3-42bd-b3a5-8a88d1f5d4ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755021","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:08314733-c4f2-4297-be66-5aa4b9cf8fec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1847","original_object":"UniProtKB:Q62035"}
{"id":"a8983696-5d31-4a42-97f9-c270ed8ede9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72165188","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:cbdbdb28-715f-491f-b8e8-049ec67c8c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12258","original_object":"UniProtKB:Q5XXA6"}
{"id":"d02bbb96-0b64-4f5f-8e26-ecc5ab8ae1a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6839","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:afb6c05c-0dc6-44f5-938d-de4dd723d577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:483","original_object":"UniProtKB:P25100"}
{"id":"2d535d56-391a-4f4f-98cc-c50bdbbbd357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52717","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:14f44300-6e8a-4165-9011-047199225de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6391","original_object":"UniProtKB:P28074"}
{"id":"7b45b9ae-8766-4a7b-82e2-1029055fcf91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34146","predicate":"biolink:affects","object":"NCBIGene:436440","sources":[{"id":"urn:uuid:0d237c37-fba5-4a81-9754-f8303e50a730","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5508","original_object":"UniProtKB:F8VQN3"}
{"id":"81c1fb80-527e-4885-8875-9704bee56155","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZRN7LZK9TQ","predicate":"biolink:affects","object":"NCBIGene:5138","sources":[{"id":"urn:uuid:7f99e425-610f-4830-872c-a6f1245b4a11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5147","original_object":"UniProtKB:O00408"}
{"id":"9f6eb527-b113-48b1-baaa-fec71c7c55f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30659","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:9def2db4-b67c-4133-8cfc-4c99ba14c09b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6951","original_object":"UniProtKB:P10828"}
{"id":"2f718d14-583a-42c7-a2d7-2a5aee401120","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2496","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:ea06e9d7-6f0f-43e0-8836-eb835eb0c7ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2496","original_object":"UniProtKB:Q9WTR1"}
{"id":"81733213-4003-420f-a129-8747f208be26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:576","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:9823c82a-482b-45d5-ac99-64d3c9aaa2de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:576","original_object":"UniProtKB:P21730"}
{"id":"2f362d44-93c1-4935-87a8-493ff2fc158f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1576","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:cbd3bb3a-506c-443a-bb2e-bf3da85a0616","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1576","original_object":"UniProtKB:P30989"}
{"id":"f8d5f89f-a1cd-4911-bc0c-8f230776a645","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368933","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:33b87417-7ba8-4aca-be1a-fc62872f4eae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12171","original_object":"UniProtKB:P23458"}
{"id":"dffefee0-5d55-4dbb-8f25-c09242055b1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10043679","predicate":"biolink:affects","object":"NCBIGene:2346","sources":[{"id":"urn:uuid:c5731027-0292-40a9-88b0-ac63fa196226","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8659","original_object":"UniProtKB:Q04609"}
{"id":"6a822332-e1ac-4645-8045-79544b77eee2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y64GQ0KC0A","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:ee77a764-6b0a-407a-9ffb-d12e220f8811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10612","original_object":"UniProtKB:P08069"}
{"id":"96947bb5-7542-45c2-8053-513dfa14a815","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:6b91feeb-3c06-4039-8bec-f3ace45f74a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:P35499"}
{"id":"7e0a50ab-8e44-421d-a227-dbfdcdb8c92a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:63d5fcb3-ba00-4664-ad4e-2ac05bd05feb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P35346"}
{"id":"3c3fe04b-9c28-4f12-8626-10cd4e17a522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:f03d75b1-036f-4c17-a4f1-79c592ac3ef0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:710","original_object":"UniProtKB:P41180"}
{"id":"a40d9985-d2f6-40cf-b3cd-19f5d5ff1050","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755252","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:3361e7e1-9824-4714-a086-052a43d8c477","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6984","original_object":"UniProtKB:Q9EQ31"}
{"id":"066a88c1-6db9-4409-849b-772878cb3a42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10353","predicate":"biolink:affects","object":"NCBIGene:160364","sources":[{"id":"urn:uuid:2f51ebcd-62f2-4b74-b0c2-6196488c8b56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10353","original_object":"UniProtKB:Q5QGZ9"}
{"id":"edd3f893-8a74-4051-b255-7c686aaf78d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130966","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:0b221cdf-eccb-4a26-8e55-8465f22198d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3877","original_object":"UniProtKB:P30968"}
{"id":"0db96c4c-0566-43b3-a172-46ef87f0f4e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4L6071XH2J","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:9868bb36-9ef4-47ed-9213-d6e8ddb59424","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8439","original_object":"UniProtKB:P21917"}
{"id":"5d4f17f0-c1db-4d56-9e01-673b9cb42822","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4250909","predicate":"biolink:affects","object":"NCBIGene:81672","sources":[{"id":"urn:uuid:f021b4a9-e35d-4259-a92b-76fbb684d6b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6218","original_object":"UniProtKB:P35400"}
{"id":"b386d5bf-3d53-4e66-9992-05e92a960ce8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177401","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:e1cc12e7-e15f-4892-b55c-37ec3c087612","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2886","original_object":"UniProtKB:P56719"}
{"id":"3892b5da-e93e-48dd-8808-1ed468d4e3b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WGA8E072GX","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:bdf60a6c-1327-4189-9ad4-246fd48867da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:41","original_object":"UniProtKB:P08908"}
{"id":"0e3ae52b-abf2-4017-ab82-3f7a4dd4449a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135151902","predicate":"biolink:affects","object":"NCBIGene:1583","sources":[{"id":"urn:uuid:9e43a382-04cb-4ebd-a7ba-90c0e09ffd69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13856","original_object":"UniProtKB:P05108"}
{"id":"26bdc541-e5f9-43d9-9273-83b332f3305d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6278000","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:bc78b05e-12f2-4c0d-ac57-89c133f71aef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1382","original_object":"UniProtKB:P31424"}
{"id":"f1c5dbaa-120c-459a-bf93-72aad5840fa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73294508","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:2f284f5c-8db8-4bc3-906e-d863b40bc18a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9742","original_object":"UniProtKB:Q9HC97"}
{"id":"4fec638e-80ae-44ef-9008-ec7276870f6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:79885","sources":[{"id":"urn:uuid:5d9113cd-272d-439b-b360-2721b7b3ca18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q96DB2"}
{"id":"968dea3a-7615-4452-aa5d-ebf3d7413c4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7686S50JAH","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:323d9a5f-0db2-40ea-abcc-95fdd638b34f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7443","original_object":"UniProtKB:P17252"}
{"id":"8f9391b2-519b-4287-b41e-f217d6d65279","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:30eb7e26-0366-44f4-93a8-fd0dbc5ad783","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:Q92769"}
{"id":"69bd1367-d29b-4d00-b4b6-760d4d954b06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11301655","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:a891483e-e4d7-4d59-81ec-bc41bce94bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8441","original_object":"UniProtKB:P21917"}
{"id":"88b06cbe-c1e6-4d27-89b1-a6ffe73db56e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8673","predicate":"biolink:affects","object":"NCBIGene:380701","sources":[{"id":"urn:uuid:66e97a8d-cc05-4312-9355-ae9528d199bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4800","original_object":"UniProtKB:Q3V050"}
{"id":"60072b15-c1a3-4a1c-910a-9ebb3de33746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1329","predicate":"biolink:affects","object":"NCBIGene:17202","sources":[{"id":"urn:uuid:4c0c5e94-01bf-49f4-aede-805f05aaf5b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1329","original_object":"UniProtKB:P56450"}
{"id":"7785e0d5-ca06-4e88-8901-a955f7b9a25a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153380106","predicate":"biolink:affects","object":"NCBIGene:11091","sources":[{"id":"urn:uuid:e6409d8e-82f3-413d-b18e-c182d537dcb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12000","original_object":"UniProtKB:P61964"}
{"id":"905ef5d6-aefe-4e11-b240-956926776b56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91714","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:ca3a7661-844e-499e-905a-50bf43cfb9d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:278","original_object":"UniProtKB:P31388"}
{"id":"7155f281-a0ad-4d20-a41d-e6dda304b4a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:f121f22f-0859-4339-a7d2-813e4847d076","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P48050"}
{"id":"e494148b-30eb-4ea7-b70c-d00d637919a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4I9OVB1G7D","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:f3672253-2545-4ccc-8b56-e6419fa5327e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1256","original_object":"UniProtKB:Q9Y5N1"}
{"id":"2f94a6d8-1159-4607-afaa-52e052183ed0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755246","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:08cab144-c38d-45a2-a08b-c354367bfbcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6909","original_object":"UniProtKB:P30556"}
{"id":"2ce1aef3-26d0-4e78-8842-3a6cb7741393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9873","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:bc8c9a34-0523-4eab-9be2-dc270f4e498d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9873","original_object":"UniProtKB:Q9Y5N1"}
{"id":"2ea3e86e-7d61-40e3-92ea-949ecca1a1b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:862","predicate":"biolink:affects","object":"NCBIGene:12425","sources":[{"id":"urn:uuid:9ef0bcde-3495-4bf1-8f8d-851511ad7cbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:862","original_object":"UniProtKB:O08786"}
{"id":"70cf63eb-d639-4e1f-af05-b0c6ddbc5259","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"UniProtKB:P57059","sources":[{"id":"urn:uuid:797bfb97-67de-40ff-9248-ef8cd5f5f702","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P57059"}
{"id":"d76d1e00-544c-410c-b249-d21a419fb718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90531","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:8fba6186-3dff-4523-894a-776f5d0ba547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7946","original_object":"UniProtKB:Q02156"}
{"id":"4d920fee-88fa-4483-aad2-f15e8dee8775","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11520239","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:25e10590-5c81-4709-95b8-ac771c84d89e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1313","original_object":"UniProtKB:Q99705"}
{"id":"4987c0a6-ccb5-4381-89ce-446ea8031ee8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:a25effde-f9cc-4838-98af-8ba37a58d4c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:Q04759"}
{"id":"f2a879d4-8b98-477f-ad65-b726bd1349cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91747","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:ba1691ba-36d9-4115-a8a7-11cf8460f47b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:944","original_object":"UniProtKB:P21918"}
{"id":"5cc5a583-3d28-4bea-8e06-33ac0ca40de2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125640","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:a1ecfc03-bae7-42de-a4df-d3bac29d19a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:372","original_object":"UniProtKB:P30543"}
{"id":"eaa717ac-c564-49de-8896-44bd349d16e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17431","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:15558ce8-e144-41cc-aea4-373de30413a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4127","original_object":"UniProtKB:Q9UHC3"}
{"id":"91e580f0-156c-4f82-abc1-c809cdc43a53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46557","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:d1ad72a9-ac9c-4602-b4ed-ad83db0585bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3177","original_object":"UniProtKB:P14324"}
{"id":"781eaca8-61e1-4b32-ba5b-77ee96e2c4ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17407","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:3e52b12e-e6e2-4dd4-a163-492f367e13f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3050","original_object":"UniProtKB:Q03426"}
{"id":"cbf6d8aa-1d6f-4753-a513-2a87cb7ee9b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947004","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:83a16fbf-b6bd-4d73-8970-d0b7de141fc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3135","original_object":"UniProtKB:Q02769"}
{"id":"1e2690cc-ae5a-48b9-9444-219308edcf0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53319290","predicate":"biolink:affects","object":"NCBIGene:6539","sources":[{"id":"urn:uuid:9b885477-dffb-4c80-b58f-390546ce8fb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4583","original_object":"UniProtKB:P48065"}
{"id":"af975059-001f-4d9c-891a-8e3607143261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:826","predicate":"biolink:affects","object":"NCBIGene:12765","sources":[{"id":"urn:uuid:04df8a51-43de-4310-bd8b-b9ea1ddc6fa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:826","original_object":"UniProtKB:P35343"}
{"id":"78d7be2d-219e-4eec-8365-f1f9cb34975e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73356","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:ef2f3040-70c3-416b-bf2b-97667b97c5b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1608","original_object":"UniProtKB:P41143"}
{"id":"2393fbe8-b268-4d45-afe3-6906d2bba355","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:193597","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:59bc9677-ce96-4dc9-a8e6-c98b6601b5af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10383","original_object":"UniProtKB:P01116"}
{"id":"e4a1e950-02e0-433d-8f91-340371c4d79d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2271","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:b5e805fe-01c0-4ce1-bd3e-fa38d36b6904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2271","original_object":"UniProtKB:P35000"}
{"id":"19adbfe5-5ddf-416f-a497-161f960e9a73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176499","predicate":"biolink:affects","object":"NCBIGene:2879","sources":[{"id":"urn:uuid:d6f1c109-f2cc-4f48-905e-18718ee3de17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12800","original_object":"UniProtKB:P36969"}
{"id":"3466dfd8-e249-4708-bcda-c98b3f417fb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QXA2220N3T","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ccdef893-5002-4c04-b2ff-8702abb45828","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9447","original_object":"UniProtKB:P0DMS8"}
{"id":"578ca521-912a-44c0-9b7b-d0868d3aa8a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17500","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:9d5d8bd7-5179-4218-864e-ad973f534cec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4351","original_object":"UniProtKB:P32249"}
{"id":"4adc26aa-e0ca-439b-bb06-a22b67dbd26b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42623951","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:7051988f-64f2-432e-a174-58a9e40bc931","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6653","original_object":"UniProtKB:P48736"}
{"id":"5a5bfb77-2a15-4c1f-a700-bd37589d5483","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:881640","predicate":"biolink:affects","object":"NCBIGene:353174","sources":[{"id":"urn:uuid:0f918acf-c734-420c-9126-1ae84a34d78d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12563","original_object":"UniProtKB:Q401N2"}
{"id":"f06ec31a-52a2-4af8-96a4-585fc90a079b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CXA4I8AH6A","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:2414890d-88c7-4c18-abe3-b2437b34b997","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11304","original_object":"UniProtKB:P29597"}
{"id":"24fd5e8c-e38f-4462-8587-ff5ae99b5936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156775102","predicate":"biolink:affects","object":"NCBIGene:676","sources":[{"id":"urn:uuid:df4757be-3494-44fb-9e50-0eb812176fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12143","original_object":"UniProtKB:Q58F21"}
{"id":"f2777c59-c216-42a4-8426-fe3d74933d92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:84694","sources":[{"id":"urn:uuid:04544ef2-6862-44a4-8523-162d6ec809d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q969M2"}
{"id":"b8bc9321-c3ac-4f37-8815-9a9ab54ac151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Z28M5SX0X","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:f30ecab6-cc82-4017-8365-779b4da53c89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10627","original_object":"UniProtKB:P42345"}
{"id":"b6ff0137-3097-41b5-afc7-a0d049637508","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2185","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:3933920e-6949-4061-a278-15e96adb06fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2185","original_object":"UniProtKB:P47901"}
{"id":"6025a188-3695-4fa9-98cb-0095ca8f502e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28130","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:224c02e3-9f96-4648-ad1e-5eb98b7212cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1876","original_object":"UniProtKB:Q13258"}
{"id":"1e36c00e-fd1d-454d-a388-510f04eb7d98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118308152","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:9b458652-bcfb-42f0-ac69-d0137d470d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12604","original_object":"UniProtKB:O43613"}
{"id":"5005aeda-ef6f-4eb8-a846-1add0e60b017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155586901","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:de97958e-180f-46bd-884f-c26db402ab8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11526","original_object":"UniProtKB:Q9UGN5"}
{"id":"ca557721-228d-45a9-b215-d03e0cd2afc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A6WX9391D8","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:cf197c0d-48c2-4f2a-bd21-9ebd755ca43b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6073","original_object":"UniProtKB:P21731"}
{"id":"e6f0897d-534f-4444-8947-0e123120f3a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:b5b6e8b9-4bad-4a05-80fe-24a43b043c5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:P07949"}
{"id":"d3767435-7547-4137-87c9-3bee1487c5e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11915","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:012f562d-a4c0-4d59-af97-0fec178757c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11915","original_object":"UniProtKB:Q8TDU9"}
{"id":"e95a3197-3052-419e-90b9-b8fdc673e24a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9168","predicate":"biolink:affects","object":"NCBIGene:2280","sources":[{"id":"urn:uuid:d1245bc1-3292-4649-b581-b1381905ab28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6031","original_object":"UniProtKB:P62942"}
{"id":"131341fd-41cc-43ed-af05-c1f6c035297a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25192022","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:852d0318-a3f5-48db-b3cb-adc5c93538d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6158","original_object":"UniProtKB:Q15722"}
{"id":"b7f9f6d7-0abe-4b3e-86f2-a079607962e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SA2ND7EHY4","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:a7506e67-acad-46a2-a349-757c27aff8fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8836","original_object":"UniProtKB:P06241"}
{"id":"03f97937-c19b-4057-98cc-38072c7df49b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44156964","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:5536c2ef-e98d-4c21-9c71-9b27cc257a8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5815","original_object":"UniProtKB:Q6W5P4"}
{"id":"2f6454f5-c318-4c18-a89e-bd41dd241deb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:170123","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:5e23b909-54f8-4d96-a412-0c5bd7db595f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2936","original_object":"UniProtKB:Q92633"}
{"id":"4056031b-7a98-439c-ad48-c5549446baa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73977920","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:a13d1bf8-afbf-4b99-8c74-0efa6da8c985","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5598","original_object":"UniProtKB:P0DMS8"}
{"id":"ea8a3121-1dcf-4a0d-8803-41618496abcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DE4G8X55F5","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:01e0eef5-57b9-4836-8263-2f4aedf00136","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9194","original_object":"UniProtKB:P35372"}
{"id":"34b7d839-a327-4470-988f-d8923a93d354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:b8e21c43-5323-4d8e-98fb-33785a7b6857","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:Q02763"}
{"id":"c8d4449a-0fa9-4049-a3b3-7b2e497fddd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1329","predicate":"biolink:affects","object":"NCBIGene:17203","sources":[{"id":"urn:uuid:b9645a39-3cab-4924-96d4-cb0f56d8d03d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1329","original_object":"UniProtKB:P41149"}
{"id":"eecdcff8-1151-47fe-baed-364c6119dee4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:e53bc71a-6640-4f40-bdc7-eda5e1d30216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P28223"}
{"id":"e243d9c4-fd56-43ba-99a5-b26982941bb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8931","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:cdc2c25a-5e71-4c31-9c34-f3865b0822d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8931","original_object":"UniProtKB:P21860"}
{"id":"de0667a3-4387-4c7e-acaf-0cd354cc8979","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71727668","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:6ff8e70b-c5da-47b4-a8e3-1f6de625644b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9803","original_object":"UniProtKB:P29597"}
{"id":"d3f9a255-b44e-4695-9018-9c6b1f7e48c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O609V24217","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:d53a2f4f-a9b4-42e1-8085-ab484879b6d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:980","original_object":"UniProtKB:P30729"}
{"id":"8e74a673-a2e2-4659-9af0-0bedfb6b16b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11498992","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:95e8a335-03a0-4b61-b74d-d8b6d687da7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3210","original_object":"UniProtKB:Q62967"}
{"id":"6976d779-b2a8-4998-9a7a-377414a6fcec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92566","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:1ea76698-e6ef-4d7b-9fd3-c641ce49c5f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:122","original_object":"UniProtKB:P30939"}
{"id":"b681a4e6-a34d-4b44-962c-f005391716c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91380","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:9771a609-6953-473a-b9be-284ef46de15b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11665","original_object":"UniProtKB:Q96GD4"}
{"id":"f064aed4-d721-493a-82d1-98795ea14720","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7RPW6SU9SC","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:613111c9-aedb-4520-bef3-102c1ad76c32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13184","original_object":"UniProtKB:Q96P20"}
{"id":"c1598301-e6a7-4db9-b2a1-8e605c634de5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129887154","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:6d1b90b4-3916-484e-99bb-fbd149146450","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2269","original_object":"UniProtKB:P32241"}
{"id":"06001beb-8598-44f4-b74c-beba5372106c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:78134","sources":[{"id":"urn:uuid:0ebbb594-6308-4943-b5b8-5ec3f56e192d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q8BLG2"}
{"id":"d00c8c9e-4c1f-4861-94ce-fd16749a7007","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:993","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:b91be552-776d-4bc0-9343-2a05d847856f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:993","original_object":"UniProtKB:P25101"}
{"id":"4a2033c4-6745-4744-9658-4c0f010450d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126481870","predicate":"biolink:affects","object":"NCBIGene:2145","sources":[{"id":"urn:uuid:50dcc193-999b-4de7-ac8f-e6699f86321f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12282","original_object":"UniProtKB:Q92800"}
{"id":"08c22915-e7b1-4082-9f12-f04e63c4866a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4160662","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:b19dce69-585d-4a80-956e-7afe1df40070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10063","original_object":"UniProtKB:P50613"}
{"id":"158cb1da-6c89-4d1c-b796-017c6faa0adc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030522","predicate":"biolink:affects","object":"NCBIGene:15486","sources":[{"id":"urn:uuid:3671ad81-68de-49c7-8749-0ba95f2fdb2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10438","original_object":"UniProtKB:P51658"}
{"id":"fc01c339-7796-410e-b9e3-245d809ecff0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813889","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:d2afc735-fd46-419c-84ac-f2847c7cd3f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5391","original_object":"UniProtKB:O43603"}
{"id":"f3e9dd83-474b-42bf-b0ec-f1dbe438033b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:9edb5d34-5433-4366-8cd9-5f39828e97aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P10980"}
{"id":"d9c45d91-df3b-43ee-811c-737345287b87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11983295","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:e4bbe596-8cae-46c0-9e6e-17794eec94d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5990","original_object":"UniProtKB:Q9NWZ3"}
{"id":"eee0b522-d184-4ef8-94ec-085c2029e002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54613196","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:ecc98282-91b4-47be-a922-9813064dede5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8602","original_object":"UniProtKB:P08246"}
{"id":"6ba80415-6be8-4d80-b6de-74bf9943e6bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133823","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:f76f0b1a-d6f8-4db6-8d8b-41203c3ecd5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3592","original_object":"UniProtKB:Q62805"}
{"id":"541d9678-3279-4ca5-9957-13ef4924261f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122119","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:e9bfa1ff-087b-4bc2-8f0b-a5a8c6433df6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:882","original_object":"UniProtKB:P30551"}
{"id":"971c0c69-3b63-4020-8f07-2afc478dc618","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:688","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:d0ad9373-5a2e-4725-b082-e7a9fc5ada55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:688","original_object":"UniProtKB:P30988"}
{"id":"2fa5ca7d-957b-413c-a5ab-252c43e62ad7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135211735","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:aa44ff75-3f09-4cbc-9c47-e0677f641689","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12378","original_object":"UniProtKB:Q9UM73"}
{"id":"1b69584a-8613-4f2d-bbde-fe6db7429cad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:f541be0c-eece-46be-9937-c18b91b27db2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:P36888"}
{"id":"bb479ba3-cdad-4e8a-9543-99dde24ebcbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49836405","predicate":"biolink:affects","object":"NCBIGene:50507","sources":[{"id":"urn:uuid:0ab43c33-640d-4c6a-b3fb-829a53260d9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9934","original_object":"UniProtKB:Q9NPH5"}
{"id":"70bb3a77-819d-4a77-9d5c-e6c6c6aba84c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16296","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:dc7d5c9e-05a9-477d-8692-684cde24d230","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5798","original_object":"UniProtKB:P49019"}
{"id":"a537ba7f-e353-4076-bb0b-392df51b8d79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZN0X0Q76F1","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:cba1db66-1749-4605-a617-8b0be5a4747d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5965","original_object":"UniProtKB:P04626"}
{"id":"2d06d95a-3ddf-4317-8559-1093492fe7d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GNWE7KJ995","predicate":"biolink:affects","object":"NCBIGene:716","sources":[{"id":"urn:uuid:d9dd5ea3-aadd-40a0-a830-29afe4a5bc6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9807","original_object":"UniProtKB:P09871"}
{"id":"0f95c6e1-d9c0-4cd8-8dd3-3cb6266bf3ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167495591","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:0cbdb23c-9064-4b1b-9a48-df97abfd1741","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13845","original_object":"UniProtKB:P00734"}
{"id":"46ccf492-a9b3-45c9-aafa-32c44d1b0f18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149636","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:75a64afd-e7f9-4a72-9043-c7a870c7ee93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:801","original_object":"UniProtKB:P51681"}
{"id":"78e41e81-24fb-44e6-a0e3-4da435d9dbac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7Y0IV7N95Q","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:24f9a054-2512-4fd7-b59b-a2ae4c7eee26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9925","original_object":"UniProtKB:P04049"}
{"id":"e23a18b7-5101-49aa-b2b7-2fe5acf9b983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185642","predicate":"biolink:affects","object":"NCBIGene:19214","sources":[{"id":"urn:uuid:191641ff-8e6b-45d6-a440-982c32e63c9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1897","original_object":"UniProtKB:P70263"}
{"id":"14fb0247-ba01-45f7-a483-299d52425ee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14827778","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:bd9682fd-285d-4598-af3f-77250e7672d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1195","original_object":"UniProtKB:P35367"}
{"id":"93c679e4-28ed-49a5-baf6-3472826d5151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358783","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:5e1302d5-9662-43e3-9755-f8007833491d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11989","original_object":"UniProtKB:Q9NR97"}
{"id":"8d2ff785-244a-4c34-9368-e9edd1f91cec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91351","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:2e87667b-b2cc-4f87-a15a-c75df3e00886","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8204","original_object":"UniProtKB:P31749"}
{"id":"35af5ebc-d04d-4c21-835f-200cbdb00896","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135847","predicate":"biolink:affects","object":"NCBIGene:4363","sources":[{"id":"urn:uuid:a7b97a5b-6c56-44e9-9955-79ee06bb0a80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11741","original_object":"UniProtKB:P33527"}
{"id":"98a2b363-e4d3-4780-a130-6816514de035","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C79B5A73C4","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:17a4314d-d1eb-4bd4-96f7-086c898bc361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12562","original_object":"UniProtKB:Q9H1D0"}
{"id":"467efdb4-9de9-4c5c-ae59-1252454da3af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847194","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:e1422ed7-cbcd-4bb4-9215-3692d78f234e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:16","original_object":"UniProtKB:P08908"}
{"id":"40a9ccc6-edb5-45cd-b9b7-78a9d8c977d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:5e03d8a1-085f-42b4-ac68-e7671c7d5aea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:Q92952"}
{"id":"d842690f-f111-4a94-a0b6-b2f9edbc45cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91615","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:8746ce5c-94cf-4731-a272-b23461d4715f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6080","original_object":"UniProtKB:P25105"}
{"id":"1f2a8001-6a5b-42e9-b949-e403a546016a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:64433a7e-b7f2-4e8b-b556-fde84d2598c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:P06493"}
{"id":"861f4918-ff8f-4b34-b90d-d7cceb061c98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:362","sources":[{"id":"urn:uuid:f6adf207-2e6f-423d-a70f-e0b587538e41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:P55064"}
{"id":"bb68e112-7280-48a4-a27c-371f72428f1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135761798","predicate":"biolink:affects","object":"NCBIGene:51347","sources":[{"id":"urn:uuid:08af20fd-929f-4e62-98a3-92e11e0be964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8218","original_object":"UniProtKB:Q9H2K8"}
{"id":"b0e77f8c-e7c0-4fb1-aa26-17d078f9aaf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2154","predicate":"biolink:affects","object":"NCBIGene:217369","sources":[{"id":"urn:uuid:e9287cae-f671-42e9-be49-39ad8a577ee0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2154","original_object":"UniProtKB:Q8VIH9"}
{"id":"92a63e2d-4c1a-426b-a16b-ad97d37f379b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2271","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:f97fb425-4868-4f93-b0e3-c4425d630e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2271","original_object":"UniProtKB:P41587"}
{"id":"4f1bc0bf-7e72-4d7c-8366-7efec467fd3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145430","predicate":"biolink:affects","object":"NCBIGene:3417","sources":[{"id":"urn:uuid:ad389623-0a82-4fc0-8cfc-63cd3199c1f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9217","original_object":"UniProtKB:O75874"}
{"id":"1ebcfdf6-f3de-4561-b92f-39212b6de16b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14372618","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:7adb4623-6500-495b-b56f-498dd272ed1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9878","original_object":"UniProtKB:P27815"}
{"id":"ee6ac7d3-78ec-4fa9-bbee-fc73f2dec86f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4GF4A623RF","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:b9cceaa3-f83a-47ae-a1be-da54267f04bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8051","original_object":"UniProtKB:P06493"}
{"id":"acfbe3c4-28d0-48f0-a90d-ffa75936879b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:1200dfd9-c1a2-4378-b489-e2f5e5325659","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P32305"}
{"id":"aca777b2-f1dc-4ddf-8f40-3898fb9f38a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:c2bd14a3-5f8d-402e-af51-870dfc8e6e87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P29274"}
{"id":"2a116f00-750c-4ff6-8810-5265a758dceb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49831044","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:3b650ffb-52bd-4223-8e95-413909cea393","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7700","original_object":"UniProtKB:Q16288"}
{"id":"ae4fb9af-435e-4935-8b6d-f33fb36afaca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8461","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:e780d5fa-772f-4468-ab17-8e8fe8e22f89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7282","original_object":"UniProtKB:P35367"}
{"id":"d33baec9-5e2c-4d1d-ba0b-bf8113aa3b63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:06A0IC74I3","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:7823e1b5-29db-4f90-beb4-2ede84592899","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11488","original_object":"UniProtKB:P13612"}
{"id":"98483e66-9dab-4eca-a505-2cab9fbba722","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:bb282f61-6b3f-47c8-a2e7-31d2cd43072b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:P12931"}
{"id":"6d97f8c2-bff2-4b02-b40f-9d2da5723eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:da3eaa76-49ee-4cb1-9195-590e5ee41871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P04629"}
{"id":"2ff52d07-8e09-4f1f-a2cf-48c8d2965ab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:13611","sources":[{"id":"urn:uuid:b09a2154-5dc5-4f7b-8d34-ed28f5c942c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:Q9Z0L1"}
{"id":"2c6e4902-7528-4752-b7dd-758600455854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A5595LHJ2L","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:de2799c2-ebfa-4fdf-a8aa-54ae05f45ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12644","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"2f42862d-8955-4f46-bcdb-d72053bd0f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2056","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:e2178fcc-3934-42a6-9d86-b00ea653e22b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2056","original_object":"UniProtKB:P35346"}
{"id":"936baf1e-8337-4724-b926-016453e54742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9887077","predicate":"biolink:affects","object":"NCBIGene:18389","sources":[{"id":"urn:uuid:308d871a-c8f2-4ea7-989c-cc59b9bc0222","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8868","original_object":"UniProtKB:P35377"}
{"id":"8f8794a9-07dd-4528-ba9f-e27e569437d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6682","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:cda0a968-8fc2-48c0-85f3-5156de26840a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13843","original_object":"UniProtKB:P15121"}
{"id":"48b67af2-f109-4efc-8709-f43540ae5ca3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124930","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:6bb8ceda-2f5b-444a-908d-fea87d30209a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8062","original_object":"UniProtKB:Q14164"}
{"id":"952d2d74-a74a-48db-830f-9c57b251eb9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:42EK42WHI5","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:47f06035-6d4d-4034-956a-01a3a4838d78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9620","original_object":"UniProtKB:P49760"}
{"id":"d3a2d09f-53a6-4a24-8cda-39872fc3bd31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28077","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:b2babab4-45f8-4f91-92d9-d7db73e89f71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2765","original_object":"UniProtKB:O75469"}
{"id":"0b2c3262-fe71-4424-b9fc-18d0b9d628c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:82549899","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:7e8a2597-01d9-4c13-9ec2-b18131e8670b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10554","original_object":"UniProtKB:O15554"}
{"id":"7cdc937c-6f83-4481-96d6-68f55c6fc3a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2576","predicate":"biolink:affects","object":"UniProtKB:Q63099","sources":[{"id":"urn:uuid:a343eeb6-b6e8-40fc-83cc-b5f702f1b997","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2576","original_object":"UniProtKB:Q63099"}
{"id":"b0762042-72df-447b-a085-a8d5ae857172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2214","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:90cb6b01-eda8-4f94-9dd7-1169d78d7a70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2214","original_object":"UniProtKB:P30518"}
{"id":"975d2e44-4e68-4b17-8f50-5dce69e1147c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:4365e0ff-d313-4cb8-bcfd-366eaa1bd243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P25100"}
{"id":"faa11341-4ecb-4e43-bb23-fcc6e08f31f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92733","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:5ba1bd6a-bd19-40d0-b625-399960bb7c44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1703","original_object":"UniProtKB:O43614"}
{"id":"eb7e3f94-fb52-429f-b3d7-39866cf0c1de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A07663A39I","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:d68892b9-d273-47de-aaae-582977a0763f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2755","original_object":"UniProtKB:P55055"}
{"id":"b0f73102-1308-4fec-bcc1-2b134b6a0ce2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2105","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:19bdaf38-413b-4f93-8f4e-36f28ead33e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2105","original_object":"UniProtKB:P25103"}
{"id":"e13d5d97-6464-4c3d-a65e-c1140a634421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:814","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:bc53b82f-ec2d-46e8-911e-933865c494c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:814","original_object":"UniProtKB:P51685"}
{"id":"5333a5d9-ecbb-4de4-b191-f3fc92e33e63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:8531e988-c72b-4bb9-9d26-f05b2bd7c915","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q8BLA8"}
{"id":"158d786f-0093-445d-8bd3-9a41e16c079b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:196a1ef5-4c02-47e1-a7a2-87b2e845b07c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P28335"}
{"id":"92b3a09f-baa9-452f-aad3-a76af5baa99d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925848","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:1fd63ca6-1d6b-4d69-bbbb-862c0123703f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11548","original_object":"UniProtKB:P49841"}
{"id":"dceef4d6-fa9f-4817-a7fb-885e547a1d3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996521","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:9dc24bbd-81b0-4748-9177-63e52f2ad9ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10582","original_object":"UniProtKB:Q9Y271"}
{"id":"ce22be4d-6133-47a9-b22d-a3a618392cf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438402","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:d766f1b0-40d3-4de8-a370-c6088b93d352","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1944","original_object":"UniProtKB:P32240"}
{"id":"ee8ff226-57a8-47b1-9a1d-1e93760ffef1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0I579CNG0I","predicate":"biolink:affects","object":"NCBIGene:81033","sources":[{"id":"urn:uuid:1c4aa317-e287-4dac-a953-ae061ef6266f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2308","original_object":"UniProtKB:Q9H252"}
{"id":"2f85d34e-77d6-4fd2-9913-f22627f6dcbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10254","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:9f1b4873-1243-4159-9280-8c6524db1434","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10254","original_object":"UniProtKB:P46663"}
{"id":"cdacc7af-1904-4161-b50d-2b8998d53b94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58961","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:8cd71992-7371-4dd3-9c83-1ebf3a543572","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3635","original_object":"UniProtKB:Q14330"}
{"id":"787d9b7b-5a4d-4cba-b351-07aeb426ec5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229800","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:490774c5-9ef1-43e9-85f2-de377c7a6794","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2882","original_object":"UniProtKB:P04150"}
{"id":"c466c2f8-5341-4ce0-a1dc-a04e0e313eb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73442760","predicate":"biolink:affects","object":"NCBIGene:2872","sources":[{"id":"urn:uuid:de88b869-6b3f-48c6-afda-5c8ae939d2fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9366","original_object":"UniProtKB:Q9HBH9"}
{"id":"4dd8da36-8f19-45ed-85d7-0f0d51266597","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:4fca9109-1513-4c1b-b74f-e171adabbdff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P50406"}
{"id":"e38d0569-64cf-47a5-acbb-b2a88cd0275f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0TJ631J0KP","predicate":"biolink:affects","object":"NCBIGene:5603","sources":[{"id":"urn:uuid:3e226bab-af66-48bb-a1aa-50cb1b3ae52d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8179","original_object":"UniProtKB:O15264"}
{"id":"73a69563-5a0c-433e-a484-aa9507df1d23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44288042","predicate":"biolink:affects","object":"NCBIGene:4316","sources":[{"id":"urn:uuid:37c45875-a9d7-4991-9960-ea0ac9587b60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8567","original_object":"UniProtKB:P09237"}
{"id":"61f88de8-2aeb-4413-86a5-137b324a667a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LG47VG1ID","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:9fbfd601-6a54-459f-986b-e7349a675320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:380","original_object":"UniProtKB:P0DMS8"}
{"id":"af74d40c-c882-4c72-88cb-33f3de17f0cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:695fcf80-401f-4821-b103-7305e420e50d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:P48730"}
{"id":"e5d7b807-0b8d-41cd-81cb-08fcf9b407d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92099","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:ddedb175-8465-4388-98ca-e63a76c4ad8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3303","original_object":"UniProtKB:P21917"}
{"id":"acf0ef13-f4b7-4423-92f2-eca63eb822b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73297","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:682b1579-a69b-4447-b6e0-eaf2adb50073","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:943","original_object":"UniProtKB:P21728"}
{"id":"c5352ab4-2447-4057-85a4-06abb773c3d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90643548","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:aee16597-b58c-47d6-b5b3-57a0bc5ac6b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8217","original_object":"UniProtKB:O00311"}
{"id":"5b0c3f78-234a-4e39-b3e3-52c09e22f6d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:389c6a67-d668-47b6-bbd2-7d4d55d59aab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P08482"}
{"id":"5b35aa1a-3d76-45de-a0ae-424786a4254c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:e019e5e6-e8e4-4143-b85d-f9337a804203","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P08913"}
{"id":"ffefa06a-c213-4e9b-9f36-f0d9dcc4d4fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13870","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:cdfa7a3c-08b7-477d-a999-91a1d5125824","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13870","original_object":"UniProtKB:Q12809"}
{"id":"db1674e5-ea72-48c0-9538-ebc0d2e97a83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64317","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:d7971267-229c-48fe-b9b0-32b72946fbd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:536","original_object":"UniProtKB:P07550"}
{"id":"d6a05e58-8a43-4b53-a6cd-b863cc7e900d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9923127","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:f2a99b03-1f82-49f1-b489-a713c2883947","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6206","original_object":"UniProtKB:P23385"}
{"id":"57722481-283f-49da-98ec-21149d5ad0b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030520","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:91b935bf-1668-4608-9d36-b10cc3fdb26d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10428","original_object":"UniProtKB:Q06187"}
{"id":"6bf2c931-6b80-4756-a581-ddb017269233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:752","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:e32a0c0a-9448-4e43-868b-868c9a7cebea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:752","original_object":"UniProtKB:P51681"}
{"id":"c3af83f4-8b28-49d7-b1bb-0cf5d199988f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WTV8EPZ396","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:7260caf7-ce3f-40e5-9ff8-5cfd554103db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7452","original_object":"UniProtKB:P43088"}
{"id":"205ab2cc-2714-4f01-9c6b-cf892ef3b5fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b2dfd6ed-1729-4c96-a23d-813f38c80762","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P08908"}
{"id":"153fa42f-e67f-4651-91e1-4e002ade1ba4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11310142","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:74962952-3378-4d35-bf2c-ca0606ee54fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11614","original_object":"UniProtKB:Q14832"}
{"id":"518c4ad8-2347-43d4-a4a8-d2c79656d465","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135947","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:9b71dc03-9470-44c2-93aa-d460e960e342","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7355","original_object":"UniProtKB:Q92731"}
{"id":"ca8917be-14c7-44f2-8d90-2dbb4d3e07ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138236","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:7ea21cd7-d28d-44dd-8d5c-e77741918d7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13088","original_object":"UniProtKB:P31751"}
{"id":"67249f6a-3dad-4c86-8ff3-8bb38aa3d7c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164885960","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:1ac4c162-f5f3-4e64-b2ca-256b287f35d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12150","original_object":"UniProtKB:P0DMS8"}
{"id":"25720515-b678-430e-9395-31a2999d9642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91810435","predicate":"biolink:affects","object":"NCBIGene:10765","sources":[{"id":"urn:uuid:e856c341-7471-4b61-aaa8-6222343b5f03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8576","original_object":"UniProtKB:Q9UGL1"}
{"id":"a2d206b5-154a-4984-b6ee-6c6e7455af76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:01df6200-3fba-415e-b6a2-1efd9345ab4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:P32745"}
{"id":"81efd65e-7c37-46f5-83f0-1d6eb00b5b32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10593671","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f3c60df1-1991-4bd1-898b-e22790236f06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:397","original_object":"UniProtKB:P29274"}
{"id":"2dfd0ee0-44d7-45c2-a75b-0b7bc11f6124","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1987175","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:03724fa9-00d0-4197-b268-3493eb663215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9283","original_object":"UniProtKB:P43116"}
{"id":"4f9c0d1d-879e-4a65-834e-a42fbfb72cb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45749","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:e53575f7-4cf8-4b21-a546-3933bb89e670","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2088","original_object":"UniProtKB:P29371"}
{"id":"ea4ff8c5-fc9e-4860-b84e-f01372f767c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:694752cc-23ce-4418-bc35-01d493aab321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:Q91ZY2"}
{"id":"9a7166a1-3780-4df5-bce7-efe788fb69f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5778","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:94c75424-ee8c-4545-b3e4-1a5a87e64801","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:4836","original_object":"UniProtKB:Q6IQ20"}
{"id":"1e1c038e-2efc-4ded-85dd-034206271ccb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24794417","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:61532567-dc32-4c41-a393-913f2efe0125","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4168","original_object":"UniProtKB:Q12879"}
{"id":"61252f80-6031-469e-aa80-169d00613eb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46866192","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:3281f305-91b6-4f0f-8aed-6cdf5b299149","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6210","original_object":"UniProtKB:P23385"}
{"id":"9c77f72e-c938-4522-aced-e42417b065bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53380803","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:9ece4173-93b8-4274-abc2-04409dbf2fad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6309","original_object":"UniProtKB:Q6RI86"}
{"id":"321d44b7-b9cb-4ef1-b92a-dead551586eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93039","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:0f874719-2f7e-42e2-9eb5-01d6d8645c72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:741","original_object":"UniProtKB:Q9Y2T6"}
{"id":"d426b327-69db-435f-934d-96f5f3908041","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58141","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:a4b6d436-ef1f-4bea-8b35-d7e6c1c35327","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1732","original_object":"UniProtKB:O35811"}
{"id":"96764ff1-3a16-4bb0-a54c-156cf6274e7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9324","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:9e91f180-749e-4d7b-8cfa-4f9a1605c476","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9324","original_object":"UniProtKB:Q8TDU9"}
{"id":"30ffd668-2e0b-4364-ba95-e898124dcd26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P7186074QC","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:ff75e417-66ad-4476-9bb6-a02a9b9ac9d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9801","original_object":"UniProtKB:P55899"}
{"id":"bcfe74ee-0d97-4ca8-a70a-641483885b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2045","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:8c122728-4d48-4b0f-ac83-485a6dc59bf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2045","original_object":"UniProtKB:P32745"}
{"id":"f42287ef-03d1-4e5c-88b2-928ac64989c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10282223","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:5287b36d-1003-4124-b173-8958c75722af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2909","original_object":"UniProtKB:P61793"}
{"id":"568a1882-7a4a-430e-a483-4785f4d74aa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2704","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:c3b6f10b-f811-49c6-9117-e65dfa1f87a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5137","original_object":"UniProtKB:P11511"}
{"id":"472ef62a-63ee-4e5c-95bc-c51472efe55f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:353174","sources":[{"id":"urn:uuid:155cf5c3-d7d3-403f-b05e-e99d8156c62d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q401N2"}
{"id":"109998d7-f582-4528-a1ae-3663b0888490","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:4139","sources":[{"id":"urn:uuid:ed94986f-24a8-4587-a86a-74e9bebdd35c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:Q9P0L2"}
{"id":"10bf0a54-e60b-4e8d-8f27-1c58113a4a08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10500941","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:732fab2e-8a03-4d48-b45a-dbb56278665d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:393","original_object":"UniProtKB:P29274"}
{"id":"885b41b3-c533-46ea-a8ed-90d08d8f6efb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50438","predicate":"biolink:affects","object":"NCBIGene:79001","sources":[{"id":"urn:uuid:2d24ced7-bc4c-43a7-9e20-016a66839822","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6839","original_object":"UniProtKB:Q9BQB6"}
{"id":"9cab29c6-503c-40ae-8490-4cb74d050267","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3360","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:92aebf0e-de39-4c6f-81f1-76f1d5f6b518","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:740","original_object":"UniProtKB:Q15858"}
{"id":"74eceaa1-3a0c-446f-8d97-a79be442f3d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2565","sources":[{"id":"urn:uuid:e4dde82a-d45c-4bcb-a198-759a37bf91b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:Q8N1C3"}
{"id":"6b4d963b-be99-494d-b327-8510d3e057a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4470","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:1457a778-c7bd-45b3-ad8a-6dc43173762b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6953","original_object":"UniProtKB:Q14957"}
{"id":"24fee297-d6d6-4f26-ae13-b2189b91469b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:4dd00a57-226c-4e51-b3db-0436a664b675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:P35968"}
{"id":"378266ed-4aa2-4dde-854c-10659ffb0030","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118291958","predicate":"biolink:affects","object":"NCBIGene:2160","sources":[{"id":"urn:uuid:d61ad790-51ca-4ea4-9830-20da686213aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11990","original_object":"UniProtKB:P03951"}
{"id":"0c4bf950-8bc8-44a4-82de-c5f486f38420","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3774","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:1e9e25f5-b889-4509-9ddd-18c141179044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3774","original_object":"UniProtKB:Q9P296"}
{"id":"91d35efd-7479-4fb9-a9c6-d8e729c576c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122177620","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:e87aa4d4-4058-4285-84bd-a65587fef04c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11471","original_object":"UniProtKB:P78348"}
{"id":"d085b452-9c1a-4dc3-a812-003b03ac51d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:79e039cd-f7e1-4933-9184-72ce101022bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P09619"}
{"id":"e6039895-f757-458b-b468-4cd0bb2812fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:486830","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:e6d88c98-0787-4e7e-8527-ef24cd54f645","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:768","original_object":"UniProtKB:P61073"}
{"id":"dbef90af-8752-475b-8aed-e15603995101","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9385","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:af720675-a393-4907-9a58-1df0d1f0477d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9385","original_object":"UniProtKB:Q9P296"}
{"id":"70c76187-93ad-4146-9b9c-02d9247347db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45302","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:3561e956-a17f-4b52-bb5b-3e424c677d5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6023","original_object":"UniProtKB:P42338"}
{"id":"1b881572-0341-4f10-90a7-372f4edfd3d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EW71EE171J","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:6882e85f-60a4-446b-a983-9e762a900313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:185","original_object":"UniProtKB:P41595"}
{"id":"f594a53d-5955-4dfc-b6f1-8c14327a95aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16761","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:5cf7a408-8aba-4da2-9010-55438417513a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1712","original_object":"UniProtKB:Q8TD43"}
{"id":"c0c5ca36-8705-4c8f-81b4-95c18d6d56dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K4I4I996O4","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:08914b3a-9895-4911-b7a9-33f6a52d65e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12787","original_object":"UniProtKB:P08183"}
{"id":"4b40bf53-a8ae-45b3-b319-d1b0104e4386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:823","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:6e08100d-1ea1-4bd9-a79b-3c24012b6a8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:823","original_object":"UniProtKB:P25024"}
{"id":"b0827429-5f45-4ace-97f1-ccbc8dc9216c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229212","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:4c0b1e28-1fef-4738-ae9f-c8312bcca1e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11628","original_object":"UniProtKB:Q06187"}
{"id":"d022d8d3-df3d-48f2-84ea-63d9e0b53b09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11611423","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:c33eb7f7-dbad-4343-a272-f80f11252fc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2572","original_object":"UniProtKB:P15387"}
{"id":"9428b59a-4af6-4ca2-88b3-a3e1395b034e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755221","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:5ea33808-47fa-410f-ba15-2c18c724aaa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6433","original_object":"UniProtKB:Q8NFJ6"}
{"id":"666895f3-e859-4121-b305-cad2e53de74d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54210200","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:26c10bd0-68aa-4457-90f1-7eb266cc7ea8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5907","original_object":"UniProtKB:P41231"}
{"id":"e90eb721-c1a6-4572-b9fa-7d23330bae04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996528","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:e18b0e52-fa0a-4274-93f1-29ff2ea01c9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10603","original_object":"UniProtKB:P43116"}
{"id":"4885f25f-0871-437e-905d-347a7c95a7ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:4950e46e-5eb9-4694-b055-0d345e5de583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:P25929"}
{"id":"3634abcc-b313-4a1f-8735-6f3d99ede2d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817483","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:6e59b5ea-e0fa-44c3-998d-d5bbfaf965dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6094","original_object":"UniProtKB:O08726"}
{"id":"6f9b29fd-d337-4425-90e5-7080d0e728f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125406","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:8359910c-7eee-4724-80d6-603305e398dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:132","original_object":"UniProtKB:P28221"}
{"id":"8c21be8a-483a-438f-988d-72d17c24caf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:009f333c-a0d5-4efd-9356-e8e168788afb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P28566"}
{"id":"d88d96d2-4413-48ed-a1d4-5db9eed36335","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43561","predicate":"biolink:affects","object":"NCBIGene:85259","sources":[{"id":"urn:uuid:dc433a1c-fc41-4921-bcfe-affa03aa1f5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2348","original_object":"UniProtKB:Q62927"}
{"id":"e194a2e7-ae16-45f2-b0f3-286b5fafaf77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:1fd4c2d5-8493-49f3-8fd1-8f894aae30c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08483"}
{"id":"602ae329-02a8-4a55-bf52-e3261bf4b94b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2052","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:5979163e-fab2-4c23-bda7-23a50f566832","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2052","original_object":"UniProtKB:P32745"}
{"id":"b535597f-31bf-411c-ad64-43b43c15e04d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9245","predicate":"biolink:affects","object":"NCBIGene:7293","sources":[{"id":"urn:uuid:0a48eca0-cad2-4e11-935f-006b8c1ec5a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"antibody_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9245","original_object":"UniProtKB:P43489"}
{"id":"8a77e415-09f0-4880-9393-9e039f2d2357","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:22ee615b-7b14-43bf-8b3f-2c24bc76d31e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P29274"}
{"id":"da13d665-9e5d-4188-b2cd-a81827dc427c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6SVX956NTQ","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:e7e84fdc-d97b-4d91-b5a1-197b1a89e1e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:546","original_object":"UniProtKB:P07550"}
{"id":"3777f24d-c5b4-4574-9648-58510c9fdf2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54KY638G8W","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:cf262bd6-eded-40cb-8f53-df342b50f08f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2633","original_object":"UniProtKB:P10827"}
{"id":"c47cc57c-a571-45a9-bfd0-b12e9fc539b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900914","predicate":"biolink:affects","object":"NCBIGene:9263","sources":[{"id":"urn:uuid:161ec217-ad2e-4bbd-b4be-b04d8d3e8542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11894","original_object":"UniProtKB:Q9UEE5"}
{"id":"f7efdb25-51ca-4604-aeb1-bd827e4dd0e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5391","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:88947902-1152-48ab-abbd-0934ae7c5a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1136","original_object":"UniProtKB:P43220"}
{"id":"bbe201c2-92b5-4d46-a561-ddf389c348b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8CZO0970G3","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:fb22b1fc-618b-4c41-8c51-35b511187748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4241","original_object":"UniProtKB:P14867"}
{"id":"acdec94a-233d-4023-8763-3f442e552c32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4292","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:79a0b0d8-5385-48a3-b376-e7d2c6e59658","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4292","original_object":"UniProtKB:P78348"}
{"id":"71b666b6-a88b-4d29-afd4-b35384937d1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:USO2D5J77R","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:c9b25ea9-0e07-4162-ae35-3a80873463d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12649","original_object":"UniProtKB:Q12791"}
{"id":"fc4066c0-f1c8-4d89-9052-17792a058298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:04c6a57c-5fdd-4218-a824-05d09ee358bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P08913"}
{"id":"c378854d-ef7b-4143-9422-055acf8b2569","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:193137","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:b7aa4c77-eacd-48f5-8778-32a8bd063cb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7912","original_object":"UniProtKB:Q13490"}
{"id":"ea0435cf-a23c-40dd-b85b-8307ac398d0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:2b7797a7-4ec9-4f31-8817-c98de68bd0df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:P70605"}
{"id":"034f6da6-35d5-4610-9e35-eb01e42fb734","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177401","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:e2c1288a-a5df-454b-ac3c-5cfd62916b7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2886","original_object":"UniProtKB:O43614"}
{"id":"b04bed56-9f96-49f9-820c-3355017256c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19088577","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:b747a9de-dec5-40a9-b581-9ce8236f2536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1977","original_object":"UniProtKB:P21731"}
{"id":"5514b84e-a695-4831-ab58-8e651b7fbdf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:99e20b54-cfbd-4c49-b0a1-e4fc7efb4c95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P08913"}
{"id":"37090dcd-3c32-4946-989b-e9301fd6998b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197107","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:dfd951f5-66eb-49d0-930d-29fab3e9f892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7906","original_object":"UniProtKB:P00519"}
{"id":"94a9f9c6-d4dc-4b9f-be62-34ca051e0eea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1121","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:9aad03c1-9adc-4743-ade2-62df3cf8879b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1121","original_object":"UniProtKB:Q02644"}
{"id":"3fc82196-135a-46aa-860c-36415ca81bb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10310632","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:3b4ae741-694d-4c31-8d21-da609b40e36c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9021","original_object":"UniProtKB:Q99572"}
{"id":"ede52ae5-2337-4205-a0b3-ed0dc6e82b8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:1a03e604-23a8-4798-8f97-f81c3eab2b42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P28223"}
{"id":"fd6005d6-a82b-4a09-93ae-2b0e3fb04ea8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:33639WNC7Q","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:337bf9ab-f3ae-40e9-a223-98da5c281dc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8793","original_object":"UniProtKB:P42338"}
{"id":"df93d513-0b04-48be-9b78-28535be8c7a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2057","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:2906df10-2918-47fb-a9be-0708b55b3fb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2057","original_object":"UniProtKB:P30874"}
{"id":"7a84108f-7845-4949-a3f9-77b8a7919e5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:867fef2b-a234-4fce-8088-42ea9c996cc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P23944"}
{"id":"01a425e6-4095-446b-9aa5-2b7453b157bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34973","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:53c94a57-c8ab-437b-995c-609234253f13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4155","original_object":"UniProtKB:O15399"}
{"id":"97da1ccd-8abb-4acb-9644-c5957e3a858f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0G7D0CQ88I","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:a89d82a9-669e-4122-ae1e-32adb1fe32d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7721","original_object":"UniProtKB:O95180"}
{"id":"6a1adeb7-bf75-4507-a33b-1716dcf8de75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:fb44dcdd-83d9-4437-a2ea-8191a4781300","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P42345"}
{"id":"8abfc8ec-98ad-4260-8763-5c31d3f89003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64117","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:23d6b22c-1b93-4c43-8895-8afeb60ab283","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:970","original_object":"UniProtKB:P35462"}
{"id":"f654baf8-1e49-4313-97bd-1413783603c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1571","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:354c5579-5a2e-494f-a917-437793e1fb51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1571","original_object":"UniProtKB:O95665"}
{"id":"c8c98163-cd6a-4d19-ba61-44a6e6f430b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:9020","sources":[{"id":"urn:uuid:60afbec5-5a25-4f1c-99b0-7c0543936749","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:Q99558"}
{"id":"ac89e722-38c8-4b46-bf0f-475d88323286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139557","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:53971a86-001c-4961-ab10-fa2137b1c0b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3489","original_object":"UniProtKB:P34998"}
{"id":"da40bf8f-1052-4bf1-b432-d86578f0b847","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:635","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:44af0051-ca2e-471c-b142-4d7fc0d3bc0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:635","original_object":"UniProtKB:P28336"}
{"id":"5f0cf2dd-a227-4b8e-b89f-1b1420d8be86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94609","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:42646094-edd7-4b80-a90c-091b9e4d569e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:356","original_object":"UniProtKB:P02708"}
{"id":"9edc1413-1d83-4812-96dc-3834caff7aaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:631105","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:3e0d61ff-d208-4f34-a669-aa676484fa14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:401","original_object":"UniProtKB:P25099"}
{"id":"727b7578-3cb4-4e2b-a0f9-e01ce2ffd425","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827370","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:92ef45ec-52ab-4ea5-a33c-33613629471b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8548","original_object":"UniProtKB:P15056"}
{"id":"01d37361-09e1-4b9e-9913-e59949f46779","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131166","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:61dae6b0-d021-4cf9-b40f-aa1d19f3cab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8003","original_object":"UniProtKB:Q13315"}
{"id":"e6b3f761-28fd-4b6f-8066-580d75bf5189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64069","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:1834db3d-f29a-4695-bddb-f7d3658b6952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:130","original_object":"UniProtKB:P28222"}
{"id":"95baaf34-5229-4450-be08-45a2e8a4ccbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4U62D8JYIQ","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:6e974d55-706c-47e2-bbbe-cd3cad270548","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5784","original_object":"UniProtKB:Q8TDS4"}
{"id":"953bd6ce-b27f-4e12-ad2a-ef73e5be05f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117961403","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:463115e2-572b-4e35-b1b6-d0edb55e33fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10394","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"59a9ca4d-4c88-4118-836e-3680b64499db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6706","predicate":"biolink:affects","object":"NCBIGene:1135","sources":[{"id":"urn:uuid:c5331f72-4e08-4bdd-9e35-5a272e32a22e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3990","original_object":"UniProtKB:Q15822"}
{"id":"2a4ca389-e453-4e4d-ba11-5eae5ea67d97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:283FTA936D","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:940b532c-3436-4165-9dc5-be84ee7ff1d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11493","original_object":"UniProtKB:P21453"}
{"id":"e3842ffd-28a8-4d27-b3b4-f419793d9c5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79992","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:66341c6b-cea9-44ac-b162-63768793c9d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2703","original_object":"UniProtKB:P37231"}
{"id":"3023ae5a-07b6-46e6-8de6-f58ad96ec7ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11842633","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:5456fb85-bd77-4a4e-a381-f5e995424f46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8425","original_object":"UniProtKB:Q13639"}
{"id":"f5838d80-8da9-4c84-9be0-47e2099a3cda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49868481","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:c421b882-e4af-4e40-bca9-f241fe043faf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7585","original_object":"UniProtKB:P43220"}
{"id":"6fb6645d-32cb-4c9a-b51e-3dcf248150f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:5480ea66-4a9e-4e6b-bb11-d3e82bd8cd50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P28476"}
{"id":"5959ff7f-3279-44bd-b1c9-189b99539624","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5288598","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:1339a1f7-5652-4adc-a270-f8c5d0589c76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4069","original_object":"UniProtKB:P39086"}
{"id":"1a58af73-8949-4782-a4ea-d1899795b2de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4293970","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:20d289e4-5fc8-4203-811e-8fea7e2729a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10151","original_object":"UniProtKB:O00329"}
{"id":"0f106188-7c3d-4753-803f-7b07774832e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8925","predicate":"biolink:affects","object":"NCBIGene:2042","sources":[{"id":"urn:uuid:9251676b-a389-4851-bcc3-8879b07d2895","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8925","original_object":"UniProtKB:P29320"}
{"id":"589b06d0-7a3e-44a3-93b6-a1fe5a227ae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:58a79b76-8a28-4239-a5d9-607d3881c6a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P35462"}
{"id":"ff2d100e-69b9-42e0-a28c-f7426f53290c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817525","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:414a47ca-7e91-4112-a480-b4ef4dcbb190","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11473","original_object":"UniProtKB:P78348"}
{"id":"8c5a803e-2798-4b23-98e6-c0aabed5a8ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:343","sources":[{"id":"urn:uuid:e1f1b7cc-16aa-4260-8838-d93e09ffb9b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:O94778"}
{"id":"dc7992d8-fb02-4bf6-af2d-9a91443e6407","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10176414","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:79058dbd-78ba-47ae-94e5-1645db0bc09d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1246","original_object":"UniProtKB:Q9Y5N1"}
{"id":"ad67192a-fa4f-4ca9-824d-1879667326ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:142503719","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:310d6537-dd2c-466c-9ba5-1e98c87052c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12303","original_object":"UniProtKB:P11229"}
{"id":"5bfc0210-7c30-417d-859b-d633ea7e6021","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4164","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:efecc9fe-304c-4d9f-af83-314696ba1311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4164","original_object":"UniProtKB:Q8BLA8"}
{"id":"79957960-84fc-4218-94de-0a7602c6836a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9738","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:ff55f848-54df-4b5f-957a-302dd181ed51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7317","original_object":"UniProtKB:P31645"}
{"id":"317169c3-0f8d-4c3b-aaef-0c5a062a4653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3Z11398FNQ","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:5d75893a-5bf4-452b-9667-15334b01acec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12768","original_object":"UniProtKB:P10827"}
{"id":"03ded8d2-cbea-4e80-a0ad-b693c276713c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817471","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:5396479b-241e-45a8-abbb-692f471a7137","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4449","original_object":"UniProtKB:Q03431"}
{"id":"d93d43da-85b4-4afd-ae82-6c3b0a6201de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190962","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:f51ca4c6-2fb9-4915-b74c-d5cc37acf2c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2460","original_object":"UniProtKB:Q8NER1"}
{"id":"aef89dbd-407e-4655-972b-1d8782877fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:ff0b197a-a68d-4517-b229-f9170556b054","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P21917"}
{"id":"f2ccfd3a-8545-443f-8ecf-a435f9e10c45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16725048","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:ffa03458-1b1c-4443-8220-89fdb983a0b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6362","original_object":"UniProtKB:Q13255"}
{"id":"7a6de1c2-e804-4188-94a0-2712ce5ac5ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:9f04b141-52a0-4ae6-a16e-aea9f285d745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P30874"}
{"id":"2ac06a9d-6f89-4b46-9008-1ac5bca179da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:14D65TV20J","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:5f07ff8d-971c-4bfd-9c48-48cbd5236e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8863","original_object":"UniProtKB:O14965"}
{"id":"12565c24-aa78-499a-9a18-0879df5ba21b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80345","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:49ee2e1e-ed9e-4108-9062-7f628b61ca0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:860","original_object":"UniProtKB:P32239"}
{"id":"edcdf109-28dc-4582-bcb6-2bbd5c1923d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:127b9c1b-dfaa-4e7f-b4bf-17fd4a959edb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P28223"}
{"id":"71f4c8f8-3680-4e24-b38b-a30835bcf796","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63937","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:eb6ef2f1-cbcc-4b16-ac59-7aba8327a09d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:486","original_object":"UniProtKB:P23944"}
{"id":"bd21b623-29e4-45d1-a27e-059439b67655","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44321610","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:2df302e2-5eb4-44fe-ad48-f548b416f036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13835","original_object":"UniProtKB:P08473"}
{"id":"729dac4e-ffec-4d72-98ca-8fe486e05be3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:b0c712ee-6e9a-4b61-8272-dd8e44cdb9f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P30543"}
{"id":"badc74ab-c7de-4439-903a-32edd4c1f288","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2583","predicate":"biolink:affects","object":"NCBIGene:16508","sources":[{"id":"urn:uuid:00f989f2-2804-4406-bafc-2e01865f4934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2583","original_object":"UniProtKB:Q9Z0V2"}
{"id":"7bcb4f58-c47c-470c-a0d1-4644bf4a785e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1469","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:90d3f47e-1256-49ff-afc9-a94ef5d818c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1469","original_object":"UniProtKB:Q9GZQ4"}
{"id":"50b3ab4a-bbef-47a3-9867-ce48827752f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8238285OA","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:7fe648b7-8413-4e2f-9076-f95b8700b56d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9307","original_object":"UniProtKB:P56719"}
{"id":"795bcbba-d41a-4f9b-9ab2-3cfd94eb9520","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87283","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:db4456cb-4662-4048-bf70-261aa017d4b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9371","original_object":"UniProtKB:P48730"}
{"id":"59b02cde-6c09-48fc-976a-81dd22ed0446","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90848","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:c1323f0b-eea8-420d-8ea4-e83b709a9241","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5852","original_object":"UniProtKB:P43119"}
{"id":"c03e7239-d541-4b99-8c7d-276363a7a8eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7DR7JMB8BH","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:b1eb1332-f7fe-4526-b3c8-1c5a4c412178","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8959","original_object":"UniProtKB:Q9UM73"}
{"id":"54c0326b-8775-4fac-a5e1-52c702e1bb17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:25187","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:5399a090-faa8-427d-bebf-d1fe16daf64c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2430","original_object":"UniProtKB:Q7Z2W7"}
{"id":"72958bd6-c642-4cba-9d35-3d2fc1374830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LW8QB286HN","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:82ceb3f6-f688-41b3-aa3b-421538ee8624","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8096","original_object":"UniProtKB:P35968"}
{"id":"7bb42be7-4fe8-4fe0-961a-f586f019ca5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:11540","sources":[{"id":"urn:uuid:69a89c9d-8e88-4084-9f2f-d7a2ab65a5e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:Q60613"}
{"id":"01d0d3ae-e75e-4885-b394-803567fe66f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827373","predicate":"biolink:affects","object":"NCBIGene:23774","sources":[{"id":"urn:uuid:5052e9a7-241d-4994-9aea-5c3ce75053f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8573","original_object":"UniProtKB:O95696"}
{"id":"9fa019ef-7095-4a39-ad58-fdd3c9bafecf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:4d20fcb5-1a3a-4c18-9507-ac5637c122c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P28222"}
{"id":"5fe90d44-5293-47f8-8a48-76a27d2beef5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:441","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:e4765942-e7cc-4987-a4f6-8395604764c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:441","original_object":"UniProtKB:P29275"}
{"id":"c8fa0d4f-796e-484a-bad6-c4848e09d99c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9838905","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:679126a3-6423-48f8-accc-04a2571d6e15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1243","original_object":"UniProtKB:Q9Y5N1"}
{"id":"09668c85-1300-4865-a0a6-346e34949e67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46937439","predicate":"biolink:affects","object":"NCBIGene:5338","sources":[{"id":"urn:uuid:0885bebb-3d1b-4c17-a39c-a6f25a11df65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5287","original_object":"UniProtKB:O14939"}
{"id":"3d0655e9-85e1-4cf0-a7bb-ea7ce7a2530d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G2AE2VE07O","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:97355177-5809-4737-b1a2-2633a40ee6f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10129","original_object":"UniProtKB:P08172"}
{"id":"e1da87ee-55e8-4c6b-8d94-aec1cbb91f67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5122","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:24bee1f1-7d0b-46c9-97fb-428bd237a26b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:279","original_object":"UniProtKB:P34969"}
{"id":"60c445a0-c85a-4f19-bb62-2af01b817bcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2029","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:860f02a0-0333-486a-b760-2198ee9ed3d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2029","original_object":"UniProtKB:P30874"}
{"id":"ae69a053-0c9c-4eb9-af06-35f3af9cb154","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230352","predicate":"biolink:affects","object":"NCBIGene:112398","sources":[{"id":"urn:uuid:e473e7a0-ab4a-4c41-bf98-06118ebcd926","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12285","original_object":"UniProtKB:Q96KS0"}
{"id":"4ce5589d-a85a-4319-bcd6-d9caf493193c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50693","predicate":"biolink:affects","object":"NCBIGene:5138","sources":[{"id":"urn:uuid:28f69ba6-ebf4-4c67-8278-7bf5ff5de6b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5225","original_object":"UniProtKB:O00408"}
{"id":"ed4d52d1-4b25-44ce-99c8-0e472fe82f4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0N48AL0PRA","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:65ac6b90-05bc-4af5-9824-0410acaf6866","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6502","original_object":"UniProtKB:P12821"}
{"id":"eed0c21c-fc4c-4794-af34-d87fc5af3e0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154578372","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:aa534f71-372f-4096-95cd-5efeeb08139f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12542","original_object":"UniProtKB:Q9GZU1"}
{"id":"2b4527bb-c316-4f63-be0e-ece9ec08f2ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70735","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:508334c6-c088-435b-884d-72804c6f5391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7461","original_object":"UniProtKB:P34969"}
{"id":"37114fc7-779a-404d-b0b7-3de9c9e81571","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30915","predicate":"biolink:affects","object":"NCBIGene:27199","sources":[{"id":"urn:uuid:c87fa0f1-5ce6-4d92-a3b1-9bb4438e5de1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3636","original_object":"UniProtKB:Q96P68"}
{"id":"10a5a986-de8b-4a67-a9e4-9a7eceeb2d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92667","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:b77434ad-535e-4041-9da7-c8163b56b9ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:448","original_object":"UniProtKB:P0DMS8"}
{"id":"a1e97834-f7c5-4828-a17a-43540e1b88c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:83b5deac-4d5f-4be2-9886-5f40f3e1d898","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:P33981"}
{"id":"3e8e1479-0bab-4fb1-9902-c22ae4a1cfcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36795","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:673e0a23-0eab-406a-aca0-e9e847c5fe6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:202","original_object":"UniProtKB:P50406"}
{"id":"3cfdae0d-c4f0-447a-8f19-ede9b9a8d0ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:35C6UMO5SR","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:2eee105c-7cc2-4588-a031-d00c7ff8bcc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:101","original_object":"UniProtKB:P28335"}
{"id":"ac0fcc6d-32cb-4c6c-a067-90eacae716c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233593","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:60bc52cf-03c2-41da-9e66-2ab0a914a9b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9913","original_object":"UniProtKB:P00519"}
{"id":"f5b59b80-8ff4-4037-b5d5-6dcfa63587f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153572662","predicate":"biolink:affects","object":"NCBIGene:11091","sources":[{"id":"urn:uuid:695f46de-ec13-4d82-90db-9ec613515307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11999","original_object":"UniProtKB:P61964"}
{"id":"37d5091e-e960-4c64-a5e5-b11eca49b46e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"UniProtKB:Q9JIS7","sources":[{"id":"urn:uuid:9ae387d8-496e-4412-9f93-3cc52032e8e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2406","original_object":"UniProtKB:Q9JIS7"}
{"id":"d10bb0a9-2c86-4f4f-b1da-e4584c479114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9573","predicate":"biolink:affects","object":"NCBIGene:2842","sources":[{"id":"urn:uuid:39174330-3862-4dd1-ba77-072d1d1b6759","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9573","original_object":"UniProtKB:Q15760"}
{"id":"31673a77-7219-4df2-9dd7-5c890f354b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2N9Q4C7WMT","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:08f93cd6-3897-4b38-bd0f-2b4a3a45cc77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4066","original_object":"UniProtKB:Q05586"}
{"id":"9bfd6f46-eb62-4aa8-b692-38b2de1b610f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101085","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:e7606458-cac1-4742-a658-63fdf5f64445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6807","original_object":"UniProtKB:P00915"}
{"id":"3d980849-5243-4505-9bc4-13d0c4bf260b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:fc3e7b4a-aaaf-42b3-a32a-dd7cf472c072","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P70597"}
{"id":"18ae9da5-0435-4176-be20-bd7f38fe08d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129665","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:7a2c1e2c-a096-4191-99f2-649454ea2561","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1155","original_object":"UniProtKB:P30083"}
{"id":"92765df1-076a-4e86-b478-a674de97fda3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166177189","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:5e6cff11-1237-47ba-80f5-d1eec9b4e750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12518","original_object":"UniProtKB:Q07343"}
{"id":"a7617723-6a12-4e93-916d-9bb1ce3e7cdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66524380","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:81d9e5bf-8d95-4dc4-944a-809b65a70a5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5695","original_object":"UniProtKB:P07333"}
{"id":"49441230-5df3-4d3e-ae58-7171c6472b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QB6LNL4NF6","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:21ce117f-c943-4354-99d3-4a0b6a30de34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9187","original_object":"UniProtKB:O14757"}
{"id":"811a30ae-29d3-48aa-95b6-952b3c7311c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72441","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:786d961d-2ed3-43ec-8de4-2ddf53498468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8372","original_object":"UniProtKB:Q9UL62"}
{"id":"7ca1fb1d-c722-42a5-83fa-824248565b96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3869","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:55032891-d2e0-4628-92b3-b8c7ff825446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3869","original_object":"UniProtKB:P30518"}
{"id":"82f46c4c-6abd-490d-9f00-4d1a3bcbad32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:612","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:7af56d3f-b678-494e-9564-4324d64c3c6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:612","original_object":"UniProtKB:P30550"}
{"id":"5d28c3ae-8be5-4d61-99e0-26cac7dba8d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233436","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:ae6cb37b-9e8f-4375-ae8f-e1394fb94192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10625","original_object":"UniProtKB:Q06187"}
{"id":"b3caec8e-48f0-4dca-996d-b11983869352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28820","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:542651b9-f691-4e25-84bd-9954a62db097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4114","original_object":"UniProtKB:Q8TD43"}
{"id":"43dfbb20-6986-4e4f-933d-217381d0431c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YB1F0V77MK","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:947a34d2-6830-4a1c-90cc-58a1834d0aab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6155","original_object":"UniProtKB:Q9NPC1"}
{"id":"ff283011-adbc-4192-8938-3b3d252e11d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46909588","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:394de088-6e52-4b34-b8ba-d9dea05a9dde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9399","original_object":"UniProtKB:P33981"}
{"id":"6debeffc-6600-4090-bdf4-a7133cc0433d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6438","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:c67acf6a-9336-47a0-9b5c-94985c9d7540","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:570","original_object":"UniProtKB:P08588"}
{"id":"0b9a5233-f2c0-42d2-a729-c7a648756cb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9820129","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:56888e00-23e2-4589-8bc4-df482fa4fcca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3066","original_object":"UniProtKB:Q02769"}
{"id":"15716527-87b8-447b-ab62-85a431731752","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146368333","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:032a3bc6-fbc4-48a1-8cae-0f60eb058ff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11283","original_object":"UniProtKB:P43088"}
{"id":"726d26c9-8f45-4b0c-b305-930128e6f354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:820NH671E6","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:c4e962a2-3cbd-4c58-980e-9c60fa864b73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9549","original_object":"UniProtKB:Q15418"}
{"id":"92d0de65-1279-443b-bb34-870f5cab2349","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755151","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:5a9017c8-56dd-4378-aaf2-70a5767be193","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5743","original_object":"UniProtKB:Q8TDV5"}
{"id":"ea0729b2-7eee-4ddd-a03d-e1aa06eb165b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:94168F9W1D","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:5e0dc5bb-2965-4ce0-a330-fe7449262275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2089","original_object":"UniProtKB:P25103"}
{"id":"eae4bc26-d0a3-4171-91d4-68b6da35c59b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83531","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:6084ec38-1d2a-4283-8ffd-725d2e76112f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7428","original_object":"UniProtKB:P21397"}
{"id":"fde0edb4-2584-454a-84c3-e2b26a5547c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:299be3e5-7105-4889-b40b-48f420411780","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:Q13639"}
{"id":"3d229179-f6e3-4d92-82ad-0110640b8af6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:7a074ae4-a23f-4c4f-8934-62ae297d22d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:O75762"}
{"id":"70cf6035-def7-4dca-bf3b-1770e68ba339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93152","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:2d87e9e1-e36d-4683-85ff-cd76a6710ca6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1079","original_object":"UniProtKB:P31424"}
{"id":"160a34d2-6659-4ac9-83d8-0d602c2b8f9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:810","predicate":"biolink:affects","object":"NCBIGene:1236","sources":[{"id":"urn:uuid:dd50ce0e-3c9f-48ed-95f6-3e0bbbd6ed40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:810","original_object":"UniProtKB:P32248"}
{"id":"90840923-e072-4be3-9300-ad1c42a7fa9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HB4QD9GL6F","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:79a58868-a86a-41cb-acfc-c871e98f4d6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1607","original_object":"UniProtKB:P41143"}
{"id":"e09dc6c1-a872-4993-a232-4a2f5e926a5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132571","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:7b6a1322-18d8-436f-b679-fde20a19ee23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2643","original_object":"UniProtKB:P10276"}
{"id":"2f9c5efe-95dc-4f47-a25f-3290eba73767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184332","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:64868822-74b2-49d5-aa39-a88e865d4070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5417","original_object":"UniProtKB:Q8BLA8"}
{"id":"af83ef84-0937-43db-918e-4236b35e135a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46911068","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:36ca9924-577c-4413-ba82-c2f1fd7399fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6235","original_object":"UniProtKB:Q14833"}
{"id":"108f9989-d540-4adb-a255-3c0491c71c63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817488","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:2ddc8879-94c6-4e59-b2a2-09a8857de67e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6165","original_object":"UniProtKB:P24053"}
{"id":"ce474791-6182-4a8a-b0c2-7c290236c87e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:a3d60dbb-e2c4-4793-a0fc-2b829e5db44f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:342","original_object":"UniProtKB:P08912"}
{"id":"b3cb13c3-fb4b-4d51-9356-bc9c31f68f2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5487427","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:a976a019-8ba1-44a3-a3f0-dff170c56887","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:367","original_object":"UniProtKB:P11229"}
{"id":"daf78e2b-0ab0-4687-94b9-b15addadd71c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6136","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:a0db340a-f692-42ea-a1a6-23439a464e02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6136","original_object":"UniProtKB:O43603"}
{"id":"18593214-1775-4f0d-969f-1412fc5770cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:23f92e15-3aed-421f-8c40-4ef5d10879c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P22460"}
{"id":"a230ef4e-e774-4bc8-9feb-3c8d9f45a7d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10662370","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:8310b04b-09ba-4a9c-8a66-cccdd217ece0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3112","original_object":"UniProtKB:Q02769"}
{"id":"04384ce5-c894-4ea5-9830-74d7b4a0eafc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:084643b0-32cc-415d-93f5-0ec66f7a51a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:Q06187"}
{"id":"c614a46c-1ab7-4293-b018-a8bc48a4fdd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:3879390a-4493-4cc7-9b78-1daa9afbfbb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P30083"}
{"id":"27440c73-245d-4d2f-a2c9-347182d39365","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6K32LCR80R","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:53f96910-673a-4150-86a9-b04dcf2c9f2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5856","original_object":"UniProtKB:P35408"}
{"id":"cfe1e909-dd4f-40b4-bcdb-35d62e737e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311504","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:f1cee1cd-4cc6-4eec-a2a8-6bfcd4f0da25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3448","original_object":"UniProtKB:P06401"}
{"id":"d4920519-c550-4bf7-acff-65a1fe28bd1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:67168","sources":[{"id":"urn:uuid:1b2e2333-43d2-43ad-904e-2c88c0b9baef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q8BMC0"}
{"id":"a186a162-0eda-4af6-9a06-2c8ec20b2b38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11629817","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:833a65be-1017-4e1e-9bbd-4567d63ff6e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4099","original_object":"UniProtKB:P24046"}
{"id":"e8451c63-2ede-49d6-a687-496c0e5b4a3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:836","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:3cc2e628-a853-481f-9456-c010dfc3c9ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:836","original_object":"UniProtKB:P51677"}
{"id":"b9488945-3c14-4e28-a053-c961edf72302","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755252","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:ee7f8b77-1bf1-431b-b1a9-2382ec6e9ab0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6984","original_object":"UniProtKB:P61793"}
{"id":"11204f07-c6be-440e-9e72-ae2121b4cb66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:bfb8ef0c-a8f7-4863-a103-692ad9efd97b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P21917"}
{"id":"5bee460d-d2af-4beb-9ef2-06168114af60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2296132","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:8858ebb6-fe1d-45d7-bfdb-5d4b33c0e576","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6399","original_object":"UniProtKB:P31424"}
{"id":"d47a58fb-4b08-4b4b-9733-00f7d970e6b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817437","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:7592476f-f079-4919-b3aa-215aa46d67bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2268","original_object":"UniProtKB:P41586"}
{"id":"485c93ae-6031-4493-a955-588a2082758b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:22068","sources":[{"id":"urn:uuid:f6c7e1fd-e95f-41f9-9572-2dd98cdf695d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q61143"}
{"id":"3696c91f-b795-43f7-9684-33e7fc0cd3b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49662","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:71f7c817-57da-4d64-8998-6afc6894b0e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1909","original_object":"UniProtKB:P23219"}
{"id":"a2716b26-e19a-4d1d-8235-ea939726ab94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:3ca0675f-a2ef-478d-b991-aa5978403421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q15413"}
{"id":"712fa02b-2a94-4b69-a4ed-35ef36b369ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132268","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:07ff6b40-c347-4bb7-9610-43443191b55c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7422","original_object":"UniProtKB:Q15303"}
{"id":"a65b4794-d7b1-4869-b574-cdd0ada02559","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17659","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:b9778793-64bd-41ef-b335-6981a9380b4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1749","original_object":"UniProtKB:Q13304"}
{"id":"16f6d865-1d91-45e8-a5f6-81a0e3dd01eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67RM91WDHQ","predicate":"biolink:affects","object":"NCBIGene:10769","sources":[{"id":"urn:uuid:58392545-40e7-4cc4-97b8-d0e762e1c76b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7918","original_object":"UniProtKB:Q9NYY3"}
{"id":"56a9b18d-7f33-42a7-be6a-5e32d062cde6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92444","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:96ac9b04-78f1-438d-9a95-f4958b6fad19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:283","original_object":"UniProtKB:P34969"}
{"id":"bffa2bde-cf70-47fa-aa4d-04da05ffe0e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5053","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:94f7c4c7-f407-46a5-9280-6b7afeb9cb5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5053","original_object":"UniProtKB:P16066"}
{"id":"1cbb2576-e662-4963-8546-8af030a20c10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80003","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:ed5dc182-9d7e-4d5a-a554-97454f1bb46b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2744","original_object":"UniProtKB:Q96RI1"}
{"id":"b19b5e50-cb2c-4f11-865b-e786a7b9adac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164682","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:161bc5c4-e12d-4f7c-a4f5-9b42400232cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:146","original_object":"UniProtKB:P28566"}
{"id":"4320605a-26d0-4c2b-a595-b116a8bfd3bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:6ea80fe8-c238-4dfb-adf5-0a11f9ab4405","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P32745"}
{"id":"54ee0009-4d95-40a3-a9ed-e67c946754bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12312","predicate":"biolink:affects","object":"NCBIGene:6403","sources":[{"id":"urn:uuid:5d6eac0e-ae1c-432e-853f-54541657ce0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12312","original_object":"UniProtKB:P16109"}
{"id":"2aa56cb5-6cf0-4b98-bcfe-620a63ff7a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080966","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:d1401068-5689-4228-be8c-1efd770377dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2236","original_object":"UniProtKB:P30518"}
{"id":"5483f3ac-26e1-4ede-8df5-7e45182fd9f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25227633","predicate":"biolink:affects","object":"NCBIGene:10988","sources":[{"id":"urn:uuid:6dd568e8-fb01-4c34-a42a-b3aa83af4a61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6486","original_object":"UniProtKB:P50579"}
{"id":"e4d1ba16-74ca-410b-b164-a16c18eb8088","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:581F7DFA9B","predicate":"biolink:affects","object":"NCBIGene:57302","sources":[{"id":"urn:uuid:0832b59a-f834-40b8-8f38-bcf3ccd8d0e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10058","original_object":"UniProtKB:Q9QZN9"}
{"id":"abe2d4cd-92ec-45b9-8010-e1929009a901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:7616022b-0f89-40b1-b6ce-27f131f11ec7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:P32745"}
{"id":"21092297-c77d-4ad8-978d-830cd020f88f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3223","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:a9b43c0a-8184-4088-802d-7b716bd67b49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:36","original_object":"UniProtKB:P08908"}
{"id":"f0151e1e-d56e-48c6-969b-ea0625eff713","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:9256432e-ac0d-4434-b4fd-134cf356b80f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P35462"}
{"id":"bfad515a-0648-4761-8c84-6842a6cb9d61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566764","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:2a0cd59d-0836-40a3-af98-6dc43091d756","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8468","original_object":"UniProtKB:P09874"}
{"id":"db0fe941-4813-48f7-8f5c-3b3236dedb30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1111","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:9ab1c9ec-001b-431d-94fb-0cf6b38e127f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1111","original_object":"UniProtKB:Q02644"}
{"id":"8d422f97-4da7-42d1-bea9-f1ab72c2653a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60782","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:78594712-9d1a-4cf3-b44a-f8294dee29b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1940","original_object":"UniProtKB:P43117"}
{"id":"11235b63-1c69-44ec-a38c-33ed55de4fbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10324","predicate":"biolink:affects","object":"NCBIGene:8324","sources":[{"id":"urn:uuid:ba735bda-9896-49ec-bd9e-29c9dbdc7309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10324","original_object":"UniProtKB:O75084"}
{"id":"42498afe-7f77-4bc8-b456-3834d61304a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:f657403e-1065-4bba-97d5-b8876bd57c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:P35498"}
{"id":"9c62d74a-5505-4cd8-b737-6482b95f4794","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2112","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:03b6c236-e792-413f-94a5-14bf77a0c984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2112","original_object":"UniProtKB:P21452"}
{"id":"d6af6dae-6e19-433a-b182-c1e4a6e1047b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1544","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:4aece2bc-a10e-487f-9cb0-a5219d1d6591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1544","original_object":"UniProtKB:Q9ERC0"}
{"id":"cfb15b55-1729-4faf-87dc-2375d43f6fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:170847","sources":[{"id":"urn:uuid:b308bef4-6b19-4e2c-bc52-568d723ae197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q91ZF1"}
{"id":"ec62c2be-efdf-407e-b7f0-1299840af6b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U4Y54D5P9L","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:e38d874f-3ffe-413d-b725-3b5d4f1d4c1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3997","original_object":"UniProtKB:P36544"}
{"id":"0c951f47-e2a4-44b2-a130-1bc10359b4da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132837","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:70536efa-0182-4f66-9154-0641541f1a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9461","original_object":"UniProtKB:P25103"}
{"id":"f15653f1-1673-45d9-9a1f-05e94b463fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71565985","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:1126b035-1903-4ae6-9797-1fabe628a9c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11102","original_object":"UniProtKB:Q07817"}
{"id":"c839d072-5491-4e43-9116-b028d1634e2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17688","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:fda936b4-f2bf-4fa3-aa2e-0d2877e7a4fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2585","original_object":"UniProtKB:P32297"}
{"id":"cb94db12-3699-4988-bd31-2b913c06aaa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:458d978f-34f2-4ba4-9c8d-c094bfc9735e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q9UGI6"}
{"id":"d1c0cb9d-bbfc-444f-9218-b1102d3b1644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803245","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:ea9a864e-0b4c-4c2b-abc4-2722aafaca4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:339","original_object":"UniProtKB:P08173"}
{"id":"46308dbb-0d58-4a7b-adfc-2f7e4575a4c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:f2af8c9a-4fe7-422e-be8f-9466006cf362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P30966"}
{"id":"0cbdbe07-28d3-4945-8540-ea449a94525a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J45910S3X","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:c76fc80e-efca-445e-a765-c8ff8df2f3b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10314","original_object":"UniProtKB:P04629"}
{"id":"9157ce1b-23ab-403b-bdd1-a1ccdb64ef90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176744","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:1a97e32d-d740-4e4a-8d28-51af3e7dd6eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1925","original_object":"UniProtKB:Q62053"}
{"id":"ea7a871f-b55d-4484-8e7b-dbe42f9bfdc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6P06977L1A","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:720c3364-53a0-4273-aaba-3f3f69c6df7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2676","original_object":"UniProtKB:Q07869"}
{"id":"20652bc4-c010-4259-b426-1180898821f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66561167","predicate":"biolink:affects","object":"NCBIGene:85366","sources":[{"id":"urn:uuid:3abb6380-8a5d-487a-b3d8-9ea1ed6e5ecf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6740","original_object":"UniProtKB:Q9H1R3"}
{"id":"e51ed997-a5cc-4dd8-b2cf-0d429b738462","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10104167","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:7daf220e-4481-4b25-904f-61b232ebae09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6937","original_object":"UniProtKB:P08173"}
{"id":"0efa7490-b5db-41d4-9899-341b4f98e10d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10287730","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:039bdaee-bcf6-4fbc-be9a-cb0f831120b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:77","original_object":"UniProtKB:P28221"}
{"id":"1e14b27c-2c4d-4116-af20-7622df2f1fba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N33070GI64","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:a5cf8e0f-f211-4953-8692-7dfe23b53ebc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5618","original_object":"UniProtKB:P29275"}
{"id":"93553f62-f9c2-4fc9-ac9f-c0f2c9965bcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UMD7G2653W","predicate":"biolink:affects","object":"NCBIGene:83791","sources":[{"id":"urn:uuid:574a63ee-a092-4993-a1e9-619d3d079152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3059","original_object":"UniProtKB:P05369"}
{"id":"18798dd0-c4e9-4420-b966-da68751352f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5HNG5UF2U","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:d0194ab9-1e05-4938-bbb8-fbcb3948261e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11885","original_object":"UniProtKB:Q00535"}
{"id":"ff262bb6-5329-4fa9-a0ab-36440207ff08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2855","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:f5dcfd07-c278-49a6-bfef-2e9bdab5833e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5531","original_object":"UniProtKB:Q96LB1"}
{"id":"6c3de2fd-cf2a-4873-97f4-2fe70e2a6431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438780","predicate":"biolink:affects","object":"NCBIGene:81681","sources":[{"id":"urn:uuid:06b486dd-f5d5-4ae2-8320-10055ae24e2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6719","original_object":"UniProtKB:P48450"}
{"id":"46bd7404-3c04-477c-a012-1aa4f609332d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3709","sources":[{"id":"urn:uuid:8317f228-b792-448f-86ae-72108bf8eab4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q14571"}
{"id":"9ae01b64-c55e-4d01-90be-e69b9e0fc80a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46927297","predicate":"biolink:affects","object":"NCBIGene:64840","sources":[{"id":"urn:uuid:0b8412b0-7c45-43c2-b083-6723f1af54a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11166","original_object":"UniProtKB:Q9H237"}
{"id":"0cd735c6-118d-4431-a0fa-9730f0fd4890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946906","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:04b15ebb-c264-405a-b4e0-4be74627df08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12413","original_object":"UniProtKB:O08725"}
{"id":"0462196f-5093-4c03-8f43-d0746684c18d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7949","predicate":"biolink:affects","object":"NCBIGene:27330","sources":[{"id":"urn:uuid:8ddb0005-e404-4b13-84fb-89381716dc23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7949","original_object":"UniProtKB:Q9UK32"}
{"id":"ab856209-f3f5-4347-bde3-ec0ca766ecce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EF8081AQ6G","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:956607e6-d1cb-49a9-9c44-1f549eb5affe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9474","original_object":"UniProtKB:P41180"}
{"id":"a0bd8da9-35bc-4b97-aeeb-24e154d26355","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:4ce8f7d1-25b4-4420-a7e4-ebf2e1258374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P32304"}
{"id":"db4173dd-3f5c-4208-adaf-f9e6ffa01ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:378807","sources":[{"id":"urn:uuid:b6aefbb8-4986-44e1-a1aa-7065b2a41d6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q7RTX7"}
{"id":"2d365c61-6167-41b0-97cc-15b40efa04de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C88817F47Y","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:5d13891e-3cfb-49ab-b1a2-86597f711f6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8918","original_object":"UniProtKB:P42345"}
{"id":"fd0ad27f-1cd7-4f3e-bfa3-3903fe7b6955","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324620","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:82ac4556-96ea-462f-b2d2-4ccfe9e590cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:262","original_object":"UniProtKB:P50406"}
{"id":"04267836-36f1-48f8-b6d8-45bccba0132a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6538","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:ccabca05-b21e-4b6e-b56d-793801cdc1eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7216","original_object":"UniProtKB:Q9Y5S1"}
{"id":"3d0403f4-1d8e-4918-a402-dd09afe0b4e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3C6FZ6UXC8","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:55e7e79a-80a9-460a-916e-9ddbcb67eda8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7362","original_object":"UniProtKB:P41145"}
{"id":"2afaca6c-7daa-4cf6-bc94-9324a86e365b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993643","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:601f9182-df49-42a1-b618-ba02577557cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12486","original_object":"UniProtKB:P08912"}
{"id":"2f1b07fb-ff68-4899-b6a0-c58da9c5dff3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41633","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:f5377913-2686-434b-ad0f-c372ba1d881e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2751","original_object":"UniProtKB:P55055"}
{"id":"bdab6259-1db0-4345-9596-245bc3fcda21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92566","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:5fd52688-9939-4323-951b-35325dc1ac1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:122","original_object":"UniProtKB:P28222"}
{"id":"8c2941d8-15b4-4450-86b9-848d8a1ad725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6146","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:631fe2c5-4f8d-4d97-8711-5223fbedef52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6146","original_object":"UniProtKB:O88626"}
{"id":"1b8bd30a-e392-4eaa-96d8-bba8be0cca7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86673884","predicate":"biolink:affects","object":"NCBIGene:1675","sources":[{"id":"urn:uuid:980ce05e-7b59-40c8-b542-d6ccf8798ec0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11282","original_object":"UniProtKB:P00746"}
{"id":"1b0ed027-e02a-490b-9bd3-c2eb6b73c134","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9622","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:556df55a-58d9-4c1b-a068-1e6bb0be6610","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:360","original_object":"UniProtKB:P08173"}
{"id":"a64c6020-3ea9-48ca-8bbe-e283217fa6c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64310","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:bbb8affd-129b-4235-a7bb-2a1eceed7a0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4903","original_object":"UniProtKB:Q9UM73"}
{"id":"4209b6d0-4502-4d58-b743-b14479016699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131512","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:c0bc33e9-61d9-4781-b30c-05f2aa814222","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5281","original_object":"UniProtKB:O60341"}
{"id":"264ee577-7d61-4709-b698-cedd8a193ab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:55300","sources":[{"id":"urn:uuid:1d3cb55a-cb37-4ff5-8939-8ae4de6952a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:Q8TCG2"}
{"id":"e85e3e24-a13a-44eb-9c33-fa5ed5fa1d01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28544","predicate":"biolink:affects","object":"NCBIGene:476","sources":[{"id":"urn:uuid:35fe8a69-aaca-44a2-bde2-15737620fa6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6782","original_object":"UniProtKB:P05023"}
{"id":"d91d2c6e-0f15-4e0f-ac76-d5124cccc537","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12843","predicate":"biolink:affects","object":"NCBIGene:404194","sources":[{"id":"urn:uuid:e779b0a9-8e42-4f5c-a069-7daaef16fa35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12843","original_object":"UniProtKB:Q6SJE0"}
{"id":"516841ea-f21a-4a69-ae01-949d244e6c5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135355941","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:c2e028ee-6a4c-451d-9f7c-0a0654d42e52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11791","original_object":"UniProtKB:P51813"}
{"id":"14477c3a-40c9-450e-8b63-256fd85cdc96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:b4b2df91-6620-4104-a0e1-eab0efae81bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:P35346"}
{"id":"eacb21a3-fab2-4bd2-8cc9-66ec2c607194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755240","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:f9ff64c0-b5fb-405c-8678-68de6e4dd763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6731","original_object":"UniProtKB:P17764"}
{"id":"2c85d1c0-10b5-482c-b718-23976d000085","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25262525","predicate":"biolink:affects","object":"NCBIGene:26191","sources":[{"id":"urn:uuid:59edee59-b1b3-4dea-82c8-be0eccb4194d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10374","original_object":"UniProtKB:Q9Y2R2"}
{"id":"15bea08d-a498-4e93-8baa-89590cab23d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:e2b9e594-b605-483e-b02c-3cd11b44407f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:Q5S007"}
{"id":"4216175c-f80e-44fb-9aef-4bd0c6e2afe4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57330144","predicate":"biolink:affects","object":"NCBIGene:85397","sources":[{"id":"urn:uuid:a0406a00-7fc2-4758-bc42-1b93cbe7df1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8034","original_object":"UniProtKB:P57771"}
{"id":"0b9a3001-fda9-42b2-a1de-64bce2c2b05b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71529770","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:d1845583-f540-450c-b4cd-b99fa59b8783","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8166","original_object":"UniProtKB:Q9Y463"}
{"id":"47fc7d13-8aa7-451c-a0fb-e80bf63f60ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643961","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:27fdc591-cc40-4bc5-ba4b-41af0f9ba391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2794","original_object":"UniProtKB:Q8NHX9"}
{"id":"19bd6573-44c6-4010-ad1c-258da4b309d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:853085","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:33307d6f-cba8-4e67-8f53-210156570aa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13557","original_object":"UniProtKB:Q8TDS4"}
{"id":"d58bbbf5-5b00-4c1e-854e-b16d6184991c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53358901","predicate":"biolink:affects","object":"NCBIGene:408199","sources":[{"id":"urn:uuid:8f95b6b0-dcb3-462b-901b-dd16f7637523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5514","original_object":"UniProtKB:Q6IYF9"}
{"id":"014e4498-6a3f-4d3d-ac71-ae1acb2f1983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63681","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:cb3268c7-fcd0-42bb-b309-f4140fb3403c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4252","original_object":"UniProtKB:P30542"}
{"id":"30854f0f-99f3-41c2-8959-dfcb11c2d87c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93519","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:f55f0ee0-fca0-4751-b7d6-7ac29b7eb9bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:187","original_object":"UniProtKB:P28335"}
{"id":"9a6d39ef-196c-452b-ac9c-dc2f75afd9b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91419","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:53596d25-0f15-4fde-a7a0-305d665a5d60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8473","original_object":"UniProtKB:P06493"}
{"id":"e3fac08c-47b1-4fc1-846c-be94720c34f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:158348","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:eeed56aa-88e5-444e-8e38-cf03e54309fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2234","original_object":"UniProtKB:P30518"}
{"id":"fd622b5f-f2df-468a-8d50-5a8603930d1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2316","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:68741b57-0baf-4e06-abe2-7e3ace248279","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2316","original_object":"UniProtKB:Q9H2S1"}
{"id":"71b5e407-c2b1-4195-8bc5-7e24ba7d0961","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1290","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:d7570b0c-bfdf-4586-9825-60f54b863c3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1290","original_object":"UniProtKB:Q969V1"}
{"id":"fdf8d0fe-368e-405d-a187-7820d611177d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232985","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:a9e99c8e-6189-4f56-88b0-02038ff95908","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2318","original_object":"UniProtKB:Q923J1"}
{"id":"428408c8-f504-4f63-8f91-1ccb7e6163f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:de7ffc1e-dd2b-454f-96d6-d9c23e0800a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P30994"}
{"id":"70a998b9-189a-4041-aaab-8d4272a42544","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"UniProtKB:Q61618","sources":[{"id":"urn:uuid:fed6439b-b1b1-406c-b2a9-3943bb97262c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:Q61618"}
{"id":"9341af4e-09a0-4feb-8db2-8c6da2623c03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2875918","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:dc964618-e0a1-4c6d-960e-a735284b424a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3318","original_object":"UniProtKB:Q8TDV5"}
{"id":"7aa61cbe-dd06-429e-b17a-315983adee52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129897070","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:c1a61431-81a3-4599-b631-fc0dfcc8544f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13561","original_object":"UniProtKB:Q5XXA6"}
{"id":"1b2ee0e4-d67b-4085-a9bf-9b9f295502b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7986","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:ecf7363d-33ca-4db6-b053-5b0f37c5ab84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7095","original_object":"UniProtKB:P29275"}
{"id":"fe213bfe-87ac-4b70-bdb4-d49ad8a96996","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130961","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:64cebe4f-75c4-420c-8579-baa433b6838d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2005","original_object":"UniProtKB:P30872"}
{"id":"d29aaa56-e9da-4787-9fdc-31a7cdb3883f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28445","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:e95bd415-1be7-44ae-bf54-022ef29b57fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6785","original_object":"UniProtKB:P07437"}
{"id":"b516bdb3-a57d-4616-9469-fb7b50747ebb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947069","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:e453b1ce-0ceb-43af-9585-f5d7b68a46d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3216","original_object":"UniProtKB:Q03426"}
{"id":"42690652-7df8-4ed9-8340-fb7deab2dbbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131490","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:1998b9f7-3690-4261-95b9-bc5f7c622b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8018","original_object":"UniProtKB:P49841"}
{"id":"5cfcc407-2e01-4931-8fd1-6aa05620b9a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44132853","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:90f478dc-84ed-4329-88ec-10eee55528ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9814","original_object":"UniProtKB:P04049"}
{"id":"a89b165a-b17f-42f6-9de1-c4daf177529c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64055","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:e19148fa-53a5-4338-b744-9b96fe4e5435","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:109","original_object":"UniProtKB:P28335"}
{"id":"46b69101-70b0-4c70-8f06-ce17d4283a71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MZK2GP0RHK","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:c3559d5e-6651-4379-b5c9-9721465d9e9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8309","original_object":"UniProtKB:O60674"}
{"id":"db66e5f9-6005-48e4-be97-e3ca5374e058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76IND1BS43","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:b8acf9a6-755d-4863-954d-5c40abce9205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4154","original_object":"UniProtKB:O15399"}
{"id":"c969b1d4-c847-4128-88dc-3eef64def835","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13168","predicate":"biolink:affects","object":"NCBIGene:11173","sources":[{"id":"urn:uuid:353510e6-0ad1-4e01-87a5-ef6118a80774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13168","original_object":"UniProtKB:Q9UKP4"}
{"id":"118c3d56-a36d-4357-a70c-0e7bc136fb26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80312","predicate":"biolink:affects","object":"NCBIGene:21338","sources":[{"id":"urn:uuid:3d62c01b-59c8-4bec-88dd-031028a1dd6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2090","original_object":"UniProtKB:P47937"}
{"id":"e25cbbd7-c3aa-4f09-8d1d-5ae7cdd7f038","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135138454","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:e179f6d1-1eb9-4459-a23b-02ff15af80d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10698","original_object":"UniProtKB:Q7Z2W7"}
{"id":"ff7ff362-ea3f-45b2-bd15-400480dd7b3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:4d780c27-237f-4eaa-9d21-b04610a7bdf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P28335"}
{"id":"993dfba5-63f9-45e8-84b3-4ec52e981c04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180876","predicate":"biolink:affects","object":"NCBIGene:25327","sources":[{"id":"urn:uuid:b648bd90-f23c-4eb4-a10c-7c604109a66c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:208","original_object":"UniProtKB:P25122"}
{"id":"f183df7f-dd6b-4c23-a4e0-2e8f56880798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321165","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:339d6790-9351-414d-8d05-8e6c7e0ab60a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10185","original_object":"UniProtKB:P41143"}
{"id":"9483fda0-096f-4fb1-9692-3213ee961d16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121990","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:6ef8ec31-2982-4f30-bb02-44048a7e4167","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1763","original_object":"UniProtKB:P47900"}
{"id":"6edb4fe4-a0e7-48c6-9099-9400229724ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4T36H88UA7","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:f6f23d9b-1b27-4319-ad9b-084c5c0424ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9043","original_object":"UniProtKB:P10275"}
{"id":"e47a8e00-d381-4fa9-8b53-3353071b8289","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11278","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:45a0d422-c9f9-4759-8fa6-9a71913e1d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11278","original_object":"UniProtKB:P21802"}
{"id":"967fb888-6a63-4579-9911-1b88f5ed1411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146014436","predicate":"biolink:affects","object":"NCBIGene:3760","sources":[{"id":"urn:uuid:dacfcebd-0a2b-483f-a1dd-2ce2710e8517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10260","original_object":"UniProtKB:P48549"}
{"id":"f58d1734-c4e1-4660-9469-55823d8deb37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90936","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:846f9235-aa9e-436c-8482-be61bc9a3531","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7739","original_object":"UniProtKB:P08581"}
{"id":"11bb17d7-dd3f-47eb-8ccb-c757d5904979","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2MK663C346","predicate":"biolink:affects","object":"NCBIGene:25245","sources":[{"id":"urn:uuid:42592f7f-0c89-4410-9e1e-fec88f385d40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:672","original_object":"UniProtKB:P25023"}
{"id":"44215314-718b-4bdb-8eb7-07555c5e5c68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8633","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:73fdd883-01d8-4397-a6d8-86c84d41f371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12553","original_object":"UniProtKB:Q9HBA0"}
{"id":"33130f7f-6874-492d-b52d-ac8542c51254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83766","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:c9956787-fb90-478b-a815-38d9269d4142","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7519","original_object":"UniProtKB:Q9UGN5"}
{"id":"50a84409-afd1-49bd-989c-e1dfa9692219","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:2444","sources":[{"id":"urn:uuid:6fcb068b-6e56-4ef1-bba0-d23d76633a68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P42685"}
{"id":"85a234fe-58b3-4562-a6e1-d0ad0e47e209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10427006","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:799a5167-84ca-4f45-b1f7-afed04f8cab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5235","original_object":"UniProtKB:O00519"}
{"id":"3d17e303-089f-4f3e-9dff-c188eef098e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3975","predicate":"biolink:affects","object":"NCBIGene:8973","sources":[{"id":"urn:uuid:c0a4ba35-0ac6-46dc-84bd-c4dbdd43bb60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3975","original_object":"UniProtKB:Q15825"}
{"id":"fb7dd4e3-1a83-48a7-b6b9-8d2d1f0875bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16980","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:5837a141-4dba-4548-a9e6-9eddc17f6118","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6327","original_object":"UniProtKB:Q8K424"}
{"id":"b8d219cf-6972-46c1-80cc-e846fcd69ac2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755024","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:f420dd66-fdee-4ea8-aad3-01180e8d7b24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1982","original_object":"UniProtKB:P21731"}
{"id":"44b341d3-a135-4a09-950a-29623fbf775e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2541","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:d97e637c-d091-4b6a-822b-5241d4f0295c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2541","original_object":"UniProtKB:Q07652"}
{"id":"2a85945c-95d2-4847-b8bc-3e440997dba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23786499","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:474d0ee4-50b5-4359-aebf-090d3ab0f4a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1194","original_object":"UniProtKB:P35367"}
{"id":"71416932-e2fd-4e1a-a887-c2fe07c8f3c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93368","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:1e1be2ad-df42-4709-ad3d-a8f51d3fcf55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:173","original_object":"UniProtKB:P28223"}
{"id":"b7957b41-98bc-4311-850f-0f95d5ce6b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81527","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:4072a0c6-125f-4f12-af2d-d401cdf0be73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1631","original_object":"UniProtKB:P42866"}
{"id":"d4dfb3d0-c926-47d7-8f88-5a63cf57648f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6413","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:87a23405-3502-4aa8-adbe-38fa8a74c13b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5209","original_object":"UniProtKB:P11511"}
{"id":"77097ad0-b6e4-4916-88fc-9c0c641d091d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311186","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:faf722cf-cd04-4a7e-94e4-0c85b0e6cadc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1266","original_object":"UniProtKB:Q9Y5N1"}
{"id":"b69aa22d-0e0a-446b-b842-74d869503df8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2814","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:9a7350e2-c868-4f75-b6fb-7d0a23dc46ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:296","original_object":"UniProtKB:P08173"}
{"id":"d6878091-a341-4736-ab17-3bb8e058c49f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60148519","predicate":"biolink:affects","object":"NCBIGene:8722","sources":[{"id":"urn:uuid:eea9de79-22c2-4337-b423-2fc21d81b4b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6535","original_object":"UniProtKB:Q9UBX1"}
{"id":"9e360019-1355-4a2d-aacb-407c2f74eb4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10316032","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:c78422d4-aa54-4ba4-9aad-2428354afc56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8246","original_object":"UniProtKB:P36897"}
{"id":"deeeb06d-831e-49a5-9fbd-7e754f8b21ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65326","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:b58485bb-fc69-4b89-9b40-a5cb8b186e61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5682","original_object":"UniProtKB:P42338"}
{"id":"71ac88b3-4c33-4c6f-95bf-d26ced188f7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:d4971415-b5c8-4f0d-ad73-ab25e874884d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P43115"}
{"id":"4e7b6f57-e745-4b24-b4f3-f9ae04d04b04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155753054","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:35db9d5d-9878-4cf5-b535-3ded09ae63a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11880","original_object":"UniProtKB:P04629"}
{"id":"8128967e-c851-431c-bc29-0d3d0d503c4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:753b4048-cd99-4721-aa22-3dacd5ba2429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P32745"}
{"id":"217c8b37-2262-448f-aa8b-a796bed3601a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11624321","predicate":"biolink:affects","object":"NCBIGene:79239","sources":[{"id":"urn:uuid:d0470889-d6fc-4f32-9580-c7f0289343d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8873","original_object":"UniProtKB:P23711"}
{"id":"69af2a98-b8e5-4508-919a-c5bb3df10b74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2050","sources":[{"id":"urn:uuid:e3d387c8-27f8-4cd2-b2fa-5fa1dc379b18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P54760"}
{"id":"eaea5de5-a52d-4761-8e28-64b034239b11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8410","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:eed4acdd-1275-46a0-9e0d-8ba1dc17a88a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8410","original_object":"UniProtKB:P32239"}
{"id":"717dee0d-1fdb-49cc-997e-a6eea2e7990b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:a1d56e91-8ae3-4c19-940a-e8fe684e1107","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:Q9BWU1"}
{"id":"e8e076a3-bbd9-4884-9b27-d5f9d3e268dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132787","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:210ee3f4-704c-4d3b-a5cf-b1cdce7b14d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:26","original_object":"UniProtKB:P08908"}
{"id":"97f97ebf-781c-4431-b5e5-9ed77257f827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:0558001c-dace-4fc2-822d-598b706174cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P08908"}
{"id":"787452a1-7d08-475d-9d9e-22852391ab69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:8001903","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:cf2a11cf-cc07-435b-b989-c20b3c8697b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10034","original_object":"UniProtKB:P55055"}
{"id":"ff68b1a9-73f1-4322-a22b-2d2c9f020b92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:9a681916-23cc-468e-aed4-711ef70e9c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:O88854"}
{"id":"3e947dac-373f-4ea1-b21f-54260a3c2639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:918","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:32c3636a-c328-42cb-94de-957d2ca8f61e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:918","original_object":"UniProtKB:P34998"}
{"id":"14f9f0fc-cb8c-474f-aeba-fa87fd517af5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16039","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:f3481cfe-289a-48ef-bcfd-01128185d657","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1743","original_object":"UniProtKB:P51582"}
{"id":"3d3c91b1-836d-4ba4-8595-2a82f5372508","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:2e5cc9fa-92eb-45a0-adc5-5162b6450457","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8593","original_object":"UniProtKB:P20309"}
{"id":"5a02d43d-73da-4fa2-b972-8c09e58045a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081973","predicate":"biolink:affects","object":"NCBIGene:50506","sources":[{"id":"urn:uuid:9bc823c5-822d-4aef-a8a4-10c9393ec25f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9933","original_object":"UniProtKB:Q9NRD8"}
{"id":"8749a2d1-40f0-4d5f-8bc2-ce4680b1c3c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321155","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:9127106f-32bd-4b14-8192-4c6265857f5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10147","original_object":"UniProtKB:P52333"}
{"id":"ee03658e-4b78-4567-822e-1593dbaf638d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:051ff956-24bf-4122-ae60-40b67af11ae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P41595"}
{"id":"5d34253c-bc1e-4bb3-895b-b3ec7ca71352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YD43M7UAP4","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:8b12fb71-df42-48a5-b77b-df24b2618c77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3196","original_object":"UniProtKB:O95749"}
{"id":"ce94e590-6ff8-4e58-b5bd-b5ff539bec68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11449","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:a384252b-bb7c-4ba2-9fe9-74afb5f9288f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11449","original_object":"UniProtKB:O43614"}
{"id":"ed11fb59-75f9-4d08-93ce-ad5eac2c7256","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131358","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:f73a50e0-7ecd-4e5f-8210-5a62cabb6a4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3289","original_object":"UniProtKB:P29275"}
{"id":"88215ac1-b394-4923-a879-64f51234b59a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611889","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:9d17e6df-10bd-483a-b04c-25fb4519869c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9970","original_object":"UniProtKB:O60885"}
{"id":"03c08950-ea8c-48ac-b262-9b18fde9082c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58525066","predicate":"biolink:affects","object":"NCBIGene:8576","sources":[{"id":"urn:uuid:03ca7632-4bea-40cd-9218-f9c1df510d7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9692","original_object":"UniProtKB:O75716"}
{"id":"1c920306-37f5-47df-93a7-115789970eea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34468","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:0c3fccb7-7403-4065-8569-717d4078c239","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4081","original_object":"UniProtKB:P42261"}
{"id":"da8bbcab-3d28-41fa-ac30-2445bbf9f11b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801163","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:1dea11ef-12ad-42a2-b78e-a718b714b4e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9712","original_object":"UniProtKB:P36888"}
{"id":"bba2c038-476b-4fc2-b0d5-c80b0c13fd14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57928403","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:14bfc0ea-d0a8-407c-92c6-45f52523360e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8315","original_object":"UniProtKB:P23458"}
{"id":"14fea927-fc2d-4e1e-862c-b4303ebb2faa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:13dff45d-5a93-4a78-84d3-a59e8213ddd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P35968"}
{"id":"c716774f-579b-4aba-bdcd-357c043b9f70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10324989","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:8fbbe855-b2a5-4d2a-b18a-afdf74ef2174","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9799","original_object":"UniProtKB:P21554"}
{"id":"776c56ba-fd0a-4c96-916c-e4f53751a2e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32058","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:7e7c5e95-7842-4d18-a988-288330f126e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:893","original_object":"UniProtKB:P30551"}
{"id":"dff22f69-f0b4-4c1a-a806-dad2966bb487","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16469","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:cc784e79-e6f4-4015-85a7-3717922bc501","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1013","original_object":"UniProtKB:Q12791"}
{"id":"dae36ba8-10ff-428d-9020-e0ddeb0283cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:2fd89e04-e803-42c9-8a0c-9752c56801c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P25100"}
{"id":"6243b68d-85aa-4032-b7e8-647ab4e1b03c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77936","predicate":"biolink:affects","object":"NCBIGene:31","sources":[{"id":"urn:uuid:25e7857c-f3ee-4e34-a809-2692cad54b3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5280","original_object":"UniProtKB:Q13085"}
{"id":"a027183d-7436-4c20-88c3-35654a05fd92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D26C95A960","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:3ac480af-4ebf-453a-b9d4-d06ab4d632e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13129","original_object":"UniProtKB:P18825"}
{"id":"1ef3d9f6-a4e3-42d6-b541-c9a39474af74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41922","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:2e81c64c-8000-4b8d-aca2-03bfe9ca6cb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2801","original_object":"UniProtKB:P03372"}
{"id":"8e666263-fb43-4173-b171-9842417e6cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:20f5fb8f-3b77-47ff-8f8d-72b547fd66ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P35375"}
{"id":"bcdf0576-ffb8-454b-a72e-1b886ff836d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16172435","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:8b588b4e-41c2-4f5a-ab58-925ca34016d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:991","original_object":"UniProtKB:P24530"}
{"id":"87bfbd68-54da-42a5-8a0b-d081e8fbab1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28125","predicate":"biolink:affects","object":"NCBIGene:20181","sources":[{"id":"urn:uuid:1d846c14-c797-40e6-aad9-170547ed0e70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1051","original_object":"UniProtKB:P28700"}
{"id":"30b8e145-3d59-47dd-ac64-fb12957ce819","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699440","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:9e18db20-02a8-43b4-9828-a9266e261ac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11083","original_object":"UniProtKB:Q99685"}
{"id":"9bec831d-33de-41df-9dc1-bc1bc3c6486a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5050","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:7f0c66e4-f742-43de-8357-09a41def6460","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4819","original_object":"UniProtKB:P35367"}
{"id":"da4cb608-672f-434e-be0e-87363dff965a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11614352","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:ee13688e-9277-485c-8d84-ea1ae7dc04f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7686","original_object":"UniProtKB:P51681"}
{"id":"d075887b-653f-4cdf-a7a3-22b4c0d06c39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11465","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:af75c8e7-8f38-4ba9-95cb-8169284efcf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11465","original_object":"UniProtKB:Q9NSD7"}
{"id":"dca5243e-3241-4fc0-bb2e-7169cd26401b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3330","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:411e019e-4f0a-40d3-a4fc-7758556de2ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11643","original_object":"UniProtKB:P43235"}
{"id":"494cc205-7638-4973-9db0-50cbfffdc663","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233402","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:9d816819-5468-4556-b945-88c76062b129","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11889","original_object":"UniProtKB:P00533"}
{"id":"d81f31dc-41ca-465d-96c6-792f5ecaeb6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CER0OPG92L","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:aa4162a7-99f0-4b17-81f7-5959216004ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10044","original_object":"UniProtKB:Q06187"}
{"id":"95846c7a-a6da-4ecd-b265-3c298478ded3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229220","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:4db84c8c-dcb3-46a4-abdb-4336003f608e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10316","original_object":"UniProtKB:Q16620"}
{"id":"cbc291c2-ab7d-4f3a-bff6-7bd25fa3f8cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:75b5361d-8636-4bff-aa5a-a26111312918","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P14416"}
{"id":"c261bbfd-b1bd-4546-a82a-b46ed14f8966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19023535","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:b711b7ae-c4c2-47d4-babe-d6aaa3514476","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:883","original_object":"UniProtKB:P30551"}
{"id":"062a3331-3ce4-4dc7-9641-1773e019544c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W71J4X250V","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:b8b2b96c-d4aa-4ec3-a46c-d1c339493522","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8382","original_object":"UniProtKB:P42345"}
{"id":"afea73da-0da8-402c-aa3c-5222101af451","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:16506","sources":[{"id":"urn:uuid:2abae382-b1a0-427a-9492-5a588ffa00ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q03719"}
{"id":"38c5c1a0-4d6e-4911-8117-1d89ef56b2ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:1af8b058-991a-4b11-893b-9913ddb1227c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1641","original_object":"UniProtKB:P32300"}
{"id":"f62c1218-ff13-43f6-9280-151e3cd26b95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3354","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:6984c131-443c-4a49-b0ed-bac48e591468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6491","original_object":"UniProtKB:P08473"}
{"id":"0a9ff6e6-f433-4727-b21a-16515c14ba4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92540","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:da00afeb-85e9-41e9-8c2e-ec4dceac8f09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5947","original_object":"UniProtKB:Q00535"}
{"id":"f5515079-1dd8-45c2-a1ec-c8d813371f65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947060","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:449030e7-8e76-4ed9-b5b3-c9bf8a28d88b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3129","original_object":"UniProtKB:Q02769"}
{"id":"958136ed-6e0c-42bc-9394-8753e4b4d0c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91936970","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:73818e91-6665-451f-bb19-6b9a207eaa6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9989","original_object":"UniProtKB:Q12852"}
{"id":"03ebada8-a273-4638-b24e-348ec3cfa4f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2261","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:b48e040c-0dd2-49e2-be8e-0675d223ccc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2261","original_object":"UniProtKB:P32241"}
{"id":"dc67af67-1778-408e-a9d6-96645c9f9fd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25125014","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:33c8eeb6-6d9c-4685-9ac7-0e84def54ea3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8176","original_object":"UniProtKB:P24941"}
{"id":"2a862fdc-bb59-4755-9061-982ee2afb272","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44915","predicate":"biolink:affects","object":"NCBIGene:63895","sources":[{"id":"urn:uuid:50b107c8-9f80-45b7-a017-42d4b6b72fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5464","original_object":"UniProtKB:Q9H5I5"}
{"id":"657bbdcd-d7ae-42b5-963e-47480fb9fd3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2052","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:db264f17-f6e8-456c-8b4e-eb1418e5c86f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2052","original_object":"UniProtKB:P30874"}
{"id":"15d5d005-96eb-486d-ae7c-7e33cf427e13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:211468","sources":[{"id":"urn:uuid:77b4acf8-7032-4824-89e6-36da6adc125e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:P59111"}
{"id":"5bc93ec7-1304-4726-997d-cf11ce08d5a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:9e6ed271-55a4-491b-8536-f3115f216ff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P14867"}
{"id":"f8d923cb-697d-4238-91d6-bb981aab1729","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131709240","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:b8988938-6fe9-4a90-b556-a7127dd2c36b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10117","original_object":"UniProtKB:Q15116"}
{"id":"3a50e1f0-633e-4502-b205-2294850243a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:6098","sources":[{"id":"urn:uuid:039570f3-8996-4b0e-9efd-49ccf0cf7a93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:P08922"}
{"id":"40ff09b6-5f04-437f-bd48-f29dcefd5c70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67CKV7X08G","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:d9c49bdf-04d9-4308-a6cc-d77f284a3871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5615","original_object":"UniProtKB:P30542"}
{"id":"d54ba364-cfd5-4f76-9387-8a489d0dbe59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4612B80545","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:6bbae4bc-9cb9-4648-87e2-7969da7477b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12747","original_object":"UniProtKB:P56817"}
{"id":"dff76cdc-2084-48d9-8448-c6a72f7df7a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3210","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:e877c2e8-07c4-4927-8928-15673379f3ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:144","original_object":"UniProtKB:P30966"}
{"id":"881ba952-a4ce-4c0f-8867-b85ee786606a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422745","predicate":"biolink:affects","object":"NCBIGene:2011","sources":[{"id":"urn:uuid:a2fbdb86-9549-4234-b841-7ad0ebfcd927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12936","original_object":"UniProtKB:Q7KZI7"}
{"id":"563af6a7-379d-46b3-b4bb-e75840b8180c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194186","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:ca99fff7-4ed9-4802-be5e-442b197824aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11429","original_object":"UniProtKB:P43220"}
{"id":"3c4cc27d-76f3-4a9e-8fb3-51c73b70ced6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:79f424e8-a144-4244-a2db-1306c0ef887e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P32305"}
{"id":"df2a002d-79bf-468f-af14-1aff58b8e003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755026","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:3b8cb116-e240-468b-b2c8-1f90cd755fe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2078","original_object":"UniProtKB:P31391"}
{"id":"5d640872-d2f0-4aca-a6b4-81a7808f6619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95340","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:c153e9f7-8501-41e9-bfdc-81ab3fd8f2b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11064","original_object":"UniProtKB:Q00535"}
{"id":"f96e4492-006a-4ebe-a433-eacf2283379d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1207","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:a4910579-0196-4f12-b9b8-1fc190e3fb55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4089","original_object":"UniProtKB:Q05586"}
{"id":"9f0250c6-ca80-4fcf-89ec-7275a46d1caa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25207521","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:fac44c07-bd19-46a7-bef9-19668b5948f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8163","original_object":"UniProtKB:Q15418"}
{"id":"0e69f737-5426-4f67-8e9d-c8387a02cf49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229230","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:9b4616b3-ca64-4da2-87b2-fd5e58d22727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9331","original_object":"UniProtKB:P21453"}
{"id":"944be814-45d0-4b02-9487-d5561e84c1e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z80293URPV","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:62554994-662a-4906-9452-8faaa77758f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8709","original_object":"UniProtKB:Q9H228"}
{"id":"e770097a-ecbf-4eb0-9486-df60f1f8d016","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O8E148Q90M","predicate":"biolink:affects","object":"NCBIGene:57302","sources":[{"id":"urn:uuid:352964eb-3629-4d58-8ac4-5ce21e3d4f27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12752","original_object":"UniProtKB:Q9QZN9"}
{"id":"310c87b9-b4c4-429c-9efa-ca133b30e7b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25269122","predicate":"biolink:affects","object":"NCBIGene:1571","sources":[{"id":"urn:uuid:0931f7a0-6746-47dc-9b28-6ecd61f6f311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11354","original_object":"UniProtKB:P05181"}
{"id":"ffc1ec34-e4ec-46fd-9ccc-1d8a34169208","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95340","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:5cef9c2c-bd1e-4d6e-8a01-2c4f6d663869","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11064","original_object":"UniProtKB:Q13627"}
{"id":"d83f5fe2-c867-449d-b34d-e28778778be5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:140914460","predicate":"biolink:affects","object":"NCBIGene:79723","sources":[{"id":"urn:uuid:eac59a45-fd7e-4aa1-a65f-98c9bf3f2564","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12664","original_object":"UniProtKB:Q9H5I1"}
{"id":"e2b21a98-7e68-474b-b715-29d3ede50ba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:681850","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:cdd11136-dc68-47e6-b2b8-32cb02817f3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2203","original_object":"UniProtKB:P37288"}
{"id":"5cbb9030-6c69-4d30-999e-da85aecc7aa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5193007","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:cb622286-8c7d-4435-a655-e879c36350a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5943","original_object":"UniProtKB:P50613"}
{"id":"e5feeb17-cde1-4fee-b91a-de1ddb13e12e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:7a890842-83bc-4475-9ea5-9cda15f47800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q9Z258"}
{"id":"0dd555bf-f2b2-4afb-96ff-da5321695565","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:142505495","predicate":"biolink:affects","object":"NCBIGene:9970","sources":[{"id":"urn:uuid:c8c1b5ed-6cc2-4aa7-b733-ed8f6825ca8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13871","original_object":"UniProtKB:Q14994"}
{"id":"ee0acf8b-ede7-417d-adfc-c586e226da99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:131096","sources":[{"id":"urn:uuid:d5bc8c96-7d68-496e-a4e2-8234b40c19df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2344","original_object":"UniProtKB:Q96L42"}
{"id":"08e0d7eb-11a7-48c3-9932-f0db900bc93f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:013d0c11-7862-4a17-90fb-b6b2833aba0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:Q9H228"}
{"id":"93e07bfc-fa91-46ca-aaf7-5affb58f2fb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82602","predicate":"biolink:affects","object":"NCBIGene:24310","sources":[{"id":"urn:uuid:f6314d51-f40b-491d-98ab-cf24b80360a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6463","original_object":"UniProtKB:P47820"}
{"id":"77c3dc15-49d0-48e5-affd-ea96de0d48dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:1613","sources":[{"id":"urn:uuid:ef67307e-c096-4c34-805f-2983d75c8588","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:O43293"}
{"id":"69215903-6e75-4152-a2b4-8d112b8b0da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:39f7b7c5-5c20-42e6-8a18-51f5d0f7fa1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2291","original_object":"UniProtKB:O75311"}
{"id":"ee0166b5-39a0-4e9b-b21d-abaefff50c6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90643548","predicate":"biolink:affects","object":"NCBIGene:5129","sources":[{"id":"urn:uuid:21e7e6a6-b96e-4be2-af42-a8093f5df736","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8217","original_object":"UniProtKB:Q07002"}
{"id":"53c34275-f563-44e7-98e4-7931ea1cab8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10436045","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:a3be1051-dfe1-45bf-ae4d-9013f6e0b2a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:782","original_object":"UniProtKB:P41597"}
{"id":"02c9447c-c7ff-4ae5-823b-6f828a611127","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:53a15ea3-3b5f-4b93-be5e-69b6c820539b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P08912"}
{"id":"edea5c83-91dc-4427-b1ba-1548254cf393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229762","predicate":"biolink:affects","object":"NCBIGene:7514","sources":[{"id":"urn:uuid:852d5459-5538-4ffb-9d08-206bd3ecfa30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10037","original_object":"UniProtKB:O14980"}
{"id":"4cc90bf7-db11-458e-8d36-a22022493dba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:1508","sources":[{"id":"urn:uuid:d35c39d7-1ebb-4933-a019-56e9ee5d3ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:P07858"}
{"id":"9693edbe-3d25-44ba-aee9-2fabd732f0be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7633","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:e74c8ed0-9db8-4413-bff2-72cefdeb0dab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1630","original_object":"UniProtKB:P41145"}
{"id":"589526ed-876b-4f86-8ce7-780f0ee0749d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134301","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:d1b60610-4831-4b69-bfec-ba039a33dba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13515","original_object":"UniProtKB:O60341"}
{"id":"687f242d-7913-4317-92de-033fa00b1467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131502","predicate":"biolink:affects","object":"NCBIGene:498475","sources":[{"id":"urn:uuid:a8583e13-7d39-435f-8adc-a7de7ccef763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1878","original_object":"UniProtKB:Q9R261"}
{"id":"5f27c65c-2cfa-49a4-9595-537b9b2ca103","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:246153","sources":[{"id":"urn:uuid:eee4919d-9ff2-4956-bd9c-94c1fb4c0530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P22462"}
{"id":"07d549bd-9e1d-472b-869d-817a92bfadee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52951677","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:ed804322-d290-451c-addd-34b849751cca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11707","original_object":"UniProtKB:Q6W5P4"}
{"id":"4c4db490-0e4a-4dfd-9c9c-ffb7c0aea146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:36033747-2184-4dd8-8b97-f6ab107f0305","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:P24941"}
{"id":"f415cc79-41df-4de3-8bf6-4ae7f0b6afd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44219611","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:2dc6ad90-6e7e-49d8-8ff9-e861047c5251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7030","original_object":"UniProtKB:Q86X55"}
{"id":"2c7aa6bb-a113-46b0-9886-3930087a9546","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:341abd9d-93f5-4182-9ec2-36146b51ae28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:O14649"}
{"id":"680200e9-c2d8-4109-92cc-db7a6c7a180a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:8b790ee7-44aa-4149-9ea5-b55068546d3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:O15379"}
{"id":"db0acce5-9ddc-4d1a-8a9b-df777659961f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44915","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:bb4e3b0c-2c57-4653-9eea-f7686b5e223d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5464","original_object":"UniProtKB:Q92508"}
{"id":"5f7e2774-7704-4dce-9771-105e7387e815","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310954","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:ba5d7a68-8e90-46a6-827a-c6a51fa3472d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1756","original_object":"UniProtKB:Q96G91"}
{"id":"da02968f-a861-4c9a-ad7b-560f3df25a09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:18ae076d-9702-4047-aabb-181302268c1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:Q92736"}
{"id":"47aee720-0990-42a4-be0f-4032c8ec9c9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1130","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:9831ef57-160c-45d1-919f-0939c8decaa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1130","original_object":"UniProtKB:P43219"}
{"id":"b7201637-2aea-425b-af65-3e730ae07f20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129665","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:8fcfbbc4-09df-47ed-a40b-4439f044318c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1155","original_object":"UniProtKB:P35000"}
{"id":"57b3c29b-af48-4e05-bfe9-29d6137cb79d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122552662","predicate":"biolink:affects","object":"NCBIGene:65156","sources":[{"id":"urn:uuid:f79ab710-c815-49ab-9d75-4ade47de31fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10020","original_object":"UniProtKB:Q63707"}
{"id":"966a5a3f-f983-424d-8b21-0e50b49f175a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:7cb1c44c-4fe4-46e0-82e6-2f1373c2c9a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P97288"}
{"id":"db86b514-1fb9-4c41-a4b6-c488a2262620","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78243759","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:e47e4acb-ca0d-4dcc-b792-6f55a7f30269","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9242","original_object":"UniProtKB:P21860"}
{"id":"926b4df1-815d-4589-84b1-fd92aea074da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2527","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:c033f5db-498d-44b3-945e-299ac3fa496e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2527","original_object":"UniProtKB:Q02294"}
{"id":"b75faed4-55d8-4f0f-a811-6bfd2eb4d7be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:347732","sources":[{"id":"urn:uuid:a2fe51f2-b626-4e76-b4a9-0f009470d135","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:Q86XQ3"}
{"id":"1c1d984b-e6b9-482e-9c8f-c3aee7d44c2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DRZ23E4F7","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:6405acbd-c2e3-41e2-ab87-b6d5799c97cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5619","original_object":"UniProtKB:P30542"}
{"id":"878a0592-cb2c-44c1-b0b7-6c8129b51627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:758","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:94520a01-aef5-4863-a752-4c5bed29e9d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:758","original_object":"UniProtKB:P49682"}
{"id":"579bc46a-ea8d-4518-98c7-401b2b02b703","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139486484","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:8eb4de74-31ca-497a-873a-0249561a568d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12895","original_object":"UniProtKB:O75762"}
{"id":"7b67961f-3001-4fe4-9690-bbf79d3d930a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:760","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:e4afa8b6-4df1-42bb-8cb2-f9e107511e04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:760","original_object":"UniProtKB:P51681"}
{"id":"75014f1d-4a89-464b-8701-28d33eedb732","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146273261","predicate":"biolink:affects","object":"NCBIGene:23235","sources":[{"id":"urn:uuid:45a7a7c8-d6a2-4fe0-8c79-11de92e12176","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12157","original_object":"UniProtKB:Q9H0K1"}
{"id":"79e2ced4-b93c-4daf-9223-b8f294f92452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16760286","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:c7230914-69d3-4797-87fb-f6aa5cc730ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5926","original_object":"UniProtKB:P49841"}
{"id":"5a0e3800-e208-4af6-aeb5-e07fc760be30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TD3SSC2VDF","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a90e2ed2-5681-488e-a2f9-c4ca379a2f7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11959","original_object":"UniProtKB:P14416"}
{"id":"698b83ef-7fab-49b5-b4d5-3d003f88be2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135949","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:4dc86d69-bd80-4143-985d-4b6c14f48bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3951","original_object":"UniProtKB:P24530"}
{"id":"058e1ab5-758f-462a-ac04-c9c20e38ceab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17053","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:58768264-9259-4034-9650-7ea57db88102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3309","original_object":"UniProtKB:Q13224"}
{"id":"8bfef8ec-096d-4b0e-8b48-7d5426c2bc12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156271775","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:06592f9f-3ed3-424e-9ba7-deaafeabbd6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13678","original_object":"UniProtKB:O14744"}
{"id":"947980c3-c00b-4511-8381-68335b0d7397","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91666633","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:e2816e9d-1503-4b06-95da-ccffe0a80e7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10003","original_object":"UniProtKB:P35498"}
{"id":"1fd4dbd3-9198-4c4c-b7db-2da28b1d2b3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34952","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:b68eea7d-e668-4c5b-9288-32c1d9c06c87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4297","original_object":"UniProtKB:P14867"}
{"id":"2562c3ac-aebb-46cb-91ea-28c38f9dfd3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:64dfa74f-6da4-419a-94f3-ad542658c615","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P30966"}
{"id":"68991ba8-0692-435d-b141-0403848572fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813905","predicate":"biolink:affects","object":"NCBIGene:166929","sources":[{"id":"urn:uuid:de0c8125-2831-4a22-a786-7d0d762e60b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10054","original_object":"UniProtKB:Q8NHU3"}
{"id":"979f081d-38b0-4ae1-9bad-54aa5b4a5362","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:cbdc18e5-832a-49b8-8760-0adc8b6be90b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P28566"}
{"id":"7744a442-4abd-4dca-ae1e-a160ab1d5b46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:2827","sources":[{"id":"urn:uuid:15c9694c-3bc5-46ff-9baa-40578425f4a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:P46089"}
{"id":"58cfbbc3-a0df-4423-87ef-131755e4d689","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164415","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:7b187a4e-a416-4840-a5eb-20c509fc9ad1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1570","original_object":"UniProtKB:P20789"}
{"id":"14bea843-debc-466b-9ee6-aea71c74606b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56953333","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:ee94e9bb-40a3-4c56-93ee-3e5c2e91bbd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8343","original_object":"UniProtKB:Q9NSD7"}
{"id":"4ba2144c-ddb9-4a8e-8eb5-75036260df40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135810","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:e968fea7-caed-4833-83de-0d7d9724d320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3487","original_object":"UniProtKB:P24530"}
{"id":"9bb8196a-80c6-4271-a681-5d12c7654d0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UX17773O15","predicate":"biolink:affects","object":"NCBIGene:3818","sources":[{"id":"urn:uuid:d7070d85-4187-4727-bef0-9475ba8b2164","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11584","original_object":"UniProtKB:P03952"}
{"id":"03ad607e-3b3c-4824-84d4-bfa55abf64d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130360508","predicate":"biolink:affects","object":"NCBIGene:8529","sources":[{"id":"urn:uuid:8ceedad9-25d3-4c86-a648-df0b3211448a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12767","original_object":"UniProtKB:P78329"}
{"id":"7861d78f-9777-4bd6-a39a-360ced38a4ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:580BNQ45EO","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:7114ae8b-b9f7-4b5b-ba13-75cf4bd7674c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13291","original_object":"UniProtKB:P40763"}
{"id":"2298554b-87a3-4f66-8085-a35e06c4bdc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125398","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:a7e8727f-fd67-476d-a3f7-fe3b6ed5981b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:510","original_object":"UniProtKB:P23944"}
{"id":"efa5c338-2b11-4855-968e-0c7c760b6742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:ac4d9be8-39b8-4284-8407-7cd5d23ea13b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P30994"}
{"id":"babc6908-9b2e-4393-820c-32cc3b126be0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:f77913f9-c130-484f-bc07-40f4106a4414","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08483"}
{"id":"47267a6a-2436-467a-bb21-734e19a06147","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146250992","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:8784f9d7-de9b-46a0-9d90-422498f3f25e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11978","original_object":"UniProtKB:P01116"}
{"id":"edc144c6-57cb-4e8d-8b53-859db078d7b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232494","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:78a0d832-04c0-430d-9ad4-85436d7ae8b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4232","original_object":"UniProtKB:Q9Y210"}
{"id":"eb4d98a8-3225-4046-bc6c-b9b2c1ee22a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231416","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:3ace09e8-a18a-4955-8ebf-1db522fd44ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9257","original_object":"UniProtKB:P34972"}
{"id":"18dc9441-47f1-4c5d-8f04-aa2973bbf951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DX3FHY76FZ","predicate":"biolink:affects","object":"NCBIGene:23411","sources":[{"id":"urn:uuid:c271dabd-41e2-4936-8dd1-139ae8fd322a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7703","original_object":"UniProtKB:Q96EB6"}
{"id":"ac3b2be2-2bd2-4f2d-bb92-20a4c44a83fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63452","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:bc73ef95-50b1-47ad-b469-6ff2d53f0a4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5702","original_object":"UniProtKB:O95835"}
{"id":"5c3520c3-2949-4f5a-9cb0-9e3ba2e0ca48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3844","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:b1d858d9-bd1c-463b-8006-cdc0297fa5dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3844","original_object":"UniProtKB:Q99705"}
{"id":"4e1f2d15-95e4-4d8e-a04e-4e012e24f9e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:9a106375-9fef-4689-9d18-85f7e90ba1de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P22455"}
{"id":"586c3dfa-fe9d-436b-b353-625a68045317","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53318624","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:cd735e39-d678-4ccc-9d10-6a008ef37ae2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6400","original_object":"UniProtKB:P31424"}
{"id":"31052b3c-e953-4c3d-ba99-d21b2d053791","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:3785be30-1c9d-45fa-bddb-6ee53aebedea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:Q96GD4"}
{"id":"c63cec46-204a-4bb8-954f-33944dd34c1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:225865","sources":[{"id":"urn:uuid:3577f39a-78bb-4431-974f-bd8dcba8c94a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q91ZR5"}
{"id":"29d8d27a-5ae6-4356-8d39-098f46f318e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7458","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:3ad1c100-d6de-47ea-bb86-583e03e350e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1629","original_object":"UniProtKB:P41143"}
{"id":"1b4897ed-5236-4e0a-8ea3-f7cac1b6b77f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2955","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:838c13c2-799f-47b6-9f26-bb94063b0f94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6510","original_object":"UniProtKB:O43193"}
{"id":"4692ba36-3bdd-4946-bfd9-98aad65136a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6858272","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:07576092-f6cf-4ac4-a890-d0484b6838e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1612","original_object":"UniProtKB:P41145"}
{"id":"014585fa-41c6-4e53-b3dd-3593fbdf0d39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11313837","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:9eae451e-db73-4317-bf18-bc96aa1d5023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1254","original_object":"UniProtKB:Q9Y5N1"}
{"id":"ab54a83f-c4fb-4a57-8f38-553763528a62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5801","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:315cb0bc-275e-4011-8208-3f32e64ce40a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7198","original_object":"UniProtKB:Q9NYK1"}
{"id":"fd106f80-0436-4869-87dd-8208d55e834b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135694","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:5133c76d-0c75-4b28-881b-c523afae206a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2197","original_object":"UniProtKB:P37288"}
{"id":"fb3a45c5-8ae4-4a54-a168-b583adc28b72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:12878af2-ae8f-4de8-90d7-efec3ed6bb08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P35348"}
{"id":"df2b1b93-d127-4f51-b121-6bb3872fa811","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2062","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:2235ee20-5410-432f-95a8-17d4aa948f2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2062","original_object":"UniProtKB:P30680"}
{"id":"a0b49385-1bc5-4c38-9663-e9c358fcd901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66833213","predicate":"biolink:affects","object":"NCBIGene:384","sources":[{"id":"urn:uuid:c1f2aefa-09ac-46a5-bf71-73ea4be626bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9017","original_object":"UniProtKB:P78540"}
{"id":"e18f0a1f-f81b-49b5-906b-ae4f9fc48cdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2WDS5F2V6Q","predicate":"biolink:affects","object":"NCBIGene:24873","sources":[{"id":"urn:uuid:43b06e8c-d36b-4733-babb-642e33f6138a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2785","original_object":"UniProtKB:P13053"}
{"id":"4e63448d-f9f2-4f2a-84ca-f5a0a34c0eee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6539137","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:461bf1d5-a715-4cbf-a842-078fd771e5fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8033","original_object":"UniProtKB:P49798"}
{"id":"e5fc7fd4-7866-4fee-882f-318930cd40db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144672","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:f5d3df60-f280-4719-ae5f-875ac9099c41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11060","original_object":"UniProtKB:O60674"}
{"id":"0dd6cdb1-e2ca-4146-a45b-d0135ba890a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10100","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:d4be4c06-51b9-403b-88ff-a808c673317e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3322","original_object":"UniProtKB:Q9Y271"}
{"id":"86dc412c-8df8-4a11-a39a-6d77c88989c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86672192","predicate":"biolink:affects","object":"NCBIGene:1215","sources":[{"id":"urn:uuid:22907728-bcd2-45c4-a55e-cc599dc9ba93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9794","original_object":"UniProtKB:P23946"}
{"id":"8a1ca6ed-43a9-487c-951b-765bd80cde7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:455799","predicate":"biolink:affects","object":"NCBIGene:9975","sources":[{"id":"urn:uuid:cb887028-7dc6-4353-ac43-81665417313f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8903","original_object":"UniProtKB:Q14995"}
{"id":"a9776775-6d36-46f9-b722-091dc8570fd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:d7ec7360-b475-4884-9143-5d162b17040d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P43140"}
{"id":"c4a88df3-7ff4-492a-b717-c93cd402d54d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J57O328W4W","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:26597f24-93aa-4cb1-82df-1f6c11f11ba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2307","original_object":"UniProtKB:Q9NR82"}
{"id":"d5b2dfe9-e2c1-42c5-a2ba-9a7d6731ff6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134724","predicate":"biolink:affects","object":"NCBIGene:246787","sources":[{"id":"urn:uuid:596d924a-1ce9-4f2b-9962-bf86e452e054","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9394","original_object":"UniProtKB:Q923I7"}
{"id":"f430254a-55f9-4949-91f0-e0db1a390b83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15971","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:6e7bf11f-2cca-4627-aa4e-b1dbb84517ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3310","original_object":"UniProtKB:P43166"}
{"id":"082d4591-8601-44b0-8c9e-0653cce70177","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:da8c9965-8967-43ab-acd3-611d1b51d375","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P70604"}
{"id":"86225c9e-a497-4504-bcf9-7a012857db49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47520","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:f4d704f4-530a-4934-9451-5cd438c50007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8871","original_object":"UniProtKB:P11511"}
{"id":"74855107-9fa0-40bc-8182-09cc683aebbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177440","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:2f86dc63-0c83-4413-a1ee-3b0cb9808c6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1640","original_object":"UniProtKB:P41145"}
{"id":"524e2ba7-56e1-4bfd-b867-c467bedb7108","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18980163","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:fbbe48a3-6450-4a0b-8248-6e14a7347d03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2709","original_object":"UniProtKB:P37231"}
{"id":"c43e8795-12d7-410d-bcdd-92cb77b283d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9159","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:32bfdd58-01a9-4295-91bf-0a01b9182cc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9159","original_object":"UniProtKB:P35372"}
{"id":"fe8354c0-4b7b-4abf-b5d3-3092903fcdd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:841","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:f1b3175b-e58a-487a-86cb-57a70d3d499a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:841","original_object":"UniProtKB:P49682"}
{"id":"57bb2f20-722d-4c9e-bc7e-bdca63b47aa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9RL37ZZ665","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:9000f0d2-2e2d-416d-bec6-eb5c6f27e6a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7816","original_object":"UniProtKB:P11362"}
{"id":"051fa179-5047-4d79-874c-4818224d0444","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030523","predicate":"biolink:affects","object":"NCBIGene:8111","sources":[{"id":"urn:uuid:9e2ddfcc-7389-4dd8-a750-81951b610145","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10440","original_object":"UniProtKB:Q15743"}
{"id":"b1e491ff-caee-42dd-a81b-f88ef01213a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:11539","sources":[{"id":"urn:uuid:debe5f18-c5b3-42b2-8120-7ab82dfb23d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:Q60612"}
{"id":"28936700-78e5-407a-bc8f-5a6b52cdf150","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17698","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:ce7a1a7d-b5a4-4776-8f75-cb54f5b58075","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10901","original_object":"UniProtKB:Q9NYW2"}
{"id":"026215c9-c256-4261-b741-c0af99e76f3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15650","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:22efbb86-4e2a-44f1-ad9d-c0d4132d7f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3352","original_object":"UniProtKB:Q9NS75"}
{"id":"4d1c2a2e-4b8c-45d3-8abe-5359ed2bbb79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9976312","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:c632673c-ec0a-4343-800e-84d7127dc038","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:181","original_object":"UniProtKB:P28223"}
{"id":"0bfd11f1-2c6b-4457-a9c1-76c02194488f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126535127","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:4192bee9-9729-46a9-95d3-084d21194f19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12079","original_object":"UniProtKB:P11802"}
{"id":"5e8df518-b3f7-47d0-aaa1-f6d65a503f78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SA2ND7EHY4","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:142e98a8-9f98-4e4e-bab6-1f3214877b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8836","original_object":"UniProtKB:P00533"}
{"id":"7ba84478-e893-4756-9eaa-c278d3738978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44598334","predicate":"biolink:affects","object":"NCBIGene:51304","sources":[{"id":"urn:uuid:2c50b99b-a66f-4313-bb13-c9b690de596c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13127","original_object":"UniProtKB:Q9NYG2"}
{"id":"f4e61d64-9ca1-410a-afbf-1c120bca3087","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1X0H7WEC5D","predicate":"biolink:affects","object":"UniProtKB:P15823","sources":[{"id":"urn:uuid:0ca389fb-2284-4175-b6f4-70570ecf9883","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8896","original_object":"UniProtKB:P15823"}
{"id":"cd10d685-62af-48f6-821a-16773c1c0940","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1X96A704XV","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:4687e99d-7b0f-4b0e-bdd8-57e179143670","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9547","original_object":"UniProtKB:P13866"}
{"id":"868c571c-1237-41ec-a1b1-9069b909ac7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:19623ce5-3379-4d19-b473-8c9a102b0b74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:A8MPY1"}
{"id":"3849abf8-cac0-4816-9665-bbb88d1cbdb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58298316","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:96bfc124-e920-40d0-baf3-aa17f905de0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8914","original_object":"UniProtKB:P07333"}
{"id":"05015a20-4f09-4fa6-b244-a379c8fa82db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2WTV10SIKH","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:a0c883d9-000f-4b05-8087-6ec14b5dff3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10473","original_object":"UniProtKB:P14618"}
{"id":"bb2b57b5-e691-4cd0-8c90-329076287a87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46911435","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:83e34711-05c2-4aa0-a4a3-1e09db2e9293","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5807","original_object":"UniProtKB:P47900"}
{"id":"b450ae0b-6bbb-42bc-848b-0b68b4d3253b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:05266839-7eaf-484a-9690-38ded6ef41e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P15387"}
{"id":"2ae5ed27-e79f-49a0-a2b0-092ac2125e49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2153","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:1f48addb-0b5c-4a87-80d1-edf31e0c2a5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2153","original_object":"UniProtKB:Q9UKP6"}
{"id":"affdd27c-2dd4-4a6e-8a84-c4a4ceb3a699","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91408","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:fe1c6895-f983-4a41-b47f-026169db3fed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5716","original_object":"UniProtKB:P52333"}
{"id":"e121654a-5257-4106-8273-836dfe8513fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90848","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:cec54f41-471c-44f2-a552-c19cfb6c189e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5852","original_object":"UniProtKB:P35408"}
{"id":"c0b58ca6-0e8d-4925-bdd1-a421381eb9b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25254550","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:00c05825-9de3-4521-b257-0d546670e3f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10224","original_object":"UniProtKB:Q16581"}
{"id":"95ac980d-3722-4563-aa3c-a9bb38a60102","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6BTT8VA5Z","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:852951b4-fa65-475a-b09d-92dee79a86db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4460","original_object":"UniProtKB:P56719"}
{"id":"b80baa5b-55a6-433b-96fe-2fef1af9b296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22133318","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:4147e8d6-f33a-43e6-b51b-59f5f47a6cb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1354","original_object":"UniProtKB:P48039"}
{"id":"0747e489-4bf9-4970-8094-02589092b7cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50749","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:3add800e-91de-4567-9f35-dfb255253563","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2778","original_object":"UniProtKB:P11473"}
{"id":"1a9be72f-c699-4c71-ab88-110d29ff3e50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R6AXV96CRH","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:bd4d957c-a37a-405e-baec-9f1ec979d1e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9229","original_object":"UniProtKB:P28482"}
{"id":"977e3d3b-0c00-4424-84aa-20fcedff8402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311230","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:d98a81c8-e9e8-4d65-9fe9-369fe682c316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1933","original_object":"UniProtKB:P35408"}
{"id":"48d742cf-bd96-484e-88e5-2b7c9362da91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68299673","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:34ddd96d-003e-49be-8174-bf87cf82e952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13743","original_object":"UniProtKB:P31749"}
{"id":"931b6824-e635-4601-884e-d87221798aff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:3957937a-3b12-46fb-acf8-204199ec5a7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:P78527"}
{"id":"e3bb694d-6a27-4796-8ece-66455d937dd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58056241","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:afb15ca4-dfb3-46a2-b756-8843b3a126b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8084","original_object":"UniProtKB:Q9NWZ3"}
{"id":"264a43bf-bc11-43cc-b4b6-3a27c90dc192","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10048862","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:fa031b55-0896-44b5-a895-2b6eb8e52af6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9415","original_object":"UniProtKB:O43614"}
{"id":"aceb7413-fa7f-4a4f-9393-b8fd6443f577","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:a929b1a1-f1dd-4a29-9ba1-7f424b937a8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P31388"}
{"id":"5a860757-8184-478c-8b33-31c4160edf02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733034","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:7647c54c-cd11-4861-85fb-edbfe6c7ddf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11313","original_object":"UniProtKB:Q92633"}
{"id":"4ca694ee-8c57-4ee9-8169-6f96e4208c93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:87056204","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:256d6c4d-71a2-44b1-a613-c158615b030d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10094","original_object":"UniProtKB:Q06187"}
{"id":"17d76176-b153-4ba1-81c5-cbcca61c48cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46179018","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:94a84969-3490-4af9-9b7d-29e7092d3a0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9367","original_object":"UniProtKB:P11309"}
{"id":"176a8a40-6ffd-48c6-9ca1-eef38262f48e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:a6765474-e876-4630-ae1f-1611ae0a3d49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P34903"}
{"id":"0a123ad9-ea36-40a0-add9-5199d011359c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:4a0a74d0-18ad-400d-a251-a18b880125c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P35348"}
{"id":"ba0f877b-b105-41d5-8f19-a8c6ebacdc09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439091","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:152d1139-107a-40aa-bd1d-18fe479bcf54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5606","original_object":"UniProtKB:P30542"}
{"id":"ff357c12-b856-4149-983e-4078c5734a91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71025","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:6c5cc4f2-dc6b-48b7-9e21-4f9c0db2eca1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7460","original_object":"UniProtKB:P06401"}
{"id":"6b367e69-378c-4cdd-8b68-90864723a1b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9917025","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:5f7f17c1-96d2-47b3-9d16-323c04ef03cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2204","original_object":"UniProtKB:P47901"}
{"id":"4dda8780-95b4-4514-9e63-b3708a9f68c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N673F6W2VH","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:88d62439-f903-4973-bb20-aba11ade8163","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6478","original_object":"UniProtKB:P25774"}
{"id":"2e96d19e-995d-4409-8539-9b0caf6963f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49960","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:29571247-0f89-4f75-ae42-711f2c2a4f96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5717","original_object":"UniProtKB:P00533"}
{"id":"82634aec-9a1a-4208-8839-295caa9bb126","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2707","sources":[{"id":"urn:uuid:1ed4e419-903b-4f3c-87c1-b270103102a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:O75712"}
{"id":"dffcd238-af37-42db-8921-5f407d5efb75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:53011e22-b3e8-4c74-a567-bb335bd60a59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P35368"}
{"id":"346c62e8-c3b6-4aba-bad0-fbdc6aaf60f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44134520","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:f10c959b-aebd-4b43-9437-33a1c4c81872","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2257","original_object":"UniProtKB:P41587"}
{"id":"e10d5451-fcb7-41bc-8a62-3db0d60ab785","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102373294","predicate":"biolink:affects","object":"NCBIGene:255231","sources":[{"id":"urn:uuid:39c713fb-7472-42f8-afcf-a18cad79b333","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11862","original_object":"UniProtKB:Q8IZK6"}
{"id":"657ab46e-343c-4c1c-8f79-5f4e37d0da54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827377","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:121718e0-8cad-4a4f-9cb2-558f0f672022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8598","original_object":"UniProtKB:P08172"}
{"id":"cdcb70a1-5b76-4594-8700-9774c87013d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603900","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:47252349-074c-4be7-b740-0a4d51c4e35c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3936","original_object":"UniProtKB:P30556"}
{"id":"5336d065-dff5-4ccb-9ec0-601f122f2879","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156744887","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:070c2169-27e6-4ba5-9a30-1b629548a1e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13846","original_object":"UniProtKB:P36897"}
{"id":"bb47874b-c477-4a55-a9e1-c75561eefbab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194402","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:78c86b1d-4250-4835-aec8-21a48bad1b2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2199","original_object":"UniProtKB:Q00788"}
{"id":"8f83f15b-8e60-4c94-b394-57c5e73dc6d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5790","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:b4a829f6-5cba-4307-96d7-e3df991f2b02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7082","original_object":"UniProtKB:P41143"}
{"id":"69d0b06b-b807-4650-8e56-f4cab4286aa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2017","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:34bfc23b-acbc-4f46-9643-591ad3f4834d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2017","original_object":"UniProtKB:P30874"}
{"id":"8b387aea-ad95-42ed-9b31-08d0a01bbc14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:857","predicate":"biolink:affects","object":"NCBIGene:2829","sources":[{"id":"urn:uuid:209ff746-c331-49cb-a9fd-5c2e4b35a583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:857","original_object":"UniProtKB:P46094"}
{"id":"24336abc-3d9c-4971-a1e1-d9ab84a04b47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925850","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:cc05ee47-402a-413b-9b44-e345294162e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11565","original_object":"UniProtKB:P23458"}
{"id":"fafa70c5-fa69-4a4f-acfa-2105e14c7f8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:3daad0f1-9028-47fd-a7e3-483fe66bfb39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P29275"}
{"id":"085f5e48-b32d-481d-a6fd-5626fee4c8bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8342","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:bde8ed20-1ded-4f01-b10b-3cf8147ed78e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8342","original_object":"UniProtKB:Q9NSD7"}
{"id":"cee6b9c0-7c5e-4819-b611-25053ff2b3b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10448986","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:c52183a5-57e7-4066-bc86-815f68f70b4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:476","original_object":"UniProtKB:P0DMS8"}
{"id":"44bf270f-b387-4b6c-a498-02c3fd2d3d8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755251","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:b7d434ed-a1f0-42aa-a277-3de43a723512","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6983","original_object":"UniProtKB:Q92633"}
{"id":"6a88047e-2e44-4566-974f-6c3db50c612c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35046","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:50b6058a-d197-42e0-89eb-01451b0c57cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2596","original_object":"UniProtKB:P51787"}
{"id":"0ad6f52d-1f6e-41ed-a0a3-462918e7ff44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DV3HD37UBK","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:da9bd5bb-c69f-4551-9c83-c23e1e9e19fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8075","original_object":"UniProtKB:P37173"}
{"id":"8c84732d-b667-42de-9d44-3a3bf8bac10f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71308247","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:c42681de-641a-468a-afe4-0f916b716edf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9552","original_object":"UniProtKB:O76074"}
{"id":"8fdca43d-c53e-496f-9222-c60e60977af4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:d1cf680a-a81f-4d11-8c9a-d5a45d7a3a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P46098"}
{"id":"e3b507a0-00e4-4dff-b28d-b8bdd970abce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91729","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:31ee11fe-5884-4643-980d-de084bf96d68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6405","original_object":"UniProtKB:Q8TDD5"}
{"id":"3b1f1b24-90c8-4164-bf2a-81f93774ef96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5O1LL04GJ3","predicate":"biolink:affects","object":"NCBIGene:348980","sources":[{"id":"urn:uuid:b09c8d19-e0b4-4ff6-9850-608e69ec667e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2355","original_object":"UniProtKB:O60741"}
{"id":"750debca-56e0-463d-a2ff-895a191382bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:919","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:e8baf4ba-9a39-4ba2-a84f-7cfeab808791","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:919","original_object":"UniProtKB:Q60748"}
{"id":"071869fe-92ce-4419-9369-dea94bf0bca1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U2H19X4WBV","predicate":"biolink:affects","object":"NCBIGene:2872","sources":[{"id":"urn:uuid:02e52bb2-2381-4342-8e87-e0e18bd20b8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10167","original_object":"UniProtKB:Q9HBH9"}
{"id":"763aacde-3b2f-4fb6-a9b4-286866ff7c7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324620","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:8b440574-ea6e-4882-92dc-2dc6e5c225c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:262","original_object":"UniProtKB:P47898"}
{"id":"5cff7f3a-e3eb-4a0e-b983-214894087d2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:25469","sources":[{"id":"urn:uuid:b9b6f129-73c3-4fa5-8b32-8efd80d60a55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:P15385"}
{"id":"2da32bb4-3629-40c0-a63d-57142f7ac4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:02dd8598-dcda-4941-b285-9e5d783c3c61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"mixed_allosteric_modulation","original_subject":"GTOPDB:4366","original_object":"UniProtKB:P48169"}
{"id":"6676d5ff-e45f-4945-b690-6ee7cc0abd8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11753159","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:a8b65887-78c8-4e93-8160-d66c78eb9c28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7679","original_object":"UniProtKB:P35367"}
{"id":"51d0001d-6de8-439d-8ca6-b7662b12a0fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:fd725e95-21a9-4b10-98b3-97266d5148bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P35348"}
{"id":"98adcad8-bdac-4ee3-b849-cdcdee7d212c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755149","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:82f5ff13-b317-4ea6-95c6-f21430da1876","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5731","original_object":"UniProtKB:Q15858"}
{"id":"068e50ce-522e-43b4-9af1-2b519cf1bf77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:678","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:450f8c50-71f5-4b7d-8cb0-31ebfa24660d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:678","original_object":"UniProtKB:P32299"}
{"id":"246c1d5e-1045-4a0f-9233-b086790c7757","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4653","predicate":"biolink:affects","object":"NCBIGene:27115","sources":[{"id":"urn:uuid:ff1a2e01-05a6-426b-8f40-d491d5c7edc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4807","original_object":"UniProtKB:Q9NP56"}
{"id":"a7f99255-1cfd-4c1e-bd3f-74a08af4f313","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:aa9b7223-4fa6-4f03-9412-cb6a6f9ce0de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P28222"}
{"id":"48d8a948-8796-44b5-bd92-98ba900a6487","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15428","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:50c71ce2-dd9a-484e-9290-9e8a67869257","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:727","original_object":"UniProtKB:Q5T6X5"}
{"id":"3e761ca7-11e4-4f5f-88bb-3c1a8bfeb39e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:777","sources":[{"id":"urn:uuid:2da460ba-d393-454a-9857-544a34b31904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q15878"}
{"id":"0699a741-c676-46b2-8de4-5283313a7651","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136970071","predicate":"biolink:affects","object":"NCBIGene:233549","sources":[{"id":"urn:uuid:1b98b54a-54d2-4913-a7db-b0414bbd7cd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12971","original_object":"UniProtKB:Q80W94"}
{"id":"2494235c-c437-4f0b-9752-fe2daba037f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93403","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:7a638e9d-1764-4a6c-bb45-e9a2597f7c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9215","original_object":"UniProtKB:P14416"}
{"id":"1b0a802f-bd19-4c4c-98a7-6576a2848738","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5590","sources":[{"id":"urn:uuid:93f1e55f-626a-4d7d-a45d-accd32afbbf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:Q05513"}
{"id":"409e5d79-f941-464e-af84-bb4ecff0f70d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232811","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:982909a5-a8eb-44d0-b056-2b5fa56ca18b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12074","original_object":"UniProtKB:P50750"}
{"id":"a41308b6-247e-4909-9e5e-c714c882f0b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77260","predicate":"biolink:affects","object":"NCBIGene:495","sources":[{"id":"urn:uuid:b35fecde-59d5-4cc5-8951-085e1dfac635","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4279","original_object":"UniProtKB:P20648"}
{"id":"0e885d76-0e0b-4695-b923-2fb1437d8e42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17757220","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:d3b69671-5a00-441f-a62f-a8b9f169bb21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6982","original_object":"UniProtKB:P61793"}
{"id":"c383a1e9-f847-4eb7-9d1b-7a74499d75b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5715188","predicate":"biolink:affects","object":"NCBIGene:5873","sources":[{"id":"urn:uuid:f71abbde-5575-4230-976b-35fc2f7e457d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9419","original_object":"UniProtKB:P51159"}
{"id":"d3e71f24-9432-4fbd-b2f6-371995fcf84a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45951","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:fcce4665-3478-4ecc-8442-9ec7f7c48f9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:214","original_object":"UniProtKB:P35367"}
{"id":"758b3c67-b191-4d6d-8c01-2cc2db859b96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:84327","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:75bd34e3-6eaa-468e-9b31-7c0d25a65889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8004","original_object":"UniProtKB:P42345"}
{"id":"f6c63e44-c52b-492d-bed8-b7329e48bc4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2874943","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:7baa6775-811c-4153-a6d9-9238daee233c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8517","original_object":"UniProtKB:Q8TCW9"}
{"id":"acba372b-5889-4d09-a7fe-cd508a900b85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4697","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:e7551f8b-6c67-4007-939a-98a65b650e8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2309","original_object":"UniProtKB:Q13133"}
{"id":"ba36f79e-1816-4352-814e-a4066f808f4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755158","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:f71cb420-6511-4293-9304-dc41ade3eb03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5809","original_object":"UniProtKB:P47900"}
{"id":"0c6fe044-e59e-44c9-ade9-78d5f54aeb58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2K59L7G59M","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:1fb72036-c14a-457d-8422-82cb0d83d30a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9728","original_object":"UniProtKB:P42336"}
{"id":"b7eb7766-8462-4cda-8398-a535bf7447ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53340664","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:c446bf8e-f479-4510-9d25-03981e2caae6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8074","original_object":"UniProtKB:P07948"}
{"id":"88686488-9b11-49c6-93b5-117a4bfb7a4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1511","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:4bf731a6-250e-4a44-b663-45460f129330","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1511","original_object":"UniProtKB:Q63447"}
{"id":"059c85ed-c2f1-4722-9148-c86eabd03e12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229970","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:a0c7ecb1-4f0f-4983-a425-e9cc1a7b6eee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13289","original_object":"UniProtKB:Q96KQ7"}
{"id":"88e27e7e-ecaa-4cf3-a781-0c7cbb3628aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4702","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:cbed96f8-2e04-431f-8571-997f17d22015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6810","original_object":"UniProtKB:P00915"}
{"id":"32a16d25-b4dc-4a0e-b8d2-7b94f2a5d06f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16958","predicate":"biolink:affects","object":"NCBIGene:116512","sources":[{"id":"urn:uuid:32bb6ae8-fd2a-44d8-8d82-8af9f20b00c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2365","original_object":"UniProtKB:Q8TDS7"}
{"id":"5b54ef94-c103-4a57-a31b-dd382c270cc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3763","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:d9b705bb-3a15-4c23-9aa9-24879fcf87d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6636","original_object":"UniProtKB:P21397"}
{"id":"69aac4bf-26e3-406e-9bec-f91eed9bd2dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:912","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:08cd04a0-f7e7-4886-b85e-74c22b4a05d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:912","original_object":"UniProtKB:P34998"}
{"id":"6aa6a1ea-112b-4a33-b7f2-408ba507e430","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817403","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:1ae25347-d9ad-4b0a-903a-c276dbebb499","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1289","original_object":"UniProtKB:Q969F8"}
{"id":"62c42f94-1d7f-48af-b6c5-2d996a3fa677","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93359","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:20386930-83f1-4d61-aad9-2822e090b65d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1255","original_object":"UniProtKB:Q9Y5N1"}
{"id":"443ee2fe-0253-433b-98d9-668153b36828","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95245","predicate":"biolink:affects","object":"NCBIGene:19090","sources":[{"id":"urn:uuid:7341207e-2bff-4b0b-991f-0fb3726bcee9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5960","original_object":"UniProtKB:P97313"}
{"id":"7554105b-09bf-43f4-a9c7-1254b209c2c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W9SQ1X2NPZ","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:5d7d09fb-3e5c-48c4-bcc4-9cb6e6854907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10453","original_object":"UniProtKB:P21397"}
{"id":"71839db5-3231-4330-89d0-2c9ccfe1ce4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:03KSI6WLXH","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:38c4ad2c-3026-4d3b-8cd1-ce7235126f91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9150","original_object":"UniProtKB:P35372"}
{"id":"7e83454c-3a3a-4e1b-b42b-000e15074fec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1275","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:e744ea92-7991-49c3-923f-d046b4868582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1275","original_object":"UniProtKB:Q9H3N8"}
{"id":"9d93053a-d1f7-4da6-9bbb-21307fb9181d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125484","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:5054d87e-bb83-4dda-a373-8e927976d50b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9233","original_object":"UniProtKB:P21554"}
{"id":"46601d60-c489-4c6a-b0b4-f502459b88a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16330","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:0dc08d67-c9bd-49ab-bba1-cfe97d8405c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2856","original_object":"UniProtKB:P10275"}
{"id":"991d5b68-9f7c-4ac1-8c26-3adc2bd5c261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177556","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:8f69be41-78f6-47b5-953f-7afca5ba2c55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3327","original_object":"UniProtKB:Q9Y271"}
{"id":"e2f72ad2-b8e9-4993-bcd4-27f383273d93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49848557","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:55022541-2505-4f0a-8c67-53f1a6a074c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9492","original_object":"UniProtKB:P21453"}
{"id":"df1e05fa-b55a-4f0d-bacc-93eac11cc33b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UTD8BCW6B8","predicate":"biolink:affects","object":"NCBIGene:227289","sources":[{"id":"urn:uuid:9ede2c6b-3a78-4e3c-bfbb-303528ea2b25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7048","original_object":"UniProtKB:Q80SS6"}
{"id":"92b34993-c75f-4dd5-8f8a-00571b90d05a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13113","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:93436711-7400-4498-bb9d-fdbd935a1b9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13113","original_object":"UniProtKB:P34913"}
{"id":"abb63ddc-e89a-411a-b92a-5299df2668fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163410393","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:ffeff02f-e98a-4f67-9206-e02519e28d0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12057","original_object":"UniProtKB:P45452"}
{"id":"fdfebf19-4487-4b24-9fe2-edf189ad3c54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16082712","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:273bac9e-ac92-4b1c-94d3-6e4f7a00b63c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6202","original_object":"UniProtKB:Q15391"}
{"id":"5f9ac1f1-38ad-4d44-875e-309ef353afa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1027","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:9eb9f116-db54-42b8-bd5b-2c96711bc3e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1027","original_object":"UniProtKB:P21462"}
{"id":"597890d4-7ca9-4894-a2be-81df68fa714f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8337","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:ee066ce1-0d51-4bf6-ab85-e7791f8b677d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8337","original_object":"UniProtKB:Q9NSD7"}
{"id":"8e09bb85-f8e4-469e-97d1-d0e62daf70da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135747628","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:5f852d10-8df7-4df7-9d67-875ac0257c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10195","original_object":"UniProtKB:Q9P1W9"}
{"id":"a70db488-6b57-4c7c-aae6-a53d5ce0f27f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2219","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:6bc93325-2472-401f-966d-55b8fe6f518c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2219","original_object":"UniProtKB:P30559"}
{"id":"b62dd824-cd3d-431f-846d-e6a92c97cc26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11741525","predicate":"biolink:affects","object":"NCBIGene:5730","sources":[{"id":"urn:uuid:d1206aaf-1c32-46dd-8aaf-f94bf747fb76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10261","original_object":"UniProtKB:P41222"}
{"id":"fc140a04-c2bd-4215-9c18-3cc85d5fe9ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:6ac66d9b-e73e-4660-89ab-72bff3c2276d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q8K424"}
{"id":"5986413a-48ef-4b95-967a-c556eac5a3f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:5610","sources":[{"id":"urn:uuid:28e96ae8-353c-42bc-ae8a-e1d948505258","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:P19525"}
{"id":"048946cd-80c5-4c7e-9935-8255e2d86978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:d7afeee1-bdc6-4557-8db4-77832071b84d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:Q15858"}
{"id":"84e6f378-6d2b-4b34-8ad8-a16b8d00a957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12586","predicate":"biolink:affects","object":"NCBIGene:80381","sources":[{"id":"urn:uuid:2a0fc602-2c93-4174-9bd1-3292186699b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12586","original_object":"UniProtKB:Q5ZPR3"}
{"id":"a5d686ed-f6e6-4ff9-ab3c-e48701614e9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1V3OH20HG","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:63763f2b-5841-4dc0-9d21-99eb759a6b04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10504","original_object":"UniProtKB:Q99572"}
{"id":"e85aca84-6a99-4e13-bb72-53d25c2f82ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167309","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:c56d1cfa-298b-48f4-b0bc-9850acd37eb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5458","original_object":"UniProtKB:P35372"}
{"id":"2a53a6e2-ac01-4c61-a14e-a2ea6fb2be85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P3C87ZBO3K","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:affae893-1475-469a-b547-164efbcd83fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6154","original_object":"UniProtKB:Q15722"}
{"id":"067c285d-fc23-4f90-b2d4-9fbaf029660b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95021","predicate":"biolink:affects","object":"NCBIGene:14450","sources":[{"id":"urn:uuid:82b72a39-6713-4a19-ae4d-1ea8f84dfbd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6837","original_object":"UniProtKB:Q64737"}
{"id":"2316d107-d5ac-4d8a-a213-03834b91b59b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7925","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:846a54ba-ab33-4688-955d-1d6b3037dd12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7925","original_object":"UniProtKB:Q9HB89"}
{"id":"da3e9754-9136-422d-83fa-7b2c386c959e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604712","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:ebd272f4-c21e-4278-8b29-bdf870d5a4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1366","original_object":"UniProtKB:P23385"}
{"id":"9bdd6662-d183-4034-bb5e-d23c2b2a6dcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146637574","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:a3071e39-ab52-43eb-8765-a1a7ef8da22e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13958","original_object":"UniProtKB:O95835"}
{"id":"a5dc9d5b-05a1-4f73-958d-5e0104739528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9957516","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:0d9e3791-e4da-480a-bc49-bd44ada50d59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7778","original_object":"UniProtKB:P48039"}
{"id":"1226c01c-f97b-4714-bde1-774a195d676c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138108958","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:501f90a9-5bc9-4999-888d-d483c7a8c56a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10529","original_object":"UniProtKB:Q9UM73"}
{"id":"3fdf95e8-a6d6-486a-a58a-b335ba3e1b21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73058507","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:fea40ccf-e02d-404e-af56-a305cd427e50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10239","original_object":"UniProtKB:O00222"}
{"id":"100ee3cb-974e-4add-9ced-13a29c8e9cf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8772","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:ba28d625-8db4-487e-92f8-45d4ac77a737","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2820","original_object":"UniProtKB:Q92731"}
{"id":"38117adf-bc7e-4ee2-926c-1230cfb81669","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:612BYT76F3","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:2c177952-faad-4b8b-949a-4e3467751973","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8946","original_object":"UniProtKB:Q14416"}
{"id":"9824b3b8-ca52-4c56-a758-197cbd5be34b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228223","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:45ebdb37-36da-416f-8d06-3cbb44299ae1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6677","original_object":"UniProtKB:Q99720"}
{"id":"b6bf15e8-a69c-478e-80a3-7348d9660baf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232977","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:c0f6f8bb-a3ef-47f4-8d3c-396a6b02791a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10671","original_object":"UniProtKB:Q9H2K2"}
{"id":"dff28fc1-5067-4556-a59e-7b31a1b0d59c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91832","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:89f241ae-1904-4409-81a1-02b7a483a61c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3285","original_object":"UniProtKB:P29275"}
{"id":"7d26332f-94ee-4216-b9a6-4b5f9c864116","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:4b4ddb30-a5b7-4fc5-9e91-61a8a6ed27f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:P42345"}
{"id":"8597bd55-30ef-4860-841b-520b3e98ebae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94609","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2c54e6a6-1b8a-419e-95a3-48c30088a097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:356","original_object":"UniProtKB:P08172"}
{"id":"9cd853eb-1ddd-4e9f-9cae-09bce6d1716f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91333","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:899dd636-b824-45ab-b16d-0bd779a24bf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5684","original_object":"UniProtKB:P53350"}
{"id":"5e37b41c-b302-4583-8eef-c9d6dc387224","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6264","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:adcbdb5e-529f-4ad4-87c4-384ee2ea0fd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6264","original_object":"UniProtKB:P25090"}
{"id":"0d990a42-ccfa-4319-864c-60831c479e82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:f8c82030-373d-478e-b4a8-a04a0b8cf969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:P42336"}
{"id":"68ffc5a0-2b71-45b4-b1a8-cb9827ae2a07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:765","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:9c5a6123-1fd7-4874-9325-417f5fc84ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:765","original_object":"UniProtKB:P41597"}
{"id":"7256932c-c015-421e-9fdc-0dcdee0ff0e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24827312","predicate":"biolink:affects","object":"NCBIGene:59272","sources":[{"id":"urn:uuid:28321e04-e9e3-4d76-823e-70b3bd6ddc8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6555","original_object":"UniProtKB:Q9BYF1"}
{"id":"ee99327c-1a4b-46c2-92bc-0117d6380349","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3112","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:f82553cf-ac2c-4a06-be3a-8b2faa24c1f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7128","original_object":"UniProtKB:P11229"}
{"id":"5587025e-6813-4507-80d4-4eb8efe75b6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0JSR7Z0NB6","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:d2bbd1d1-25e0-46c9-89cb-11654cc5c93d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10505","original_object":"UniProtKB:P08581"}
{"id":"a76490d9-3ceb-49b8-acb9-9e5812559dca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3TY57MQ4OA","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:8b41c8c2-8cec-43b5-8321-22eaae4372ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2202","original_object":"UniProtKB:P47901"}
{"id":"454417b6-27aa-4628-9744-47ef9c8d208a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656400","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:a431eb65-5537-4dc8-9c0e-82fabd116398","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1220","original_object":"UniProtKB:P35367"}
{"id":"423d4953-39a0-45d0-9490-484d4fe7f7db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:7b2043d8-952d-4af1-99d5-a5c22feabd58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:P23979"}
{"id":"903bc88b-ca97-4afa-96be-ccf7d8ca4395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154642303","predicate":"biolink:affects","object":"NCBIGene:65156","sources":[{"id":"urn:uuid:92a36085-61e6-456b-b556-db4e6c9a1b02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12105","original_object":"UniProtKB:Q63707"}
{"id":"04b90850-6bfb-4ea2-bbd4-54a21e0566b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:694f9fe9-afbb-4967-9a1c-83fd3ce72655","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:P22607"}
{"id":"533d7101-ed6c-4d8a-9e9b-dda6369a02c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:33639WNC7Q","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:4fdf2934-03b9-4c88-ac92-20068ab54299","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8793","original_object":"UniProtKB:P42336"}
{"id":"9c48c796-cd5a-44ce-a43b-df80e5e5307a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23642227","predicate":"biolink:affects","object":"NCBIGene:5696","sources":[{"id":"urn:uuid:10d0334e-7d21-4ba0-b8a2-3182873bd9a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9031","original_object":"UniProtKB:P28062"}
{"id":"03069000-7cd9-4c6f-b031-12a38bdea2f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:658","sources":[{"id":"urn:uuid:c48955ee-9676-46a0-a1cb-be5196b340ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:O00238"}
{"id":"7f984fd0-4be7-4002-a88a-655e7b049034","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:05dc2317-1bff-4be4-929e-ccdba6696bce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:P04629"}
{"id":"9de8ab44-b5d6-448b-a8d1-db94952b6ce4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:5ae464ad-323e-489e-8839-6d9742925fe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q07652"}
{"id":"d9590a1f-36c9-4449-83c3-84b6421f5d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63451","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:4254d756-8a93-4152-9a26-8ce1ded42542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7877","original_object":"UniProtKB:P22607"}
{"id":"c86ea415-d27e-435e-9f98-5d30190167e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146026181","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:2f4d6fd3-7e45-45e7-be4e-7049f8690b1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13382","original_object":"UniProtKB:P07711"}
{"id":"205ab516-827b-47d1-9aff-c764e321c773","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138993662","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:d42e797e-482d-4253-8fad-0a1c6b144236","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10666","original_object":"UniProtKB:P49286"}
{"id":"94401f98-5fbd-4ff6-93dd-d1139d11804e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177520","predicate":"biolink:affects","object":"NCBIGene:4312","sources":[{"id":"urn:uuid:d4badf8a-bc10-4f94-a71c-d2e7b8f7624a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6482","original_object":"UniProtKB:P03956"}
{"id":"0e704c68-03b4-47b3-aea0-51904a2d9a4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:11183","sources":[{"id":"urn:uuid:20ff0bca-af07-4ccd-9ae9-9882e6e722c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q9Y4K4"}
{"id":"b653a618-ce58-47d0-9db3-33450618b0e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93452","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:3e8470be-96df-4f5b-8919-e69797b6d60e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4296","original_object":"UniProtKB:P31644"}
{"id":"ed086892-3ce3-474e-beb1-87b21977e404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3821","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:2e68500f-91de-4304-9e74-66aa2280090d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3821","original_object":"UniProtKB:P32239"}
{"id":"518ad20a-662c-47f0-aba6-97cc777a34e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:26175b8a-5426-410b-9e5b-d2a19ac32014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P32305"}
{"id":"ac02558d-1d52-401f-9afa-89cbc02f2c12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50182","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:eba7e2a8-b2c0-4bc7-a5e7-3e0df0d42f19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11208","original_object":"UniProtKB:Q9NQS5"}
{"id":"12a6684e-6759-404d-8eed-dbe51069f1ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:1e8498f6-96f1-43e0-8fda-5c13796d532a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P31388"}
{"id":"9b868467-d227-431e-ab4c-1b8118aa239d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40532","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:6e74898a-31b2-4c9a-b36b-7ce99bb15172","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4236","original_object":"UniProtKB:P51575"}
{"id":"076537a7-a9af-4277-be95-96d1bf6cab90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311029","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:6748f775-c18d-4e5d-bf63-16ea98ec9b45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:234","original_object":"UniProtKB:Q62758"}
{"id":"68dd2f3f-f554-45fc-a845-ab582846eac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:91572114-756f-4427-8102-3e592321360d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P30872"}
{"id":"a33042c7-e4bf-4101-817f-06f9e4b4979f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49871766","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:0e38e86f-f3ec-4f8d-a924-92d1ccf928f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6170","original_object":"UniProtKB:P32247"}
{"id":"abf0c1d6-f47e-4455-a4df-a1afa0ce6c73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15971","predicate":"biolink:affects","object":"NCBIGene:763","sources":[{"id":"urn:uuid:22e039c5-3b52-4027-9263-aa53ddbe60f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3310","original_object":"UniProtKB:P35218"}
{"id":"94d928a5-796a-4b16-86da-ba4d80ff4960","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:c9c9045c-03c9-421e-b080-1922528f8e34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P11362"}
{"id":"e493d52d-27dd-4245-97c2-408c46f02a4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2043","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:72cc8ae8-101f-4af1-9834-4f8bba35d4f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2043","original_object":"UniProtKB:P30874"}
{"id":"978f66a2-7b07-488a-967d-ea3d67196449","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162565","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:0c433603-4a1a-4863-8c33-d3024af77d0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1716","original_object":"UniProtKB:P47900"}
{"id":"6a4dfe0a-f63a-4cbb-b53e-a81a07ad69d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38322","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:4413224e-13af-452d-a7d7-922a67027016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:303","original_object":"UniProtKB:P20309"}
{"id":"36a43dc5-c7a9-43be-a92c-07fb4b0bb8f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:af2c93b9-86c3-4170-9050-baebdefddc8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q923J1"}
{"id":"25e95c8e-217d-4bf3-bfa3-e7e3aa847834","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:315e9b9d-fd57-43dc-abd3-ab051ed93530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:P42680"}
{"id":"4a55047d-d4dd-4525-b466-3eef79af3f48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699465","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:d0aa847a-a157-442b-a874-8d4506e7158a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11226","original_object":"UniProtKB:Q6W5P4"}
{"id":"e94f62b6-632b-4b3f-ade8-764fbf6f6724","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2552","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:fbe46634-1925-4d77-bfe3-9b390429066d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2552","original_object":"UniProtKB:P63142"}
{"id":"2652544f-4fd8-4d72-b0fc-6e4474344ee0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:4d1d18a8-d497-4b9f-ab58-dede0a5b5032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:Q91ZY2"}
{"id":"b835b7c6-5f5d-4815-8420-358c1c98c298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG8BT6T9MB","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:af463a09-b7c0-4504-9ee7-ca7c149529db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5993","original_object":"UniProtKB:P00533"}
{"id":"3754ff36-1fd7-41a0-87bc-24cddd9cdb1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TN7CUD1NGA","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:c614f05d-94ed-4b84-95e9-44333a17aade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11414","original_object":"UniProtKB:P11362"}
{"id":"31511225-902f-4835-ba79-49764fd1365c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2209","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:aeaa2f0f-6e66-4555-b4d8-08aef4b696f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2209","original_object":"UniProtKB:P37288"}
{"id":"1f4d873c-8817-469e-9da2-8f7ce5e6635b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OEP8JJ3OZR","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:0daca1a2-9c4c-4af1-ab67-4a5c6149198b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9425","original_object":"UniProtKB:Q12809"}
{"id":"6479a55a-0e4f-4dba-9a18-5b5a16beadaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:44da3833-8bd7-4f6d-bd1e-329915e4afd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P30542"}
{"id":"dbad80fe-38aa-4fa8-84f7-f5d850ef2aec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44465558","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:156f4f7e-3220-4380-97f5-aa9b9b3b71a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8196","original_object":"UniProtKB:O43318"}
{"id":"b4180bc7-a034-4bed-a30d-5e6f726310ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16584","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:0c7c2b95-0331-4ba0-9a85-30e644f33c9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3048","original_object":"UniProtKB:Q8NET8"}
{"id":"19a90989-5716-49e2-82be-a8e8e908aade","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1030","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:0b4c9285-376d-4bea-858e-e607727c9557","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1030","original_object":"UniProtKB:P25090"}
{"id":"d27aeb2c-4513-41c6-ba26-e58c6f4520a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:e4654143-0b53-4fef-90aa-82d7c01bf020","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:P78527"}
{"id":"5b4f469e-e079-4d99-a9b4-d12cec152a2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129320516","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:e90ab0d8-0156-473d-b819-ba5ab4d9533a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9586","original_object":"UniProtKB:P55085"}
{"id":"748aa5b1-6a6e-4077-8d30-d460c62e4939","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2896","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:194a534d-ade5-4a42-a960-047cca59569f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2603","original_object":"UniProtKB:Q12809"}
{"id":"5437ec67-269f-4387-8a9d-58c1d5f18ca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5896","predicate":"biolink:affects","object":"NCBIGene:229214","sources":[{"id":"urn:uuid:dd430b89-cbde-44d5-867e-ad1824072d5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5896","original_object":"UniProtKB:P83861"}
{"id":"9640b7f7-c7ef-4385-a8b7-cf04ade53b16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131168","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:c3e35bba-69fb-4bbf-8d4b-a898749ad32a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7890","original_object":"UniProtKB:P31751"}
{"id":"fc0b38f0-7e27-4ce8-bf6c-be82e8607f6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312144","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:1c16109f-203d-4a74-bce7-ffb02d8d81bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:275","original_object":"UniProtKB:P50406"}
{"id":"d2f5a320-4671-4c3c-80fe-f0c400d4208e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:200HA2LIMK","predicate":"biolink:affects","object":"NCBIGene:4296","sources":[{"id":"urn:uuid:8cd33b04-11ca-429b-805c-2a544f46d1d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8173","original_object":"UniProtKB:Q16584"}
{"id":"debcf577-5523-4c18-bcca-21cfbfb3237b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:518962","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:1bde3a40-dbbc-41d2-8739-9c76c8e105e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1625","original_object":"UniProtKB:P41143"}
{"id":"b84ad29c-bae8-40c4-8314-0f403355ce4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34545","predicate":"biolink:affects","object":"NCBIGene:16535","sources":[{"id":"urn:uuid:6cf73ec9-3237-411e-a9a5-b04df988fe3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2588","original_object":"UniProtKB:P97414"}
{"id":"83904729-7a84-441e-af81-c4f7d68b2642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16197445","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:e620991a-a7f1-4c02-8983-aaf5e5deeb27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:852","original_object":"UniProtKB:P61073"}
{"id":"9f45779b-1c4e-4d27-ba34-880b84da13a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:5342ab26-8c28-4cbf-95ba-6439a9d9cfa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:Q01959"}
{"id":"57507433-fc74-4771-9fcb-b0219a73ad2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1478","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:603cdc08-a91b-4667-836e-931326cf8ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1478","original_object":"UniProtKB:Q9GZQ6"}
{"id":"8a4ad268-d337-4949-a2a9-23ad73836206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:479b5fcb-a342-4828-9c70-0df63ef563ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P09619"}
{"id":"650c1756-4886-4966-aae5-b635625f3aa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023738","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:bcdbc259-dbe1-448c-adea-0f4bb1ea9a0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8038","original_object":"UniProtKB:Q15418"}
{"id":"99b4a761-8b0d-4085-9a71-34bb6e2cdd01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177467","predicate":"biolink:affects","object":"NCBIGene:290","sources":[{"id":"urn:uuid:c5618b80-048f-44c4-9371-1e4360258405","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11538","original_object":"UniProtKB:P15144"}
{"id":"80ffaefd-68f1-408c-9ab4-b6ed322d960f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:0b9f190e-d75c-48cc-ace7-acda72f2a9e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30935"}
{"id":"4d84c666-c756-4b8c-a1c7-1aedfbad4535","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7983","predicate":"biolink:affects","object":"NCBIGene:945","sources":[{"id":"urn:uuid:e0f9ef1c-eb69-492b-ad10-d2467f1bf7e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7983","original_object":"UniProtKB:P20138"}
{"id":"ab9dd333-9401-4313-8427-a408240f50c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9887077","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:987316be-1ea8-40ed-a166-06933f2451c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8868","original_object":"UniProtKB:P35372"}
{"id":"f03c7792-de65-4727-8820-cf47d57c65cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182436","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:a6562590-13e0-49dd-8f34-543e41cb425e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7495","original_object":"UniProtKB:Q9BY41"}
{"id":"484cbc64-a449-46a6-b0b3-2d3132c3efa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:848294c0-0ccb-41cd-9e6c-7f2ec6573ffb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P14416"}
{"id":"bf3eee29-ce0a-4c60-b286-9f844ba96506","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65346","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:d267f121-0074-4af3-bebd-5c0a0cb6d5e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7449","original_object":"UniProtKB:P08173"}
{"id":"28a04f1e-4246-4a8e-8ff9-add98d98e637","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:614f698b-6f4a-46a5-bbc7-da6167f8d8a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:Q9UHC3"}
{"id":"13c82a3d-69c4-46d0-bf28-d11d82c6a947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2186","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:ccbd5efc-8e6d-4e1a-b4c8-583dc5405cf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2186","original_object":"UniProtKB:P70536"}
{"id":"e65cdd09-acfd-4847-88cb-8adabb5f5631","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:879A12466H","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:f9d0f28b-145f-410e-bd8a-b1876bda9ee3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:909","original_object":"UniProtKB:P30553"}
{"id":"fa39c31e-1cdb-4bfb-b719-908241ad678c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317097","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:9c138861-2c6e-4b7b-b556-d21e84acb752","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7724","original_object":"UniProtKB:O43497"}
{"id":"07e1c70e-1cdf-4597-9726-ec1bc53f11f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:ea72a413-bede-4104-9488-ad2cb6d16fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P21917"}
{"id":"c9792271-047e-4298-8e58-b2686392a784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5AP1ZW859M","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:47eff02c-5e26-4f68-95de-4c2cbf96bac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9001","original_object":"UniProtKB:O00519"}
{"id":"37e7a55f-cd9f-4751-9d8f-3d72230c31eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147075611","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:29979c68-150b-496d-8afa-5b7923e29779","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12643","original_object":"UniProtKB:Q9UQD0"}
{"id":"09942bc3-feb8-468f-874b-76a33b0d9300","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MIA4WMP8QN","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:b3213274-f0a8-4f6d-a919-4464ce0d5f1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12648","original_object":"UniProtKB:Q9P0X4"}
{"id":"02aef554-222a-4885-ade4-3a8abc79f8ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1502","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:365958d2-a754-41b0-97c8-ca074452c654","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1502","original_object":"UniProtKB:P48145"}
{"id":"fea0c1e3-9288-4cbc-a91f-136df578ae24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231618","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:23550739-daa3-4edc-abc7-b69a8b1404b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2817","original_object":"UniProtKB:Q99527"}
{"id":"378a2872-b309-40f0-a6bc-2d501239e72c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67436561","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:e8501abd-250d-4d4a-a8b8-dce1c9552989","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9982","original_object":"UniProtKB:P56817"}
{"id":"b6753079-4caf-4323-a6bc-f89ac7e38d85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311003","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:4b50c362-6993-4410-8fa4-b88dc2427b53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1600","original_object":"UniProtKB:P41145"}
{"id":"1f9b8277-dd67-4291-94b5-cdd61d9aaee4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2549","predicate":"biolink:affects","object":"UniProtKB:P17659","sources":[{"id":"urn:uuid:02b87c31-c396-4313-94e5-607f40a3bd07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2549","original_object":"UniProtKB:P17659"}
{"id":"e5913d76-3fc9-4471-813d-82a53a1fb1c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11672811","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:178f616c-ec45-4df3-ae1c-b01fe508d6de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5790","original_object":"UniProtKB:Q8TDS4"}
{"id":"15a869c2-1916-4767-b819-5f0d60a47fd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2544","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:95f2628a-45f3-4ac6-8800-5635088fc6d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2544","original_object":"UniProtKB:P63142"}
{"id":"10fa1385-2eb3-4565-81e2-2164356c3fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94802","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:baad2c6c-271d-4138-87f1-76090161f04c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2172","original_object":"UniProtKB:P30518"}
{"id":"8d771654-2d9d-4445-9e64-5e6f7b87d0ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10454","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:3b027267-d2c9-4d54-8014-8580bc4c2a39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:948","original_object":"UniProtKB:P35462"}
{"id":"493b40e0-7836-4527-8dd5-7ea3bdd8d130","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422752","predicate":"biolink:affects","object":"NCBIGene:121278","sources":[{"id":"urn:uuid:2b90b843-c8e2-4f5e-b00a-1c3a032e289a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12993","original_object":"UniProtKB:Q8IWU9"}
{"id":"cffa288c-4923-4621-95c9-6a304c31d810","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9840951","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:47079778-0641-4e1e-afd7-a54a9bfb2e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3347","original_object":"UniProtKB:Q13255"}
{"id":"f57f0692-e2ec-4ed1-8786-abbb2b6f3775","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197230","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:6d1a2477-287b-4649-8351-02344f819dd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1968","original_object":"UniProtKB:P43119"}
{"id":"4e975ce9-8f4b-4629-9541-6b51386ec641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:5ed65efe-5094-467a-bcca-a9bbe22fddea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08172"}
{"id":"59a39864-e0f0-4d66-9b99-a21160367d99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2029","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:4887b7a5-fa5c-4d57-8789-953eadf63295","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2029","original_object":"UniProtKB:P32745"}
{"id":"ed4cad54-db7f-4a08-9185-e57c5d253aad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17276","predicate":"biolink:affects","object":"NCBIGene:9963","sources":[{"id":"urn:uuid:9b3f5344-8cb8-4207-82db-76c70dfd9663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4285","original_object":"UniProtKB:Q9UHI7"}
{"id":"b0edc644-f2b1-49e6-8563-50d80fdc5440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136218973","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:8cedf976-1b3e-4a1a-a3b1-6fe7b7f1d784","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5590","original_object":"UniProtKB:P29275"}
{"id":"d958ef94-5580-4236-8d1d-13be0c81d156","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431484","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:94e5aa30-a535-44e9-9682-72427fb8e6de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10124","original_object":"UniProtKB:P34913"}
{"id":"12d27ab0-9767-43ea-a086-57273a65e67e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75124304","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:abae552b-8fa2-402f-93e5-a8dc58df05df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7521","original_object":"UniProtKB:Q15059"}
{"id":"5fdaa9ba-a787-474b-afa3-7911b4a91f2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124037380","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:777d0757-c015-405e-a533-1e2e080b54c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9388","original_object":"UniProtKB:O14965"}
{"id":"a48a6b2a-3efe-4821-b654-b4ab2ec94774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2531","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:3254c101-2bba-430d-8fcb-b9ea29351a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2531","original_object":"UniProtKB:Q02294"}
{"id":"944fe04e-2c4a-4713-a9b0-a43928923986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:13609","sources":[{"id":"urn:uuid:8e1a069e-fc33-49e6-a3dd-e79cf37258a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:O08530"}
{"id":"99734e3a-a26d-429d-b87b-35176b232a93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6954180","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:1fdda523-b956-4900-923a-361188224bb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:286","original_object":"UniProtKB:P08173"}
{"id":"c49b8755-9f73-437b-804a-a281fabe94b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11337722","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:4d49a977-2558-4f22-af16-3fd40f9d99d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6351","original_object":"UniProtKB:P23385"}
{"id":"43262fad-5315-46ab-8a63-ea285ab262cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1532","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:8890a986-40cd-4450-be9e-f93baf838e5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1532","original_object":"UniProtKB:Q9ERC0"}
{"id":"4477d9e3-055d-48af-b3ad-d5e84df6153d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139330094","predicate":"biolink:affects","object":"NCBIGene:5298","sources":[{"id":"urn:uuid:1293dee3-2384-4c20-9d54-14d13e2df65c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12181","original_object":"UniProtKB:Q9UBF8"}
{"id":"b5de0162-0f8e-4850-9ca8-6b2cf73094de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Z3QHB00LB","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:6d24bc9c-574a-48dc-9b46-3e1fcbd98d2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8383","original_object":"UniProtKB:P42338"}
{"id":"983326f1-9357-4995-afd7-eb5cf01fed0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16062593","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:594302d8-a449-412f-9025-ca6b6d114e9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1407","original_object":"UniProtKB:O15303"}
{"id":"97c36c22-d12e-4b4e-bafb-03761c0d40b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:e4883c6e-4840-49f5-b0b0-ba7889cca976","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P18089"}
{"id":"2b60dd9c-5a57-4ede-a66a-818af22277e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75593419","predicate":"biolink:affects","object":"NCBIGene:9159","sources":[{"id":"urn:uuid:50de70d2-53bf-4cb9-b94d-e74bc782fac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8658","original_object":"UniProtKB:Q16549"}
{"id":"b6b3b0b6-dd18-4079-b494-6870b3cc4fbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10197","predicate":"biolink:affects","object":"NCBIGene:8321","sources":[{"id":"urn:uuid:fe82a08e-e6e6-4eba-974c-ef69c7e2ada0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10197","original_object":"UniProtKB:Q9UP38"}
{"id":"52def80e-4d50-41eb-ae57-9b217439487f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2J3H5C81A5","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:04fdc49f-a4cb-4ca2-89b2-5f43b2964150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11135","original_object":"UniProtKB:P37231"}
{"id":"d34bf2da-90de-4fb6-bb8b-aaa30de16439","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111162","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:1dd1229d-c40c-49fd-912f-2b863e9d27fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4219","original_object":"UniProtKB:P42263"}
{"id":"70482713-13b4-4e29-ab48-21327ff663ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51035449","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:50d82b8a-077c-4a06-993b-127eea03ac1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10144","original_object":"UniProtKB:P51449"}
{"id":"9f35aa05-8932-477a-b750-39120c72b147","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32087","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:5dbff176-08c4-41c0-bd93-42ca3dd9ae41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1911","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"5606f809-7fc7-413e-bd96-72553bae468c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5298","predicate":"biolink:affects","object":"NCBIGene:842","sources":[{"id":"urn:uuid:eaa559d1-8557-4c67-8a78-7a5abcd2102c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5298","original_object":"UniProtKB:P55211"}
{"id":"d80cbff0-8abd-471e-ac46-96acb4233f0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755072","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:95cf1e46-1e51-44ec-af90-986950989ea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4043","original_object":"UniProtKB:P41231"}
{"id":"26ee9b4d-750d-42e2-8ec2-3096d2b1c1f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9865843","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:2c9e319f-bfae-497e-b1c6-77f801bff9bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1314","original_object":"UniProtKB:Q99705"}
{"id":"3272563f-0154-4229-8a40-0cdd0b3d7fff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135679","predicate":"biolink:affects","object":"NCBIGene:64636","sources":[{"id":"urn:uuid:a5e74a2f-0786-4320-a58e-faded7506e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1586","original_object":"UniProtKB:Q63384"}
{"id":"b5430551-2644-47e2-b7d6-0c6ef83c48cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2188","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:806316bf-22e0-4118-82e5-1ce901a58cef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2188","original_object":"UniProtKB:Q00788"}
{"id":"876ae0b5-ef13-47b4-a10f-6574be19ab32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10050","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:2ac7eb67-b3ab-49e6-8cab-39018dfd6539","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10050","original_object":"UniProtKB:P22001"}
{"id":"738b6645-6dd1-4a5e-b7a7-200d2a292ba5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7Y0IV7N95Q","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:5acf9e8b-1a00-4ee5-a33f-2231cce463be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9925","original_object":"UniProtKB:P12931"}
{"id":"de85c211-4db8-492d-9ded-ec56a29a948b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:08428e0d-b0b2-4539-ad8a-12362b678b1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q9Y210"}
{"id":"5ed12a41-1e34-44e3-980d-b65c116033b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2455","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:30f39395-2494-4ac7-a330-581e9b380518","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2438","original_object":"UniProtKB:Q8TD43"}
{"id":"887bd0c6-5d68-4f23-80de-7ce898c5e611","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118597685","predicate":"biolink:affects","object":"NCBIGene:23135","sources":[{"id":"urn:uuid:5be220d3-4a65-40c8-b544-ea30b9552cad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12807","original_object":"UniProtKB:O15054"}
{"id":"b1630233-6315-45eb-a674-819bf66438ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2029","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:98c19944-01d9-4afe-9963-2059418d0232","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2029","original_object":"UniProtKB:P35346"}
{"id":"f68103fa-e13f-4e8c-8a4e-4adae3a3eda0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10434","predicate":"biolink:affects","object":"NCBIGene:760","sources":[{"id":"urn:uuid:ff63ff32-ebf2-41b2-aac0-54a4a5e129dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10434","original_object":"UniProtKB:P00918"}
{"id":"7cdae44c-53ed-4617-9c83-a1f7f39273ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92814","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:e553028b-b6fc-4766-968a-f7f4313557c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3283","original_object":"UniProtKB:P0DMS8"}
{"id":"8255ff8d-21d0-45fa-afc3-79ab74ec7bab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13423","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:e7c02a61-203a-4b59-affe-d8e2896507e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13423","original_object":"UniProtKB:P61073"}
{"id":"690d1529-c2d7-4acf-97f1-73e5508ea7a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34968","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:3f7ed834-5211-4943-bf16-9304206d076b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4197","original_object":"UniProtKB:P31644"}
{"id":"c53f83ae-5d38-47e9-b1c3-cc81cfa7b6ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:8782a553-8f63-405b-a541-56f196aa4f41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P31388"}
{"id":"ae952fbe-57bb-4455-b032-9c23efcfc501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34654","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:fdf211ac-74af-4c2e-9e5f-911666056a73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2555","original_object":"UniProtKB:P22001"}
{"id":"034d9f04-8780-468a-acbf-8a026814e629","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70707","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:e484b84b-f6b2-424a-b72e-bfef64aa108b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7427","original_object":"UniProtKB:P31645"}
{"id":"bc599498-f4e6-4819-9bd9-26e319e935aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13502","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:e8b05f8d-6a7b-4495-8bb0-0495098d4308","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13502","original_object":"UniProtKB:Q9NWZ3"}
{"id":"a53e798e-d24c-4a8e-9e8c-12e6839cd874","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:30243","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:8fa271ab-4d90-400e-8ce0-78537b7e0c6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2444","original_object":"UniProtKB:O94759"}
{"id":"4d47990c-9eb2-4a3e-bcab-d3778ef81ca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890585","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:dcf25f62-9db8-4eca-97a4-5ae1a613e4ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2657","original_object":"UniProtKB:P37231"}
{"id":"d4977719-51c8-415e-8383-e3abda883d33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:3769","sources":[{"id":"urn:uuid:3a0e7d97-28f2-4e33-91c5-d9ca70204663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2416","original_object":"UniProtKB:O60928"}
{"id":"1db5dae6-cac6-47b9-91d1-c812f6a71a0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733035","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:3c799f61-1229-467a-ae27-3f64ac5f21f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11314","original_object":"UniProtKB:Q9UBY5"}
{"id":"21832380-112c-4897-a078-6e3c23103144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311114","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:70fb49ff-0a57-4e83-a73b-61176fdfd18c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:668","original_object":"UniProtKB:P30411"}
{"id":"c7267047-30b6-455b-9412-cc03fae922d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38565","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:10efe656-fae2-4ef0-abd5-e1773135aa9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2951","original_object":"UniProtKB:P04035"}
{"id":"cb8abaa5-b877-404e-a005-922d70e2785d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072553","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:e18427a0-5cb1-4f39-b33f-47fa255e8ce5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8956","original_object":"UniProtKB:P08246"}
{"id":"177132e3-a862-4b70-b11c-c48e159a3a1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1063","predicate":"biolink:affects","object":"NCBIGene:8322","sources":[{"id":"urn:uuid:c69b7e6d-11db-44ce-a80c-137a58ad7e09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1063","original_object":"UniProtKB:Q9ULV1"}
{"id":"20e53414-8872-4285-a801-d58fb4099336","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1326","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:ba9141b6-1d44-4c74-8a71-a76c0520d81f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1326","original_object":"UniProtKB:P33032"}
{"id":"1089c038-6a30-4fd3-a8e3-97f317d77e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73275","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:9555bce2-551a-4220-83d2-1853ea843a43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7349","original_object":"UniProtKB:Q92731"}
{"id":"619e41a5-9d8a-4979-a1b1-ad6e434a3935","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95037","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:dee5a43f-c495-4aad-b0ee-d65aaadbad89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5244","original_object":"UniProtKB:P34913"}
{"id":"1f344d7d-d6c3-4018-b900-2761f788a6cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N0A21N6RAU","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:b9a5e918-8b30-4ec7-9276-c2a1cbff82ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10432","original_object":"UniProtKB:P23458"}
{"id":"a9ea1c10-4764-41fc-bd0e-38556e8f66dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118613788","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:e08c927d-f42f-406f-9f22-67577cc24495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13765","original_object":"UniProtKB:P27487"}
{"id":"9ebaf429-f75b-4ab7-8337-57ccc2ec93d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9985","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:425f5c83-2598-4185-b3e1-6aefef136cac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:349","original_object":"UniProtKB:P08172"}
{"id":"4e133a29-31df-4a1a-a017-4e545db05b16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11698643","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:31bce5e6-2a17-46ab-950b-453ab17b5d1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6125","original_object":"UniProtKB:O60755"}
{"id":"664f463f-b895-4e52-9ecb-b0566cbee7a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813903","predicate":"biolink:affects","object":"NCBIGene:84876","sources":[{"id":"urn:uuid:81d6065d-3389-4ab5-a9b5-176355d00984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10042","original_object":"UniProtKB:Q96D31"}
{"id":"878beaae-b098-4356-85d7-6daf92fb5828","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8406","predicate":"biolink:affects","object":"NCBIGene:2719","sources":[{"id":"urn:uuid:1d53291b-adb9-4033-83f9-73e015834255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8406","original_object":"UniProtKB:P51654"}
{"id":"0c7bc672-1a15-411c-9b88-9149dbae8fcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0UPX3E69W8","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:10f9a658-4a4e-4c56-bcac-46d92203dafa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8370","original_object":"UniProtKB:P14416"}
{"id":"bb62b611-da96-4187-b4ec-4095260af1b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JZK8P9AG86","predicate":"biolink:affects","object":"NCBIGene:7511","sources":[{"id":"urn:uuid:722fda4a-ab4e-4817-9501-673c08c4c2dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8803","original_object":"UniProtKB:Q9NQW7"}
{"id":"7688732b-771b-4c5f-848b-3599b8df3c0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B06W426B66","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:86f69bb9-507a-40f5-866c-78dfd1e9efef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8108","original_object":"UniProtKB:Q12866"}
{"id":"6498ba98-4aab-4f47-860b-5dc363f551ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13838","sources":[{"id":"urn:uuid:32c84f24-27b4-4b4a-ac5d-0c58e51589f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:Q03137"}
{"id":"6dec69b2-a2f6-435c-a45b-dc2d980f5c2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91490","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:f01a4fcd-c362-488e-b1bd-f30cf5e130fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5570","original_object":"UniProtKB:Q9Y2T6"}
{"id":"0db782d2-c643-49b6-a8e5-14ab51de4659","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:6570","sources":[{"id":"urn:uuid:50f46fc3-1614-4ee1-82fa-00e0fd7632ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P54219"}
{"id":"213bbe4f-babd-41ae-a3d3-cc12696495ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10047612","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:8626703a-83c5-4ef5-8d53-a32e414e25d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1693","original_object":"UniProtKB:P41146"}
{"id":"46f17c4c-c094-4642-9c0e-93abe928020b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311148","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:b944d5ce-48dc-4f84-8d54-a009f7703927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:865","original_object":"UniProtKB:P32239"}
{"id":"b80b9a6f-1803-4265-994f-579d4aaf4b38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:5a050c7b-bfdb-4fe3-9053-f9993a5dcd8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P32304"}
{"id":"310bbf3b-fe14-4c93-b487-0696edf39c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34507","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:5bb863ae-050a-4cfe-a409-7a842b34050a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4113","original_object":"UniProtKB:P35523"}
{"id":"7a7e1ecf-2dbd-4b67-a20a-ff2e6d5a5aaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138828","predicate":"biolink:affects","object":"NCBIGene:25245","sources":[{"id":"urn:uuid:7b947689-e267-43b0-81e7-962a27fe58dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:679","original_object":"UniProtKB:P25023"}
{"id":"bd5f25bf-557e-4660-b870-1aea5d4f5403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:00c52a0b-644d-47ce-b9e3-b52cce06b3bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P28335"}
{"id":"2350fcf5-46cb-4224-8fc2-77fd76493fba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:21390","sources":[{"id":"urn:uuid:b58cf16b-187f-4d51-aef7-1248fa8c8881","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P30987"}
{"id":"2aa668c0-f32b-4f93-b768-c93d66092ddf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156068882","predicate":"biolink:affects","object":"NCBIGene:10721","sources":[{"id":"urn:uuid:c6fc5212-1687-42e7-8b32-0908fb459bbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12657","original_object":"UniProtKB:O75417"}
{"id":"91fed8d8-55f0-4ef0-9c18-1a76f184d03d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10389981","predicate":"biolink:affects","object":"NCBIGene:5319","sources":[{"id":"urn:uuid:cab8dac1-a503-4a97-b24a-1053d358a01c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8764","original_object":"UniProtKB:P04054"}
{"id":"95253d7a-a184-42cd-b227-282f33c1e86f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76283388","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:b9815e8c-07a2-4715-bf95-b988b9eeef06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13442","original_object":"UniProtKB:P35348"}
{"id":"cd1572a3-4357-42f2-9a39-3045863d404a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15713","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:d132712e-1b8e-4d21-91bd-92a273192ed7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1734","original_object":"UniProtKB:Q96G91"}
{"id":"0b489d1a-14a0-4006-ae99-7907ef6969ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441294","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:dbee9118-27f2-4fbd-876e-5c83697d21fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1862","original_object":"UniProtKB:O75311"}
{"id":"65b0fd60-f568-4a74-8a7c-0c7886e39596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9654","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:c11629cf-4479-4564-b46a-b74128adef95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:213","original_object":"UniProtKB:P41595"}
{"id":"264a9dda-0aec-42ad-8a48-90a73dc03b85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16236","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:6b522b63-f202-478a-b165-c511c2170599","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2299","original_object":"UniProtKB:Q9H1D0"}
{"id":"b32ddad4-ec6f-4384-922b-05bb14ced3ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8865","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:db7cdd45-c41b-40fe-9bcb-10d6e8af1338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8865","original_object":"UniProtKB:P41146"}
{"id":"c6f6555f-9eb1-4ba4-9dd8-6949fc88b7e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3655","predicate":"biolink:affects","object":"NCBIGene:1236","sources":[{"id":"urn:uuid:dc36664f-006f-4804-96d7-eeaa7df5044b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3655","original_object":"UniProtKB:P32248"}
{"id":"4fe8e091-5986-4db2-afa3-f94e181049a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44453397","predicate":"biolink:affects","object":"NCBIGene:817","sources":[{"id":"urn:uuid:1a3bb8c8-e28a-48b0-b426-90206c603ce9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8158","original_object":"UniProtKB:Q13557"}
{"id":"3925c235-16dc-4561-b252-5d1124a19181","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352891","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:273f08b8-c020-46f5-b6de-3e4331aa2cf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3116","original_object":"UniProtKB:Q02769"}
{"id":"00df5c01-d4c6-4ab1-a79b-baf5efead6c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:3770","sources":[{"id":"urn:uuid:ed0306ce-0414-4d80-ac30-28ade5c42e00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q9UNX9"}
{"id":"03bc8fcf-b9cd-4cf4-928d-34fcaa74a6bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11158623","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:cf2078f8-73f7-45a4-9675-f3bf57ef6ed9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6226","original_object":"UniProtKB:Q14416"}
{"id":"c2163fae-e67f-46cf-b5f9-662fb462c764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46899577","predicate":"biolink:affects","object":"NCBIGene:9407","sources":[{"id":"urn:uuid:645ebbb4-564a-43d1-97a2-ade967fc7493","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8670","original_object":"UniProtKB:O60235"}
{"id":"f50174c0-bf0d-452d-9fa6-d1005d0ad7bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117857370","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:58a8835d-7984-43d3-89ae-45b646790b36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12735","original_object":"UniProtKB:P13569"}
{"id":"c04ffaca-d21a-4b48-935f-e6d6c1141afb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53371736","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:bf8fb9d4-0d44-4464-9bc5-5415169d7591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9732","original_object":"UniProtKB:P18031"}
{"id":"1429d3d2-11f8-4655-aebf-42a35f0f7608","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8207","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:09f89ec4-4876-4484-982e-45a1508ac66e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:305","original_object":"UniProtKB:P11229"}
{"id":"e11c8003-d3b3-43df-921e-91634a22d3e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:d4c80a5a-5bd9-4e94-b4ed-33a195353ebc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P28223"}
{"id":"d74814dc-a6cb-4cab-ba61-1f3258a80a31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9998187","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:9ab806b1-dd4b-4dcf-a437-754738ee8853","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1353","original_object":"UniProtKB:P48039"}
{"id":"c5505b6c-9a9f-406d-960c-95ffe87767dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93359","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:031d7ccf-c40b-4f10-ab15-1af63d295877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1255","original_object":"UniProtKB:Q9QYN8"}
{"id":"afde57ef-71e0-483e-b74f-ca3086b260b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9951490","predicate":"biolink:affects","object":"NCBIGene:6416","sources":[{"id":"urn:uuid:fe42f304-219b-43e8-9648-da1535b0c564","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6006","original_object":"UniProtKB:P45985"}
{"id":"acc13cf7-0f09-4dab-9e20-9756776ff67e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156775102","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:8420cc90-79ec-4051-ae2b-c9f53a86c47e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12143","original_object":"UniProtKB:Q15059"}
{"id":"76b54675-0d1f-4b3d-b7df-42d5ec4d6605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156151242","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:ab37339e-f5ce-4d5e-96dc-349267f57aa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12116","original_object":"UniProtKB:O14744"}
{"id":"9d02c67d-cfef-48c5-b894-1dc1313f93bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:3172","sources":[{"id":"urn:uuid:e74dc570-4a5f-4982-ae84-e7629d6547f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1052","original_object":"UniProtKB:P41235"}
{"id":"981617c7-6da2-4cca-a9da-f9944531b089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1544","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:59e1ac40-1529-4287-94b3-693157e7580b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1544","original_object":"UniProtKB:Q15761"}
{"id":"55563782-a4dd-476b-bbab-a03d32fa3355","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92813","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:706acd03-90f6-45e9-9bd4-321bc82b6336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:113","original_object":"UniProtKB:P28222"}
{"id":"713d3dc1-d58b-4274-89b5-a1ff98542a11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1685","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:7afc4b6e-5f2f-4054-a30c-f47e4b7962aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1685","original_object":"UniProtKB:P41146"}
{"id":"82fe0a33-efda-4cab-a282-b3d74db7d0fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91455","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:11b76dd0-7a46-4aec-9586-d53ca129d879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5192","original_object":"UniProtKB:P05771"}
{"id":"1e9317ec-299b-4560-9b5b-5c3d71b3ae73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8481","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8e24de1a-840a-4bc1-981d-6a67d9409bb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:329","original_object":"UniProtKB:P08173"}
{"id":"81471b79-c28b-40a8-be17-55350e9a1231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78331","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:4a365be2-6cca-4c1d-b1f4-50075412bc2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9404","original_object":"UniProtKB:P06241"}
{"id":"b43015eb-77a1-4f0e-ab12-27110dba0df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:13609","sources":[{"id":"urn:uuid:dca9e179-1884-4757-97e0-3880e48dbf74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:O08530"}
{"id":"c02de9f6-807f-4522-b247-d2194e64ba14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:00e7f680-671c-458f-bbe0-ef41835d3080","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:Q9Y5N1"}
{"id":"aa933daa-4b9f-4a50-a81d-fe33f79923f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:d51a6e2f-7f9f-414d-9724-e1ca18fd3c2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P35968"}
{"id":"c204f804-3968-4a29-88ef-7f691788fc22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:e7e08b23-ae26-4aee-8a6f-5c9c913ca3b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q13547"}
{"id":"172c8209-81e8-4709-8947-1ac00da3627f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231350","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:9d667a03-0a49-4ac3-9993-aa6ff65317ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7793","original_object":"UniProtKB:P23458"}
{"id":"a595ce3e-c864-4148-be89-187994bf3c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57999583","predicate":"biolink:affects","object":"NCBIGene:80271","sources":[{"id":"urn:uuid:4d93f8f1-7eef-498e-8ea1-6a31f8224987","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9548","original_object":"UniProtKB:Q96DU7"}
{"id":"b7fe933e-6b47-4b38-a368-5749c118a3bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3440","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:f3cbe634-fe8f-4dfd-908c-1640001e8208","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2497","original_object":"UniProtKB:Q923J1"}
{"id":"08e92614-6159-4ddc-a298-320c0cfef11d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:5b570319-3291-47fc-a1c8-1ead6bb8b15c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:Q14416"}
{"id":"8a433314-99c4-4e66-934b-ed0886c73809","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3110E3AO8S","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:3b0f86e1-380b-4bb5-a10a-b6cdce8b330c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9309","original_object":"UniProtKB:P41594"}
{"id":"53c58daf-4592-4b75-a718-07b2e11ca765","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N5LJ2Z26C","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:2a3455a5-c762-43f9-87fa-4fa58c8fe46c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6977","original_object":"UniProtKB:O60674"}
{"id":"51b50c89-29fa-4eb2-928f-cb979a910fd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92090","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:98d1e961-cefd-4d9a-8a34-ca12ac2cf2d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:177","original_object":"UniProtKB:P41595"}
{"id":"77c34255-bdad-4c67-bc61-2a3c33307e4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N03P021J8","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:b24c8978-fbf8-48de-be61-69f162e72321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7954","original_object":"UniProtKB:O60674"}
{"id":"d18676dc-9bfc-4d09-826e-5a9ee94c5af5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164712","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:3ebd8a3b-e692-46a8-b276-986322521e10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2178","original_object":"UniProtKB:P30560"}
{"id":"0fd60a77-fe37-4f72-b214-ae0ef2e225a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947021","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:a84bd8c2-6acb-49d5-8241-1be10934fd16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3018","original_object":"UniProtKB:P51639"}
{"id":"2e0d132e-c3ba-4ec0-a71d-8d6adfbf5294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139349","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:fed2c33d-b33b-4636-b9bd-d0b6ba495eb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2443","original_object":"UniProtKB:Q9Y210"}
{"id":"36a4dcc8-9d6a-4d39-9517-c3ff81bc2b9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30853","predicate":"biolink:affects","object":"NCBIGene:3291","sources":[{"id":"urn:uuid:b72bf855-7166-4d52-9b63-a9a29501ade7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11264","original_object":"UniProtKB:P80365"}
{"id":"fab54ed4-eb6c-430a-91ad-7b4318a009ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JJC99KHGL","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:d70f6a7f-75fc-4f4d-a8fc-27f9211cfe0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11118","original_object":"UniProtKB:Q92769"}
{"id":"59fc7394-a72b-416e-922c-9d5b5552ee6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:794091","predicate":"biolink:affects","object":"NCBIGene:358","sources":[{"id":"urn:uuid:a21330de-60c4-4d9d-a510-0d95a55aaf0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13041","original_object":"UniProtKB:P29972"}
{"id":"659cb493-b4ee-40b5-834c-f9f1bdfed9ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D8UW47H17B","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:aef294a0-f191-400c-9a6a-f40def9ffc80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1379","original_object":"UniProtKB:Q13255"}
{"id":"d276b7b0-aaf5-48cd-b840-3e99546059ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9674","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:35a889ee-a506-40c9-98c5-f6afe427b38e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7313","original_object":"UniProtKB:P34903"}
{"id":"5b0c91c2-d6a6-4f61-acac-e918068edeb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155908677","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:5ffe5e5b-f62e-4e5f-8de1-39dc1a8e4cc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11554","original_object":"UniProtKB:Q02127"}
{"id":"f64069ce-3c4b-418d-92d3-618898f3b47e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6917952","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:a0f2ad82-be9d-4c14-9a7e-b17f76046a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2223","original_object":"UniProtKB:P30559"}
{"id":"dec684eb-50dc-488b-b920-8d19bf4d0143","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8435","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:558f7328-7f47-455a-916e-7b47e5185a54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7279","original_object":"UniProtKB:P21728"}
{"id":"73bd0693-db65-4f20-bf8d-a175e2e23824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9667","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:b3b52358-c43b-4688-8a1d-eccd098871fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2870","original_object":"UniProtKB:P04150"}
{"id":"63476da1-b37a-4f71-8f6e-44f6f4826cae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:d82a6b71-f18d-4bb4-88f8-f303ac1d9354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P29275"}
{"id":"1823cab3-dd3b-4403-8672-bd9921e7a03a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QQM82D8YUP","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:19ecbf78-a239-4d4e-b460-bfbad5828e4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:881","original_object":"UniProtKB:P30551"}
{"id":"9d7e9a85-f657-4c75-8f29-3cc1f8fd38a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1522","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:8c02002b-3b0d-41e3-bcd9-3344449fe0c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1522","original_object":"UniProtKB:P25929"}
{"id":"89caedb2-2035-4f0d-b9fb-441cb9fc5abd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75658JDG29","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:53de8bb9-0d17-49ee-8296-2562a1a60640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12720","original_object":"UniProtKB:P42336"}
{"id":"a7eebc2d-26ef-4530-9ad0-9283c408e8d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754992","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:e90a6a26-1f7f-4ef9-8d18-981754552ec2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:430","original_object":"UniProtKB:P30543"}
{"id":"49f45362-4a1f-42e1-a422-9baa59205f07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:7f0cd4c3-1ede-4992-adb2-3fd08741cb1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P21731"}
{"id":"a6fcf559-39d3-4841-92cb-9ac31af6be7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3738","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:317d0ff8-5faf-4da9-8a8b-48e27d188c6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3738","original_object":"UniProtKB:P49683"}
{"id":"578b18e3-0880-4c74-b064-b30781da0ff5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12533","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:3696dce0-b8aa-4e41-a431-ce7bcd709322","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12533","original_object":"UniProtKB:Q9Y210"}
{"id":"afe0010e-d533-4988-875d-1c457669a87b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35697","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:f1c789a4-6d25-4761-ba14-2500b1b26265","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3203","original_object":"UniProtKB:Q8TDS4"}
{"id":"87e45c51-f135-4d2e-bdc6-6bf867ee0513","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123777","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:74238cee-7bfd-471b-bfc8-794313585df5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1169","original_object":"UniProtKB:P30968"}
{"id":"88bdd96b-4a6f-41c4-9b61-15e074c65b37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59547990","predicate":"biolink:affects","object":"NCBIGene:84876","sources":[{"id":"urn:uuid:6d9101f8-a9e5-492a-b830-72efc54e2bbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10088","original_object":"UniProtKB:Q96D31"}
{"id":"90b93d88-59e3-4fe9-9274-9fc143c21964","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53339032","predicate":"biolink:affects","object":"NCBIGene:1786","sources":[{"id":"urn:uuid:a69d9d07-8261-44e0-883e-e86c9f619b5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7018","original_object":"UniProtKB:P26358"}
{"id":"517c0a8a-c3c6-4f8b-bed4-b6aee2de7094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2221","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:96459022-06f7-4496-9a24-1473c3fc1d03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2221","original_object":"UniProtKB:P30559"}
{"id":"c9d0b52d-1ee6-4230-b6a3-2e6b268a998e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56646218","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:c8fc2bb0-c3be-4747-b027-8cd746437e47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9580","original_object":"UniProtKB:Q14164"}
{"id":"4149d1e7-b408-4a7b-b982-7124c9b13393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135393470","predicate":"biolink:affects","object":"NCBIGene:5328","sources":[{"id":"urn:uuid:28895fcb-996d-406e-9009-16c1cc90768e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13072","original_object":"UniProtKB:P00749"}
{"id":"d0ea5bdf-c204-440b-bb0f-8e2188b9617d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T582DIM5A4","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:eba4571f-63ba-429c-b89b-b247742dc96e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9142","original_object":"UniProtKB:Q13822"}
{"id":"ce4a1f53-1be2-44fa-bf61-09782f61ff30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49603","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:25abe923-2eeb-454f-941f-1656326e8300","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5692","original_object":"UniProtKB:P04626"}
{"id":"7b656fbd-d1a1-483c-8643-fda9689eee4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:81025","sources":[{"id":"urn:uuid:fd505382-e31f-4439-b87f-c6b00f969162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P57773"}
{"id":"99eaec51-f45c-40f7-9e74-9913fa5ce305","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13936","predicate":"biolink:affects","object":"NCBIGene:5167","sources":[{"id":"urn:uuid:7943549e-6817-4b1d-bc96-541f5dc35c0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13936","original_object":"UniProtKB:P22413"}
{"id":"55b1a191-511b-4ebb-8327-302d3b3ed723","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17303","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:02383651-61bc-481d-a6fc-73816befe9df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1627","original_object":"UniProtKB:P34975"}
{"id":"e0acc61e-0a72-4e41-8c95-f1b33940050e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46836872","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:ee52d2a3-879b-4e8c-b7fe-53426d80de0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6238","original_object":"UniProtKB:P31423"}
{"id":"1914ba5d-022e-4872-9636-3d79933e603e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:2d67da28-7ef0-41a7-9ce7-fc11ca6dc814","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:P23979"}
{"id":"8dfa0980-ee45-4d5d-bb9a-c95d3a378e04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:8896d78d-70f2-4a91-b2b6-2de1efcc2b66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P08908"}
{"id":"11e8f47e-e21b-458b-bdbb-d688d0183298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8975","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:f981b17d-2ef8-4bce-8dce-f4b179f3424d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8975","original_object":"UniProtKB:P07333"}
{"id":"c0a9c3cd-93db-42af-ada4-f6b491c50b35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45480144","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:8b75e896-de15-4bed-a0b2-daf1aa318c67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7893","original_object":"UniProtKB:P12821"}
{"id":"3f34413d-6278-41fc-abf7-6612d90bff30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:9403e820-5a05-4904-a157-0a8f4f3e2864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:Q96GD4"}
{"id":"64194e87-5487-46be-8718-09c872936abd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125516","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:8a358f0b-b2d5-4347-9aca-7c9cbac5c85c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1582","original_object":"UniProtKB:P70310"}
{"id":"726af3fd-34ad-408f-92f9-e43920a9407e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14487390","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:4ac0871e-1ba5-407f-a360-0d91d122f697","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1447","original_object":"UniProtKB:O43193"}
{"id":"453fce4b-e398-42a9-a465-ea0c72eef7f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9963005","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:666a9c70-bc45-425d-adda-499772351746","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1679","original_object":"UniProtKB:P41146"}
{"id":"7316bfa8-b7c2-404a-84a2-01dfef429e59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:ce59d18f-4912-4348-ac2a-54ba2c11fbaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P61169"}
{"id":"6b0c9d60-2a63-418f-b414-3d86468255b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1351PE5UGS","predicate":"biolink:affects","object":"NCBIGene:57823","sources":[{"id":"urn:uuid:f32ed862-2fdf-4ffe-b982-90fe7ea550c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8361","original_object":"UniProtKB:Q9NQ25"}
{"id":"db385884-146a-4329-9053-00616b62d87b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30853","predicate":"biolink:affects","object":"NCBIGene:25116","sources":[{"id":"urn:uuid:776d5598-5e0e-425b-8433-01ce59c45519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11264","original_object":"UniProtKB:P16232"}
{"id":"8b87ecf8-ba69-47c5-8ecf-cd1e669a2d32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623352","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:511e394e-1954-4d19-8088-1f2e350ecaa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7926","original_object":"UniProtKB:Q9HB89"}
{"id":"8fd4c5f7-f2fd-4349-aa1a-dc59f346f1d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:11539","sources":[{"id":"urn:uuid:c503695a-0b53-40f1-8a87-92b208ff241e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:Q60612"}
{"id":"def01bce-9206-49db-a596-08fe54028f3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5707","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:df590ca5-c2c7-4bca-8f14-d37b9f37da28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:323","original_object":"UniProtKB:P08912"}
{"id":"ac46fc87-a526-40e1-a306-82eb89368d8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:272","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:9abe16f1-17a7-4763-9ca5-d8b1290581c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1647","original_object":"UniProtKB:P41145"}
{"id":"e73ec370-5165-42ef-8828-57495b8dad5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422751","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:cd8b71d2-1987-4b94-8752-8215411ebdae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12980","original_object":"UniProtKB:Q99788"}
{"id":"84c03f17-c082-46a6-a3c6-17e091c70e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3210","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:d21d30e5-319b-4d85-81c2-d1ae74b43b00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:144","original_object":"UniProtKB:P32304"}
{"id":"47e33e6f-fbb6-4dd9-bff7-1c8aaf7b77da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2063","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:34af2363-407c-4ceb-a5e4-d2edd39cb83d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2063","original_object":"UniProtKB:P35346"}
{"id":"a0ef1b67-7aac-4bc3-820b-347c8c11ac51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9855027","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:d86cca0f-8fc1-4580-9dc0-1cdae49e9e2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9342","original_object":"UniProtKB:P30968"}
{"id":"bd66e272-4de9-4b17-85f1-a35a437cfcd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4284209","predicate":"biolink:affects","object":"NCBIGene:8444","sources":[{"id":"urn:uuid:73462be9-458d-46a3-af01-e49c7210dbb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10081","original_object":"UniProtKB:O43781"}
{"id":"488cb373-f215-44fc-a8cc-946b13e69d43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167145227","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:ace3b359-cff5-420d-9538-102baf4aea90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13754","original_object":"UniProtKB:P50613"}
{"id":"8229b59d-0cae-4a84-9795-a8b2ce391780","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228412","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:20e70dbf-99e0-449b-9600-e7e5c057215a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12466","original_object":"UniProtKB:P59534"}
{"id":"4436b620-ffe0-4d40-a9b8-e192346be3c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:fece8156-364e-4f14-a66d-c11abefe7bf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P35462"}
{"id":"6bc0294c-f9c1-47bc-b5eb-8312bbe04880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X8EOD1X17Q","predicate":"biolink:affects","object":"NCBIGene:1368","sources":[{"id":"urn:uuid:202f348a-f10f-4ab1-a15a-78e938d09e43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8675","original_object":"UniProtKB:P14384"}
{"id":"39de47fa-5bf3-438b-b038-dbe474ecfa75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M6RN4LQ25S","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:68161dce-d70e-428e-aa4f-265050fda18f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11178","original_object":"UniProtKB:Q06187"}
{"id":"407cdebe-2fe0-4f1b-9115-e7fd256aeea0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:cdbed11f-4a3c-40e1-9f5a-b795b9a995f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P11362"}
{"id":"299ed0bc-d9f7-4b31-837f-72eb3fe7d97a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699448","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:f05afed3-8f72-42fe-9832-8d16fa0cc6e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11145","original_object":"UniProtKB:Q9NYA1"}
{"id":"b7f13702-ebbb-4198-a821-04ff2628e7a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:5a423058-a536-4b6c-a579-7e91300704f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P30994"}
{"id":"1446768b-a322-4432-ba09-9e2e03a8ef0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11960895","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:424a0819-2cca-4ee0-8bf7-6a4d464f10bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9304","original_object":"UniProtKB:O43613"}
{"id":"bdb0141c-a3c6-4c50-877f-4d5f3b99550e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57704582","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:4cff64b1-d2d6-4817-b7da-dd46a1c1e9f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9491","original_object":"UniProtKB:P21453"}
{"id":"70c32bae-c3dc-4b49-afa9-a3be5ce24aa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:dc6f7265-f6a6-40ce-864f-4d10a124d47c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:P46098"}
{"id":"14ffaf27-0f92-4c09-9e49-10c38cbe1b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129165016","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:59dcc7fa-30a5-4980-a084-01b52944384b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12350","original_object":"UniProtKB:P29597"}
{"id":"95c6e93f-195b-4204-9c07-89a73d24386b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12511","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:4a39b250-1bdb-40c0-bcd5-7570b9f07f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12511","original_object":"UniProtKB:P06493"}
{"id":"0acdcc4a-371d-429c-af16-b513be04d1b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195521","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:e33440fa-f650-49a3-8038-8d27bb13b0f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8167","original_object":"UniProtKB:P11309"}
{"id":"04dd51ae-736c-4e34-aedd-3ab117b1004d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92890","predicate":"biolink:affects","object":"NCBIGene:7535","sources":[{"id":"urn:uuid:fbbf91b6-db05-4f11-a9d7-236f73b5deb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5923","original_object":"UniProtKB:P43403"}
{"id":"aa836304-1c0d-4ae8-8b75-e14ebd3bc358","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:7587ac04-4e72-44a9-9eb5-b615ce91c164","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:O15379"}
{"id":"4a0e4467-68b6-4c42-a5a5-98c40c2f6884","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11994011","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:51120fa9-4292-4f48-b366-04e9a4a4c620","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1745","original_object":"UniProtKB:Q15077"}
{"id":"52b3c18c-506c-4bb3-9f58-835abd3bac87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54669868","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:524a1dfa-fc75-41ab-87c9-1247fcf48336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7516","original_object":"UniProtKB:O60885"}
{"id":"16742b43-bd30-4754-bd6c-d59a5e60c1ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2612","predicate":"biolink:affects","object":"NCBIGene:117018","sources":[{"id":"urn:uuid:315a32c1-58aa-48ce-8268-43d8e3bc5f79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2612","original_object":"UniProtKB:O08962"}
{"id":"62a39ac1-42e7-46a7-ae81-756459f0c8f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94104","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:06f137f9-3bc4-4258-88dc-3005b87b3bd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5922","original_object":"UniProtKB:P11309"}
{"id":"a3b8226c-bbb6-408d-8772-af9832e0626f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47381","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:ecc443d8-75ed-43f7-a8f4-b9062283c5b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2714","original_object":"UniProtKB:Q9HCF6"}
{"id":"07c5079c-5543-4251-8fa5-b7872f3c0c0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16264","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:3d466a5b-bf3f-48e3-8460-19ed297bacc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1779","original_object":"UniProtKB:Q15391"}
{"id":"9e1270b9-8289-49ff-9d61-4c0278372f1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94691","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:e6f13b28-470d-4acd-ad15-05d7c73d5867","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5715","original_object":"UniProtKB:P42336"}
{"id":"c91402f2-e3e1-4e69-b54f-44a5fa070fbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:64470f69-6cab-4a0f-b422-cef0e3980799","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:P51575"}
{"id":"bcfde7a6-4d1d-4afa-ad8f-183654498652","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60528","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:de1e2201-efee-42e9-9e00-fb14d2af6e49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:123","original_object":"UniProtKB:P28221"}
{"id":"b1a53862-c27e-4f07-b655-f1c6670238a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321155","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:5bdee5f8-4fdf-4eff-98fe-f3cba1e44fd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10147","original_object":"UniProtKB:P29597"}
{"id":"b36d74f5-3806-4825-a7d1-ae1a95cba0de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19DG7G1U5Q","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:603222cf-2d97-4e4f-909b-6e1cad620535","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8917","original_object":"UniProtKB:O00329"}
{"id":"6f399665-5b92-405f-9461-66accfd482e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LMQ24G57E9","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:9b673f80-5f12-4662-b9c1-bb4cd1cdfe37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11648","original_object":"UniProtKB:O43614"}
{"id":"1afe9658-0b2d-4233-abd5-dc40aa949fe2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1452","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:53c50ee7-48ab-4989-8485-4a6833fb7453","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1452","original_object":"UniProtKB:O43193"}
{"id":"dfcdea82-569c-4153-9294-23f64e8a011b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8997","predicate":"biolink:affects","object":"UniProtKB:P01854","sources":[{"id":"urn:uuid:150cc945-44f8-419c-99b9-cb22ebf3144a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8997","original_object":"UniProtKB:P01854"}
{"id":"89ebd01a-deb8-4cc1-9f88-0621e262716a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:814fc63b-67db-4a5d-bff5-d076dcc519a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P28222"}
{"id":"1974d0fb-d7e2-4f6b-a7aa-a9b1ce5fcc43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:440a33d0-cc16-4951-8016-0526cc00e65a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q92769"}
{"id":"8bf8fc56-b236-4b93-a507-a65f2ec967f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13458","predicate":"biolink:affects","object":"NCBIGene:6768","sources":[{"id":"urn:uuid:f283ccbb-c7eb-43d8-8537-36333fdec7ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13458","original_object":"UniProtKB:Q9Y5Y6"}
{"id":"6fa7bd06-b764-465a-906d-3e3fafbd2752","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441294","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:1ba3f5e4-3ee6-4eca-9366-20e443074718","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1862","original_object":"UniProtKB:P46098"}
{"id":"2553a609-627d-40bc-aadf-18a98441fbfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231407","predicate":"biolink:affects","object":"NCBIGene:948","sources":[{"id":"urn:uuid:2e651a08-095d-471b-9ee5-a7da16ffb090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10588","original_object":"UniProtKB:P16671"}
{"id":"69bb79dc-e8a9-47ad-89f3-3ab798a93c92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40751","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:0f9d35db-4867-44da-976e-9f54f97f4df0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4450","original_object":"UniProtKB:P35368"}
{"id":"c43b6532-bb13-4223-9936-4decd31640d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:348010d9-e87a-475a-8304-1c00103ac847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:P47211"}
{"id":"dadf548c-6973-4750-8be5-430472a1e6aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232752","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:8964c7b7-96d5-4590-b1ff-793eb1bc8266","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8241","original_object":"UniProtKB:O60341"}
{"id":"83e77966-fc6c-49f3-ba21-9a5745fe3e5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5134","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:d27db828-bdad-4643-9527-ce4c8d585995","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7080","original_object":"UniProtKB:P08235"}
{"id":"18982978-3ba8-4573-b989-2b9f4718b8f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6444","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:cc4ee7d3-63ee-411a-a168-067b4071307e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7595","original_object":"UniProtKB:Q14957"}
{"id":"21b79eac-7989-4aa8-b9a1-0bf4d822eec4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:168543","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:ac8a9483-b228-4073-a09a-061087325c8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1930","original_object":"UniProtKB:Q62053"}
{"id":"1c75b231-7298-4e96-a6e9-69c6c523af6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185642","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:9f0ec12a-3c60-411e-adbc-ff6eadc5b40e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1897","original_object":"UniProtKB:Q13258"}
{"id":"64c968a1-29df-44fd-99b2-151f1ef46e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1295523","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:fc8d01ad-4a7a-4e56-95aa-0f3c337932c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10039","original_object":"UniProtKB:Q8TD43"}
{"id":"d07417cd-66a2-4f45-9a19-662941af2fda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49375","predicate":"biolink:affects","object":"NCBIGene:23387","sources":[{"id":"urn:uuid:349a1a18-0109-4f9f-b5b3-f790b211653c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5678","original_object":"UniProtKB:Q9Y2K2"}
{"id":"d7b881e4-5dac-4b20-ad72-14016813ec3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7567","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:4ceda589-9ed5-47de-b267-8c2e4bc8c428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7567","original_object":"UniProtKB:P15389"}
{"id":"0de58841-c722-42bc-9523-72010d99804b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:189762","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:aadd01e0-5a71-4e3c-96b2-e3e16f49cd0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1764","original_object":"UniProtKB:Q9H244"}
{"id":"57c4bcb4-f161-4ec6-8a6a-3a529c90c89f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5758582","predicate":"biolink:affects","object":"UniProtKB:Q03059","sources":[{"id":"urn:uuid:df01c353-96f1-4dfe-a1b6-c2933341bfe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8807","original_object":"UniProtKB:Q03059"}
{"id":"787a5fcc-cb9d-4c50-9ed6-5702db70db8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4608","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:d6cfb410-bd1d-43b8-b3c4-8d07b9c7aba9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4608","original_object":"UniProtKB:Q05940"}
{"id":"4911404e-ae9e-4888-a104-5be8f3ea670a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321160","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:bcc8f87d-0dd5-48f0-9216-9e3c898030f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10157","original_object":"UniProtKB:P23458"}
{"id":"c4084406-9ccd-4643-8f0a-bf7d0432e43e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36795","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:069e2b3b-b437-4c5c-934c-ccbfcb1048d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:202","original_object":"UniProtKB:P28223"}
{"id":"f415bbd2-98ca-4b3a-9cbf-bacc5026d0d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F0LZ415Z3B","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:f8f3733b-2003-4ccc-98ef-08e665abb3e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11330","original_object":"UniProtKB:P0DTC2"}
{"id":"788cb930-bbc0-4295-b106-0d8ca2b8af11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53246941","predicate":"biolink:affects","object":"NCBIGene:6197","sources":[{"id":"urn:uuid:31c9db0a-cca3-4aa0-9410-a8ad86444371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8039","original_object":"UniProtKB:P51812"}
{"id":"ec77270f-48b3-4aa4-a70a-9d104e9884f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:912","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:ea7e3202-f4b1-4c25-ba16-d92b8fff1907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:912","original_object":"UniProtKB:P47866"}
{"id":"67160061-6370-4958-94e5-8dd3a96df54c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659801","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:175b53a2-4b7a-40a6-941a-ff14098f6f5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6346","original_object":"UniProtKB:Q13255"}
{"id":"034310ac-81b6-45cf-b403-8839da68ea54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42604859","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:637aba15-a47e-4547-b5be-5ce0876681e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9467","original_object":"UniProtKB:O43614"}
{"id":"151d3a7e-aea6-4bb4-aa53-fb8b9274249f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3TY57MQ4OA","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:c766652b-a6f7-4379-895b-ef75a58ba9f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2202","original_object":"UniProtKB:P30559"}
{"id":"3103f492-bed5-4f9a-86e7-5d64c853c642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3171","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:7232109b-916b-42ab-9e63-0934456cde01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1603","original_object":"UniProtKB:P33534"}
{"id":"c76ecd5e-39f8-44dc-a00e-6bbd74de0e3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118016229","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:e79dbaf1-ebbb-419c-99fa-6f7b8588577c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11224","original_object":"UniProtKB:P29275"}
{"id":"04d2fd44-a914-49e5-8cec-3ad1a09be7e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2904","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:c320dd97-4c74-4f3d-9a1f-00d8e82c6f10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:548","original_object":"UniProtKB:P07550"}
{"id":"1c61d92a-5216-41cd-958e-549e51271e9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136007","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:1eaf7ebb-e55d-47b6-b2f0-68ba1e5a06e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7563","original_object":"UniProtKB:P41145"}
{"id":"f600b6a8-e1b2-460d-8331-c0bfabdd15c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108595","predicate":"biolink:affects","object":"NCBIGene:8824","sources":[{"id":"urn:uuid:eaaeb650-9e07-46fb-927d-106074801ba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13771","original_object":"UniProtKB:O00748"}
{"id":"d7b409fa-9afe-4d81-a4de-dcfe4eafdb07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:35a7bba6-34c2-447a-ba64-062bc6b8fd23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:Q13639"}
{"id":"149e3df9-4acb-4128-b67c-cac80c3c1af9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9851","predicate":"biolink:affects","object":"NCBIGene:8879","sources":[{"id":"urn:uuid:a7da50da-1358-425b-a9df-51bdb748f805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9851","original_object":"UniProtKB:O95470"}
{"id":"5a67ebc7-fdea-458f-9b45-aa5ce6618b14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189647","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:41796335-aad2-4936-b579-bcdbfede4607","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9560","original_object":"UniProtKB:P55085"}
{"id":"caa48b60-88f2-48f5-81cf-d0ce274f0bc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368938","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:292afdb4-4b42-48a4-9228-83aba82b4c96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12216","original_object":"UniProtKB:Q9Y243"}
{"id":"cd583c98-d058-4238-bd7b-06f30acb7ec9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:e34fda33-8273-4cb0-9269-2860561b94c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:Q7RTT9"}
{"id":"4abbbf2b-7c17-43b6-93b3-7b0636f500dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OVW60IDW1D","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:79b48eeb-5a91-44c2-8431-e09010aa1521","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10096","original_object":"UniProtKB:P48736"}
{"id":"c2506593-9d72-439b-9278-f5cb33f916cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:4e256270-4b37-4e12-b464-9f558ed601b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P32305"}
{"id":"f533c429-0b97-41bb-bed3-ba01233fb0e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K911R84KEW","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:8ce38ceb-7b91-4d8a-8426-bf880b799f18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8686","original_object":"UniProtKB:P04626"}
{"id":"b0fe2598-a2d2-4319-a54f-0765ea13b0f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:7cedc7f5-7144-4edb-9063-272d26992906","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P47898"}
{"id":"ffc2630c-2e35-4c50-9a4a-7cb2fad4f862","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755142","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:8454b2d3-6ea2-46f0-a0fe-6439b988bd2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5652","original_object":"UniProtKB:Q8TDV5"}
{"id":"03178c3f-4948-4bf3-a1fe-6d732dd4de4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78320","predicate":"biolink:affects","object":"NCBIGene:243270","sources":[{"id":"urn:uuid:1a71b34c-a28b-4b4f-a036-20178e00fd21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2932","original_object":"UniProtKB:Q8C131"}
{"id":"9a578e02-01ba-4723-897e-323d79c3868e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6426760","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:a556659c-cfe2-40fb-b234-5c8920dcb1a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:114","original_object":"UniProtKB:P28222"}
{"id":"6def5352-f814-4380-81ae-08c43531dbba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24937012","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:2e143398-ad84-4926-b96d-921c8685f3c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8242","original_object":"UniProtKB:P42338"}
{"id":"c3f702ad-e951-497f-9a76-7e4107f52f41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6110","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:2deb6f42-e99e-4bc3-88cd-e7b0401689c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6110","original_object":"UniProtKB:O43603"}
{"id":"3b22ec5a-0b66-4a3c-8db4-83c149df4313","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993637","predicate":"biolink:affects","object":"NCBIGene:7468","sources":[{"id":"urn:uuid:83205ed8-500f-4980-acaf-9e0df3265561","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12352","original_object":"UniProtKB:O96028"}
{"id":"031d60a8-329e-4a9c-ad73-76050345ba62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449663","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:f6010a34-e457-470c-b60e-082b31ea9589","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1264","original_object":"UniProtKB:Q9Y5N1"}
{"id":"ceb6ce42-819d-41ee-9324-11a08c61b848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OEP8JJ3OZR","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:e6044b35-6910-4a4b-a887-1a48d3ca9e60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9425","original_object":"UniProtKB:P48736"}
{"id":"f801ea5b-5789-4ad3-a556-09bbd7836e8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12502","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:75148d4e-1a66-4e50-aac0-ec1eb5a0f518","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12502","original_object":"UniProtKB:Q9HBX9"}
{"id":"06c862be-2b13-4500-b456-d8590cdf6ccb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CW55R761RE","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:dd2965bb-d12a-46e3-a52c-b479f7d44a10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:290","original_object":"UniProtKB:P20309"}
{"id":"6616cf25-b9d3-44bb-a5a9-812d4ccc6197","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:9cfc9695-5c9d-4478-9fd2-72033cc79d48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2491","original_object":"UniProtKB:O35433"}
{"id":"c3430ad2-bd5e-46b6-9a70-12308b0400dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25074458","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:f0b9470f-d6e1-4f2f-9000-20649ac4ec9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6240","original_object":"UniProtKB:P25090"}
{"id":"5ecad4ad-9976-4a99-bcfa-747b659d0a09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11751175","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:83d0bba0-f537-4707-9806-38993b45d5fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6265","original_object":"UniProtKB:P25090"}
{"id":"70619495-fab3-4475-b4f8-c9d503f8878e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1795545","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:a93f8957-342d-433b-8759-adfdbca1c870","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1414","original_object":"UniProtKB:P35349"}
{"id":"96e99a50-ec32-4286-a6be-57d534edcf8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5487427","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:a025a1c8-9734-465f-bd19-48401bef0b6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8592","original_object":"UniProtKB:P08172"}
{"id":"2153f730-cd40-4138-8d25-7ba1bb6fc0a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231951","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:b360ad9f-b751-4385-a811-da174fc7c226","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12064","original_object":"UniProtKB:Q12809"}
{"id":"871316f7-9c02-4e74-b156-98a6c391ccbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DL772G3NN7","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:e3f17be1-2aca-4755-b6c4-a2a42c9729d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13213","original_object":"UniProtKB:P06239"}
{"id":"6e779ddc-3136-431c-849b-1cdebfd03d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3N422P20J8","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:b4bb3937-e1a3-4e56-b8f7-d7cab50c444a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4368","original_object":"UniProtKB:P34903"}
{"id":"e4325e92-f6b7-4679-b165-39cc1eb78a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10082","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:ff0fc017-8944-4723-8adc-14d8e242380c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:517","original_object":"UniProtKB:P18825"}
{"id":"575d6ece-abc6-42f1-8ed7-ff962a9a59f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138471783","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:4351c2ce-58d8-441b-a8db-6cb0210ae162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12527","original_object":"UniProtKB:Q9UL62"}
{"id":"80f9608d-a4cc-4455-9d5b-0ae52b2d5c1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73659199","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:3360efbe-2a1d-4b10-a638-fbe54efd89a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10234","original_object":"UniProtKB:P42336"}
{"id":"9c95075d-c4e7-4406-ba2e-c230b8d2631c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D17QSK5F4B","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:2f271b3e-0d26-49a2-97f2-1dd8530149d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3357","original_object":"UniProtKB:P35408"}
{"id":"bf609438-20d1-482e-bfc6-779eb693949f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:358","sources":[{"id":"urn:uuid:2855f678-66e4-4923-8973-4d3a5ce90b9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:P29972"}
{"id":"6f7e731e-8c03-4320-a255-113ca1d74ede","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87237","predicate":"biolink:affects","object":"NCBIGene:1454","sources":[{"id":"urn:uuid:239c599d-9ac9-4da0-aa2f-e3181573508b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8050","original_object":"UniProtKB:P49674"}
{"id":"2cf9f1eb-d531-44bf-99ff-727325e48e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53339032","predicate":"biolink:affects","object":"NCBIGene:84444","sources":[{"id":"urn:uuid:801331e0-ea15-430b-ab2a-efa417277559","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7018","original_object":"UniProtKB:Q8TEK3"}
{"id":"5320cbd6-3e9d-422b-a74b-b2e058287f52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8331","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:186cf919-e61d-4ba4-aadb-fe7c022648ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8331","original_object":"UniProtKB:Q8WXD0"}
{"id":"a137fa9a-35d9-4a1a-86b5-d95a27dad046","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93239","predicate":"biolink:affects","object":"NCBIGene:23081","sources":[{"id":"urn:uuid:7f5ff821-0c3c-4b84-a57b-6154220500c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8230","original_object":"UniProtKB:Q9H3R0"}
{"id":"1fe3cb8e-3cc5-4e1f-92b1-a38fbe885ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23730136","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:38ec22c1-60f3-4c7a-a336-f8a6edad6989","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3152","original_object":"UniProtKB:P14324"}
{"id":"eab418dd-9683-4f82-8166-63698ac4e141","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:594754ce-5a52-428d-9766-cf831379c96a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q9UQL6"}
{"id":"ceb33b80-5480-49d6-9876-c72e4fa4192c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2707","sources":[{"id":"urn:uuid:0e42c551-75ef-4bfc-9810-9cfbb4d6c1d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:O75712"}
{"id":"d148a337-3f4f-4afc-b069-52d358adfd86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:b73138e4-7c93-4c72-b0d6-245d6f808b78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P28222"}
{"id":"f2e7c1ff-be09-45d1-ad77-76f1769fca76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60528","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:0f5b9525-348f-407b-b16e-3b13e79600df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:123","original_object":"UniProtKB:P28566"}
{"id":"518ebd3d-7980-4bfa-b851-cf832bbf7325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:f9943c2b-0378-4650-ad80-ce3268dedb69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P41595"}
{"id":"dba0af27-92e4-4bb9-a579-bfc34f267a53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66554294","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:3e0f2851-e23a-4d77-bb29-68ffc114a996","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9603","original_object":"UniProtKB:O00519"}
{"id":"20396b74-b4c0-4ead-b4ea-cea7c982db9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:ac9113aa-4ef0-415f-ad07-9fccb4c94909","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P06241"}
{"id":"46a3c0ea-0138-48d8-8593-3fa64a97c6c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6954180","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:e0c9ee87-0b66-435f-a06f-4740378cca02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:286","original_object":"UniProtKB:P11229"}
{"id":"501aa03d-c499-49eb-9e6a-1e3235019a5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755017","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:ae7d7ed2-cf25-4c6c-b06b-b18f3bd91197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1843","original_object":"UniProtKB:Q62035"}
{"id":"0e279481-224f-42ac-8b8b-8e91798f0b5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8268","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:44038e7f-5d83-4f61-9e06-5d9c02df37aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8268","original_object":"UniProtKB:P11836"}
{"id":"44a7be73-d27f-4e25-916b-6a1ae20a5e73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124226","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:869361fb-ecb7-4356-907f-b34d3cdde39f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:322","original_object":"UniProtKB:P08482"}
{"id":"9e4a5716-f410-4f5f-b399-79f6f6441c83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M7FHF24Q22","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:5f808ab4-f51a-4e5a-ad34-5278f58f0779","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:195","original_object":"UniProtKB:P28223"}
{"id":"e855ed1c-61bc-47d3-90dc-e065d5205f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8977","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:8d946a77-959a-4eed-8bc6-13ff7be442f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:189","original_object":"UniProtKB:P28223"}
{"id":"77516261-edad-4509-80bc-0c75db2e5b03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15552","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:9a80eab5-f7ab-479c-9dfe-87f256646e34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1915","original_object":"UniProtKB:P35408"}
{"id":"5e862c32-26ca-4ed5-938a-ea70ae543f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52172","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:ba7deb69-b069-4fc2-8162-f5ff4bf934d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5697","original_object":"UniProtKB:Q16832"}
{"id":"dcad3d85-7bba-4334-9b57-ad113b651f26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146425702","predicate":"biolink:affects","object":"NCBIGene:50814","sources":[{"id":"urn:uuid:de1b58be-c37d-473c-aea5-2c84284e3e42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13566","original_object":"UniProtKB:Q15738"}
{"id":"21537437-2b05-4223-9294-8a6e5e3a74fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167695","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:da2c5915-b45d-4ba4-b4a5-278b32f7160a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13430","original_object":"UniProtKB:P0DTD1"}
{"id":"70fb31bf-35dd-44c1-9642-2e738f628101","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1018","sources":[{"id":"urn:uuid:867f260a-4310-464c-8759-4e4f087ea611","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:Q00526"}
{"id":"251bd7d0-887c-4582-a93a-94ff3ac8f934","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44134520","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:2a773afb-f526-4e96-8dc6-ece37acd21bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2257","original_object":"UniProtKB:P32241"}
{"id":"aac7e4a2-8d97-4126-9cfa-76cab619fdb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169448380","predicate":"biolink:affects","object":"NCBIGene:6595","sources":[{"id":"urn:uuid:2fd4ab6e-fc4e-4196-9369-44c811bac544","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13104","original_object":"UniProtKB:P51531"}
{"id":"5c248206-08a0-4aca-bce2-08e80ee5f1a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7XL5ISS668","predicate":"biolink:affects","object":"NCBIGene:943","sources":[{"id":"urn:uuid:2bc9925a-4f25-4a38-9a07-dcc2ca400cf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6772","original_object":"UniProtKB:P28908"}
{"id":"fa7bbfe1-4828-4a3a-9fd8-d0551216f093","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y6TH2I6W99","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:d2a03c7a-2be6-4d98-8590-db186280e0d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4230","original_object":"UniProtKB:O35433"}
{"id":"048299b0-9d90-432b-ac1e-9d4d6a8282d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656733","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:87476264-a37a-4532-b6b0-8d8f2bdfc107","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2320","original_object":"UniProtKB:P70604"}
{"id":"52ff5a87-2e22-4440-abf5-a66ad4fa241f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4369380","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:2e702c8f-2bf2-4649-b219-27a70567674b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5278","original_object":"UniProtKB:P08473"}
{"id":"160f7641-b8be-457a-bcdc-e65fe81bf875","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52952605","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:ff4f0f85-9866-4838-9725-2a185033553a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5902","original_object":"UniProtKB:P41231"}
{"id":"aed05899-13db-418f-8900-442d1793e2df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:d2eec1dc-e8a6-4d7d-b1e8-dfdc393e01b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P28335"}
{"id":"61683da8-4e9a-46bf-bfbe-a59b29c37ca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6BTT8VA5Z","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:52e4452d-f68f-46f4-ac32-42c16ae807f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4460","original_object":"UniProtKB:O43613"}
{"id":"984c6a22-a2f8-4939-b717-6a1e68da9c47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230921","predicate":"biolink:affects","object":"NCBIGene:10988","sources":[{"id":"urn:uuid:ded7d266-3134-469a-b034-de0b9874518e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8445","original_object":"UniProtKB:P50579"}
{"id":"cc4b85ad-c8c7-4240-b301-19466d2e23db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126481870","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:da662d70-7eed-4699-9a6c-fbb9f7c4acc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12282","original_object":"UniProtKB:Q15910"}
{"id":"ae8d1bb7-391c-42e8-8dbc-608e9000568c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:7f700457-d80f-48a7-908f-653608979eb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P14416"}
{"id":"7a3144b0-7154-4f27-ad79-a23196a7f510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:abe2ba02-a581-4098-8316-a0fc965924ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P35368"}
{"id":"7b5bf9b8-dfe7-482e-b79c-1cfe52e13359","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GEZ43HM6NW","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:35314e71-9746-4132-8bc6-d7fcd13cda6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11659","original_object":"UniProtKB:Q05655"}
{"id":"2f58b56c-911c-4f9c-bf6b-e190aee319d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:db4eacd2-7876-4fd0-b991-1a890f1dea6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4360","original_object":"UniProtKB:P34903"}
{"id":"3331ca85-a3ae-4960-9849-d9e60bb612f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9935197","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:3db4979b-f600-44ee-a281-727eb2ac56c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2688","original_object":"UniProtKB:P55055"}
{"id":"0db3f712-1759-4075-9f6e-8779f871652d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:c4e96d05-53b3-4801-a5f7-808cd096e782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P32305"}
{"id":"d0fd7439-a950-44c9-95d8-056ebde340b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95129","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:9be20be7-382c-4df0-a23d-00844be7e397","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:240","original_object":"UniProtKB:Q12809"}
{"id":"14249dc1-208b-4fd3-a328-6c7f31b671b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:665685fc-2558-4fad-a30f-0f1b24e4bf3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P08908"}
{"id":"ad3cecc3-f087-40e2-ad9e-84d66b962fc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7307","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:a7bf1537-e5fb-41aa-82aa-2cda366ef7aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9520","original_object":"UniProtKB:O60885"}
{"id":"720d16a4-a137-4d27-a3cc-fcdf7c82daef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11841193","predicate":"biolink:affects","object":"NCBIGene:246","sources":[{"id":"urn:uuid:c84d197a-9c40-4dc3-b6d7-ffe9486b7428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9141","original_object":"UniProtKB:P16050"}
{"id":"ce317a9f-a8dd-4629-9c04-fa0b15550b5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:7397e044-a799-46e9-b485-aa0f74e5af67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:O60755"}
{"id":"eb902777-b4b0-4436-9357-29ecdcb47a97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:644212","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:bbc292f8-4f76-46fd-b9ab-69336d7748d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1344","original_object":"UniProtKB:P48039"}
{"id":"f1465c2a-48ac-4158-a9e6-e3cd4ea44179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182364","predicate":"biolink:affects","object":"NCBIGene:658","sources":[{"id":"urn:uuid:4c569396-1071-48b4-bca4-680de7d662fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8144","original_object":"UniProtKB:O00238"}
{"id":"607e92c4-bae0-4963-acb4-bf87a072d432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947047","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:bc9ace5d-78cd-4c0a-9fa1-951966928787","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2975","original_object":"UniProtKB:P51639"}
{"id":"371dc1ea-6324-4b95-862f-87b88b8399d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49375","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:4e069e41-c904-41ec-8b88-694baaeba377","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5678","original_object":"UniProtKB:P00519"}
{"id":"cccacb14-e095-4273-a7b3-93b307ba6962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:e6540659-3fce-4ad0-b24b-ea3866a05503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P28335"}
{"id":"1daa6344-0ab4-4e21-8219-d9e42a558083","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129257213","predicate":"biolink:affects","object":"NCBIGene:56827","sources":[{"id":"urn:uuid:c8a4c7c4-1cbc-40cb-8fb2-28a8a18534a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10537","original_object":"UniProtKB:Q9Z0Y8"}
{"id":"5e5d44bc-d115-4b11-965e-942f9759e6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4345957","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:e9522789-bf78-4106-ba13-adb7ba9493a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:613","original_object":"UniProtKB:P21729"}
{"id":"38b07683-f5b1-428a-bd97-5e92fa2db298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131358","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:9f90cb64-115c-4a44-bf0b-9d9874ab07a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3289","original_object":"UniProtKB:P30542"}
{"id":"699d5e9e-23e0-4ec3-9b50-8e1ebc51d572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c2a8381a-7189-4b87-a7bf-2fccbd101645","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P28335"}
{"id":"cd33da3e-8488-4c27-9cf4-99682d95c678","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:14FDK6ISC9","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:c54913d5-ddd7-43e3-9512-5e5d69ebf9ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11727","original_object":"UniProtKB:P28482"}
{"id":"a70770d4-501f-47c8-bc38-afb67fddc292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71952","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:0624c0b6-2b00-4804-baa2-e62ae4b88773","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7950","original_object":"UniProtKB:P42336"}
{"id":"8e7d154a-4ca3-46d2-ac92-8fc2fe33df1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:64177","sources":[{"id":"urn:uuid:f013558a-a2d3-4a3f-a349-b1dc7c07ba8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q91WD2"}
{"id":"cb4071a6-eca9-44a7-8365-dda4fedfff7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9926882","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:4f28e258-cdeb-4bc8-9881-b4f9627e5414","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:444","original_object":"UniProtKB:P29275"}
{"id":"94a941b0-1d57-49d3-9597-905ab555a1fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:064593a7-678b-4a27-9139-109d6261fea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P51451"}
{"id":"211973b0-cbe3-43b6-9db3-b2b44aaa505b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:671c06d7-7b0b-4de0-a7dd-05f2174ed56f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P43115"}
{"id":"a16f03a2-ab9f-4a41-9124-887d55296276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42371","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:1f146e95-f226-44fe-926a-6502cf2f9f51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2822","original_object":"UniProtKB:Q92731"}
{"id":"104d7977-a6f9-463c-9937-34beecac3dd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110423","predicate":"biolink:affects","object":"NCBIGene:63910","sources":[{"id":"urn:uuid:c342bdfe-8636-417d-98ef-e16133b2dbb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9605","original_object":"UniProtKB:Q9BYT1"}
{"id":"cfc38010-8628-460c-9cac-07e4731e7986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:298cabf3-b7a0-4caa-a065-3d91bd341ad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:P57789"}
{"id":"4ea83691-92fb-4c47-ba3b-875e68bfc71d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755215","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:637158f0-bbb1-4787-b1b5-311092186116","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6370","original_object":"UniProtKB:Q8R455"}
{"id":"4ebf8282-6c8f-466f-9674-9a43434164f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:c9c3cd16-391a-4e01-b549-06614189542f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:Q16539"}
{"id":"51c9e5e8-4a69-45f0-ad15-e41c5b252bc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232302","predicate":"biolink:affects","object":"NCBIGene:13850","sources":[{"id":"urn:uuid:2386f793-40c9-4a32-84ef-0c1683d78458","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13112","original_object":"UniProtKB:P34914"}
{"id":"f89ac55a-7dd8-4f8b-8112-ca173da1592e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8093","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:f8bd974c-e28f-4334-a6f3-a355a09b48c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:485","original_object":"UniProtKB:P25100"}
{"id":"63697c67-6888-407c-94de-581a387568c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4856","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:8c493943-1e96-42e9-9e86-fb9d28d41aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4856","original_object":"UniProtKB:P16066"}
{"id":"dde30cde-889c-41fe-8eb8-10ab5704246f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755225","predicate":"biolink:affects","object":"NCBIGene:6555","sources":[{"id":"urn:uuid:972c2cf1-adb0-4eeb-9d56-3e6a74e8b5af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6530","original_object":"UniProtKB:Q12908"}
{"id":"92902fad-e3da-40c7-968a-1a46be314c96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5017692","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:5bdf0d76-5367-4e53-bd25-adfa5134259b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8775","original_object":"UniProtKB:Q6DWJ6"}
{"id":"259acefd-ecaf-4c42-97c2-bae918dc2e93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169292289","predicate":"biolink:affects","object":"UniProtKB:P49356","sources":[{"id":"urn:uuid:9b032952-97fb-4279-9c45-ed115901e834","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13803","original_object":"UniProtKB:P49356"}
{"id":"b90c4330-ed49-4805-9aa7-f81a9ebfe706","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3V7GQ1260K","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:8dfa08e3-4b43-4977-8357-51846bb9dd25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9697","original_object":"UniProtKB:P29597"}
{"id":"bbfcc823-9485-45b3-ad3c-486daa5482d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3320547","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:d4e710be-8706-414e-8160-8a05da64e74b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8963","original_object":"UniProtKB:P00519"}
{"id":"b6f52c18-f9ad-460c-a2fb-c830af61834d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2701","sources":[{"id":"urn:uuid:c382041f-8367-47b2-aab1-b49eaec32b1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P35212"}
{"id":"6bffe933-c651-4d37-a91a-2f510027f95b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:0c9fcdac-b841-4ea0-a64f-060dca410afc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P14842"}
{"id":"732409e8-1d4a-4890-a90a-fe5184af5e69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67WJC4Y2QY","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:afec8973-0cee-4198-a606-abfe86556e4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:163","original_object":"UniProtKB:P28223"}
{"id":"4711ecc1-77fc-4cd4-be5d-58d074842387","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2904","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:5c50a050-f68f-406e-9069-32f4a97e0f88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:548","original_object":"UniProtKB:P08588"}
{"id":"72556cd6-559f-4a79-b689-cedb4ac247b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:8cab8d4d-17af-4ac7-9009-7224b8efcee7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:Q13627"}
{"id":"ce036b64-4301-4914-8746-a1da734d32bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64207","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:43b274c1-83b6-4303-b0fe-fd9f53e01428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:175","original_object":"UniProtKB:P41595"}
{"id":"30048909-845c-45de-833a-af2690d6ed6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:c7b375a7-5f64-46f8-88ae-c95cab5747bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:Q63447"}
{"id":"01157055-153e-4c17-9df2-69f979f18096","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W34UO2M4T6","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:7725e340-bc5d-4755-97c9-44f01b6abb3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5661","original_object":"UniProtKB:P36888"}
{"id":"5a6fa0b0-12a5-457a-8ddf-2fdce26ee1bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45257132","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:eadf588c-8721-4ff9-a78c-b55f665073d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8983","original_object":"UniProtKB:Q9H3N8"}
{"id":"6d2b67b3-3a0d-4c32-bca6-96fc92c36532","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11545181","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:1d756c37-91fd-42d6-a994-84149e732fb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2930","original_object":"UniProtKB:Q99500"}
{"id":"40f1de68-3675-42e3-9cf4-75ac84ab865c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2823659","predicate":"biolink:affects","object":"NCBIGene:5336","sources":[{"id":"urn:uuid:83ba90dd-1849-4b31-8323-49eac2690857","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8820","original_object":"UniProtKB:P16885"}
{"id":"29cc91c8-8b8f-4560-8c59-f52dfe106a6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:788","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:a506882c-8533-45d8-a68c-ac307a017d71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:788","original_object":"UniProtKB:P51677"}
{"id":"f7acac13-91a3-408b-ab88-21890e5dd87c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8W5MLJ83KU","predicate":"biolink:affects","object":"NCBIGene:5550","sources":[{"id":"urn:uuid:cde676b6-cc52-4517-ada2-e1c2d2db3e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6565","original_object":"UniProtKB:P48147"}
{"id":"34041957-a954-41f1-9f4e-ae05b9e05298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1025","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:41ffb466-14d6-4199-9cab-5381619d8cb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1025","original_object":"UniProtKB:P21462"}
{"id":"f90dc11f-06f0-417b-b4b5-07a8fec44963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91934096","predicate":"biolink:affects","object":"UniProtKB:P21588","sources":[{"id":"urn:uuid:62119e12-6a12-46d6-a4aa-a690272e3d88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9023","original_object":"UniProtKB:P21588"}
{"id":"56d2c506-2114-464b-87ee-1af87aeb6fd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:174159","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:3e01c466-9b1c-4136-bb44-9d9d831dbbe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7001","original_object":"UniProtKB:Q92831"}
{"id":"6b4e27db-b5f3-451f-b36a-265ecb2e1c0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:322WXU4AU2","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:1f24f407-06b3-4e99-b527-36f6f0ad9fa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:804","original_object":"UniProtKB:P51681"}
{"id":"aab73c74-f7a8-4433-9fa4-243549104613","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21304318","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:2cff81eb-a397-4dc5-a3f4-ff1218f2b824","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12538","original_object":"UniProtKB:Q9NZQ8"}
{"id":"bdfcebf2-3b26-43bb-854f-f49ed57d8133","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111173","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:b754c3e8-5244-43f5-bbba-ae319d0e328d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5258","original_object":"UniProtKB:Q08493"}
{"id":"6f6e8641-31ce-473d-b648-d6b781f28a32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ERE9QW3XH","predicate":"biolink:affects","object":"NCBIGene:91","sources":[{"id":"urn:uuid:4744f731-a105-4518-96d0-2fc6be46adf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10662","original_object":"UniProtKB:P36896"}
{"id":"08d561b2-94eb-4a8c-9689-970ad251c319","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75142","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:13cb1939-a774-4567-8f3c-3a9f337a18a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8616","original_object":"UniProtKB:P28074"}
{"id":"e516d79c-d994-418e-a011-4e28fbafe372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194079","predicate":"biolink:affects","object":"UniProtKB:E2JF22","sources":[{"id":"urn:uuid:5f6a3772-d004-4694-801d-7cc70778289d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9817","original_object":"UniProtKB:E2JF22"}
{"id":"c40666cf-d308-4f80-b455-5370e060b4af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:174690","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:7e55016d-909a-4642-870e-59725a67342e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12582","original_object":"UniProtKB:P07550"}
{"id":"114879c8-e30e-47f2-a646-af6b71b587c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24825677","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:ca4bf1ad-3afd-43c3-9bff-0d71fb7a023e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11854","original_object":"UniProtKB:Q12791"}
{"id":"57c396ec-1af9-4892-85a8-922a77f6e25c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:8c4d323d-a845-4f1a-8759-ff27ffd8a4eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P61169"}
{"id":"5082354f-4c3a-44bb-b8c4-86683829803e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871653","predicate":"biolink:affects","object":"NCBIGene:4215","sources":[{"id":"urn:uuid:a6906c88-55f9-4757-9526-0f2959b4770b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8208","original_object":"UniProtKB:Q99759"}
{"id":"6c03e8fc-4441-4b63-b72c-0bc1907ad606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155103226","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:efe779bd-d22a-4717-bc3a-8ea1ab393b37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13005","original_object":"UniProtKB:P18031"}
{"id":"e2bcb3b2-6d6b-4c6a-80a2-b9c486d05edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17134","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:5adce518-85dd-443e-bd59-61c15de6199f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2149","original_object":"UniProtKB:Q923Y9"}
{"id":"c97ae851-f626-4489-8190-bb8258e75179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167661","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:fe8177e8-184d-456c-8b07-24f2c2e849dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7958","original_object":"UniProtKB:P49841"}
{"id":"64ec89f3-48e5-4ef2-a2c2-e4cb8defcd49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71727668","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:70bcfceb-aa01-455d-ba4b-a63d14de6beb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9803","original_object":"UniProtKB:P52333"}
{"id":"4037e653-811e-4922-b9ad-cd18acc09c6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1526","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:9af59a25-8d71-40c3-9dc5-c56134476b03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1526","original_object":"UniProtKB:Q63447"}
{"id":"7fec0335-7626-4044-88d0-1320fdd0d3bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PF9462I9HX","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:d4761bb7-6307-411e-a87b-c46d157ec88c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8909","original_object":"UniProtKB:P04629"}
{"id":"4a6f4389-9c28-48d0-9b07-0fbf22464a48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2087","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:e1125ef6-2b67-4a89-b2ee-bc76ecee5850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2087","original_object":"UniProtKB:P29371"}
{"id":"1d4d736c-6a58-45ad-88ba-a1f2c0f7a00e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W0UTB622GK","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:2350ad48-a5ab-45a7-aa93-87b952c3a7fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9287","original_object":"UniProtKB:P35372"}
{"id":"1a981e36-11fe-4e7c-81f0-4b8773af215c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135967","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:6054fbc8-adcb-47ec-91c8-345da550a3a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5758","original_object":"UniProtKB:P25103"}
{"id":"91f0b769-825f-439e-a8f0-b47a1edf67b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1800","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:18d2cd8e-5a28-4406-bc0a-626dfbb9b819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1800","original_object":"UniProtKB:Q03431"}
{"id":"1ca88bb0-8811-49f6-b728-88b4d2380d89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177536","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:53702a14-4280-4bf7-8848-7179f447e4f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8638","original_object":"UniProtKB:P10275"}
{"id":"a721c69c-462f-47ed-98d7-79cf9c6c0d5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817425","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:af6c51fb-d94c-4d38-b47e-c5160bb178ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1552","original_object":"UniProtKB:Q63447"}
{"id":"10941af7-b073-49d3-9185-d6406577cb33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10356116","predicate":"biolink:affects","object":"NCBIGene:1187","sources":[{"id":"urn:uuid:b33fc991-840c-4b5e-b184-cffee00a557c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4104","original_object":"UniProtKB:P51800"}
{"id":"f55de576-9adc-4cbe-850c-d64231fd9e7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6717","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:fc7583a1-1d7a-46c5-8e70-a6e5545e8a41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2593","original_object":"UniProtKB:Q9HCF6"}
{"id":"36d85f9f-51fa-43a4-817e-41f3afce946d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1545","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:bb285cf7-df4e-45cc-bfcc-ec47acebd902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1545","original_object":"UniProtKB:P25929"}
{"id":"e6cb6bd9-e28e-470f-9a48-ffccd694ff75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358788","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:28afcf28-cfb6-457b-b494-36a17c52a544","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12028","original_object":"UniProtKB:P10828"}
{"id":"fa1de870-4c8b-42e1-95cc-178caf391030","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5576","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:64d932a9-ab3a-4924-963e-6db90c02297d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5576","original_object":"UniProtKB:Q03431"}
{"id":"ba40cc07-d6ad-497a-aba5-00ca5bad552d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89455219","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:2a7c7629-82e7-4cfa-93b0-82c14cd4f409","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9265","original_object":"UniProtKB:Q06187"}
{"id":"64ad7ef0-7348-4372-880a-f6713d57b7ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R30772KCU0","predicate":"biolink:affects","object":"NCBIGene:952","sources":[{"id":"urn:uuid:47074d8d-e33e-4c11-bf0a-0737ba77f812","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8719","original_object":"UniProtKB:P28907"}
{"id":"f342e29a-148c-4da4-a59d-f6df225d73bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6360","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:65cea397-6d10-4859-ab4c-122ab8454761","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12499","original_object":"UniProtKB:P59540"}
{"id":"0348013d-1779-4889-9c34-621b3df55441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131409","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:cd1a3a54-7e47-4264-9a8e-94b5665c8e1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6086","original_object":"UniProtKB:Q62805"}
{"id":"6ca32c82-e214-4c1d-8ad2-2fffda8c2ccc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13928","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:b06780bb-59b2-4470-a0d9-b6bcda9c2fbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13928","original_object":"UniProtKB:P07711"}
{"id":"50a76884-4d04-4b0a-a532-347c8e85b188","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:660M185X4D","predicate":"biolink:affects","object":"NCBIGene:2645","sources":[{"id":"urn:uuid:3b939c0d-902b-4e83-b608-26a793ab156a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7701","original_object":"UniProtKB:P35557"}
{"id":"6a9cdb7a-e857-4236-8ba7-8ba3f1becb83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91409","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:cd0ca441-6628-47c9-90ce-7ad7b5608ce5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7953","original_object":"UniProtKB:Q06418"}
{"id":"f47a1772-a605-471c-8cb5-254a700b68f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1825","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:57b3527b-3145-4bce-8202-ed198f5af429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1825","original_object":"UniProtKB:P49190"}
{"id":"59175f5e-0e55-44f8-abfa-cea131478c7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:9afee028-8b80-4e63-adb0-f05ce160ba97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:P35916"}
{"id":"04a965c3-6a11-406a-b71d-105f68f31f0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5441","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:89b67e6e-b974-4c8d-9288-470ca7fdab34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2414","original_object":"UniProtKB:P13569"}
{"id":"a884c57b-d5f6-40c7-97b5-bb4e024e4863","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2275","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:3ed697d2-8d25-4300-a461-990de2953b15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2275","original_object":"UniProtKB:P41587"}
{"id":"697d65f0-4880-47f0-b162-e2484836db94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:d49f5a1e-274c-45af-8311-db7857d7202e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q92769"}
{"id":"f17fbdd6-20c6-4db2-8d37-4d2925fbd90b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311190","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:43c46399-3b1d-4baf-9340-29b6b6124cb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:957","original_object":"UniProtKB:P14416"}
{"id":"953a3acc-e9a5-4570-955b-3c9c54c85394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2703","sources":[{"id":"urn:uuid:82f8e9e8-b942-4e76-95b0-fd005027eb0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P48165"}
{"id":"3bceb6f9-067d-4902-b0a5-972708343271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167657","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:9563a066-35bd-4f79-8df0-d831617e1a7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8016","original_object":"UniProtKB:P49840"}
{"id":"0e95ce9e-6422-4396-bde8-e7253d5e52bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2037","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:08aeff4f-53d9-49d3-95dc-400eeebb6b63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2037","original_object":"UniProtKB:P30935"}
{"id":"a317be0d-7ad3-4d93-8a71-ef6464207f1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197431","predicate":"biolink:affects","object":"NCBIGene:2901","sources":[{"id":"urn:uuid:a436250d-e012-4c5a-8316-7aaea00d919b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4185","original_object":"UniProtKB:Q16478"}
{"id":"ec113cc3-2cf9-4449-a1e7-48d549387fb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10453818","predicate":"biolink:affects","object":"NCBIGene:3991","sources":[{"id":"urn:uuid:31f414b0-c396-456b-8f6e-e9c5b6237c05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6702","original_object":"UniProtKB:Q05469"}
{"id":"1207ed73-2311-4819-bb84-0a38eb452698","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:1ce749e0-73c1-413f-a576-e0c280afc826","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q9UBN7"}
{"id":"f4e504fc-b20b-4352-b426-37fa3f113a6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871820","predicate":"biolink:affects","object":"NCBIGene:5586","sources":[{"id":"urn:uuid:4d505e41-1b86-4963-9fca-34e398656757","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8184","original_object":"UniProtKB:Q16513"}
{"id":"5b9e6c31-b0c9-4ec2-aaaf-70d306dc7b56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:1caa5415-dfba-4dff-920e-68d49ab46952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P04626"}
{"id":"30daec2a-1912-4072-b91b-2b775856dc7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:0e0e2df4-0784-4089-be80-db2f360e5591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:Q14832"}
{"id":"4a84e067-1183-4a7a-9353-7ae09492bbc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17688","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:5ed3a360-a6a7-41b6-9398-8849544b30ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2585","original_object":"UniProtKB:Q9UGM1"}
{"id":"5b280c3d-ff22-4d4c-9b28-d201c5e123e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118561036","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:01044154-8f50-4abb-82be-1e99cb8dff00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12777","original_object":"UniProtKB:Q99720"}
{"id":"a37beb2c-90b3-4c4a-833f-3bdc8d280af5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145704648","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:d9420ada-55e1-434a-8f5e-e0a95e8d3bbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10562","original_object":"UniProtKB:P09960"}
{"id":"0d16ba82-648e-4534-bdb1-e5a7a64665d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9950","predicate":"biolink:affects","object":"NCBIGene:951","sources":[{"id":"urn:uuid:cbe7e4fc-e19e-461b-b660-2e3f0738ddb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9950","original_object":"UniProtKB:P11049"}
{"id":"2c0c0dc4-3744-462f-ac33-47cedb2f5325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:89c068f2-200a-4034-935c-4fc5a695175c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P36888"}
{"id":"3db11369-40c5-48c9-9ca1-402c4b1b3734","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:3820aa76-2245-447c-9ccb-68843bac8533","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P61169"}
{"id":"567edc6d-a209-4092-a756-29b302e558c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162513664","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:c4ff9fc6-8da1-4ba1-b7c9-a662de78ba06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12901","original_object":"UniProtKB:P0DTD1"}
{"id":"cd8a443b-29b4-4ab4-bd15-dfdf5cad8cd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124037381","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:1724a31c-4cd6-43e0-87a3-9383222c55c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9391","original_object":"UniProtKB:Q06187"}
{"id":"ee0c120d-b47e-4ff6-8c55-9f18de367542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93368","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:6b457f92-1abf-4adf-ba87-73a0a6c2f55b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:173","original_object":"UniProtKB:P46098"}
{"id":"c32c55e2-0fab-4ce4-a1d5-98b32aa1a7b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60782","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:be2d3bca-8ca7-43b1-84cb-a3fb1b203415","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1940","original_object":"UniProtKB:P43088"}
{"id":"f6d689bb-78ce-40b3-9479-32189c59c346","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44572818","predicate":"biolink:affects","object":"NCBIGene:51548","sources":[{"id":"urn:uuid:9f4456ba-6b9c-48d0-b97e-6ddfa0a56fbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8816","original_object":"UniProtKB:Q8N6T7"}
{"id":"5de13a93-4ff6-481d-b7df-87dd6f82b670","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:053QD2I96A","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:6f3592ca-0a4d-426c-9b59-dad2de7ffa58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11421","original_object":"UniProtKB:Q02127"}
{"id":"76c228ce-af0f-4813-a2fa-5ef1faa2c919","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74395294","predicate":"biolink:affects","object":"NCBIGene:5209","sources":[{"id":"urn:uuid:9742a77b-8399-4574-88b6-a2f382a85bc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9562","original_object":"UniProtKB:Q16875"}
{"id":"ab07cd41-3228-42dd-993a-f24aa80d5bbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KCN37L7EIH","predicate":"biolink:affects","object":"NCBIGene:10110","sources":[{"id":"urn:uuid:43f82fff-9260-48b7-afe1-acf2a82a9522","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13222","original_object":"UniProtKB:Q9HBY8"}
{"id":"01e36825-2e8c-408c-8709-9a9c7a359e1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:d1a1ad24-fb2c-484e-837a-7f598798fd18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:532","original_object":"UniProtKB:P25962"}
{"id":"84b5a778-69ab-463a-afb0-b168cfeefc73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623350","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:2a7da0b1-3e63-42a3-9a0e-12f544f94416","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2967","original_object":"UniProtKB:P51639"}
{"id":"f39b874f-6da6-4b02-b4fa-40c258be5f64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:259295","sources":[{"id":"urn:uuid:8181fdbc-b563-4882-897f-d009a501422d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P59543"}
{"id":"6db1c534-a3b7-499f-9918-1370b3b0984c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:2a0e9b66-52d4-4207-a544-7b5f28146cd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P08482"}
{"id":"cedbcf00-4352-4dd7-a9a2-df66b22b96bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4172142","predicate":"biolink:affects","object":"UniProtKB:Q8CIQ6","sources":[{"id":"urn:uuid:8d484e84-1298-4826-93a7-56266977f22e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1350","original_object":"UniProtKB:Q8CIQ6"}
{"id":"1911b525-8848-464a-91c0-d87077670a2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30778","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:e212bd4a-5e02-4032-9a8a-a8f23e8ecd63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5549","original_object":"UniProtKB:P00915"}
{"id":"36653f7a-df11-4171-a00b-e6c3faa5a40d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1342","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:6a013b0b-1256-45ee-91b0-91b990b062df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1342","original_object":"UniProtKB:P33032"}
{"id":"6f9c1136-1202-472c-b859-09cad6b053e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6979053","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:fe038022-4527-4ae0-ad06-e2d10213c31f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:288","original_object":"UniProtKB:P08173"}
{"id":"8dac1b45-c47c-465e-8d13-fdfb24bfb888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:6743fc44-74cd-4761-90da-fc790f55f4c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:P49683"}
{"id":"269515d0-589f-433e-a407-517ff79fb168","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44143209","predicate":"biolink:affects","object":"NCBIGene:9682","sources":[{"id":"urn:uuid:1d170691-7a92-42b3-a1ee-1741fe376e7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9584","original_object":"UniProtKB:O75164"}
{"id":"f3d6063f-3d6a-401b-97d8-7a150a319887","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138624627","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:4efc1331-794d-43ca-82a5-343282296fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12871","original_object":"UniProtKB:P52333"}
{"id":"29243ca1-ecab-43da-85c8-cbad6b53f5d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28411","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:4ba3e8c8-02e6-43b7-836a-d6eb7188e1ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2419","original_object":"UniProtKB:O35433"}
{"id":"77ba09dc-a218-4c18-99e5-1305a1a519ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91362","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:7f4800b4-e301-4732-bff0-4726630e9e95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8358","original_object":"UniProtKB:O14965"}
{"id":"1e7fa46f-aaf5-49a6-8780-891c23272c83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56597775","predicate":"biolink:affects","object":"NCBIGene:100130827","sources":[{"id":"urn:uuid:9e00c603-e69a-495d-9e9a-039f29882cf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8213","original_object":"UniProtKB:P0C264"}
{"id":"f5638f87-2e4c-41ef-b1fa-e7cee362024a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73287","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:7c4192a4-a803-40a9-8c9d-30043d446c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:526","original_object":"UniProtKB:P18089"}
{"id":"a4f36944-6605-47e2-9da2-5f5fbd4c4d9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9982767","predicate":"biolink:affects","object":"NCBIGene:1593","sources":[{"id":"urn:uuid:ae9f2b49-ef78-4da8-8572-ff1cf7757467","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8819","original_object":"UniProtKB:Q02318"}
{"id":"0c1d05ea-d875-44b1-9e98-0c08afe1e542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:7821ae88-120a-4569-803f-4d430cf1fcc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q92952"}
{"id":"c3efdd2d-3495-4376-aa30-69d5a763e118","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9543636","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:16fd5cfb-08ee-481a-b56c-9478ece95ca6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2963","original_object":"UniProtKB:P04035"}
{"id":"597960ab-0a3a-4773-8e04-26b3a64eda07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5314436","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:b40e6f1a-4264-4a52-bf41-f5becb92c443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12085","original_object":"UniProtKB:P53350"}
{"id":"1ce56641-25cd-41a9-97d2-e24c3c576ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:e54019f4-ee3c-456a-8882-b49f5010d614","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:O00329"}
{"id":"db96fe4e-db46-48bb-8312-9b54dd02c71b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16978","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:c3c725de-5bc6-4287-8d44-77cc76b66e6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3354","original_object":"UniProtKB:Q9NS75"}
{"id":"33d2653e-bb09-47a0-8767-1fb857d97a47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817467","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:e6f25e46-c7de-442d-bc96-3453b8a0230f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4013","original_object":"UniProtKB:Q969F8"}
{"id":"81f54fbc-d19f-4385-bf71-0e17d346d94f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZKR09NT58C","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:5ba72e4f-0e25-4223-8329-a2aa22b56e5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2628","original_object":"UniProtKB:P15390"}
{"id":"72934a18-0745-4729-bf5a-f453b98a7c2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11759","predicate":"biolink:affects","object":"NCBIGene:5654","sources":[{"id":"urn:uuid:7cd96bb9-a783-4c3c-9dab-b1ea1e192312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11759","original_object":"UniProtKB:Q92743"}
{"id":"9e0848cb-e139-447a-b8d4-2b694c3fa149","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43362","predicate":"biolink:affects","object":"NCBIGene:4860","sources":[{"id":"urn:uuid:017f7673-a6a5-4bd4-a549-0ee48b9e3e6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8272","original_object":"UniProtKB:P00491"}
{"id":"4e2dea41-add9-48a6-8e85-8b7badcb3105","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699461","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:e0182ffd-ce3f-47bc-91b1-ab8aa8fade27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11217","original_object":"UniProtKB:P0C6U8"}
{"id":"570dfe23-005b-415a-99d8-bc957e713be0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167962","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:748c4e0c-8a39-4017-a296-57ee9802e6ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:362","original_object":"UniProtKB:P08172"}
{"id":"291c1216-0c3d-4ce6-9889-31df36f100a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156442379","predicate":"biolink:affects","object":"NCBIGene:56339","sources":[{"id":"urn:uuid:d79a0745-6a75-4e89-b2eb-6394abb6330d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12894","original_object":"UniProtKB:Q86U44"}
{"id":"dd287267-c02c-4e67-a0d7-225e389bb4bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4UN9AOU6G8","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:3506372d-fe48-46f1-8b00-72e836390cf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11798","original_object":"UniProtKB:Q92633"}
{"id":"bfa1f83d-5fa4-4049-8607-5bdcb2c5ad36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9M363811V","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:ff67b0d4-d65c-477b-b28f-277815e08c16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8104","original_object":"UniProtKB:P11362"}
{"id":"73a256b0-6f8d-42aa-8d5e-e59a7a32bf56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:9921c866-9626-49e9-97d4-c50684f8d695","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:Q62805"}
{"id":"1050405d-df48-44be-8b2e-75994d2d83a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9843206","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:799b7870-4a4d-4ef0-be60-2661b5075d3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5964","original_object":"UniProtKB:P00533"}
{"id":"5afd2061-eec6-4cf2-a2e4-423719dfc0ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9863342","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:7e1089d4-e786-4cc0-a10a-2f079b0a40d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2811","original_object":"UniProtKB:P19793"}
{"id":"90ef003f-fe00-4845-bfbb-46e6c052d57a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:ce8dc800-996a-4e0a-80f9-56eb37fa07ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P31644"}
{"id":"d052ff37-e4be-48f0-b068-57060c8877d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6074","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:a92d6b87-fbc5-4037-a986-bc0f7ef9260d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6074","original_object":"UniProtKB:P47211"}
{"id":"f05604c4-e172-4f3c-b568-28a2d6cb6cd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68584","predicate":"biolink:affects","object":"NCBIGene:3786","sources":[{"id":"urn:uuid:e4ecdd18-aafb-4c25-adec-272efcd8bad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2601","original_object":"UniProtKB:O43525"}
{"id":"b66b142b-24be-43c2-bffe-b2d19900933d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13834","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:f6ee5574-3aa6-4744-97df-7730ca52e519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13834","original_object":"UniProtKB:P43220"}
{"id":"002323c7-a7bd-4e09-aa71-19db7210a55c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135244","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:a3e44d70-abdb-476e-839b-6cc265ab3e95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:571","original_object":"UniProtKB:P13945"}
{"id":"71bf7370-4ea6-49b6-b68d-6958fde09459","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228388","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:8b12d377-3e19-41c4-bc7c-19028a763258","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10028","original_object":"UniProtKB:Q99685"}
{"id":"527f10a0-c78a-4546-99c6-421e537a9a50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679305","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:772a3011-ca17-4b4d-ab38-36161c7aa7f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11906","original_object":"UniProtKB:Q9NSD7"}
{"id":"df6efbf0-1832-4041-a0d8-d221e77f8b0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:775","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:1e25c895-fa9c-432b-aa8b-735d5ae3c4a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:775","original_object":"UniProtKB:P51677"}
{"id":"9f1af5bd-35d9-4d70-a9d7-ab2e402cc8d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:2e25ef6c-7024-4ced-99ca-ab3f26c6fe76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:Q62758"}
{"id":"a1da476a-0004-4f71-92de-98b1b3548c0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233324","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:90791ca9-1707-47f3-9355-903128d46223","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11186","original_object":"UniProtKB:P17252"}
{"id":"3bff2aa7-67fa-40df-a817-e8e72af38d76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49662","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:505fc9fc-dcbb-4528-b2e6-4ce791cea696","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1909","original_object":"UniProtKB:P35354"}
{"id":"28f7c146-806d-4a56-a946-cc230048ae33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94686","predicate":"biolink:affects","object":"NCBIGene:5406","sources":[{"id":"urn:uuid:e9e731f1-6327-4cfc-80ad-51e731a97f76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5277","original_object":"UniProtKB:P16233"}
{"id":"433cd322-15e4-4928-af47-b931d35a7772","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:ce6184ef-8031-4e07-9fa3-fb496c31e827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:P06401"}
{"id":"f9d666fb-c0d6-46fd-8bcd-68906fe6d555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41423","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:08d0c316-ee35-4b80-92a2-e10441c882da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2892","original_object":"UniProtKB:P23219"}
{"id":"5101e89e-bfad-4d69-a518-987bdb089506","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72190183","predicate":"biolink:affects","object":"NCBIGene:8639","sources":[{"id":"urn:uuid:8da1e10a-e35c-4323-854f-a975c78112cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9753","original_object":"UniProtKB:Q16853"}
{"id":"9f86a9d7-9064-453c-aa83-e06891ad7274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:20549618","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:299c99f0-5168-43e6-ae69-432e0e0871d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3486","original_object":"UniProtKB:P47211"}
{"id":"13145bcf-35b9-4a82-b571-5136dd5b3560","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2049","sources":[{"id":"urn:uuid:385e93bd-9bcb-4f5a-9333-fd440c7bbeb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P54753"}
{"id":"507e8674-6d95-4623-9c17-daaabefb7401","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9453","predicate":"biolink:affects","object":"NCBIGene:1573","sources":[{"id":"urn:uuid:bcba0685-13e3-45cd-987e-ccadd44767c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2608","original_object":"UniProtKB:P51589"}
{"id":"933b70b6-3fc7-457f-af05-939cf3ad2e09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191050","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:325e198e-0ab3-4a54-a7d7-2a9f97c79602","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:748","original_object":"UniProtKB:P34972"}
{"id":"afd76a6f-06f5-4277-9eeb-ea8c019014f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:70bf07d7-3520-4316-974e-da8ac3638b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9WTR1"}
{"id":"f26cb532-e314-4234-bff3-5a31c15a72c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109549","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:318e26b3-5b11-40fe-af88-1f31047c44d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1356","original_object":"UniProtKB:P49286"}
{"id":"5082082c-baae-4d7c-a906-1426b9cfdcd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70692936","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:b60082c2-cec7-49ab-a985-71231605ccf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3483","original_object":"UniProtKB:P47901"}
{"id":"d30736ff-baec-400e-bbd7-513f945b8878","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81529","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:bf7880b9-2188-4ebb-b3a0-0f970d79f55a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1642","original_object":"UniProtKB:P41145"}
{"id":"d8007eff-c148-41d7-9d15-bc1436f99332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:93586c9b-d1f4-44dd-b540-a2259c67c070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P00519"}
{"id":"1b6b02a8-8b9f-47e7-a436-452d4bf1913d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:3d4585e2-7659-4135-b749-61aadeab4cd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P34969"}
{"id":"7eb8014a-554d-4451-b552-3b5e4a58c023","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118866105","predicate":"biolink:affects","object":"NCBIGene:29392","sources":[{"id":"urn:uuid:2b2061e6-c9ab-476b-aa54-3201e88b44cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10520","original_object":"UniProtKB:P56819"}
{"id":"66b3b92c-b391-47f0-8ffd-1f7da4d2fec5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817418","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:6f27a0a1-4c27-4e73-b11f-03835abf60a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1510","original_object":"UniProtKB:P21555"}
{"id":"3b602cc0-fc9c-4971-a18d-d885f9d40f21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8GU4PSP29","predicate":"biolink:affects","object":"NCBIGene:5153","sources":[{"id":"urn:uuid:4f05bb60-1286-4573-ae19-5bc838721c6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5270","original_object":"UniProtKB:Q01064"}
{"id":"6e40db86-c3f2-4e26-9a91-ef981b621a92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25058139","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:a8eea5bb-5be9-48a3-b0ac-59fddd245666","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9653","original_object":"UniProtKB:P04150"}
{"id":"68855c61-e3a2-44a6-a2ef-020be4853448","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:23387","sources":[{"id":"urn:uuid:ba9ae916-3ab5-46fe-a5bb-da8fdb7b789f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q9Y2K2"}
{"id":"ecb46d81-dacf-485d-a8f6-26f3d8b40f25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:3d82729d-fd67-48fa-beb8-b2f784d2784f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:294","original_object":"UniProtKB:P10980"}
{"id":"636e83b7-738c-4fea-a06f-4947c81ffafd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:816","sources":[{"id":"urn:uuid:fbd2b57f-1ddf-457b-890b-81751e731958","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q13554"}
{"id":"a2bbf5f7-0964-4932-9b15-a329a81065cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4748198","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:e9c745fb-9e09-4cbb-b808-1a896b21e45f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12573","original_object":"UniProtKB:Q9H228"}
{"id":"9437995f-c31b-46ea-a066-f10d0fc3e3ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:ccf83324-e36e-4c3e-9365-e5c324662917","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P31644"}
{"id":"a0859147-7f4e-45cd-ae44-451dd0018136","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0BSC3P4H5X","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:645121a8-234c-41a2-bc18-eacb3a304a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7699","original_object":"UniProtKB:P42345"}
{"id":"9471a2a4-91e1-4b99-98e3-4349112edaa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2703","sources":[{"id":"urn:uuid:b8bf5e69-a786-454d-8a9c-b92cce246595","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P48165"}
{"id":"ddad415e-ded0-4e14-83db-a182e6bd8bb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25229528","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:de51dafd-b1e2-424a-9257-bc5ccb502be1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8220","original_object":"UniProtKB:Q9UM73"}
{"id":"e40ba841-8955-4ae1-b7d6-2384cbd657e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:28e13e1a-b12e-4558-ba88-b730d7c4482c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P06239"}
{"id":"1dff5185-80b1-49ec-9629-ec6cf6b6be00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146466271","predicate":"biolink:affects","object":"NCBIGene:1606","sources":[{"id":"urn:uuid:4a3a8938-fed4-4d49-afe3-cef4018a5046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13006","original_object":"UniProtKB:P23743"}
{"id":"791b95be-c7f2-4464-a115-9a59b57389d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:6c3f4516-632d-4e5a-bb85-8ea170dc1cdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:O60755"}
{"id":"28d436bd-8402-4938-b9d3-2ab0b254253f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:913","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:0f802c12-5c49-4709-b89d-4d6062f2e88c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:913","original_object":"UniProtKB:P34998"}
{"id":"027369df-e2d6-4262-8cf0-cba75253f796","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821498","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c60c64ea-518a-4dc3-9f53-73437f425068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:167","original_object":"UniProtKB:P28335"}
{"id":"06040388-116d-4a03-a956-9f44127981f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:bf751ee3-e2ce-4222-9f4e-aefef1e965c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P28566"}
{"id":"e795e987-73fc-4713-a13b-e2265bba0e27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68647","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:11389bc0-9f26-478d-bc24-d015099e38c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5891","original_object":"UniProtKB:P35968"}
{"id":"31b4968d-4938-4d99-9494-d845f8545d5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122706786","predicate":"biolink:affects","object":"NCBIGene:2346","sources":[{"id":"urn:uuid:6d61d7e1-a050-4a29-bd73-a40cf5221972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11982","original_object":"UniProtKB:Q04609"}
{"id":"38b9c1f7-89c6-4223-b86e-1b665329e578","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13828","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:d85ca6a1-0376-4b2c-b8f7-6698dc108807","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13828","original_object":"UniProtKB:P00533"}
{"id":"f11d7166-6972-4869-8626-89e7dcf4825a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2086","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:9dd0db45-5f10-4166-867e-6291e3937ffb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:145","original_object":"UniProtKB:P32305"}
{"id":"18e7f96c-c451-4b1b-b402-9f05ebf76cb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2209","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:2d7ec6a2-46de-498d-b614-390aedafc290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2209","original_object":"UniProtKB:P47901"}
{"id":"ead0d0e6-60cd-4351-9c1d-1f402c0ba9dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46901383","predicate":"biolink:affects","object":"NCBIGene:25865","sources":[{"id":"urn:uuid:21bf20dc-2da0-4df8-a159-010d28c41ade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9370","original_object":"UniProtKB:Q9BZL6"}
{"id":"8bee06c7-bc71-45d4-89c5-831d04db0f9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10296414","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:b22a64a3-406c-4831-9f59-5bf61d0518ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:76","original_object":"UniProtKB:P28222"}
{"id":"2085098a-31ce-4cfa-b274-033370d45b0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817489","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:0561f862-0b0e-45b4-8495-89a90dbb3f91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6166","original_object":"UniProtKB:P24053"}
{"id":"4a2056b6-0b29-41ad-bc85-271045e8e48e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:1a8fc7f4-0703-4455-8c3e-b8a06b3b3804","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:P47211"}
{"id":"d3a1fdc6-02b8-4878-bfe0-7095c8bc7a24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5478838","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:471668c3-8b43-492f-acb4-d92d62c94408","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9091","original_object":"UniProtKB:P09960"}
{"id":"4bd780e7-8dfd-4dfb-ad62-d27d24e61088","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F197218T99","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:a0edb67b-8533-41f9-b769-59aa7581fc80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12755","original_object":"UniProtKB:Q8NER1"}
{"id":"4854f3c7-2f24-4d89-8c79-775d6708c62a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94686","predicate":"biolink:affects","object":"NCBIGene:221955","sources":[{"id":"urn:uuid:b9d9174c-d878-470a-9d7b-2e89e5240c69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5277","original_object":"UniProtKB:Q8NCG7"}
{"id":"a0efa1de-82c8-48bc-b77a-e869a8db8de6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755079","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:2b35bb2b-1eb4-4780-af33-833e224238fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4112","original_object":"UniProtKB:P39086"}
{"id":"410f8817-5272-4959-85e0-bc173f077d70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17053","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:291c35ed-b0b0-4aac-b212-8a8cdd847a67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3309","original_object":"UniProtKB:O15399"}
{"id":"19666d5f-237e-41ad-8823-a167d2d9d2a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17659","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:fd8ed0e8-9ab6-4203-a3c9-8ac39097fe7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1749","original_object":"UniProtKB:Q15077"}
{"id":"402af34f-35d3-45df-968c-58e5eda934d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4359","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:266bb60c-e1e1-4497-863a-89f99e5eadf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4359","original_object":"UniProtKB:P51679"}
{"id":"81d541f9-5d56-4a66-993f-5f99c8f31ebc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71200","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:bf065746-41d0-4eb2-95b1-1ac71d596e60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5677","original_object":"UniProtKB:O60674"}
{"id":"40eac1e7-dd9b-4bb7-9608-ccadb3ec13e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311224","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:0d279d6d-b41d-4d1a-8fa2-055b065cb842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1937","original_object":"UniProtKB:P30557"}
{"id":"a07c8d60-0c9d-4fdd-909c-72438613ec6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:f36de9f0-8217-4986-a520-25c3ed3e9ea3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P00519"}
{"id":"04f02184-3f48-43a2-9fa8-82fe5b458634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2563","sources":[{"id":"urn:uuid:6949350c-3364-4cc7-8b79-75640b23267d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:O14764"}
{"id":"2d6b69c6-9623-4b23-b70f-b8c586d214af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92537","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:d11610e3-7e5d-4432-bac9-de8f06cb5466","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:28","original_object":"UniProtKB:P28221"}
{"id":"16ea3b8b-4613-41c3-9c15-0cfe8303506e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122670110","predicate":"biolink:affects","object":"NCBIGene:4056","sources":[{"id":"urn:uuid:29792eb5-c026-4aa1-9ed1-173a2997cb24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10479","original_object":"UniProtKB:Q16873"}
{"id":"66d8086f-9981-41aa-b70f-a1de4e263f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FQK825B5DX","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:b7aa2e75-317e-4990-9248-9a0f84d50e84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8862","original_object":"UniProtKB:P11362"}
{"id":"2791ecfe-7221-4c84-bc6b-a707ee48e7b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311459","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:41fc9463-84f5-4076-89ef-59aefa12ff58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1418","original_object":"UniProtKB:P23385"}
{"id":"f1afa301-1dea-4cab-afb3-1e34f0d86eb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25150014","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:852cb236-3841-4f75-8413-c99537ec89e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3952","original_object":"UniProtKB:O14842"}
{"id":"4aeaee5e-8eff-4213-a9a0-1797861dd726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13646","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:b92a9e50-0cc4-4299-8244-633086f3b716","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13646","original_object":"UniProtKB:O14684"}
{"id":"9ef78989-43b3-48e7-80c7-0f4af332eb50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4028","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:9df2580f-3693-4aea-ad27-d95e58bda749","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4028","original_object":"UniProtKB:Q9WTR1"}
{"id":"1d59993f-963b-4390-9e96-7c51b8cd4001","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:fdc7345d-5766-4100-bdc9-290eef3937db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:P51451"}
{"id":"180387b3-8a20-483d-8ce3-8b409dae4556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z80293URPV","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:a52b74e9-c8bc-4d86-8217-a0d455467ed0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8709","original_object":"UniProtKB:P21453"}
{"id":"76131372-b767-4a86-81fe-f98e5d45f0c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UMD7G2653W","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:f85c7bd2-7181-4670-8f57-04eb526cf5a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3059","original_object":"UniProtKB:Q02769"}
{"id":"dd980ea2-d6bd-4d08-8aa0-53c6600048ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311287","predicate":"biolink:affects","object":"NCBIGene:9152","sources":[{"id":"urn:uuid:6fd194b0-e986-4b72-a312-ef8b41ce9d32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4667","original_object":"UniProtKB:Q9Y345"}
{"id":"d6211ab6-bff4-401e-ae89-6ca28b633934","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1990","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:144340bf-f2a2-4347-8a5c-0a7b239a7a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1990","original_object":"UniProtKB:Q9HBX9"}
{"id":"41852003-f55b-4cd2-80ba-ec943a9eff5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8207","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:bffa8963-66cc-4a06-a733-b9332b9bf640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:305","original_object":"UniProtKB:P08912"}
{"id":"fc57d016-29cc-4a5c-9139-80197d112f7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2615","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:69e09f7e-0d53-4c21-9515-3dc292926791","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2615","original_object":"UniProtKB:P35499"}
{"id":"e2c47ff9-5979-48cd-a87b-539ccfe7f8e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5D8VHL5WH5","predicate":"biolink:affects","object":"NCBIGene:7099","sources":[{"id":"urn:uuid:a7bf5cea-0ab2-42eb-a2ce-9f87ecb0bfad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11150","original_object":"UniProtKB:O00206"}
{"id":"01c6e842-559d-4b69-916e-098ab2a3bc1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11855860","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:e0e37116-82f3-4117-b894-6d5aef4ae410","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5562","original_object":"UniProtKB:Q9Y2T6"}
{"id":"2ac9ab05-2295-40ed-b8e4-d080dc2a2cef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16122554","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:8e0077f5-e456-4872-a165-4f8963bf10ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3188","original_object":"UniProtKB:O95749"}
{"id":"e775a24d-9cc5-46f3-b222-42a7228e6281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64045","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:0de10eeb-2b57-4fbe-be28-9a4a32026c84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:963","original_object":"UniProtKB:P19020"}
{"id":"c10c3a4c-3f66-4d65-bae1-338aef3f70dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:65459349","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:aa67be9c-6ad7-44ff-83ae-03d3fdc42ca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11864","original_object":"UniProtKB:Q9UQD0"}
{"id":"f02c98e7-3c56-462c-bc37-baad1aae5d87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1991","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:235051a7-8412-4ef3-b950-1c3f11733274","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1991","original_object":"UniProtKB:Q9HBX9"}
{"id":"e14b7879-0af5-4192-9aa4-1a64667bab91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4F11B27M90","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:fa45e394-c08c-484e-bd57-afff65bcba9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11378","original_object":"UniProtKB:P24557"}
{"id":"ccd761a4-b047-498e-9cb7-84a033fb89cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733035","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:0f212829-5c92-4316-9410-9ed04a240103","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11314","original_object":"UniProtKB:Q92633"}
{"id":"fc4e0fe5-1b5d-46cb-9d4d-ac0700d79fd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:8b95bd40-9979-48fe-93fb-88cb2325c3d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q15413"}
{"id":"e326c308-56d0-4f8f-942d-c713e32fd7ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:937","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:6ae476d5-a9a8-4c1c-a657-37137000809c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:937","original_object":"UniProtKB:P21918"}
{"id":"a3b1ba5c-6ac6-4259-ab3a-a4e4f750fa71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15951636","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:22012b0a-b25d-4b9d-a5b3-7224978bc683","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9893","original_object":"UniProtKB:Q86TI2"}
{"id":"df724776-f610-4b92-8958-9b6b74c90d56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11497","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:9ed7f158-a870-4464-a092-08ccc361dedf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11497","original_object":"UniProtKB:P20309"}
{"id":"5cc06008-43d4-4c6d-b045-f65c6fb62ce2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0T87WD317S","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:5592cc86-c7bc-4fae-910a-b4b409af6094","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5804","original_object":"UniProtKB:P47900"}
{"id":"27627734-51dd-4aad-a45c-2b7df4869eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:0b14908c-5720-4eb4-9279-ea346ec0bfee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2491","original_object":"UniProtKB:Q17ST2"}
{"id":"77ba3e91-ab2d-48a5-9ad6-fca9e061f881","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VKU5X213Q7","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:9aebcdf2-134b-40ab-9529-ee58b5e520f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7879","original_object":"UniProtKB:P04626"}
{"id":"43131f14-2849-42e9-8afc-dbd9adc15e4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UVU4X1103P","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:2cafb017-3752-4008-bf12-30cd6bc10ba9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2808","original_object":"UniProtKB:P19793"}
{"id":"6f7602dc-0168-4c05-a8b8-aa0065d7f6c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67171","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:89c87859-1f1c-4285-87bb-ea18db586ed5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9885","original_object":"UniProtKB:O75116"}
{"id":"b47a13ba-4c23-4d4c-bdcd-84a53072469c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:2be9caef-58ad-4ebc-9f05-a0116b6aec13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P24046"}
{"id":"151edcb8-88a7-4051-9327-17695544d118","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O1Q96UZ63W","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:65c28a3b-48c5-40d3-85c5-59a445874268","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3281","original_object":"UniProtKB:P29276"}
{"id":"1aab3a12-bbc5-4844-8e8b-099109bb537d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31073","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:e1284cd7-c8c8-4e58-b687-0515fc599401","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4264","original_object":"UniProtKB:P48058"}
{"id":"e1d33262-27a0-48dd-9181-67cc7d1ad281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2219578","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:902278df-91d9-4ddb-bc72-c640bc8164dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7694","original_object":"UniProtKB:P14416"}
{"id":"363fa9a5-a1d5-43ba-b4c4-3c606ba85a41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9421","predicate":"biolink:affects","object":"NCBIGene:923","sources":[{"id":"urn:uuid:c0867ccd-6f53-423f-bd46-e1d58043484d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9421","original_object":"UniProtKB:P30203"}
{"id":"0f829be3-c8c3-4075-89bb-6c2f5c9c4944","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10724142","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:ae26a835-8c43-4f5c-a7aa-c4e17ce684f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1002","original_object":"UniProtKB:P25101"}
{"id":"4b76db60-8c79-4d0a-b285-b17e35fa129a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2033","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:d8d97e54-1c3b-4093-a9e8-0ec0a6f25171","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2033","original_object":"UniProtKB:P30875"}
{"id":"d98678ab-2698-44c0-8101-e3df6637271e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124155515","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:88a4e70d-093f-4e3e-b671-d38a88eacf8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10711","original_object":"UniProtKB:P11229"}
{"id":"ae912a80-6e71-4360-b440-643c3056e4af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035974","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:abb7ed37-61f7-410a-91c7-23e52d506168","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4243","original_object":"UniProtKB:Q13224"}
{"id":"f77b3301-f5db-44d4-b8ae-bf2dd19756f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91409","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:72d6338f-86ab-423d-9fc7-f8c8aab8d6a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7953","original_object":"UniProtKB:Q12866"}
{"id":"dc833d08-1925-4f2e-8903-b2a0d0241a15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:ddf80c10-e29f-473b-95d1-d05d201e3f3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:Q12866"}
{"id":"71f82ed1-71e0-4219-9100-12b81616f50e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7465","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:28ba74a7-a256-48b5-92c8-c07d90464b34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1639","original_object":"UniProtKB:P41145"}
{"id":"d494042c-6c58-4dcd-8da5-0659349c6871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93561","predicate":"biolink:affects","object":"NCBIGene:64127","sources":[{"id":"urn:uuid:bb727d6c-4f2c-47fb-9f1e-c44490ea3e65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8887","original_object":"UniProtKB:Q9HC29"}
{"id":"c86bda8d-8226-40ff-a932-6b164792fa25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134301","predicate":"biolink:affects","object":"NCBIGene:225825","sources":[{"id":"urn:uuid:cbfc54b1-691e-46d5-bb71-375bab395c7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13515","original_object":"UniProtKB:Q8K4F0"}
{"id":"bdbd4837-12bc-4d03-b37d-71ba659ca45c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90195","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:5bf82801-aeda-4b84-9afd-8779b1432264","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8367","original_object":"UniProtKB:O15379"}
{"id":"472421bf-d292-4297-81f3-f6e4459856ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422745","predicate":"biolink:affects","object":"NCBIGene:4140","sources":[{"id":"urn:uuid:74801a8d-3d2a-4624-a903-0599ed5fdeb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12936","original_object":"UniProtKB:P27448"}
{"id":"9b367916-0b20-4707-a358-669683560e0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FB39E94UXK","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:874e1bd8-1deb-49a8-b378-f0ce57a61043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10062","original_object":"UniProtKB:Q99685"}
{"id":"f34ea082-4e69-49a8-9765-46b7cc919d8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:94168F9W1D","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:234a7816-2f10-49d3-a099-39ad65f54c4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2089","original_object":"UniProtKB:P21452"}
{"id":"0f81c07c-e0bc-4267-89ee-941486c153d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5289418","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:a6d04e90-ba3a-4d05-a328-3ce1fdd8f54d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11743","original_object":"UniProtKB:P35968"}
{"id":"5940bf5e-848e-4bd9-b67f-9e50c3f02f1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90695","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:cc8f7944-b4ca-4b26-bb42-1330c72b0074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5273","original_object":"UniProtKB:P45984"}
{"id":"c04ed3ff-6d86-4a51-8c8d-1a6e08a4394d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9UP25GJ6E","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:c9bfd6e9-be24-4858-8ef0-40ce5ffeaedd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1259","original_object":"UniProtKB:P58406"}
{"id":"2ff1efc1-67a9-47e6-a022-288346ac2bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:49U9M41BGY","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:76dd703b-8b52-4e71-ab70-453801966d92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3522","original_object":"UniProtKB:P25103"}
{"id":"89daba78-f881-4daf-a3a2-e61feba394fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10037","predicate":"biolink:affects","object":"NCBIGene:873","sources":[{"id":"urn:uuid:5ace7f79-5569-4e0c-944f-5cb80e87690f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5551","original_object":"UniProtKB:P16152"}
{"id":"d9376df1-497b-4588-b751-7983f18f6bef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KQ33EVH4KU","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:4eb4d5eb-0642-44c2-bb4d-88c658815023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9715","original_object":"UniProtKB:P04150"}
{"id":"691e6a99-cab0-4df3-8c28-39571ad65f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4172142","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:b4f9aee1-7f43-4e65-8cc8-c9f4c118af80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1350","original_object":"UniProtKB:P49286"}
{"id":"efb9ef54-8228-4712-aee5-5ea04234f6f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:9a5c35c7-90fe-412c-b33a-841388f9152f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:Q13546"}
{"id":"2d903fa6-7b7c-4774-835f-0ce5a1c742ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27690","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:3a077208-2511-4933-9e72-0c0573a99a43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6792","original_object":"UniProtKB:P22748"}
{"id":"34351b46-b96f-40d3-9e30-430a07f72a16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:54178e65-f8ad-4be8-94ae-e83cdf4f2bf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9EPK8"}
{"id":"980ff801-3e14-4ee0-ac35-969088048740","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93185","predicate":"biolink:affects","object":"NCBIGene:6529","sources":[{"id":"urn:uuid:14fb59a1-4f0d-440e-ac13-d125b26d9e86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4612","original_object":"UniProtKB:P30531"}
{"id":"401aa0e5-889a-4707-89f8-3b85a34e132a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:eb10fa52-3b1d-4040-804d-c99be941b5f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P06493"}
{"id":"4db16d07-77ff-4351-ae2e-a5250e22dd81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352889","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:c7d22b03-8f7c-4830-aaa0-11471f51f3bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3090","original_object":"UniProtKB:Q02769"}
{"id":"5809c350-17ff-4952-aeae-155e9dfeed7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:811","predicate":"biolink:affects","object":"NCBIGene:51554","sources":[{"id":"urn:uuid:1fc29218-44e5-4806-8532-333510820b2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:811","original_object":"UniProtKB:Q9NPB9"}
{"id":"b8472b79-4172-477f-9e4a-ec587739795d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61400","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:b0375b0b-74f5-4ded-a8c9-bce83adaab7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9176","original_object":"UniProtKB:Q15303"}
{"id":"672e89b2-54c2-4751-bb10-ce4c91333a1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679549","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:38018d2f-3430-4de4-be71-68002785e5ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11943","original_object":"UniProtKB:P30556"}
{"id":"8981a360-3247-4917-a3b9-bf614ece8f35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44373472","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:9346b78a-c4dc-4c82-a6ec-7ab27e2ea2bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3107","original_object":"UniProtKB:Q02769"}
{"id":"d646aad9-8522-4996-8301-e73b181c453f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12978","predicate":"biolink:affects","object":"NCBIGene:4070","sources":[{"id":"urn:uuid:d22b483f-7110-4ec2-b3e7-33ba31acfb3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12978","original_object":"UniProtKB:P09758"}
{"id":"d2991c68-a5b5-47d0-b930-f890acdd6325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D99YVK4L0X","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:8f73526d-d2fa-48a2-afbd-639c0b137da8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7390","original_object":"UniProtKB:P35968"}
{"id":"0a033bfc-3e51-4c67-9a7d-c6f681cb0187","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:8f17a462-9128-42ff-8e96-90f01c018192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:Q96GD4"}
{"id":"c7b0adc9-e23e-49e5-90b6-6970fb431492","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53310474","predicate":"biolink:affects","object":"NCBIGene:22953","sources":[{"id":"urn:uuid:6c9175bf-32eb-423f-a721-be3e9e7b8d96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9545","original_object":"UniProtKB:Q9UBL9"}
{"id":"1a9a26b6-b81c-4455-bb6e-d03124cd32d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9362","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:0004f0d4-dde8-4b55-994d-f8284b260bee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7298","original_object":"UniProtKB:P23219"}
{"id":"26696620-f754-447a-9508-193e92f8a47f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3698","predicate":"biolink:affects","object":"NCBIGene:8549","sources":[{"id":"urn:uuid:da5b90d2-8b3a-440e-8af3-32c9d00f15b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3698","original_object":"UniProtKB:O75473"}
{"id":"07b43c42-80f5-4356-8821-64842ce71b9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92168","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:72914d8c-ea95-4c2d-a367-26071d68c4d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5985","original_object":"UniProtKB:P48730"}
{"id":"82c07eea-538e-4945-aed0-8e6e81b9016d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67WJC4Y2QY","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:fea9ce5d-5e41-4d29-b1bc-cc37814b2223","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:163","original_object":"UniProtKB:P28335"}
{"id":"aea626e1-b26e-414d-9374-11d0ef9bfe28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:54822","sources":[{"id":"urn:uuid:7c8ae232-3a02-469a-a514-7b53d777dc64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4262","original_object":"UniProtKB:Q96QT4"}
{"id":"27cb9c75-e544-4808-a685-62b473d9fe56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:820NH671E6","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:db25cbcb-a54c-4ebe-94f6-f61ce15f8e95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9549","original_object":"UniProtKB:O96017"}
{"id":"e25d5b1c-b2a3-4192-8e3d-7044dacf0c03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1790","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:e0819da3-47eb-466b-be1b-af9c04d7bc84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1790","original_object":"UniProtKB:P49190"}
{"id":"b32b9b39-92ae-41da-849e-a951d6c27d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118676295","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:af4bf00e-bcf9-4aa2-9258-737c3d765fc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13885","original_object":"UniProtKB:P15538"}
{"id":"415741e2-4aa5-48fd-8524-4f8376f1996a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:af16eac3-7b9e-4549-98c0-b98cd0b80f46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P35375"}
{"id":"43ffb337-e4bb-4279-867c-9c3054013365","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92859","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:101caaa1-95af-4fdf-8554-964e37adfc3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4024","original_object":"UniProtKB:Q9Y5N1"}
{"id":"3240db7f-08cd-49b4-88d9-2280fb7935c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754994","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:c705a3c0-3539-4c23-8756-07ca66a8e965","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:465","original_object":"UniProtKB:P0DMS8"}
{"id":"4ca9243e-5751-46bf-85a0-78fe3ff3b535","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233316","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:c538b53b-63be-4117-aa18-ab9007d9df0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10317","original_object":"UniProtKB:O00311"}
{"id":"40816a9f-c46b-4b88-987b-fa4a33a759de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5322194","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:5a4d2f5e-13d1-4fa1-ac0d-811d0b198ee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5827","original_object":"UniProtKB:P21462"}
{"id":"6f664dce-2eaa-44cb-a0fc-5a207c3cc012","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132443","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:3df8c42b-89ec-41dc-88ef-a60e4bcd3321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1189","original_object":"UniProtKB:P30968"}
{"id":"1e849327-635c-4d25-9d3e-26b9c8d914ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:770","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:94e28a71-48e5-44ad-8e2f-7f1485c70d55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:770","original_object":"UniProtKB:P32246"}
{"id":"b784c1c0-b213-468f-ad07-35c00f020978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10327625","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:8c0a5e04-d185-462f-8482-e91fa0619ccc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2122","original_object":"UniProtKB:P21452"}
{"id":"4d79b580-545d-4824-8f81-832aa78ca5cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58679582","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:fa72b5b6-6284-4853-992c-e43a7bf62acc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7821","original_object":"UniProtKB:Q07869"}
{"id":"10c6c2a5-9d53-4a22-a8bd-b02a73300c0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604042","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ee6d62b5-407a-4afd-b7d4-729909740753","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:168","original_object":"UniProtKB:P28223"}
{"id":"cfd93ecf-fb21-4672-b20b-a07233adf84c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92288","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:8c3bf51d-af13-4769-8377-b72c4ffbb431","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:258","original_object":"UniProtKB:P97288"}
{"id":"4f296b0c-62bc-4d90-86a2-6d8f98df8dbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142077","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:639f8ce6-9941-4f8e-a202-81fb83bf6b77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9326","original_object":"UniProtKB:P07550"}
{"id":"d17069b6-5bb9-4da0-9c80-75ca17f2d9ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:848","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:495615da-71c3-48b7-a00d-429b9757576a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:848","original_object":"UniProtKB:P61073"}
{"id":"704aee19-3d1f-4e8f-bc8e-bb43dd9d3852","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48569","predicate":"biolink:affects","object":"NCBIGene:768","sources":[{"id":"urn:uuid:c2469cb4-18e2-49e8-b279-3607d8c20928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13648","original_object":"UniProtKB:Q16790"}
{"id":"4f6d189c-0985-46b7-bb33-1586b7f71811","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D23232NSUY","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:273a024e-ead2-4d82-9d55-06b81d1ff187","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9634","original_object":"UniProtKB:Q9BXA5"}
{"id":"9aaf5f6a-454b-471f-99b9-97dbcf93c4b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593561","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:8d312f50-774b-45d4-98fb-c9f0124fe6fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10530","original_object":"UniProtKB:Q00534"}
{"id":"4c70b41c-d823-4ab7-89f7-91f501f2744b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:490561","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:311279ba-4288-4962-bf85-917313c9cd02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:336","original_object":"UniProtKB:P04629"}
{"id":"01eb859e-7553-4215-95fa-45997d640a3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:44SP3I6R9G","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:1c0787b1-d168-4eef-a35f-6f56630891ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8502","original_object":"UniProtKB:P32247"}
{"id":"b99f72f1-e088-48ae-aa8c-f9e833125586","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0I579CNG0I","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:c1fb5171-977f-4553-b864-3bc1486da20f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2308","original_object":"UniProtKB:Q12809"}
{"id":"d61da205-3031-4da5-b191-5b62b3a94a31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63452","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:6cf5dcbe-10d8-4e05-94b5-e9e5fafe2dcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5702","original_object":"UniProtKB:Q9NRM7"}
{"id":"bdb527e1-ed0c-426b-b757-872d49cdc89b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600924","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:6ccab2bb-e7d0-4d87-b85b-02181deb1fe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10540","original_object":"UniProtKB:Q9Y2T6"}
{"id":"942dbef2-9a36-43ad-9106-6f7578815b94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94343","predicate":"biolink:affects","object":"NCBIGene:60482","sources":[{"id":"urn:uuid:ad26a074-a44a-47ad-bb20-72625aafe428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4494","original_object":"UniProtKB:Q9GZV3"}
{"id":"131c3e03-ec71-4c4b-8d3c-08cd23f76622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133017","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:6f5d6291-d4d1-40e5-bfd1-1166013c0321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8423","original_object":"UniProtKB:P28223"}
{"id":"abdbf81d-cb28-4ae7-bf89-a2c1c1bd4144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:193122","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:8ce0f7b5-5466-4d71-8754-c0aaa938ac8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:542","original_object":"UniProtKB:P08588"}
{"id":"6cd24a2c-2e50-48ed-a134-df2c310713b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70812729","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:e9da3df2-699f-4758-a88f-1ba6012b7982","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12570","original_object":"UniProtKB:Q9Y5N1"}
{"id":"b5cd2167-5aa5-4f94-aa6a-86c8ceaccfe2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6TLR8U8O3C","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:ec971031-9316-470f-96b0-30ec22dec701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9919","original_object":"UniProtKB:P00533"}
{"id":"44baeaad-9ce2-465d-b7c9-24299ce0150c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71584823","predicate":"biolink:affects","object":"NCBIGene:9152","sources":[{"id":"urn:uuid:4fc6976e-522d-49f4-8f1c-c89b520e2a20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11297","original_object":"UniProtKB:Q9Y345"}
{"id":"29bda04d-0e7b-4a94-82dd-af3abe737210","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168510218","predicate":"biolink:affects","object":"NCBIGene:83873","sources":[{"id":"urn:uuid:28e5ff42-67bb-4983-a3d7-4fe00d56ed72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12948","original_object":"UniProtKB:Q9BZJ8"}
{"id":"4181db05-4c2a-4190-b52e-f7cc838cf6e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:f9427b8c-5d66-493a-b30a-7318ef819e3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:Q9BY41"}
{"id":"10be943c-5dc6-4986-b968-f120dec47352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95087","predicate":"biolink:affects","object":"NCBIGene:8242","sources":[{"id":"urn:uuid:b524fcf9-e494-4345-8490-a894a81f8e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8229","original_object":"UniProtKB:P41229"}
{"id":"d1c21b80-7438-4a73-b6b7-420e69241967","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162422438","predicate":"biolink:affects","object":"NCBIGene:29028","sources":[{"id":"urn:uuid:4b9c5211-763d-42fa-81f4-29ba865b82be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11939","original_object":"UniProtKB:Q6PL18"}
{"id":"eefbf88f-ace0-41d4-b1f4-203eeabf64b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:baf77853-b595-404d-a55a-ee71954b33fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P04626"}
{"id":"6c3d0579-02ae-48ca-bbfa-ffc750361a53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311225","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:af418226-c3d7-451a-bbdf-2bd388ff4ec3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1918","original_object":"UniProtKB:P70597"}
{"id":"f12dac4b-3b36-4ff2-b89a-0eec8fccb002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1777233","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:11defee3-b554-418e-95f8-b7d7c24f1f42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8729","original_object":"UniProtKB:P49798"}
{"id":"16da7300-7caf-44d0-8a94-59e247aea8cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RR6P8L282I","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:dd99762a-0bb6-4b24-bd29-754e379773f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9289","original_object":"UniProtKB:P21453"}
{"id":"c51d03d3-0261-421b-9763-33f15cea017e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118273623","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:dcb053d6-127b-44dd-93a7-fba791f404ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12002","original_object":"UniProtKB:Q15858"}
{"id":"93f147b1-8c53-46ac-b765-ec6d2102ff89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81391","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:0c790ad5-14d5-4a6d-9496-d8adbb5e6879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1267","original_object":"UniProtKB:Q91ZY1"}
{"id":"f56ea744-a478-409f-b8d6-5fa07ec870af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2080","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:23f3edd0-6cda-4817-9a4d-545b6a3f59fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2080","original_object":"UniProtKB:P31391"}
{"id":"cf313b3a-83e6-4907-a48e-a51eb596f542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177647","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:2273f8bd-3c80-42ea-93d1-e9435a545107","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5604","original_object":"UniProtKB:P30542"}
{"id":"0e602051-525c-4690-afd6-4faa8863447d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643961","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:b5740cd8-b290-43e2-9899-36716ef22214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2794","original_object":"UniProtKB:Q9GZU1"}
{"id":"15f23f10-7ffa-46da-84e1-b067189a8747","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:6e0b816a-ab85-4d71-aed1-ebc4a27c3eab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P97794"}
{"id":"1005e420-3b84-4eeb-a955-702ee44072b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45257132","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:65164451-ce77-4ba2-a20e-cd8e9ddd3650","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8983","original_object":"UniProtKB:Q9Y5N1"}
{"id":"19f40d83-7cc3-4d35-b376-1d007eceb195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699442","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:fede1085-1921-4a9b-a6de-0a55aa832c8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11099","original_object":"UniProtKB:O76074"}
{"id":"4764595c-7afc-4c25-9fef-f660be5fa380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:3ec8d847-b9a3-48e3-b8fb-0fc2108d386e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P08908"}
{"id":"faf003b2-528d-4eb9-b213-0966b920630c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104162","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:c598688a-30d2-4696-ad11-d2116fa31db9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10104","original_object":"UniProtKB:P35367"}
{"id":"c6ff2807-40b5-489d-aa4d-b84406da1d60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93519","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:56421812-a126-4692-adbf-d986aa1561a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:187","original_object":"UniProtKB:P28223"}
{"id":"3e9f2529-5cec-4930-a2e1-579a7c6d7395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164234","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:67c3df34-fd67-444b-b7d8-df7cba7b4d3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:643","original_object":"UniProtKB:P97583"}
{"id":"2c31d1c0-e3ee-4de2-abf4-083409c56a15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42519285","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:0cb2b0da-a67f-430c-8880-63909d35ebd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8591","original_object":"UniProtKB:P08173"}
{"id":"68fdcb8f-acb9-4f06-8ef9-2369cd0c7bbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48723","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:db12041b-e7ec-44e2-8cea-a7456e8c3554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13498","original_object":"UniProtKB:P43681"}
{"id":"99319193-bd09-4f41-8b46-7d16f05883fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49490","predicate":"biolink:affects","object":"NCBIGene:5164","sources":[{"id":"urn:uuid:a4c6c7a8-cc60-4881-b2bc-e13659e2bc43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9362","original_object":"UniProtKB:Q15119"}
{"id":"effe0f19-5712-4a55-8a66-6f6df8794029","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4L1AM42NVA","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:bc5f6c87-ac86-43b7-b5ab-dfc6172a4d82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7971","original_object":"UniProtKB:P23458"}
{"id":"a46b4ea9-482c-480a-8bd0-08379a1a73a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16827","predicate":"biolink:affects","object":"NCBIGene:14815","sources":[{"id":"urn:uuid:f131c2fb-05f0-407c-b75f-aa798545dabe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2869","original_object":"UniProtKB:P06537"}
{"id":"7e74c6bb-ee0f-4eea-a160-3a13f975847f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53115","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:a2755929-37fc-4d54-be61-adfbb2679f44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5609","original_object":"UniProtKB:P30543"}
{"id":"34da40ca-1b14-493d-b9d4-b78a9f73a5e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22146595","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:35d94e02-610c-49fd-bec8-170351ccac6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:618","original_object":"UniProtKB:P24053"}
{"id":"c2975eb7-3f46-42e0-986d-1251de832181","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10981286","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:e299e27d-8666-4be5-80dd-167afa7cc148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5599","original_object":"UniProtKB:P30542"}
{"id":"1be0c381-eaab-42b1-bdf3-0340b52c6499","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232985","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:7adf2b80-6a82-4571-b66c-5bc9026330dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2318","original_object":"UniProtKB:Q92952"}
{"id":"bf704f0a-aa09-4f1d-858d-ef5c0324d662","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438353","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:715f8d3b-51f5-4106-ab6f-c4e0055917bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1634","original_object":"UniProtKB:P32300"}
{"id":"59b780e5-92c8-4cc9-8c12-e9d4e30043c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167686","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:aa2c651a-9af1-4245-bc94-9f8833d1b9b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5671","original_object":"UniProtKB:P17948"}
{"id":"ee48ad60-50a3-466a-9dbf-b5fcc07cf2d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72163809","predicate":"biolink:affects","object":"NCBIGene:1457","sources":[{"id":"urn:uuid:803742d9-01bf-4cb2-84d0-cdb3f66e8b01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8128","original_object":"UniProtKB:P68400"}
{"id":"966aa0b1-d2b2-445e-96dd-5dc42de9aa42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:848eb5c4-cd5f-4401-bdb0-dbe02b6c1477","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P34969"}
{"id":"529c4c0a-f9a2-4ee9-aa4a-368f8418917d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643961","predicate":"biolink:affects","object":"NCBIGene:255231","sources":[{"id":"urn:uuid:0553992d-da13-49c4-bc87-277516326062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2794","original_object":"UniProtKB:Q8IZK6"}
{"id":"96a60288-7817-4540-a366-8bfcdd73278d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6970","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:de694ea7-c517-4821-854d-2af892426dfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9029","original_object":"UniProtKB:P04150"}
{"id":"7535cb1a-38d3-4e5f-9e1d-6d00eccf5d7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79042","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:5788d458-3f5d-408d-aec0-48586491e28b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7393","original_object":"UniProtKB:P48039"}
{"id":"6dd34dbb-dfb7-401f-97b7-3b45d3d5d55f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2615","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:b7040943-1953-4c2c-a76b-4e02c57623f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2615","original_object":"UniProtKB:Q9NY46"}
{"id":"af8c7e0b-ef26-4236-8fa3-fe77cc6efda3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25141190","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:9faec44b-e3de-4a10-835e-133309803f9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9478","original_object":"UniProtKB:P51679"}
{"id":"e4de8e3c-d694-4a5c-b8d7-6cf7034c3795","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5542","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:8a36fbd6-44e5-4026-bf0d-cbdf0877a39c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5542","original_object":"UniProtKB:O35433"}
{"id":"a8e9759c-51ea-4b92-87fa-310f5fa6529c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4856","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:62c275a0-0933-404e-9c9c-e18e0f5d5e04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7178","original_object":"UniProtKB:P08588"}
{"id":"774a14af-5aad-496a-9e22-fa58fe944081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:e6ec82ea-6d1c-40a4-912c-b9392fc208a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P41595"}
{"id":"6df2f8ed-b094-4d8f-a820-0def49175ff9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45257132","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:24e3e013-4482-426f-b6f3-302a21a40af1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8983","original_object":"UniProtKB:P35367"}
{"id":"7a57cede-3868-4dff-9f9d-863ea0e76f7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93701","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:c2f1c47f-70e5-4da4-8dc2-62f1afb7c58b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2200","original_object":"UniProtKB:P30518"}
{"id":"7da3b138-0404-4e86-ad9d-c003606e1dc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4170630","predicate":"biolink:affects","object":"NCBIGene:7184","sources":[{"id":"urn:uuid:f569cdec-77b0-44ea-8aa7-e25522c94cba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10118","original_object":"UniProtKB:P14625"}
{"id":"280af2c3-d4ee-43d7-a835-6c8af17fb802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155289332","predicate":"biolink:affects","object":"NCBIGene:641","sources":[{"id":"urn:uuid:899588dc-afe2-4f58-a994-6d91a90f1e48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13027","original_object":"UniProtKB:P54132"}
{"id":"f3c9c75c-5493-4006-8e9b-e221834726ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11675054","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:d11eb9ec-86c6-4700-ae90-a396e1400b65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8160","original_object":"UniProtKB:P11802"}
{"id":"3d1e4e4b-f99d-431d-9685-d4be0962d505","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:143239739","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:26b6d363-f14e-48ff-8b36-1e3f9e1f140f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13927","original_object":"UniProtKB:P07711"}
{"id":"1cd89b43-3a66-4089-9357-7d1f18475d7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23648296","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:bebfe2b0-3698-4e5d-98bf-81d140dd37c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9298","original_object":"UniProtKB:P07711"}
{"id":"bb808ccf-f2d5-4521-a1bb-a1c6c2d3268e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:41fa36dd-cab9-472a-b1c8-6e6b4bf2b801","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4262","original_object":"UniProtKB:Q9UHC3"}
{"id":"457b1134-6621-4693-93be-4daf260f6326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10127","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:b579761c-217a-4435-bb93-208b8b30d7d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7047","original_object":"UniProtKB:P00915"}
{"id":"43a7ea5e-5ad6-4444-a076-62c59e3a8336","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:1183","sources":[{"id":"urn:uuid:b3bf2e6c-578a-446d-9161-8934e9468b88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:P51793"}
{"id":"5db90d3a-41d9-480b-ab21-4325fcccdf28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:13389","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:ec743b58-68ec-499a-974f-cfa8da063725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2451","original_object":"UniProtKB:Q96G91"}
{"id":"f509eddf-2f45-41cb-93bf-e272d2a46955","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81527","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:11f9f34e-c8ea-45ef-ad4c-5dee8bf40228","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1631","original_object":"UniProtKB:P41145"}
{"id":"70a6192e-162f-4691-90a9-c4d83c2c0c91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3112","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:d4581e22-3089-4741-b669-d42a9708f1ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7128","original_object":"UniProtKB:P08172"}
{"id":"affab2b0-9b8b-41db-8ece-c1ad4fade99c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34662","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:9ff21f9f-d6f5-4279-9cce-2fffa7a14e34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2324","original_object":"UniProtKB:Q9UGI6"}
{"id":"efcfdd3d-9cb7-4a99-a88a-d33dc99e0f7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JQH481R778","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:12fd7e9e-b5b7-476e-a206-896d28ad1218","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7371","original_object":"UniProtKB:P36544"}
{"id":"7609701e-8f10-40a7-9e66-47246ed182e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5810","predicate":"biolink:affects","object":"UniProtKB:P0C0L6","sources":[{"id":"urn:uuid:3bd0211d-b665-4b3e-ba7d-91e5a84d8963","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5810","original_object":"UniProtKB:P0C0L6"}
{"id":"58119277-f5a5-478c-912e-7c2aa11cbc67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233412","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:69ac9b8b-389c-4b06-8926-b454bfe35c0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9320","original_object":"UniProtKB:Q9H228"}
{"id":"b47c56f8-18f8-4bd4-94b1-d79e795ad9d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:653","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:97fd8acc-6ecf-46b1-a5c0-c25070001de7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:653","original_object":"UniProtKB:P30411"}
{"id":"aa0516bf-c686-46d0-9905-0bac2dc2e1e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:170123","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:b2ad8762-9162-43ab-9635-da51e018b3ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2936","original_object":"UniProtKB:Q9HBW0"}
{"id":"055c021f-2b2e-4222-a0a8-e170dd55ba77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79560","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:13aca9d1-ec2f-4d20-b672-6148bb3330cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4210","original_object":"UniProtKB:P48058"}
{"id":"7d73ccaa-6d45-4967-90ef-dc9709c01405","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RR6P8L282I","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:b2955291-9377-4b1c-9510-d925bb1e9e09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9289","original_object":"UniProtKB:Q9H228"}
{"id":"66e57062-5c75-400b-919a-1d2e5e1afaf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:a4f7f2ab-1a86-452b-b0ee-61feb14fcf64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:P49841"}
{"id":"98ba917f-1439-4cc0-a5b1-4d0ec1964e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Y869C2THE","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:fa5ddb82-4224-4ecf-826c-e739da7fc3b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9850","original_object":"UniProtKB:P35354"}
{"id":"d7e4ef73-944f-4e6f-90d0-6cf27200c7b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:661524","predicate":"biolink:affects","object":"NCBIGene:213760","sources":[{"id":"urn:uuid:2b86653d-c446-479f-8c49-200e01c469a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8491","original_object":"UniProtKB:Q8C167"}
{"id":"6b555a78-8bb7-437b-8dd3-63b927b35b94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:8837792c-336f-46db-b6c6-ac87be3e7c63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P43088"}
{"id":"f48ba645-3980-4398-b763-ccfb3a861748","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3P63ZTE3OY","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:2dec4c55-b993-4188-94e4-4d996bed7ef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10618","original_object":"UniProtKB:P09619"}
{"id":"0e002a0d-0c85-4dc3-ab13-eaff90b7c2cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6942","predicate":"biolink:affects","object":"NCBIGene:3764","sources":[{"id":"urn:uuid:aeb32b75-3757-4038-9730-9847dc94c6b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4254","original_object":"UniProtKB:Q15842"}
{"id":"3e061b2d-a9d1-4fd5-9a6a-cec7d5ab87cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311023","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:44fdb7a1-2672-4d9b-a336-d83b1df4118b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1485","original_object":"UniProtKB:Q9GZQ6"}
{"id":"81c938ef-56a7-4125-aabb-2d84dd290485","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71817810","predicate":"biolink:affects","object":"NCBIGene:64167","sources":[{"id":"urn:uuid:c28c9e46-df94-4ea1-9a5b-e5cf769c04df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8666","original_object":"UniProtKB:Q6P179"}
{"id":"c42bc303-52c4-4bb7-9e2f-c966810f4338","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"UniProtKB:P30940","sources":[{"id":"urn:uuid:c1afba51-2b1c-4dc6-a2e8-ad07307c1835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P30940"}
{"id":"72ccc74d-8cd3-44c9-80e5-136b97732069","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:23XF3D2L3N","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:ad874979-4336-415f-9573-0086eee8940b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1401","original_object":"UniProtKB:Q14416"}
{"id":"41e7e2d2-83c9-4d99-b7d6-25059c9d6b8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53391766","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:866c9fb1-0a03-4ea8-90ed-ed19a20eef7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6217","original_object":"UniProtKB:Q14831"}
{"id":"4c8e8220-d5c1-4298-81ac-0c1df3429040","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:617","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:75bd49f6-50ac-4fc4-bc94-d999c6caea7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:617","original_object":"UniProtKB:P30550"}
{"id":"dcd3ae20-1bbb-4625-bbf0-8fdf3c8b3383","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023738","predicate":"biolink:affects","object":"NCBIGene:6196","sources":[{"id":"urn:uuid:693bf877-ac1e-484d-81c4-3ebda142b66d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8038","original_object":"UniProtKB:Q15349"}
{"id":"c83ebd56-7ff2-4cac-baf7-60916e18b6a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122119","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:54565cda-6ce2-4526-9ea3-3d6c775950cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:882","original_object":"UniProtKB:P32239"}
{"id":"ca45b939-27ec-4008-9c15-980905acb00c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:92feb7e7-6089-42db-880c-3af59b02b2cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P25099"}
{"id":"dfa8ed59-9473-41d0-8888-9f5c0035525c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135244","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:60898576-4cf9-4e94-b5b2-5cd3ae0f3c37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:571","original_object":"UniProtKB:P26255"}
{"id":"c516f29c-3da3-41b4-89d5-becabc671f89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67CKV7X08G","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4b3b759a-b4c1-4540-899e-b7d9b14b157e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5615","original_object":"UniProtKB:P0DMS8"}
{"id":"d702c51e-1c88-4508-9c51-d5044acf5777","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31085","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:a53dca81-eaae-4688-ac7c-5b2ac3c4ac2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:218","original_object":"UniProtKB:P31388"}
{"id":"5f1df762-05ea-4433-afad-ce498c12bc90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"UniProtKB:Q59H18","sources":[{"id":"urn:uuid:88fb1808-eece-44ca-973c-10680fd0829f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:Q59H18"}
{"id":"cb4f9f07-ee0e-4e41-83a2-8e0d89c4c9f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182183","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:4b547393-23fa-4962-be5b-ac8b7d8241f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5126","original_object":"UniProtKB:P17752"}
{"id":"552e9e1b-c78d-4684-9d06-503228253e3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53344810","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:ea4977eb-ee47-4051-9c07-f9772c37063d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7716","original_object":"UniProtKB:P56726"}
{"id":"19c4c087-cede-482b-933c-daf587eaeef3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2562","sources":[{"id":"urn:uuid:425e2cef-d8c5-4568-ace7-2fd1e067418b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P28472"}
{"id":"ea309e70-a026-4841-a23c-07ff70f521e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75095","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:174b03be-02ac-41df-8c4b-1ec66e3323f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8789","original_object":"UniProtKB:P04798"}
{"id":"bc81be19-515d-4197-a6c9-20de377d58ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59750","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:9c44e71e-3a58-4688-a963-3274cc9edac3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7068","original_object":"UniProtKB:P04150"}
{"id":"5bea189b-d778-4f5f-b55c-555559120259","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:670c72df-85c6-4342-9e46-0aeee0085e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q8TD43"}
{"id":"8dd98c09-32c8-4f7b-af93-95f87c80d145","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4562","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:46f9acae-d964-4f8a-9875-e5d45bff6593","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:121","original_object":"UniProtKB:P34969"}
{"id":"6d794818-7861-439d-a197-6f9d7feb905d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10739","predicate":"biolink:affects","object":"NCBIGene:6446","sources":[{"id":"urn:uuid:8863c41d-f988-4b01-bf11-d9bdaf0ab7fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10739","original_object":"UniProtKB:O00141"}
{"id":"6b0799c3-7387-44db-87a9-98a87a726d77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:13fc6081-80c8-4040-9e9b-8e189baf29a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P34969"}
{"id":"d53a47c0-a7e9-45d0-b6ea-4f6cfd666691","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44331800","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:fe57177a-21e5-44df-9f21-3194dfd3a680","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2976","original_object":"UniProtKB:P51639"}
{"id":"376bbe85-6841-40a7-81aa-3da65ce39bb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135439060","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:ff253b65-871f-4ff6-b26c-77cdd77d2e7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5524","original_object":"UniProtKB:Q13304"}
{"id":"bb72d1b5-84a7-4a94-b124-21cddbbee878","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1987175","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:c25d19e7-e6fb-4219-9eec-39147e526366","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9283","original_object":"UniProtKB:P35408"}
{"id":"5c5c8310-ff75-4fb9-ba75-5683ddd70d76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11305809","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:d8c11d18-0aab-439d-81d0-df4b54db2e08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9988","original_object":"UniProtKB:Q12852"}
{"id":"6c9d8c7a-8de5-481f-aba3-b18c8ab3e67e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R1XBQ6NTFR","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:882bac9f-7634-4fa0-8a5f-fd1f048a40b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:154","original_object":"UniProtKB:P28335"}
{"id":"213e9aa4-d87b-4d9e-87c4-817afa6bd93b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:3131b124-2955-4351-af01-7d029083dc75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P21731"}
{"id":"a6d7ae0b-912c-496e-9973-04a198ddc7d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14840431","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:0cb964a9-f082-4632-84b8-13ec281fbf25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1615","original_object":"UniProtKB:P41143"}
{"id":"eb58efef-5228-461b-94b9-bfbf3d84ae09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2613","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:49aae540-b1f9-403f-93c8-e118b8305bf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2613","original_object":"UniProtKB:P35499"}
{"id":"ef2d5882-9055-4c2d-bc67-be708606d316","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90695","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:33fef1fb-6d9b-4b2a-800f-25c40cb3230d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5273","original_object":"UniProtKB:P53779"}
{"id":"f479a69a-e5ee-4857-8d84-ee90c4cb62c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29009","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:c5099110-e5c2-4eb8-823a-773af568a841","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1242","original_object":"UniProtKB:Q91ZY1"}
{"id":"bce27333-2c63-4b09-8d75-c58240650c36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91437","predicate":"biolink:affects","object":"NCBIGene:9833","sources":[{"id":"urn:uuid:8193af83-d91a-4e6a-ad53-cc06dd50cea4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11457","original_object":"UniProtKB:Q14680"}
{"id":"ec0088ce-3308-41a2-a1e3-0759803e6b2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B2LW71CRGL","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:7bcf3ecc-fac6-4d6c-8238-d01e3a736e00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11951","original_object":"UniProtKB:Q13258"}
{"id":"84b16ebf-d2bd-4add-8d32-d10f0e7ea50c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75404","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:57cb61c4-0c14-4a60-a729-19b2acc14e51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4862","original_object":"UniProtKB:P00533"}
{"id":"0402fb46-9818-4cbe-af71-be4aabb0e786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:1f37cd36-afb8-4631-bf03-ff780bad73db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P25100"}
{"id":"4a5841bf-ed6d-4d64-abe5-5911c066d0e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72163809","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:c8cfe158-dfb0-4f64-8e46-8cafc399c60f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8128","original_object":"UniProtKB:Q86V86"}
{"id":"c33afe0c-9f9d-4d73-8d06-9cd54078422f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25002940","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:90007372-519f-428a-b0bd-1d985fc89002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6320","original_object":"UniProtKB:Q14416"}
{"id":"439f72dd-b3cf-4148-8319-7cb5f3feb319","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:73SM5SF3OR","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:1b2a969e-0078-41bf-b3dc-ebd2feb72a73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9991","original_object":"UniProtKB:P23458"}
{"id":"a7ea910d-18c9-4329-81e7-d3ba2f245b17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:57144","sources":[{"id":"urn:uuid:68c58f62-0d7c-4982-a517-7b8f8623e255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:Q9P286"}
{"id":"b331e988-f439-4dd1-a34a-ab70d3fef281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358785","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:13ba21db-6bf3-44e0-ba3d-d27aa4f7b5bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12001","original_object":"UniProtKB:P00533"}
{"id":"7c190823-046c-49a8-a656-1dc871f7c3c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:ab8519d3-ef3f-472b-9d74-b77edfdc2eea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P32240"}
{"id":"3f059ae1-d70a-4146-8caf-c01c4604ff1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66964","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:be7b07e9-224c-4def-92c2-02f6f882e73c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2424","original_object":"UniProtKB:P23415"}
{"id":"a6fc27dd-bb87-4ff5-bbcc-6f3041dd1bd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:61OTZ32XNC","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:ef58ed73-eb26-40a3-a350-ecabeeb426ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10169","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"0296b227-fa0d-4c41-85c5-2b0e3345f4a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:58cc1e90-0e23-4450-803c-043a8595a1f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:Q15759"}
{"id":"28e8eb3a-133a-41b6-a95a-a77e117abebc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:22e4a8ed-e920-4724-b987-d8a4a8e18580","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9H1D0"}
{"id":"ec35f16d-2dfc-4fb6-a4f4-524b8c0b91c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:9cf8e681-2d02-4913-a944-8b565ebf8a25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P08173"}
{"id":"46ddf353-7446-4916-b98c-a3a2aa6afeca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4648137","predicate":"biolink:affects","object":"NCBIGene:170731","sources":[{"id":"urn:uuid:bd804a60-03d2-478e-bff1-e68707d31d7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11077","original_object":"UniProtKB:Q80U63"}
{"id":"942495aa-7e23-41df-9d82-d6dd37c673e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16196","predicate":"biolink:affects","object":"NCBIGene:5338","sources":[{"id":"urn:uuid:c49d7d2e-399c-489f-9e8e-8130c6782e94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1054","original_object":"UniProtKB:O14939"}
{"id":"28e7d1eb-4942-46cd-81b4-256cc479d76e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136041","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:bc5b5518-6d9e-41f9-9c12-a2f472d9675c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9395","original_object":"UniProtKB:P13866"}
{"id":"cb783914-2b8f-47d9-9bb4-dc87d4f39e33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:12289","sources":[{"id":"urn:uuid:e73f2ff0-fb89-4497-b137-5dbec56348cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:Q99246"}
{"id":"25dfeed5-a4ec-493f-b4cb-abb80abb0a86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9935197","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:81648e53-997a-4976-89d0-ad0455491a73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2688","original_object":"UniProtKB:Q13133"}
{"id":"6f67201d-1aae-4445-8fd6-58bf646d3aa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817461","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:8796bb08-c099-4377-bba3-f7946a9e0c82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3848","original_object":"UniProtKB:P25929"}
{"id":"4d97bd9a-324d-4427-a21b-c23c269cab6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J1I0P6WT7T","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:16afdbb9-094d-4bc5-8e2a-d839e3f0de96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8699","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"5bf123f6-21a3-486f-bca7-f650bba3c704","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54585418","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:9e69fbdd-af54-4098-93b9-36534cfa1355","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:745","original_object":"UniProtKB:P20272"}
{"id":"db4bd3b7-c6b5-4dd5-b904-8d720961e55f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:91ce5fa6-e7ad-47f6-afff-1e171949985a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P28223"}
{"id":"42face1b-b87b-4982-ba4f-abb827bb7ef9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3831","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:54f2ed07-263d-45d0-8b58-4ef45dd9644b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3831","original_object":"UniProtKB:P30411"}
{"id":"3e2e9241-def7-4158-ad11-eb4b9fd0e5c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117951478","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:f2580339-3b87-4963-9cf8-89cc3d5082d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9607","original_object":"UniProtKB:P21554"}
{"id":"62133a8b-e51c-48e7-8e31-1dbda81a90bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5134","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:63b142dd-2aee-4a77-8171-d1a59bfc2c47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6699","original_object":"UniProtKB:P04150"}
{"id":"d760d79f-133c-442b-a197-ca7dbc3c3e20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91812","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:1d2c1af8-e77a-491b-b3ed-2627dd25da2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1273","original_object":"UniProtKB:Q9H3N8"}
{"id":"76547dfa-ccdf-4fef-817e-e6c6b126efe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623362","predicate":"biolink:affects","object":"NCBIGene:4319","sources":[{"id":"urn:uuid:2db97e1d-3585-4c92-9f0a-ebe578ffdc4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8259","original_object":"UniProtKB:P09238"}
{"id":"13630d62-3a9c-4d66-af06-c3b334fe0d12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136237316","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:cd99458a-569f-4fb4-bf21-a5a9cfccaf73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10674","original_object":"UniProtKB:Q9H2K2"}
{"id":"9b806d18-374f-4d49-afbb-216c2c3f8587","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122644519","predicate":"biolink:affects","object":"NCBIGene:886133","sources":[{"id":"urn:uuid:8faffb3a-0115-4a46-aaa0-f1864e49fc8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9645","original_object":"UniProtKB:I6X8D2"}
{"id":"efba819f-21cf-42f1-a27f-1fef2288e054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864283","predicate":"biolink:affects","object":"NCBIGene:11329","sources":[{"id":"urn:uuid:b8c01546-a918-4b77-9e65-5e5c1cd9c309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8209","original_object":"UniProtKB:Q15208"}
{"id":"fab06695-ac10-4333-b444-036d94fc23a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9062","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:211f4a43-0a66-4c61-ae68-0a5e5c0cb5d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12463","original_object":"UniProtKB:P59534"}
{"id":"899ef80b-018c-4429-b5ac-86f9733d102f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:0d782983-8131-4f76-8aa5-8d3c031f8a98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P31644"}
{"id":"d7f4008f-4745-433a-958e-33f9ef303d53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10106214","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:7e44ad0d-d6dc-4872-8313-46ad298d5b29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1209","original_object":"UniProtKB:P35367"}
{"id":"6c997d42-6398-4313-864e-c193dcb42b17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92874","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:6cbbe94e-06d3-4325-9642-dd0c81e3a8cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:966","original_object":"UniProtKB:P14416"}
{"id":"3459c9f2-aa60-42f4-b8d9-62cb74c1d641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:31D90UKP5Y","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:731df0dc-d36d-4717-a768-0df73989f996","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2862","original_object":"UniProtKB:P10275"}
{"id":"4a67ab8b-e397-4d9b-8bab-49482aaf2463","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31578","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:f3f5c653-1451-4b9b-bca7-2b53e5dddf88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6948","original_object":"UniProtKB:P10275"}
{"id":"e02d8081-898a-4e5d-802a-7202e93c9449","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136034","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:e033097f-ca19-4f6a-9903-f28ea172f4c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1324","original_object":"UniProtKB:P32245"}
{"id":"f84e4575-eec1-4906-8d3f-972a26835472","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59858","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:7412713e-f4ae-4a1b-9422-b19aac2b25b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6294","original_object":"UniProtKB:O75762"}
{"id":"b2aba563-34cd-4db7-8a04-fccfd2384d8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M7FHF24Q22","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:8b219c5e-3c54-4479-bb7a-8d7c1623d75b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:195","original_object":"UniProtKB:P28335"}
{"id":"9c935e99-3c85-4013-9a36-128ee528c208","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7487","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:ec57cbdb-cfe3-492b-a051-c6b802efeedd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7487","original_object":"UniProtKB:P08246"}
{"id":"3d0669be-eea3-4df3-8a39-d57f3dd3ce1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:97A09L5JCK","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:d1109019-c35e-4939-b1f6-8a5530d263a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10601","original_object":"UniProtKB:P48736"}
{"id":"035bb02a-4b42-4f11-a702-7fc0b6075d0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K9C42672RH","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:5b619e81-cc68-43fc-853b-94d9e96c1027","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8070","original_object":"UniProtKB:P43405"}
{"id":"74f0833d-aac6-4086-91f8-c5c9bbe19da5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228907","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:8471103b-b9a3-40da-a4d6-adadc921db59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2769","original_object":"UniProtKB:O75469"}
{"id":"c9f41068-a051-4934-8e48-1e171b4e78db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:263152d0-c35b-4731-8fbc-74a35ecf91f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P10980"}
{"id":"e9424fc5-3ccb-4ef8-bf2b-d133f6be377b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2706","sources":[{"id":"urn:uuid:d3491e87-e9e1-4f41-9161-78f28de268e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:P29033"}
{"id":"2222678d-2f85-4c15-8390-23e25e17730b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:930","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:6f0c1daa-8fd8-433c-b278-506251e2582e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:930","original_object":"UniProtKB:Q13324"}
{"id":"ec46839a-39b6-420c-9d36-7e57f189f119","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93359","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:622ca663-f9b0-40b0-92c9-2896e59969bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1255","original_object":"UniProtKB:Q9Y5N1"}
{"id":"a6c9b3bf-074d-42dc-8469-589c730a5a57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43871","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:3d6e1df8-e65c-483a-869e-d9611d529c90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5181","original_object":"UniProtKB:Q13464"}
{"id":"33207ff2-e22e-40a7-af6f-838ab18b37a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:26279","sources":[{"id":"urn:uuid:69da3eef-2b10-402b-be89-68bac42bc147","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:Q9UNK4"}
{"id":"7d67ae5b-f431-48cc-8556-b0e63f0563d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3360","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:87c1de9b-c1e2-454a-9626-7438ed3bd387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:740","original_object":"UniProtKB:P21554"}
{"id":"128a21c1-74e4-43cc-8038-6521f113e092","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1554","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:6de52dd7-166d-4868-befc-35a1efbda82c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1554","original_object":"UniProtKB:Q63447"}
{"id":"c4e77df3-2d89-4540-bc14-0712e14030a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24750192","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:51c37a4e-fdd9-416b-bc8e-4e5f5cde7082","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7777","original_object":"UniProtKB:P49286"}
{"id":"f8a3f81a-c36b-4ecb-980a-e9ca1a994afe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8899","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:f6630e62-aa81-4397-b8ee-ea170afd9b31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2611","original_object":"UniProtKB:Q05655"}
{"id":"5fb96ad6-6d50-4d53-85c0-ea75da660cf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133797","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:ddd04fef-71d2-44f4-ba89-1fd7ff87ef35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2311","original_object":"UniProtKB:P70605"}
{"id":"7475f296-9749-4b96-86a1-711a5545f5a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:6b3ff53a-bab9-4c98-8bb1-985c297375b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P08909"}
{"id":"e43888e5-6649-4faf-9f99-ab3e005778ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4345957","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:a052e77a-894c-43dd-9ffa-547057c6efa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:613","original_object":"UniProtKB:P30550"}
{"id":"82dd2ea8-8d16-42ac-9aba-a17e48877f30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129786","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:613bcf73-5fd8-4898-a3e5-837092f38a90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3276","original_object":"UniProtKB:P08482"}
{"id":"53cc4cf7-9625-4b4f-a2ad-0a6d8cac2c9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755065","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:de0a62ee-339a-49ce-bdd0-f1b6c1c40c0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3973","original_object":"UniProtKB:P32297"}
{"id":"b1de15a4-e14e-4fab-9ca6-702bce4d976a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91754554","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:7b12f2c4-fc1a-4aec-afe9-5f401a26643d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8481","original_object":"UniProtKB:P36897"}
{"id":"b20c3a49-1f75-4d7f-9611-06bc48899d6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:46D4HS9ODA","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:e68c71d9-6d97-4710-8c03-8546f20aedce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9903","original_object":"UniProtKB:P50613"}
{"id":"d874bb9b-b832-41bd-9c57-661b8b0d720b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277835","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:666a56f5-a0b5-47a4-ad7d-6975778507b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7757","original_object":"UniProtKB:Q969V1"}
{"id":"b5c33e88-0535-4511-be17-f37f4e9a578a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8978","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:6202f9f7-a4d3-4974-840c-41e9d1fff10c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:191","original_object":"UniProtKB:P41595"}
{"id":"335de482-01b9-4a5e-8daa-ab30f8ad6293","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:bffd4d46-18c6-4031-878e-fb9039aa71c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08173"}
{"id":"462b9bee-f1ba-4760-b88f-ca9d9078bf68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185787","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:e6764dbe-1924-45eb-9daf-c7241112111e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9706","original_object":"UniProtKB:P34972"}
{"id":"808a587e-0edd-4c86-a170-828f3ba30c2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3103","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:7197c398-8014-46fd-ba7b-690c7fbfe7b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2366","original_object":"UniProtKB:P48167"}
{"id":"75191115-a623-4cf3-80a8-8b5db3c01bda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16595","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:890b3070-7c19-4c85-bd85-f6ea25d11d51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4222","original_object":"UniProtKB:Q14643"}
{"id":"1a643d65-eb78-40d8-9328-b9b9a288b55e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2160","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:a10d2d32-4ada-4dad-b72f-29b14b93fae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2160","original_object":"UniProtKB:Q9UKP6"}
{"id":"a3560e5c-703f-42b0-987b-ee4cd3f308d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T5490K8I7S","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:be0f38f9-2d9b-4014-9aed-0aaec18961d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5948","original_object":"UniProtKB:P24941"}
{"id":"c35bc1fc-9d1b-498b-9139-fe14922eb3d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:74989de7-8b6f-4502-bb4d-5066819cb9b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:P51788"}
{"id":"c2cf3716-5d21-4278-8472-110c4cb13695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2614","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:d9be9034-d8dd-4931-be22-5d8894874e19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2614","original_object":"UniProtKB:P35498"}
{"id":"bdbffddb-6643-460c-8df0-abdd232b30f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135390719","predicate":"biolink:affects","object":"NCBIGene:3685","sources":[{"id":"urn:uuid:58da9162-07ea-40cc-b1ac-d14a3f4b88fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12108","original_object":"UniProtKB:P06756"}
{"id":"33d46944-91cd-4aef-a8f6-45f2b9669767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10286113","predicate":"biolink:affects","object":"NCBIGene:1360","sources":[{"id":"urn:uuid:491651ad-1264-47ca-bdab-0b343c44a165","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8623","original_object":"UniProtKB:P15086"}
{"id":"e15a5486-a7be-4a93-8e7d-06cfb3a38e95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X5DCA09N30","predicate":"biolink:affects","object":"NCBIGene:9975","sources":[{"id":"urn:uuid:a99a3eca-1cf9-4838-ac70-2e907d8f6eaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8901","original_object":"UniProtKB:Q14995"}
{"id":"f430dda3-6a56-4365-b10e-8029ba47803f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91346","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:e31dddca-872a-4988-bbb6-0f013ff6430e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5921","original_object":"UniProtKB:P31751"}
{"id":"2c6c111f-ec48-4439-a993-a71a70595002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8988","predicate":"biolink:affects","object":"NCBIGene:1312","sources":[{"id":"urn:uuid:8da951aa-6dc0-4159-9117-42f87cdc3dd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8988","original_object":"UniProtKB:P21964"}
{"id":"d4daf645-da14-4ced-adc4-cd9a75b9f370","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081958","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:9c21cdc4-5e67-4cf4-aa34-9070fbfbd2c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9845","original_object":"UniProtKB:P43114"}
{"id":"ff7f4213-7c46-4dd9-bf13-409959dd21bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15487887","predicate":"biolink:affects","object":"NCBIGene:839","sources":[{"id":"urn:uuid:bf5e74dd-cef1-4c01-b820-d7297cbd12c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8566","original_object":"UniProtKB:P55212"}
{"id":"1e5ea1b4-ed57-46a2-9fdc-9051a252f76d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:40","sources":[{"id":"urn:uuid:66e579ba-4bc1-4ea8-9ef9-2cd074084631","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4262","original_object":"UniProtKB:Q16515"}
{"id":"385e5629-8ede-4b41-b70d-8365c53f9af2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL285043","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:b3d6c279-5eaa-4cfa-9861-efb3c42196b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1408","original_object":"UniProtKB:P35349"}
{"id":"95a10d00-b101-4467-a88f-6053ea47ead5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52944985","predicate":"biolink:affects","object":"NCBIGene:23417","sources":[{"id":"urn:uuid:69b1d808-1942-4aff-98e2-ff91be52600d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8779","original_object":"UniProtKB:O95822"}
{"id":"c58154b7-6b4f-4e80-90e3-1378ac2617a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134480550","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:8a31502f-6fe3-463f-8d8f-2b2077d1eeef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12377","original_object":"UniProtKB:Q16288"}
{"id":"44ed996a-a8e8-44c9-bca3-0e7757a014b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:126eaee1-0693-4ace-84c5-aa1ac42bc3a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P08909"}
{"id":"9da1239c-ff09-4c5e-abf4-69ae727e92c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:27330","sources":[{"id":"urn:uuid:ff31c127-25bf-459e-b401-78ff6737824c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:Q9UK32"}
{"id":"96f8b55e-b1b6-4d37-bca8-7b60b3483262","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8970","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:721f5735-7fb3-495f-9b05-9b230cae7500","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8970","original_object":"UniProtKB:P48546"}
{"id":"4b832caf-4b15-4caf-b718-fcdb40948572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5689","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:9695f29e-7286-41e3-81f5-aab9e579e05b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:736","original_object":"UniProtKB:P34972"}
{"id":"e8801020-228c-4747-a0cc-5151e6e36921","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7S06P17S1V","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:23fb584d-bc3a-4da3-b6a1-d6f805ccbf42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12430","original_object":"UniProtKB:Q9NYW2"}
{"id":"4e4cac5b-cac7-4077-9f56-e183ba8938de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154025209","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:ec889488-ad8c-431a-9e70-1b35ba633add","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11192","original_object":"UniProtKB:P09619"}
{"id":"f6e6f408-041c-48ce-aedb-2c7911edeae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122705989","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:be6a8fcf-2796-4b5a-b82d-89ca52daa613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11980","original_object":"UniProtKB:Q13164"}
{"id":"2ca75218-8950-4972-b648-f14d3813c370","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7R7G6EH5UL","predicate":"biolink:affects","object":"NCBIGene:4193","sources":[{"id":"urn:uuid:e4104d1b-ca64-45c1-b7f4-de81f847b028","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11133","original_object":"UniProtKB:Q00987"}
{"id":"b0458d8d-ca3f-4c08-9a59-9ec804ac67b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:c68510c6-ce84-476d-94b4-f74c532e8a95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:P30872"}
{"id":"0594e208-dbb3-4a63-9d32-2777e80d5c21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:57J06X6EI0","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:a771b20c-c23e-46bf-8cb3-af028dc1e5b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10654","original_object":"UniProtKB:P13866"}
{"id":"669ac398-a70d-4d70-ab69-115628fd3962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190326","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:6f3ebb5a-46ee-442f-978d-c6217af4fb00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:731","original_object":"UniProtKB:O75311"}
{"id":"747100a0-4be5-4fe2-b85f-40027373d121","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:f4c19f18-df3c-4204-aef9-3f8be059f078","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:P42681"}
{"id":"e5d3e70b-ff3d-4b5d-9fb7-2bd9dd33573f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439089","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:0ea526ce-334d-4dca-b576-836151853584","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:443","original_object":"UniProtKB:P29275"}
{"id":"8a50a4bb-18c0-46ec-a4cc-0c2b7b7d5923","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8734","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:09a10572-4582-4f84-83b2-796df2cacf81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1372","original_object":"UniProtKB:P23385"}
{"id":"c20ac137-c80d-4f5a-a2fc-deda4cba4d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817484","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:ee448470-18a8-458a-b43b-8512092c4e29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6117","original_object":"UniProtKB:O43603"}
{"id":"1c59d11a-e633-437c-a9e0-9ef8e912c346","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221652","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:8bf716c6-3e0e-437a-baac-f4c2a5a5be9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9471","original_object":"UniProtKB:Q15391"}
{"id":"539271ef-54a5-4b6a-91f5-789badef2fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5810","predicate":"biolink:affects","object":"NCBIGene:319239","sources":[{"id":"urn:uuid:8edb782f-a658-4c55-b856-e956e0ad164b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5810","original_object":"UniProtKB:Q8BZP8"}
{"id":"354c2891-ce78-4214-acb0-9b90990027c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:51dc35c2-8a5b-4a72-8c81-a385f02ac44f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P08908"}
{"id":"23218e56-7845-4948-8e12-78331fd796ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FGZ6L9SF2","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:6bae775a-475d-487c-a824-6c5fc75520a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9055","original_object":"UniProtKB:P32238"}
{"id":"ac66f274-ba91-4add-94be-806c438c67c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91654625","predicate":"biolink:affects","object":"NCBIGene:29994","sources":[{"id":"urn:uuid:c70d1bee-fbad-490c-87d9-c35d3aa24fd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8571","original_object":"UniProtKB:Q9UIF8"}
{"id":"8f6b454c-3bcf-445a-8583-1bfcc55c6392","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135531","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:f5e8d3a5-358a-4029-9f63-27d59130d126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:354","original_object":"UniProtKB:P08172"}
{"id":"05ef9e11-9464-4b9d-8edb-88089f15741e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277838","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:27bff678-fb56-40ae-bd32-fa70e6d262be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7773","original_object":"UniProtKB:P48039"}
{"id":"a2104da1-869e-4637-aa3f-5ed88062fc01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146018968","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:8c419ef7-f04a-474c-9c77-a728e4f98597","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12525","original_object":"UniProtKB:Q9HCX4"}
{"id":"144bbeda-bc19-4b09-a357-712779cea845","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78030","predicate":"biolink:affects","object":"NCBIGene:64840","sources":[{"id":"urn:uuid:37f6e265-cbb6-4554-b901-fbe9a21ed02b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11167","original_object":"UniProtKB:Q9H237"}
{"id":"36d4493a-9209-445d-bcea-c501d3a51615","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817435","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:a1363c54-79ad-47e5-b5fc-62e5e592a58b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1875","original_object":"UniProtKB:P49683"}
{"id":"86fbbdb3-7371-4ebb-8d74-3d5da111f510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11957582","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:4933b0c5-2608-4a4a-96f8-e37d7ee5179e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5231","original_object":"UniProtKB:P35228"}
{"id":"6c35e507-3359-4c9b-b696-8c80b4d52cfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134585358","predicate":"biolink:affects","object":"NCBIGene:20273","sources":[{"id":"urn:uuid:36965f52-debf-4724-8335-1cbd0a3fb368","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13387","original_object":"UniProtKB:Q9WTU3"}
{"id":"ce9e46c0-1630-4249-affb-a5a113325403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35046","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:fc6ea37e-ed04-4ac8-b389-4b98ecf327b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2596","original_object":"UniProtKB:Q9NR82"}
{"id":"25e78886-2cba-410a-94cc-80a1d584cc9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:770","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:bc683c72-f0bf-4a69-a1b4-e1b83f71a345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:770","original_object":"UniProtKB:P51677"}
{"id":"eab3d29d-fd50-408c-ac80-a22100b8dba5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3729","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:458a79e3-9772-46b2-871a-ed93530a4cca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3729","original_object":"UniProtKB:P25024"}
{"id":"35e5d462-4d9f-4d3c-b813-8f1167d2f8ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:68fe8ded-332a-4aa5-ab3e-82fed913b32f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:P06239"}
{"id":"daa50a45-3e4a-46d1-abe0-775937864e37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131169","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:8a0b46c4-c6fa-4789-a6aa-c6c621894a51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7795","original_object":"UniProtKB:O00329"}
{"id":"dcd045de-b7e4-4889-a62d-6198ae1f0951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92229","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:14171f4d-5ada-4e53-95ec-e07fc8d9bc6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3302","original_object":"UniProtKB:P21917"}
{"id":"d7848398-b1ba-4a27-b446-f4a28216ec86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:74MLR03FLC","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:034bce40-9a3a-46a7-9e20-7810aae59db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:63","original_object":"UniProtKB:P08588"}
{"id":"fc37e82c-594c-4e01-ae29-4c1bacfe4d93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311453","predicate":"biolink:affects","object":"NCBIGene:21390","sources":[{"id":"urn:uuid:fb53c19d-3181-4cee-a62b-5188b62d8efb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1939","original_object":"UniProtKB:P30987"}
{"id":"32eea03f-948c-42df-b1bf-f81637da23ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50905018","predicate":"biolink:affects","object":"NCBIGene:9572","sources":[{"id":"urn:uuid:4d812bfb-e44b-4f72-8e1f-fba75825044c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2903","original_object":"UniProtKB:P20393"}
{"id":"00b37f1c-aa80-4400-96a1-426b3fc8a2e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23035251","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:974413f1-ed16-4484-acd5-b2b6c7b155be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13531","original_object":"UniProtKB:Q86WV6"}
{"id":"4a8de80e-147c-4256-a329-c95536015008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95129","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:fb705944-3ccf-4d94-9647-744ddfefaf21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:240","original_object":"UniProtKB:P97288"}
{"id":"68eff2e4-3668-429a-be74-e84a1d481cfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OVW60IDW1D","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:41870227-9c5c-4480-b5b0-94581f6d9cbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10096","original_object":"UniProtKB:P42336"}
{"id":"bb293160-97b4-44a5-9da1-9215220aa82c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:1969","sources":[{"id":"urn:uuid:6ffb6d8e-1b07-413c-a2f3-43d764fc96ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:P29317"}
{"id":"b608bcda-b01e-48e9-bf8d-71fdab002bac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2228","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:54edd91e-bc23-4d21-a0ee-f1982a08dfc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2228","original_object":"UniProtKB:P30518"}
{"id":"f9eeaf43-29a1-4dbc-ba6a-499971992acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:445d199d-be2e-4bb2-b8fc-6ec5841f827f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P23415"}
{"id":"95c229cc-0246-483e-af27-dd2761936f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:d6a5815c-c320-4ecf-a179-abc33ff5bd13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P32304"}
{"id":"18ac1301-4ed8-4d4d-99ed-eca7ea3ae5b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4ADT8JXB9S","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:434f3d81-aeea-4535-980a-962b394619e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8948","original_object":"UniProtKB:P25025"}
{"id":"74c7426b-da5b-4a2c-a0d0-5965731b7a1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7507","predicate":"biolink:affects","object":"NCBIGene:24247","sources":[{"id":"urn:uuid:295cd352-0844-49c5-a5e2-04ab2d0c83cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:709","original_object":"UniProtKB:P48442"}
{"id":"bbafd9e5-a5b8-41dd-bd60-5cb02981d94e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755219","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:685c65a3-fb3a-4017-af6d-fffc67471d46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6426","original_object":"UniProtKB:P31424"}
{"id":"db659b54-67d3-42bf-867f-d87bc3e2d06f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16144017","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:4ad14843-56dd-4efa-93f7-f2466247d800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1822","original_object":"UniProtKB:P49190"}
{"id":"6a50fb45-14c3-46c0-ba49-471b4403f11f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60150890","predicate":"biolink:affects","object":"NCBIGene:24925","sources":[{"id":"urn:uuid:009e9136-4bc9-4f86-ac6c-fc70ceba58fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12580","original_object":"UniProtKB:P18090"}
{"id":"9a7af843-a78c-4ea7-aea7-0a6a088a008a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:e0ccec4c-b5f3-4c53-96d3-87678b98cc00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P48050"}
{"id":"9545d401-07cd-4737-b494-dcd6b9221d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2024","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:62d5a929-eb32-4532-a43e-157238392dc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2024","original_object":"UniProtKB:P35346"}
{"id":"ebb5850b-9a16-45fd-92f1-b90ac5411e2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T77D5438IM","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:bd097269-01de-4cb7-bbf2-387ad63bdcc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5831","original_object":"UniProtKB:P33766"}
{"id":"9065f8ee-9576-4108-929a-ea8f7e00505a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53344810","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:cca6be20-6b9a-4d88-b146-7183443d8443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7716","original_object":"UniProtKB:Q99835"}
{"id":"b6bb08c8-c217-426e-a00f-ee8e4a46a9a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:5fcf838d-d495-4e2e-8230-fb03b3a7602f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:P17948"}
{"id":"01914b87-91be-41cd-b1b9-86605ff18c2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311175","predicate":"biolink:affects","object":"NCBIGene:21390","sources":[{"id":"urn:uuid:4054d273-67e2-49f1-b7e6-60fc71874d91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1938","original_object":"UniProtKB:P30987"}
{"id":"2d3c408b-232f-419d-a732-bc63885a3ef4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c641e866-6a33-47be-89bf-bc56fcfbf618","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P28221"}
{"id":"e3b887d8-905a-40ab-a10b-ad89eed53e56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W71J4X250V","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:c0377ace-ec43-4b5e-8bee-7f947114bec5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8382","original_object":"UniProtKB:P42336"}
{"id":"b5421d4a-4b24-400c-b4e5-65372de5a31a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94411","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:dae2742f-8ca0-4168-a106-8af66ad1383a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10470","original_object":"UniProtKB:P08173"}
{"id":"9b9bef44-44a7-4770-a1e6-468500bad322","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91495","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:ef1bf694-4925-4a12-8833-eb293a35b302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:325","original_object":"UniProtKB:P11229"}
{"id":"ec32ab1b-7a01-4c88-a325-cb78f0e77190","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0ICW2LX8AS","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:339371ec-e88f-4e8e-a300-cc73260edf8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10478","original_object":"UniProtKB:P30530"}
{"id":"050b92ee-6f40-4563-899b-72352f30c1a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9472","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:9af7c20c-2e20-4df1-99ef-7b1a3f230809","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9472","original_object":"UniProtKB:Q9UGM1"}
{"id":"b8927c97-e971-4c0b-965b-1a14cfdcabd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2613","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:bf7af63b-1f62-40e4-8e9e-5a2cebb9f9d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2613","original_object":"UniProtKB:Q9NY46"}
{"id":"54aa38cf-cd49-47ed-9836-24de16525926","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2178734","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:3667583b-d7fe-4c88-9a06-c3cd5a8c097b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5974","original_object":"UniProtKB:Q00535"}
{"id":"23f2f03c-7fb2-4142-a7e0-9be0af363c8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:821","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:f8d39791-7465-4702-be78-b6b0c6be5b80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:821","original_object":"UniProtKB:P25025"}
{"id":"dcb4255e-264c-43b9-b302-e5df8a3ba74b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125354","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:4ed5ddb5-0fff-4bf5-aeb2-098ed3e29ea7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:844","original_object":"UniProtKB:P61073"}
{"id":"604c07a8-d098-4d17-9577-54ab8aa00d78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134990","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:2fff5758-3589-4a37-829b-b65b14f0803f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:198","original_object":"UniProtKB:P41595"}
{"id":"212fbeb2-49ff-4a1e-8278-8f61cc6f76c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34725","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:58071ae4-a0aa-417c-aa4e-138cc8b0dafe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2403","original_object":"UniProtKB:O15399"}
{"id":"926613fa-ae9d-422b-bd17-b5443039bb85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137222229","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:1c2a54e6-aa25-4169-b31c-8dfcc17ae64f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9622","original_object":"UniProtKB:Q14833"}
{"id":"b2b77e39-d089-42bf-a91e-f5968585b8a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23399992","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:bd61bd73-bef0-4f48-b4c1-935d93cdb737","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4096","original_object":"UniProtKB:P28476"}
{"id":"72779234-b6f2-411b-8451-b36ce83906cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103966","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:b1817017-4f02-4020-b041-6699f338b70e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6077","original_object":"UniProtKB:P21728"}
{"id":"a2fd38f7-5bc1-477f-b4ce-4f0730364b72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6131","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:045026d4-077a-4687-b878-754b3dad4a6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6131","original_object":"UniProtKB:O08726"}
{"id":"fd9f029f-0227-4947-a353-78f15573d153","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:427518","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:09c8c2d5-1f16-4c50-a909-78ab10e6771c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11239","original_object":"UniProtKB:Q9HBA0"}
{"id":"5140f978-759c-4c3d-8926-05453385c57b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755084","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:3177cdf5-04b4-4f8a-a09d-957ed5f43ef2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4188","original_object":"UniProtKB:Q9HCF6"}
{"id":"e3a52dfb-115c-4525-abdc-a4d09be0833d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1796","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:340109e3-0a93-4fd0-8564-bed7e8ec3ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1796","original_object":"UniProtKB:P25961"}
{"id":"44a1f72f-01d9-48b4-8d58-4966152b7be8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:edfc31f5-0df8-4cbc-a47e-69f9e9d8f0f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P35968"}
{"id":"f704ab4b-58f9-4122-a3ba-d2438164abe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801164","predicate":"biolink:affects","object":"NCBIGene:12777","sources":[{"id":"urn:uuid:beae12a1-ad8b-4314-a06f-d9adfcd3d11f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9714","original_object":"UniProtKB:Q9JL21"}
{"id":"0ddea3d5-81ce-48d7-b1bb-28d40a1c6e44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755085","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:dcf4d7a2-dc88-4586-a144-869c61da51d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4201","original_object":"UniProtKB:P23415"}
{"id":"b851dc4e-f1b0-4d88-91b0-cb2efe472aa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:140700741","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:32b1ff5c-706b-4915-80e7-e7d46e57db6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12819","original_object":"UniProtKB:Q9NQS5"}
{"id":"49b2dcf4-e86e-4b68-98f6-9f7d2348d92d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10344307","predicate":"biolink:affects","object":"NCBIGene:4324","sources":[{"id":"urn:uuid:e643ddac-0081-499b-883b-063621bfb942","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8629","original_object":"UniProtKB:P51511"}
{"id":"9715566d-288b-4465-9b7f-5a1ad40c43e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135524168","predicate":"biolink:affects","object":"NCBIGene:8550","sources":[{"id":"urn:uuid:29e478d9-2acd-4655-9e9c-8d50a4934b63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8178","original_object":"UniProtKB:Q8IW41"}
{"id":"b5928fc9-8787-4930-8ca6-cd3413ba9c8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9827261","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:5fcb63a7-9dca-4bed-8f14-1d272088a4cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2665","original_object":"UniProtKB:P37231"}
{"id":"539aafbe-43e7-4614-bc5d-f907fa538335","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:fd4f46e8-4f81-420e-b32b-8d7e8f5400ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:O95069"}
{"id":"e581e639-92c5-4131-9905-fdc7305eb92b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3BY9Z3M34G","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:e3b54199-d4df-477c-a26f-3dc01854be35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10744","original_object":"UniProtKB:P29597"}
{"id":"e4327559-6cbb-4860-86cf-921d0ed47a95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8874","predicate":"biolink:affects","object":"NCBIGene:590","sources":[{"id":"urn:uuid:9f063f3c-2f81-40cc-af57-10d926efce4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6602","original_object":"UniProtKB:P06276"}
{"id":"0386e99f-6412-44a4-a424-184ca70471fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6H35LF645A","predicate":"biolink:affects","object":"NCBIGene:25590","sources":[{"id":"urn:uuid:34b63c20-1612-4c17-963c-686c381e2c30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3994","original_object":"UniProtKB:P09483"}
{"id":"559da168-fdd5-4a55-8f4c-7d61fb8e216e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49375","predicate":"biolink:affects","object":"UniProtKB:P57059","sources":[{"id":"urn:uuid:1986c946-8918-4fef-bc12-4019b897e77d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5678","original_object":"UniProtKB:P57059"}
{"id":"5a6be617-9fec-4596-aca0-e3b44914f11c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59896759","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:08e20c89-dde5-4a98-8784-ee8a419c7d32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4369","original_object":"UniProtKB:P31644"}
{"id":"f9ce2545-110b-41ff-97a6-51268fe54467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136538","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:3551c4e8-2a1e-4e7b-803b-b3e92959da8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4186","original_object":"UniProtKB:P08913"}
{"id":"5b2559c6-0777-404c-8206-f79316fb56ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4943","predicate":"biolink:affects","object":"NCBIGene:2690","sources":[{"id":"urn:uuid:432d9aab-4306-4d92-b0a6-cdee2a37f137","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4943","original_object":"UniProtKB:P10912"}
{"id":"b85eaa45-fa51-47ec-8cd7-56677eda1bf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59896759","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:cae38be5-c66f-40d9-8fa5-cb965e44ad78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4369","original_object":"UniProtKB:P14867"}
{"id":"edf8024a-0777-4877-ba63-2258f53e20e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46173038","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:ae46da63-9593-46c4-93a6-269db62e428d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13266","original_object":"UniProtKB:Q04771"}
{"id":"1c5a5d2e-6a3a-4c67-b976-a3f125991b3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5770","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:2702e04b-4087-4a4c-bf93-fa2def6ec77a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5770","original_object":"UniProtKB:Q9P296"}
{"id":"4177b84a-2531-44aa-b916-2356ef02a2d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M371870BYL","predicate":"biolink:affects","object":"NCBIGene:3758","sources":[{"id":"urn:uuid:896ecd30-d161-4af1-b1c0-4571d0355085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10382","original_object":"UniProtKB:P48048"}
{"id":"13a71ed0-7c72-43cd-a096-55cf12173777","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:b8671e27-1953-45e6-a80b-425e4061bdb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P14867"}
{"id":"92d07fc4-c1a5-414b-9401-179febfbe5d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EOB0N7BOY4","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:99ca8633-c6d4-4f4f-a588-df330fdc4544","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13215","original_object":"UniProtKB:P36888"}
{"id":"34db8dfe-64d8-44bc-b971-a6c0d73ab403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131166","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:55bd24a0-90c5-41a5-b8e9-22b7b5cc65b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8003","original_object":"UniProtKB:Q13535"}
{"id":"c704463d-62c0-4e3f-b20f-4f4ec85654b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:095e6cb9-a12d-44ba-84a0-3c73f91df403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:O60285"}
{"id":"794cc808-76c6-46b3-b6c0-b5f6db96cabf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64131","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:49900a9d-b978-4dda-a9b8-50ab3ba96519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:73","original_object":"UniProtKB:P30939"}
{"id":"e68ea5b8-56be-4773-9c93-b37859428c5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4284209","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:87fc27c7-778f-4aa4-8717-a20ba7b583cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10081","original_object":"UniProtKB:Q00535"}
{"id":"93353882-a262-4bd6-a2f3-c24d143f014d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47781","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:9c45f940-0b9d-4927-a230-a9953fe2fea4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2399","original_object":"UniProtKB:Q7RTT9"}
{"id":"ce183ab1-0ff1-41f5-bb71-9a1a3ddc1f51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:17b28a4e-8fbb-4aef-aa79-4334f5aebe07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:Q02763"}
{"id":"9d90af22-a4f4-45ad-a2ce-fecae9ba1827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23661671","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:e00c89a3-6374-4f0c-87cd-8905aa7eb449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6444","original_object":"UniProtKB:P31424"}
{"id":"2915e0d5-85cc-4ba2-b35e-10a1a4415b18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:653","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:8428869a-7836-4a6e-84ec-c736a1b295e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:653","original_object":"UniProtKB:P46663"}
{"id":"125a7d11-ea28-44ba-a20e-4329488ca55b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11607","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:347ac392-fca1-4c05-b910-e355d0932802","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11607","original_object":"UniProtKB:P10721"}
{"id":"573bfae5-4675-4c96-a9ba-6f4a70074368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16980","predicate":"biolink:affects","object":"NCBIGene:29465","sources":[{"id":"urn:uuid:2db21451-2052-46bc-9f34-a82ae0388cf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6327","original_object":"UniProtKB:Q9WUD2"}
{"id":"46c526bf-8eaa-4b6a-bd5d-e37f8a43c8d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9796408","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:aa66365c-bc87-45f7-9212-bb34db096d16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:170","original_object":"UniProtKB:P41595"}
{"id":"d053cc89-ba33-4691-87ae-5ec176d872f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233327","predicate":"biolink:affects","object":"NCBIGene:1491","sources":[{"id":"urn:uuid:0c4dcb98-7352-4eed-8f54-63e1231ba0ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5247","original_object":"UniProtKB:P32929"}
{"id":"4e90fa8e-55d9-4e75-937b-d6230653fe21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947027","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:25067f0f-c030-48c7-a601-4008f38fe0b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3003","original_object":"UniProtKB:P04035"}
{"id":"edc3f53f-0fc8-4b8a-80ac-392124d572cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9995893","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:62224865-a821-4110-81ae-d9b172d9dba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:65","original_object":"UniProtKB:P28222"}
{"id":"7abbcd99-05a0-4cf7-8c12-a6b017c28591","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103931","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:6d37b8bb-06e1-488c-84d2-30e1837eac00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:487","original_object":"UniProtKB:P43140"}
{"id":"1e4e1d1e-abed-4eb7-abfa-3bd6da37c8fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10200844","predicate":"biolink:affects","object":"NCBIGene:40","sources":[{"id":"urn:uuid:9d6a06f9-5749-44fc-aa87-dcce98cea47d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4116","original_object":"UniProtKB:Q16515"}
{"id":"f859507c-d624-424b-9343-e4f32650bef7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559101","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:19e1751a-3a49-4f15-9e6a-eb5a42c81d7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:259","original_object":"UniProtKB:Q62758"}
{"id":"77d14c01-aef6-4543-88f2-1413fcf27a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9RL37ZZ665","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:1432ed0a-ae8c-410e-9789-62c580e7a398","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7816","original_object":"UniProtKB:P35968"}
{"id":"9ed9b6d5-c99f-449c-a129-54e15524ebf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16761","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:dba177ad-810f-4fc5-a2e2-fb012ce6f8f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1712","original_object":"UniProtKB:Q9H244"}
{"id":"0d45440e-3769-49f1-b265-8f98be7a22de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:30eae46c-f135-49bf-a756-1a7dcad4c35e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:P56479"}
{"id":"8d5c11d5-5d4b-45ce-8554-25d0d30224f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91807","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:242bd453-3bd5-4420-b34e-cad23d29296b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12578","original_object":"UniProtKB:P13945"}
{"id":"d6945148-3cf2-4485-8621-1a352ca346f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368938","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:73638dda-e156-47da-954f-ddb80f312996","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12216","original_object":"UniProtKB:P31749"}
{"id":"5f614d15-bafe-45ac-a617-28b569cf0d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46899577","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:e30cfe3f-4adb-45f0-83d4-989e5bcda1e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8670","original_object":"UniProtKB:O15393"}
{"id":"5a737a20-c83e-49e6-b2e4-6f938e24edb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124990","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:2c8d0dd7-a9ed-40af-9a27-2b883ca3ce9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9567","original_object":"UniProtKB:P32300"}
{"id":"e1627fd5-4ae0-43af-9590-b1c74deca692","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64131","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:56ab1dfc-537a-44d3-acc0-051a80181568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:73","original_object":"UniProtKB:P08908"}
{"id":"e41bee88-49b2-43ac-9962-c03bea89bd12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3441","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:6c9929d9-77f2-42de-822a-df6d121a7861","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:551","original_object":"UniProtKB:P35348"}
{"id":"68172733-78bd-4ef5-8623-db710c7bb982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:772","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:06151841-01a8-4d62-888e-46f2bdb1d662","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:772","original_object":"UniProtKB:P41597"}
{"id":"be62a116-dd04-4a1b-b07f-697a2b365fe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:181461","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:c2b6945b-12a2-4307-8bc7-930254aeaaa3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1232","original_object":"UniProtKB:P25102"}
{"id":"86570659-8395-4122-8968-408f12e2ca3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755220","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:d11355f4-456f-4a51-802e-630a432b3ec9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6430","original_object":"UniProtKB:P31424"}
{"id":"77a0b48c-9be2-4e70-b3cb-e0a44c229326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1522","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:51de92e3-6aed-4133-b2a9-897d85e68aa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1522","original_object":"UniProtKB:P50391"}
{"id":"1468b72a-34e6-43e8-b164-03dd9065d3f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6402","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:295049bb-cbc7-454f-ba5a-c1b3e8831b9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6825","original_object":"UniProtKB:Q02127"}
{"id":"b59753e7-fb8e-4b45-9e27-74e68c167c1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:9de6955b-89c9-4b0f-bb4e-5ea9207c351b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P30543"}
{"id":"443ebb64-335a-4c32-b44a-c9827f9a1122","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71890885","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:150f40ac-953c-4dcb-879b-f97464456732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12663","original_object":"UniProtKB:O95835"}
{"id":"f73ba623-1d57-46e2-a897-86746e4ba482","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:219770","sources":[{"id":"urn:uuid:db462ce6-5dcf-463c-9da0-38e57ecbbc23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q96KN9"}
{"id":"d1bf7296-8174-4aa6-ba0d-51bd8d439d06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132427687","predicate":"biolink:affects","object":"NCBIGene:7941","sources":[{"id":"urn:uuid:ffab075a-fb6d-4adc-8b0d-5a0ca379cbcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9797","original_object":"UniProtKB:Q13093"}
{"id":"da5f6348-5c16-4c22-8194-df63e8441f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755184","predicate":"biolink:affects","object":"NCBIGene:12209","sources":[{"id":"urn:uuid:734b7507-f941-4cf3-82e1-3ae23887534f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6192","original_object":"UniProtKB:O54798"}
{"id":"a3bc4b02-a6fc-4d6a-afee-65d3452be4e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:9f930702-a66c-4a09-af91-c9dbf1fb2a5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P08908"}
{"id":"578e7f21-77e8-4fad-943f-cca078c03493","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:576087I4XG","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:904145b1-ff38-4e2c-9367-c73dfc941808","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:358","original_object":"UniProtKB:P10980"}
{"id":"3cf08171-e5ba-4b2d-a067-d1ca6b491855","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5697","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:ad066999-5069-4d53-954a-4a2eebde87c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:404","original_object":"UniProtKB:P29275"}
{"id":"8eadac47-566b-4a4b-85a9-ed4d434cce01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232985","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:bdd04bc9-d53e-4a9d-ba04-bd0c7d1558c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2318","original_object":"UniProtKB:Q9H2S1"}
{"id":"e4ce4a22-bea3-45a0-af6f-ddf7d52375a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1341","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:02545c7c-bd56-4216-88dd-1e81a57160bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1341","original_object":"UniProtKB:P32245"}
{"id":"e1d00bc7-76f7-43f1-b789-b3e0b87a62dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6888","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:033a2f15-0971-4ccd-9235-4177bd21f675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7088","original_object":"UniProtKB:P04150"}
{"id":"bc30bda3-36d2-4727-b1c9-78641c2887b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12690","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:0cdcf818-f5f8-45c5-8094-acc35e01b862","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12690","original_object":"UniProtKB:P11836"}
{"id":"7153ce77-d439-41da-be46-9aba993026eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126970680","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:03fa2dab-1004-41cd-b4ae-db99562343be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9516","original_object":"UniProtKB:Q06187"}
{"id":"e57b574c-555b-4632-b5a6-e63928d2c345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53378752","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:938a5f9c-6168-4721-95c1-d4e86fe53c78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10283","original_object":"UniProtKB:Q13507"}
{"id":"def5c53b-7041-4a17-8279-4e0f8f1295cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:659fbd7c-9843-46e1-b1cc-5d835fa29da5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:Q8TDS4"}
{"id":"e4d81ef4-41bb-4c5c-b27b-0d7a468b155a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868452","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:616cc21e-2642-4015-b62e-bf6bfa24cf3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:129","original_object":"UniProtKB:P35462"}
{"id":"6f4ac059-ccec-4f18-a45e-a525ee4ac148","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:854ade03-0f24-47f3-8c9c-5d66efd30c46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P28335"}
{"id":"453c3507-1c68-46a3-8c68-5b141a044dbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:322ca12d-bad8-486f-9ac5-9f5b7ea972e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P35916"}
{"id":"8f8a3e26-5190-4b85-82ed-e819e268d1e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:3e6ef522-c568-44cf-9442-0e88fbfc5967","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P32304"}
{"id":"a085f78e-2a16-461b-ae46-7a411af33a93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6788","predicate":"biolink:affects","object":"NCBIGene:2153","sources":[{"id":"urn:uuid:fb4c42c2-48fd-4bf3-a0e4-147c2c93b5c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6788","original_object":"UniProtKB:P12259"}
{"id":"7285c81f-25e2-4233-b2e1-eccc32bb58c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1575","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:d728cea4-fd79-4bc4-b13b-80a2640aff16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1575","original_object":"UniProtKB:P20789"}
{"id":"adb35d21-c98e-4297-a4c4-86cf8f882e38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:78d60f32-8144-4520-b302-2e26f70bcb55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P35368"}
{"id":"9fdf82cd-3523-49c4-b859-c0e901c94f72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:aaa969df-b86d-4a80-b8bd-fd504a51539a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:Q15858"}
{"id":"dfca8513-a533-4ac3-bc70-1e0a5efb9ea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4178","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:b30dc967-3912-46bb-bac8-d094c5ea0a7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4178","original_object":"UniProtKB:O35433"}
{"id":"600506f8-ed47-4a6f-80bd-11e4b21b9abe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321959","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:55ed739f-22e7-4b36-9793-087a29747289","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:131","original_object":"UniProtKB:P28222"}
{"id":"6658d10c-a5ec-4842-84e0-329326386a55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135531","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:0c9d437f-1cc7-484a-ade7-2651f115d84c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:354","original_object":"UniProtKB:P10980"}
{"id":"49208661-d950-47d5-9d90-af9fee5798da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57654476","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:9fe5ab9d-8711-42c7-ab98-67352ac70744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10507","original_object":"UniProtKB:P08581"}
{"id":"aae7b1f8-d2d9-44c7-904a-694e40a9a963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9622","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:d20b803b-8c83-49c4-9ca8-a8371ac19406","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:360","original_object":"UniProtKB:P11229"}
{"id":"6ea5ee77-85ec-483a-b491-b392c09f6f5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8925","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:03075f2a-3abf-44d6-a947-684a38009077","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4303","original_object":"UniProtKB:Q92736"}
{"id":"54e6df2f-a1cc-453c-b952-c71c21d946b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SHA6U5FJZL","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:c1b8f7e4-1f6e-49ba-9160-66bdaf51ce27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13695","original_object":"UniProtKB:P13569"}
{"id":"e3ccc8aa-e4b4-41ec-a532-190b771f482d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2041","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:e6ec7ecd-1eef-49e4-9765-5804c8789471","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2041","original_object":"UniProtKB:P35346"}
{"id":"52674a7c-7b44-478e-91c6-b92d6f77d02c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94691","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:293d908a-b0ff-48b3-bc73-c4e979de06c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5715","original_object":"UniProtKB:P42338"}
{"id":"79d583c4-7e26-4fda-8557-30c8d169323c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76328936","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:f1d0c70e-7c46-40c9-98cf-5698ec8652cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7919","original_object":"UniProtKB:Q5S007"}
{"id":"140a53a0-e28a-4049-9b45-e89e31362ffe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:640ac96c-5cb6-4ff4-a3a6-b88dc089c57c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:O00222"}
{"id":"85da9e70-7c3d-43c7-939c-3939b1d88c0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4779","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:ff5b010f-1693-4e0c-86b8-a317abc60bb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4289","original_object":"UniProtKB:P23415"}
{"id":"f2032a71-f786-4dad-abc1-1772fc6ed187","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9861","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:62f56c32-8dd6-4437-83da-1ac78bdc07fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9861","original_object":"UniProtKB:Q06187"}
{"id":"99057454-6503-48fe-9a21-bfe5691c7b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46868971","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:ef46ea12-a54d-46b9-a22b-ee5603154243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8159","original_object":"UniProtKB:O14757"}
{"id":"57e16a95-2ebc-431e-845f-f299bc496de1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8613","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:638d97e1-1ac1-40eb-ba0d-1ad3c267b27b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11291","original_object":"UniProtKB:P28223"}
{"id":"1e2fc997-8bdd-4690-b29b-609cda2ba3db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553159","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:f4c9d5e0-1a82-4396-ad80-cfb2f279cd4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10218","original_object":"UniProtKB:Q9NRA0"}
{"id":"dffc21bd-c91d-4162-be27-6986803ff471","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11418","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:e939365b-de2e-4605-846b-d8ce55aabae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11418","original_object":"UniProtKB:O43603"}
{"id":"54cf096c-2e9b-49e1-b8fc-da7eddfb6940","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:92b92e67-2ea7-493f-b83d-9522aca7f63b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P51451"}
{"id":"26bdbaf3-ef2a-4e0f-90a4-8cbbc09bf75b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16761","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:f635903b-19b0-41e8-805a-fa6cae37ebeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1712","original_object":"UniProtKB:Q15077"}
{"id":"a88d75d4-fd15-4c72-9793-b7c9673a16bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9916412","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:9b23bea0-4960-4faf-adcf-5ef406839798","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:665","original_object":"UniProtKB:P46663"}
{"id":"a4b37bc1-f237-44b0-a310-379c04e3702b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3603","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:e0a4517b-4a76-4307-9994-c25f2e5c0803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:308","original_object":"UniProtKB:P08483"}
{"id":"9e0c2ba1-1f5f-4307-ab2d-6305467edecb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:ba1a65aa-6a82-43cf-b274-6de20d64ccbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P30543"}
{"id":"46e7214f-9b7b-4e5c-8d88-f60ec2f3ac31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124141953","predicate":"biolink:affects","object":"NCBIGene:11156","sources":[{"id":"urn:uuid:dbfe6e4c-b842-4a4c-9640-5d0c50ac6b9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12480","original_object":"UniProtKB:O75365"}
{"id":"df33c473-e293-4dba-8d53-ae3427ad1707","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93701","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:743a2287-44ba-4d15-807c-1079131b08c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2200","original_object":"UniProtKB:P37288"}
{"id":"8a85c5ed-1ad7-43b4-8eea-4f3b0651b727","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:2901","sources":[{"id":"urn:uuid:ce64fa05-68da-49f7-bb1c-e94e6e9b51cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4075","original_object":"UniProtKB:Q16478"}
{"id":"124ecdab-31f9-4f7d-a3a4-0ef7ed521f82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567102","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:83fc0115-ae62-45c2-b0e3-b0d088e8d224","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12661","original_object":"UniProtKB:O14965"}
{"id":"74ed581b-c8b8-4246-bcdd-14c8cb507b70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611884","predicate":"biolink:affects","object":"NCBIGene:23135","sources":[{"id":"urn:uuid:71526d13-4396-4ed0-9b6e-a75c1d16ee53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9960","original_object":"UniProtKB:O15054"}
{"id":"643ee4e1-836c-47f9-a517-0b24296ed98d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JKP2Z098S2","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:dbd939f0-fbc3-42d5-aae6-56844fa68c33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12724","original_object":"UniProtKB:Q08499"}
{"id":"ab1bcdd6-f812-4a23-926d-b6b8796e847b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2252724U5N","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:d29b6cfa-9cd2-46ec-8a89-6382c5d53706","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7647","original_object":"UniProtKB:Q15303"}
{"id":"758d6e29-dc54-49aa-8435-80e0c8dd031b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27834","predicate":"biolink:affects","object":"NCBIGene:100","sources":[{"id":"urn:uuid:c53f12cd-84e5-462f-a7b1-d85a444869f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4805","original_object":"UniProtKB:P00813"}
{"id":"bc24ccc0-691c-47cc-b2f5-6b4a6d6a45d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9810140","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:60aa35f2-807e-46b2-b5bd-84d3e1942004","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2205","original_object":"UniProtKB:P37288"}
{"id":"c2c68552-fd86-432c-8e3f-8b070b16786a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:24784","sources":[{"id":"urn:uuid:d561a3f0-3019-443c-a7d1-6f8a1b2c0bd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2421","original_object":"UniProtKB:P26433"}
{"id":"c1420ff5-18dd-4980-b602-dde8cd52424c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90706","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:ff901af8-e66a-4df8-b2bc-412577ee2e4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2642","original_object":"UniProtKB:P10276"}
{"id":"a41a79a9-97d6-4644-bcfb-a0593e099c32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44292270","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:2965a4f2-7cd8-43c7-ad24-87278861bfd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1271","original_object":"UniProtKB:Q9H3N8"}
{"id":"2e9049da-9667-4b5e-88cc-1d67f55a680d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70698427","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:a1ffb82f-92a7-48ff-b272-e5bfeb2f7568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7864","original_object":"UniProtKB:Q05397"}
{"id":"692c7cf9-9172-4782-b67c-f053d43a0a06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167638","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:a022a5d4-466c-4fca-8bbc-77061546e591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7207","original_object":"UniProtKB:P35348"}
{"id":"de3e04c7-15e0-45ae-883d-f222f33205a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WTB7K8ZCW6","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:e9cf7f53-767e-4398-8d94-467bb4ab4c32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3463","original_object":"UniProtKB:P13945"}
{"id":"5d79fc6d-e5ac-45b6-9b4d-7f19149f52b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92360","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:b2c8f6ac-b0bf-401f-b5b8-87d6a93fa48b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:165","original_object":"UniProtKB:P28335"}
{"id":"6ae2e10e-ea90-4ee8-a972-08ffe27cc897","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13152","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:cfed3e59-f3a3-4d69-a5d2-4e70b94451ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13152","original_object":"UniProtKB:P35368"}
{"id":"fc07a3e7-c162-4b25-ac33-e4d8e09af1a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:02a62528-1965-4937-9c6d-61e9795864cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P21917"}
{"id":"71dd9206-c579-4a7f-960b-e6e14ca2e7c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9882793","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:0fc47e67-6098-4ec7-9800-d1cdadf3db78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:719","original_object":"UniProtKB:P41180"}
{"id":"2ed5dfa3-d7cd-4568-ae4b-3c4f1340ca8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:d36833ff-2776-4447-9270-a338836d4ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P30557"}
{"id":"573f5862-25c5-4efd-a5b3-4a6d37e2ddeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:90453152-54fd-444a-9a48-55b2cdffb5c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P43116"}
{"id":"bd6fda9c-08bf-4969-b718-9dbd065e6152","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G2AE2VE07O","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:49174b5b-42c3-4149-8463-5913f2366b72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10129","original_object":"UniProtKB:P08912"}
{"id":"2d838fe9-54cb-49dd-bebd-64163a350843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393285","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:26cd6980-4b40-46ac-b217-a432c9c03e53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10351","original_object":"UniProtKB:P29274"}
{"id":"3cc0d99f-5222-4a2d-86df-d46d4059e700","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:436c2558-df3f-4ee1-ac7c-130ca7cc8df9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P32745"}
{"id":"92e92209-a4d7-4fc8-bb34-b9d95ec293d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2065","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:ac0ab34a-0964-483f-804c-a5926f6c695b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2065","original_object":"UniProtKB:P30680"}
{"id":"b251ebd7-c70c-4381-b572-53a8c9a7509c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2618","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:55f9d803-593c-4c94-97eb-8091b4fc8e4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2618","original_object":"UniProtKB:P15389"}
{"id":"8fada267-c278-4ba4-9289-944105d490d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67271","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:4074d546-441c-422b-9d99-003dff22f1d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7945","original_object":"UniProtKB:P31751"}
{"id":"125b057f-707b-400a-8c61-a0f168be5c17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53027","predicate":"biolink:affects","object":"NCBIGene:16995","sources":[{"id":"urn:uuid:19ae2d8a-e0bd-4d0e-ac23-9f734d26ee8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3413","original_object":"UniProtKB:O88855"}
{"id":"3e9f982c-f6c5-4a6b-8e66-a4b2212bd553","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6523","predicate":"biolink:affects","object":"NCBIGene:2692","sources":[{"id":"urn:uuid:c6e54f47-a916-4a1a-bb99-0a2fe00547fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6523","original_object":"UniProtKB:Q02643"}
{"id":"367ce8c1-2cd8-4732-ac18-e14cdaac47ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:97A09L5JCK","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:5332db5d-ad45-4693-b411-6ff9f214fa70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10601","original_object":"UniProtKB:P78527"}
{"id":"6ecb8b34-d01b-4668-bce7-5d6abfc9bbf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817488","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:18829705-0881-4764-b00c-c9e81ca37322","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6165","original_object":"UniProtKB:P28336"}
{"id":"ed4e0d23-3424-4060-8867-75a3e8f36679","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:8c5f439f-5d67-4ffa-8a08-dcc273111aba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:Q13258"}
{"id":"3d4d019e-3ba0-4da1-92d1-3ec0cd8be727","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2537","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:ff6942da-3d9c-421f-b91c-0968c6a292ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2537","original_object":"UniProtKB:Q02294"}
{"id":"02a73388-d6d1-4c82-be8d-d8c8a88c0409","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:444843","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:95398e68-643e-428c-9663-0744dd628b11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1438","original_object":"UniProtKB:Q14831"}
{"id":"7e3af1de-e9f2-4bae-b3fc-b847bc647ca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FD2SWT2SDI","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:87a0cd80-6f7f-49e7-ac84-fa8fa3137354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6045","original_object":"UniProtKB:P24941"}
{"id":"55d6f91e-c839-4e88-b729-12858b698c18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2S27T3DSZ3","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:e237cd66-4625-434f-953f-ac1299241fbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8377","original_object":"UniProtKB:O76074"}
{"id":"296008e0-be27-415f-a979-6b4884203da4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90227","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:a78c3a55-10ff-45ea-91bc-5fe5b0c8065d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5665","original_object":"UniProtKB:Q02750"}
{"id":"9d1441fc-8a07-41f2-aece-bbd97b6dc016","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172845","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:911d4eec-5525-4f44-95a9-80acb1bea11c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1026","original_object":"UniProtKB:P56373"}
{"id":"8c698727-577a-42a3-b4cd-06038b53a3c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9854861","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:eabe590d-e957-4f09-bcf6-3f1162f0bd22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3797","original_object":"UniProtKB:Q9Y5X5"}
{"id":"7567be16-5235-47b1-9752-eb28398b43f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92321","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:07128767-0006-441f-a7ea-54cdc786ffc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3927","original_object":"UniProtKB:P30939"}
{"id":"e6e8bcfb-3e9e-4b0f-97b2-1bf7fa02ed2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194387","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:b712383f-02a5-4183-828f-19c433cf9786","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1393","original_object":"UniProtKB:Q14416"}
{"id":"03658fee-954e-45a6-b20e-1cc45de0c90d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73356","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:e8c8f094-3d83-4aff-be8e-1a595a5ac973","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1608","original_object":"UniProtKB:P32300"}
{"id":"c0e63d57-1c41-408d-a307-e79d1e36469b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:a11ddb33-6b33-4f2e-89bc-8671c8438f3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P35368"}
{"id":"13b9446c-357c-499e-98b9-4e8e315c34e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:5505e9e2-3a75-4db5-adfa-b174e6377d24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P28221"}
{"id":"3b1e479f-396e-4f5b-a9aa-55c38eeb68ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:000c1ca2-a563-4f8a-a59b-570e527a97ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P35346"}
{"id":"1e6b7ffd-f361-4b57-b79e-bf022ae7f9a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:b92891dc-370d-42d6-9a8b-4f2dd201de38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P08172"}
{"id":"9f5438c5-cb2c-489e-bb9f-b94dab10e7cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:8b6d760b-330f-45f8-aec1-d1a19179f56f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:P61793"}
{"id":"8e2b5635-2fa4-4e9e-88f7-deef231fd3e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11824289","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:bddedeb7-bea0-42dc-bcb5-8656c7f61b2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4094","original_object":"UniProtKB:P34903"}
{"id":"ad47a314-e90b-46d6-a072-0b399a0b1e9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10745164","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:922ea774-cf7c-4610-8c79-e0b450879786","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5767","original_object":"UniProtKB:P29371"}
{"id":"a062d8a3-f083-45c3-ab81-e0a25fac4801","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3B512HJD65","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:555708d0-98a4-4800-875d-bb46cf025af1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10426","original_object":"UniProtKB:Q00534"}
{"id":"294ea7c8-a639-4a06-9503-1055b5a3e9b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9981404","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:81acd2a8-b67c-41fa-a976-393021ab1e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4037","original_object":"UniProtKB:O43614"}
{"id":"3bd36e7e-a1f7-4bc9-87d1-49c422aba484","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4B8REJ8ZGY","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:357770ea-ecda-4be9-a5ce-47d0725133d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10061","original_object":"UniProtKB:P35414"}
{"id":"d4cfc1c3-c5f7-4cd1-ba47-671ba0e49346","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:e90e17ad-935b-431f-b142-3516edf5d70d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P28223"}
{"id":"69ebc829-51ac-40a6-ad93-9f688a9470d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437074","predicate":"biolink:affects","object":"NCBIGene:21390","sources":[{"id":"urn:uuid:5c1a7d83-a1b1-4a00-b53e-985bdc45852c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1980","original_object":"UniProtKB:P30987"}
{"id":"008a7a5c-f6df-422f-a2f3-a9b879f24818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176744","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:43d046c0-108c-4128-aa98-a0a9008e0031","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1925","original_object":"UniProtKB:P30557"}
{"id":"cd383023-4427-4c6a-a076-e9a00fc87dbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86582964","predicate":"biolink:affects","object":"NCBIGene:22848","sources":[{"id":"urn:uuid:44b0a14a-48be-42e7-ac05-c1a0bff2f90a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11688","original_object":"UniProtKB:Q2M2I8"}
{"id":"1d383b4c-d289-408e-99cb-f3adcbc93362","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177647","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:41cdd8ca-3eb5-4fd1-a2e5-57dd90467ff0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5604","original_object":"UniProtKB:P30543"}
{"id":"94808e15-c4fb-4363-a232-e3213ecc71bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:276720","sources":[{"id":"urn:uuid:586e31bc-6c9a-415d-81c0-0feaf225049a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:O70596"}
{"id":"30a6ae3f-86dd-432f-b558-ffc2f8ee7b48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140524","predicate":"biolink:affects","object":"NCBIGene:66026","sources":[{"id":"urn:uuid:d7ab3654-92e1-4330-a0ac-6fdd3dd8073b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4205","original_object":"UniProtKB:Q9ERZ8"}
{"id":"2756673b-611a-4845-9ec4-0204a386020f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:2045","sources":[{"id":"urn:uuid:297108b6-7571-472c-a202-81e1b5692528","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:Q15375"}
{"id":"8232e121-e0e5-4d45-ba8c-3f09f060352a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71682837","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:73117a1e-9a1f-4c60-b5f1-ba3bb53c0672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12119","original_object":"UniProtKB:P42336"}
{"id":"7839527f-0203-4be0-b97d-b24fc47283ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167667","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:5e8a3631-98bf-4316-98b5-8ee2cd2793ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:481","original_object":"UniProtKB:P35348"}
{"id":"82f2590f-336f-4d76-8380-82291fe86e39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9985526","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:80e13827-ed79-4064-838f-0a37eeeb3879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:293","original_object":"UniProtKB:P20309"}
{"id":"9afe6b77-c50e-4a9a-ad1e-3c2d1a32f698","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CCP2U6LWTP","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:ababff08-9942-43b1-a3a6-fcc9e5324a83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9135","original_object":"UniProtKB:P41586"}
{"id":"59452a69-020e-498a-abab-627cce3dc6a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A9C8MNF7CA","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:3aef5bbe-6f6d-4395-a3f8-2b9a64e61858","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6700","original_object":"UniProtKB:Q92731"}
{"id":"ce1a9cac-19f4-4c44-a96f-ffb6578895fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46911385","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:8ac41b2c-6940-4d16-a1d8-787501049ccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6437","original_object":"UniProtKB:P31424"}
{"id":"4c74e770-03ea-461e-b32c-eb5eac808730","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9981404","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:3fad3470-0091-49cb-9db0-5ef1fc35a789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4037","original_object":"UniProtKB:O43613"}
{"id":"66e23d00-efea-4f8d-a3cc-5c15b8d62928","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0I579CNG0I","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:b3464e15-702f-4c4a-90f3-82e935031fd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2308","original_object":"UniProtKB:Q12791"}
{"id":"7376fab6-2829-4207-82ab-efea0a416330","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70707","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:601424d9-6481-4be4-8256-2e79264d90da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7427","original_object":"UniProtKB:P14416"}
{"id":"5b5751c4-cc4f-4570-90c8-4e6ddfb81074","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5541","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:2e9ebeda-7592-484c-9203-d86ce76b0032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5541","original_object":"UniProtKB:Q9HBX8"}
{"id":"af26820c-92a6-4696-bc5a-fab5c4468a0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12546","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:acbf9d37-768e-409a-8ded-d0bb1321416a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12546","original_object":"UniProtKB:Q8NER1"}
{"id":"740f6a16-1ac1-43c8-819a-57cee326b0f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108105","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:6a14ec37-43d1-4d62-8bc9-da39128beb59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3080","original_object":"UniProtKB:Q02769"}
{"id":"73794bb5-a62b-4b65-9b0e-f7830e5b3b54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44445","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:cbbfb737-4ef8-46c9-a5d8-74c5872a40bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7401","original_object":"UniProtKB:P23219"}
{"id":"3ccea3a4-b422-4473-baa8-04156decbdec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4469","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:1bde1293-098a-4934-9bf8-99e47afd2f9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2147","original_object":"UniProtKB:Q923Y9"}
{"id":"611857d2-74a3-4434-aa58-e79f5bc4daab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49791","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:8300ebdb-b027-4590-bd51-9b3134bdf955","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5699","original_object":"UniProtKB:P00519"}
{"id":"5d672cb4-0c5b-4eab-9ce5-d3998927670d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8KC1PQ31A","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:e13e036d-6a11-4264-8bbe-433864e82d96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1397","original_object":"UniProtKB:P31421"}
{"id":"5ee3e105-5ac9-4f0c-97e2-2ae4a0643ccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29807","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:770ca485-cb40-4a45-baa9-39c29154ecce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4688","original_object":"UniProtKB:Q9NPD5"}
{"id":"fb995161-6fc9-4228-a178-b0594853c761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56639570","predicate":"biolink:affects","object":"NCBIGene:23028","sources":[{"id":"urn:uuid:670853b1-6a9c-46cc-848c-ac8c5f1df030","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7023","original_object":"UniProtKB:O60341"}
{"id":"1633c6ea-68cd-4c03-bc59-481456096db1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:a8fe69c7-9b9d-4fa5-9164-b5f3142d4f5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P07949"}
{"id":"80282bb4-32ae-4929-b919-459068d82a25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136678","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:8b6a5799-4162-4e75-8356-e4d9d5d3a4da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8899","original_object":"UniProtKB:Q92731"}
{"id":"8042e119-87c2-41f3-b66f-1240024471bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34990","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:ee16134f-bda5-4d11-9346-7ff41d8724c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2336","original_object":"UniProtKB:O15554"}
{"id":"3111d51f-6177-438b-9dd8-2a8bfe29cee4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164593978","predicate":"biolink:affects","object":"NCBIGene:440275","sources":[{"id":"urn:uuid:23425fce-d192-4c82-9d53-33b10327ed6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13340","original_object":"UniProtKB:Q9P2K8"}
{"id":"f1293a03-31af-46e0-ac76-4a7a23a80c15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:fababf9e-09f1-443e-a5a3-aa06688bc38e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q9BY41"}
{"id":"385948cb-855a-4874-801e-e70381c6866f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:40d6de8a-2cf9-47f0-9e2b-6423332035c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P25100"}
{"id":"9281af51-1b6f-42f0-9657-8e1a7ae2a7fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162396309","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:609fcae8-2c93-443f-bc6d-9ef160bd7fd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12958","original_object":"UniProtKB:P0C6U8"}
{"id":"6737c285-9013-4744-a836-9ada1350805e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2835211","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:8d4cee5d-ea2a-4866-809d-e7eef649932c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9670","original_object":"UniProtKB:P05164"}
{"id":"ca1bfdb7-97f4-4403-b67a-3c8cd85c47b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72317","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:65994294-c3d6-4bd8-b35c-8105869cc050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5887","original_object":"UniProtKB:P35968"}
{"id":"5301a9ce-7077-460d-8fc7-30f066ba2bf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:237657","predicate":"biolink:affects","object":"NCBIGene:6511","sources":[{"id":"urn:uuid:8105519b-624c-497a-8ed6-4497c7aedf1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4573","original_object":"UniProtKB:P48664"}
{"id":"04ec4365-1d6c-4b59-adaf-8a8dc23584f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6456","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:1a285403-2754-4931-b960-4c889b08649b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2623","original_object":"UniProtKB:Q14524"}
{"id":"9f848bfc-0060-4f19-8388-fe3b37194ce1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68181876","predicate":"biolink:affects","object":"UniProtKB:Q9NQU5","sources":[{"id":"urn:uuid:41f5bc91-ec1b-4b0d-a198-0ce424151898","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8941","original_object":"UniProtKB:Q9NQU5"}
{"id":"3106665e-2370-4666-956b-40cc558d4125","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:78d9a34a-cab2-4ed9-b80d-48ce6457cb4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P28647"}
{"id":"b2b9c380-38bc-4ce5-85de-e30c83c156d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71461150","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:c45c3682-cb87-47a9-9d4d-ca90c05bd900","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8154","original_object":"UniProtKB:P48730"}
{"id":"42a0b04c-0dcf-419a-97b1-5c51cf43420f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3459","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:a269797b-7742-420c-8001-88535da197a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3459","original_object":"UniProtKB:P03372"}
{"id":"518d0c58-a7f2-4ee5-99ea-19ca4fddfe91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11761","predicate":"biolink:affects","object":"NCBIGene:1441","sources":[{"id":"urn:uuid:096d5e15-8bc2-40a4-9b33-f6b6aedbf373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11761","original_object":"UniProtKB:Q99062"}
{"id":"32590a34-8b47-42a3-ac6f-9ba99b146aa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:e8d8e985-8491-482e-b171-5b8bf9be41f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P34969"}
{"id":"2ec5c8ff-72d7-4a98-adb8-92564d09c488","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137628658","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:da06fe67-b547-47b7-a85d-befd56d58f22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10532","original_object":"UniProtKB:P11802"}
{"id":"f180ba96-5373-42bc-a33e-4e2318c674f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46866079","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:09a8da6a-02c0-4acf-b556-51c5a5cbb793","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3133","original_object":"UniProtKB:Q02769"}
{"id":"b180784f-dfff-40bb-bfa4-c99268dd38b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75045","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:3a250b45-0c12-4d2f-8f23-98a5ffb0fb24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6494","original_object":"UniProtKB:P15056"}
{"id":"d52589ae-44c9-4063-ac46-02749e262ec6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11995575","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:5df2e497-7d87-474b-a282-9966f6c1d618","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2156","original_object":"UniProtKB:Q9UKP6"}
{"id":"754c05f8-9313-441b-9a13-b917c781883e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71655266","predicate":"biolink:affects","object":"NCBIGene:2191","sources":[{"id":"urn:uuid:512b9120-2b9e-4ea7-85df-07246f12d4c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8563","original_object":"UniProtKB:Q12884"}
{"id":"6e542c6d-c515-41ce-919e-7aa5c22d6e09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V70CKN90GA","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:15f4cf3e-d68a-4016-befb-cf3adc09a953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6507","original_object":"UniProtKB:P08473"}
{"id":"0288bb21-436d-408d-a873-47a9851c19aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11951384","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:7a0cb2cb-ee89-4d42-bc62-fc3502fe005f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6064","original_object":"UniProtKB:Q8NFJ6"}
{"id":"4072d7e8-c64f-4725-9e61-e16ead5c5651","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57339564","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:8122b049-a0e8-4518-bf52-950e04f66823","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1516","original_object":"UniProtKB:Q15761"}
{"id":"15980522-d93b-4ac1-b42b-b468c9404765","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195559","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:2bc78e63-a149-409f-8a89-247636eabb20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7903","original_object":"UniProtKB:Q15303"}
{"id":"fd6ac32d-7389-4d23-a8f4-62b4fb025a2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6925","predicate":"biolink:affects","object":"NCBIGene:5515","sources":[{"id":"urn:uuid:2f85fc58-92c1-48f6-a6ee-25d57f2572d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4735","original_object":"UniProtKB:P67775"}
{"id":"d013a930-58b4-449c-b35e-2f7f442ffa21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68379135","predicate":"biolink:affects","object":"NCBIGene:2828","sources":[{"id":"urn:uuid:ff3967f2-beca-4f9e-8946-76bd92238810","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10206","original_object":"UniProtKB:P46093"}
{"id":"3ca64a17-40a0-4546-9828-4c6f264a5cef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:50801","sources":[{"id":"urn:uuid:b31801cf-1d14-4681-b4d4-e51979f380b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:Q9NYG8"}
{"id":"b5825d82-9a89-4aab-bac9-f05aac1c5467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345400","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:67127183-8ac1-4749-9368-ff135e9f440d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7527","original_object":"UniProtKB:O60885"}
{"id":"42895f32-4dd7-42f5-a7f2-6cd669328b58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66524380","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:dd3dfc58-1b4b-4c6d-aea0-b43085aa9e51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5695","original_object":"UniProtKB:P09619"}
{"id":"e2e74956-297a-4fc1-a790-8969a20dac00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166177189","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:c448467d-40f0-49f6-b2d5-2c0a86d8ce16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12518","original_object":"UniProtKB:Q08499"}
{"id":"a3ed0bf4-4e7d-40f0-9030-0fb7dc631081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311291","predicate":"biolink:affects","object":"NCBIGene:25570","sources":[{"id":"urn:uuid:df356f34-3848-4fb8-b59a-0d6575f2153d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2141","original_object":"UniProtKB:Q01717"}
{"id":"694e295d-b15f-4df1-ba24-ff0325e6ebcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4695397","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:3243834b-60ee-489f-aa35-5262ab6e6c4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4284","original_object":"UniProtKB:P13569"}
{"id":"a780e034-49a9-486e-81f0-1209ada6452e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439149","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:f6feeb02-58fd-43b8-b2b1-88e19a2dd0ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2973","original_object":"UniProtKB:P51639"}
{"id":"55523646-a8aa-459d-a5f3-32e00d3efb11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92180","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:21c41ade-fd98-4325-ab03-44349f807e3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5620","original_object":"UniProtKB:P0DMS8"}
{"id":"e8627bc5-1aee-4974-85bd-5df46b6b8fb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RN3X97C29H","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:c5983b63-460a-42ec-8a52-b0ab7d402de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:783","original_object":"UniProtKB:P51681"}
{"id":"d92ff803-7822-402a-a226-40538677674e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LBRZUYSHU","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:fd31747f-ce85-4732-8a3f-337876e85a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9869","original_object":"UniProtKB:Q06187"}
{"id":"13fd10fa-6d83-418e-b47e-45fa79904b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9848748","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:24f0621f-6184-4b69-91cd-6e6f02f78e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3110","original_object":"UniProtKB:P37268"}
{"id":"33d05780-b276-41b5-b56b-6e744868ba0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130169","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:311f831d-a21d-4806-812f-16b426ac111a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:331","original_object":"UniProtKB:P08172"}
{"id":"88d925aa-6578-4065-bc7e-69088ed53a4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3500","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:dd6e56b6-8594-4928-a65a-7dfb78f63609","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:335","original_object":"UniProtKB:P08173"}
{"id":"9e156edb-26b9-4fc1-af81-380111b663ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15940","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:1dd37eda-2d99-4d80-b45e-08051505d09d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1588","original_object":"UniProtKB:P49019"}
{"id":"d20c7746-884a-42ce-8db7-6288915f6c14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90683","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:27a4b27e-f494-4626-b0ea-1213e980a289","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7817","original_object":"UniProtKB:Q15759"}
{"id":"7651d3a6-2244-45ae-af34-3e6c9782c701","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:29713","sources":[{"id":"urn:uuid:2e1ce009-6479-4f85-ba44-6536f85a2803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:P48548"}
{"id":"bf48bf1a-dea6-46e0-bd78-e992f09076e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T4W68CAT3P","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:51b12cc4-2fa5-403b-8f07-743ab74f0f40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5690","original_object":"UniProtKB:P10721"}
{"id":"92ed8fcf-5ec2-433b-a2db-41f5d5ab649f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900913","predicate":"biolink:affects","object":"NCBIGene:22848","sources":[{"id":"urn:uuid:c0245157-cce7-4214-8f90-6171900d4beb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11895","original_object":"UniProtKB:Q2M2I8"}
{"id":"2b869e2e-107a-41d1-a491-a6a75f9f5189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2611","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:f4cea776-94ca-4611-9572-61da22c62604","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7111","original_object":"UniProtKB:P34903"}
{"id":"af56e20b-6979-4212-b586-6b0a837a7557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11641563","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:ff215f77-0901-4dd0-a488-6ff363d87fdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7823","original_object":"UniProtKB:P08253"}
{"id":"c818b6fc-5da3-414c-8a34-1e0817d96b52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2100","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:7b68dc3f-8e42-482a-a160-55aba5bffd6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2100","original_object":"UniProtKB:P25103"}
{"id":"e23c5416-0cb4-4bcc-8fe9-23070266d72b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317992","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:58554e1b-6a05-4ba6-9f03-72a0abb33a0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3248","original_object":"UniProtKB:P28566"}
{"id":"1e6de78b-a76e-4371-b749-2fe0307cca1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7567","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:329ed821-3e80-4ad9-8a89-5714be2cec87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7567","original_object":"UniProtKB:P04775"}
{"id":"53b86d14-dc67-484b-b747-a0892732605e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177849","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:fdcef0ee-082d-4719-acaa-fc2b4e223b29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10408","original_object":"UniProtKB:P33032"}
{"id":"024bd508-7c31-44e8-b3c3-1ce0ba0540be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:606c8b0f-4923-453d-ad45-82a468c1cfb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P10721"}
{"id":"18019ca9-ed25-426e-aa3b-04d943142644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6792","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:494af17f-1512-45d2-a8ee-b331a8452dbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7250","original_object":"UniProtKB:P07550"}
{"id":"e7b91f47-db21-444a-9942-7ac17e656d8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232342","predicate":"biolink:affects","object":"NCBIGene:768","sources":[{"id":"urn:uuid:3ebf8a3d-9a21-4fdc-842a-79b0dcaf8d0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10149","original_object":"UniProtKB:Q16790"}
{"id":"ea3f32bf-ecbe-4bd6-97b1-8b215f24faff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119081688","predicate":"biolink:affects","object":"NCBIGene:4842","sources":[{"id":"urn:uuid:fce88a66-88c9-42a3-9167-de0a7b384e21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9147","original_object":"UniProtKB:P29475"}
{"id":"92b1494f-c587-496d-aae6-67c157f6674a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28499","predicate":"biolink:affects","object":"NCBIGene:1553","sources":[{"id":"urn:uuid:ae23a8de-bf9c-4bbe-95e1-ea836a410220","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11052","original_object":"UniProtKB:Q16696"}
{"id":"9374c043-00cb-4ea9-8fc1-85c320beefa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17941505","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:8dee46c1-b672-4a6e-9dda-fc5e0d701328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11096","original_object":"UniProtKB:Q16539"}
{"id":"3a67c0b6-0ee0-4b9a-9aa1-6243a5830937","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138424","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:a55f824a-ed1f-4097-8889-bbbf274287e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2508","original_object":"UniProtKB:Q9UHC3"}
{"id":"cf48e0ad-0d3c-4119-a084-d37b7689554f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83406","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:b089e3c9-2bc8-4128-a09d-acc34bafb007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7512","original_object":"UniProtKB:O60885"}
{"id":"d87343a6-ac95-46d5-80da-a902a0cfc221","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2609","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:a2595716-ed5c-4dea-9aa3-6bb179ee5e6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2609","original_object":"UniProtKB:Q12809"}
{"id":"79d59044-ce94-46aa-b213-6e98e0e7aa2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1020637","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:75d9840b-24ac-4f1e-89b2-2ffdb819cfe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9888","original_object":"UniProtKB:P37231"}
{"id":"3ce375b2-0e90-4750-954d-2b5608a32c64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:327b775d-adc5-4c13-b3f0-e03bbb9dfac1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P32745"}
{"id":"fb74fc4a-6db7-4cd6-9811-5f33e09f63a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11758","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:e7bb89b6-6f4b-468b-94ec-0c057181a705","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11758","original_object":"UniProtKB:P21589"}
{"id":"b1cf69fb-361c-484e-98ad-18ecda20e71b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91467","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:65911de8-6979-4932-8a93-9b45afc44ad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9912","original_object":"UniProtKB:Q15303"}
{"id":"038a9be1-8162-48fc-b04b-287dbe1f3005","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:391960","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:33889c7b-f54e-4294-b53b-259dc69bf15d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:321","original_object":"UniProtKB:P08173"}
{"id":"c87123c2-e5dc-4a2f-b7fc-d21f49561b34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:8cb90266-e93a-4423-8e14-c40c12c35844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:710","original_object":"UniProtKB:P48050"}
{"id":"6c6dd176-69cf-4a59-830c-78f6612f28db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11795","predicate":"biolink:affects","object":"NCBIGene:23586","sources":[{"id":"urn:uuid:cb72061c-ece5-4b9f-991d-3f33214ecb24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11795","original_object":"UniProtKB:O95786"}
{"id":"e5696238-c2ea-431f-b85c-1af7c5b2ec2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230501","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:190cc6ed-4804-405a-8dcd-9effb63fdc78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7491","original_object":"UniProtKB:Q8WUI4"}
{"id":"cbdfb107-6e9f-4b26-bcad-a5fb4b5d8147","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9908595","predicate":"biolink:affects","object":"NCBIGene:498475","sources":[{"id":"urn:uuid:6df1eb29-43f4-4e3f-8740-d6cd281cf939","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1879","original_object":"UniProtKB:Q9R261"}
{"id":"c2589452-f5b4-4a19-af98-99f2a6d56741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:f1e1de60-ab9d-4389-b1dc-39ac38fa2516","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P41231"}
{"id":"409d49e8-07ad-4766-a2ca-629d419a6acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:8c489f89-2d70-4ea3-9441-c6044c630c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:P97288"}
{"id":"c50816b5-d7ca-4204-b39a-42cf91e559a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23725177","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:5a14f95b-692b-47c7-bd62-abe1171463a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11598","original_object":"UniProtKB:P41597"}
{"id":"1ac95f39-85fb-47ff-adef-245e956c8ce1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:906532e7-45f8-4caa-b09d-10aae5877d35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30874"}
{"id":"dc1099bc-9962-4d8b-8516-39cda12ffd89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:12480411","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:2e6b3773-f6c9-4ec8-9278-caefb9932c57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6270","original_object":"UniProtKB:Q8BLA8"}
{"id":"c092d54a-93f6-420d-9145-4e7420a17f1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:33JD57L6RW","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:4434eebf-45b6-4d0d-89b5-1f2418f6c08f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3508","original_object":"UniProtKB:P25101"}
{"id":"ed086111-ffc4-4862-a576-14ef3e7437b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9165","predicate":"biolink:affects","object":"NCBIGene:3000","sources":[{"id":"urn:uuid:9fb387dd-9ade-48d4-8a6d-684bd64baf4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9165","original_object":"UniProtKB:Q02846"}
{"id":"cc1bd1f9-9cad-4e0c-95d1-f07f88659feb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2630","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:bbd289b9-bcd0-448b-9e2d-d601aba37627","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2630","original_object":"UniProtKB:P35499"}
{"id":"8c1b2daf-60a2-4b45-8615-55a52636d735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2056","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:d2f2b965-686b-40ff-85e4-8182adaaf449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2056","original_object":"UniProtKB:P30874"}
{"id":"34669466-c5a8-4cf8-b058-ef593da17c1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10198719","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:9bcd2608-7216-4902-9972-e3cd8c2cf104","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9270","original_object":"UniProtKB:Q9NR97"}
{"id":"40ac1343-b94b-4570-b462-b3883e450190","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76850154","predicate":"biolink:affects","object":"NCBIGene:24412","sources":[{"id":"urn:uuid:1ff8e168-5cc0-48a8-8471-3099876b38a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7845","original_object":"UniProtKB:Q62645"}
{"id":"b77c4f19-a330-4056-95ec-eba637279ef5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9887077","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:cee6cb39-b273-42ba-a0d5-b63e94dd9541","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8868","original_object":"UniProtKB:P41145"}
{"id":"24537a6a-e53f-4053-8767-d0e0c2c6ac7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13671155","predicate":"biolink:affects","object":"NCBIGene:25413","sources":[{"id":"urn:uuid:1315e189-7487-4faf-8a34-4a86c43a6ad6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12977","original_object":"UniProtKB:P18886"}
{"id":"d43bb7a2-80a5-4e47-ad74-45fdf7678b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44222958","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:293080fc-ed49-43d5-94ca-eb67a733f4eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8214","original_object":"UniProtKB:P36888"}
{"id":"f7d1aeeb-8256-4d56-b91f-d946b4d494eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:12750","sources":[{"id":"urn:uuid:4430137f-c8cc-4dd1-95fa-79ea33e11c9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:O35493"}
{"id":"5a74ebe2-c788-43fe-bed9-c981645e2bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:c53ac5d2-fbc5-4044-ac34-618f513d200a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4193","original_object":"UniProtKB:P47869"}
{"id":"f3d91f3f-e3a3-4046-9e9d-f9891a607871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:0faafae9-0378-4af5-9ba2-631998219331","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P20309"}
{"id":"1803def7-c062-47a2-8c2a-5320f5bc8a89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:6b67702a-fcf1-4944-abe3-a5986c36b03f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P07333"}
{"id":"6877e727-501a-47d5-a1ef-610e308a1151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8460","predicate":"biolink:affects","object":"NCBIGene:940","sources":[{"id":"urn:uuid:75b200f0-6661-419c-bfbd-0c4053790d24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8460","original_object":"UniProtKB:P10747"}
{"id":"12f02955-09ca-4e8c-8e00-18d09c6254d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17659","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:29c80340-d975-4662-8662-dbdc29a15310","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1749","original_object":"UniProtKB:P97794"}
{"id":"0171e747-7d0b-4f77-948a-c1eeb98f416d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56846820","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:b16a3abb-ef0b-4482-8897-ab3d09bac7e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7855","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"b2d3926a-b729-47b4-b3b3-1ec5e795e528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233362","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:2d96f495-6b6a-4352-8241-4093d4ac7068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7382","original_object":"UniProtKB:P11802"}
{"id":"304c3ecc-1273-45db-be66-c94fae0c86cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132178569","predicate":"biolink:affects","object":"NCBIGene:8408","sources":[{"id":"urn:uuid:c7bff43f-d9a4-4ade-bdc0-cf96801d18a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11340","original_object":"UniProtKB:O75385"}
{"id":"c92bd4c7-f700-4af4-abc2-8cdce2adc387","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:beb3d6f6-6104-45b9-b8c3-d02b30b90043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:342","original_object":"UniProtKB:P08173"}
{"id":"517f3d71-b113-42d4-bd62-f75dac57d47d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125340","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:c8daebac-6537-43a1-9359-9f7bef6cce6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8061","original_object":"UniProtKB:Q96GD4"}
{"id":"9e250552-c2f0-452b-8ace-7fac550dae6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16796","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:33710a31-8268-4ba2-abe9-865bdb4ffcae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:224","original_object":"UniProtKB:P41595"}
{"id":"8327a209-2bf3-4c76-8061-bace1621737b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232811","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:f686ce37-16f7-4ce7-bf5d-2fccac52b97a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12074","original_object":"UniProtKB:P06493"}
{"id":"6ae65f38-43b4-444d-af9b-9948ac17ccd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17303","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:97af6e5b-815c-489a-a016-bda774a60a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1627","original_object":"UniProtKB:P41145"}
{"id":"a58a3861-f7f4-4bce-8b5f-4952a4c90326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9887077","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:078b3bee-4524-44d6-9671-b3ca46ee4b30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8868","original_object":"UniProtKB:P41146"}
{"id":"16beb389-aab6-41f6-b142-55f65b9ea3d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KF50235Q04","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:dab401f0-2ed4-4e9c-b3f6-08c931bb3762","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7346","original_object":"UniProtKB:Q9Y5N1"}
{"id":"f0097aa7-40ee-43ca-8f8b-9c049118578f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32111","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:3273e805-91d4-4ae1-bee4-72ded4835b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5432","original_object":"UniProtKB:P59537"}
{"id":"dc99f51f-598c-433c-b54e-6de73d4aa7e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:394N1Z644H","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:c949b72c-42da-4fda-9973-d9e3e241e5c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5111","original_object":"UniProtKB:P35228"}
{"id":"6f0ddd34-49f4-4562-8939-384783e4688f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:64CW205BDD","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:45df5f93-88a2-4441-b9ac-57507ce56b9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9800","original_object":"UniProtKB:P42338"}
{"id":"6d1fa798-8218-4a73-9101-c11dd335999f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17639","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:75e197a2-b4e9-4cce-961b-0e4967c9b12b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2766","original_object":"UniProtKB:O75469"}
{"id":"9c40008a-8061-46a2-bc80-1f47a741fd34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71967","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:0b5717fc-5f67-4864-9823-af7cfc134927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7951","original_object":"UniProtKB:P42336"}
{"id":"29b70a14-f721-4501-975f-0d087986ba1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15393","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:28191c9d-9607-438d-a3b2-5d260628d811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6413","original_object":"UniProtKB:Q8K424"}
{"id":"d203cc16-1bbb-43c3-9924-0f34e5b91da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:7eeefd3c-f1e3-4346-9baa-937f552295e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:Q15077"}
{"id":"9183ea1e-ec08-4ca6-bc4c-e60cd66c315f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:aa1f2ce3-011b-4e0f-8c5d-b38b9acd7ead","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P35408"}
{"id":"0a5290af-db09-4ee4-b337-0fa234deba51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11567371","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:f00c4ddd-cd89-4296-95a8-ddd6980b35aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5723","original_object":"UniProtKB:Q8TDV5"}
{"id":"332d02e2-65ac-4d3d-a518-2bc367a34b25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:2b413c8b-9c1f-4d09-993a-139ca9a9124a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P28335"}
{"id":"e5a7b61b-675d-4965-b17f-ca888290325d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34756","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:c73c2d2e-af55-440e-8eb6-2a5e0c2c4d9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4182","original_object":"UniProtKB:P51788"}
{"id":"66b32798-99ca-4452-85e2-4b0e81c5e593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9810632","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:2d57206c-1f00-4e19-966d-073640ce0db6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2241","original_object":"UniProtKB:P30559"}
{"id":"a1e8b46b-e0fa-43f6-95de-2f1147e9f5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4740","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:0b6f36d7-132d-4a0e-adee-a0ca62f00d1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:345","original_object":"UniProtKB:P11229"}
{"id":"30116e31-489b-4fc4-9743-7e81ae14a0f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5001","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:9c270e50-b245-4186-a9ad-fa75657cf214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7186","original_object":"UniProtKB:Q07869"}
{"id":"bee3f238-2a3e-417c-81f3-ada6f047d968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755026","predicate":"biolink:affects","object":"NCBIGene:20608","sources":[{"id":"urn:uuid:678d75de-75a5-41d4-8a51-545ab37d1929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2078","original_object":"UniProtKB:P49660"}
{"id":"6164e71e-8a9d-48a2-9ad6-7698655361d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44450050","predicate":"biolink:affects","object":"NCBIGene:7174","sources":[{"id":"urn:uuid:fdef9c30-7a25-4412-8f34-c7d9b400659b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8582","original_object":"UniProtKB:P29144"}
{"id":"64878477-939f-449f-9025-685328117e94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:12c79a38-c6d8-4322-adbf-92eb5d510427","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P50406"}
{"id":"a2c73456-51e4-43fc-a69a-f37a20e184fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136019","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:2331231f-2b02-4a3d-bd57-e93591dafb2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1651","original_object":"UniProtKB:P41145"}
{"id":"270da2a2-fe46-4176-a9ed-3650d00af828","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817480","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:c688da10-b576-41e8-bc40-9527102091f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6091","original_object":"UniProtKB:O43603"}
{"id":"92af8e65-19a1-4dc4-ab90-a9814e7bdad9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3216","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:8022f5d7-bc0e-4778-a408-d6f4a85572ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1670","original_object":"UniProtKB:P41145"}
{"id":"61981350-5a32-474e-9566-3d009b1afcbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:641H0Q518W","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:8faa9bfc-4752-4562-80fa-0fa50bdbb053","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13017","original_object":"UniProtKB:Q9Y572"}
{"id":"6b3329bd-48a7-4055-b5c1-e04b0c5c9c36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LJA4M1L5LG","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:68b173e3-e2c8-4507-9552-c03bc2584e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5595","original_object":"UniProtKB:P29275"}
{"id":"e7f7e537-6eb7-414a-a4f2-f9d3f1999d11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2084","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:04485933-61f2-4c3a-a3f3-65c5fcb9b5af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2084","original_object":"UniProtKB:P35346"}
{"id":"b5501954-b0a2-4b7d-a095-ca1badf9478d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2186","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:f16ad36c-7293-40fd-b600-a79a1e585c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2186","original_object":"UniProtKB:Q00788"}
{"id":"06567a4f-fd35-4b2e-b391-ee045e10b423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177470","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:e6a18057-e805-4091-82e9-cc8ba8dc5701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1894","original_object":"UniProtKB:P21731"}
{"id":"2f29ed7c-41c7-4938-8d4e-688d54a80c66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18388","predicate":"biolink:affects","object":"NCBIGene:1545","sources":[{"id":"urn:uuid:e94ad8b6-ec37-4f6d-964b-30ec05e5e9ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4136","original_object":"UniProtKB:Q16678"}
{"id":"e2af631e-3388-49ef-9135-4d2d1860ff75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91370","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:ad782fb1-0492-4afc-93db-da28e4cf173d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9381","original_object":"UniProtKB:P36888"}
{"id":"1c1ee0b9-8347-4f05-bfaa-a3f510e19d64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3287898","predicate":"biolink:affects","object":"NCBIGene:8694","sources":[{"id":"urn:uuid:1584dc09-34d7-4a1d-8a30-228c758681a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7832","original_object":"UniProtKB:O75907"}
{"id":"67e34862-3891-4c99-a18e-8dcf5a6a5ca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7034","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:28010d34-1839-40d7-8f7a-a998355c1d79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3996","original_object":"UniProtKB:Q9GZZ6"}
{"id":"f53911f8-a48e-4668-bb45-252077d8e044","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:ec9f6fa4-dcdf-4408-afea-d8dff1a5ef18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P21917"}
{"id":"eaeef59f-929a-4403-853a-b5c9b4de9d44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755180","predicate":"biolink:affects","object":"NCBIGene:260319","sources":[{"id":"urn:uuid:79bda290-0747-44b7-91e6-9c92ec43e622","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6176","original_object":"UniProtKB:Q8K418"}
{"id":"8768c107-3b12-41c9-bc48-03c65cecdce1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:3f41263b-858f-4ab3-9d83-7e81e74a74b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P11229"}
{"id":"e4d7dc37-aedb-4e1a-9c30-1ae2f8062779","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45II35329V","predicate":"biolink:affects","object":"NCBIGene:79400","sources":[{"id":"urn:uuid:837f1e83-a491-4011-aa9a-caa2f0d8916c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9932","original_object":"UniProtKB:Q96PH1"}
{"id":"0b5c1ae2-aceb-4b10-9f94-aa7daca5d605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93645","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:122c86e9-5472-42d0-94ed-df9b02bd4d71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3304","original_object":"UniProtKB:P21918"}
{"id":"2365f2af-8bc9-4a5e-9ca3-36e7b1e278c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1QMD83K4YN","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:e3503569-49c1-430b-ba39-841158db2617","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11448","original_object":"UniProtKB:O43614"}
{"id":"163e2f4c-bc91-42b0-b0a3-9a4a1314dd35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817390","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:252cb1c6-d090-4397-a589-34ed20110b67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1129","original_object":"UniProtKB:P43219"}
{"id":"22258206-ce9e-4337-bb69-94467bb2be87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71967","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:567a691f-16ad-4011-bca7-b592d548c93d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7951","original_object":"UniProtKB:P42338"}
{"id":"5bf7a4e5-4569-4874-b333-28df5d03628e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231413","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:3bb7f2e3-b847-47d6-b3f7-5b282290f43e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11540","original_object":"UniProtKB:Q13526"}
{"id":"29737a58-a943-4231-a89b-c07e27a519d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47924","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:4d4eb96e-021d-45f7-8ee9-ad0750e74c00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7914","original_object":"UniProtKB:P98170"}
{"id":"66ec0cbc-80a5-46f2-bc88-986ada1a8eab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13162","predicate":"biolink:affects","object":"NCBIGene:25083","sources":[{"id":"urn:uuid:ee877ed0-3425-4c4d-b36e-2d3dd7349e56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13162","original_object":"UniProtKB:P22909"}
{"id":"ddea2c8b-ee88-4205-8344-0d23469cfee1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9604","predicate":"biolink:affects","object":"NCBIGene:3575","sources":[{"id":"urn:uuid:df6edf35-25a2-45da-8ea0-da2c7f923eac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9604","original_object":"UniProtKB:P16871"}
{"id":"5d89fc76-efdd-40c2-b559-5894ea4bcdb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17950211","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:d3625e0e-39af-4ee2-b12d-13068c827909","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1388","original_object":"UniProtKB:P23385"}
{"id":"70f07862-ffd4-41ff-86eb-cf66c0007eaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8205","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:a55a84c1-471b-4a91-8dc8-14c1a4f51904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4286","original_object":"UniProtKB:O75311"}
{"id":"ccf6c0f8-ebb4-444a-ab56-42bffc394e43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:46BBW2U5D6","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:cfe64e73-7de4-4eee-9874-be3caebaf228","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11656","original_object":"UniProtKB:P09960"}
{"id":"3696b8db-4190-4950-81ce-79cbe46a46e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9807249","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:6f826e6f-1322-44d0-84bb-c9f49f9f5c5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2198","original_object":"UniProtKB:P37288"}
{"id":"0565e330-ee0c-41eb-bf97-1ceef2f4934c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131174","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:a38a8de5-0aec-4b11-a09f-b11ef6d93e1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8319","original_object":"UniProtKB:Q07817"}
{"id":"4f657806-6ab1-4bf1-9e27-405ec94a8ce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13692","predicate":"biolink:affects","object":"NCBIGene:958","sources":[{"id":"urn:uuid:179d5872-e92c-41a3-80b8-b2e07a26992f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"antibody_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13692","original_object":"UniProtKB:P25942"}
{"id":"fd171003-6f0e-4ee8-903d-32cf23529da4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35255","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:c7f1a528-1134-4ea5-b97c-201ac6c37d6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2503","original_object":"UniProtKB:Q9HCF6"}
{"id":"8210b692-07a0-4428-84e1-8e74b6f92bc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438353","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:ade1c729-5e34-49bc-b3d4-bf4a2d300ab3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1634","original_object":"UniProtKB:P41143"}
{"id":"dd51ed92-7ca6-4d03-86c9-e4aae977b5d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90241673","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:a008ab59-6c16-426c-b1a9-3d5a94b3cefb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8287","original_object":"UniProtKB:O14744"}
{"id":"134afe83-ff8d-41e6-9b19-89b414704030","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U2H19X4WBV","predicate":"biolink:affects","object":"NCBIGene:9263","sources":[{"id":"urn:uuid:3f61f958-7f0c-4228-a5e1-70ad9b1699c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10167","original_object":"UniProtKB:Q9UEE5"}
{"id":"70b55d29-c29a-49f6-8af6-5873b33a591e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Z3QHB00LB","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:834f087c-419a-4f27-99c9-0a38a8fd351c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8383","original_object":"UniProtKB:P48736"}
{"id":"0646732a-d673-41f8-85ae-3555f0c4b519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2066","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:3b5aae8c-e5a6-4dd2-9cb5-dfb5d7d0b36d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2066","original_object":"UniProtKB:P35346"}
{"id":"8eb701d1-b590-4809-a3a9-a25deed3da17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310996","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:30f98f05-8ad5-456b-a0dc-240c65236cc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1755","original_object":"UniProtKB:P47900"}
{"id":"c2496b93-dddd-4df7-bcc8-7fb181534567","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16078986","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:b44b54a4-13bb-4c4c-9f14-e4a3b8439b3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1753","original_object":"UniProtKB:Q15077"}
{"id":"2b1c4a8e-d74c-43a0-a96e-8be917a8f195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:62151","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:f06c95f6-75bf-4978-8f8d-29a42c481d1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2466","original_object":"UniProtKB:Q8R4D5"}
{"id":"3b5660d0-128f-401c-a79a-acf90de12fc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827339","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:903dcd19-7c80-4683-af8c-6a6f1446c344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:369","original_object":"UniProtKB:P0DMS8"}
{"id":"84b4ab48-3f6a-4388-af1e-262b533f0044","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73287","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:83c92884-63df-4bfc-bc99-4581c25d714c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:526","original_object":"UniProtKB:P08913"}
{"id":"3011fb92-22c8-49a8-b26f-0201bebc2cb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92715","predicate":"biolink:affects","object":"NCBIGene:7052","sources":[{"id":"urn:uuid:08f312f7-faa7-42d6-b03b-6e3149bdcd54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5994","original_object":"UniProtKB:P21980"}
{"id":"fec06f86-0b48-43ba-ac46-ed2a7c8db5f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67116280","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:6ab70422-1368-4a1f-b165-b74d9f8cf014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9308","original_object":"UniProtKB:P56719"}
{"id":"97a012cf-bd9c-4ba5-bcdd-02e923c95320","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1113","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:0ef43bb2-242d-492e-835f-4ea1518f4e82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1113","original_object":"UniProtKB:Q02644"}
{"id":"2ec19d06-99bb-42f7-89ba-41da4e5fa1cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93259","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:2c1bec83-354f-44c2-9df4-3af1af487709","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1050","original_object":"UniProtKB:Q5NUL3"}
{"id":"c2f6f0cd-f9ff-4246-8a69-ecd9e9f9ba74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9NPC24K8FA","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:43fbf965-b1f8-472b-bde0-cfe2733de61c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6054","original_object":"UniProtKB:P35968"}
{"id":"c41cc5c6-a5fc-4f3d-a8eb-fc52af7b8830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136189563","predicate":"biolink:affects","object":"NCBIGene:25865","sources":[{"id":"urn:uuid:20e1ffd2-6c94-4605-b70d-0ffb50149185","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8048","original_object":"UniProtKB:Q9BZL6"}
{"id":"f771b305-4ff9-4047-854f-dd10084955d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755087","predicate":"biolink:affects","object":"NCBIGene:3709","sources":[{"id":"urn:uuid:90c0e20e-334c-43ef-9c78-38e56e1ec2ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4223","original_object":"UniProtKB:Q14571"}
{"id":"ca6e87b5-e049-4136-b5b4-0be4c4e5462f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2198","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:1b820ed1-dcca-43a2-b706-0f2e57e5b366","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1347","original_object":"UniProtKB:P49286"}
{"id":"aa17a84e-231c-4686-861e-1461051e0366","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125484","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:7b62a56f-eec3-4ef2-a05b-2ad492b9f9ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9233","original_object":"UniProtKB:P34972"}
{"id":"90ea9e75-87dd-4c4f-8629-a3c88e219db3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755160","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:3d4dc0ad-7f37-47f7-83b2-0c06088a4e5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5825","original_object":"UniProtKB:P21462"}
{"id":"71bd0b43-bab7-45f2-9484-ef45c163455e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4806","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:77ea4900-ed71-418f-9339-5c8e9a291abd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7002","original_object":"UniProtKB:Q92831"}
{"id":"59ec25ca-bab2-42d2-a1ac-e75ae7611334","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168476124","predicate":"biolink:affects","object":"NCBIGene:7486","sources":[{"id":"urn:uuid:481deef0-5f95-4977-b41f-b2313b733d30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13020","original_object":"UniProtKB:Q14191"}
{"id":"c0eaa9fe-633e-4a3a-b369-6e23afc49847","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:1dc22555-06b8-400d-9ef0-00d119843f2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:Q14432"}
{"id":"f2a30894-6d78-4a88-a219-3f25df2963b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15713","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:3f9e1294-b147-4e9c-a81f-04b1295b3512","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1734","original_object":"UniProtKB:P41231"}
{"id":"a5f54444-74a8-4666-bdcf-64405298aa8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2171","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:d0bc42d2-df9e-4e11-8b38-6a6bd496100f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2171","original_object":"UniProtKB:P37288"}
{"id":"0e8f0dc1-e861-4cba-a059-48c4d7743cbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233643","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:8b682a57-9638-484d-b8ce-b205d7273049","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7017","original_object":"UniProtKB:Q96KQ7"}
{"id":"e81739f9-0873-4098-bc35-765b54c46b3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6102","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:e53c1280-8e5b-4c01-b23a-512105a5a86d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:650","original_object":"UniProtKB:P30411"}
{"id":"81817409-997e-44ef-a1d2-203445c0b0e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L4C1UY2NYH","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:f27884d5-5f47-43ab-b3b6-54406e24dd34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9636","original_object":"UniProtKB:P42338"}
{"id":"7fb4f5da-5680-4eaa-ab1e-5e437b44784a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:8124491d-56f0-4fa7-a0c0-3859c22d7b8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P41595"}
{"id":"780ea793-ebe7-4969-9970-6bee6f65cda1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK43YC00I7","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:48c38a3d-9697-436e-a0ab-79834fdfd0eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:183","original_object":"UniProtKB:P28223"}
{"id":"d713df4a-770a-48ae-bcd5-2fa16cd858fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:cd8b8f6c-06bd-4ecc-aa2f-a97fa5799984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P18825"}
{"id":"7e334f09-288d-49e8-9968-0af5580a9223","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4806","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:1c920cff-cd69-49e6-bf96-b752ace4443c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7002","original_object":"UniProtKB:Q13627"}
{"id":"b85093db-6592-4531-8972-c89b249ceaf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91938092","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:24b47339-f253-4591-89bf-8ea93ce1f187","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8773","original_object":"UniProtKB:Q6DWJ6"}
{"id":"622fbdb9-fd30-4d65-815a-dc5811e01845","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817417","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:d6190f8d-e0f8-4aab-9654-cb8d506f9e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1508","original_object":"UniProtKB:P21555"}
{"id":"a342aa8a-e240-4c6d-8929-665b6a524f73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93432","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:78c2c0d9-afc9-49ad-9e81-5b8176a5f598","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8584","original_object":"UniProtKB:P20309"}
{"id":"ecba5cde-7f0b-4384-b7c9-64ac34f9a2f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57339564","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:9cb5aafb-5149-40f5-aa01-0682f8c617f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1516","original_object":"UniProtKB:P49146"}
{"id":"056c4477-5dfb-4f99-acd7-e387c81b0522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FB39E94UXK","predicate":"biolink:affects","object":"NCBIGene:57406","sources":[{"id":"urn:uuid:dca6df57-1749-4157-9d4e-e15dafcd134e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10062","original_object":"UniProtKB:Q9BV23"}
{"id":"50d20563-3aa5-4a56-805c-a9bdb5db8ab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CR743OME9E","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:0d2e5bec-0a28-4bc0-b52f-cb148fe9eb18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7838","original_object":"UniProtKB:Q16539"}
{"id":"23f5b9eb-9425-4a80-adfd-ea7cdf0fe59e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494480","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:00d98fc7-58b8-4344-a6d2-1ad633765706","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13050","original_object":"UniProtKB:P32249"}
{"id":"87e70316-a634-40a6-942e-4c5548a6757a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:84500","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:c0fbe011-5703-4399-bcdf-fa1710464443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5459","original_object":"UniProtKB:P43681"}
{"id":"c4c89326-dd80-435d-8d70-c51b8649fcd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2091","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:60c82d78-46c1-444f-bddb-619ada4bcfc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2091","original_object":"UniProtKB:P25103"}
{"id":"c38f3a90-eb07-4e56-be64-5d85e0259d68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AM9K4SZ3XK","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:4b84f907-78af-46a5-a33a-0d8438f33284","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12122","original_object":"UniProtKB:Q15759"}
{"id":"4c54f67e-b7c6-4a43-bda0-cbb5c47737cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92950","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:619799f5-c746-4bf4-8ae7-7094fa2a3c20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:515","original_object":"UniProtKB:P35348"}
{"id":"c323fbee-4dca-42f9-a66a-2003aaaf222c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17200","predicate":"biolink:affects","object":"NCBIGene:140795","sources":[{"id":"urn:uuid:d019ddc9-9426-4899-a62e-db4af7f739af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1784","original_object":"UniProtKB:Q9ESG6"}
{"id":"aa283ee1-3574-4590-9f27-89e56f8a2947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49603","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:32dc17e6-f1e8-4ab5-bea1-da4125ee463c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5692","original_object":"UniProtKB:P00533"}
{"id":"f37d534c-c253-413d-8ac2-813668312604","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93781","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:5a323f63-c2e0-46bd-89f9-27bd24164b00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6030","original_object":"UniProtKB:P24941"}
{"id":"f5d88bb6-a2f1-4e9f-aa62-5915d23f39f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162651518","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:c2d7b8d7-458f-4d0a-8668-61501223b419","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11826","original_object":"UniProtKB:Q99572"}
{"id":"e0345206-d63b-414c-a0e6-35196c00a3ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66919","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:294eec11-bfa5-45d5-ad9b-9b9a4da482bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5688","original_object":"UniProtKB:P29597"}
{"id":"f06a7d4d-b7c6-417b-b4aa-76b89c3c359f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232500","predicate":"biolink:affects","object":"NCBIGene:24230","sources":[{"id":"urn:uuid:79d2bf59-7a53-4347-87be-4f1118d53c20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8704","original_object":"UniProtKB:P16257"}
{"id":"47deefd4-5ef3-4974-a0e7-c82ef8d0d003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RA72G28VE9","predicate":"biolink:affects","object":"NCBIGene:10287","sources":[{"id":"urn:uuid:015c1c54-20bd-41bf-adfe-8a3659be956d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7784","original_object":"UniProtKB:P49795"}
{"id":"f5a9c738-21bc-450a-ae40-98c316926c45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9M363811V","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:15a5e428-9d07-42bd-a2ce-57b20a095443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8104","original_object":"UniProtKB:P22455"}
{"id":"567412f2-499b-4d72-9b6d-65afa482057d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5282428","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:385327d0-652d-421e-b1e4-cba227af1491","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1967","original_object":"UniProtKB:P35408"}
{"id":"427806b2-7c18-40e1-9251-27366b4372d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119517","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:65d284d6-df40-4895-962f-6dde4a8f3b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2225","original_object":"UniProtKB:P47901"}
{"id":"8cda210e-d536-41f3-90e2-af8b6375b9db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:157175","predicate":"biolink:affects","object":"NCBIGene:526","sources":[{"id":"urn:uuid:2d244b53-971a-4891-9526-4877b52b404e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8882","original_object":"UniProtKB:P21281"}
{"id":"57309284-72bb-4684-ac7c-cd93dc04f73f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSZ0E9DGOJ","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:832f427f-b454-4e2f-a3e4-48ad893dc281","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4146","original_object":"UniProtKB:P31644"}
{"id":"1dab75ee-c411-4b56-8efb-04d6d2e1a27d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311453","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:2536cb85-df51-47b7-8391-135ed513fc1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1939","original_object":"UniProtKB:P21731"}
{"id":"745ef591-437a-4562-935a-4ce5a4287dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:759","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:5248ae08-2824-49c4-8359-2a6fa8a25233","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:759","original_object":"UniProtKB:P41597"}
{"id":"f388f281-e625-4b2d-9855-50fae403d02e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73356","predicate":"biolink:affects","object":"NCBIGene:53919","sources":[{"id":"urn:uuid:e37dcc42-c0c4-4309-a9ac-acd40c3fb7ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1608","original_object":"UniProtKB:Q9NYB5"}
{"id":"24959192-01b2-4c2b-86dc-42e252b41fc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5523","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:0e3f95ad-5867-446d-b61f-a7679cbf40ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3879","original_object":"UniProtKB:P30968"}
{"id":"8281069f-4b4c-4f90-ab4b-731c6ac73377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56658139","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:097bde47-2561-45b8-bf39-282800d2d0d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8551","original_object":"UniProtKB:Q6V1X1"}
{"id":"f995b72f-f5b9-4159-b191-6ce140cab081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123984","predicate":"biolink:affects","object":"NCBIGene:610","sources":[{"id":"urn:uuid:c4b71c7e-7dbb-4d1e-a0f8-48b53efa7fa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2359","original_object":"UniProtKB:Q9UL51"}
{"id":"674d185a-a0ed-4c6f-8438-7353102fe9a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136218973","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:cd7693b0-1099-43ab-aaf7-db8779005d24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5590","original_object":"UniProtKB:P30542"}
{"id":"5c2008b6-9e94-4dea-b614-9c2a86726735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:56827","sources":[{"id":"urn:uuid:4d0c2a9b-09bd-485c-95a0-5bc0a69b2b8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q9Z0Y8"}
{"id":"e9b4f5d7-89e1-4f89-841c-fc98953dd194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91556","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:f474c884-9312-4658-a85e-aa70bb11b7fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:161","original_object":"UniProtKB:P41595"}
{"id":"bddf4edd-af07-45e7-8268-87ff88ab05f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:895","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:adb8df39-b6a6-49cf-8560-930b62dd15ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:895","original_object":"UniProtKB:P30553"}
{"id":"b3b4bbf6-dfd4-4184-b68e-a66e9f5a63d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813891","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:9b47f503-4f96-4152-b528-18268eaf0db5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6122","original_object":"UniProtKB:O43603"}
{"id":"d0681aea-49de-4eab-8fa7-77ac82486706","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25125014","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:e958738b-8276-4d80-a7e7-e9b211963892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8176","original_object":"UniProtKB:P50613"}
{"id":"28c86d1a-b66c-4384-b05f-da44ac032a41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2955","predicate":"biolink:affects","object":"NCBIGene:50832","sources":[{"id":"urn:uuid:52da40c3-4202-45ea-9f14-7a7b41d77309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6510","original_object":"UniProtKB:Q9NYW5"}
{"id":"feebebcc-f598-4f1b-a341-734787f9886d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41774","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:bd22c1e4-36eb-442b-851a-d38fe57f10b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1016","original_object":"UniProtKB:Q92731"}
{"id":"c9adf9e7-4a7a-4ae1-9ec7-a39b435db823","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:920","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:3de55aa9-25c2-4fea-8859-64e7c29adcfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:920","original_object":"UniProtKB:P34998"}
{"id":"d38aebfb-5426-47d5-9526-a9912ce85d92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92593","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:5d19d230-0566-4143-8696-ebbcc4a21353","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4346","original_object":"UniProtKB:P14867"}
{"id":"37fbcda6-25ad-4413-a80c-90df6910ad8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VFC23V742Z","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:12a636b8-b66f-4b9c-b853-6a1e32a947e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1619","original_object":"UniProtKB:P35372"}
{"id":"c405cf21-2fee-4f2b-a9f3-e555ae34b4ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92857","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:226007fa-544e-42b5-b9ce-be6c77093ca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5937","original_object":"UniProtKB:P05771"}
{"id":"5012aa28-cc8b-499f-aec3-a187be5247af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:fa253fa3-550d-4e4d-928b-b26629dd78bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P35367"}
{"id":"8a416381-ab9d-44eb-9488-0abef8308184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16019476","predicate":"biolink:affects","object":"NCBIGene:6563","sources":[{"id":"urn:uuid:df9153fa-b75a-42ad-8fbf-1a7496b7bc1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8881","original_object":"UniProtKB:Q13336"}
{"id":"7b23f242-3119-4caa-899e-d113db51bf85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996514","predicate":"biolink:affects","object":"NCBIGene:8111","sources":[{"id":"urn:uuid:98faf42e-fdcf-4b80-9670-a289490f3361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10571","original_object":"UniProtKB:Q15743"}
{"id":"a1635a3f-1aa3-4c4c-86ec-4b77b7f27b01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ed257400-67f3-4e5c-95a7-fedc23767c84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P28223"}
{"id":"de270c3b-81cd-4953-9f48-e6c1da0a39b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2539","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:ff12830b-4dc0-4813-ac67-f7e1f02cf97e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2539","original_object":"UniProtKB:Q02294"}
{"id":"d21597c2-ee33-408a-b5f5-4401b4c55b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1554","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:a7bce2a9-c5a6-4032-af59-60be442795f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1554","original_object":"UniProtKB:Q15761"}
{"id":"531c5c16-a7bc-4583-9b0b-3f4008d66bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:1369603b-dca5-4d79-a00d-c0304c3f5f75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:P31644"}
{"id":"c177fe9d-b14f-49c5-937f-d4fad04f06d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70789348","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:38302fa3-cfc4-42de-8476-8439560df24e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13057","original_object":"UniProtKB:P0DTC1"}
{"id":"8f61360a-61c2-47ef-b948-7a6c2fb04f6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34942","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:77e67d0e-417a-473d-885d-e15fb1f16bcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2595","original_object":"UniProtKB:P51787"}
{"id":"7c3c54ac-8d42-4ee1-8362-41b52dca601d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:186197","predicate":"biolink:affects","object":"NCBIGene:23411","sources":[{"id":"urn:uuid:24c01171-ff4b-404d-95ab-61c1b09076fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9514","original_object":"UniProtKB:Q96EB6"}
{"id":"5cb39748-a92b-425e-b771-3d31916147b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176744","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:87589ea7-71f2-4ece-9823-83ba505ffbc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1925","original_object":"UniProtKB:P35408"}
{"id":"db670791-a37a-4893-8fab-d43886f6c60a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z7YP8B158Q","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:02f4d4ed-75d4-46b4-9ac5-f0c3c6e50091","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:531","original_object":"UniProtKB:P08588"}
{"id":"6e79987d-4936-42bf-ad39-a1deb255098e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16584","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:5a97c3a5-70c5-409d-a3ce-7771e12b3858","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3048","original_object":"UniProtKB:Q8BLA8"}
{"id":"5ef3b22e-f040-458d-a21c-c2d99feacb33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T77D5438IM","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:f977bea3-2731-41fd-bcd1-a3cf173c259c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5831","original_object":"UniProtKB:P25090"}
{"id":"d93f1280-4941-4d28-9eb7-475146702d6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:cf2c4eac-0408-4ae0-987c-7fec83f77ccc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:A8MPY1"}
{"id":"2d3d902e-b9b3-4caa-8bbf-4f565fac3b97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24809764","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:3f3a8b17-5846-4022-96d7-daba1d143c46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8191","original_object":"UniProtKB:O00311"}
{"id":"5eb74543-aa08-40ad-8bac-9c03ffc3ff20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9811445","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:5a24be63-39aa-4c53-9c37-685585093986","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2321","original_object":"UniProtKB:Q92952"}
{"id":"591ecdba-dc76-4a8e-987a-d4d2d14747fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8313","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:362f7fc1-a9ee-4c21-bcbe-491b09d8cc18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8313","original_object":"UniProtKB:Q9UGN5"}
{"id":"05672ede-0430-44ca-b66e-172c694f9f5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7851","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:3d7f78c9-e937-48b8-bad2-6d34506a0208","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:302","original_object":"UniProtKB:P10980"}
{"id":"59c60724-501a-4592-a186-7637c433b555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:0b4a63cf-b831-44eb-bfc8-5f6aaad69a84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P30939"}
{"id":"7e08bb26-b26f-4e9b-9e12-66207be6c018","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:b1630ba5-dc01-4890-ab7d-2e6c4ea984e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:P42681"}
{"id":"807cc2bc-d04b-4d49-9346-07daab0bc9bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9058I8S63D","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:53a66141-083a-4d75-a3a0-6683f567c8d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8012","original_object":"UniProtKB:P78527"}
{"id":"218e6a69-723e-4f54-90e9-08c98681233d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2010","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:b912ca0f-4fac-4db3-8491-9b1a7830c62d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2010","original_object":"UniProtKB:P30872"}
{"id":"b1f3de23-6959-4f3a-b8a0-2f9447163cbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:a457b00d-c93c-464e-9bfa-919b5cea554b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P30872"}
{"id":"096b83f6-c7fa-4952-ac6e-a01e254674ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229661","predicate":"biolink:affects","object":"NCBIGene:4780","sources":[{"id":"urn:uuid:99c764f5-1bf4-4654-89ef-e89afa9001d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7573","original_object":"UniProtKB:Q16236"}
{"id":"83b74fff-96b1-40aa-96a6-7d00aceaeab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2339","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:171f412c-f600-4587-bc56-7ae430b17cbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2339","original_object":"UniProtKB:Q9Z258"}
{"id":"1b28ab70-0c8a-49ec-a05d-24c55bb527af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4049","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:cf98589b-0f39-4bfc-ac19-df328bd7d52e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4049","original_object":"UniProtKB:P55085"}
{"id":"57e4b82f-fff3-429c-86ea-dfac2be53e3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817416","predicate":"biolink:affects","object":"NCBIGene:297795","sources":[{"id":"urn:uuid:7c75ac28-1122-4c1a-a679-c1d7e729f7dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1497","original_object":"UniProtKB:Q56UD9"}
{"id":"54b2b586-b6c0-442c-b3c3-c834e7a274c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:507","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:23f0b6f7-3b3c-4e92-8b70-0e53d360e20d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:507","original_object":"UniProtKB:P35368"}
{"id":"8aa3ba96-ef71-44c6-b362-51a80439b455","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136609","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:fdb2de5a-d785-4ce0-a8e9-1ab2485083df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12464","original_object":"UniProtKB:P59534"}
{"id":"361289ea-e6d0-4d97-9ed9-5329563a7983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92215","predicate":"biolink:affects","object":"NCBIGene:347411","sources":[{"id":"urn:uuid:7302d9b9-e9fe-45a4-bfd1-2b01b32c6ba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2919","original_object":"UniProtKB:P0DKB6"}
{"id":"130bdf65-18cb-429e-a281-ded85d3a26d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:8f7ad981-d454-4e56-9813-c3f4385752c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P43116"}
{"id":"541e6ae0-2a0f-400f-b447-26b9d71cd6c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155567226","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:4738a3e9-4d8f-4803-a96f-24948438b110","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11479","original_object":"UniProtKB:Q9NR82"}
{"id":"f8ccbd4c-a32f-49e4-a87e-ef2f2df0f24b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8086","predicate":"biolink:affects","object":"NCBIGene:92","sources":[{"id":"urn:uuid:d2c5761a-f272-406e-82fc-e820c7fe747e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8086","original_object":"UniProtKB:P27037"}
{"id":"ca777ae0-e439-432c-9a8e-4072caa94665","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RR6P8L282I","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:66b7b4f3-99da-4e52-885e-5b184d845c6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9289","original_object":"UniProtKB:Q99500"}
{"id":"817289a9-6347-4ba2-b2a7-eef5bcf34550","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:478573","predicate":"biolink:affects","object":"NCBIGene:169355","sources":[{"id":"urn:uuid:ede5e503-27ce-4bbc-8e48-96b3e408fff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10126","original_object":"UniProtKB:Q6ZQW0"}
{"id":"50eb1ee3-b70d-4a1c-82c4-61fbc274fcec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134709","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:e39c232e-10b6-4bc3-b45e-f260709af848","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8924","original_object":"UniProtKB:P35367"}
{"id":"54b0f2ae-0735-4734-8a33-e3cd61aa43da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9844019","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:e0b8fa5e-2738-43c1-a052-e9dc0e9d4354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1684","original_object":"UniProtKB:P41146"}
{"id":"ac4eac86-ed2e-4772-aa4b-d6629afc489e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:929","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:8c36cdfc-60cd-4b0c-a261-97f33d212d69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:929","original_object":"UniProtKB:Q60748"}
{"id":"eeb792da-d5b3-4a4a-8df7-398cd58ca11e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183900","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:9c5f7366-74f8-4582-a051-7ccdd2eeddfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6197","original_object":"UniProtKB:Q9NS75"}
{"id":"627758b8-e232-440b-9f38-ca5c637c6213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104023","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:b1be1c6d-b390-464d-80c2-89241e108588","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3329","original_object":"UniProtKB:Q9Y271"}
{"id":"ca0582a1-2e24-440b-8c86-bfcfba0de270","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4312","predicate":"biolink:affects","object":"NCBIGene:23133","sources":[{"id":"urn:uuid:a8b343c6-fdc8-45fa-8180-9ddf29bc5fc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7025","original_object":"UniProtKB:Q9UPP1"}
{"id":"32d9e6d2-c9cc-41d3-936f-40c50f2b2170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27882","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:30d4d29a-9939-4cf1-b50e-281d9b90a9ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2367","original_object":"UniProtKB:O60885"}
{"id":"b25c106b-f6c8-4e31-8d7e-7986cfe9b9b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132316","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:27c3b89d-f50a-4df7-b146-a68f526196db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1643","original_object":"UniProtKB:P32300"}
{"id":"e2bb34a3-f88b-4266-9c5a-eab4dcefbd4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9JH486CZ13","predicate":"biolink:affects","object":"NCBIGene:112399","sources":[{"id":"urn:uuid:0846095c-91cd-4633-8c7a-14aac48fd96c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8456","original_object":"UniProtKB:Q9H6Z9"}
{"id":"1bea8680-9ca6-4342-9da3-14d9d2b3f94b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190326","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:13b27771-b5a6-4de6-8c01-6530636531f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:731","original_object":"UniProtKB:P23415"}
{"id":"b551d037-7545-4928-96bf-1beb90aac9eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156371488","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:9e5263c1-f90d-43bc-925e-e06c399ae8dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12389","original_object":"UniProtKB:Q16288"}
{"id":"960350e1-dc14-4fe9-a342-4eacddd59a07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184693","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:84706f34-bbf5-46a7-9681-8f5ed1c4875d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2292","original_object":"UniProtKB:P46098"}
{"id":"7ed45daf-1b64-48d8-a1fe-d9efd892abc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817385","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:3af30326-1b69-419d-bf36-c5e3213ce8ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:923","original_object":"UniProtKB:Q60748"}
{"id":"805a291d-9553-457c-b25a-13416dffb008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101615586","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:f73e7392-0167-4853-9e64-cb4d6b0981c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"non_competitive_antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13592","original_object":"UniProtKB:P08684"}
{"id":"4b8ad534-6714-4038-a559-d9596b617f13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183836","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:c46e86c5-0c02-4677-84b9-d1e86ac76708","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6161","original_object":"UniProtKB:Q9NPC1"}
{"id":"ed8fe277-f87f-4943-a51f-bf680840a1f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23631116","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:b569867e-774d-4020-9198-6259dd003b50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3538","original_object":"UniProtKB:Q92847"}
{"id":"3ac5fd80-ccf4-4f9b-ad55-21394467356d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85102","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:60170550-fcf1-4a73-9c90-9a6c108d4bf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:338","original_object":"UniProtKB:P08172"}
{"id":"8b975d62-9a44-4fba-b067-ef55df5fdbe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231398","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:05acdb58-9522-4bf2-bb36-648e953c46bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9121","original_object":"UniProtKB:O43614"}
{"id":"9e352884-6c84-40b4-96a5-28ac9272b1c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:39cceb0c-4d84-410e-b16f-db5400e57201","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:Q9QYN8"}
{"id":"98789bc2-e357-47e6-8a5b-f4aa9db3a599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46212971","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:95242275-ec3f-43fe-8961-e8c629c3d9e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12711","original_object":"UniProtKB:P00533"}
{"id":"ce8c050e-9ea9-4295-908f-ee266a411636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2719","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:e9f66ddb-9375-415d-b973-0067d645c5b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2504","original_object":"UniProtKB:P50052"}
{"id":"7224250e-e1e6-4ce7-8dc8-2e5bfc8a56bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6104","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:c2ff883c-668c-4409-898b-cd0870193c36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6104","original_object":"UniProtKB:O60755"}
{"id":"4bf08571-6c24-4f1f-968d-ed3fe989f101","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82813","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:033f7c8a-f554-4aed-a84e-23afb78609b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2349","original_object":"UniProtKB:Q00195"}
{"id":"ad0d6508-29c3-4e4b-958a-2faaaa372b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166140536","predicate":"biolink:affects","object":"NCBIGene:7486","sources":[{"id":"urn:uuid:aa0b0e6a-85d0-4789-9b81-1158b7f4086e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13018","original_object":"UniProtKB:Q14191"}
{"id":"c759d9d7-5049-461c-947a-110db39274ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11175501","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:4d7fb778-f376-4929-81bd-b284fc902776","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6341","original_object":"UniProtKB:Q13255"}
{"id":"07a982fc-cfab-4838-87c3-1a7180bdfe75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:682930","sources":[{"id":"urn:uuid:7bb3000b-aa40-4f1d-95c6-b854615a67bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:Q02485"}
{"id":"4b44fd11-d7e6-4724-b1f2-2ca58093f253","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42609940","predicate":"biolink:affects","object":"NCBIGene:10060","sources":[{"id":"urn:uuid:36966608-f567-41a6-88be-12c1f55a31c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8808","original_object":"UniProtKB:O60706"}
{"id":"248a0793-97bc-47c3-ba3e-0e47401cc1fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7627","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:26c54a50-51d7-4e26-ac99-015ed4fd4d8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2880","original_object":"UniProtKB:P06401"}
{"id":"bc6454be-6392-4f12-a00c-d1900a176b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3972","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:3f8ccb28-9ec7-4980-b7b1-cfd159a6d31d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3972","original_object":"UniProtKB:P02708"}
{"id":"e7a9071e-c37f-4f35-8146-18f50f98f2c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11332190","predicate":"biolink:affects","object":"NCBIGene:2825","sources":[{"id":"urn:uuid:3343474b-4411-4a80-88f0-61496eb23620","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3422","original_object":"UniProtKB:P46091"}
{"id":"c517b149-b77b-41f8-8b7f-d6303fb9aa4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41879","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:e5aedb4d-cbd5-408a-bd8f-94b30197354e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2768","original_object":"UniProtKB:P08235"}
{"id":"4c18258e-9fa3-4b1b-a6a3-aabccf00846f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95049","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:6d311371-fab4-4cc0-8dbc-5b52f5e23eab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9375","original_object":"UniProtKB:O14965"}
{"id":"4caa5adf-029b-4211-a3a3-5bd46b9327af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:4194957b-aca3-46e9-bcab-c396c9b395d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P43405"}
{"id":"423417c6-d594-4212-80b7-45f90fed3a69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3750","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:96cf978d-fc68-41a7-8ec5-b82022cc92d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2667","original_object":"UniProtKB:Q07869"}
{"id":"b782374b-76ed-47b4-b154-7716795f7e77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:349149","sources":[{"id":"urn:uuid:84eda36a-e8f9-40d8-963c-c3dbac4d6f43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q8NFK1"}
{"id":"49e34401-b902-470c-a9b8-eef6fcf2dd8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5132","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:a89b57e0-0977-4295-812b-9a9f25ccae24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6943","original_object":"UniProtKB:P10275"}
{"id":"f885daaa-d806-4193-b6e9-1afa49245114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:ddaa8381-7b4f-43ca-8876-c3dac5743692","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q92736"}
{"id":"5d5f004d-6407-45d4-a507-5dd3f04fb20b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:108643","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:735bc8bc-b31d-4ed8-8688-1ac947fb5395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9468","original_object":"UniProtKB:P41231"}
{"id":"f3a193cc-9b88-4cd8-a586-a4cc65119ebf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66919","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:9c7e0031-dc56-4005-855d-f836b2d0166e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5688","original_object":"UniProtKB:P52333"}
{"id":"41e6eb54-e87c-41ea-bd85-712d758768f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0I32BCL40Z","predicate":"biolink:affects","object":"NCBIGene:24326","sources":[{"id":"urn:uuid:5df98db3-5377-4472-822a-aeebf390bfda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3528","original_object":"UniProtKB:P26684"}
{"id":"8cb5dc54-451f-469e-8401-3f9ea0cc48d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:ebb0507c-68d9-4ba3-921a-2801f3e8cfbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P34903"}
{"id":"85c83044-835e-4cbe-a6ef-af8fd7a5adc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92386","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:81ecc5ed-e031-46d6-90fb-e1c59a6d171d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:523","original_object":"UniProtKB:P18089"}
{"id":"f47ba0c9-0238-4c47-bcd6-c90a998745d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:e4e08c07-b6f6-4e41-9b51-10d2e0bf61f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P28476"}
{"id":"2d0812e3-ce6a-46d9-b09b-68cd2c3acf8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5647","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:2804c2f0-82da-4c53-b42d-177b3fa7d29b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5647","original_object":"UniProtKB:P30874"}
{"id":"1b6122ce-9adc-496b-871b-e04bb56c8f8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:c761e2b9-a09c-4a9c-809e-0d1abb4380f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:Q92633"}
{"id":"51efebe5-d02f-4356-b15f-95941131dfe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231355","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:c14ce17c-052e-4852-ae8a-d81fb6208912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8098","original_object":"UniProtKB:P56524"}
{"id":"e1df76ca-9d45-4654-b193-8cb15a513881","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N673F6W2VH","predicate":"biolink:affects","object":"NCBIGene:1522","sources":[{"id":"urn:uuid:40a0ea16-8f6c-4d94-aaba-93b59aff3543","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6478","original_object":"UniProtKB:Q9UBR2"}
{"id":"30cf24e7-42e9-48ff-a9e0-39aaf562c894","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46192505","predicate":"biolink:affects","object":"NCBIGene:7016","sources":[{"id":"urn:uuid:fac9db57-6e09-4f64-9ff6-71651839fa2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8117","original_object":"UniProtKB:Q15569"}
{"id":"58badd40-86f6-453b-9d4e-71c7032a750b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44392476","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:7b39a479-4ea8-41ac-9502-147f358739f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2995","original_object":"UniProtKB:P04035"}
{"id":"095dafc4-41e3-4524-83d0-ac4930f99d2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U8I57RC739","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:f43d88ee-1d64-454f-b814-8fd7eeee8cfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2658","original_object":"UniProtKB:Q07869"}
{"id":"71a25559-4ef9-43cf-8a9b-b304a1419eb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76279","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:c587569d-7ce5-447b-b96e-ff6dbf3374c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6333","original_object":"UniProtKB:O94759"}
{"id":"8a1062f8-dd78-4cef-9fb0-45dfdbea0e71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134717374","predicate":"biolink:affects","object":"NCBIGene:51548","sources":[{"id":"urn:uuid:272f5ea0-e868-4e81-aab3-327d3bacc6be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:10123","original_object":"UniProtKB:Q8N6T7"}
{"id":"d9ca45db-abca-4ab2-8983-0f85246f157a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5854","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:9bfa4a27-8ab1-43f3-bcdf-854e0f5ca21e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1371","original_object":"UniProtKB:P23385"}
{"id":"a6a6e7a0-6b57-4d01-a03b-0c5b2ad1bc12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12435","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:b48d39aa-a49c-4650-8a31-7124e61a8ffa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12435","original_object":"UniProtKB:Q9NYW7"}
{"id":"29ceab29-b349-49cd-90cd-c1de6bc50afc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:444007","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:df6af3cd-09e5-4e21-9f4e-94e19a4b1dcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:870","original_object":"UniProtKB:P56481"}
{"id":"4cf00008-abf3-4d20-af4b-9c055ecf557e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9851134","predicate":"biolink:affects","object":"NCBIGene:840","sources":[{"id":"urn:uuid:2a3639f3-134a-4552-8581-5731aed9b524","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8654","original_object":"UniProtKB:P55210"}
{"id":"0288c557-08a6-4eec-80c5-53b7c8c624cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4469","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:3d13cabc-63d1-4181-820b-1218efb41e10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2147","original_object":"UniProtKB:Q96RJ0"}
{"id":"461aff9e-ad91-49ec-b713-a30551e1e1ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66720778","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:403250b9-7ce3-4733-b788-67f1d92f86fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10886","original_object":"UniProtKB:Q9UKP6"}
{"id":"62ca634b-83b9-4040-b855-e7007d050071","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15741","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:ac1c4e4d-a706-4521-bd4b-42e124f32279","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3637","original_object":"UniProtKB:Q9BXA5"}
{"id":"aaa79975-0931-4849-858a-b4dc163a24d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2003","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:1d10e03e-691c-47e4-bc82-2626a191777b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2003","original_object":"UniProtKB:P30872"}
{"id":"290b9b83-ead9-4fce-bc10-8cc04c9e7f98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58056241","predicate":"biolink:affects","object":"NCBIGene:3654","sources":[{"id":"urn:uuid:724458e2-4ece-4144-baff-9ce2bb7b0c36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8084","original_object":"UniProtKB:P51617"}
{"id":"841abdd2-3e5f-4426-9815-63170ea838ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21202952","predicate":"biolink:affects","object":"NCBIGene:24408","sources":[{"id":"urn:uuid:906e3e6c-7267-4bc7-9675-d21beee321ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4208","original_object":"UniProtKB:P35439"}
{"id":"dd53b044-a300-4fa1-95bd-5182e857aa16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:b36d9d8d-c6ee-4fcf-8a31-4fb7975e8f4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P20309"}
{"id":"aa3a29a8-e77f-4ded-9fd9-39f300737398","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996537","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:d16bb455-04dd-4860-a422-4b94b95f2be4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10650","original_object":"UniProtKB:P14618"}
{"id":"36b7c41f-b2a7-4da2-a68d-933e2da5a88c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312124","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:c1a26f5c-e016-4be6-8518-9704a9043b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:70","original_object":"UniProtKB:P08908"}
{"id":"16c5b92a-f881-4f75-a7cb-ea6c4c824526","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7478","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:e499f57a-921e-4e3a-a6c5-888f8c8f1386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:45","original_object":"UniProtKB:P28222"}
{"id":"f6176394-5098-46e3-a3cf-297444914dea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90848","predicate":"biolink:affects","object":"NCBIGene:292661","sources":[{"id":"urn:uuid:7a6f5830-0173-4d71-91bc-35b40890bf6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5852","original_object":"UniProtKB:P43253"}
{"id":"20362f71-4bfe-4c96-9888-c251a13b3914","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Y5629322X","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:6df15295-38ff-4190-83ff-53a75c2c0467","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6476","original_object":"UniProtKB:P08246"}
{"id":"73b68a1d-a1ea-427c-8023-e432d04a83e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J2WIV0JMML","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:28a2d9d8-851d-44e7-969d-811faba7483d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10652","original_object":"UniProtKB:P35372"}
{"id":"82ce0c2f-9424-46d9-9d43-26cc954fe467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A5595LHJ2L","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:b66262f8-ad1e-4454-9142-85cec3b677f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12644","original_object":"UniProtKB:Q14524"}
{"id":"1302beaa-c82a-4ee7-a8e5-35fa3f20b27e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98BSN6N516","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:0edd61b3-b9b7-4a41-9164-3cfd46555c4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9789","original_object":"UniProtKB:P11362"}
{"id":"a33ce905-2f5f-4c76-a6d9-a4f517fcf779","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9846574","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:a66dbce8-7da8-475f-9b6b-b8461ccd050b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2164","original_object":"UniProtKB:P49684"}
{"id":"50b5d3cd-0111-4331-855e-9573fb399392","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60172452","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:f5afffaa-eddc-4226-8d9d-365396454eaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10099","original_object":"UniProtKB:P00742"}
{"id":"3b38ea60-0a2e-44ad-b26c-b549852771d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92089","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:a827e87a-d5a9-421a-a198-b404367092a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6674","original_object":"UniProtKB:P35462"}
{"id":"85275340-066f-477c-82a8-516c58f094e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1480","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:ab772895-b24e-407e-a8fd-3cfb25746593","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1480","original_object":"UniProtKB:Q9Y5X5"}
{"id":"e3c20d79-c1df-45f5-9043-4593d8398f1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15343","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:ed43dceb-151a-4243-b059-7e684a43db50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6277","original_object":"UniProtKB:Q9H1D0"}
{"id":"6e3de873-06fc-440c-b5ab-4b54b571c766","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10324989","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:7384634a-55d2-4f0c-b383-6031e0b89d42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9799","original_object":"UniProtKB:P34972"}
{"id":"936f6ba6-107d-4f5a-9226-6c931c0b1132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2556","predicate":"biolink:affects","object":"NCBIGene:16491","sources":[{"id":"urn:uuid:7d0866cc-0a17-4502-9f32-28ba6ef62153","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2556","original_object":"UniProtKB:P16390"}
{"id":"194c9eac-d95e-44a8-82d1-a9d6a7fde60e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91806","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:bdb2620a-91e3-429a-bc0e-62f8234cc5b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4140","original_object":"UniProtKB:P39086"}
{"id":"cf228ab7-a1c7-4576-b821-3c4fd75ac113","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34543","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:09a42e8c-9b81-4965-b004-c01df6c43552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2168","original_object":"UniProtKB:P47901"}
{"id":"0e6ce819-951f-4324-901f-2eb65a94cf85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311227","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:9806c007-5a42-4eaa-8f59-38522ba483b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1914","original_object":"UniProtKB:P35375"}
{"id":"2dc6ed6f-bdca-43d5-b8f3-13834ee1e6b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2154","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:3378d48e-981f-4a37-a80a-59a6c1bd2e90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2154","original_object":"UniProtKB:Q9UKP6"}
{"id":"60853bd6-0699-49a6-a8d8-3d4e812d79d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53484100","predicate":"biolink:affects","object":"NCBIGene:6725","sources":[{"id":"urn:uuid:c4320006-a47e-41f4-8909-7546890d3492","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8212","original_object":"UniProtKB:Q9H3Y6"}
{"id":"757cab87-e4c0-4773-9299-d02b1c955e48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79991","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:57ec851d-c914-41ed-83ca-c76b472bada1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2686","original_object":"UniProtKB:Q03181"}
{"id":"d8d58271-6e74-4197-9e45-2067c394bd76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135962","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:d41abcb8-ccf1-4120-beea-ed21a9ac8c5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7901","original_object":"UniProtKB:P31645"}
{"id":"76479cd5-e140-4af4-9b14-74461effc28b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B57Z82EOGE","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:8dc8e7bd-f2aa-443d-bebd-bbcd9810b0a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:120","original_object":"UniProtKB:P28222"}
{"id":"33b4cd02-e0fb-487e-9ff4-14fbe70a10c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9472","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:83f6ac72-9b03-48bb-9aba-9844b20a9b52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9472","original_object":"UniProtKB:Q9GZZ6"}
{"id":"2fd67814-46f6-4a73-b21a-154795f67d11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9822RX831L","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:d9c75fa0-56b7-4793-9afc-733ddbee7081","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4000","original_object":"UniProtKB:P43681"}
{"id":"33bd710a-a335-45e2-88bb-5be5ab7f23aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115007","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:204ece57-109d-4675-8377-fa0741496bf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:955","original_object":"UniProtKB:P35462"}
{"id":"c7167320-873e-4a72-a0dd-f8486910f5bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54683103","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:b8044b8d-12b8-49ac-8ec0-f4ec51e4996e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10326","original_object":"UniProtKB:Q99835"}
{"id":"1fe3d2dc-e83c-48ec-be44-cb9c19f8a452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16137682","predicate":"biolink:affects","object":"NCBIGene:9283","sources":[{"id":"urn:uuid:4f76d5ff-df8f-47e4-9aa6-09b7235f16ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6067","original_object":"UniProtKB:O60883"}
{"id":"6611dd1c-c6f7-4153-a25d-76c94964f366","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CZP9GB25HO","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:3a1a1e58-1087-4236-b5f2-cd13abf94f46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7836","original_object":"UniProtKB:Q02750"}
{"id":"34193288-2d91-4f09-8435-0eadb22ab387","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95021","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:c7613e08-be70-4d1b-ba3f-82dad61115c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6837","original_object":"UniProtKB:P00374"}
{"id":"ef79c576-9102-44a7-84d9-895d899c6d2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69477","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:efef1505-3f89-48f3-a4cc-e2b84f4420ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11094","original_object":"UniProtKB:Q8R455"}
{"id":"68773764-ac2d-4361-86ae-eeac3d3cd8ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94038","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:2123419c-7ea7-4327-b638-52da88f7580d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:300","original_object":"UniProtKB:P11229"}
{"id":"617b1574-27d2-4250-b669-0c36b141aa21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10434","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:4753fba2-dc30-43a9-8dd0-450d1941e855","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10434","original_object":"UniProtKB:O43570"}
{"id":"6c55d964-1e3b-4ec2-8ce1-b50381d7aa08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16483569","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:566bc5e0-4499-4cae-8145-0a22cc16a3c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11559","original_object":"UniProtKB:Q9UGC6"}
{"id":"0a9c7773-d639-4218-98c4-049b4cdfe846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:e3496499-8404-496e-ae13-07ea93535805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P08908"}
{"id":"52dd562f-df19-49db-831b-c12b2abaafe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821498","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:dabec658-3c94-4071-9ace-3ad269be2a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:167","original_object":"UniProtKB:P28223"}
{"id":"c3f4cef0-ff0a-407c-a479-33b5171492d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32297","predicate":"biolink:affects","object":"NCBIGene:5136","sources":[{"id":"urn:uuid:13db6b69-5972-4bd9-aded-4c95cccc8b5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5285","original_object":"UniProtKB:P54750"}
{"id":"2bd08bad-6bd8-4151-8dd8-fa45aad70264","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:20814785","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:b822d26f-d460-4c6b-90ab-2d7cd7b95570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:660","original_object":"UniProtKB:P46663"}
{"id":"9a168850-b8dc-41be-baf4-149fd8929a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86291498","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:ff8dc70e-465b-4158-b263-c3221b496911","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12646","original_object":"UniProtKB:O15554"}
{"id":"d944b108-45ef-4402-b78e-a5a59707ce30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94305","predicate":"biolink:affects","object":"NCBIGene:4314","sources":[{"id":"urn:uuid:57c7502d-1340-4eb0-90cc-3437cb7dbe17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6528","original_object":"UniProtKB:P08254"}
{"id":"5801cc30-67f7-4171-8bb2-403f79cea2cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:e143024f-a0a7-49f1-97bc-ba174c8c6ce0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P97288"}
{"id":"21365c23-ff0c-4b6d-ab1f-de76167039dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78544","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:9ca01c50-92ca-4228-8246-986d737b01f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5976","original_object":"UniProtKB:P49841"}
{"id":"35ef1a75-9adb-4a2c-bf39-760d8d2e5b23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135348858","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:2889e673-2ba9-4833-8e7a-219956cf46ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10490","original_object":"UniProtKB:Q8WUI4"}
{"id":"b085ad68-5e6b-4d47-820f-031616241438","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2077","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:367c7c34-7515-4dfe-be64-b6c2d09c9b7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2077","original_object":"UniProtKB:P32745"}
{"id":"6e7813f7-7333-4482-a5a4-40f3bde57e17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:4052bcbb-dbcc-4a95-a795-e2e5438817b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P21728"}
{"id":"109f0e0e-e4e7-4f81-946d-89eeb5bf9f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:8868e690-ce4c-4c9c-9480-bef624710429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4156","original_object":"UniProtKB:Q16445"}
{"id":"a857e272-7e3d-445d-bdf9-bb0cefae9080","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O9H5KY11SV","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:caa5c8c6-207a-4c6b-ac96-4704efbe6bdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10883","original_object":"UniProtKB:P43235"}
{"id":"cf7e6752-4a7a-4b33-83da-94fc48761504","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:944ced87-08bb-4850-aa8c-cb5d61656283","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:O14965"}
{"id":"a95718d7-5ee7-49d6-b587-f4b48468dde4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:a83bf1fa-1310-492a-9756-6acf3dd2efa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:P14780"}
{"id":"78d8fb60-f96e-43c3-9295-2bf3fa266bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17263","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:3f9bdde3-f36c-43bd-aee0-c0a79530056c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2818","original_object":"UniProtKB:P03372"}
{"id":"e2f99626-dd89-4e2a-af41-dd826656bc6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63937","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:6d2bb0a8-f288-4107-896c-358955041844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:486","original_object":"UniProtKB:P35368"}
{"id":"cf2b0d4c-2b41-4362-818d-ce21da51cfc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79560","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:53e9c509-c88d-4606-a6b6-ff7e9f6c284f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4210","original_object":"UniProtKB:P42261"}
{"id":"5e558dc3-fc13-4991-8921-39996f3803d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188525","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:46bf82f4-d83e-4715-8075-95246126d12e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:46","original_object":"UniProtKB:P28221"}
{"id":"ddaf07c5-9662-453f-bb9c-4e3b8bf301a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29807","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:8cf2850e-ab94-42b4-85f8-813210396c82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4688","original_object":"UniProtKB:Q9Y6L6"}
{"id":"759f3bb3-79da-4c14-92b3-af09e44ddc29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78432","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:ef1172d6-62c3-47ad-95e7-92a4473bd817","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7397","original_object":"UniProtKB:Q9UM73"}
{"id":"35480d5d-57d6-4d22-9e1a-792a9c8a06f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8251","predicate":"biolink:affects","object":"NCBIGene:1048","sources":[{"id":"urn:uuid:43510a7c-9a9f-4307-bf9d-3825065da72f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8251","original_object":"UniProtKB:P06731"}
{"id":"4f494c3e-a2f5-4dc8-b617-bd34959377c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13908","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:7fca1721-b083-432b-91a3-1cb1d80dccdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13908","original_object":"UniProtKB:P08581"}
{"id":"1f6a94de-4a74-4ded-a117-3be475f9e798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:b22be354-a9b9-472c-9317-e1cca50e2ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q13304"}
{"id":"3406eae5-010b-4481-98e2-4891f8996d1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9853822","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:805747d6-8947-442f-b80b-b148753effbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3525","original_object":"UniProtKB:P25116"}
{"id":"2daf0650-804d-4133-b903-6f3d28d03c8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230501","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:ee67fc83-7dbe-413a-998e-22656bf5b396","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7491","original_object":"UniProtKB:P56524"}
{"id":"a472b017-7795-4f90-b6a9-7ea87e2494d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28834","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:7758da38-90df-401a-b287-7a1a8f5099d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:610","original_object":"UniProtKB:P21462"}
{"id":"0bdf03dd-244c-4819-995d-f91dc57c54a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134457640","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:4925f02c-8a8c-4cf1-b8ba-bf3c24acba06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11114","original_object":"UniProtKB:Q13164"}
{"id":"737ee443-f6de-40ac-bcb0-e90d7463c65b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10839674","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:0169b674-8c61-425d-b9e3-51233b827b73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9530","original_object":"UniProtKB:P30542"}
{"id":"7edd78b1-6d81-481f-8626-8b170c32f156","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142183","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:11da798b-4b7e-471e-82a6-0018e8f566f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:166","original_object":"UniProtKB:P41595"}
{"id":"e62293fa-abc6-4b07-9e14-abf6f8de7c6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R2N8IH71HC","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:3c167b0d-7b36-439a-a230-70a2e9b1b807","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3334","original_object":"UniProtKB:Q9NS75"}
{"id":"e76d41dd-2f07-4043-82c3-5d05804f01e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:b4fc05b3-abfb-4719-8f3a-5f5267af26c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:316","original_object":"UniProtKB:P20309"}
{"id":"098d7e95-2e38-40f0-b69a-ca612190f395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10002","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:b7a83499-60f0-4bdd-94f7-2878815c8dc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:433","original_object":"UniProtKB:P29274"}
{"id":"bb5df930-8a76-44b4-8f69-c662b4718957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:9be714d5-b238-41b4-9a97-81f37aef8b7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:Q13255"}
{"id":"d1c8d8db-2d2d-4b50-8dc8-c1e61a78f8ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4708","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:11a28606-1d7b-4b6a-aee4-d91d9d530d3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7170","original_object":"UniProtKB:P25100"}
{"id":"a1a0f59f-0512-41ce-be34-7ef3c42f2b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:dd8dd7ab-9d71-450c-9bb8-8eac06e9bcc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5385","original_object":"UniProtKB:P25100"}
{"id":"a42c4a26-b25b-4053-8090-8c7af72088e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3V7GQ1260K","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:5aa36fd2-829a-4a81-bd83-b5a6a97ec67b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9697","original_object":"UniProtKB:P52333"}
{"id":"6f68213a-2eb7-453a-ad31-a7f15de70588","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231350","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:f42a6670-89ea-43a2-9ef8-722c3cf0a638","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7793","original_object":"UniProtKB:O60674"}
{"id":"abe2cb33-cde5-4ee7-9542-3c7badb11891","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:8911","sources":[{"id":"urn:uuid:ce23fd6d-1541-4f6b-b707-c92d90837534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q9P0X4"}
{"id":"f4885c5a-2901-4cc5-b6bb-0a2120cb5a1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:11ec5319-c4e9-4b3f-ab9c-81069a6d6146","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P07333"}
{"id":"c0373815-ec05-4f73-8081-e8b60399c2dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3G4GVP38EC","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:0d7deef7-1a7f-4b3b-b13d-26ee3d4b5fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5095","original_object":"UniProtKB:P17752"}
{"id":"5331da1c-1a91-4bb6-84c7-24d15ec96100","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34849","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:e2265608-830b-4f29-b158-5f0ecb6c7ff5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2859","original_object":"UniProtKB:P10275"}
{"id":"8392b753-101b-4697-a1fb-7d8140154f31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10904818","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:3f7b1fa9-c7ba-47e5-8794-297ffa28e1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2937","original_object":"UniProtKB:Q9H228"}
{"id":"31c27307-f963-4770-a1ca-148f9f4987fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91409","predicate":"biolink:affects","object":"NCBIGene:4486","sources":[{"id":"urn:uuid:176d0101-6507-4685-a5a7-01c987ca646d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7953","original_object":"UniProtKB:Q04912"}
{"id":"dec30df1-0271-4afc-b593-d599851ac58a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9058I8S63D","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:8ffc282f-5a16-4dfe-b767-b3f76f5300c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8012","original_object":"UniProtKB:O00329"}
{"id":"b861ef03-4366-49a7-a1b2-ec19bbcf60b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5PI41O6ETI","predicate":"biolink:affects","object":"NCBIGene:3067","sources":[{"id":"urn:uuid:9a4ca5d3-2b08-4def-b1cd-5c93e89b5669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5189","original_object":"UniProtKB:P19113"}
{"id":"7477fb25-aafa-4b92-9ab7-433e73fc52a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11646235","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:56161af3-34cf-48bc-84d6-f780186b0e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12859","original_object":"UniProtKB:O14843"}
{"id":"3d85a6e4-9644-4ce3-8f71-20f5129c2692","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177197","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:43bc814f-bc2e-43da-8214-0deb3218803f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2082","original_object":"UniProtKB:P31391"}
{"id":"6d3e6e02-f32c-46cd-b35d-a5b1909f1eaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40SGR63TGL","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:b9c9a024-4473-41f4-8d26-9c99f0119c28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3164","original_object":"UniProtKB:P14324"}
{"id":"2981c0bf-46ff-4af0-834e-3ddd7b2e13c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2549","predicate":"biolink:affects","object":"NCBIGene:24520","sources":[{"id":"urn:uuid:e98dda55-e75e-422b-92b1-71a7b233614c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2549","original_object":"UniProtKB:P10499"}
{"id":"2cba71a3-39b0-459d-8c92-6b2d5c67797a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:63V8AIE65T","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:a645e5cd-c6d6-44fa-bf88-63a7bb837afd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7972","original_object":"UniProtKB:P22001"}
{"id":"35cc7eac-df57-4d8c-88f8-1ac4ea55880f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13087","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:b4f5ca01-42e7-42f3-ba96-f91bad4e7567","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13087","original_object":"UniProtKB:P11836"}
{"id":"53d0674d-e553-4e16-8574-e66a3f9453a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1518","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:efa6e4e9-7db8-45d3-a600-ec9907ec9552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9781","original_object":"UniProtKB:Q99788"}
{"id":"af95631f-deca-4c0b-9505-9572d5887fe3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95255","predicate":"biolink:affects","object":"NCBIGene:50839","sources":[{"id":"urn:uuid:45b53b7a-02f9-417d-a885-08d4d1f7539b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12433","original_object":"UniProtKB:Q9NYW0"}
{"id":"1f5d8612-77ae-4855-b73f-13135ca6702e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233090","predicate":"biolink:affects","object":"NCBIGene:153201","sources":[{"id":"urn:uuid:a44277fa-aa6e-4eeb-86f0-10cfde7fb775","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4693","original_object":"UniProtKB:Q495M3"}
{"id":"2ce36334-f227-462a-99a5-ab296161fcde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:9971ac71-f203-49b5-961d-a26ebaee726a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P16388"}
{"id":"f122eadf-ac3b-4610-b6a1-3a08d6e5a3be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553161","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:e0f76dd8-299d-47f1-a8b5-bf806164af07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10235","original_object":"UniProtKB:P30542"}
{"id":"1f679168-4457-4c71-95af-3bdcb0dc5ee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146026048","predicate":"biolink:affects","object":"NCBIGene:55170","sources":[{"id":"urn:uuid:5b47bc55-946a-4c78-9698-c76700e95902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11423","original_object":"UniProtKB:Q96LA8"}
{"id":"58e26af3-85c0-4fd8-b45a-09e40f733d31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177440","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:4fc36e3f-28b5-4218-aeaa-4125be71e53e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1640","original_object":"UniProtKB:P41143"}
{"id":"75a20243-338a-4fc6-8608-1dfaed97d48e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31882","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:1e225d30-bf3e-4864-9d03-33b5e076fe08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4268","original_object":"UniProtKB:Q12879"}
{"id":"32e27256-e9db-40ff-93b1-8898e3afc751","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813898","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:929c1637-3dfa-4524-b504-08ed1a665cfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8972","original_object":"UniProtKB:P48546"}
{"id":"3524c4e6-c38d-4ba3-afcd-7181580f9774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5780","predicate":"biolink:affects","object":"NCBIGene:319430","sources":[{"id":"urn:uuid:a1594c54-7a50-4c18-9ef2-72dc365c3022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5780","original_object":"UniProtKB:Q8BW93"}
{"id":"6fbf0ad3-78c7-431c-b4d7-62942c02ebc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947515","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:aef4f8b8-2196-481f-a658-58457a4b4c6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9916","original_object":"UniProtKB:P42345"}
{"id":"eb8dc32c-f8a2-41f4-b013-c0e55a4a241d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JTZ51LIXN4","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:b51e4956-cb5d-4c9a-bbe5-97e127931529","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11413","original_object":"UniProtKB:P42680"}
{"id":"aaf1af43-aefc-4c7e-a4d4-7eddb0ca39f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:102414","sources":[{"id":"urn:uuid:5e51b124-b4bb-4b83-b66b-95b9e82e4bde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:O35492"}
{"id":"f704d56b-c7e0-4e30-a304-92237b5f817c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4164","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:5a2553de-8d89-4aad-9003-bf6442363ca2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4164","original_object":"UniProtKB:O75762"}
{"id":"65f24cd8-800c-40e3-9b5c-78fcd5d86fe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144948","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:23010f7e-03fe-4e36-a229-3a36c3c233db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3324","original_object":"UniProtKB:Q99500"}
{"id":"5eecd874-0670-4486-aea3-3f78c4dfa878","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43876","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:d086e828-4de9-4ba4-8a00-ad9c8ef30445","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1373","original_object":"UniProtKB:P31424"}
{"id":"d904733c-b1d0-4b90-a813-724ea9d14e6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:272","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:7045e26b-f2e4-477b-92ea-0999ab31945a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1647","original_object":"UniProtKB:P35372"}
{"id":"ea87641b-a2d1-4e95-bd7d-8519ce5d4437","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817486","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:41e6b18c-c7ff-4023-a81d-9251a507a202","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6123","original_object":"UniProtKB:O08726"}
{"id":"80d39eea-e13e-4f40-a389-81e741e288e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45375987","predicate":"biolink:affects","object":"NCBIGene:27102","sources":[{"id":"urn:uuid:46ca7d9c-5b76-4267-adff-34a83a82dddd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8168","original_object":"UniProtKB:Q9BQI3"}
{"id":"3138815e-948e-432a-8a46-f801e48e2840","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6710","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:ddfce2ff-be48-4d9e-9f0e-c3a02172f723","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7219","original_object":"UniProtKB:Q8TD43"}
{"id":"f4f7fc4b-e692-4367-b04d-3a5e7e344795","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:4314","sources":[{"id":"urn:uuid:4880018d-fa88-4e8e-aa8f-7e00feaec3fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:P08254"}
{"id":"d5b79c3d-27c9-4549-b8e5-68d755b0ba9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:e4c4500e-ec7e-44b4-9e6b-8ed460b51aee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:P35498"}
{"id":"cf6ffdb3-19e1-4c05-9bb1-26c0ccb10ca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:187403","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:16de9d8d-e7e1-486a-9a98-082ee5a5efa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2753","original_object":"UniProtKB:Q13133"}
{"id":"2d3c5fe1-39e7-4936-b35f-35e6f86fb9ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90685","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:d3ce4de6-ffcb-463d-8b38-8a29b96f73dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9915","original_object":"UniProtKB:P45984"}
{"id":"12f1b159-57d7-4f67-a519-02590aab97fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:256c21b7-50fc-4dc4-a32a-1c7e52ffb71f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q9UKV0"}
{"id":"2bb5b219-37c3-4c11-ba8f-71dc10149560","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2H6KVC5E76","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:4dcbe55e-5341-4f54-afee-e58b951e1302","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4277","original_object":"UniProtKB:P14867"}
{"id":"c2f62d85-1cc8-4cef-b1ad-573eee4f4e00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:f6442532-a125-4952-8af4-dd522090daff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:Q91ZY1"}
{"id":"2a6048e8-ddac-4b55-8c42-96c37d2e4f84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54585928","predicate":"biolink:affects","object":"NCBIGene:9507","sources":[{"id":"urn:uuid:d804d733-f7fa-47aa-80f7-25a1348b60d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8553","original_object":"UniProtKB:O75173"}
{"id":"994d9713-c12c-4c0c-9a4d-8a650e181036","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11076","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:f7c5e473-0ff7-4a72-b3d5-f6b5d9a90717","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11076","original_object":"UniProtKB:P0DTC2"}
{"id":"be7da9a2-f458-4ac1-8495-33d416197580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167695","predicate":"biolink:affects","object":"NCBIGene:2923","sources":[{"id":"urn:uuid:a334c7a6-4256-401a-9923-c5c16fff73ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13430","original_object":"UniProtKB:P30101"}
{"id":"528c7a48-45a2-43fb-8d0e-6a0384c7a27a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17115","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:3cc77116-6ea6-46a6-abe0-31f454e75a33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4171","original_object":"UniProtKB:Q14957"}
{"id":"878e1250-aace-4314-93c7-7d7a220bd3e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135181440","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:fa4f909d-608c-431d-99e6-2ba6314443c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12869","original_object":"UniProtKB:P22455"}
{"id":"5fe73f5e-0e50-4b4b-a41d-6b30df0cfc8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:54a36131-a490-4d55-ad8a-06b12b46ddcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:Q16445"}
{"id":"1297b989-ee70-4f81-b48b-87742e307fad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:39HBQ4A67L","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:8a244d33-3d81-45f7-b4d0-9e8321aded52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10468","original_object":"UniProtKB:P00533"}
{"id":"26870e66-3222-4a68-9c08-2f3a6fdca5bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WK019939LW","predicate":"biolink:affects","object":"NCBIGene:7054","sources":[{"id":"urn:uuid:dee2dfa4-3222-4827-b7c5-7bcbc608588e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5114","original_object":"UniProtKB:P07101"}
{"id":"0d7c9826-3a48-4aba-b216-020ddf15e44f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:e6eb6056-70b9-45bf-a07b-dffba8704b6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:Q12866"}
{"id":"fbf78820-bf60-4934-a15a-96471d1be99a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188811","predicate":"biolink:affects","object":"NCBIGene:54814","sources":[{"id":"urn:uuid:e1e53831-ab9b-49c6-bf1c-cc30c8b8fbf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13399","original_object":"UniProtKB:Q9NXS2"}
{"id":"0b09c393-6c5b-47d7-ab85-bb6da4ea94a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92503","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:fee858ee-2d62-43b4-a475-90635395da8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5167","original_object":"UniProtKB:Q14432"}
{"id":"e1348ea3-09b8-4cc0-b8e9-3da3f5c1c75d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131156","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:6dd6e50c-5163-4349-b4c8-1389818a0616","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7713","original_object":"UniProtKB:O96017"}
{"id":"2d5760c5-7322-403d-bbd0-e062353a5a0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11125","predicate":"biolink:affects","object":"NCBIGene:14917","sources":[{"id":"urn:uuid:f1f45ad6-5a27-4203-b2b1-5fa69baccc87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11125","original_object":"UniProtKB:Q3UWA6"}
{"id":"7f0f574b-8b87-4162-975a-a57aec459407","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:114862","sources":[{"id":"urn:uuid:fddb238d-728e-4cac-ac11-39d3851cba9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:90","original_object":"UniProtKB:Q9EQ60"}
{"id":"2169a6f3-5b98-4dde-9df6-63f51cd5e5b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280454","predicate":"biolink:affects","object":"NCBIGene:5164","sources":[{"id":"urn:uuid:91b4f068-f3ad-42bd-a2cb-725bae253b30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9350","original_object":"UniProtKB:Q15119"}
{"id":"fcad917f-79bf-4e71-9568-788f689d957f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:efdabbcb-c148-4afb-8e92-a5bac9dc2519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P08588"}
{"id":"420ee9c0-e027-41dc-94b0-39cabd159206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1867","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:7f99168d-49f1-4b6e-b6b1-cbaf604123ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1867","original_object":"UniProtKB:Q8TCW9"}
{"id":"5342211c-7c38-4f6b-8d10-68fad87928c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54669783","predicate":"biolink:affects","object":"NCBIGene:29943","sources":[{"id":"urn:uuid:dcb40181-bbf9-430d-9080-64377df6eb53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8625","original_object":"UniProtKB:Q9ULC6"}
{"id":"cf720739-1afe-454c-af23-5be46fed6286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"UniProtKB:P30940","sources":[{"id":"urn:uuid:cd34f739-9b0a-40d6-8084-37693d8195b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P30940"}
{"id":"55e470b6-93ea-4c79-be85-13dceced991d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:71f74896-f6ed-4467-9671-c645037ca0a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:Q63634"}
{"id":"b5c0d0bd-e41d-4cc1-99f1-3fe2bbe01b27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:2ffd10bf-de54-404f-ab46-816489ec926f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P50406"}
{"id":"73676955-1fcc-4ce8-a6a6-a4c59c496db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611894","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:bda2b0bf-0d62-49e8-b447-9d0f2a592070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9997","original_object":"UniProtKB:P48736"}
{"id":"6409f22c-6604-4c95-b4f1-567e581b0d6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135261","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:4986a2ef-4db0-49f6-bafd-6fa13020c9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:569","original_object":"UniProtKB:P07550"}
{"id":"d2ac5212-b144-47b6-b2c3-de3e4c9e6f06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:c6dc8230-39e5-4165-b2d5-bcb96f196768","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P11229"}
{"id":"d5271789-83dc-4cd6-b0b3-c39f3ee0c26b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47924","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:50632713-e6d5-4c77-8566-1e3b300f6c07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7914","original_object":"UniProtKB:Q13490"}
{"id":"427149bc-5ea5-46b6-9714-37f9ed343780","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34968","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:b5dcc5f8-0b61-4ba5-86de-c2a485f59c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4197","original_object":"UniProtKB:P34903"}
{"id":"e1a221be-a08e-4ff0-8d4d-8b3d21699693","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CUJ2MVI71Y","predicate":"biolink:affects","object":"NCBIGene:3559","sources":[{"id":"urn:uuid:18a91fcd-a8ef-4fc2-816b-75e624be9b27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6880","original_object":"UniProtKB:P01589"}
{"id":"9dfa8dca-c1b2-4b52-83cf-6ed404d5b991","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699452","predicate":"biolink:affects","object":"NCBIGene:165679","sources":[{"id":"urn:uuid:07274fe7-2c2a-4633-9457-7c93a6c93dcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11157","original_object":"UniProtKB:Q8NFR3"}
{"id":"3d8d1ed0-5aef-42a8-a071-40cb65ce1a45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312129","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:4fc3472f-1009-4edf-b173-eef043d727f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1952","original_object":"UniProtKB:P35408"}
{"id":"cb2dd2d3-857a-4c46-b783-9db823c98c17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:447181","predicate":"biolink:affects","object":"NCBIGene:23576","sources":[{"id":"urn:uuid:4cb93f3b-0183-4271-bf94-a54f7bf4c52e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8830","original_object":"UniProtKB:O94760"}
{"id":"51995ffa-a22a-4ffe-8659-5f9814ddb72b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:632","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:cf4dc817-cedd-4e81-97ad-b2f4f2befc45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:632","original_object":"UniProtKB:P28336"}
{"id":"22985032-e6f5-473b-b601-578f1359990c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:a5200dac-7b40-46a3-8e36-488cf685dcc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:Q03181"}
{"id":"48a7ee10-d2e5-4468-8e8d-0f6f0b52a5cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9870523","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:3a8e0053-4cee-4e4a-86b9-52271086f777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1362","original_object":"UniProtKB:P49286"}
{"id":"5a69e9a3-b2a6-45fd-87c6-cd30f9911115","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117961403","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:20890d13-2845-4cc0-828a-47b20cd9b11e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10394","original_object":"UniProtKB:P56817"}
{"id":"f9328df1-e420-43fe-bf32-7525c2da78b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H4X2M2NN5N","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:4a8b1364-e3fc-47fe-9a79-49708679f56b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9921","original_object":"UniProtKB:P09619"}
{"id":"3557ca2a-daa9-4c76-896b-3da74004e8aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:490561","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:8de697cf-03c5-41ef-9e0d-8023b6118a42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:336","original_object":"UniProtKB:O95835"}
{"id":"d06f3bf5-dec4-446b-be1d-aace61d3df49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10287730","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d0c1a608-71ef-4b68-a613-d3abf44f597f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:77","original_object":"UniProtKB:P08908"}
{"id":"de980159-d4f8-42a1-afe2-584efc4e11b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93613","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:ceb3c3f6-5560-4238-bcc3-e649ff4858cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2358","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"29ad7d23-aaf3-4182-965f-48424291bb70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142418","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:11894625-3ada-48b0-8045-778cea66bcfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10100","original_object":"UniProtKB:P26255"}
{"id":"74e46816-a185-4ad2-a4d3-cf59a9054402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231951","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:ae28094a-519b-4e6c-a93f-ee4ce5bcb8db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12064","original_object":"UniProtKB:P43220"}
{"id":"a0c08bda-c2c6-4a9a-a93b-9d4685c916a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132986","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:b8a2010f-83b9-429f-b9e9-c07b6ac57e10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7717","original_object":"UniProtKB:P21860"}
{"id":"bf2fcd36-249f-4c2a-b1a1-05bf25399b8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GE2T1418SV","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:0810ff2b-9ecc-411b-bb10-a72dffec70af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7354","original_object":"UniProtKB:P08173"}
{"id":"0c012f92-b070-4cde-bc6c-2bf322fbaf8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73348907","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:8b05ae18-2609-4b46-91cb-226ee98782f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8132","original_object":"UniProtKB:Q13177"}
{"id":"8f8ba418-b0a6-4e70-9dde-e4191019b189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345449","predicate":"biolink:affects","object":"NCBIGene:3760","sources":[{"id":"urn:uuid:9920c348-4ddb-44ea-b451-51be9f4f5f62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7704","original_object":"UniProtKB:P48549"}
{"id":"19dd1afb-62e0-4adc-9848-0f7b3f3f9541","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16062593","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:043f3753-db57-4fb5-b27d-cce1e363305d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1407","original_object":"UniProtKB:O00222"}
{"id":"7cd8de93-ca24-40c7-872d-9254223edf2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2922","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:aca717cc-d2ec-4c8b-b8e4-94165fa52d7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6306","original_object":"UniProtKB:O75762"}
{"id":"9bfdab1c-f3ec-4f34-9295-a36b864dd46c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156273389","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:e5ad7470-7c32-4a2e-9f54-89e6de52d3c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12313","original_object":"UniProtKB:P11362"}
{"id":"e4921a31-fec8-463b-a1ee-b23b0fff9c35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123884","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:04218698-8763-42fd-baa3-102f9e1a2558","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:641","original_object":"UniProtKB:Q61125"}
{"id":"1f26e0f6-0abd-4804-aef2-1c5214e46897","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817415","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:1a35d2d4-430c-40b3-abe9-7d0b360937c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1482","original_object":"UniProtKB:Q9GZQ6"}
{"id":"3622d45d-5fd4-4106-ad52-f30845650482","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PX9FTM69BF","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:c19dae14-2b6a-4d86-ae38-ebaaa275c103","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11190","original_object":"UniProtKB:P10721"}
{"id":"c6c10617-8591-4568-a245-d58eaec1fbb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:13610","sources":[{"id":"urn:uuid:070f46c7-62b0-4938-bfdf-977072ef84ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q9Z0U9"}
{"id":"bcd7f7b5-7279-4ecb-b57c-886ed71ff12b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:29665","sources":[{"id":"urn:uuid:ac9c3aec-b8ee-41aa-8b2d-7452a727b77b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:Q64663"}
{"id":"500d4f99-42c7-446e-8d72-190a984d579f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:72AH61702G","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:77df94b8-9b53-4e83-8051-25302185cd17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7966","original_object":"UniProtKB:P00533"}
{"id":"b46d23c9-0c2b-4f5c-9b30-da100d083a06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GNW87JO5PF","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:e0fa1cc7-234e-464d-92b3-750ddf97c82b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10377","original_object":"UniProtKB:P34998"}
{"id":"f3c1fe6b-4148-4b53-ab09-06ed06b11f14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817521","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:abb85b6b-729a-495a-9807-888ed78cdad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11453","original_object":"UniProtKB:Q15391"}
{"id":"b7804009-afdf-49c6-ae10-2c4cef42893c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925839","predicate":"biolink:affects","object":"NCBIGene:10892","sources":[{"id":"urn:uuid:0d3f2c06-5356-4f41-8b5b-cd4d63eb7c2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11507","original_object":"UniProtKB:Q9UDY8"}
{"id":"f50a0d7c-f2a4-44b8-a1d7-e15ea3a760d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:06c8d676-21b8-45fd-949d-a0a2932da753","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P30994"}
{"id":"b75d0b79-c272-4d01-a0c0-08a6842e07af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:46D4HS9ODA","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:17262843-95f1-483f-b539-9b2942aefd06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9903","original_object":"UniProtKB:P24941"}
{"id":"ea4698d9-5138-43e3-a2e0-459d542129a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LMX71OP17X","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:6bdb357d-79a1-474a-a370-828b72dbcab8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1907","original_object":"UniProtKB:P43088"}
{"id":"ba390e0c-af4d-45bf-98ca-f4c613a1cecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76979","predicate":"biolink:affects","object":"NCBIGene:26946","sources":[{"id":"urn:uuid:7fbf3d7b-7981-471e-b7b0-418d87ee92ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2435","original_object":"UniProtKB:Q9WVC5"}
{"id":"93c13ccc-a1dc-456e-90a5-74b03b5f9dc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SA2ND7EHY4","predicate":"biolink:affects","object":"NCBIGene:65125","sources":[{"id":"urn:uuid:e5f40739-7e53-4167-bc05-55fc91bcf440","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8836","original_object":"UniProtKB:Q9H4A3"}
{"id":"409304f5-0a1d-4708-9e63-c4fb638a86ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030524","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:a550c879-8770-4955-a81a-1214039d0fa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10443","original_object":"UniProtKB:P29274"}
{"id":"17eaf474-41bb-41b4-a0d1-2fabee08b9a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519431","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:123ec803-c650-4a8e-a9bb-7e5b715e366b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5555","original_object":"UniProtKB:P25090"}
{"id":"7210cff5-48ae-48fb-b069-3d336ba19422","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122211","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:19a21dc0-254d-483a-8a41-cd68f1e67b2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:524","original_object":"UniProtKB:P08913"}
{"id":"e85838d8-cd27-447e-b03d-4558739ccc5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:f391e674-a3a7-4c09-a466-75543d7120b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P14416"}
{"id":"13b4ce5b-3399-423b-b962-bb4450478387","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6095","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:436f9d91-d71c-4493-9aa6-96830ddd99ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6095","original_object":"UniProtKB:O43603"}
{"id":"557fece9-93ea-4dfb-b739-194aaebbc0f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4PK52982QT","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:c10b8317-a7a9-4a31-aa2b-cc07f448a9c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3360","original_object":"UniProtKB:P34995"}
{"id":"880b784e-8da9-4d04-8be8-6ff8ced0d195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:8601be8a-4fc8-4cf2-846b-9a2118bd8f86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P30680"}
{"id":"16068b1f-7d99-438e-b0c4-bc73168a5fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155587867","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:808fb1b7-e7cc-443e-9902-e14a3c662556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11510","original_object":"UniProtKB:P07333"}
{"id":"d6149cb2-121b-4a38-9fe4-ad67153baa7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134724","predicate":"biolink:affects","object":"NCBIGene:64522","sources":[{"id":"urn:uuid:8454f97f-fc8b-4773-a701-5b44c0a75bf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9394","original_object":"UniProtKB:P53792"}
{"id":"6f700580-6edd-4355-87ae-b344b5ea65a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1117","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:104b4cbe-b246-4e6f-8b00-4d49681c2972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1117","original_object":"UniProtKB:Q02644"}
{"id":"3fda4866-afc5-44f4-8a4f-bab2022a2631","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91194","predicate":"biolink:affects","object":"NCBIGene:53836","sources":[{"id":"urn:uuid:0edf496f-fcd2-4245-a4a5-98354049c0b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2907","original_object":"UniProtKB:Q9BY21"}
{"id":"fc1c2959-18f5-4e92-9b67-5ee5cfe2a086","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:bf9a714f-1962-43c8-9d96-00b8fb590ee7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q12791"}
{"id":"d3fbe23b-8056-47a3-a6b7-c1eae7e29eed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:1c60f793-c92e-40b3-bb99-a3bfaeb1321c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:P07949"}
{"id":"7e1c0324-c34b-4564-80cb-84bec2510d9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5547","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:46af8036-a6ac-46f8-860a-a22daab4ca8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12468","original_object":"UniProtKB:P59537"}
{"id":"e87de619-826c-4786-84b5-b8b912f62baf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10104167","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:811dd27b-17f4-4efe-8389-a5ee1961f80d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6937","original_object":"UniProtKB:P08172"}
{"id":"cf22e7c1-9e5b-4cb9-ab52-1dcdb7bcc962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:6f9169f1-4820-4c9f-a693-8e6acf734abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P35968"}
{"id":"a23e80c3-ef88-475b-8db2-a5f7d7353ab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:2b62b108-7f57-4fd0-80a7-896d8cc57166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:P50750"}
{"id":"707e639e-808b-423d-b0e3-a93c2c30ec1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48273","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:26823f36-2a13-4571-abae-dcbc4f56e1b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:51","original_object":"UniProtKB:P28222"}
{"id":"7b14382c-83f8-486a-b40e-05d575edae55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HD4TW8S2VK","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:3ebd86c8-f236-4d05-922c-61e9a80cf0b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13833","original_object":"UniProtKB:Q99720"}
{"id":"0c319348-0079-4144-810a-02658e85e79f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:5b1c5a45-560c-49a5-81a4-8781ce5d9fc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P21728"}
{"id":"9bf65bff-f280-4792-bb58-cb5900930923","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11749893","predicate":"biolink:affects","object":"NCBIGene:232333","sources":[{"id":"urn:uuid:9577c737-3856-4d24-97b0-cbe6a829bde3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4756","original_object":"UniProtKB:P31648"}
{"id":"8ecfd96a-e0a6-405e-88ba-6bba02a49d4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13848","predicate":"biolink:affects","object":"NCBIGene:4836","sources":[{"id":"urn:uuid:9a8cb0e0-4c36-44bf-bb69-1c1ad2c42c6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13848","original_object":"UniProtKB:P30419"}
{"id":"ff21b53f-81bb-4113-a51e-4cdbbd5cc6f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O8E148Q90M","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:13ac1302-eda4-4722-9bda-b756199ae956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12752","original_object":"UniProtKB:P34972"}
{"id":"746245b9-2778-4dba-b14a-1a82e3f71746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163410393","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:1834ad72-7b85-4688-89c0-f9b4ea4cab4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12057","original_object":"UniProtKB:P14780"}
{"id":"ed3a035b-3531-4057-9f59-b49cba4d2365","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:147411","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:30133fc2-474e-46a2-96a3-e92ce849b09d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5977","original_object":"UniProtKB:P49841"}
{"id":"25f2e8c3-ca3e-4e8c-90d2-baabfd95a646","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46195","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:c41e3ca4-1d81-4969-a79e-d38ff4e479ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5239","original_object":"UniProtKB:Q9HBA0"}
{"id":"db03e57c-3d99-47e4-b7b8-afe4cd6b8a3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137977202","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:ee5aa669-42ec-4190-9c4a-dd8c67bc50a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10665","original_object":"UniProtKB:P49286"}
{"id":"78cd661b-a520-49ea-bcfe-5de2cec66da6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O9H5KY11SV","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:aefc89a5-2079-4a92-8ffd-90112acb2fa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10883","original_object":"UniProtKB:P0C6U8"}
{"id":"d5dc37b3-7385-469f-8596-bae332fdf111","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:810","predicate":"biolink:affects","object":"NCBIGene:9034","sources":[{"id":"urn:uuid:21dd55b8-dfee-4aa8-8ab8-94be787799f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:810","original_object":"UniProtKB:O00421"}
{"id":"ffe4d420-96c8-4c2c-9525-bf5fc3cbd370","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072548","predicate":"biolink:affects","object":"NCBIGene:84787","sources":[{"id":"urn:uuid:342acff6-8dbb-413d-a724-d9bd4caad86f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8949","original_object":"UniProtKB:Q86Y97"}
{"id":"cb031329-4d59-4f3f-8498-097f1b205d18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:1187","sources":[{"id":"urn:uuid:a6351849-a175-489c-8153-c431d342127b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2439","original_object":"UniProtKB:P51800"}
{"id":"4094de0a-2ea6-4cf6-aa60-6205b819be0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27958","predicate":"biolink:affects","object":"NCBIGene:24898","sources":[{"id":"urn:uuid:1cfa8c7d-f7e6-476a-b6c7-e473670aa882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2286","original_object":"UniProtKB:P23977"}
{"id":"6ba8d04c-976e-4694-8e75-fdf1554ba89a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60204017","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:94cd47ba-06e1-4e5b-865c-42575b0f3e36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8765","original_object":"UniProtKB:P31422"}
{"id":"fde6ee4f-5d94-4365-b381-7f5b450a65e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:c0180187-b739-4bf8-90f0-5f9ad0facd95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P29274"}
{"id":"a46a4aec-dbc4-40a1-b980-c733d875874c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44353781","predicate":"biolink:affects","object":"NCBIGene:824","sources":[{"id":"urn:uuid:8e5e771b-a9ee-4c0f-be2c-5b0d7755abf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8569","original_object":"UniProtKB:P17655"}
{"id":"6a75a4f9-5270-400c-9007-bbe6d0ca325a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:23606722-49d1-4da4-83ce-40a2e5af9707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:O60885"}
{"id":"7c7adfb3-d3c6-43c7-bf5f-886b1485161e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:45f7876f-25ef-4d58-b39a-037314dd928b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q13936"}
{"id":"0eb187ea-b12d-43b4-9a6e-f38beb5fdef4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54596718","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:177f45c9-b2da-408e-8144-3c4020046dff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8662","original_object":"UniProtKB:P06401"}
{"id":"c51fccb3-141a-46f7-8e6b-1ee9e3d60a63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1294","predicate":"biolink:affects","object":"NCBIGene:83567","sources":[{"id":"urn:uuid:3ac7c1cf-cf75-4688-aca6-93394725b030","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1294","original_object":"UniProtKB:P97639"}
{"id":"ab65cf91-bc0b-44f9-8976-ac9e89aee62d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1307","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:584128b3-3236-4c1f-8158-cc8c067b8409","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1307","original_object":"UniProtKB:Q99705"}
{"id":"642afbfe-507a-4b22-bc8f-8614a5688fa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:86a364e7-6cd9-4829-8106-899e41463cc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:P50750"}
{"id":"5204f3ca-32b7-46a7-8d2a-58af7c91f412","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31596","predicate":"biolink:affects","object":"NCBIGene:7498","sources":[{"id":"urn:uuid:f9fface4-780d-46b4-b642-af97d70b65dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6817","original_object":"UniProtKB:P47989"}
{"id":"7f4f3895-62a4-4b3e-9f64-643be291f58b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90170031","predicate":"biolink:affects","object":"NCBIGene:6768","sources":[{"id":"urn:uuid:6e76187f-ce12-4a6a-99df-840a8c610678","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8483","original_object":"UniProtKB:Q9Y5Y6"}
{"id":"de8211fa-332b-4025-b130-d39068f4a3a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92338","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:77bddbf2-b047-4011-ba90-1f1f28f60648","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11742","original_object":"UniProtKB:P21397"}
{"id":"c472d4d0-f379-40ae-9600-7daa2ab2ec7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49871766","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:731c38e3-4099-40b3-a319-d16df3ff4c5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6170","original_object":"UniProtKB:P28336"}
{"id":"4259d6e6-a64a-4e03-a640-eae7393b8f28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189662","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:44d159af-5bda-43a8-baa7-525c2cd4917d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8113","original_object":"UniProtKB:P11309"}
{"id":"a6202594-c8f9-4b9d-949d-0bbbd29b7504","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2316","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:2014ab24-2507-4071-b421-96d2b86e1860","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2316","original_object":"UniProtKB:P70604"}
{"id":"6d6f12ae-12bd-4c0d-9638-f97adabf9417","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:0c2dc68d-1312-46da-99e4-338336138f50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P30994"}
{"id":"3f5115e6-dcef-4607-bd4f-535d02a89707","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162625114","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:7656d391-0bfc-42bb-a6c6-3b8c6eef79da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11840","original_object":"UniProtKB:P0DTD1"}
{"id":"5c29cc76-5677-4330-9b5c-e47186992453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53318014","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:ef2b6c00-5d0c-4433-8a37-a88b1185159c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:118","original_object":"UniProtKB:P28221"}
{"id":"5acd9c4f-da28-433a-8e87-573198236d28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7582","predicate":"biolink:affects","object":"NCBIGene:682930","sources":[{"id":"urn:uuid:69f60c9a-03c0-44b8-adbd-1e3364e5cc57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2334","original_object":"UniProtKB:Q02485"}
{"id":"fbdd871e-d5b4-4e31-a55b-ec3fee7352d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P7T269PR6S","predicate":"biolink:affects","object":"NCBIGene:1071","sources":[{"id":"urn:uuid:5e622039-97e5-45eb-a773-5436ebcb0774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8400","original_object":"UniProtKB:P11597"}
{"id":"f60be98b-6ec9-461d-a4da-c5e3a9cc8539","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64210","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:2a444f83-79d3-410a-a844-125a3db43bdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2647","original_object":"UniProtKB:P10276"}
{"id":"29ecbca5-ca1f-4fbb-8a40-67cad761bdf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16172435","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:48664399-8229-4448-a884-2d97472aba96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:991","original_object":"UniProtKB:P25101"}
{"id":"4e8a5845-7caa-4ee2-a0cd-fb19b0b72049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8983","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:752dc341-9fb2-46d5-b42b-2bcb77c4f03a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11391","original_object":"UniProtKB:P35354"}
{"id":"ed2257f5-caf7-40e4-9856-59fe539dbeb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081963","predicate":"biolink:affects","object":"NCBIGene:1565","sources":[{"id":"urn:uuid:7e1d9cd1-8996-4719-aef1-722385c98355","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9883","original_object":"UniProtKB:P10635"}
{"id":"8cafe9a8-3571-4d87-b367-99d4288bcfbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:64CW205BDD","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:cac60033-f7ff-41af-ac9e-b3e2fdd12e87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9800","original_object":"UniProtKB:P42336"}
{"id":"5293dffe-663b-4bcd-932e-f71ef7737593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10385240","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:46d888ff-ad8a-493f-9588-150424b530b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:182","original_object":"UniProtKB:P28223"}
{"id":"be11a09e-ebfe-4671-80c6-036879dbc38b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76254","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:7b38dd24-91ee-43fe-9698-2af34b92c8df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9551","original_object":"UniProtKB:P35354"}
{"id":"c51365d9-5161-4d51-8b28-66038f182dbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13660","predicate":"biolink:affects","object":"NCBIGene:23129","sources":[{"id":"urn:uuid:c953065e-6cb6-42c1-ae75-0afcf3c45c0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13660","original_object":"UniProtKB:Q9Y4D7"}
{"id":"20b410b6-428f-4da6-a994-7f0673841df6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4021","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:2b2c9ffa-fc2a-4fd6-b050-7c0577b69175","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10328","original_object":"UniProtKB:P56726"}
{"id":"6564d016-7c02-4d4d-8480-80b15ecfb849","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34558","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:68a9099e-aff2-48ba-9fe8-9a9f6f1888e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4145","original_object":"UniProtKB:P78348"}
{"id":"88523c1d-5cbc-424e-8dbd-b51e06610531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:208458","predicate":"biolink:affects","object":"NCBIGene:387893","sources":[{"id":"urn:uuid:29e2ff95-e3a5-4d43-a372-3701c3ed9873","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7022","original_object":"UniProtKB:Q9NQR1"}
{"id":"de47417f-ed0a-40c3-b12b-f9202d1d3184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2039","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:5762d193-7b90-4a9b-aaa2-f646f1661fc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2039","original_object":"UniProtKB:P30875"}
{"id":"bdea7f32-9dc1-41df-b34d-9b336cf53b22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59332591","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:3ebbc467-0042-464d-9086-cd48bdd622ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10134","original_object":"UniProtKB:O14920"}
{"id":"bb5ce192-539d-462f-91a0-8d9ef2983069","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71460944","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:919c912d-9764-4833-a752-008dcbe503d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11694","original_object":"UniProtKB:P41143"}
{"id":"8290ef8e-5cc6-4a82-b494-5edff1c3b973","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90545","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:9bf43f09-b2f3-435c-81f6-152963bebd99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7965","original_object":"UniProtKB:P42338"}
{"id":"77911635-4345-4308-92c0-adbf59814085","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GD8S432HM5","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:76f698dd-3d37-4107-ad65-52524ff19940","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5694","original_object":"UniProtKB:O14920"}
{"id":"4d807f64-a48c-4364-b2e6-22782568b379","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91799237","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:37da5c87-f01f-4e24-beb2-d16183b77473","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8590","original_object":"UniProtKB:Q92633"}
{"id":"ab4f3927-9ab1-465a-810d-d023f1a9a6e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9864831","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:9df3d9bd-b091-4f08-bdda-43146d0cb8bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5859","original_object":"UniProtKB:P35408"}
{"id":"a0ca584f-e00a-4087-a349-b4279dc0a26c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:dc416d63-b9fe-49cb-a7f0-4b65e6131c2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q96G91"}
{"id":"8f18fb7f-03ab-4105-9fc8-28a3f7c3cfbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135897","predicate":"biolink:affects","object":"NCBIGene:2280","sources":[{"id":"urn:uuid:97f2c1b6-4fa2-44e1-a216-bff5a7c4d441","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7974","original_object":"UniProtKB:P62942"}
{"id":"bbc2f460-be39-4189-9101-b0f7b2c64d8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25084484","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:319320a0-86a3-4bb8-83a4-c955fa64baf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3983","original_object":"UniProtKB:P02708"}
{"id":"a7f64af4-2cf4-47cb-9c36-68e55a3c3c99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54751698","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:4c885777-9cda-4bd1-bd7a-c78f3d9d044e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8968","original_object":"UniProtKB:P42336"}
{"id":"53219ee6-9f5f-4234-b9e2-60014321e453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151447433","predicate":"biolink:affects","object":"UniProtKB:P57059","sources":[{"id":"urn:uuid:0941eabd-572d-48b7-93bc-d3ec8d77cf7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13303","original_object":"UniProtKB:P57059"}
{"id":"8b12dbd2-4818-4fcd-89ba-19760d16a68a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:52e2fa86-47cc-48a6-9a00-687e72926cc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P31645"}
{"id":"606c9f8a-6e1f-4e5b-8f39-9dbb9531c6fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311175","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:9f7e39f4-0153-46b8-8126-ed40bad0f06a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1938","original_object":"UniProtKB:P21731"}
{"id":"da214038-4033-45e2-86ae-211096de1cc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87237","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:a070eb1e-27c5-4777-9bb4-68b8647fda3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8050","original_object":"UniProtKB:P48730"}
{"id":"3d629ff7-15a2-45d6-b44f-6a9a22db6859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:27334","sources":[{"id":"urn:uuid:ac5288b3-ee7d-4067-bb11-81f6705c109c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:O00398"}
{"id":"e7b3cc06-06c9-4c3c-a7b0-60dbb6661445","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P85X70RZWS","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:a625195d-3274-4323-83c8-d16095675481","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10773","original_object":"UniProtKB:Q16445"}
{"id":"45103c6f-70f1-4cf7-96d0-0aa87820c4ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368936","predicate":"biolink:affects","object":"NCBIGene:200576","sources":[{"id":"urn:uuid:d5507761-e43a-440d-8bfc-ffe4608dd44d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12185","original_object":"UniProtKB:Q9Y2I7"}
{"id":"577a76bd-8a5e-4f1d-b2c3-d0d6201586cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230017","predicate":"biolink:affects","object":"NCBIGene:79017","sources":[{"id":"urn:uuid:c6fafaa3-9a13-4f5c-96a8-0cda6d470579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10265","original_object":"UniProtKB:O75223"}
{"id":"6d657c9e-1f6a-484c-9572-d7a64199e107","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8665","predicate":"biolink:affects","object":"NCBIGene:590","sources":[{"id":"urn:uuid:ba9cc67d-60b7-4a64-a8e3-370561e24693","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8994","original_object":"UniProtKB:P06276"}
{"id":"492d5f41-554f-4f3f-ad7d-617d3fbc859e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:eea8a3d5-e4c9-4895-8cb5-ce53506a6b10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:P70604"}
{"id":"3f595932-eb3f-4d5e-a8c7-1463679b7374","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XK5ILZ28KI","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:45de1664-eea5-455f-9cf5-a3d70a6795aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10452","original_object":"UniProtKB:P41143"}
{"id":"07b6d875-ff6e-4b8b-b617-7a31d920dcd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10213684","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:8a1fb993-82f7-4326-b0b5-9c1ee46d3c51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2152","original_object":"UniProtKB:Q9UKP6"}
{"id":"d4d3cf5c-5a61-4207-9dac-8d35ea9d7592","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156022820","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:a596bf82-7351-44ad-96d4-3e4c8613955c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11777","original_object":"UniProtKB:P25440"}
{"id":"734d63fa-329f-4c9a-8e29-97afa0347e39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441293","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:efa03031-d27a-4337-9267-aa1d67eeed12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1861","original_object":"UniProtKB:Q62035"}
{"id":"b8165ac8-5b52-4269-83b3-fa441c318eac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600315","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:4874edf5-0d72-4cdf-9f6b-ddfd8c4b2560","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10688","original_object":"UniProtKB:P49841"}
{"id":"b1ca6dbe-c0a7-4073-ade9-03e216a123c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138670","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:4adfd9ea-726b-4a44-a360-4da189c928cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9839","original_object":"UniProtKB:P53667"}
{"id":"c65954c1-d486-417f-b406-d483d4632f24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56835134","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:1e4a22c4-e777-4f8a-bdae-e78dfa544dd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7753","original_object":"UniProtKB:Q99705"}
{"id":"96dfcea7-f589-4f3d-9a64-1884c10ed08f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5128451","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:2dd0488e-cffc-460e-8e14-52123a6a6256","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:646","original_object":"UniProtKB:P46663"}
{"id":"cfcbf94b-950b-4123-ba68-d10d970d5980","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:48b9e310-1bc9-4154-9478-30d8e86cd488","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q92736"}
{"id":"90381323-c99f-4369-ab22-e8bcdfce0ec5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:69581981-012f-438d-87ce-25a51aa70908","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:O60674"}
{"id":"89d70bbd-46e2-439a-a4f6-28b0b9c62dae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TXG28R7G4Y","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:3464e6d2-9c0f-4f0d-8d20-9568e15ae1cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:496","original_object":"UniProtKB:P35348"}
{"id":"456d37e4-b672-46b2-9326-1936dc4af20b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072558","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:3d5cbfae-18bd-4139-8514-eeb61d0bd35c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9008","original_object":"UniProtKB:Q9HB89"}
{"id":"ccc2036d-e36e-4beb-a5ee-e664e48e1efb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11245456","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:0f9375ef-d6f6-47ac-8d23-acf459f4336f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1422","original_object":"UniProtKB:P41594"}
{"id":"627e1178-38f0-4f0f-a04a-8972b5728f14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755015","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:8744f73b-a6fe-4cc4-8824-9f87239215bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1841","original_object":"UniProtKB:Q62035"}
{"id":"c9cfc952-cdb4-422c-9b63-71e288a09744","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3440","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:6dcc96d9-a217-4a8c-a6a6-06e6f607a235","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2497","original_object":"UniProtKB:Q8K424"}
{"id":"9ccdfdcf-b5b2-4005-861c-39ca5309a4ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44400349","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:fd5bf14b-b854-4cab-8595-146fa83554a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2915","original_object":"UniProtKB:Q9UBY5"}
{"id":"91692895-74b3-4bca-8e8a-06a8b453dc54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:53be1c4f-11f1-4e83-baa7-994de7bd2363","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P07949"}
{"id":"eeb5a663-821a-477a-9860-a4410d5e4c12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G2AE2VE07O","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:00207d67-917a-40e6-b7e2-409764f1420a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10129","original_object":"UniProtKB:P20309"}
{"id":"ce1657ef-b2a2-44e9-be19-73a7f9b8caae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947040","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:30024c22-9ff3-4df8-b189-21156c31abfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3014","original_object":"UniProtKB:P04035"}
{"id":"9e065241-5005-4f70-8b7a-8be91c248827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93424","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:b4fc0c47-0ff4-4fb7-90f8-a3a26233693e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:403","original_object":"UniProtKB:P29274"}
{"id":"09dd893d-83fd-4d30-b278-383466c72efc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16761","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:19480bf7-b411-44cf-8ce3-8d4ebb550ed3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1712","original_object":"UniProtKB:Q96G91"}
{"id":"b13d8604-9f3f-46b7-b918-1abb1a7a8052","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817418","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:03827d1c-bfb4-4902-afe0-992b4e58f632","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1510","original_object":"UniProtKB:Q63447"}
{"id":"8fe827f4-43c9-4eaa-a319-e76058aee3df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:ebd9207b-2012-4455-af58-c3d92302454b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P28335"}
{"id":"6dc0ae7e-a18d-47da-a4c2-b1abef0dbcca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71739586","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:2815cf64-e0c2-466f-b580-fa4854571e66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11641","original_object":"UniProtKB:P0C6U8"}
{"id":"767b1b82-1311-4a3b-9be4-486d0baf68c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91455","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:f25394f4-1023-47e3-b640-86746f8ee649","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5192","original_object":"UniProtKB:P17252"}
{"id":"464d5eca-4cff-4e30-8a30-49a9b05a4579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16118537","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:7ce31164-8ba5-4d44-b749-58212e7c6ce5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6357","original_object":"UniProtKB:Q13255"}
{"id":"2d87a24f-ae30-4fff-990e-d64b00db4b4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7IK8Z952OK","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:d065cc8f-c5e0-4834-bf56-3c455abc6c7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9069","original_object":"UniProtKB:P25092"}
{"id":"092d374f-bd16-4d09-88d4-b115fa44d096","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:9887c47d-ddf4-4ef8-8156-f8e03d3ec131","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P51451"}
{"id":"f870a842-51b4-427f-a616-7a8d586d306f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90127874","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:b6fd8e96-48f7-4cca-bf9a-95ee8387ee44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9627","original_object":"UniProtKB:P27487"}
{"id":"ae11bc82-086b-4caa-a7b0-360afbf0c4fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:05c74231-ac6f-4bec-8e71-4c69aa9e028e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:P51813"}
{"id":"7abff472-e64b-4d7f-8c90-b30b678ac1d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10408514","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:168d80a7-f5b2-4743-a2b4-606775b81025","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4038","original_object":"UniProtKB:O43614"}
{"id":"d8689db0-c18c-4423-9b1f-39b8210bdcd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7907","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:b1e8220d-533e-441f-9eac-7ed16df9551c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4001","original_object":"UniProtKB:P02708"}
{"id":"02c8e10c-0fa2-4282-bf20-0cb7f19c9550","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:36736","predicate":"biolink:affects","object":"NCBIGene:24182","sources":[{"id":"urn:uuid:99b9c64c-a6f0-484e-a66d-504f73c1953e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:598","original_object":"UniProtKB:P35351"}
{"id":"ab99ab51-88d6-4609-8430-ccff7424ce77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:349149","sources":[{"id":"urn:uuid:42a3b8ac-4655-44d6-b63c-e40943b59af5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q8NFK1"}
{"id":"1ab921a6-4ecf-45b1-acb5-0ff962a37c84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136189563","predicate":"biolink:affects","object":"NCBIGene:23683","sources":[{"id":"urn:uuid:6a4c41a0-332f-4c1d-a7ea-3421596cc300","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8048","original_object":"UniProtKB:O94806"}
{"id":"2a72126c-ec03-45aa-a452-0343ec403f79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192640","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:662b97b4-d314-404a-a878-49d607dba356","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5206","original_object":"UniProtKB:O00519"}
{"id":"16dfbdeb-1325-4f00-90a1-fd2d73dc2243","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J241Y80EEO","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:245f8b09-1b65-4861-a078-b687cd2a6e11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13626","original_object":"UniProtKB:P08173"}
{"id":"6da320ce-b17c-4bc5-8cba-709831c6ae15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2618","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:92294631-1562-4f2d-b43f-435e5b1961b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4128","original_object":"UniProtKB:O15399"}
{"id":"47077531-cc6e-45e7-8eb6-f870d9679232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32076","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:eed641fb-fd91-4fa1-bcf4-d306107b5cf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2597","original_object":"UniProtKB:Q9NR82"}
{"id":"d66a41d0-5ef5-4dab-a43a-70654e8eecc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:9c7ec0de-e8d8-4aa7-a237-3eed2494edc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P08173"}
{"id":"6f79f8d2-b296-46f4-8f11-a2860a0ead47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58141","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:a33f034e-77ae-422d-bbfc-12dd530666c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1732","original_object":"UniProtKB:P41231"}
{"id":"c1932a9b-9bd4-4d41-96e1-b42808cf5aa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91563","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:5e2b99dc-2d39-49d5-ad80-6fbaed878654","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10555","original_object":"UniProtKB:P14618"}
{"id":"2c60f8a8-2dcc-40c8-81d0-37e8b1aeb2f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1578","predicate":"biolink:affects","object":"NCBIGene:64636","sources":[{"id":"urn:uuid:64ac8ed1-2720-4ff2-a050-67b4f79544e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1578","original_object":"UniProtKB:Q63384"}
{"id":"72e945ce-6275-43fe-b810-05fc024f338b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11476","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:d72bf3b1-af01-403a-a5b1-d18b02cf631e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11476","original_object":"UniProtKB:P63142"}
{"id":"09aad062-096b-4790-a7f3-20baf4f4e534","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15534","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:b4eaa4f4-87b9-4634-b4a1-d320a856feb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2386","original_object":"UniProtKB:P35561"}
{"id":"01b4d79c-cc49-4afe-9306-d1f9684baae8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5L84K4IEN9","predicate":"biolink:affects","object":"NCBIGene:5138","sources":[{"id":"urn:uuid:fa949065-48fc-4eb5-9940-ce27c869d6dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11626","original_object":"UniProtKB:O00408"}
{"id":"b50ed742-343f-441e-8825-730c5d26d664","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3441","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:83a82579-ab2e-43c1-9f43-5b802264d874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:551","original_object":"UniProtKB:P08588"}
{"id":"7f19fe78-24e6-440a-8581-d3aed4e30702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:775","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:f9f7f700-8302-44bf-96ce-cd6e99d0dd9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:775","original_object":"UniProtKB:P41597"}
{"id":"b9d01b69-ab23-4dd3-bae2-dcad70cf0a28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91365","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:ddecccea-de7c-4292-8948-af7ac54435bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8466","original_object":"UniProtKB:O14965"}
{"id":"43fbf091-5ed4-4e17-a3ed-d13340c32bd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137017382","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:ad67aed8-5897-41e1-b86b-b9e5df4efc54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12611","original_object":"UniProtKB:O95271"}
{"id":"891a7a1f-1efd-478f-856a-d07cfad01444","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5282428","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:a6e876d7-62b4-494a-84b7-b886f67ce811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1967","original_object":"UniProtKB:P43252"}
{"id":"1ea618a7-e922-4046-b0f4-a7f4c46f0089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17814","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:f688eb15-d9ab-4ac2-bd2b-f93b995d8f2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12454","original_object":"UniProtKB:Q9NYV7"}
{"id":"07157749-b26a-46a7-bd4f-a033badcab59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44630125","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:c8e57685-585a-478c-860b-073d5609cf07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4147","original_object":"UniProtKB:Q99572"}
{"id":"0a75bbda-ad2e-4d47-9815-7d97af9ac13c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9816778","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:f3861492-c4b9-4386-971f-1d21ef097935","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6398","original_object":"UniProtKB:P31424"}
{"id":"2db8525a-fec6-4b9b-8664-2555722f38b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5280374","predicate":"biolink:affects","object":"NCBIGene:18171","sources":[{"id":"urn:uuid:53cb6ac6-fad1-4428-8d0b-4b8158662fa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2771","original_object":"UniProtKB:O54915"}
{"id":"f5f4cfcc-92e9-4c7b-b77c-1081fd244848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124333","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:b4e0560b-0c63-4123-aa07-4ec98cdda330","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1729","original_object":"UniProtKB:P47900"}
{"id":"a5706da8-0ed8-4c79-8f16-85ef0ef46933","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111162","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:03dc1527-4d9d-414d-92f2-8114508bc9b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4219","original_object":"UniProtKB:P42261"}
{"id":"60281b4d-b71a-4468-b43c-ccc59f27a306","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15JL80DG6H","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:d864f9ac-c525-491b-bf18-a5c387cc492a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10658","original_object":"UniProtKB:P09619"}
{"id":"fa1739e4-aa72-44d0-8069-826d81587b38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35003","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:8c2873ae-ef37-4212-961e-51e919075842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4068","original_object":"UniProtKB:Q14957"}
{"id":"5ba351b0-c76c-4956-bd40-379a0ffe9438","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50122","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:f142a9d3-6981-4eef-a846-0199a01001bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1056","original_object":"UniProtKB:Q9HCF6"}
{"id":"8aebd362-ddeb-4979-a2a1-6c927837da30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79045","predicate":"biolink:affects","object":"NCBIGene:8879","sources":[{"id":"urn:uuid:86e4242b-7d34-490f-9a9b-d04caf2d04ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8465","original_object":"UniProtKB:O95470"}
{"id":"2d8122b3-4eff-457e-99ea-b9e4b76666f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56927659","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:a6350408-19fb-477d-b757-b573dec4a833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10114","original_object":"UniProtKB:P32745"}
{"id":"3daad58f-b174-46c6-88aa-85b6f27d8c7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129887154","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:f242540e-05c2-43d6-9a64-70bb308116aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2269","original_object":"UniProtKB:P41587"}
{"id":"6a97d84e-1c7b-47e3-a576-f5830700b3d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10659","predicate":"biolink:affects","object":"NCBIGene:3560","sources":[{"id":"urn:uuid:bf8faaff-a56d-496d-8c56-35c58feeb4dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10659","original_object":"UniProtKB:P14784"}
{"id":"9c13d5e0-db17-4305-8f55-18c0b845c92d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:4296","sources":[{"id":"urn:uuid:cb2d0e8c-ca50-4afb-b497-f21dabd6d740","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:Q16584"}
{"id":"2f8b3086-129d-4462-bcf2-f1d088fcfd24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124037380","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:3e3feabb-3160-4433-8ed8-ef4b286bc1a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9388","original_object":"UniProtKB:P43405"}
{"id":"42d31dda-5ea9-4e7d-ab66-28c9df8337db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6127","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:e179448e-1525-4b28-9d4e-1eebcc489733","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6127","original_object":"UniProtKB:O88626"}
{"id":"d1429529-6891-4e46-9d07-be0f7c7b8b00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZE94SP78UG","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:f824753c-01f8-49c7-8d20-a7fcd63df5e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13496","original_object":"UniProtKB:O14965"}
{"id":"d7866600-9c5f-469a-b52f-4d00f193a4f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50931","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:f71aee54-342f-4246-bfaf-30b333ff914a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11976","original_object":"UniProtKB:P14416"}
{"id":"5c0f0ecd-d75a-4441-af8a-b6250997b8f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:603","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:17158ede-224b-4133-831f-4fe843bd33fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:603","original_object":"UniProtKB:P35414"}
{"id":"1fcf5636-acea-4651-9273-0f47d546598a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104895","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:b3ed8794-9d02-49fe-850c-c5f92865cfd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:730","original_object":"UniProtKB:P21554"}
{"id":"c9eddf63-dcac-40e7-a351-7d0c37a9b4a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197431","predicate":"biolink:affects","object":"NCBIGene:29559","sources":[{"id":"urn:uuid:07d65a56-0b12-4891-82d2-507b0878162b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4185","original_object":"UniProtKB:P22756"}
{"id":"99a5851f-9b72-476c-bc7d-049503d6a390","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3741","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:c962b9a4-aa35-44c7-b5f3-0f2972fe9f8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3741","original_object":"UniProtKB:P55085"}
{"id":"dec23061-772b-4c3f-b23f-fd7565d38882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2381342","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:d84383f1-dec7-4075-bb85-f644fedf02a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9380","original_object":"UniProtKB:Q13164"}
{"id":"84190370-7587-49f1-a303-bbab9041b8e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755058","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:83f64907-79a3-48bb-8355-72bfcb445e39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3524","original_object":"UniProtKB:Q9GZQ4"}
{"id":"79a9007e-d5b4-4901-b209-9e7ccedbe08c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5779","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:7928c011-737f-4d42-bf8c-fccd336a882d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5779","original_object":"UniProtKB:P21730"}
{"id":"d84b129b-310b-4436-909a-93f7f4c2c1f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232381","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:e93176b8-28db-4f1f-ab54-24fd5a4a16e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9355","original_object":"UniProtKB:P45983"}
{"id":"86338e76-0377-4540-9f33-281709f96a90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:a3057c25-02f1-4258-b50e-2472ebff6d70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08173"}
{"id":"0b0218c4-dcde-422f-a3e7-61bbfe826bc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:6011","sources":[{"id":"urn:uuid:d6419d03-d6f3-4bf1-a1e0-1dbb5ad19e46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:Q15835"}
{"id":"8d52bcda-dee1-43f5-a824-4098dee33b10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91376","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:54d212ea-8521-4ad9-8d0d-eaeaed336043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8353","original_object":"UniProtKB:O14965"}
{"id":"04de5bec-4601-4f2c-8c80-3bd85d042e24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755255","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:46e80525-ddd1-4f70-85d0-6b97c4932eb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6993","original_object":"UniProtKB:Q9JL06"}
{"id":"96baeec4-d5db-4243-a47e-458648618757","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LKC0U3A8NJ","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:b4bf4075-6826-4b7e-9f99-874254734ef1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7343","original_object":"UniProtKB:Q8NBP7"}
{"id":"3ba27a4e-7706-4c76-86cb-a7faa113c8ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13441","predicate":"biolink:affects","object":"NCBIGene:116506","sources":[{"id":"urn:uuid:9e09dd40-001c-4590-9828-ce77d9819ac6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13441","original_object":"UniProtKB:P32214"}
{"id":"94e71893-515a-4fe6-bc66-0ae792093a37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10119","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:4473ffd2-f3d4-4edc-bdc6-94d51e25aecd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10119","original_object":"UniProtKB:Q9UQD0"}
{"id":"436e504b-f82b-4c43-9e6c-c3a33d37344a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89836339","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:2d819ff9-ade5-48de-8f3f-e85846a4ec4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9337","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"79454329-b50b-4959-8654-13c05229eaad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122227","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:03de61ec-77c3-4967-bb69-ef06f710a696","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:644","original_object":"UniProtKB:P32299"}
{"id":"6e797e1d-fdd2-4d23-a34d-57fd086f205a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448902","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:fa8d6cbe-ce10-4c01-856c-f84a4f361bb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12485","original_object":"UniProtKB:P22607"}
{"id":"bc1ba862-1658-48c3-988d-128e4a935e64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230488","predicate":"biolink:affects","object":"NCBIGene:3417","sources":[{"id":"urn:uuid:f9de0a80-ab6e-44b7-99eb-f38094ee35d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9240","original_object":"UniProtKB:O75874"}
{"id":"e5c124c9-c246-4285-bd63-36f04db22d91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:4c404919-8040-4d97-b237-1a7f297f3618","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:O15552"}
{"id":"1afe1691-85c0-4ec3-ba7e-ae179f72cf8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25060878","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:5bba2ea5-dbe4-4678-9934-6c3978bf07b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8125","original_object":"UniProtKB:Q16539"}
{"id":"c6ede1ec-be02-461c-817c-ec0f14d533a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103974","predicate":"biolink:affects","object":"NCBIGene:6572","sources":[{"id":"urn:uuid:37d13858-2261-421f-82a4-a26d3b1b0beb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4759","original_object":"UniProtKB:Q16572"}
{"id":"bfe6bc0d-dfa3-498a-bcc3-e8eb4648af1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:305EB53128","predicate":"biolink:affects","object":"NCBIGene:116085","sources":[{"id":"urn:uuid:5ea8415b-7b37-417d-9cd4-e678974e4258","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11389","original_object":"UniProtKB:Q96S37"}
{"id":"731a12cb-e0c4-45b2-abb1-8486fe36c1bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15428","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:8b0c4612-b488-4712-973b-c394ee0ca60a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:727","original_object":"UniProtKB:O15399"}
{"id":"39b58b82-82b6-4ec2-a098-57bf3fd03edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16681707","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:e73d420a-354e-4897-8976-b38a45a91bbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1767","original_object":"UniProtKB:Q9H244"}
{"id":"cd7474dd-5e73-41c7-a093-1961e66cdb14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2863","sources":[{"id":"urn:uuid:feac7ec6-9cb2-4324-9c36-79a44bca1623","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:O43194"}
{"id":"b73d1843-eaa9-4543-a61f-c260cabaaaad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11772958","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:1455331d-0937-4b5b-8191-fe231905c9e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5972","original_object":"UniProtKB:P36888"}
{"id":"64c8c72b-d61f-4f43-a21f-ca0cff89c287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18258","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:bde41ed2-17df-4e32-931a-27418a1058cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2634","original_object":"UniProtKB:P10827"}
{"id":"21a583c0-fe9a-4b51-9ee9-6ce5fb24f49d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:7182","sources":[{"id":"urn:uuid:23b1b2d3-9425-494f-b670-704c3e178b39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:P49116"}
{"id":"2a2d3d5c-6f31-4eca-b944-749fdb74a59d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90844","predicate":"biolink:affects","object":"NCBIGene:292661","sources":[{"id":"urn:uuid:4488b558-9825-4e42-8458-979718f2bb5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7552","original_object":"UniProtKB:P43253"}
{"id":"2a627158-5f65-4f55-906e-1cdfc0f09f24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R1XBQ6NTFR","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:86c92be6-2a13-4dac-b9c3-2156322b1bcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:154","original_object":"UniProtKB:P34969"}
{"id":"d3c35d74-5ebe-47f3-9743-1ced99c3df82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:3d56d5cf-f2f9-4e32-a581-f5eac906b55c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P50406"}
{"id":"9bb3f0f6-3c50-465b-9ade-8d40103ad88a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105957","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:dfd7b6c8-6566-4194-ae36-6c9b63f7e397","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10366","original_object":"UniProtKB:P51449"}
{"id":"4f8db783-d2e0-4202-a419-28ab2cb8ddbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2814","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:c577aebd-99a2-4b81-a5f7-96de151e5f17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:296","original_object":"UniProtKB:P08482"}
{"id":"64cb2727-0d68-46ce-9c7f-a692d349c4f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137213562","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:10f0ab15-9d55-4079-a8b7-41f8d69f1f3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10676","original_object":"UniProtKB:P09874"}
{"id":"82bcd3a4-b8bd-4ec6-8430-88ecd9d2fd58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15338746","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:139a9a37-b488-4a9f-9bff-8cf3075b97f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2591","original_object":"UniProtKB:P51787"}
{"id":"06cd7d7d-daf7-47c8-9170-3702aa3d803e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030530","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:f3e45210-7c77-4687-b025-e8fe59ec2d7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10481","original_object":"UniProtKB:Q08345"}
{"id":"d9e4cb14-da2f-4ab7-9e0c-3aaa1d6f9eed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4653","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:0079acd4-ec15-468a-b36f-43a32ca5432f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4807","original_object":"UniProtKB:Q7RTT9"}
{"id":"1d1ef2d9-c44c-4b02-9a9b-257a490a29ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3656","predicate":"biolink:affects","object":"NCBIGene:1236","sources":[{"id":"urn:uuid:9cf561bc-a1b7-4142-a1e9-b7bd452f7ca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3656","original_object":"UniProtKB:P32248"}
{"id":"2cdcc2d9-c99b-44c5-8318-a9a59d520a61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:92613","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:a767aabd-373f-4384-a992-a927c103db52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1268","original_object":"UniProtKB:Q9H3N8"}
{"id":"1950f99f-59d3-4458-8594-54ec308db402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1797","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:b63ed9ad-7018-4b18-89c1-cf7bb106da1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1797","original_object":"UniProtKB:P49190"}
{"id":"eeb56005-b559-4ec2-9da8-34d7c39903d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:eda8e318-a636-44e8-90cf-621ad6c98ca6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P28222"}
{"id":"1ede5812-c570-488a-b0af-7c577ad9ef5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:8e796102-086d-44f4-9b06-0bdda213247c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P43119"}
{"id":"80d8b5f2-c27b-485c-ae47-be711d0471e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2745583","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:fb22e9e4-3d4e-474c-98c4-469190b2159b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6404","original_object":"UniProtKB:Q8TDD5"}
{"id":"1809b87d-a2aa-41c4-adae-4463e69bcc58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:226","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:7e47b187-1a7b-4757-8cca-ab4896dd245b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:226","original_object":"UniProtKB:Q13639"}
{"id":"b800f0ff-d36d-463d-8f65-8a300efca677","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:25323","sources":[{"id":"urn:uuid:3d2bd667-0d68-41c1-8b4b-350959aafcdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P28565"}
{"id":"98832321-db77-45a8-9091-5a6dce3e2a2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73348907","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:0a79780a-5dd5-4d07-a581-612d545d0a67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8132","original_object":"UniProtKB:Q13153"}
{"id":"9b042e1e-f1ec-4c1a-9db2-54ba0d010e5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5276852","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:b654aff5-cfec-4b40-b1d4-61f73ec58349","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7507","original_object":"UniProtKB:Q92831"}
{"id":"728cda8a-683d-4862-b42e-be7f6c831649","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:341567f8-611a-4e98-89a1-09353986cdec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P09619"}
{"id":"1ddfaad7-5a2e-423a-a13d-eb7fc1ea1e6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2278","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:d3d9bd18-6602-44d9-9522-d185bb6cd56a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2278","original_object":"UniProtKB:P41586"}
{"id":"af12cbe6-e7db-4e26-9129-5cb1eac1cc41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:32D64VH037","predicate":"biolink:affects","object":"UniProtKB:P18901","sources":[{"id":"urn:uuid:36ca87b6-74e6-47de-898b-6493568708ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9267","original_object":"UniProtKB:P18901"}
{"id":"5c451fdb-6d2a-4ba4-a155-a21d976985a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827340","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:18021bdd-1a79-49ee-85ab-6a3ab3013863","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:527","original_object":"UniProtKB:P08913"}
{"id":"9e89f7d6-fccd-418c-85a9-2eee34293658","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:5d7ce6fb-32aa-4635-b754-60eba2cec2a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P48545"}
{"id":"5f285b4d-81b8-4288-9957-261bdaec69c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2271","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:a321b48c-81ef-46e6-8229-f890ed04f5bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2271","original_object":"UniProtKB:P30083"}
{"id":"a692ee39-b869-402d-b62e-adcffd7e20ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755205","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:0c0e3af9-5e0c-4b7d-b7d6-7f5e870c76bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6324","original_object":"UniProtKB:P31421"}
{"id":"d488fb76-40cc-414b-9369-0a74f760e655","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75593419","predicate":"biolink:affects","object":"NCBIGene:5045","sources":[{"id":"urn:uuid:e8ed9069-136c-4c5c-a61e-f7eeebe1e6c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8658","original_object":"UniProtKB:P09958"}
{"id":"250f4e44-e215-447c-9697-73830052b363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y76WZ464EY","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:20cc5f75-822d-4b97-ae7a-a06db3fd73a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11315","original_object":"UniProtKB:Q92633"}
{"id":"5df86f96-9264-4148-884d-92c74eb6cb07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13872","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:8d9bc3c3-3860-4cca-9604-9a30d6bc4dfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13872","original_object":"UniProtKB:O60885"}
{"id":"155b5abf-aa5c-4d1a-b59e-562aa03d5576","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6114","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:8fea1d43-2c33-46ec-9d98-22309b07c1b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6114","original_object":"UniProtKB:O43603"}
{"id":"ec76bb80-dcf4-4a8a-ab64-36b98399cba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86268622","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:68c15247-03fe-41a2-b19f-e5de4d3edd33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10163","original_object":"UniProtKB:O00329"}
{"id":"07225afb-a20e-480f-9765-4f202374c5f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15578","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:8be76c14-630f-46b0-b60f-f42be859e611","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13593","original_object":"UniProtKB:Q9NPD5"}
{"id":"4caee0a3-67f4-4a37-960c-031c8aa18f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:84050","predicate":"biolink:affects","object":"NCBIGene:18171","sources":[{"id":"urn:uuid:21945b34-5362-416d-a69b-78e36ec66980","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2774","original_object":"UniProtKB:O54915"}
{"id":"535c86a0-33b4-4d82-91f5-7918f7d866dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8746","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:43119497-b959-46cc-a527-bdbd98bc68ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9816","original_object":"UniProtKB:P08588"}
{"id":"8911303d-fe45-452b-8884-a25127637082","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:e9fd54cb-4deb-4043-b266-bc71fcad2a7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2491","original_object":"UniProtKB:P22460"}
{"id":"617cba08-d5f3-46e8-8f45-a8db713da978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:158617","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:69af1510-be61-4099-afd6-bfe7076d3494","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2733","original_object":"UniProtKB:Q13936"}
{"id":"6da86ef7-1a35-45ee-8e89-2b5a7346bd14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:ca5aaa1f-4bf2-482b-800a-c07987748a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P18089"}
{"id":"d27fa405-bd01-47a2-acdd-f936b4f6adb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92593","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:3f894abe-2556-42de-9cb9-1deb5bdb9715","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4346","original_object":"UniProtKB:P31644"}
{"id":"706a69c2-42d9-4b12-9f18-3545524371c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QEN1X95CIX","predicate":"biolink:affects","object":"NCBIGene:1493","sources":[{"id":"urn:uuid:c6001b7f-c0a7-4c24-a55c-e0bbbd197e4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8462","original_object":"UniProtKB:P16410"}
{"id":"742d13d8-e343-4847-8346-b1002918ee1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030533","predicate":"biolink:affects","object":"NCBIGene:2516","sources":[{"id":"urn:uuid:ae38a1de-fc5b-4d94-90c4-a4c2f65cb679","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10484","original_object":"UniProtKB:Q13285"}
{"id":"2506f5db-b9ca-47c2-93ca-4e47cf6428ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:7048566","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:da03af27-0833-412c-bd82-da0fe8b8274a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:137","original_object":"UniProtKB:P28221"}
{"id":"b32af946-fbda-412f-9e18-bd75c6273252","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9811445","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:dd12c2c5-0603-4de5-9ace-26419290d0d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2321","original_object":"UniProtKB:P70604"}
{"id":"8fec51c2-f8aa-4440-8278-c3d0db44bfc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118308152","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:fe6ccec6-0012-4db1-a6e2-fb68ec3cc8d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12604","original_object":"UniProtKB:O43614"}
{"id":"e80af963-a517-44ff-b784-0de6198ad597","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755075","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:eca1a075-752c-4384-b4bd-c68cd420820b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4046","original_object":"UniProtKB:Q96G91"}
{"id":"e7f90a5d-1934-4e68-ae7b-69a316149783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64210","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:6eec0e2f-b6cb-4ddd-ad4e-ac8b70a5daaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2647","original_object":"UniProtKB:P13631"}
{"id":"b4e3247a-b45c-401a-8351-fde0a1db6d80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2574","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:2668aa02-c4b1-4dd7-a5c2-75627a09769d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2574","original_object":"UniProtKB:Q14524"}
{"id":"e5927431-b75a-411b-9ff1-115b3260b70e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:5320","sources":[{"id":"urn:uuid:6425deaa-7ddc-4fa0-bdd2-8eb34b03d32b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:P14555"}
{"id":"b4cc8caa-52a0-4f49-93ab-f2ea589764e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8V3VQ6HMII","predicate":"biolink:affects","object":"NCBIGene:25413","sources":[{"id":"urn:uuid:e703d5da-046a-4de6-ba36-e0830d4f5bbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12976","original_object":"UniProtKB:P18886"}
{"id":"72666802-cbaf-4ea7-aa71-7f40db877cc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2532","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:42baa2f4-ce36-4614-b8d5-5ebb81db5207","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2532","original_object":"UniProtKB:P54282"}
{"id":"26199409-0ed3-46e0-a8d1-58c016645a37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3559","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:d641208a-d362-41de-9a8c-e048fd1faa91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3559","original_object":"UniProtKB:P56481"}
{"id":"60a53f5b-da01-4574-94a3-271cf121d35c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368930","predicate":"biolink:affects","object":"NCBIGene:5609","sources":[{"id":"urn:uuid:633dd54d-ab42-4cfd-ac05-ed6cdb07cccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12104","original_object":"UniProtKB:O14733"}
{"id":"cd44417d-378d-46ef-8430-1daf42846147","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13882","predicate":"biolink:affects","object":"NCBIGene:1510","sources":[{"id":"urn:uuid:2b9a6546-6c20-4e28-835a-624c17e2067f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13882","original_object":"UniProtKB:P14091"}
{"id":"d123d870-11c0-483b-bdd4-fcff99e9a6bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"UniProtKB:O54898","sources":[{"id":"urn:uuid:6d803f11-fbf5-47a8-9609-2cbaa358cbcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:O54898"}
{"id":"b551ae05-4581-41dc-b84f-71fa178490b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889227","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:70b7904e-5e81-4945-ba9e-c008c6b3b59d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3058","original_object":"UniProtKB:Q02769"}
{"id":"b7f9a375-fc5a-4dca-9bdc-8278351119d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11625520","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:d9a84fc1-cd30-4771-9acf-cf2b1cb2dd5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4059","original_object":"UniProtKB:P31424"}
{"id":"0b9a7d76-f085-4c65-933f-8070d6eaade1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7686S50JAH","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:04a81142-58cb-4441-a942-665e3f7fa7ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7443","original_object":"UniProtKB:P05129"}
{"id":"43ca7d2c-e967-4690-8665-50970c007441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122163152","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:f7654f9b-c5c9-4794-8629-4664f288c1fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9571","original_object":"UniProtKB:P42336"}
{"id":"db492cef-3812-41f7-b9c4-734170bc729e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13947","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:52d4f3fb-e5be-432f-9ba6-3718f9477612","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13947","original_object":"UniProtKB:Q9GZQ6"}
{"id":"fec88f8b-3d5a-4351-b88b-fa41a08ed637","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:68befc9f-a963-41a6-9663-308beba20f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:Q91ZY2"}
{"id":"78e8232f-9de4-4e6f-b492-0035b01a112b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:00LOF6890B","predicate":"biolink:affects","object":"NCBIGene:5340","sources":[{"id":"urn:uuid:e07e6437-7f06-4ddc-a48c-ead724c5f9fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6498","original_object":"UniProtKB:P00747"}
{"id":"1e116580-d688-44ad-9e85-3ad5ed721480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3638","predicate":"biolink:affects","object":"NCBIGene:50831","sources":[{"id":"urn:uuid:0ad3277a-2549-4f14-afb0-482b9dc84032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5535","original_object":"UniProtKB:Q9NYW6"}
{"id":"1d1145cd-187f-4595-8723-f1f88d51729f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:83b0c6a2-c625-4704-aa84-e2cf33ba053b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9H2S1"}
{"id":"c8d2c444-f54f-4a67-9599-ac3e8fbc63d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8412","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:e47c71de-6a06-4732-9831-f454a4a4e7d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:5338","original_object":"UniProtKB:Q9HCF6"}
{"id":"141118c6-bb46-4b51-b94e-f075048e6bdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:94ad820b-86da-486a-890d-89e082240394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P43115"}
{"id":"34575d8f-c7ab-4219-8bd1-9fe29e6a90fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1HXF46Y439","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:9d3d3f22-4998-4dc1-a8ca-d375a4684c4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:877","original_object":"UniProtKB:P32238"}
{"id":"d9f98854-4e9c-4654-8112-e77bb2c5d901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FQK825B5DX","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:5cd78c1e-da05-4435-bb11-b4b38db2a5b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8862","original_object":"UniProtKB:P22607"}
{"id":"521be755-96df-4ad4-9365-bb90b2d5c65a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:0c58f958-17d2-4b54-af77-fcc936e75ea5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q9HCX4"}
{"id":"4954b641-c45b-4d1b-88e8-08db6d0f617f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4374","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:b4b5be96-86b8-4c6c-9b05-b17e2de10842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4374","original_object":"UniProtKB:Q8TDU9"}
{"id":"3d1c7792-18ed-4ad5-a5e7-437315e46ad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63451","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:0080dc63-cd89-44cc-a991-d3f03832bb37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7877","original_object":"UniProtKB:P22455"}
{"id":"5c1cef44-4f38-4f42-b3a7-610e31d727b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:25555","sources":[{"id":"urn:uuid:dbc086e8-9c0b-4cc8-a051-7f2465b5c4fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P30937"}
{"id":"a36bd234-3f29-49e7-bb21-e6338df6acbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9249","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:355d0d55-73c8-456b-a010-b00eedecb6d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10369","original_object":"UniProtKB:P03372"}
{"id":"172b4284-cb63-4dbf-a723-6afef27eb23f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16363","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:269bedf7-78d2-439e-99c9-b6ec55b1b2fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12448","original_object":"UniProtKB:Q9NYV8"}
{"id":"8426713f-e66c-47a9-b07a-82692ebeec55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z80293URPV","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:f28e28bc-d343-486c-a6c0-c59256ab9a62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8709","original_object":"UniProtKB:O95136"}
{"id":"a12d7927-c2d3-4a66-951a-08956347ff4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8535","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:ea631ed9-9865-47cb-a199-45b2d59063e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8535","original_object":"UniProtKB:P61073"}
{"id":"a573f637-5f74-46a3-bf77-b57ee7528a6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59751","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:8b75c107-3ee4-4d11-8a98-e66ab3dba564","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:878","original_object":"UniProtKB:P30551"}
{"id":"a2109499-047f-49e9-a1d6-4ba6fc429097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44256277","predicate":"biolink:affects","object":"NCBIGene:156","sources":[{"id":"urn:uuid:79716dca-db9b-4ed4-8da3-8abc7c608a8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8143","original_object":"UniProtKB:P25098"}
{"id":"49ca0008-b748-42e5-a06b-9bfa5406b5fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8430","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:36f2baa0-4c50-4bd1-811f-85147918e80d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4291","original_object":"UniProtKB:P21817"}
{"id":"a6ce667b-8a97-4533-9e88-51850cf9e1ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11530","predicate":"biolink:affects","object":"NCBIGene:30816","sources":[{"id":"urn:uuid:16e37dcf-f0b0-4f1f-9537-0da38f9ac44c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11530","original_object":"UniProtKB:Q9UQF0"}
{"id":"8d49ea95-1a69-4fc1-8b34-07e2ce4950cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6T4O391P5Y","predicate":"biolink:affects","object":"NCBIGene:91","sources":[{"id":"urn:uuid:75e578e8-a165-440f-8d41-556e994c7ece","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8107","original_object":"UniProtKB:P36896"}
{"id":"74056afb-d479-4169-b2c8-0a3cacde9ab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125467","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:012e854a-1448-47b2-aa75-be94556bcf0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1265","original_object":"UniProtKB:Q9QYN8"}
{"id":"4d6a3e7f-e8fe-4bfb-89e4-f39d3b7baf62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:37a9214c-7faa-4db5-be04-3ae8f36112e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:Q60614"}
{"id":"d3ee5699-d0f5-466d-a511-217b2a76f097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Q7I1WL2UY","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:9322ff7e-4785-47f0-a24f-81d31afc9a70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:20","original_object":"UniProtKB:P30939"}
{"id":"435993e4-e4d1-4f3d-81bb-d7746734c87b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13113","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:8193b817-81cf-4142-9a05-21b18f1facae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13113","original_object":"UniProtKB:Q9UBN7"}
{"id":"d5009e11-ec0a-4f02-bf60-03ae536f1eaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:89649","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:f9446807-9346-42f4-ab92-290d6f302f85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2295","original_object":"UniProtKB:P23979"}
{"id":"2305dea1-ec21-4bb6-9b81-facb132291b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6U9WP10T7","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:35057710-4f3b-4749-8b10-c119790383a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7885","original_object":"UniProtKB:P16234"}
{"id":"a7416ccc-2c6b-4d08-a928-da567a9276b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11601743","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:7b783a4e-7c0f-4bfb-bcd7-12881c977e33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5971","original_object":"UniProtKB:P36888"}
{"id":"915a8842-f43b-4475-8b49-7922ba2fd174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13293","predicate":"biolink:affects","object":"NCBIGene:8795","sources":[{"id":"urn:uuid:06831aef-1a13-45a0-a9d3-be8ea5dd154d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13293","original_object":"UniProtKB:O14763"}
{"id":"16df0875-1427-4d7c-a133-d7a431abb3b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:7ed743d7-b3f2-4844-a8bb-0f95c2430c9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P28221"}
{"id":"95925752-5c52-45de-b201-780afc2bca87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63621","predicate":"biolink:affects","object":"NCBIGene:79882","sources":[{"id":"urn:uuid:6fab42a3-ac6e-4c98-87fc-a72ca400a67a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4813","original_object":"UniProtKB:Q6PJT7"}
{"id":"bd2a0791-332b-4d53-9431-4f641e6e5352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142077","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:8d72856b-99ca-47fe-832a-384905ccd0ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9326","original_object":"UniProtKB:P08588"}
{"id":"bd2e525e-6c46-403d-90fe-b22fd25727de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195398","predicate":"biolink:affects","object":"NCBIGene:4312","sources":[{"id":"urn:uuid:9476d73d-f05e-48ed-9ae6-2a9274d36a47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5145","original_object":"UniProtKB:P03956"}
{"id":"60196129-365a-4010-bca8-5b78bcf78aff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5636","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:b76b319e-62e3-4853-b707-143f8bfe982c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5636","original_object":"UniProtKB:P30874"}
{"id":"ee50c88e-5c93-426a-925a-d50e184ff1f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:96f16c43-6935-428f-9f0a-5c6ea6fb7cf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P30542"}
{"id":"5d8426ba-e0c7-4684-b5d5-3d214958d056","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122707120","predicate":"biolink:affects","object":"NCBIGene:7941","sources":[{"id":"urn:uuid:de5b8ee1-ec01-427e-971f-f0b271e875cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9796","original_object":"UniProtKB:Q13093"}
{"id":"2f948484-276c-43a4-8e98-696f0d7c60cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44571034","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:4a72db2b-6b6f-4206-ab1b-8b84e7bd05c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7036","original_object":"UniProtKB:Q92831"}
{"id":"ed2c663b-043e-4138-a8fa-13cb1a9866ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14343211","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:8eec744e-d072-41ba-84c4-80bf624b0217","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1419","original_object":"UniProtKB:P31424"}
{"id":"237348a4-d3d1-4f82-914d-4203994b55ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440220","predicate":"biolink:affects","object":"NCBIGene:2846","sources":[{"id":"urn:uuid:7aa7c736-27ae-45f5-a408-e23799ba5b6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2911","original_object":"UniProtKB:Q99677"}
{"id":"651838d0-f22d-4fec-883c-64292910d86a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5VWV92039E","predicate":"biolink:affects","object":"NCBIGene:2103","sources":[{"id":"urn:uuid:15871006-b6d5-4c54-bbb7-669df9c2f844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2834","original_object":"UniProtKB:O95718"}
{"id":"e3adca3e-055a-4fe3-8b1f-2b3e2adfc0d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:e4f807d1-ea74-4e08-a0c6-d295c8b67626","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:P31644"}
{"id":"348476a4-5a64-4663-8145-0343b3c10cf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:ab6ab101-2838-44b7-8448-a4efbf8f6672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:O15303"}
{"id":"1f9fb09b-74db-4ad9-8cac-080990fd9b29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182322","predicate":"biolink:affects","object":"NCBIGene:5476","sources":[{"id":"urn:uuid:a3841b47-af06-4206-9e4d-963758ef22aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7891","original_object":"UniProtKB:P10619"}
{"id":"779cdc9b-7f62-424f-98b2-ed773d759bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:3c14a0c1-ef06-4dc4-be96-701e88cd5845","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P35000"}
{"id":"bab8640f-da06-4ceb-ab11-89f3e4e7673f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5615","predicate":"biolink:affects","object":"NCBIGene:56660","sources":[{"id":"urn:uuid:50539e8a-f953-49ac-b336-5a7eecde9c6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2401","original_object":"UniProtKB:Q9HB15"}
{"id":"f8ecdc36-9ce9-4561-ab35-b781e9eade2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49783923","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:e3ab4cec-42c0-4943-8c67-59d48020bf3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10633","original_object":"UniProtKB:O00329"}
{"id":"d8b67bfb-11e1-40c0-be7b-582f67fe7768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135949","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:77f71146-cb80-4dda-987c-2141cca21222","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3951","original_object":"UniProtKB:P25101"}
{"id":"5226d144-2797-41b6-9d3f-fe206a6b2b24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139299","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:d5551ca4-1d7a-4444-8213-fdcab45dc2f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2500","original_object":"UniProtKB:Q9HBA0"}
{"id":"1eb34a05-1c44-478e-b21e-6706c8855dd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9137","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:d91050b7-422f-4795-a808-876f1f131cb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2586","original_object":"UniProtKB:P23975"}
{"id":"e178a465-98b5-47ad-80a0-865092c7cd3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:5014e70f-edf0-44a1-ac78-9f20587e8238","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P08912"}
{"id":"afe4bc9b-bdea-462a-a988-0d798fefa510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2099","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:758f6b35-f29b-44f4-af36-cc24b677046c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2099","original_object":"UniProtKB:P25103"}
{"id":"03b446f7-e4b9-4af7-9dea-e835a1696c1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16108961","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:83455cbc-21ba-4950-9e94-b347bbdbebbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:664","original_object":"UniProtKB:P97583"}
{"id":"4947fd05-b470-48a4-93e6-e15ea8aac4b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:1fd3740c-4787-4c14-9871-22813fe2d1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"078bc522-8db8-464a-a18d-9e194a4ada17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127042386","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:ed6aa096-3699-4429-822d-6cd28520d676","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10447","original_object":"UniProtKB:Q12809"}
{"id":"c2907ce6-37e0-41fd-bd0d-a778256af65f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41872","predicate":"biolink:affects","object":"NCBIGene:1259","sources":[{"id":"urn:uuid:f1aa3c51-1bce-41a8-b11b-f25efd18f216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2313","original_object":"UniProtKB:P29973"}
{"id":"9a4715a7-bf1c-459c-80fa-4b88228fe290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35056","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:81f9ce09-e9f0-445b-b4af-3a67603d60b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4093","original_object":"UniProtKB:Q99571"}
{"id":"05652470-96bf-49fa-8314-ca0a58928e37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311268","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:09b5b497-f6ad-4783-b7da-32c0c5a16007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6118","original_object":"UniProtKB:P47211"}
{"id":"744b1d0f-cbcd-4bb3-920c-e8cb6bd87d07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230958","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:82ee47f8-5bf8-4c62-881e-510714b776f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6894","original_object":"UniProtKB:P30556"}
{"id":"964e12b1-1e81-47ca-9bdf-e51559fbb4f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42519285","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:eeff6487-ccb5-4020-8f3d-517fb60415f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8591","original_object":"UniProtKB:P08172"}
{"id":"018b52e3-0e0c-41cd-9643-c9a54a14da19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51346799","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:328b85da-789a-4495-af19-deefa2285b24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6422","original_object":"UniProtKB:P31424"}
{"id":"be8d9cf3-9676-45eb-9236-1b2da39b9c0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H0EVX3PS4B","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:3485e642-6b3f-495e-9721-7627117224e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:174","original_object":"UniProtKB:P28223"}
{"id":"58e708a1-4569-43b1-97f3-ffcd28ffdca3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:079ea501-825f-4757-86f8-2259a2ee2e5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P41595"}
{"id":"1a3050f4-130c-4f40-9a3d-996c2f3e9394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:6068a493-a272-4dc1-bb60-009548a3b175","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P30994"}
{"id":"c932ac32-0778-4722-b8b0-e670280e090a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4283353","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:fb198ea9-3968-44ca-b672-39933ddc882e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10131","original_object":"UniProtKB:Q12866"}
{"id":"e00b7ad2-6748-424a-aa1c-5fc4a0c3d019","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13878025","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:5c591032-b912-4a3f-b74b-ec30078b5d6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:184","original_object":"UniProtKB:P28223"}
{"id":"f329a787-7c31-4861-beaa-f71991f80b28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1791","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:d260ac1e-11c9-4a49-8e3f-655facdfcbe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1791","original_object":"UniProtKB:Q03431"}
{"id":"a59a5d3b-4f70-4b7d-867e-75a4799b629f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5862","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:dfcdfc24-4832-44c1-9ca2-6f44fa217232","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12575","original_object":"UniProtKB:P08913"}
{"id":"3dbb9595-e57f-4816-b2aa-052412b6760f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34543","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:260fdb20-7040-43ee-91cb-c25332288c3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2168","original_object":"UniProtKB:P30560"}
{"id":"dfc9aec9-2d83-4a19-903a-274837de042c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71415","predicate":"biolink:affects","object":"NCBIGene:25874","sources":[{"id":"urn:uuid:dbb45885-cdb3-4974-a094-664355de8c2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10917","original_object":"UniProtKB:O95563"}
{"id":"5d282c7a-2bb5-4212-a0de-2166710edce9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6888","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:0386beed-7d86-45ac-933a-621889fd78b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7088","original_object":"UniProtKB:Q9UL62"}
{"id":"77b14766-537b-4016-8222-e7b2d27315e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5172896","predicate":"biolink:affects","object":"NCBIGene:12494","sources":[{"id":"urn:uuid:4db41a8d-feca-4604-a422-c52ee613ea9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12111","original_object":"UniProtKB:Q4FJL8"}
{"id":"8f65a9c1-326e-4ee2-9324-c34ffd13ecc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135125140","predicate":"biolink:affects","object":"NCBIGene:3417","sources":[{"id":"urn:uuid:f3964550-71b2-498a-92ca-f8d69279fe18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12340","original_object":"UniProtKB:O75874"}
{"id":"5e569b07-979f-4b76-b7e2-bc4c1b487194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43966","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:dcdfcc6d-161e-401f-a4cc-4409539aab56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6382","original_object":"UniProtKB:P00734"}
{"id":"6f653a61-7670-48d9-b4fe-2bb56d5ed5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996538","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:9c71cab2-caa4-47c2-bacc-1064468e2037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10672","original_object":"UniProtKB:O95271"}
{"id":"e22fc964-fc4d-4da3-977c-63b04acc4329","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177658","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:fd318d08-df2c-4b35-a231-151acdff7624","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11942","original_object":"UniProtKB:P14867"}
{"id":"2e3194d5-378c-48d8-8514-e6f08d0c9c8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11291932","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:e1730d3f-3868-4fba-9285-a3efb26e7cf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13125","original_object":"UniProtKB:P09874"}
{"id":"a22a4cff-d873-4b22-8648-359a1a8b4fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11393719","predicate":"biolink:affects","object":"NCBIGene:9252","sources":[{"id":"urn:uuid:bea9696b-3453-4047-884f-7f820d109d3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8130","original_object":"UniProtKB:O75582"}
{"id":"65922cf4-6ea7-4240-91d6-a8743bf8825b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N0A21N6RAU","predicate":"biolink:affects","object":"NCBIGene:659","sources":[{"id":"urn:uuid:39ba177e-c1a0-4209-9212-9b8739d22807","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10432","original_object":"UniProtKB:Q13873"}
{"id":"2b978a1c-84f2-42e3-b6a3-46a29863d555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11464","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:76a44d30-3146-4a9d-bbc6-c7341c67caaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11464","original_object":"UniProtKB:Q9HBX9"}
{"id":"f8786fc7-3f5c-4ce1-bdc1-15ea909e4146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:fd002273-eed4-495b-b867-52cee36a3110","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2486","original_object":"UniProtKB:P13569"}
{"id":"81d8c3f6-18dd-480c-8e18-d4abb99a8b5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6620134","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:17a3a8cb-6888-4243-bda6-0e4eae5541cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8978","original_object":"UniProtKB:P48736"}
{"id":"0ceeac65-faf4-4bcb-bf0e-060f77c8ad62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:20854918","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:5ca22d31-464f-44da-906a-a80a71d4ae6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8731","original_object":"UniProtKB:P09874"}
{"id":"b1f42ff3-139a-4a9c-b05d-9e816d7aafdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108247","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:3056a3c4-6c24-4db1-9f08-4e990bbb50ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3075","original_object":"UniProtKB:Q02769"}
{"id":"08f35fdb-a79c-4f7a-b185-ff6ba450ca8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64019","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:a12fc6ee-17ed-4df2-a7a8-f799f34205ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7246","original_object":"UniProtKB:P13945"}
{"id":"1a69f351-ec97-4442-a37c-5024345d59a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11677079","predicate":"biolink:affects","object":"NCBIGene:156","sources":[{"id":"urn:uuid:ba759de1-830e-4c43-bfa1-f092e589d565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8437","original_object":"UniProtKB:P25098"}
{"id":"ae4f5f48-d20a-4981-aca6-328bef191026","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135351","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:46779fff-528e-4ace-8b59-fc4c6331a296","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:941","original_object":"UniProtKB:P35462"}
{"id":"4311e070-fe91-4193-b19e-cd14e8fc4a14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68584","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:d07cdb8c-ac7e-431f-a943-1ffcef7fd640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2601","original_object":"UniProtKB:O43526"}
{"id":"5957240b-37ac-4ec3-8868-f94aa0ca6c4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93015","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:db72233f-6fc8-4121-ae68-7d96225d8434","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3274","original_object":"UniProtKB:P08173"}
{"id":"24e79e0f-2f73-4068-8fd6-75700232f779","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9334","predicate":"biolink:affects","object":"NCBIGene:8795","sources":[{"id":"urn:uuid:6de4ebbe-6b24-4352-8083-212380016e94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"antibody_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9334","original_object":"UniProtKB:O14763"}
{"id":"afc5d720-a4c2-41d7-a375-00c17172b4c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755182","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:8612019f-8af3-4942-8b1a-7e6a92f1bed7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6187","original_object":"UniProtKB:P35414"}
{"id":"3a3bd037-52e5-426f-81f8-ff3bdeaa1037","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8207","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:30461b3f-6073-48ea-8b92-877b2fe9302b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:305","original_object":"UniProtKB:P20309"}
{"id":"aa06c965-d9c2-40ab-b579-8b3c51e103d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:ad950c03-8305-4fb1-a171-e8a86ea6b70a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P48169"}
{"id":"daa1a799-4734-4fcc-8453-260fe8e6e9cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9NKZ9LYZ06","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:ff51c6c7-7acd-4d5f-8fa1-45ad1c1d8b50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9066","original_object":"UniProtKB:P20594"}
{"id":"e373a81b-6373-4563-8a44-804c2d6fb874","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75984","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:265d0e11-60f7-48d3-8528-caccda1b92bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2560","original_object":"UniProtKB:P63142"}
{"id":"3ea79dee-d789-4ea3-8f63-5306158abab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:6bb645dc-a99d-4f9f-87f8-e9eb88d5674e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:O43603"}
{"id":"548aa850-3b86-45c8-93ab-97f398c53e7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:03b02937-082a-4a4a-99d9-7218627b6ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:P47869"}
{"id":"bf597184-de7d-4fe3-bcec-8f1ce0fa8b0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3855","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:6f8952a2-6dbe-4ff2-936b-c3e6844e9631","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3855","original_object":"UniProtKB:P48145"}
{"id":"48ad0776-f834-4fd0-81d1-66e2eb13fcff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755260","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:723c71f0-f4ba-42e0-bc08-29641ed49e23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7375","original_object":"UniProtKB:Q96KQ7"}
{"id":"a10ce4c8-3d44-4acf-a7e1-2d6bc62bc7f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3646","predicate":"biolink:affects","object":"NCBIGene:2826","sources":[{"id":"urn:uuid:0e0d0ae4-6acc-404c-831b-bc9d4264623f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3646","original_object":"UniProtKB:P46092"}
{"id":"b8f550a9-c990-44f4-bbe9-dae8d1e5c551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141522","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:2853dc6f-5dbe-40c2-936c-68efb8ffa8d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6576","original_object":"UniProtKB:P12821"}
{"id":"2954c181-d422-481c-9ecf-c5b888ea0fc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47381","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:e259ad0f-e4bc-4d9d-9191-f31d8cadb58b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2714","original_object":"UniProtKB:P23219"}
{"id":"cf10017b-49b4-423f-9eee-79902774c0ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925850","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:5e2e9882-225a-4581-8f4e-bc22c4012c29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11565","original_object":"UniProtKB:P36888"}
{"id":"106f4efd-b318-4168-85d5-12b6c462feff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O812716S9E","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:1d40522b-4b29-4c70-b7d8-9d2f38c82abb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9306","original_object":"UniProtKB:P56719"}
{"id":"0c65840f-3b82-4b89-8769-c59b175f198c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:6c3a6fb2-dc1a-4705-8837-be9cc8f2e91f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P34995"}
{"id":"92ff115b-e956-4c0a-bd77-2dfeeb928502","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16584","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:5e2d96f8-daf8-4d52-b518-72140a0e7bd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3048","original_object":"UniProtKB:Q03426"}
{"id":"30e9db29-07dd-4ccf-bee9-b7f925997c03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46930997","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:b9c54942-44a8-42dd-9c00-26d201febfb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11086","original_object":"UniProtKB:Q07817"}
{"id":"a5142647-3d7b-49f7-be87-98f14b146dab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37537","predicate":"biolink:affects","object":"NCBIGene:343450","sources":[{"id":"urn:uuid:078a7697-a4f8-4a59-b4d8-31c40a9bde8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2341","original_object":"UniProtKB:Q6UVM3"}
{"id":"f8766a1c-f06d-4543-a0a5-1e036b04ff80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117951478","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:d16e399b-7fdd-4f31-9366-cad0399a0674","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9607","original_object":"UniProtKB:P34972"}
{"id":"cb002c62-445b-4227-ad88-d941a4c59181","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132369","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:00181891-2e01-4b3a-80b8-acbde480773d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2280","original_object":"UniProtKB:P41587"}
{"id":"5e7e6151-e2fb-4b84-ac21-ba6b0c133de6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:29731","sources":[{"id":"urn:uuid:6a2a47fa-62e0-4304-a072-e381a2278ef6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:P15384"}
{"id":"671ca4f9-2921-4784-92c9-dc1916982269","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3JB47N2Q2P","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:e22e7d66-9694-41f1-8d35-ec6bc09b90c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6591","original_object":"UniProtKB:P13612"}
{"id":"a9e1d3f5-4438-48f3-9368-a2646e10e0c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:54218342-27d2-42c3-be7a-67842e55c410","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P35462"}
{"id":"d79e2d0e-f261-47da-b944-ce5b3b687a0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51035721","predicate":"biolink:affects","object":"NCBIGene:1536","sources":[{"id":"urn:uuid:115bf6b0-6bd3-4ed0-886c-927ff2c1a02e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9931","original_object":"UniProtKB:P04839"}
{"id":"933c7df5-faca-4d4e-97d5-2200d171918c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCG5PW623C","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:61526724-3d76-4fd1-bd2e-6343326632a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10170","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"7e1e4ad9-31df-4154-96c8-1e1ce5899fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:765","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:7fb7e0fd-6b3a-4150-a3e0-42bbdd8b307c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:765","original_object":"UniProtKB:P32246"}
{"id":"a4e22ed7-c161-41f5-b1b7-b6f586f10743","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:1be3f7d7-2912-4553-be6f-62a3542bd0b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P70597"}
{"id":"2f2a1ca9-49ab-452c-9493-8b08412c0e5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433296","predicate":"biolink:affects","object":"NCBIGene:124976","sources":[{"id":"urn:uuid:1a6eec3e-c1ed-4388-b511-96cf6a95564a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12696","original_object":"UniProtKB:Q8IVW8"}
{"id":"0ee1de3a-2993-4283-b82c-6a5e45ae7b1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:4ce79e10-c8e1-4778-8d86-f59bea5148a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P09619"}
{"id":"6ffa089b-396f-4e15-95ac-789ac1a237bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:67b32d57-fc91-4e7b-a132-ed39e07040aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:P30872"}
{"id":"a2065692-c225-4435-869f-83be3504f328","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134824567","predicate":"biolink:affects","object":"NCBIGene:83567","sources":[{"id":"urn:uuid:61779567-1290-4837-acdb-d374efb1c061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1301","original_object":"UniProtKB:P97639"}
{"id":"b26cfce2-4796-46ef-91b3-8fc14f1f60bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:8d9b4c2c-23f3-44fe-80aa-ce7bfe786395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:Q00535"}
{"id":"def0bee1-a566-4646-af66-2a71f90b9709","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156087292","predicate":"biolink:affects","object":"NCBIGene:604","sources":[{"id":"urn:uuid:b2ad763b-6ef2-47f3-a874-54d041e2ef4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12414","original_object":"UniProtKB:P41182"}
{"id":"ecbf7460-37bb-4885-b34c-862951830937","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:543K8ZN6LH","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:7ba55e56-cea0-443f-bc36-36a80329f0a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8009","original_object":"UniProtKB:P31751"}
{"id":"e184939d-3fc6-4935-8069-a277b664db0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5348723","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:55960149-2926-44f0-90c5-8e32df3cc4ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12363","original_object":"UniProtKB:Q6DWJ6"}
{"id":"5b489e22-8aa5-4e76-a7b3-55638a56c8e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:f409eb9e-e494-46af-9003-fffd5ae90d38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P31391"}
{"id":"2b234784-2edd-4a00-81e4-1d9f77d5ecf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27693","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:ef7ac221-aa37-4d1e-b2fa-f0933586e79f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13860","original_object":"UniProtKB:Q96RI1"}
{"id":"40b34657-17d4-40d5-a7cb-1d925b3e7b23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182080","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:010ba677-79be-4b36-bd88-f2d813171c7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1606","original_object":"UniProtKB:P35372"}
{"id":"242b8b8b-7702-4e61-b31f-ef7f2d69a7fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1529","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:5092a42f-f586-48d6-a8e7-af57660eb2dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1529","original_object":"UniProtKB:Q63447"}
{"id":"189def57-f48c-4576-b8fc-0b51ddc696cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6538","predicate":"biolink:affects","object":"NCBIGene:55117","sources":[{"id":"urn:uuid:f7682229-9c7d-42d8-9f6d-1f0d3c6c3cc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7216","original_object":"UniProtKB:Q9H2J7"}
{"id":"8e7965cf-29a8-48c7-b130-1e03f128dc43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3900","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:0eb8391b-ccaa-4aa8-a74f-0ac13821a1ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3900","original_object":"UniProtKB:P47211"}
{"id":"4063c60a-00b4-47da-b9c1-1a67c9e7bbc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156304705","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:1abc45d1-b001-4734-8806-901211bb2d73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11697","original_object":"UniProtKB:Q8TDU6"}
{"id":"90eef730-76fc-4173-a926-ca1f332cdf5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:cc8a22cc-3a91-42a0-86be-db1705b08adf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:Q9QYN8"}
{"id":"a6dc7273-0258-48cd-884a-c1847c3ccd69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10112","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:7d199665-d8d0-4b6c-8283-31030e19c547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5297","original_object":"UniProtKB:P09917"}
{"id":"a21c502a-9760-4b51-8908-eb47453be60f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167636","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:fc68ee7b-bb31-4040-b936-5df59fe6c9ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7332","original_object":"UniProtKB:Q96GD4"}
{"id":"86324187-9997-43a7-8255-a1da3ae3d81f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2038","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:bfa82c49-36d8-4219-ba06-3775bc48bdf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2038","original_object":"UniProtKB:P30874"}
{"id":"d387afc4-cd33-4bd9-b23d-4927dee955ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2059","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:f2f8952e-c5bf-46ab-b374-c6c784730530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2059","original_object":"UniProtKB:P32745"}
{"id":"4dd06240-7ca5-46c0-b8e7-16417bc31f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9948320","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:b221da70-c840-4bc2-9bfc-65dbb668f8a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:289","original_object":"UniProtKB:P11229"}
{"id":"791f0bbe-6561-49c0-9334-a295d12da652","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71622431","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:dd5e287d-0f05-4479-869a-23135d1049f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11878","original_object":"UniProtKB:O60674"}
{"id":"81748014-1e58-4987-a434-dcfb6451e9e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9985526","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:fcf20789-b23f-484d-8896-1e8d77afad3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:293","original_object":"UniProtKB:P08172"}
{"id":"43f58a97-2b9d-4718-88b9-70d277349850","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68621","predicate":"biolink:affects","object":"NCBIGene:5476","sources":[{"id":"urn:uuid:8cdc40ad-3fe2-4154-b921-4907d8487c16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7876","original_object":"UniProtKB:P10619"}
{"id":"1043aa1e-f33a-46dd-b7eb-d24b5b567082","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:8dec5c14-d300-438a-a346-2849543c0338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P30557"}
{"id":"df3e8068-756a-4c22-ba82-4af44b0ace55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LQ52UF48A","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:48567056-e589-47ae-aa98-57b3892142b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5945","original_object":"UniProtKB:P11802"}
{"id":"00c1a9f3-cf3c-46e0-9017-69d46c6818c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92341","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:9bbc8cba-9211-430f-a21e-11011a9a554b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:15","original_object":"UniProtKB:P08908"}
{"id":"9347220b-116e-4ccf-9048-d8ddc998251c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11176403","predicate":"biolink:affects","object":"NCBIGene:60628","sources":[{"id":"urn:uuid:3e75b7d4-d058-49f2-84b4-4f9b35df38cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2900","original_object":"UniProtKB:O08565"}
{"id":"88fcb0a3-7cf7-4ce3-b4c6-00d607518302","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435402","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:acbc7059-3b55-493e-9b7f-0048e7ceb169","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1950","original_object":"UniProtKB:P43114"}
{"id":"8fc71f3c-b401-46c1-bea0-e1753a858076","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2075","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:6275502f-5773-420f-b6be-a6305cd9eab1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2075","original_object":"UniProtKB:P32745"}
{"id":"189f499f-10f3-4e56-8012-621ec80afabd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17276","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:76b81a59-cfeb-4787-8ff0-1fa020cd32fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4285","original_object":"UniProtKB:P59534"}
{"id":"644d0dd5-d587-43d2-a673-f25de9735f70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:64CW205BDD","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:e2f78b52-ccea-4ff0-ad2f-8a7779363b3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9800","original_object":"UniProtKB:P48736"}
{"id":"a2db19a6-b812-4940-9218-7e24a3be8d00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135899","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:55063227-c700-4b1d-9308-6e118ac82519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2213","original_object":"UniProtKB:P70536"}
{"id":"148d8ae2-e60f-4db6-87e6-4075bff2fa9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40237","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:6a50aa40-0d1f-48f0-9bad-3fe370e7559f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6286","original_object":"UniProtKB:P27487"}
{"id":"d92c3094-aa07-4f58-9364-a5f19de2888e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163410393","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:f0f7ce4f-b7fa-4f35-9f1b-6c23c03a9cd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12057","original_object":"UniProtKB:P08253"}
{"id":"a1935b91-ef0d-4833-a678-a507b0b78fd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:10cb8228-2425-44a7-94fe-8923111ee4a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P14867"}
{"id":"b4c5916c-078c-4980-82df-5f16f1a8f3fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11751175","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:2a494cbc-3d13-4a4a-a831-e9619ce3a693","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6265","original_object":"UniProtKB:O88536"}
{"id":"ef9b6fdd-4a93-4ab0-8aee-cc13813d0144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77961","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:a363dac1-467c-4e8c-b0a1-6436da9af159","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2916","original_object":"UniProtKB:Q9UBY5"}
{"id":"ec7d8754-7cc9-42d9-8e65-14be49888cde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190022","predicate":"biolink:affects","object":"NCBIGene:5337","sources":[{"id":"urn:uuid:87010d82-f28f-4734-bd44-a530b05accde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8781","original_object":"UniProtKB:Q13393"}
{"id":"5c69a501-9021-4f1b-ba5c-93165a2cba16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947006","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:a19f30e4-54d2-436b-8433-37f5e0e1c3db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3212","original_object":"UniProtKB:Q62967"}
{"id":"50444608-14fb-4413-bc37-575f633b891e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:3b2c7168-8d84-400e-9583-10368a3b680b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P30680"}
{"id":"1ea70de8-0e00-473f-b0b3-9997589ab0cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4469","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:6057a6b8-038e-43f3-80d8-fc86a60c1a53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2147","original_object":"UniProtKB:Q923Y8"}
{"id":"355b4bee-de82-465e-84ff-a3fa8f946213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6U9WP10T7","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:9a2bcf02-f22c-4234-8066-61be976c86e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7885","original_object":"UniProtKB:P12931"}
{"id":"899a0d8c-f224-4726-a641-eb4d5aa414f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996530","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:6d2b5bc9-53ba-4c4d-ac41-c1a97c86723f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10606","original_object":"UniProtKB:Q02750"}
{"id":"c5bc88d1-97ea-428a-bc0a-5f8df9694ab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2994072","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:ce024ec1-34ca-4813-9ba3-6942b62351b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1257","original_object":"UniProtKB:Q9Y5N1"}
{"id":"2e30b286-6322-49da-97a6-16cb6896859c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:3b7fb631-ed8c-4340-b8c7-7962d1f30705","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P08173"}
{"id":"da14ec2f-7cee-48c4-b9dc-eafeb80ceccf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D9F5G5D3GN","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:8ce94925-be13-4846-aa7b-93154b2d04db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11411","original_object":"UniProtKB:P28482"}
{"id":"c842dbe8-54f6-4113-9084-ef473aa7193b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:fb61c45a-6b38-4f23-991b-1152096bae62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P25099"}
{"id":"1538c977-eb18-4b72-967e-2897403ad08c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5843","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:9e291032-ed9d-4bed-8bcb-2814064abb7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5843","original_object":"UniProtKB:P33766"}
{"id":"2780bd1b-1dc6-4511-9a9f-178d8b668c26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:2f3d059c-4ba6-4d75-a1a3-94f4d972aa27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P08482"}
{"id":"0d1f573c-9deb-4389-b699-3bafad5117d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755230","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:92981b55-51b1-4a86-9f61-70cecd0db906","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6658","original_object":"UniProtKB:P55085"}
{"id":"435e6943-9641-4732-aa9a-62bc124fccc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890547","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:3450d6e1-8077-4c6f-aa22-0abfd927d246","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:490","original_object":"UniProtKB:P35368"}
{"id":"1f7c2594-847f-4ff9-9fe4-2975798414f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52013","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:bc91331d-64ae-42ff-b6dd-5cd8e4ab2ff1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1213","original_object":"UniProtKB:P35367"}
{"id":"fe388332-9b57-47ba-85fb-ddb49c083cdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:dae5277e-47cf-493e-98ab-b50aa90a5a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P34969"}
{"id":"9bbf983e-095f-4e8d-bcc0-e45182ae8db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87283","predicate":"biolink:affects","object":"NCBIGene:1454","sources":[{"id":"urn:uuid:515ba488-975a-4e52-9ace-106c4b7ff16e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9371","original_object":"UniProtKB:P49674"}
{"id":"d9afc8ed-a96b-4204-b22b-2f4a6016be10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6754","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:de8405aa-28d4-4b91-bd93-ed32de121d49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7221","original_object":"UniProtKB:P41143"}
{"id":"e7f58593-f7b2-45b8-a64a-ff5cbdbe36d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59414","predicate":"biolink:affects","object":"NCBIGene:22861","sources":[{"id":"urn:uuid:586afa30-9cac-4762-b787-74fd262d90db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5024","original_object":"UniProtKB:Q9C000"}
{"id":"da792d30-9b4c-479f-8f86-80e4940660e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92263","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:4128a649-f430-4d5f-a243-9173e9e492df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4179","original_object":"UniProtKB:P31644"}
{"id":"40ea3010-9de4-4f21-81b5-a117632c008e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5543","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:4861a8a7-ed3a-4357-ac47-fa88bfb0f3ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5543","original_object":"UniProtKB:O35433"}
{"id":"73a7ea5c-edf9-41cf-a84a-a6b3e5e56702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:14608","sources":[{"id":"urn:uuid:ed0f5e98-2986-4ca7-9bb2-9457e4c9c11e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P30731"}
{"id":"55d22cdd-e0f0-4848-96d5-399d726a8408","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T4SR539YKF","predicate":"biolink:affects","object":"NCBIGene:7052","sources":[{"id":"urn:uuid:c1a123c4-e084-4a70-8b8e-ace2633628d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12802","original_object":"UniProtKB:P21980"}
{"id":"70f3fee5-54a3-41af-a6b3-58c44bfab92a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118356682","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:b8784fcb-fafa-4ff5-b287-b79256cb21f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11193","original_object":"UniProtKB:Q06187"}
{"id":"6fcc7141-d68d-42b1-9335-45947de9c47c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124990","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:0a7d4506-aeb0-4708-b68e-b3f445a577d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9567","original_object":"UniProtKB:Q96LB1"}
{"id":"5a1bae9f-2f0f-4d55-a92f-5169e2d2357b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54765113","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:e6820d75-3c29-4cc2-9107-6262e4b48bde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9122","original_object":"UniProtKB:O43614"}
{"id":"4860a638-f35f-4b75-bf38-f9bc7a0b3a50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZD6AG3N96D","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:e76b5ca4-4e7e-4668-9950-58c8526f22da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:176","original_object":"UniProtKB:P14842"}
{"id":"5599c4d5-ab2b-4cf6-b003-85a41c1c76e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49847690","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:be58093d-59b8-4c21-8a8b-dbb483386405","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7710","original_object":"UniProtKB:P98170"}
{"id":"5ac10b84-70a4-47ce-904e-8a28df22be2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O6NW23A765","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:72525c5d-7c75-464d-adca-de90562669ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3986","original_object":"UniProtKB:P43681"}
{"id":"3ccd003e-2387-4498-9fc4-48a6d943aecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7K4GKQ4XSE","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:03fe71c7-2748-4ae4-9c14-2669235dbe95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:426","original_object":"UniProtKB:P29274"}
{"id":"705a032b-582d-422f-8600-53a9c8e9fba6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9797919","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:2c94b2ab-be2e-445e-a073-1c97469c51fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6056","original_object":"UniProtKB:P35968"}
{"id":"d57281dd-def3-4add-a0d8-9af240c460cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11401613","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:ec3b3e93-6f08-47b8-ac9b-5c646dc3ca6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4152","original_object":"UniProtKB:P13569"}
{"id":"e9810415-495b-42bb-83fd-af6694046a14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Y1PJ3VG81","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:09797e74-fc6f-4a68-b8ee-fdd89898d7df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9860","original_object":"UniProtKB:Q02127"}
{"id":"70814ac4-e5af-426b-b4dc-77002494b238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1514","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:a01f0b0c-d71e-4d70-ac93-e0b3706a6638","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1514","original_object":"UniProtKB:P50391"}
{"id":"0f035dd6-ef1d-46ed-8f04-fe889076c874","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49840","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:a5dbecd0-801d-4845-81af-53f4eaa44371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7806","original_object":"UniProtKB:P24941"}
{"id":"20477907-448c-406e-bc11-fe07f91f68c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:200HA2LIMK","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:237c05e3-c0dd-4492-ad7e-23d401b18b56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8173","original_object":"UniProtKB:P80192"}
{"id":"0525287f-9d82-45d1-bf6d-d74197054b25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813909","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:409ba5cd-0140-47d7-9355-2780df630d4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10073","original_object":"UniProtKB:O60885"}
{"id":"0d02d90c-03ee-411b-99fd-195353f67ba9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:ca28e344-a8aa-4761-adcb-735f30e051ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:P53671"}
{"id":"eca73b82-97cf-4e8b-b070-82a9997f2d56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:924","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:bc4dbe3b-2b23-4ac3-9ffe-28f72ed6001c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:924","original_object":"UniProtKB:P34998"}
{"id":"a11bcc7e-97e2-422c-8ee9-24c67aeed478","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6Z3QHB00LB","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:379ebb8e-2bd4-465c-a0d3-613eb17bc939","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8383","original_object":"UniProtKB:O00329"}
{"id":"1562354a-a912-4787-9926-0a36d561e9c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45265749","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:8dafeb8c-bfb0-44aa-8d08-f14b3b9bfb13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6724","original_object":"UniProtKB:P17764"}
{"id":"f6ce7252-d25d-4647-ade0-46edbec060fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10428412","predicate":"biolink:affects","object":"NCBIGene:3067","sources":[{"id":"urn:uuid:6d8287da-d041-4cca-aace-37fbf436ca8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5134","original_object":"UniProtKB:P19113"}
{"id":"03c98c82-9a8b-4bb9-baef-a23658ddb5d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2700","sources":[{"id":"urn:uuid:f04dbecd-59dd-4be7-8d3c-7b106a259a13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9Y6H8"}
{"id":"453f4d09-cf1e-44ab-bc34-e5f9fb558a7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78319072","predicate":"biolink:affects","object":"NCBIGene:27163","sources":[{"id":"urn:uuid:34026baf-66d8-4bec-a92c-7d21bc57d464","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9178","original_object":"UniProtKB:Q02083"}
{"id":"25fad240-163c-4a53-8133-afd0787b621b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17898","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:ebaed2ca-ebd5-488e-b575-900328d0fe92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2350","original_object":"UniProtKB:Q00195"}
{"id":"9b2a9572-d2e5-44a5-9e05-1cb1a7b28ef6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44351001","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:5b890bbb-5941-417a-9abb-3947db8cc900","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1507","original_object":"UniProtKB:Q15761"}
{"id":"855394dd-8510-4398-a2b9-1f92922b73af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:97BT14C36A","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:8fd3a874-2f74-4b4e-9b0b-4aa88b198460","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:933","original_object":"UniProtKB:P21918"}
{"id":"d884ffc7-c81a-47af-9ff4-74e81042f2ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A07663A39I","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:476a1bbb-fcfb-4888-9a5c-fdf67ebea2df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2755","original_object":"UniProtKB:Q13133"}
{"id":"0482bbc1-25a0-4786-a03e-2897be18a58c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156539584","predicate":"biolink:affects","object":"NCBIGene:10892","sources":[{"id":"urn:uuid:c61eb1c3-4aaf-48b1-bf29-dfabc4f449e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13295","original_object":"UniProtKB:Q9UDY8"}
{"id":"e8eeae4b-a8bd-471c-9a9e-3f0beca58b32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3935","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:2c0a171e-d97c-435e-a0d7-9deaeb3a0077","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3935","original_object":"UniProtKB:O88536"}
{"id":"e579184c-61c7-4645-a06e-bc3a9fed2bb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134677","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:b5399e79-d43a-4c05-afc9-4b03da6ed4cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9151","original_object":"UniProtKB:Q07343"}
{"id":"02e8eda1-847d-4140-a407-6d075f6b9a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:33897a49-18ee-4e13-9c46-ddd7bc01c791","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P31424"}
{"id":"1f77007e-f476-41b6-b42a-184e46ac3594","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:b0710db8-c34b-4c84-85d4-67b4fe016953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P35368"}
{"id":"e99aa3a9-e044-4072-8f9e-6f8bba69020e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189648","predicate":"biolink:affects","object":"NCBIGene:27346","sources":[{"id":"urn:uuid:26a1a73c-b3e5-44ea-b85b-fc6da36d1b16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6681","original_object":"UniProtKB:Q5BJF2"}
{"id":"ecde702b-2c38-46ec-bc29-61e73e2aba0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11354367","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2c9f2b0f-ebbd-43b6-9bc7-126d25524416","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3255","original_object":"UniProtKB:P08172"}
{"id":"f1aafbf8-1b87-49f3-9f8f-3336d3b8181f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL285043","predicate":"biolink:affects","object":"NCBIGene:60590","sources":[{"id":"urn:uuid:baa3bc35-fd73-41aa-8520-6ecca85cfcc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1408","original_object":"UniProtKB:P70579"}
{"id":"1ddc9fec-53dc-42f1-bc7b-b7798f243f05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:fa398f28-dfd7-49e6-a0c3-265d3e33fb81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2421","original_object":"UniProtKB:P78348"}
{"id":"8a18d094-1c6a-4160-bdfd-b21c301de632","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10310632","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:f0f1d1f8-239b-4ea2-b102-cae450c95d0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9021","original_object":"UniProtKB:Q99572"}
{"id":"43b2a5b9-5763-405b-b973-d819229d4a96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8069","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:1a5b5041-a338-49e9-8c60-9ca225681ad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2804","original_object":"UniProtKB:O75469"}
{"id":"dd0c8200-6df9-4aac-a260-46cc7066d78b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144672","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:ef47c8ba-d310-411b-b244-5cf86dc753bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11060","original_object":"UniProtKB:P23458"}
{"id":"d525e32a-3e53-4e9d-84f9-b515a0cb26fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8988","predicate":"biolink:affects","object":"NCBIGene:12846","sources":[{"id":"urn:uuid:e034a741-ecab-45ee-b6da-1400a1cea587","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8988","original_object":"UniProtKB:O88587"}
{"id":"f2ae9e04-9f18-4227-a64d-cd34102daced","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8978","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:0fd2901a-c9da-44f5-852d-4296651979eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:191","original_object":"UniProtKB:P28335"}
{"id":"168f47c6-4566-43f5-8cab-5f9a50fa8f43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114785","predicate":"biolink:affects","object":"NCBIGene:11309","sources":[{"id":"urn:uuid:13eeaeaa-2d67-498d-8112-0e78dad4c1e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4920","original_object":"UniProtKB:O94956"}
{"id":"04ed3613-eacb-49da-ad71-2f782a5dfb1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2707","sources":[{"id":"urn:uuid:e76bc747-85a1-470f-889f-b791b3714ab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:O75712"}
{"id":"7ff0230e-90f6-424b-bfb9-55a72105483b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118022791","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:067a980b-6bf2-41eb-998e-d22d18f6bcc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10065","original_object":"UniProtKB:P48067"}
{"id":"2c21c6bc-b4b8-4d54-8c82-9fb1b81482ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103931","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:3d53ab46-93df-4ae4-a9c7-c88ca2d3627f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:487","original_object":"UniProtKB:P25100"}
{"id":"7209e429-234d-4dd5-b75b-000df9dccec0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:654","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:077cc57c-eb9b-4d62-9fe9-b81ba18e25b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:654","original_object":"UniProtKB:Q61125"}
{"id":"acdce5d5-509d-47f9-b9dd-f5abd006bfd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452040","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:2fcc5927-0608-4c4c-9476-17ea1f3bd588","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9190","original_object":"UniProtKB:P41145"}
{"id":"e43aaf16-67b7-42ff-ad5f-f97637026f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70773","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:a146844f-c5f4-4dca-8c9a-64c59eb854ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2461","original_object":"UniProtKB:Q8NER1"}
{"id":"98f32e75-1597-4f8b-ac53-eb5ee0595202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:e608b2ec-49f4-4dc3-9e7b-6acee7978830","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30872"}
{"id":"4b1ea4e5-a056-45d4-a716-ab483340eafe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:6b673d6d-ee0c-4af7-9c8d-77bb621f8fd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P34903"}
{"id":"500b4452-fd62-4af2-9cda-199e20ffc5e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13878025","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:8ebb1061-b592-4456-8636-201d47e33021","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:184","original_object":"UniProtKB:P30994"}
{"id":"d1c90c12-ecad-471c-898a-85eddd2ce721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71470549","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:09de9eb0-23a6-4693-847e-7ca5e65701b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10145","original_object":"UniProtKB:P51449"}
{"id":"3e83df23-a231-4f45-b07e-122c37cdbe50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311208","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:7ae74c21-e560-4414-8cbf-1cf3824a71f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1890","original_object":"UniProtKB:P34995"}
{"id":"0769c854-2489-4bb5-8d8f-8ca5132695c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44915","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:bf5eb689-7b48-4f15-b599-baef8e2aebce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:5464","original_object":"UniProtKB:O88704"}
{"id":"9056004b-a6d2-48f4-9630-049cdfb3ff2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63450","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:b41e1a27-7a6f-4d20-a47f-36cc414bc8f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5656","original_object":"UniProtKB:P09619"}
{"id":"af026eb2-afa0-4d30-a159-dfd5a24f9ab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155142832","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:0db540ce-858a-47e1-9ae6-c3e97f138ef8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11588","original_object":"UniProtKB:Q9UM73"}
{"id":"ff0b005e-c35c-4bb1-a0af-8d2bcd6120f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54579974","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:a363f81a-6766-4f94-96a0-f98cd9df4e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7756","original_object":"UniProtKB:Q99705"}
{"id":"06624d60-bd4d-4205-9e8a-30918b6bbc29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEDO9QXYZK","predicate":"biolink:affects","object":"NCBIGene:8140","sources":[{"id":"urn:uuid:fbe1bc5a-05c4-4626-b92e-086770ccfff4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9347","original_object":"UniProtKB:Q01650"}
{"id":"604d17df-2865-4838-95cb-ccb592be79fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:13fb82ad-fcc6-4047-b1fc-fd0bd9824da1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:P06239"}
{"id":"44d53dc3-2f06-4b65-a5f6-2860e011ca70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:112f6eac-7229-4f62-bd63-11f32795d087","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:Q13547"}
{"id":"3e629476-1ca4-4651-8166-ae394d4f349a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48967","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:860912e7-49b0-4f36-9aa7-be0f716922c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12443","original_object":"UniProtKB:Q9NYV8"}
{"id":"1c1b21bf-d84d-4007-ac35-e6928560562b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993654","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:bdd20c33-3752-427e-b75b-c1ff3c59936f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12558","original_object":"UniProtKB:Q9HBA0"}
{"id":"7f57315e-8bd8-41c2-b302-8aa735edf651","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93757","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:66036c26-bb6c-4781-af64-29e87297fd84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5912","original_object":"UniProtKB:P08069"}
{"id":"1ba17b8c-8fd6-4d47-b3b9-371ea8bbb02b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4345957","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:daff71c8-7f9b-4f6d-be12-2dc714dee29f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:613","original_object":"UniProtKB:P28336"}
{"id":"927c1baa-38ff-4441-97e1-548346639425","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:8e11e116-9d4f-4400-8b62-d169603f2cf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P08581"}
{"id":"36a72584-1d7e-4d64-a535-1f886a048c7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E2Y97PQY3A","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:c85a9cc4-cf1d-45f9-a21b-091645223fa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11293","original_object":"UniProtKB:Q9Y5N1"}
{"id":"7972b92e-ec45-4c20-98f1-81412dee9fbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177440","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:03ef9885-74b9-4f8e-9b87-868256d2b890","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1640","original_object":"UniProtKB:P35372"}
{"id":"912681dc-8f7a-4e14-b501-74c1bdf064dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:05b7ac6f-0bcc-4079-a827-18dd8ab6569c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:P29275"}
{"id":"fbe35ac4-98c5-4e55-a43c-d444f12b8d25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2353","predicate":"biolink:affects","object":"NCBIGene:25411","sources":[{"id":"urn:uuid:a3baef80-e6a0-401d-b8f3-de0d2998d52b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2353","original_object":"UniProtKB:Q00195"}
{"id":"be475368-d2f1-4ec7-8ec5-3b1221bcb9dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138522180","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:104dd4ac-5a44-4b04-9c16-d57982f4e8d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13217","original_object":"UniProtKB:P49760"}
{"id":"7b12f6d5-40e5-464d-b6e6-9bf45d32e20f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:5a9175e8-437d-4d2a-a0dc-b3817d49f386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P21918"}
{"id":"c6595008-00c0-4e0d-a759-60c3d50b4fa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:a385da01-058e-42dd-b796-de2e1531a510","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:P23415"}
{"id":"ac1e3bc7-64d8-492d-83e5-49b2078865ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63629","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:ce6479d4-c0cf-4e90-a47f-6e35babd7e05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7308","original_object":"UniProtKB:P18089"}
{"id":"8c74efe0-9c30-46bf-8515-cb6112333e1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2060","predicate":"biolink:affects","object":"NCBIGene:20605","sources":[{"id":"urn:uuid:8528e42c-c75f-4cc1-91cc-797f871c1426","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2060","original_object":"UniProtKB:P30873"}
{"id":"f5907839-6beb-4ec9-8676-ebda90f7bf75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71696703","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:97383ba3-f0d9-429a-a16c-6244beb0a3c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12070","original_object":"UniProtKB:Q96GD4"}
{"id":"74383809-4a79-4f97-8989-3cf18100be29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4466","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:1e932bbd-4f7e-4e56-a291-340da232ca7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:521","original_object":"UniProtKB:P18089"}
{"id":"3697597d-6c5c-435f-b7a4-8ab97e947502","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:635","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:a6c9e614-42b4-456c-9dcb-4214755219ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:635","original_object":"UniProtKB:P52500"}
{"id":"e4362518-3235-436b-8cc7-d08fb8549f77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31669","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:8d441e02-0b71-4b2a-88ae-4bb35327afa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2823","original_object":"UniProtKB:P03372"}
{"id":"c99c06b1-daa8-45fe-bf36-3bfe5e997087","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11289644","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:b5375468-91cd-4c0f-ba45-a9b9c68fb817","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4298","original_object":"UniProtKB:P56373"}
{"id":"1593ab8a-ff05-4b34-8f9c-c98de087ac59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3647","predicate":"biolink:affects","object":"NCBIGene:2829","sources":[{"id":"urn:uuid:50f4c7e3-048a-4994-8021-0d9e5fa3cf01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3647","original_object":"UniProtKB:P46094"}
{"id":"73ebb2ca-6c88-451a-8885-99110d99bed4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918583","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:5ec9bded-c811-4219-a828-2d2ebde1787b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4257","original_object":"UniProtKB:P34903"}
{"id":"c72ba45d-1735-437a-83a9-67a911ff4d7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49835928","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:c300065f-54f6-4bec-839a-af52471a1709","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10311","original_object":"UniProtKB:O95977"}
{"id":"2a9b4fc0-f1db-4a1f-8f5a-bec991d7974c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10296561","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:c1523755-8064-438b-ad21-9b64babe275a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7361","original_object":"UniProtKB:P41146"}
{"id":"f3441efb-bdef-4da3-b15e-f9d7dcf3c329","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4RA0KN46E0","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:bb24e144-b0a1-4093-b50d-c36e5c45b656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9246","original_object":"UniProtKB:P52333"}
{"id":"c896b838-bd97-4544-8144-df48ca3d4edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13352","predicate":"biolink:affects","object":"NCBIGene:4851","sources":[{"id":"urn:uuid:20825184-cc79-4e79-bcfe-60f81b531fa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13352","original_object":"UniProtKB:P46531"}
{"id":"01850641-5642-4b9c-90b7-9c3c8496cab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194339","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:b5498b7d-e943-4e74-ac22-cb28a327a7ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7718","original_object":"UniProtKB:O95180"}
{"id":"c685e452-c70a-4ac8-93d0-c5bc19a773aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D77H8321PB","predicate":"biolink:affects","object":"NCBIGene:9970","sources":[{"id":"urn:uuid:ef816191-d222-4e66-a787-793db460b660","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2758","original_object":"UniProtKB:Q14994"}
{"id":"579c5b9a-c50e-47bf-aa2b-d67dcb910c09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5707","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:7fdb99da-5439-4fd7-b0bd-5d0eeb0fe465","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:323","original_object":"UniProtKB:P08482"}
{"id":"f5f63b3a-b361-4d3c-94a6-abafa37540a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101096","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:4891af54-6577-479b-8b0b-7dbc43df0ce0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6814","original_object":"UniProtKB:P43166"}
{"id":"fd632aa7-b9e0-4789-9dab-77a03b04c5b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135156","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:96db457a-0683-4510-881e-346f65689b59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2301","original_object":"UniProtKB:P46098"}
{"id":"9b9aa031-fccb-45ec-96f9-5bfc0ec3898e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452041","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:e3a9f063-4b2a-4763-85be-ff4ecaa4a90c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9189","original_object":"UniProtKB:P35372"}
{"id":"97e2cdec-b31b-4f2d-a789-514b45f2813a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:f8fa1268-28d8-4c2c-b616-42b117f56a62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P21731"}
{"id":"dcd1acc5-b6cb-49c1-9e92-cf39bf6e4098","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2612","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:85bad0ca-16cc-4f52-95f0-49edb0e61367","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2612","original_object":"UniProtKB:Q12809"}
{"id":"46e31395-b293-4ad1-9e32-26f660074686","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93015","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:080d929a-908c-4cd1-9ddb-8aef316fe510","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3274","original_object":"UniProtKB:P20309"}
{"id":"45d6e1c6-0e7a-40a1-85d3-bc393527b9b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166625060","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:78585929-e004-46bc-a82d-4db8710d15d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12505","original_object":"UniProtKB:Q8TDU9"}
{"id":"1cde7097-b31c-49e3-8ecd-fdc32acfbb93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5635","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:01a68a53-7fc6-4bfa-949b-47f54b5f65d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5635","original_object":"UniProtKB:P30874"}
{"id":"caedb9bc-c522-48fd-a99e-aca243ab4ce4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993644","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:dc66dea3-5a6d-4799-b596-f80f603092bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12490","original_object":"UniProtKB:P55085"}
{"id":"79e16fc8-9e50-49ea-bf50-53eca2aac789","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:789353","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:5abd8de5-228b-436b-890c-b91ea4dc6978","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8774","original_object":"UniProtKB:Q6DWJ6"}
{"id":"dd8fde70-dedb-4edb-bff9-a5640f825dbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:9d82f6f0-79cc-41f3-b808-056840d9a5ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P18089"}
{"id":"4c49bf52-7b15-4de8-8aa6-fd5dd9baf88a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166642424","predicate":"biolink:affects","object":"NCBIGene:8491","sources":[{"id":"urn:uuid:9230783d-4bd5-4538-a872-3a3450f73b4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12336","original_object":"UniProtKB:Q8IVH8"}
{"id":"637507ae-311e-40cf-bf4f-49647f00037e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59174579","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:0dc89ad1-88da-42ce-81dd-72f98eff47e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9266","original_object":"UniProtKB:Q06187"}
{"id":"4b7ca470-c215-48d7-a7cb-489f8d7a280d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91083","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:a81efec5-200f-4695-a33a-c22ea7485166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5056","original_object":"UniProtKB:P10721"}
{"id":"811c39c7-19c9-4bd4-b4cb-db6637f50fb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:05PB82Z52L","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:dc3b2ea3-d24d-4961-a5b9-5adf885b5b07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:95","original_object":"UniProtKB:P08908"}
{"id":"afa728a8-7d34-4eba-af47-bf538d7ac82b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10306","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:2aef1641-8017-41ef-9d09-2c128a75c531","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10306","original_object":"UniProtKB:P78348"}
{"id":"f4a8483b-7d83-4fcf-b655-372fd3457618","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168665407","predicate":"biolink:affects","object":"NCBIGene:27347","sources":[{"id":"urn:uuid:2e483d5e-4bbe-471e-88ac-92d3f1bd18f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13089","original_object":"UniProtKB:Q9UEW8"}
{"id":"7ddefcbb-a873-4c79-8b14-fe67b81dffd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48549","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:ae24eead-b8f3-4630-bc45-b0e230c280db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7404","original_object":"UniProtKB:P15121"}
{"id":"b0a85108-eb3c-4ae0-bc8e-9e12bf41c9eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40618","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:d2d9f870-d997-4c30-a98a-fb58c74f796f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5135","original_object":"UniProtKB:P35228"}
{"id":"c7b910ab-9807-4bb0-8a48-66a75c90da3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12540","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:e8a03374-6a03-46a2-86f7-64151c95ff1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12540","original_object":"UniProtKB:Q9NZQ8"}
{"id":"903574d5-8347-4694-8bef-35eb99f05dd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL499968","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:0356778c-58d4-42e4-8291-c23ba0534549","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2317","original_object":"UniProtKB:Q92952"}
{"id":"40aa047e-21a1-4427-90b9-808d556a1be3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135484064","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:58044c03-c587-408c-a338-4f79e07f88b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:390","original_object":"UniProtKB:P0DMS8"}
{"id":"30b9a058-6234-488e-9208-bebb1cda52b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9927MT646M","predicate":"biolink:affects","object":"NCBIGene:3559","sources":[{"id":"urn:uuid:ee51b4d5-2ef7-4af1-abcb-0b6b2ceb01f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6879","original_object":"UniProtKB:P01589"}
{"id":"6361b6dd-615b-4b31-afb1-e404b2c0b7ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38895","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:91cd4d68-e1f3-49a3-b91b-d86e40d2c009","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2368","original_object":"UniProtKB:P23415"}
{"id":"e6c72085-8531-4e07-bff7-d5f6cdea1fe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DE2O63YV8R","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:d949bd04-6bd7-487f-92f3-9d215af4ced8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8678","original_object":"UniProtKB:P08235"}
{"id":"686284db-ccc7-4fcb-b758-5f32c4bb30ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45483813","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:54fa48d5-f0f0-444f-9f83-121549670321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12065","original_object":"UniProtKB:P07550"}
{"id":"893b1c3b-c8a6-46e9-a7dc-afff7e766bf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121430051","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:5398a96b-daec-4e00-a17d-62447d0787b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10675","original_object":"UniProtKB:P41143"}
{"id":"f19995ce-ba55-467d-a67f-e4f5a6a055e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:dbf75e8b-4440-4f2f-ad55-b40fb2db7a4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P28566"}
{"id":"843becad-ee3b-442f-bf1b-040a4ab01837","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146675152","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:71e824c4-eeca-4ce5-8269-17b272813d0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11403","original_object":"UniProtKB:O43614"}
{"id":"d3668502-bb06-4a5c-afdd-8ffb5eaf7e94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817408","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:c5492356-e480-4839-9388-44d64f334774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1460","original_object":"UniProtKB:O43193"}
{"id":"0d9b211b-fe07-49fc-939f-c31a6a5e3837","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13715","predicate":"biolink:affects","object":"NCBIGene:7398","sources":[{"id":"urn:uuid:6e1b1597-c00e-4678-8932-751ba2566c64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13715","original_object":"UniProtKB:O94782"}
{"id":"d18f8050-6002-459d-b47e-913109e16274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154701097","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:56ad2e22-9a67-40fe-892d-00bdb7eb9c06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12985","original_object":"UniProtKB:P00533"}
{"id":"9705e392-8410-424a-b93a-eff06fca40d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101882820","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:ea87f287-dcae-48b9-b71a-72b9b439e036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13945","original_object":"UniProtKB:Q9Y5X5"}
{"id":"552c3583-4ade-490b-a3ae-d6c0fd4d1e68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28368","predicate":"biolink:affects","object":"UniProtKB:P0AES6","sources":[{"id":"urn:uuid:e582629a-0171-45d8-8f4c-dce161a63827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12021","original_object":"UniProtKB:P0AES6"}
{"id":"97503b5a-a93d-4cf6-a27f-65dd96b9e936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71509622","predicate":"biolink:affects","object":"NCBIGene:6547","sources":[{"id":"urn:uuid:42c8c8fc-d465-41f6-be8a-1ac54608f154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13934","original_object":"UniProtKB:P57103"}
{"id":"e00827a3-d13d-43a9-85cc-f33b4967b29e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57339564","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:eb3175ca-2fa0-437b-bd67-8b11129af1a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1516","original_object":"UniProtKB:P21555"}
{"id":"f2a66810-f753-4f73-badf-eab757e0dc40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4023","predicate":"biolink:affects","object":"NCBIGene:24408","sources":[{"id":"urn:uuid:c19c4a5e-9d2f-4e43-ac8e-235a5c3b7549","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4088","original_object":"UniProtKB:P35439"}
{"id":"80863d28-bd87-4904-b8ab-c8fd6bd23c02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15984632","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:f543e153-1e63-4e51-9bb8-649c7dd3a7e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1943","original_object":"UniProtKB:P30557"}
{"id":"e65e897d-a4a2-4ab0-ae20-905a3a718fb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9765J8QB7Q","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:770373b8-a720-4780-9256-365c4b19af09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:387","original_object":"UniProtKB:P30542"}
{"id":"2d70e7c7-1c56-4779-8ad9-970b47d62bf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11369932","predicate":"biolink:affects","object":"NCBIGene:6505","sources":[{"id":"urn:uuid:56a19e9a-0174-4d4b-95a0-2704324e317f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4626","original_object":"UniProtKB:P43005"}
{"id":"3d145c5c-3bac-4f07-bb8d-ab9e31db81e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3086883","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:b4b28f08-ba55-4e9b-9261-3ae3083171b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7509","original_object":"UniProtKB:O60885"}
{"id":"c995ba84-c414-4807-926e-f0a79c4e0872","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232516","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:b81609b3-d7fc-492a-9b2e-8b1520a92cf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6465","original_object":"UniProtKB:Q9HBA0"}
{"id":"66898952-5762-4934-8b02-eab01d1e5d0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134405105","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:8d3c5d13-491d-4850-b35f-a71018365272","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12621","original_object":"UniProtKB:P23458"}
{"id":"e026bfaf-0ca7-40a4-93c1-014c78b35da6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66553168","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:db85482c-bfbe-4eab-8d29-c4a1a1c6a128","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6483","original_object":"UniProtKB:O14842"}
{"id":"80da9df3-f8e2-44c1-9eca-4bb7d868f290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11460","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:f8f441e4-3113-4759-af88-bbf68a3fe27e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11460","original_object":"UniProtKB:Q8TDU9"}
{"id":"a8afe47e-c425-4826-82c6-1e1e4aa75027","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10468943","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:6ab97df9-ead6-46d1-812a-5b2feaa2015a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6990","original_object":"UniProtKB:Q9EQ31"}
{"id":"78dee824-5b9f-486d-bffa-3494e6d0ddd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312148","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:d6524117-92b6-4924-ace2-d46af416ecde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:281","original_object":"UniProtKB:P34969"}
{"id":"1f3acac6-e1ee-40ce-b9e7-97350c5adf6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12966","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:d79ac613-c26e-4ef9-aa07-54248b83b47c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12966","original_object":"UniProtKB:Q15116"}
{"id":"9f7c62d3-0f5c-49df-b8b7-94b500f58a85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31905","predicate":"biolink:affects","object":"NCBIGene:3767","sources":[{"id":"urn:uuid:8a924374-d28e-4755-adb3-7d66fc4c1785","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2411","original_object":"UniProtKB:Q14654"}
{"id":"bbbf2a13-5593-4e93-84eb-51719424157f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755088","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:8d6120b9-ba07-46bb-bba8-90a87b9d33d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4276","original_object":"UniProtKB:Q13224"}
{"id":"ffb62c5b-a624-4c0f-be8f-934bf5dd0f4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:94652","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:5a9da708-8ada-47df-abd9-b5939ad6c1e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10337","original_object":"UniProtKB:P57789"}
{"id":"fc57bbb6-fba2-42ef-b1c7-824bb393f466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135530","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:8891e9a8-52a0-4087-8dd0-9875e1e295dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7483","original_object":"UniProtKB:P08482"}
{"id":"74eb68ec-467d-4e27-a7f1-3c2096626333","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688690","predicate":"biolink:affects","object":"NCBIGene:10420","sources":[{"id":"urn:uuid:acd0f7d2-4244-4852-b6f8-eecc23595c4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8118","original_object":"UniProtKB:Q96S53"}
{"id":"a3cb468e-e62f-44f6-9b52-4e85f7104900","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:88960980-6ede-4f22-8a9a-86d8788f7fb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P30543"}
{"id":"dda8f260-63a5-4f02-84d5-39b037caca1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134724","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:9897cf26-ca12-4d28-aaf0-db1c1e0272ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9394","original_object":"UniProtKB:P13866"}
{"id":"ba23e56e-bff4-43d3-bd5c-f51c9ba14de6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q77EAZ9TG9","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:cfbec60b-f215-4bd9-a010-0ec232f155e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8434","original_object":"UniProtKB:P34969"}
{"id":"18581668-7165-43b5-baa7-f99309edb7c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2622","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:840e59da-9090-4ca3-9b49-3b0ceb0da084","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12459","original_object":"UniProtKB:P59540"}
{"id":"31a485b4-2f44-421f-b9b5-16ddffc39f17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2255","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:c2a11b6a-3add-4f28-97d7-c0b61a85563c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2255","original_object":"UniProtKB:P30559"}
{"id":"bcbc4d19-8974-4acf-85a6-6094e32c300d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:576087I4XG","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:5d308d75-dac1-4f78-a1c2-decbf4babda0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:358","original_object":"UniProtKB:P08172"}
{"id":"33ce4d8b-6189-416b-afe2-89bf0bafbd83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5263","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:3a005dee-1c42-4dc7-bfed-09d2ed091478","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:402","original_object":"UniProtKB:P25099"}
{"id":"c5196d19-14e0-43a1-934c-55bdd8ac0b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118165440","predicate":"biolink:affects","object":"NCBIGene:27159","sources":[{"id":"urn:uuid:32e1c28e-c8fe-482f-b689-e6122dd037ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9780","original_object":"UniProtKB:Q9BZP6"}
{"id":"7d7191fc-754c-4346-b677-efbb05687992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8977","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:eadcecdc-d434-4393-8a76-615dcacc5803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:189","original_object":"UniProtKB:P41595"}
{"id":"f4c63a3a-166e-42f1-b92a-0415fc183a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:a5231926-a581-416a-98c6-38d52aaa7ad4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:P0DMS8"}
{"id":"cfeb96d1-2901-427c-817e-2be3e47e820c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167729","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:54e64ace-cc6c-4cb4-bdc7-7bbe7f15f851","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2506","original_object":"UniProtKB:P20272"}
{"id":"52fcd13d-08b8-43b4-8f6c-e92d8d660f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:2157a81b-df8e-4fdc-ba01-f1a1b342c383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:O15379"}
{"id":"d8821aa6-ca32-4e80-b712-fc458ff08a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TR7I0800L2","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:e8ab991a-90ce-408b-906f-452ba5e04091","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4328","original_object":"UniProtKB:P24046"}
{"id":"4bb6e665-037e-4985-8a66-4e1c716775ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5004","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:f2f14c9e-a06d-41ef-8fc7-fe1f015a734b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4820","original_object":"UniProtKB:P23219"}
{"id":"c58e003e-a8da-45af-9eb5-084006c3c2a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8323","predicate":"biolink:affects","object":"NCBIGene:3821","sources":[{"id":"urn:uuid:1f0037ec-4cb7-4f5e-a2de-632202b04ecd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8323","original_object":"UniProtKB:P26715"}
{"id":"f0296007-a747-4826-9fed-a99499194813","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X7REK61AIS","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:ecaecdb3-5907-41bd-bbf4-662a80ebc9b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8417","original_object":"UniProtKB:O15552"}
{"id":"4dd90552-935e-49ee-aa2b-685f13835b45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3165","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:c43dc598-07c6-47b0-b962-069976b7598e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:649","original_object":"UniProtKB:P97583"}
{"id":"9931ca5a-ea33-4270-8f56-11d94f19c20a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:e7acfbbc-9391-4b09-ba26-211e2f162bac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:P23458"}
{"id":"b160856d-ac19-40c4-b46f-babc90a24e8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5P363AFVC","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:6718440d-a9aa-4131-b7c5-da20b4244a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2638","original_object":"UniProtKB:P10827"}
{"id":"a7330faf-2e0e-49e1-9757-f2da3267e5b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:a088ff20-73f8-4f50-98e2-16e9c134453e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4090","original_object":"UniProtKB:P34903"}
{"id":"2e576ed2-3d36-4000-8df3-eb23699c9db2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5811","predicate":"biolink:affects","object":"NCBIGene:319239","sources":[{"id":"urn:uuid:d6737d86-2042-4a40-956e-5481e91d460a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5811","original_object":"UniProtKB:Q8BZP8"}
{"id":"79f2de6b-88cd-473b-948a-57e5bca1417c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996538","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:fd338bbe-423f-440e-9e14-cccfeb1371f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10672","original_object":"UniProtKB:P09874"}
{"id":"222de69a-96fa-4830-9aa9-d2654d4e96c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13791","predicate":"biolink:affects","object":"NCBIGene:4070","sources":[{"id":"urn:uuid:2a19ff17-99ac-4317-9f45-559ca5f42e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13791","original_object":"UniProtKB:P09758"}
{"id":"fd70246e-dc9b-4506-864d-7113319b8ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2637PDX9SI","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:465ac124-0211-4c71-acd9-d0293c98cb62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:873","original_object":"UniProtKB:P56481"}
{"id":"4b3e9b8e-1ccf-42e7-bc4f-147a8475a4a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233362","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:da0aaeac-36c2-4a56-9d9d-63f899a2d273","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7382","original_object":"UniProtKB:Q00534"}
{"id":"d4f14939-facc-4107-a685-737fd9692368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6706","predicate":"biolink:affects","object":"NCBIGene:8973","sources":[{"id":"urn:uuid:d15ab0a8-d384-4849-ba07-eda2563a964f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3990","original_object":"UniProtKB:Q15825"}
{"id":"f84c213a-ceb6-43f4-9f7a-31ef15e32dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:771","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:e45ef781-f200-44ea-b285-444771bc2383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:771","original_object":"UniProtKB:P51677"}
{"id":"2c3a02c6-f6c1-40c5-9ff4-e063f52a3a89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164726578","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:e9ff1745-b03c-48af-9c42-9c30c3ca91ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13368","original_object":"UniProtKB:P01116"}
{"id":"fbd53945-96e8-438b-9568-549902b8c88c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:08a0bf2f-5e87-4a78-a1bf-5d021008a06f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:O88626"}
{"id":"322ebfec-0db0-4684-acc8-b562d6790b64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63580","predicate":"biolink:affects","object":"NCBIGene:3615","sources":[{"id":"urn:uuid:246d6992-936b-4ddb-a27e-b505c8da90f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6842","original_object":"UniProtKB:P12268"}
{"id":"0b050192-79fa-48bd-9346-d1fc1f1a3151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:6788","sources":[{"id":"urn:uuid:9a511dcf-d4a1-4c52-a7c1-f04dd3ee41ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q13188"}
{"id":"102f79fc-7803-47e7-8355-aef6d9ce701f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:125111","sources":[{"id":"urn:uuid:8e0b67e3-7b78-40bc-bb2d-39c803b3d480","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q8N144"}
{"id":"9f5b1cf8-c07b-4fb0-9a39-5feb42df28e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441294","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:55a2e818-72af-4e6d-959e-7cdc1b97c3f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1862","original_object":"UniProtKB:Q62035"}
{"id":"27f798e1-2611-41c1-ac4e-5a4a1535e5ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56707820","predicate":"biolink:affects","object":"NCBIGene:8111","sources":[{"id":"urn:uuid:a5d2840d-1d94-44b5-ae7c-276ab3bd17cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9155","original_object":"UniProtKB:Q15743"}
{"id":"63ee0556-515d-4632-ba27-55e31c456a71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:17eeff71-201c-4371-bec6-04d6626dcd99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30872"}
{"id":"3f2865ee-9502-43f2-b7ee-146e0c9db767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2525","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:0ef7723c-a739-401a-979f-cca920dcb3ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2525","original_object":"UniProtKB:Q9UL62"}
{"id":"5e695209-c45d-46c3-a008-d9dd776db3b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5288811","predicate":"biolink:affects","object":"NCBIGene:25302","sources":[{"id":"urn:uuid:aecedab3-fdf9-40d3-a405-5efa4ea10e6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3980","original_object":"UniProtKB:Q05941"}
{"id":"19095af7-a520-47d5-b630-3133822867ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10227892","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:e46431bc-17da-46a2-afc7-fa71ed2c3c29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8537","original_object":"UniProtKB:Q13258"}
{"id":"450f5906-0a97-4f67-9e30-1d1028d109c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:a778dbc3-f0ac-49ac-a0a8-4d45fa3b30b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:O08858"}
{"id":"41763ce3-8489-40ad-94a6-cc631f5fee7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19DG7G1U5Q","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:7b8490a9-97cc-47e3-8d89-b02e9682dd1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8917","original_object":"UniProtKB:P48736"}
{"id":"0e6dc47f-3c2b-4598-af46-67407062abc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9851134","predicate":"biolink:affects","object":"NCBIGene:834","sources":[{"id":"urn:uuid:60f52a2b-5fd9-4a9f-b524-bda6cee268b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8654","original_object":"UniProtKB:P29466"}
{"id":"9ec747e3-d277-4be1-8213-621507b188b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4KW1M48SHS","predicate":"biolink:affects","object":"NCBIGene:330","sources":[{"id":"urn:uuid:9969337b-0093-47c2-a894-8f2abff3a667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7733","original_object":"UniProtKB:Q13489"}
{"id":"43a53792-9180-4618-b4e1-62d8cb4a0de7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y778RDH3Y6","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:08454bab-fbc5-403f-8adc-b33b053b2852","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1304","original_object":"UniProtKB:Q969V1"}
{"id":"798f2d21-a634-4e6f-a797-18a3820dc65f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13953710","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:81e38224-bedd-4769-846b-94de0fad1191","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7514","original_object":"UniProtKB:P25440"}
{"id":"9c057062-99bd-4e0d-ae4d-3faf97501af2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91403","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:ae3fa173-28bf-4ce6-b11b-3e74d792de05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5986","original_object":"UniProtKB:O14920"}
{"id":"dccb4074-1495-4191-b290-a61a774e17ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2258","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:b30699e1-0503-4a19-b8c3-121940b5c52c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2258","original_object":"UniProtKB:P32241"}
{"id":"e281d5f7-5911-472d-9a17-28bcbe460fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3B2GI648A","predicate":"biolink:affects","object":"NCBIGene:941","sources":[{"id":"urn:uuid:32bd3e29-f61b-4e2e-b889-7065c530ed18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6892","original_object":"UniProtKB:P33681"}
{"id":"3e28caf7-5ce6-47e9-80c8-484d1966577a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91433","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:68fd2807-ac4a-41fa-884d-3c0fc8b436a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9383","original_object":"UniProtKB:P35968"}
{"id":"e96f8df7-8fcb-4dd7-9a74-1c418db395f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230775","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:fe06abf4-977d-443c-8c46-252c420de197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11377","original_object":"UniProtKB:Q8NET8"}
{"id":"4fe7103f-1e84-4944-a066-da69f305cfb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71957","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:c0f5e626-c927-4c20-af00-63c332dc83c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7963","original_object":"UniProtKB:P48736"}
{"id":"7c56e8f4-aca2-4d44-a59d-ba9ba088f25f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12843","predicate":"biolink:affects","object":"NCBIGene:389400","sources":[{"id":"urn:uuid:4856fd57-f737-46ee-be4e-47b5f705f8dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12843","original_object":"UniProtKB:Q6UXV0"}
{"id":"f6bae406-07e6-48b4-b9bc-a7a851c6998c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91407","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:b74fa925-7a82-4bb5-846f-a0d61ef4da64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7791","original_object":"UniProtKB:O60674"}
{"id":"58168657-0827-48ab-b35b-093efe7204c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85966","predicate":"biolink:affects","object":"NCBIGene:348980","sources":[{"id":"urn:uuid:30942d39-23ae-49a0-b2ea-2f5f6abe2bad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2357","original_object":"UniProtKB:O60741"}
{"id":"0feecfc9-e1d6-4efe-b1da-efff4ec8f477","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:612c08c8-3a11-439e-8901-d0d135f74f76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:Q60614"}
{"id":"716eac4a-ca61-41e9-855a-e9df58569e66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48273","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:e507901a-faaa-4b92-9661-bd045bfad933","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:51","original_object":"UniProtKB:P30939"}
{"id":"15f48959-e041-403d-9d1c-402962ebcf68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25110774","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:a78e1867-c68e-4b8c-ac57-65e5b9ab8b61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9180","original_object":"UniProtKB:P04150"}
{"id":"de2e5fa2-036b-4816-be68-a9c108ebcab1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2210","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:60731b30-d025-4c62-8f73-91425be52ce9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2210","original_object":"UniProtKB:P37288"}
{"id":"25178ea1-aaa7-4dc7-ab84-5fbd8377b2a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817503","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:2f5d5b4d-5947-4189-8414-377f83d7f45c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8525","original_object":"UniProtKB:P35414"}
{"id":"89b4aebb-8e58-4ea7-9dc9-5d887fb24d5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9691","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:67f97330-b092-4aa8-9235-758a83ae3c27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9691","original_object":"UniProtKB:P10721"}
{"id":"c7587a07-394a-4fdf-be20-44963aa060bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:039b9765-0733-400a-abd5-7995dd2ba78c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P19020"}
{"id":"4cf9db8f-3a46-4657-86f0-bc08e8d88df3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49831044","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:4442c2e0-594d-4c7d-82a1-dc1d4bd7de5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7700","original_object":"UniProtKB:P04629"}
{"id":"d1b24430-6d64-4ec5-b017-a8d7390eaa7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2047","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:36d2a01f-72ed-4596-88e5-350944579d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2047","original_object":"UniProtKB:P32745"}
{"id":"6c63a1e3-6717-419e-843e-9403d69aa764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7872","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:a7676910-3197-4fda-8992-2840f97b7af0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2174","original_object":"UniProtKB:P30560"}
{"id":"2ba526a0-5750-46c2-b7a1-7919071e48ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:9ab1902b-1bbc-43ee-8fe3-d469b691e278","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:P00533"}
{"id":"29935fc1-e422-46be-9afe-876d4960222b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:73SM5SF3OR","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:a64d2ace-8af5-49ef-a21e-a5529d171102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9991","original_object":"UniProtKB:O60674"}
{"id":"843c620c-166e-472a-abad-4e0973f46bf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10119","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:97404e61-8552-4e8a-a067-2da1e10d1d2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10119","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"2acd8d77-f6f6-4942-a64f-4c102bb2f07a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:963a057d-7a43-49bd-9e34-df7b71d67e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q8NEC5"}
{"id":"ffef836d-986b-4477-9c70-b4251dbe1c13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3NIO1FB8ZU","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:2ad3d4d9-afe8-4c61-9305-c9207cd0b075","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6425","original_object":"UniProtKB:P31424"}
{"id":"1b9cb53a-223c-4bff-be31-62ea8aa767ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91938094","predicate":"biolink:affects","object":"NCBIGene:259230","sources":[{"id":"urn:uuid:5d03cd55-c540-4047-af4a-20eb007de065","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8835","original_object":"UniProtKB:Q86VZ5"}
{"id":"18e839b4-0dd0-4580-b042-c11d6ad23dd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:3a7e6d6f-eb5d-4f12-9c65-d0c1df23bd7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q92736"}
{"id":"2dd2873b-f43c-4a83-8584-e41a93152e0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2552","predicate":"biolink:affects","object":"NCBIGene:16491","sources":[{"id":"urn:uuid:80274638-1501-4a70-ae03-c9e410619311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2552","original_object":"UniProtKB:P16390"}
{"id":"70acd2a3-8f6b-4a67-a4f9-7c85c29f3685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56844240","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:43e4d88f-4875-48f4-94a3-da2e7878dc62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9236","original_object":"UniProtKB:P29274"}
{"id":"697e5677-8b75-401d-b95b-a7f0f3a02b47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91634","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:6e431e67-b32a-4390-b82a-9e5ff387ead5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1613","original_object":"UniProtKB:P34975"}
{"id":"7318b575-8fda-450d-8c21-9d6b5dd95399","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:2046","sources":[{"id":"urn:uuid:93a3b8f4-9f8c-4065-b7a2-4063eee5740f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:P29322"}
{"id":"1684bc9c-3613-48d7-8a42-54a925ee3179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:3d169c05-0743-4e05-ab67-3a8e7829db0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P28222"}
{"id":"c30c3b4b-4626-4a3b-b863-5bf6ca97c895","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:e682766b-de21-4205-82a2-46e6f6f80fac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4367","original_object":"UniProtKB:P48169"}
{"id":"f1f7699a-e4a8-415a-be63-5857b4dac250","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180876","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:b765ff73-bc51-489b-931d-0b49c3176874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:208","original_object":"UniProtKB:P41595"}
{"id":"5d39ff52-bdd0-4405-9d96-a4444de25415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5841","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:81d5122d-91f5-41cc-91bf-64399b1c6c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5841","original_object":"UniProtKB:P25090"}
{"id":"a9336570-6b8d-4b05-ad5e-3a9779f3b5df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34524","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:737347db-0446-4162-a597-b8a1c02a96f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4124","original_object":"UniProtKB:Q14643"}
{"id":"63d86e64-05c1-464e-aa7c-c4ef5fa38acb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:4f72757f-4e31-4244-a331-e97f310e1a37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P30939"}
{"id":"201e0130-3c3f-4e11-b5bd-5dbe5d562cb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:10052","sources":[{"id":"urn:uuid:8a76f585-b66b-4d9f-ac6a-1e121ff87850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P36383"}
{"id":"d4130ad9-4ca3-4bf7-a9f0-40de2c6bab63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134687593","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:16a8bb61-acf4-4352-a40b-b5e99097075f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8409","original_object":"UniProtKB:P32239"}
{"id":"2c8b692f-4e4b-4d4e-8545-3862894d84bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34662","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:23f02af1-6e36-4545-b5ae-75769a486b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2324","original_object":"UniProtKB:Q9H2S1"}
{"id":"7579a216-e17f-4a80-bf06-92f7c2a44b31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623360","predicate":"biolink:affects","object":"NCBIGene:11091","sources":[{"id":"urn:uuid:52e881ca-2a92-4db1-aaca-02ca1dac0555","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8231","original_object":"UniProtKB:P61964"}
{"id":"d9ceba3c-4131-4212-80ed-0be77fabe087","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JPW84AS66U","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:29e5f215-c484-44ce-93ab-e7ce206fbfd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12223","original_object":"UniProtKB:P04629"}
{"id":"43e08106-73b8-41e9-bbb1-742fdf106f5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M7X64VTLI","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:d36e696a-ed5d-47c6-8606-67dad2175fae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13204","original_object":"UniProtKB:Q9P1W9"}
{"id":"9a5647aa-1101-4ca9-ac26-74983021f539","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64210","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:339f5449-da59-4c85-be03-911586f6148a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2647","original_object":"UniProtKB:P10826"}
{"id":"6374454f-9355-49a4-99cb-449afbc50212","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z25PJ77W7V","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:964af8e5-903c-440c-892b-f8c68303ed28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:716","original_object":"UniProtKB:P41180"}
{"id":"e7161a02-0287-4c68-8cdb-36672dcfdb2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6780","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:65fbe9cd-b8c9-4ab9-9b34-7f27da4ec796","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7227","original_object":"UniProtKB:P14416"}
{"id":"1b1a816b-a79e-4be7-9e49-474eacfd9a90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZN0X0Q76F1","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:c35503c9-5dd1-4922-aaec-ced9b4a9dbbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5965","original_object":"UniProtKB:P00533"}
{"id":"d95e2d0b-e3cf-4da7-a6db-52c1a58dd40f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:5f58326f-9811-4e77-90e3-5886b4692583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P30939"}
{"id":"5fe91ffe-4bfc-4853-a261-cb1564e695ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9831083","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:8526844b-6ba4-4dc3-8bc5-ddc63951ea25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:659","original_object":"UniProtKB:P46663"}
{"id":"482c488c-2a4f-4353-ad37-9ca90f2f1d5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RVW387BA9U","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:267f19da-bc6e-4a66-99b7-4d0a19bfc4ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10004","original_object":"UniProtKB:P12931"}
{"id":"b2a57a93-a800-4028-9d2f-d176364fc6b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91754554","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:61acf62f-7d77-4ef6-9685-db1130857b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8481","original_object":"UniProtKB:Q04771"}
{"id":"2a483c8c-356a-4156-914d-80622d3bc870","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44285668","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:75a35804-e2b8-4b01-96d4-61aac69eb565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7991","original_object":"UniProtKB:P04035"}
{"id":"3a295b6a-20a1-4e61-82ac-cbb6c2f82d9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45951","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:96d2cd63-8b98-4412-8ab3-e54fe311459a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:214","original_object":"UniProtKB:P21917"}
{"id":"dd0c9f42-5251-431c-ac70-3ab3b0d36774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34457","predicate":"biolink:affects","object":"NCBIGene:1186","sources":[{"id":"urn:uuid:069e16f0-b3ca-420c-98cb-ff912dc54e35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4270","original_object":"UniProtKB:P51798"}
{"id":"68bc20c7-ea73-46b4-91d4-22457a77b326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5YL4IQ1078","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:2cd4a554-7a01-4c27-a637-1d0cfc5551a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8310","original_object":"UniProtKB:P15538"}
{"id":"4de80b83-63a4-49cd-b4e1-8fab7d6d9800","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643159","predicate":"biolink:affects","object":"NCBIGene:100359982","sources":[{"id":"urn:uuid:dcef7521-69a0-4717-81c0-0932aca68735","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11299","original_object":"UniProtKB:P38718"}
{"id":"4c7ab92a-fed8-4574-a173-c84d620a842e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:7335eb01-cfa7-4505-9f67-5c7302cfae3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P21918"}
{"id":"f757d24c-6cd0-4abf-aeff-027f3cd8b439","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33206","predicate":"biolink:affects","object":"NCBIGene:358","sources":[{"id":"urn:uuid:297073ad-2b1d-4bfa-b8a9-6d06a2692656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1773","original_object":"UniProtKB:P29972"}
{"id":"7d02c7ca-9667-43dd-82ed-238c4e911960","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:218772","sources":[{"id":"urn:uuid:bb471f21-d864-4bae-b9e5-ec4bb45500d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5383","original_object":"UniProtKB:P22605"}
{"id":"a39b9aa5-94fd-4095-8eb2-ea48b73ca049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93243","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:d5b326a8-6dbd-44ba-bfa5-6663ecc5e387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7646","original_object":"UniProtKB:P04626"}
{"id":"d68ecde2-072e-4cb8-ae1a-efecf5f51402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312396","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:0b153680-08f4-4b38-a335-3bf832e9cafa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12396","original_object":"UniProtKB:O00444"}
{"id":"8cf895c4-b566-4a82-81f6-b43b0c114d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:b32e348a-dc0d-40c2-a1df-770d0d246f9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9HCF6"}
{"id":"086de303-1c4e-4618-befd-bd10ef2c98cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48935","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:5ff1a1fd-93d9-409f-b1c1-d3e361a18cc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1465","original_object":"UniProtKB:O43193"}
{"id":"178b58a0-6c58-4e8a-a607-8a9aee53982f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95030","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:d3e798ab-c179-4ebd-b86f-235eac9484d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5243","original_object":"UniProtKB:O00519"}
{"id":"71bf3de2-44d4-4072-af2b-eddc7b7e2bff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311437","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:f2e1f75a-1f1f-4a13-bdce-7fd50ddc8f97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:498","original_object":"UniProtKB:P25100"}
{"id":"4bfdb945-9a93-4528-98fa-94ef97dfa92c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72201045","predicate":"biolink:affects","object":"NCBIGene:26273","sources":[{"id":"urn:uuid:e038423b-82b5-48f3-861d-f6943d287681","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12671","original_object":"UniProtKB:Q9UK99"}
{"id":"e657150f-67a3-409a-a5f0-311c16110a3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3697","predicate":"biolink:affects","object":"NCBIGene:55366","sources":[{"id":"urn:uuid:a10f882c-e4c3-47df-af55-724cf56e4140","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3697","original_object":"UniProtKB:Q9BXB1"}
{"id":"95bc6ce4-288e-4fbf-9107-f013ee8b035c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231394","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:1eaa6ef3-9d81-438e-bac8-ad44aced9237","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9074","original_object":"UniProtKB:P22303"}
{"id":"b26b7a6f-63a8-4f0c-afbf-311e6b41c7a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:fb4a42bd-b988-421e-a5b7-aedf7b989f4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P28223"}
{"id":"ad76cb92-4d0f-457c-aa67-29de3d20e84f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4972","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:37323c5f-ec16-40c4-ad9a-9b02d335c995","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4972","original_object":"UniProtKB:P08069"}
{"id":"8f2cea0e-fa3b-44b7-8efb-91492d74a6d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5YG6JK4ECM","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:2255be5b-8de9-4214-b1cc-7b601fd2abce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3262","original_object":"UniProtKB:P08173"}
{"id":"a471dd47-f103-4c78-857f-dc3668964c3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44123657","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:e705c73d-5f13-4071-9cdf-858088de1f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7696","original_object":"UniProtKB:P35560"}
{"id":"45e0e1db-8dd4-45f0-8f72-1645392a5721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91754554","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:a4613863-f8f4-40dd-9fc4-640c893a5d0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8481","original_object":"UniProtKB:P36894"}
{"id":"bc45f353-bd5b-4e52-8f78-13396c9f319a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7903","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:b414d9c5-277e-4eea-ac26-af02240ab34b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7259","original_object":"UniProtKB:P14324"}
{"id":"a80e50a2-17df-481a-a06e-ca511fa629f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:72977da0-e2e3-4b3e-9b6d-3de218e09fba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P50406"}
{"id":"a3abfcde-b360-40ac-a4c5-2335c325e5de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:2f7b3df9-730d-41f7-8120-9a28ef50ae42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q14524"}
{"id":"8e2fb36d-1d75-4c3c-acd1-f158079c1491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:05b02113-a650-4cd6-8f6d-c6032f8938c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q99572"}
{"id":"52eb5f64-777a-409d-94cc-620da80f1957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:02a0c6f2-87ac-4ba2-bed6-9d93e07c640a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P48169"}
{"id":"6829d906-d062-4ce2-8253-f0866f2c003b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51450","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:5a26d38a-b153-4a5d-854b-508c6958ed35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3494","original_object":"UniProtKB:P24530"}
{"id":"28c09dc1-35b4-4d82-9b05-339ce73a4994","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132709","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:ff2b4c5d-09ec-483f-b0ba-06eec9e29762","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1477","original_object":"UniProtKB:Q9Y5X5"}
{"id":"f032750a-b51a-44db-970f-c060c8f6cb1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92090","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:d8e25211-c5a0-4e75-866b-6e231caf49e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:177","original_object":"UniProtKB:P28223"}
{"id":"2759d404-f964-4bb1-8e0e-2917340beb49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25105713","predicate":"biolink:affects","object":"NCBIGene:5338","sources":[{"id":"urn:uuid:4fd27d01-08a2-4bb8-a9b6-99da5a3b4791","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8782","original_object":"UniProtKB:O14939"}
{"id":"55372958-52ac-4110-8a47-4ff55951b8e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L2BD0MW4OL","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:2759099b-5260-4e58-9a46-e01827645a3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8742","original_object":"UniProtKB:Q05397"}
{"id":"63b05e5f-b9f9-46ec-b448-cacdf17413e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46229","predicate":"biolink:affects","object":"NCBIGene:171108","sources":[{"id":"urn:uuid:74dc02d6-0125-482c-ac8b-b0a0adb9aaf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1783","original_object":"UniProtKB:O35881"}
{"id":"887dcb8b-64c2-41e3-a8e2-34117cf174da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11721","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:2bc14ac1-555e-4e0f-890d-cc7dc7a1d40f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11721","original_object":"UniProtKB:P11362"}
{"id":"159a2db6-8a1a-481d-aa1a-ef635dd1dfd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9017","predicate":"biolink:affects","object":"NCBIGene:760","sources":[{"id":"urn:uuid:29232879-aef0-4997-bd21-68441ce68d6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13093","original_object":"UniProtKB:P00918"}
{"id":"7723c259-0d59-4d49-a91d-56cd5a185999","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:8c83b2de-bb1f-4c36-b340-bad5b45cd50e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:Q7Z2H8"}
{"id":"b1047e95-2327-4f1b-b9af-0266d0dcc3bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9953255","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:3b45e7b0-5309-49c7-9ae3-247df8db3fdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:378","original_object":"UniProtKB:P30542"}
{"id":"7f4d6dd5-a044-4d78-9d0b-94bd2e77d347","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6780","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:73af1132-09e0-4d87-be1b-26869c35cb8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7227","original_object":"UniProtKB:P08908"}
{"id":"ee09156b-833f-4fd6-aaed-6401347b5486","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9998187","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:c1e1fe2d-f9b7-4f57-8ca4-1fe0dfc10321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1353","original_object":"UniProtKB:P49286"}
{"id":"71bbee87-8040-427d-9fd6-aa1496d2b604","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127948","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:88512e9c-7239-4ee3-b287-c16fc990d064","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:884","original_object":"UniProtKB:P43220"}
{"id":"c9c5a3f2-0213-4aff-ba8d-86aef258e73a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V2GJ2XVK6G","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:cd471e5b-2e91-4abc-ac42-f118fc621ee2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13145","original_object":"UniProtKB:P49840"}
{"id":"909f7877-6ed5-4835-8d2f-a87f22a3bdd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2183","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:92e14170-d2e5-4ec4-9b80-2e08a070ff95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2183","original_object":"UniProtKB:P47901"}
{"id":"4b2ae7db-1fc5-40d3-a92c-d1b1ff76eda3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4469","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:25789d9d-f0de-4671-b324-bea3aaea5330","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2147","original_object":"UniProtKB:P23975"}
{"id":"8e4305cc-8120-4ba9-a5d2-f7ba6e331f3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111162","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:18ef16e4-f74e-4fe7-86f4-b6feff4b5338","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4219","original_object":"UniProtKB:P48058"}
{"id":"7a319cb5-36be-4f21-a2a1-00271810ae3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180876","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:dd1cce65-cb94-4567-a082-434343357059","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:208","original_object":"UniProtKB:P08909"}
{"id":"c0fc13c4-0d36-46ce-bf06-460750fc8c2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32087","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:b9294912-207b-483c-8f89-c7f84e8dec07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1911","original_object":"UniProtKB:P21731"}
{"id":"ce734ec1-5ed8-442b-9d81-188a6593c94c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755112","predicate":"biolink:affects","object":"UniProtKB:P42893","sources":[{"id":"urn:uuid:e2edf9a5-5f32-415d-ad3c-a9f58fa8ab07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5272","original_object":"UniProtKB:P42893"}
{"id":"2fb1d6f2-7957-4495-a6ae-b81bf233fb97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996516","predicate":"biolink:affects","object":"NCBIGene:2825","sources":[{"id":"urn:uuid:92abda14-e6dd-481c-8e7b-bcd01412b449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10573","original_object":"UniProtKB:P46091"}
{"id":"31e649ed-4a27-472e-b752-b28760bc7005","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:97BT14C36A","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:516a9e22-0f2a-43b8-ba59-a4e2f8421e02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:933","original_object":"UniProtKB:P21728"}
{"id":"d7e890b5-cd95-44ef-83c9-ea661f676687","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:79885","sources":[{"id":"urn:uuid:3b4c6315-612e-4ee3-93db-c87a33cc23ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q96DB2"}
{"id":"d8e46cf2-713e-4235-b507-887b3fb44cb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37850","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:6ad2f1b0-4706-471c-993b-14b14b23cc4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2459","original_object":"UniProtKB:Q99572"}
{"id":"f9ad92d5-2818-4909-a77e-6d6342589fb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:63895","sources":[{"id":"urn:uuid:f3275809-b5cf-4093-8328-b61868d7cac3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q9H5I5"}
{"id":"fa81b41d-fc8c-4b72-8af5-950266152e5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9798456","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:e564cf7c-e763-4398-8427-8254fe9d375e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7922","original_object":"UniProtKB:P49286"}
{"id":"a6de2f70-8f9a-4c01-b975-c08099cc6d38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:b18f85e8-ec70-44d6-8881-52f19702e6fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P24046"}
{"id":"214ea042-a292-4296-a75c-5af5e96f9f53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8890","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:3abad8c9-dd19-4837-be7b-e1b5abf7d36c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7602","original_object":"UniProtKB:Q14524"}
{"id":"cfba3f73-9a72-4c50-8389-418b5ece94ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0UPX3E69W8","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:f316e4a8-a268-46f7-971d-ca9e3aea19b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8370","original_object":"UniProtKB:P21728"}
{"id":"8d166074-b1ba-4809-aaca-417cd01b22a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:e18fbb27-248a-42c9-95e0-b1a6327be060","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P34969"}
{"id":"ba5888d3-84d8-4b04-bcbc-39aa541818b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:625","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:b3b798e5-2163-4b7d-907e-d878708427e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:625","original_object":"UniProtKB:P21729"}
{"id":"5ddeb2d9-1380-4a6e-b2dd-d9153baeebb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:758","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:78b8bea5-0423-482f-97df-3e16d42d07ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:758","original_object":"UniProtKB:P32246"}
{"id":"2b3d5f7f-5c9f-4ccf-8a4f-f442565ec9f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:60f2996a-a8fe-42c7-a71b-50a1c3866934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2291","original_object":"UniProtKB:Q9NYV8"}
{"id":"0d3ac098-0f66-4309-9778-264fbf4691aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28411","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:c3233731-d479-4788-95a7-5d52d4416152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2419","original_object":"UniProtKB:Q8BLA8"}
{"id":"350b6108-d57f-4510-97f6-3d0db14cb23a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:191043","predicate":"biolink:affects","object":"NCBIGene:57302","sources":[{"id":"urn:uuid:c08e37ac-6363-4cff-ba0e-308f7e0c3896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12753","original_object":"UniProtKB:Q9QZN9"}
{"id":"3cb09077-0418-45ff-bb99-d5c643817832","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311213","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:4ca577ad-8329-42ec-8336-debf761dbade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1898","original_object":"UniProtKB:P21731"}
{"id":"24e37bb5-4aed-4775-9d08-0a4d4de1f424","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4H1AU2V37X","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:5a447e8e-8f5a-458a-acaf-ddc27ca7f06d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1278","original_object":"UniProtKB:Q9H3N8"}
{"id":"d265bc84-f5d4-4f3d-916f-75e321c2ae43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11501277","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:f1314ba5-fe0d-43cd-80fd-68d90a386122","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2145","original_object":"UniProtKB:Q923Y9"}
{"id":"b6aefdb5-ee80-4a1b-886f-a7ddb3944ce2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78825","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:827afcc2-45e1-40ba-92ed-de5924a3a5c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11867","original_object":"UniProtKB:Q02750"}
{"id":"379b43de-4b66-4b2f-9c2f-d059b4337cb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:ec7b718c-0696-44d5-8ab6-2338313c095c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:Q12866"}
{"id":"c68482bd-adc7-49f6-99bc-915000665fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44577753","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:a66f2b96-1ced-4a98-8c00-6696dfc772ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8121","original_object":"UniProtKB:P37023"}
{"id":"db3abd55-d252-47d3-84a7-d9ba9e94c4bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25172871","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:55cb6ec6-565f-4dbc-b0b5-ab9ad6b4167f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7732","original_object":"UniProtKB:P98170"}
{"id":"bf698398-cd6d-4741-9fb0-3a1cbab09cc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AM9K4SZ3XK","predicate":"biolink:affects","object":"NCBIGene:6300","sources":[{"id":"urn:uuid:c8b0b80a-03e2-460f-b42e-1a51324dfd3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12122","original_object":"UniProtKB:P53778"}
{"id":"1713ef60-89a5-4c27-9644-70c5633aadeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755180","predicate":"biolink:affects","object":"NCBIGene:12209","sources":[{"id":"urn:uuid:88a14356-cabb-4fc3-a3f9-7ea6c55716b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6176","original_object":"UniProtKB:O54798"}
{"id":"8bee830f-d8f3-47a3-9d2b-ed60126ef556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92070","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:10da4fb0-f7ab-4b6f-a36e-1c5f51bf99dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:94","original_object":"UniProtKB:P19020"}
{"id":"908d841e-506a-4030-b4c9-f06860b4ba0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9892288","predicate":"biolink:affects","object":"NCBIGene:38","sources":[{"id":"urn:uuid:1845845a-fdd1-4550-afc3-228dc084780e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10150","original_object":"UniProtKB:P24752"}
{"id":"21208b08-36be-42c2-a59c-a231366393e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93368","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:c2a15d24-c1f3-4618-8b7e-407f75a86a80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:173","original_object":"UniProtKB:P41595"}
{"id":"536d1949-d891-4c86-ad50-e587392c25f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11501","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:b6656772-fb37-47a8-88d7-473f56afcc6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11501","original_object":"UniProtKB:P0DTC2"}
{"id":"3b1cdea0-b532-4c37-92bd-777b04ca6db3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94506","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:09b23c39-87f4-4acd-a9d5-88ab47491c41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5932","original_object":"UniProtKB:P24941"}
{"id":"023065d8-f123-4cbd-bf47-338a2a1e7095","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:26946","sources":[{"id":"urn:uuid:0e1c8998-ce8a-4949-b1ae-7398139d5a20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9WVC5"}
{"id":"56a30536-2872-4423-88fe-8fc183e7605f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10609","predicate":"biolink:affects","object":"NCBIGene:952","sources":[{"id":"urn:uuid:47dbfd05-88a2-4d5f-aca3-5e0e9f8581c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10609","original_object":"UniProtKB:P28907"}
{"id":"4058c3d4-6361-4f9e-9a94-08cb80148b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611888","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:4c20f8e3-3e7e-48c2-a964-3759362b1ed3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9968","original_object":"UniProtKB:Q9Y210"}
{"id":"98d631a3-93da-463c-beea-efedc56d406c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153282971","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:0e82a5de-b43c-4816-bfea-50f40902fcd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11977","original_object":"UniProtKB:Q9NYK1"}
{"id":"0121e15e-53ab-4523-8c6f-79bb78192c0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918854","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:f19a739b-7ea2-4288-a6e4-0d901016409e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2239","original_object":"UniProtKB:P30559"}
{"id":"db7e5445-4ce4-4902-8ede-43746d852d49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NS95DW687N","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:dbe83042-266c-48f0-bf2c-795477c3d43a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2253","original_object":"UniProtKB:P30559"}
{"id":"ba0fa504-0e3c-4270-bdc8-6eb0a25fb2bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73977920","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:2ad1c567-d036-4688-8ed8-a0ed1578435e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5598","original_object":"UniProtKB:P30542"}
{"id":"38b73249-ec10-4f03-b610-041c13cf1269","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:beab2cdd-0207-4157-b2a3-a2e09fc449a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:Q9NRM7"}
{"id":"80b760d4-a81d-45f9-87e5-9a79761e3a21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42142","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:d255b348-dc42-458d-9be0-38dfeda6aed0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8760","original_object":"UniProtKB:P00734"}
{"id":"6daa54b2-aaee-4c05-ad68-cd3a39bfb3fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53323295","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:ef6582e5-9deb-4316-b7a3-4f689c24527f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1077","original_object":"UniProtKB:Q9Z0U4"}
{"id":"b1675eb5-c712-4ce5-97bd-bd19ed56a849","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755025","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:62732e80-b162-4534-b889-b641587a47d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1983","original_object":"UniProtKB:P21731"}
{"id":"79add308-7292-458e-b493-22d59a8f01dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36795","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:12f7d035-f903-4dbf-b11f-12253d8e6add","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:202","original_object":"UniProtKB:P31645"}
{"id":"0cc41927-cb7a-4981-b310-e3180b9eb7cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8GU4PSP29","predicate":"biolink:affects","object":"NCBIGene:5136","sources":[{"id":"urn:uuid:63050263-bb9e-4b02-ae02-8f617dac36ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5270","original_object":"UniProtKB:P54750"}
{"id":"52a8d6c1-a3c3-451e-a06b-c37d5cbb07b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817473","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:6b93074a-0f26-4adc-9642-4a077bbffbea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6084","original_object":"UniProtKB:P47211"}
{"id":"61d3db7f-a000-47fe-bb95-9c2196141854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103931","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:3cc84b8f-89d2-45ea-8eeb-b70756ca00b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:487","original_object":"UniProtKB:P35348"}
{"id":"2893b53c-da83-4644-b09e-9ec5b848809f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:237657","predicate":"biolink:affects","object":"NCBIGene:6506","sources":[{"id":"urn:uuid:cec88b7f-8249-48a6-a2b5-dbe799a09dcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4573","original_object":"UniProtKB:P43004"}
{"id":"9bf5de1b-fbf4-4682-b1a1-4b2875bfea54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10411224","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:829781e0-5f34-4299-ad46-403335658262","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3108","original_object":"UniProtKB:P37268"}
{"id":"f914bc73-a9d5-4ccb-a5b3-9c3cc7026870","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90844","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:eb62f604-19d4-4255-af2e-3ebbb7267292","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7552","original_object":"UniProtKB:P43119"}
{"id":"aecae4db-95e4-4f74-b0df-db940f3dc04c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4283353","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:640c01f9-90b2-4c6a-9867-4b1356ee9e11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10131","original_object":"UniProtKB:P30530"}
{"id":"d9b61ab3-1a63-46ac-b4aa-95a88a03b7c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40953","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:04fe6e58-37e1-4b88-94bd-9d15734bdd28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5668","original_object":"UniProtKB:Q16539"}
{"id":"03313b1c-0102-425b-8ecc-62a4892b58e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98BSN6N516","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:c484e622-d226-4218-981b-0e8bc9b863b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9789","original_object":"UniProtKB:P22607"}
{"id":"49270f09-dd63-41a3-8f32-f63abb8affae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232381","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:04bf7f08-ed0d-4c9f-ad05-99725df99b8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9355","original_object":"UniProtKB:Q12852"}
{"id":"6cd0dfd8-9cc0-48c2-b47c-ffad0f09e4a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98Y1I8ZD4M","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:9f34e35b-a761-4fab-b3b7-02323da0a080","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4082","original_object":"UniProtKB:Q12879"}
{"id":"4132e7e2-d87c-4c6e-b723-ba9c1244badb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:f29abbce-8047-4c03-bb38-9f1e7ed39d30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P28221"}
{"id":"81cc955e-76dc-4bdc-952c-829431f3c202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:65180","sources":[{"id":"urn:uuid:67d6b082-8bb9-4120-b3a2-e518233e61b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2391","original_object":"UniProtKB:Q63881"}
{"id":"792e9e57-e077-41c2-87bc-d2f3bd08970b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34898","predicate":"biolink:affects","object":"NCBIGene:21898","sources":[{"id":"urn:uuid:e76386b3-eab4-4e63-8788-27e6081b50bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9024","original_object":"UniProtKB:Q9QUK6"}
{"id":"04836a9a-5e30-4ae1-9fff-3dbc2e72132b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755223","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:c7c765db-6de3-4aed-a417-6557c16b48ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6446","original_object":"UniProtKB:P31424"}
{"id":"e1f31d88-f4f8-4da4-a43b-d250cf2d1f50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53377584","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:97d5cb60-84c5-4eba-8bde-7832282e1e85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13406","original_object":"UniProtKB:Q6RI86"}
{"id":"8b75bb75-9787-45a5-99b7-7b44d1daf4cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1998","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:031c75a1-04b4-49b9-b3f6-4ee760a2e953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1998","original_object":"UniProtKB:Q8TDU9"}
{"id":"e6d6e3ff-95da-48cc-9dca-093a9812cb9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92916","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:d64e82c3-572a-4b2b-bba6-434285469a83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1922","original_object":"UniProtKB:P70597"}
{"id":"24a2795d-e20c-45c5-a756-f20d2dceb5d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27690","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:d1c4ef34-c2ad-4d55-9683-963badafc402","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6792","original_object":"UniProtKB:O43570"}
{"id":"a2ceabec-9ac7-4e9c-a206-add6477ded72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44561595","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:4011193e-7ffe-4a38-81a5-e03aa13735ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10057","original_object":"UniProtKB:Q96P20"}
{"id":"42f2b981-3301-456e-b112-b2d556f7b34c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135332280","predicate":"biolink:affects","object":"NCBIGene:2145","sources":[{"id":"urn:uuid:9e3181fd-da36-450b-9e3b-99320f65d3a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13512","original_object":"UniProtKB:Q92800"}
{"id":"c5dea08d-0899-4368-ace8-ca1ae438ae10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817475","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:cba17587-1cac-4842-b2c0-f1de56ab48d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5359","original_object":"UniProtKB:O08726"}
{"id":"d9705223-b3a5-49e5-8d27-e0650a9ed0d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95061","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:793c4f60-a5fe-4e2e-a296-f71363789bb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8784","original_object":"UniProtKB:Q9P1W9"}
{"id":"177ff761-da89-4eb7-a5e6-81b602fda68d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5HNG5UF2U","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:4b2719ae-7644-4ea2-bce7-6ec127c6d1ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11885","original_object":"UniProtKB:P06493"}
{"id":"924f6f7b-f743-459a-8fbd-872df814c83f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:1b2feaa9-457a-4b4b-8372-eb02f47a5aec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:Q62805"}
{"id":"63a03520-5d77-4250-8982-7097d347acfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5558","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:e80f9832-cff8-448d-8f37-80937f0e06d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:522","original_object":"UniProtKB:P18089"}
{"id":"9b764b3a-3780-45b3-b02e-74a71f9f7858","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135261","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:ff1e0375-e55a-42de-bc6a-8e790a1ca30f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:569","original_object":"UniProtKB:P26255"}
{"id":"001ea7b8-7ff3-4d0f-b178-aa4fbee07b6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:65268","sources":[{"id":"urn:uuid:fb3208c7-a102-4ae8-80b0-49ae2e2de5e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:Q9Y3S1"}
{"id":"ccb992b1-e279-40f6-8990-d040f318f6a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65173","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:02e6cdf5-924e-40bf-a32d-fa34dc7873d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:87","original_object":"UniProtKB:P61169"}
{"id":"fa15e081-6d8a-47eb-b0ef-419e13427b11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154677753","predicate":"biolink:affects","object":"NCBIGene:9448","sources":[{"id":"urn:uuid:f9bd5b59-777c-41c0-87c9-0c857a4cf0e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13267","original_object":"UniProtKB:O95819"}
{"id":"e1a641e4-9d34-4685-9d92-f30136d1d176","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2187","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:cfae424f-d551-4d48-8726-c4662f0c15d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2187","original_object":"UniProtKB:P30518"}
{"id":"19b1681d-a830-4b48-8a37-ddd683660e7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49843739","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:aa22c275-06e8-4e49-bb9a-c0a7a971a0bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8867","original_object":"UniProtKB:P35372"}
{"id":"ec9d7f15-4c43-4d37-806f-685257cf69a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82644","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:1d5318e0-02da-4878-b92f-bee16b6a6c0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10455","original_object":"UniProtKB:Q923Y8"}
{"id":"bf26de0f-5ed0-46b6-8a62-e5c030b0ca28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:9970","sources":[{"id":"urn:uuid:0862ace9-f856-4b2b-96ef-590dad2b5cae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2330","original_object":"UniProtKB:Q14994"}
{"id":"7255ff7f-9fe2-4d5a-8f06-ae7ead75ab9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4323","sources":[{"id":"urn:uuid:a7a27066-c5ce-4a1d-b98a-828cdac080ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P50281"}
{"id":"e1ae107f-4374-4bfd-96da-9f019d1702c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17698","predicate":"biolink:affects","object":"NCBIGene:259287","sources":[{"id":"urn:uuid:26866fd4-c6e4-4efa-ad56-41a20e85f002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10901","original_object":"UniProtKB:P59536"}
{"id":"5248b211-280e-48ae-9f71-5cfacc87834f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88219","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:72ebc74d-7c65-49af-b0b5-ee6a1be5e3ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11134","original_object":"UniProtKB:P36888"}
{"id":"2e5f5dec-e3de-4e81-8b39-550724523077","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93403","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:1774730b-37fa-4379-be02-bf4ab3cff156","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9215","original_object":"UniProtKB:P21917"}
{"id":"5a4a14bb-eca6-4865-8566-c2d64cccc6c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10119","predicate":"biolink:affects","object":"NCBIGene:20274","sources":[{"id":"urn:uuid:e01fe628-1ebd-4d77-8ad9-bbc457b20968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10119","original_object":"UniProtKB:Q62205"}
{"id":"2236d7ed-7fbd-4196-b520-e9c0e847926f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6PJC3KPK6S","predicate":"biolink:affects","object":"NCBIGene:170743","sources":[{"id":"urn:uuid:3b6c8f6a-db43-452b-9bb2-634697378133","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9025","original_object":"UniProtKB:P58681"}
{"id":"c9ffd97a-f4ae-4f4c-809d-f7a4edd81855","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GKF8S4C432","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:39a97a02-9fdf-486c-b2d0-cd1a94398421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9601","original_object":"UniProtKB:P35968"}
{"id":"76f93c4f-8bd9-461f-a534-2c20596c8ca2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6950","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:a0fe01c4-6837-41cf-b00e-5c763409bfe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7241","original_object":"UniProtKB:P08913"}
{"id":"da3e3711-0d84-4c41-9ea3-b8f235f94f1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7ON53PV45J","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:06e7f2f6-1153-45f5-ae80-b94af5246072","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13016","original_object":"UniProtKB:P24530"}
{"id":"b6fbceae-4a39-4671-8074-fbc49489bb95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:817","predicate":"biolink:affects","object":"NCBIGene:51554","sources":[{"id":"urn:uuid:9c24ae09-f10d-4df1-ad9c-2c222536270f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:817","original_object":"UniProtKB:Q9NPB9"}
{"id":"700c9a7c-418e-4a16-bad3-39f5933b222e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:226a6aa5-6894-45b3-ac3b-fe1c652c81d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P28223"}
{"id":"3d1111d0-d52e-4bff-9a04-b3cfa6c01616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:c1c4a6a0-d05b-4bbb-96cf-97640604df6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P11229"}
{"id":"ebff2daa-fbcf-4221-b3f9-7373b458bcef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PNM9E64544","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:b201a0af-1fc0-44ca-a192-6f6203cc8169","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"non_competitive_antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6940","original_object":"UniProtKB:P56817"}
{"id":"1b22a14c-87ff-450e-8620-f5b6479bc206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3G4GVP38EC","predicate":"biolink:affects","object":"NCBIGene:121278","sources":[{"id":"urn:uuid:197fc19a-a2cc-4aea-b215-c497aca7d09e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5095","original_object":"UniProtKB:Q8IWU9"}
{"id":"9fe2a99b-bda0-4baf-a2fb-f4c16823eba0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8985","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:e45f1be6-8b09-418f-8233-1c7f44d80f3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11745","original_object":"UniProtKB:P08183"}
{"id":"95d205d2-202f-4233-b363-4bcb7d1708df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4798","predicate":"biolink:affects","object":"NCBIGene:1312","sources":[{"id":"urn:uuid:d8c60325-04a8-4336-ba93-90e6697fcf4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6647","original_object":"UniProtKB:P21964"}
{"id":"79785951-fedd-49d0-be0a-8e8c989b9e5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8GU4PSP29","predicate":"biolink:affects","object":"NCBIGene:27115","sources":[{"id":"urn:uuid:14022ef4-3122-4924-920d-2bd7c24d2fd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5270","original_object":"UniProtKB:Q9NP56"}
{"id":"a358dea1-902b-47ae-98bc-b6c31f943697","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X4D0G881CN","predicate":"biolink:affects","object":"NCBIGene:27159","sources":[{"id":"urn:uuid:4098feda-0a8b-4061-8e26-10d7ac8a11ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11617","original_object":"UniProtKB:Q9BZP6"}
{"id":"59450aad-10b1-4ed0-8d5d-d50755d41bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9086","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:922c50b3-f922-4246-9783-0a8924e34827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6639","original_object":"UniProtKB:P21397"}
{"id":"f95c1aac-5bf2-4950-8bf5-bf0f9d186400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6710","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:06eed87c-f47b-45c4-93cf-414202f6c281","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7219","original_object":"UniProtKB:P35354"}
{"id":"6b5168d4-0838-4b55-b30e-75a28a756a94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149226","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:ec7d1264-a663-4fcf-8934-36afc3d5ca93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:557","original_object":"UniProtKB:P13945"}
{"id":"ec1a7304-4a9f-4521-9ea5-fab877094e10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:1629ad29-9ddc-4264-9a6f-f6e9cf99e412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2291","original_object":"UniProtKB:P48167"}
{"id":"05fb1dc3-0ea1-4e5d-aa28-c04201d66a8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5327339","predicate":"biolink:affects","object":"NCBIGene:835","sources":[{"id":"urn:uuid:a90181be-8206-44c8-b962-bf5d22a2a2df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8628","original_object":"UniProtKB:P42575"}
{"id":"57adeca9-a881-4ab2-a083-f3a20b33e253","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311437","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:079bd3f3-f48c-445e-adaf-d9778c7e5cc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:498","original_object":"UniProtKB:P35348"}
{"id":"bfdfb77c-5945-4315-8e6d-2874869d56c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230500","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:4fe9e61d-d3d0-4e67-9e25-922ce647ba15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8052","original_object":"UniProtKB:P50613"}
{"id":"2417ee96-b3f0-4be7-afc6-d42ba8240a7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3786","sources":[{"id":"urn:uuid:f6861479-6ccd-4097-82c3-5e505aefc043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:O43525"}
{"id":"3f7ad725-3f67-469e-95a3-e4968514e80a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3611","predicate":"biolink:affects","object":"NCBIGene:25570","sources":[{"id":"urn:uuid:bd971855-247a-41c0-bfe2-2896eb5a4725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3370","original_object":"UniProtKB:Q01717"}
{"id":"e47a5a45-1073-4126-acb2-bab5811938ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J0035E9FT","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:bba4e17d-da0a-43b8-9ccc-b0e42a5f5649","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12754","original_object":"UniProtKB:P21554"}
{"id":"24004ccc-1137-49a8-8bed-2d0580d8bcc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85966","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:d901aef4-3972-4ab7-9a2f-9ed0516ceac6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2357","original_object":"UniProtKB:O88703"}
{"id":"9672c639-c101-4616-a617-90dcd2bcaf8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122173996","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:076a97bb-feed-4bc7-b729-8e19a1933bec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9317","original_object":"UniProtKB:Q9UGI6"}
{"id":"6a649975-8af7-4e2e-afa4-1e70cefe4d83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5HNG5UF2U","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:11bfa052-9cb2-46dd-8368-b71dc7202dfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11885","original_object":"UniProtKB:P24941"}
{"id":"c9b74574-ae63-4a7f-8438-62025319291e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155409732","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:208fb225-1714-4590-ab1b-13913aa6d2d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12277","original_object":"UniProtKB:P24941"}
{"id":"8860c1b5-d303-4e23-8f85-c31f195ae635","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145997911","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:680191ee-1a59-43d5-8b23-59f24731bf35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12528","original_object":"UniProtKB:Q9Y210"}
{"id":"18e4e254-ecaf-4c3d-aa28-c925d2d00bda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233005","predicate":"biolink:affects","object":"NCBIGene:12747","sources":[{"id":"urn:uuid:0e6e8972-64e9-4584-96b6-805e3466efc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5942","original_object":"UniProtKB:P22518"}
{"id":"3f1b2e91-ef17-4233-a02e-44d8b4105265","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59414","predicate":"biolink:affects","object":"NCBIGene:64127","sources":[{"id":"urn:uuid:649f3a66-2955-4992-8163-0349144806f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5024","original_object":"UniProtKB:Q9HC29"}
{"id":"2103d766-b9d9-4640-813f-5057469e8cf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NF3P9Z8J5Y","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:b61175e9-3d00-460b-9712-44a2d3b705f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12362","original_object":"UniProtKB:P19099"}
{"id":"a758381d-5525-45ae-92d4-623777b53435","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:929","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:2bb7ba1c-cafb-4c82-931b-59916f0d861b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:929","original_object":"UniProtKB:P47866"}
{"id":"c77aa02e-81f7-4add-a6c7-8d8464e074f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4469","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:01a314cd-0d4b-4d2e-875a-aed60d893e72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2147","original_object":"UniProtKB:Q01959"}
{"id":"a4d35a52-d8e4-4acd-8c9d-389cd31f9cd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44351001","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:f750276f-ed89-414d-bed6-1f00d8f9ace4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1507","original_object":"UniProtKB:P21555"}
{"id":"01761ef8-b995-43db-826f-edf893e37bfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1873","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:077caf2d-1169-42bb-8359-f3ee7ed2a941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1873","original_object":"UniProtKB:P49683"}
{"id":"53417c49-e0d3-4ec0-9b50-803bc6537413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10124389","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:2063ebc2-2a2a-4f91-8d3e-943ca8a07cff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2175","original_object":"UniProtKB:Q00788"}
{"id":"c30c96a3-697b-47f9-8745-15c006b10207","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3843","predicate":"biolink:affects","object":"NCBIGene:25007","sources":[{"id":"urn:uuid:8235977d-56f3-4061-ab9c-a55d45f01940","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3843","original_object":"UniProtKB:P16610"}
{"id":"fa914872-15e9-447a-902d-3bdf0c362589","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13451","predicate":"biolink:affects","object":"NCBIGene:9180","sources":[{"id":"urn:uuid:99a54fed-44a5-4848-8b91-db5ad86cd071","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13451","original_object":"UniProtKB:Q99650"}
{"id":"698b5031-cc9a-4161-8a0b-7720a9c16e86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9555","predicate":"biolink:affects","object":"NCBIGene:3615","sources":[{"id":"urn:uuid:55967d3b-90a5-437b-a701-ac224d6a3964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6845","original_object":"UniProtKB:P12268"}
{"id":"87460990-ead5-4c26-bcc4-da20e93da18e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92215","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:abaa7481-0841-4fca-a460-5606c37f4753","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2919","original_object":"UniProtKB:Q9HC97"}
{"id":"4e44fadc-763d-4136-a5f3-24b04e8bb301","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9137","predicate":"biolink:affects","object":"NCBIGene:65195","sources":[{"id":"urn:uuid:aad526cb-e36a-4dcd-b055-df5f1dc4d8a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2586","original_object":"UniProtKB:Q62897"}
{"id":"8137e84a-62c7-482d-8810-19c3dbc6891a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:5261","sources":[{"id":"urn:uuid:6d990db6-00c4-430c-b717-4abdeb91dee2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P15735"}
{"id":"fe47643a-2544-414c-9f66-c3a018cb5931","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZH1ZWF5Q3P","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:64a4dcd3-554c-4471-aac1-682a5a238800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3257","original_object":"UniProtKB:P08912"}
{"id":"35385ba8-cee1-40a0-9201-f96e84aaff96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:150189198","predicate":"biolink:affects","object":"NCBIGene:9123","sources":[{"id":"urn:uuid:0bd19898-f1ed-4c7e-bc3f-00a0c8e1a942","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11735","original_object":"UniProtKB:O15427"}
{"id":"fd55f9a8-3137-46a6-bffa-a375de297e51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4NVH197M39","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:06a50efe-ded3-4925-b275-f027e4cecb1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5774","original_object":"UniProtKB:P29371"}
{"id":"8ac0ca88-4c8d-4c16-8b90-58e4356c1721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24944925","predicate":"biolink:affects","object":"NCBIGene:9064","sources":[{"id":"urn:uuid:96c795ac-c314-4053-a586-ebb7cc4b62e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8133","original_object":"UniProtKB:O95382"}
{"id":"752a40f0-188d-46d7-bc00-8f44ac0232ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:7b9e3d87-801e-46c3-8928-a9d021253074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:O88626"}
{"id":"bf631d40-ff18-42a2-bc36-171d7172cc9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:2eae25f6-2b52-4d4b-828c-e2989b6e711d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:O75762"}
{"id":"cc5b8bdf-2e0f-4a33-94cf-9837a988508d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47458","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:3ae6ae6d-a13e-4077-a578-9f9db152ae28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7731","original_object":"UniProtKB:P06239"}
{"id":"185a5b29-f102-44d2-9a0b-d066f0c731c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6539137","predicate":"biolink:affects","object":"NCBIGene:85397","sources":[{"id":"urn:uuid:7019a7ad-6fe5-42d0-8393-25bc77914538","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8033","original_object":"UniProtKB:P57771"}
{"id":"cbaea140-a1da-4e4c-8e3c-00571b167741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31317","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:749e7894-67c8-40ce-adae-bca5cac1ddc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7498","original_object":"UniProtKB:Q9UBN7"}
{"id":"607b595e-63aa-4538-839f-4866a8d7ce5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X46FC5N190","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:f6837d19-5115-409c-8f8f-add433b22b36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4209","original_object":"UniProtKB:P42263"}
{"id":"2f26ca04-bf2c-4cb6-a645-3b1a0e1784ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WFG29AB872","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:433f920e-3f8f-49ed-946f-19765ade2ac1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9928","original_object":"UniProtKB:P48736"}
{"id":"55609bec-04b3-4986-acc1-1087d9f602d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918513","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:0cd2ddb9-363d-448e-adfa-6bf9ae7311d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12","original_object":"UniProtKB:P28221"}
{"id":"c38336da-062d-44f4-83a1-c24391e4c663","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231366","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:961eaeb8-f81b-450d-b800-10bf1754a5a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9911","original_object":"UniProtKB:Q02750"}
{"id":"9c710711-c9ba-4b75-b7ad-0b7117d2f2a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24863112","predicate":"biolink:affects","object":"NCBIGene:10783","sources":[{"id":"urn:uuid:65e61159-1731-4192-8883-c5f44acefb3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8205","original_object":"UniProtKB:Q9HC98"}
{"id":"c8392044-b150-40ef-a8c3-e11cf86e168e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43876","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:fe96d9b6-dc38-4a2b-90ab-c7115c52eb8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1373","original_object":"UniProtKB:P31421"}
{"id":"283c5c48-0a97-41d4-8d8f-64fa4db35e8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132990929","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:5317b4a3-6d18-48dc-b156-876343b5afe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10726","original_object":"UniProtKB:P35372"}
{"id":"b649f7cf-260a-4154-90fb-9489cdd69286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229649","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:e36d5231-80ec-4c0c-9066-085bdc8f71c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9424","original_object":"UniProtKB:O00329"}
{"id":"e52d6d29-c12d-4fc3-906d-eb4677041a02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177450","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:0e34af18-bdb1-4b3f-8be2-fedfbf90f076","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2717","original_object":"UniProtKB:P37231"}
{"id":"62bf6609-97b1-4d85-ab93-1b1759fc5ec7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31638","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:365d82cf-ce2b-4be5-a7cf-5c225fb99a64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1015","original_object":"UniProtKB:Q92731"}
{"id":"90a9273d-18d6-483f-9149-f91df81a2b9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:56R994WX4L","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:76c0d149-1cce-4bde-a5c7-d3622943b26b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7839","original_object":"UniProtKB:O60674"}
{"id":"dba2e6af-1d65-4899-b4f0-4afe4f332ab2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1808","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:44f4eba0-ec60-4d07-8f89-515726d5d4b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1808","original_object":"UniProtKB:P49190"}
{"id":"3e161f61-7756-476b-b7ce-678edbfd6097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:265ade9d-33df-45dc-930b-8dfdaaa6a9e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q9UBN7"}
{"id":"b67eb8ed-3e72-44a1-ab88-2c863fba64fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EK8WS2OJX0","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:165ddd63-a359-40de-bde1-c33d2f179cbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9889","original_object":"UniProtKB:Q9H228"}
{"id":"5d1658c7-4069-4274-84bd-ee58fe045248","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:7837897c-d418-4657-a354-03abaef97756","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:O14965"}
{"id":"8471354d-fbe6-4d20-a5c7-4e982ce21304","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133013","predicate":"biolink:affects","object":"NCBIGene:117559","sources":[{"id":"urn:uuid:3add8776-36c3-4258-8043-a3cbfd13f358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9041","original_object":"UniProtKB:Q02563"}
{"id":"8566bfb4-277e-402e-a18f-b4b75a4f8c8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:108147","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:986ca2ae-5f8f-4ec7-b09c-266542f27e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2127","original_object":"UniProtKB:P29371"}
{"id":"bd444997-4f43-4e9a-81c7-2900d17e2754","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73389638","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:de89044b-e2fd-4043-9cdd-67f6c2eca4a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9761","original_object":"UniProtKB:P51813"}
{"id":"cfbeabcf-ab29-4952-859e-d3822b801bc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6954180","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:73857e81-da36-4fcb-920b-8b5b05557a17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:286","original_object":"UniProtKB:P20309"}
{"id":"0c14fc4c-6c3d-483c-af43-8358b97fd7f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8899","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:97121477-2986-45aa-a868-f6d153100219","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2611","original_object":"UniProtKB:Q12809"}
{"id":"16558767-2155-446b-a828-19e9a29a212b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9953255","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:47a32d3f-fdcb-4dd2-98d5-b7bff6590c17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:378","original_object":"UniProtKB:P29274"}
{"id":"756d0176-7804-4c7e-997c-2db2978ab428","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188680","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:a7835993-1d72-40b9-86f4-0e27c96565b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4587","original_object":"UniProtKB:P31639"}
{"id":"ba1fee7a-770e-4055-bffa-df4add7e79a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030520","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:24f605c9-d081-4163-9aa9-6361c89c413e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10428","original_object":"UniProtKB:Q08881"}
{"id":"2714061a-7d1b-4c11-a9c6-fade705dd954","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J57O328W4W","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:76541fd5-1d24-4d91-ae1e-90b61b70ea53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2307","original_object":"UniProtKB:P56696"}
{"id":"9f0711ea-5120-40a0-b5fa-e79d9b429c7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:560ee47f-05f0-42f4-a0e5-f15e64e27f2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q13547"}
{"id":"36330052-8662-49a2-9242-0b7fda76d4dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:b87bdc1e-58d5-454d-9007-68a923732bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P34969"}
{"id":"7621cc5f-1313-439b-ba90-9ea86f37a493","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169167","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:9e2f4eed-8d39-4ed8-aaab-71934be54771","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12465","original_object":"UniProtKB:P59534"}
{"id":"a927c42a-5f71-4a1e-89f3-944f42190796","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8R4A7GDZ1D","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:c09c9e97-8e26-42fd-9c12-81407c0d2362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7034","original_object":"UniProtKB:P25440"}
{"id":"7421a7c5-bf52-4e6f-9b34-b7efc140c288","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030518","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:9c1054ba-9480-4edd-b802-03b257522f6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10420","original_object":"UniProtKB:P09619"}
{"id":"96ae6d25-509b-4158-b44a-2e31f5ac005a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:447458","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:ae395a4c-6769-405d-bc2a-5006689e70c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2664","original_object":"UniProtKB:P37231"}
{"id":"89916691-dd52-47dd-b237-f882a981c935","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229649","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:77897940-3591-43b4-accb-8f3bae3a3275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9424","original_object":"UniProtKB:P42336"}
{"id":"60054d37-5a1c-4817-ba90-1ffd53400172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2PRJ7DX38T","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:1b493b4e-8f6c-46d2-9220-ecb7a16b1f44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12708","original_object":"UniProtKB:Q9P1W9"}
{"id":"5e493fcf-cc2e-4a67-973c-a53f299c9d3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132986","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:e4353946-9377-41d8-9a37-006bccb47a1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7717","original_object":"UniProtKB:P04626"}
{"id":"30f433ca-b736-4b2c-bb36-c9cdc8185e4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162641136","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:74c22b26-0563-4b93-966b-406d3bd12f00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11927","original_object":"UniProtKB:P43220"}
{"id":"1c98e7ef-838a-4d4b-9938-f14718bcbd58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5070","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:2d2599d0-39e2-47df-bcb6-100cc112c75e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:408","original_object":"UniProtKB:P25099"}
{"id":"f649be3d-af24-482c-bd7b-5c61e107ce2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127052870","predicate":"biolink:affects","object":"NCBIGene:51752","sources":[{"id":"urn:uuid:e2a7a870-bd18-4f4f-b047-013b8e7ab4ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9683","original_object":"UniProtKB:Q9NZ08"}
{"id":"8b44deae-0596-4478-8bce-1269abd1a604","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N824AOU5XV","predicate":"biolink:affects","object":"NCBIGene:2690","sources":[{"id":"urn:uuid:3b573d93-9aad-4e71-834e-7c53988fca50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7485","original_object":"UniProtKB:P10912"}
{"id":"e78bc787-26e2-4124-87b6-0aab0243902a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1499","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:d7f1ba02-b0b2-4bc4-b270-fae4a318c6e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1499","original_object":"UniProtKB:P48145"}
{"id":"36c1ff8a-b5e8-4823-ab88-721145898539","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15467","predicate":"biolink:affects","object":"NCBIGene:3157","sources":[{"id":"urn:uuid:7020a0a7-5ed9-4439-9fb7-2d67681eb0a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3040","original_object":"UniProtKB:Q01581"}
{"id":"d1771b5b-621d-4698-bb14-bd000e37c1c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918513","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:421f9001-142d-4ef3-aa5c-0db5dc0f8b90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12","original_object":"UniProtKB:P08908"}
{"id":"6820f677-d6bb-4b97-b513-b80e7458efcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36773","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:fab8e0dc-9ea8-4ab0-82fa-5bd29d1559ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2422","original_object":"UniProtKB:Q8NER1"}
{"id":"53831e83-8fa5-4ed3-b783-c29f73929b6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:2364e450-efa1-4d55-af99-6e9f10c36619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P23975"}
{"id":"d54571cd-4c77-4458-9d06-882eb55594ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138455182","predicate":"biolink:affects","object":"NCBIGene:10927","sources":[{"id":"urn:uuid:99ffb450-9f10-4f51-9bc3-cce345267538","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13300","original_object":"UniProtKB:Q9Y657"}
{"id":"f8725d53-65bf-4bc8-9b6f-1ecaec9389d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2040","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:25c6d6f4-66c9-49d5-81a0-a28df7d0bd57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2040","original_object":"UniProtKB:P31391"}
{"id":"10456e2f-2e04-44eb-8cd2-592260cb7ce5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:3221e830-0c0f-43e6-9b50-fd1096ec9cf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P21728"}
{"id":"7abedb7c-ca20-4e4d-bc1a-cc3cf3b5506b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9768","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:5375af4c-f34b-4c3d-af34-d4a53b3af26b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8224","original_object":"UniProtKB:P14902"}
{"id":"3387cfb4-1e4e-43c8-848a-e6d00e54819e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86582973","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:6b935a83-145c-4bb5-a99a-8d5f890ed77c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10584","original_object":"UniProtKB:P22303"}
{"id":"544a4c74-8acc-43c3-a63d-42ba36e12db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31883","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:c7236751-1a2a-4702-981c-636a30bf5400","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5552","original_object":"UniProtKB:Q8TDV5"}
{"id":"79d7dec0-5325-4729-84a6-f1a245b3e7b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:31M3WLJ3KG","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:c149a3c2-6054-4160-8fc9-1e5694c7a798","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11544","original_object":"UniProtKB:P15056"}
{"id":"ab339f44-bb42-4938-b6cd-ec9c59a32908","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E2Y97PQY3A","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:8246db2a-11a7-430d-9f2a-120afefbfbb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11293","original_object":"UniProtKB:Q9QYN8"}
{"id":"90ca77c5-3009-476d-805b-eee04b1125b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133021","predicate":"biolink:affects","object":"NCBIGene:4170","sources":[{"id":"urn:uuid:05eb3f5f-af34-4a82-8bb6-14c30ee29db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8318","original_object":"UniProtKB:Q07820"}
{"id":"e2acd027-d069-48aa-af97-4336a9fe115e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7T1PY32ZPH","predicate":"biolink:affects","object":"NCBIGene:1198","sources":[{"id":"urn:uuid:afa4cf3e-c491-48f5-a21a-da2a13ccf738","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12620","original_object":"UniProtKB:P49761"}
{"id":"81327f2b-0db9-4ced-aeae-879341ff5c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1044","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:bc7f53f9-82f1-4ef6-bdcc-28800f95cf86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1044","original_object":"UniProtKB:P21462"}
{"id":"c6cdb9d4-321a-493e-8b5f-fdfd9a54db5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287532","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:8722868f-ddb3-419d-beda-18c0642153b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11713","original_object":"UniProtKB:P56817"}
{"id":"97eaa886-2407-4396-870c-5f3fc1389e52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70778","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:db7df236-d2f6-4b31-811d-2905fbd15e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2674","original_object":"UniProtKB:Q07869"}
{"id":"147f9d9e-9810-44b9-a528-0b53c089d462","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57340639","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:5828161a-a863-455a-81e4-331fefbd042b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4283","original_object":"UniProtKB:Q8NER1"}
{"id":"469e5630-960e-4c4e-873c-dbdb4d615d29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3840","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:9d36b353-dceb-49ac-afa6-f980fe6987cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3840","original_object":"UniProtKB:P28336"}
{"id":"c82f7e9b-4d8f-4d25-8d11-b3a60b221362","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177647","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:9f34dbc8-ad76-415c-9312-b4aaa9e1e9ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5604","original_object":"UniProtKB:P29275"}
{"id":"dd1de956-d845-46ed-bf17-45d702b876c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28125","predicate":"biolink:affects","object":"NCBIGene:54207","sources":[{"id":"urn:uuid:d286cf85-e016-47cb-85c3-3fc1e52f6ab6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1051","original_object":"UniProtKB:P57789"}
{"id":"180f97a5-4b04-46f6-9013-b8cf6924ea6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:ff22989a-5608-4e37-86bf-51b8e15bf7a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:O60674"}
{"id":"96d3e353-5790-4e38-9227-53985e952ffe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NE6U6R66U4","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:b2670adc-c3a8-494c-959e-2db31a309ac3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6485","original_object":"UniProtKB:O14842"}
{"id":"eed20157-90f3-41ca-9662-5a3edad87d46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3500","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:9fa8fa9d-ee9c-4ac6-ae05-8b05a3e360dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:335","original_object":"UniProtKB:P11229"}
{"id":"b23ddafe-5675-430d-a17f-f72c6c6f4178","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:b1951430-e327-46f2-9b38-e053de6e4543","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P17948"}
{"id":"240919bb-665d-4ed7-9d89-b098870a2e32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71559428","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:55378ef7-06a7-4e03-bf3f-70ea9d931ba0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6419","original_object":"UniProtKB:P41594"}
{"id":"dd6e7417-178a-4e1d-bffc-c95b59e1f67f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12300","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:c7fda7fc-3636-4c86-b368-55012c23090e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12300","original_object":"UniProtKB:P34913"}
{"id":"b5b1d8bc-9b9b-44dc-a52e-ee9889eb8a51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41872","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:27788b77-5f69-4680-87e3-e4959c7c454b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2313","original_object":"UniProtKB:Q9UGI6"}
{"id":"582935e7-8725-4591-bf2b-5a634744aa8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13768","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:37ac0f83-8b5f-4e8b-a067-3fce6a3ed9c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13768","original_object":"UniProtKB:P30988"}
{"id":"d7e2f637-2ede-41ad-ab0a-cb6dd0045a1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63631","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:7210586c-dbf7-4341-a1f9-9de1fd56762a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6849","original_object":"UniProtKB:P43166"}
{"id":"25f79ca9-f5c0-4cd3-b092-5eb5fc6789eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189668","predicate":"biolink:affects","object":"NCBIGene:5320","sources":[{"id":"urn:uuid:e7c87088-9e9f-45a2-a264-3798830034dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9657","original_object":"UniProtKB:P14555"}
{"id":"b9d38ef7-ddb3-4a3c-aafc-65a1b5bd6808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3791","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:8a413166-2a6c-4dfc-992d-ab9c15c3fef6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3791","original_object":"UniProtKB:P46663"}
{"id":"7fbe8ea2-a6cb-41c3-9cb8-237de28775fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71202307","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:d44203ee-31bf-4769-955d-4eaeaacb1782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7852","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"ce22ff4f-2ae5-4c8c-a112-4b782b97ae25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:6733","sources":[{"id":"urn:uuid:baf9d90c-06e5-4eeb-8719-2e0edc9db7d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:P78362"}
{"id":"197af25c-4091-4856-a579-e4404422723e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138811017","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:37734935-2131-4dad-bbf7-6761accae154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10519","original_object":"UniProtKB:Q9BXA5"}
{"id":"b29d38bd-1387-4a1f-adf8-323ad3c6d327","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993656","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:c4cf990e-a13b-452f-8ce5-72d622a17bb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12571","original_object":"UniProtKB:P21453"}
{"id":"621d8d47-2551-4536-b0ef-6c57c0014541","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16359","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:564d9886-6ace-4669-b059-b6101e9c3c8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:609","original_object":"UniProtKB:Q8TDU6"}
{"id":"6007b03a-e80e-485e-b481-3980bd2073eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:a938a926-a6c4-4b9f-9a30-33737740d4ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P28647"}
{"id":"7557843c-114a-41fc-b32b-91a9270a2f8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2729042","predicate":"biolink:affects","object":"NCBIGene:7347","sources":[{"id":"urn:uuid:975b25bf-67b1-445c-8862-0bdc067d3ec1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8660","original_object":"UniProtKB:P15374"}
{"id":"d65e21f8-5f14-4894-a915-07f1cecbba69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:168396","predicate":"biolink:affects","object":"NCBIGene:3615","sources":[{"id":"urn:uuid:7471d5b5-33b0-4bca-b828-254d4063cdfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6832","original_object":"UniProtKB:P12268"}
{"id":"b181752d-8d30-4746-b249-c0beac2f8655","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754996","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:7d9059a7-4348-4282-80a1-84da97b348ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:562","original_object":"UniProtKB:P26255"}
{"id":"631b9b8d-e338-4d5c-8cea-8f4809c3479b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44584947","predicate":"biolink:affects","object":"NCBIGene:54760","sources":[{"id":"urn:uuid:e05fa418-28f6-4d9f-bbdf-741c343e72cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8668","original_object":"UniProtKB:Q6UW60"}
{"id":"7d7a169d-3978-42a9-b06c-068dd7b3d2c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25099817","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:efdc8d47-23d5-4734-a0bb-5162b118fa59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9112","original_object":"UniProtKB:P59538"}
{"id":"b7c9e60a-331d-4e02-9944-2cfb1084cc53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755039","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:28052fcb-c6d2-429a-bb19-17c54ce04cf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3275","original_object":"UniProtKB:P08482"}
{"id":"8fb485e0-f40a-492e-a600-2f7dbe00e57f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25149519","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:f4dead4a-a49a-471f-8827-0ca210ad6c57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1200","original_object":"UniProtKB:P35367"}
{"id":"b931c36b-9ab5-457f-90d4-bfa30845468c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3815","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:a8148afb-ca18-4e97-93ec-af3f8b6188d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3815","original_object":"UniProtKB:P33535"}
{"id":"c8a4c18b-3904-4219-814d-bb6000fdd655","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76274","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:814ef77e-b0b5-4b15-a959-a9d987756414","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10240","original_object":"UniProtKB:P23219"}
{"id":"53c40a8a-f3d8-4350-88ee-816e86f12bfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311426","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:25690883-f15c-46bf-963c-30d7237c933a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3231","original_object":"UniProtKB:P28222"}
{"id":"fe006882-8d13-4e3b-9bab-a1d1e45196fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"UniProtKB:P30940","sources":[{"id":"urn:uuid:33542c33-5d8f-4f45-be58-555dfe1326ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P30940"}
{"id":"b57d86a1-0e4b-49d4-8288-ec72c33e93e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166194091","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:d1e1e42c-bf82-4d8c-875d-5edd63549815","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13422","original_object":"UniProtKB:Q15391"}
{"id":"a399c99c-960d-4819-9dca-51f11d1b9dd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:29701","sources":[{"id":"urn:uuid:38415d3b-200e-41df-a407-2e30817ca3f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:O88457"}
{"id":"64fbf131-f814-4051-bd3b-1fbd09aab5de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49789112","predicate":"biolink:affects","object":"NCBIGene:7253","sources":[{"id":"urn:uuid:1d4b1f25-906a-48ad-80ed-3ab05731efa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9113","original_object":"UniProtKB:P16473"}
{"id":"6bfd8676-574e-46e0-914c-1bc755ab7e4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:854e0c8d-6d83-47b3-9ccd-fa677485959a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P29275"}
{"id":"2787e75b-df5f-4b75-9840-e2401ef3ecd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91408","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:0aa2e071-547a-4fbb-9245-ed2d99955da3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5716","original_object":"UniProtKB:O60674"}
{"id":"3d862c89-bfec-4b11-b923-71a90074b93d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4164","predicate":"biolink:affects","object":"NCBIGene:353174","sources":[{"id":"urn:uuid:9c4616fa-b7a4-42b2-b0de-bf5a1de87369","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4164","original_object":"UniProtKB:Q401N2"}
{"id":"336ce0d0-07a9-43a7-af9a-f7a828e61948","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18397","predicate":"biolink:affects","object":"NCBIGene:209513","sources":[{"id":"urn:uuid:0e257494-8abc-4a1a-9ef4-99676ce05abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2144","original_object":"UniProtKB:Q5QD15"}
{"id":"c9b43168-564a-4c25-95f7-be55e2375431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16109435","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:768ee20c-be09-4de6-becf-33b75bbd0da6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5607","original_object":"UniProtKB:P0DMS8"}
{"id":"805248a1-4615-4826-880c-886952bfc265","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54585570","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:7512fc60-ff34-4170-8488-2e9d573e83e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5750","original_object":"UniProtKB:Q8TDV5"}
{"id":"ab380b6c-1caa-486f-b07a-4bae56cd09cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U9MOX60GHD","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:3f6e8fcc-10e1-44be-a640-a8d0d7744adb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12603","original_object":"UniProtKB:O43614"}
{"id":"1b337d81-9449-4a9f-962e-4405f583df5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146637574","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:1544ce1d-1594-4aaf-91cb-e9935f81ef6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13958","original_object":"UniProtKB:Q9NRM7"}
{"id":"684a6992-3d0e-469f-95f3-302841713ca9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:6d003c46-7ecf-4de5-b6c8-8911eb2f07a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P07550"}
{"id":"e01c3e81-5616-4eff-a86f-c3ba355853dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:a0ffed17-91fd-41de-b52c-f5582c1df1dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P32304"}
{"id":"84302e1e-43a3-4175-8ea1-98589a5728ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W017G7IF4S","predicate":"biolink:affects","object":"NCBIGene:495","sources":[{"id":"urn:uuid:ae9c8383-9bc6-47d6-85ee-5c3e3b5c0529","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12008","original_object":"UniProtKB:P20648"}
{"id":"0d07c0c8-8e69-40bb-a93a-ec7712d8c106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46900258","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:7f2f01de-be01-4518-aac4-14f33e91f5a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8550","original_object":"UniProtKB:P27487"}
{"id":"af008543-eef9-46fb-8cf1-f5057546b184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77097","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:d4802d66-73b1-43a2-9318-74f661c840f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2442","original_object":"UniProtKB:Q9Y210"}
{"id":"cce55b2c-8c87-40e4-af87-e979abd705fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136205832","predicate":"biolink:affects","object":"NCBIGene:54583","sources":[{"id":"urn:uuid:1fa678bf-ac65-4c83-a28c-9725c1be1276","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8796","original_object":"UniProtKB:Q9GZT9"}
{"id":"cb9311b0-df98-4695-ab9e-5f28ab1c5564","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34968","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:466d5720-2ef9-4975-9a5d-446938495bf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4197","original_object":"UniProtKB:P47869"}
{"id":"75f90a57-b6c6-4f43-9881-0c34eca7d2c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CCP2U6LWTP","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:f6112f40-189b-430c-832c-1d0edf2ea60c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9135","original_object":"UniProtKB:P47871"}
{"id":"1eac1ade-4d96-4afe-9c56-85c02b2298e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:34ZKU73FU3","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:670fac7a-cde6-4ad1-9ae6-cf4e31f22dfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9061","original_object":"UniProtKB:P06401"}
{"id":"c4e07e47-5250-4904-b17a-46bf3d5a1e18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCL936W835","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:8a94e4e0-becf-4b35-9cda-2d85c0f88c47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7743","original_object":"UniProtKB:P42336"}
{"id":"e0351a4f-0ecf-4755-a37c-bfb83d1df17a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230483","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:72b25b3b-3cfe-45b8-a973-18d659fa9a91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8955","original_object":"UniProtKB:Q86X55"}
{"id":"639ec0b4-f991-4518-85cd-383feebeadd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9949202","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:e82f9b8e-93de-43bf-977d-813623cbb6f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1387","original_object":"UniProtKB:P23385"}
{"id":"971075cb-badb-491d-91f5-d406e3cd59fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:215747","predicate":"biolink:affects","object":"NCBIGene:196","sources":[{"id":"urn:uuid:3d986d49-7913-402e-a275-16da6c125d86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9686","original_object":"UniProtKB:P35869"}
{"id":"84343e09-437c-47df-8355-76ee1d9ccfdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221648","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:69b46c2d-9ab7-4ff1-b1c6-618fb46f25b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9465","original_object":"UniProtKB:O43613"}
{"id":"9a6370f8-01ce-49cf-8f34-debffe46a742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182080","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:02949f86-87a2-4a07-9674-d5fdf2fc34de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1606","original_object":"UniProtKB:P41143"}
{"id":"2e33f888-f64d-4764-81a0-c38cc1ac4b2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5332695","predicate":"biolink:affects","object":"NCBIGene:23410","sources":[{"id":"urn:uuid:4ebc0a7d-8487-4b50-9a7b-5fa13ec7f49b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13730","original_object":"UniProtKB:Q9NTG7"}
{"id":"a8ce2b3b-d3e3-4b84-ba06-26e9ccddcb2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44472568","predicate":"biolink:affects","object":"NCBIGene:140492","sources":[{"id":"urn:uuid:30fe23ca-bb0f-46f8-b707-21d65d723184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9316","original_object":"UniProtKB:P58390"}
{"id":"bc7cc340-10ec-4c75-9eb7-250058371d18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996536","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:3899ad3f-3e7b-48d6-bb9b-8098426c0ecc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10649","original_object":"UniProtKB:O00329"}
{"id":"3dea5174-2086-4166-bc06-5d5b3365415e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30769","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:e946b2ab-744e-4167-a3d1-613b5bed8a15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2478","original_object":"UniProtKB:Q9EPK8"}
{"id":"93a74edc-f290-4d31-af72-715495fd0537","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OEP8JJ3OZR","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:0996d551-14e0-4fc4-b39a-12164dcfc615","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9425","original_object":"UniProtKB:P42338"}
{"id":"6a5745bf-d495-458d-bd91-f866c09b354a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155332312","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:8f7e7814-5c02-4d48-8064-a36839c017c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13767","original_object":"UniProtKB:P01116"}
{"id":"257534c2-7940-47e7-90ec-8947981d8ba4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167204","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:46de5a43-ff60-4957-b288-8b602fb2bc3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:242","original_object":"UniProtKB:Q13639"}
{"id":"068dead1-b65b-4dc8-b95c-2e86dc4f7fbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5017","predicate":"biolink:affects","object":"NCBIGene:9990","sources":[{"id":"urn:uuid:4f36c553-a256-400a-b421-94684a1e42ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4589","original_object":"UniProtKB:Q9UHW9"}
{"id":"e245ee43-ff31-4063-b166-f00523628db8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:970375","predicate":"biolink:affects","object":"NCBIGene:6768","sources":[{"id":"urn:uuid:83a37edb-476f-46f1-9b47-66d35825778a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8488","original_object":"UniProtKB:Q9Y5Y6"}
{"id":"17ddfdbf-dd30-40e0-95d1-485337debe55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2166","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:eefb9ed4-e84c-423f-beb3-d81e1e580d64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2166","original_object":"UniProtKB:Q9UKP6"}
{"id":"23cf59fb-9702-4227-a4c2-48d4c84d6075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:57118","sources":[{"id":"urn:uuid:3aeb4697-2a8b-4207-a169-7a858230d744","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q8IU85"}
{"id":"760fc394-c7db-4d5c-9452-8eea0eb61aa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53325462","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:becea8e5-13c9-4641-b5f3-629202ae6bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3272","original_object":"UniProtKB:P11229"}
{"id":"a9c09e81-f2f9-446c-9f31-f4820d64341c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5441","predicate":"biolink:affects","object":"NCBIGene:3767","sources":[{"id":"urn:uuid:de60d568-994b-408f-9920-4861903dc4ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2414","original_object":"UniProtKB:Q14654"}
{"id":"92577bae-f3eb-4614-866b-f63cfe18575e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277838","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:d086156c-66ae-4d6b-acd1-123984fa29da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7773","original_object":"UniProtKB:P49286"}
{"id":"140af5a9-3f4c-4372-9ffe-b7610cc57a4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101248666","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:2faa169c-3723-4165-8e51-f384077f33ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10228","original_object":"UniProtKB:P21730"}
{"id":"201a7a5b-52f9-4486-b3cd-befb2210cb16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VGZ6BSQ5DR","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:5ea46ade-2816-48f6-ad89-ab05511ab73f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11206","original_object":"UniProtKB:O14649"}
{"id":"c2c5ae65-b336-4623-bdbd-84eae6721d87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4942","predicate":"biolink:affects","object":"NCBIGene:1438","sources":[{"id":"urn:uuid:105d5277-4691-46a6-83b8-8cf92c18b7a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4942","original_object":"UniProtKB:P15509"}
{"id":"3c886059-1b25-412f-9322-687e13feb5b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124037381","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:88d0aebf-0070-4158-ae70-4d2f460e301e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9391","original_object":"UniProtKB:P06239"}
{"id":"bbca4d4c-68cd-46cb-b4df-0acda761fa79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91832","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:71a6d3f0-98a8-462e-8b94-5f91a4d8d15d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3285","original_object":"UniProtKB:P28647"}
{"id":"57866a97-3523-4b8d-bc63-98f9f88bbb0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9824142","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:6a277dc2-b20e-4b28-8347-dae85c82152c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6162","original_object":"UniProtKB:Q9NPC1"}
{"id":"14c893fa-5e44-4eca-9baa-546a2b3e11a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130169","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:1b575d70-4d1a-44bc-aa49-409dc923f89f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:331","original_object":"UniProtKB:P08482"}
{"id":"c7e83dd4-e027-43fd-9890-d80dd242675c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114904","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:8f6f1a19-2897-4ec4-b2bd-130c677ba78e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2196","original_object":"UniProtKB:P30559"}
{"id":"6ad76926-f0e6-43f6-aaad-060b03d7e183","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123884","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:9bf6b899-fc20-4bf0-aa83-fcfc9297ae2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:641","original_object":"UniProtKB:P46663"}
{"id":"bb07d716-e592-42b6-8aae-9d6dee62f757","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11540659","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:1a36aa3f-3db5-4cda-9965-4a2902c2fea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8193","original_object":"UniProtKB:P06239"}
{"id":"7869159c-6bd8-493f-b773-bdc3eb397f12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:4cd85ffd-9949-4121-85e8-597b735fb5f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P14842"}
{"id":"3f622c16-a1de-4574-962b-e40ea8220780","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5995","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:76f61d8b-1a1f-42c5-9827-189df34760dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12549","original_object":"UniProtKB:Q8NET8"}
{"id":"8c8a3a16-ea16-4076-9b9f-86d11fc6cbbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0WAX4UT396","predicate":"biolink:affects","object":"NCBIGene:5787","sources":[{"id":"urn:uuid:dedb1234-777f-468b-9710-ff8c327db093","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11336","original_object":"UniProtKB:P23467"}
{"id":"ba7ef1ff-4d2a-4fc8-8129-2454439b31d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92263","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:0be424bb-7c38-4860-b04b-72abf4cceeb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4179","original_object":"UniProtKB:P34903"}
{"id":"9be25c92-8278-44e1-8afc-a4ce201ae6da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53252525","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:147318eb-feda-4286-bbb7-4b224a8362d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6395","original_object":"UniProtKB:P31424"}
{"id":"de8386f9-aeb1-4db5-a992-cf7d7ebffe27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G8RGG88B68","predicate":"biolink:affects","object":"NCBIGene:3454","sources":[{"id":"urn:uuid:c3364864-28b3-476b-a586-9941673333c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7462","original_object":"UniProtKB:P17181"}
{"id":"78314533-e946-4b79-88c4-47a7bd051148","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:b8a5e0cc-0c89-41e9-a227-12a1f97a964a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P28335"}
{"id":"183f6336-76eb-4586-a5cf-bc77ab5b722d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79978","predicate":"biolink:affects","object":"NCBIGene:24182","sources":[{"id":"urn:uuid:50afb647-178d-4f24-a4d3-157ccc5f328b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:596","original_object":"UniProtKB:P35351"}
{"id":"10eff681-4d19-4890-a3fd-1be362d49186","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90528","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:c5095c7f-e7c5-4e0b-9229-e0815e6dd0f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5719","original_object":"UniProtKB:Q16539"}
{"id":"963ea866-ba73-49bb-be8c-1fca7b41a1db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7928","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:108f332f-9017-4c3d-b9e6-cf1a7cd6e944","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7928","original_object":"UniProtKB:Q9HB89"}
{"id":"952c9150-b6ca-4b2f-a48f-c2415c3e7961","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231425","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:de572a83-f88a-466b-9615-ce9a2bf2d709","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2226","original_object":"UniProtKB:P30560"}
{"id":"a952b2e8-cd77-4095-818c-2249e47bd789","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9904703","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:8db02d1a-3633-47ec-aae6-72368f690dcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1390","original_object":"UniProtKB:P23385"}
{"id":"60ecfc00-b35d-4853-a4ca-67cd3eabfe28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S3OPE9IA3Q","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:6d7a00d5-b48f-411c-9652-65a83d8f18df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9788","original_object":"UniProtKB:P21802"}
{"id":"8ef2067c-6365-4f0e-bb19-9bf04ae64414","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169171740","predicate":"biolink:affects","object":"NCBIGene:5641","sources":[{"id":"urn:uuid:3ff3bc58-a113-4d18-844d-6715eca5709e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13109","original_object":"UniProtKB:Q99538"}
{"id":"0d18bd5d-5444-423e-a328-e7638721cf62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228346","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:8013fc6a-3cca-4bb5-b352-035568934b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10454","original_object":"UniProtKB:Q96RJ0"}
{"id":"9fa05e8a-327c-435b-94e4-5637626b5151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9842609","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:dd7ce371-fa6b-49f1-b7ac-debfa095ecad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4310","original_object":"UniProtKB:Q8NER1"}
{"id":"82cd312c-aa83-43ac-bfdb-b7e58891c834","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2232","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:6d151222-12b2-416f-8acd-d53e771e3aa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2232","original_object":"UniProtKB:P30518"}
{"id":"c9094d66-1b56-4974-80bf-9194a5684353","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:efa7523f-5c69-4f75-ab83-96c4de0333f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P30875"}
{"id":"70af3c89-248f-47be-8b0a-9fdd65e9474c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5461879","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:f93d255a-abae-438b-87f7-5702fcc88eb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5603","original_object":"UniProtKB:P25099"}
{"id":"3b15d196-f8af-4342-a049-5afef571b049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75644","predicate":"biolink:affects","object":"NCBIGene:54429","sources":[{"id":"urn:uuid:b0efff2a-5d2a-4bcf-a933-ff4bc7d15fbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12426","original_object":"UniProtKB:Q9NYW4"}
{"id":"5bd12b54-e766-4a82-9342-a86c4487ae37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1301094","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:a1b98943-4529-4ef6-b15a-d22f10cd0778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7662","original_object":"UniProtKB:Q12809"}
{"id":"5392f179-9d68-496f-a0b2-609d9c1b41df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134163708","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:28b8ce2e-b909-4605-82cd-a2b3a680d165","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10233","original_object":"UniProtKB:P42336"}
{"id":"a6ed1e7f-daa6-4dab-85ae-2eddef5fe6a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6081","predicate":"biolink:affects","object":"NCBIGene:17171","sources":[{"id":"urn:uuid:9bbd9684-b926-4770-a451-82fa4c81fbe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6081","original_object":"UniProtKB:P30554"}
{"id":"8acb5006-f5d3-4574-b6f2-de8d7d9074bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93344","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:70c69ab9-c8ee-44d4-9377-01ee403f047d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3461","original_object":"UniProtKB:Q92731"}
{"id":"a8166f90-a645-488e-8544-43f236ae3125","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:7e875922-b2d3-4297-8688-10c4b29a5745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q16322"}
{"id":"63707358-4d66-42e4-bb82-798645653c00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57180216","predicate":"biolink:affects","object":"NCBIGene:7174","sources":[{"id":"urn:uuid:b91fcacc-2a95-4be5-8cc6-90f2461c76a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8581","original_object":"UniProtKB:P29144"}
{"id":"9b2aad92-2ddf-4aa7-bc81-209860b03a6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144093","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:ba63cf5c-0d7b-4b0a-8ebb-48fd7ba99c59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2863","original_object":"UniProtKB:P10275"}
{"id":"f7914f96-4764-4bf7-ab94-67e5ea590e57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9342","predicate":"biolink:affects","object":"NCBIGene:116085","sources":[{"id":"urn:uuid:a67fe719-4b24-4740-9461-e4879bbfe783","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5826","original_object":"UniProtKB:Q96S37"}
{"id":"de265d39-d0d6-418c-b2d9-ecda753606fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5558","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:1843b10c-3cfd-47e8-882f-080720f83c29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:522","original_object":"UniProtKB:P08913"}
{"id":"ea537352-bdbb-4890-b85c-222e7c9df27e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:65UT4V5Z34","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:996c6e8d-067f-4424-8639-f5f39ae12ebe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:348","original_object":"UniProtKB:P08172"}
{"id":"f964db24-c817-499e-a679-3d430962ac2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90687","predicate":"biolink:affects","object":"NCBIGene:3320","sources":[{"id":"urn:uuid:34a59eaf-d527-4047-86c9-890460eab461","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9258","original_object":"UniProtKB:P07900"}
{"id":"ddbd1ba2-408a-447f-ade9-673fc9b4de04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23399992","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:921cd0fe-0862-431e-8ae7-c79845b15f3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4096","original_object":"UniProtKB:A8MPY1"}
{"id":"9c2f3638-ec8b-4320-9b91-226a522ed479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133818","predicate":"biolink:affects","object":"NCBIGene:23387","sources":[{"id":"urn:uuid:aa5f7436-9db5-4df6-9ec6-d23ecfb861df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8049","original_object":"UniProtKB:Q9Y2K2"}
{"id":"c6b6df1c-8c61-4220-8df2-26da19075609","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91408","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:6eb8bc04-62ba-4434-b9a4-cf28bda13ec3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5716","original_object":"UniProtKB:P29597"}
{"id":"6a511a9d-0e97-4c23-a765-a0316d2e8819","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22991950","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:aed8dc36-1dea-40bd-ad60-4ed9c90181aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:326","original_object":"UniProtKB:P08172"}
{"id":"64297fbd-f541-40bd-92e6-3bba693416f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9654","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:d94e7307-6d49-4e3a-93f2-a11a44d36311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:213","original_object":"UniProtKB:P08909"}
{"id":"2c4e53f1-2f87-4f9d-9bf8-6324fad9a84c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11909","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:860bf0d0-f055-4535-b762-f93eb64848b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11909","original_object":"UniProtKB:Q9NSD7"}
{"id":"79b1118f-9c48-4d74-befb-36d4ee5ca202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:c5551eec-5344-4b1a-b179-0b5b80dd11cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:Q13464"}
{"id":"fb0749cd-772b-4b21-933e-6d9e6cc1fcbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44123300","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:4b158331-c892-4d3f-8225-f5de04de4f97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1714","original_object":"UniProtKB:P47900"}
{"id":"6d5d28f1-2ce5-482f-b5af-7ad5d0ee8a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3087","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:68c90236-2c3a-43fe-8219-72f850c90190","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3945","original_object":"UniProtKB:Q8TDU6"}
{"id":"38dfe749-9e6c-46d4-b5ff-91f2849fc0c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1320","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:5d13a623-09fc-4e46-b0f4-f4957685778e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1320","original_object":"UniProtKB:P32245"}
{"id":"ce5d157f-8643-46ca-ac05-c3cbe73ffc83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:31c82f12-5337-4da2-8bf6-3310f0ff9e3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P28566"}
{"id":"beb0b640-65ec-42be-8211-6e76197d130b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155309155","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:fa208235-8895-4499-8287-3115427f2c33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12370","original_object":"UniProtKB:P21802"}
{"id":"ea3e8cc4-b597-49be-8b5c-bfefc95feb7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5115445","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:72c1735f-306d-4edc-b9bd-4e31bdcaa9bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:159","original_object":"UniProtKB:P14842"}
{"id":"18e939bd-e0e8-4f9f-a5ab-bdf190db0f74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L1V1K2M4V","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:3dbf5982-6cc0-4c9e-9b79-1f1889be31bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4461","original_object":"UniProtKB:O43614"}
{"id":"d264eb07-4480-458c-bf5c-8b3dbc3de717","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864283","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:a49c4a6b-067b-4b2e-84b3-5cdd21617bbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8209","original_object":"UniProtKB:Q13464"}
{"id":"a261d002-1764-458d-8650-873f0074d82e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76072","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:2d4c4413-a4bb-4e09-966b-bdcda28c5ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2450","original_object":"UniProtKB:O94759"}
{"id":"3d60d2ea-c722-4bfb-8066-767ba7c6ac54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1479","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:34322d53-2a67-43ba-ab95-55e577c22e44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1479","original_object":"UniProtKB:Q9Y5X5"}
{"id":"b72ec31f-8c7a-4156-8b06-0e3177547b68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:204851","sources":[{"id":"urn:uuid:d2d3d763-1c66-4584-89ea-e14213f472ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q86Z02"}
{"id":"53a83abc-6097-43fe-b11a-88199122bd8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232982","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:dc9ee4b7-c1e8-4094-88de-e905d3ae3611","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:188","original_object":"UniProtKB:P41595"}
{"id":"baad187a-2273-4709-9f46-6da598ecbf43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZE94SP78UG","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:b20aebfc-42fe-401b-98cb-e55d8d514068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13496","original_object":"UniProtKB:P36888"}
{"id":"5a93c146-cb75-4125-a52d-e145c817dbca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:62A9CG81VN","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:965f735b-e9bd-4e6a-8562-60ff50821db6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7728","original_object":"UniProtKB:P05164"}
{"id":"852b31dd-9e1f-4cde-a9e4-0d074b155289","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755066","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:19661f5e-dfa4-4895-9c64-280e87017bc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3982","original_object":"UniProtKB:P32297"}
{"id":"5368cea7-66d8-4aba-9e6e-da66ebc4f467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:5e20a8a7-b888-4643-97ef-f76328812728","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:Q15303"}
{"id":"f440a6ec-6808-419c-a83a-3507b158ec2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6427057","predicate":"biolink:affects","object":"NCBIGene:29659","sources":[{"id":"urn:uuid:9b88b70b-3372-4f51-86f4-b0b569e8b590","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2373","original_object":"UniProtKB:P51577"}
{"id":"14169b3e-1814-4931-8503-cdf36bc5d989","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11772954","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:d91e4beb-51fc-498c-99af-0f086ae8b37b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6349","original_object":"UniProtKB:P23385"}
{"id":"e3b13819-fead-4514-9e5a-407087f96318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9453","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:5407c9c1-feb2-4f0c-95ed-7de5c12db1f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2608","original_object":"UniProtKB:P35367"}
{"id":"8600521c-8a93-474e-8bfb-b8d17b2feb5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111179","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:c62db9a2-d4c7-480f-a73e-b037c4f7d9a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1068","original_object":"UniProtKB:Q9Z0U4"}
{"id":"5ce7371d-de71-4c9f-95af-86b47ec95476","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2455","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:2a587f47-7fd4-4985-9c91-31a71735baa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2438","original_object":"UniProtKB:Q13507"}
{"id":"f5ae3b76-dfc3-4291-aa39-33889d4abce1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131967","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:6f94e51e-f635-4613-911b-e14820a5b070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1046","original_object":"UniProtKB:P25089"}
{"id":"13d638fa-2a6f-41e5-b896-6b0d37cc402c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118893637","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:ace5cad4-1f5e-44d4-ba4e-3b9734907171","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13218","original_object":"UniProtKB:P11362"}
{"id":"8e40a402-46bb-4c36-950d-f6b07dfc4673","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61390","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:d1ed81b2-2503-412f-8c31-f572f5aefe9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5667","original_object":"UniProtKB:P04626"}
{"id":"f03f13ed-fbf7-4db7-8a93-c848071a91f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:b700bc41-3ce2-4414-9413-d126c3eae2b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:P23979"}
{"id":"5ac8e512-72bb-496c-beb0-c48b61ce6ae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311023","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:4f9e89ba-e209-45c8-8ee8-6dad1ebde77b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1485","original_object":"UniProtKB:Q9Y5X5"}
{"id":"4d88e08a-1572-4fde-b35f-465f9273bb74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:a69b5c92-5dc6-46ff-9298-29790375e34a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P30530"}
{"id":"f12f9696-c0bd-466c-aca4-85d6095102d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9588","predicate":"biolink:affects","object":"NCBIGene:1555","sources":[{"id":"urn:uuid:86f9142b-dcd7-4004-9629-347db9812cb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7307","original_object":"UniProtKB:P20813"}
{"id":"82f1c58b-fc7e-412d-8e07-764f3fe90e6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156304705","predicate":"biolink:affects","object":"NCBIGene:227289","sources":[{"id":"urn:uuid:dcb1252f-9034-4881-b26d-7a0adafe6d1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11697","original_object":"UniProtKB:Q80SS6"}
{"id":"566aecfb-302d-4ead-9560-728c0a764c91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45951","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:c1f68c6e-ad2e-4151-8526-11fa975ea640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:214","original_object":"UniProtKB:P14416"}
{"id":"819c4a91-87ad-430e-816b-7fff6f7b658d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:951de631-6d5b-47a5-827f-0a1a7021d002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P14416"}
{"id":"031c956c-5b67-47ec-9048-508bf324146c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2542","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:36c05c8a-70d7-4abd-b9ec-94a8ea971aa3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2542","original_object":"UniProtKB:Q07652"}
{"id":"e98a838c-7640-48c3-929f-a2e459689ded","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y6BX7BL23K","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:feca4608-7b32-41b3-900f-5c42b375fbe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9767","original_object":"UniProtKB:P22607"}
{"id":"4740fbe2-7f37-4b11-879c-0234e6a22a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5860","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:6b7e466c-a521-4330-a1e0-a50878f6415c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5860","original_object":"UniProtKB:P43114"}
{"id":"7d9e052a-0bac-4111-90d4-cceec9a49cd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28197","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:196b1415-9ef8-40e1-84b3-5170a0637cc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2828","original_object":"UniProtKB:P62508"}
{"id":"a44c7f66-5adf-4898-a433-01c3b7f60031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92537","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:77f2a275-8a20-4bdb-986d-4f12f324e9d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:28","original_object":"UniProtKB:P08908"}
{"id":"5453284b-b84d-4d6c-917e-4ca2b3850541","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63630","predicate":"biolink:affects","object":"NCBIGene:1312","sources":[{"id":"urn:uuid:1f62f274-531a-4728-8e93-0a4153042be6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6646","original_object":"UniProtKB:P21964"}
{"id":"0d1ff075-613e-4da6-848f-abc7d2b8920e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14851316","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:f4decad7-70f9-41bc-a17b-6649ee71a444","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2984","original_object":"UniProtKB:P51639"}
{"id":"bebd3e4b-c698-472b-855f-c09ba7cb531c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132316","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:59e7daca-ed2e-4c28-987f-d0fcf6ba398d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1643","original_object":"UniProtKB:P33534"}
{"id":"d037666c-925e-40e8-961e-b02aad43f17b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91348","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:ef4b8d33-5ca1-408a-9723-5945efc58b70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5706","original_object":"UniProtKB:P07949"}
{"id":"f20392f3-0e8a-46a8-bda7-04ca79d23a4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:107691","predicate":"biolink:affects","object":"NCBIGene:24613","sources":[{"id":"urn:uuid:20abc5df-1475-40d4-82fd-8cf01512ba26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1636","original_object":"UniProtKB:P33533"}
{"id":"0f028ede-e32c-469f-b251-7f11389597e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3AK2RKG763","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:9621c3f3-a79b-45cf-8931-99a723692482","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:497","original_object":"UniProtKB:P35368"}
{"id":"ffa32a3c-f841-4f38-a48f-e15af85da735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:5338","sources":[{"id":"urn:uuid:e49a3de9-e046-4f07-9cff-b8586545166e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:O14939"}
{"id":"e3fe0158-6cc6-4f75-8afd-132b2ed1cd68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2058","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:aa98db3c-1c8d-43b3-b69a-ba98e8959b45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2058","original_object":"UniProtKB:P30874"}
{"id":"9455100e-f043-486c-aa65-dca47883e4e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72199293","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:e44e69a7-e954-4fee-9ff3-abec14cc2e05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7013","original_object":"UniProtKB:Q15910"}
{"id":"3edc8d1c-114e-4cf1-8035-4e11a18f8806","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118224238","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:cadba614-184b-44fe-bf87-e46c0efcf484","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10152","original_object":"UniProtKB:Q9NWZ3"}
{"id":"89050adc-72d8-4bc0-86e0-3f5235b671a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4702","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:3c429c61-2644-4da1-93c3-9bb5fb4afe2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6810","original_object":"UniProtKB:P43166"}
{"id":"51647c47-991c-406f-a9a5-84e9b67e1082","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8077","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:07880e2f-0d80-4615-a705-7f1e8db902b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7268","original_object":"UniProtKB:P18089"}
{"id":"93e20e04-27e2-4ce9-ada9-36c13375baf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803245","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:edafaaee-1583-4da5-81c5-1f6e25c20c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:339","original_object":"UniProtKB:P11229"}
{"id":"16c491eb-191b-43c9-86a0-63d9dbd01dc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9RIE5HW38P","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:279aa327-d49d-47d2-be21-a6fde6b78b96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7642","original_object":"UniProtKB:P00533"}
{"id":"763c94dd-b944-44ac-97cf-a597799029af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:14427","sources":[{"id":"urn:uuid:042cbbf9-5893-46a4-b0f4-c1ec30bee046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:P56479"}
{"id":"c3776e9a-96c1-46b4-ad01-443c3db648fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11983295","predicate":"biolink:affects","object":"NCBIGene:3654","sources":[{"id":"urn:uuid:9a3fb439-cfff-49c8-a7fd-3b0dae5c1f47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5990","original_object":"UniProtKB:P51617"}
{"id":"cc9d52d6-c095-4dfa-98a5-57c87932de21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5720","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:0df4ceb1-440b-4823-9468-f3938cbb13ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:324","original_object":"UniProtKB:P08172"}
{"id":"1191d2a3-4a13-437d-992f-16d101a4f97f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:70523a8e-28ab-480d-8267-a13a6bb29316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P34903"}
{"id":"b14aaeaa-b84b-4e1c-a04d-44dcf8ab0037","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:84I5UEP321","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:de7addba-6703-4fd3-af26-2c77e71375e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10193","original_object":"UniProtKB:P29274"}
{"id":"7dcb809b-617b-49f8-b096-7b4950bd6f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3558","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:7af8d853-718c-4926-8fb0-6931a01d5789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2950","original_object":"UniProtKB:P04035"}
{"id":"2ed9da35-7882-4fa1-9562-4c1db663cd78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34732","predicate":"biolink:affects","object":"NCBIGene:117018","sources":[{"id":"urn:uuid:f1c0a864-b34f-476e-b9e5-b95d40466d90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2605","original_object":"UniProtKB:O08962"}
{"id":"90f258fd-cd51-4600-8522-4a965f477981","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94843","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:22052903-158f-467e-96b4-180ba8e8ffbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:807","original_object":"UniProtKB:P51681"}
{"id":"cc3b5231-9a27-4084-9c35-1389bb4b6242","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46213949","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:be61533a-12f5-4a36-9372-5bbc8f6ed3d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6988","original_object":"UniProtKB:Q92633"}
{"id":"527dc759-01d8-4a2a-83a3-37efa6b32782","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43876","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:d6fa6e82-0adb-48a9-bd2c-7e3b6c875c02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1373","original_object":"UniProtKB:Q14832"}
{"id":"aa05c3b3-f648-4a93-a778-c67e9ee3b4a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:7478ec4a-cdc4-4d8b-bec0-b5ee575c63e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P41587"}
{"id":"aa883dd9-b0c7-40f6-b1e5-4b93d46bf671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121918","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:07660a57-c454-43cb-9cd3-1c1e9fab648f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4239","original_object":"UniProtKB:Q14957"}
{"id":"bef25671-c313-440e-a1b1-ce32d15a2a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817380","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:7a11ab00-fdbd-499a-93b5-3adc44e4811f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:648","original_object":"UniProtKB:P46663"}
{"id":"c020e583-8b72-4ba9-811b-d62887415a4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311190","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:6c52eace-ed6c-47e2-b1a9-eb2052e4b1df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:957","original_object":"UniProtKB:P19020"}
{"id":"dec5de87-db56-447e-a3f5-b6ca10ef28d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:147302","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:fa4e17c8-6a45-47ab-a68a-cb9f42302287","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3944","original_object":"UniProtKB:P50052"}
{"id":"de6e19b5-46d9-4639-a102-794c082a5f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DRZ23E4F7","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:76347835-369b-458d-8303-6a79fd1a4d70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5619","original_object":"UniProtKB:P29274"}
{"id":"1e8a8379-3e00-4897-b9c6-5676a9f3eb48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93069","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:af03dbd7-9f7e-41ec-97ea-765ad59613d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3512","original_object":"UniProtKB:P34998"}
{"id":"a5267192-43ee-447d-896d-4df94ee932c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47499","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:ec8db65f-3355-4f36-98c0-dddea5ea8101","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:357","original_object":"UniProtKB:P08172"}
{"id":"d33367c5-9087-4406-8350-41763288da52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2044","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:6b305f05-0cee-4523-b853-8e77ed65ffb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2044","original_object":"UniProtKB:P30875"}
{"id":"804991fc-752c-4613-b1a9-7ac3a037c234","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:fac17211-c9b4-4274-a698-52b25af146d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P41595"}
{"id":"85d14642-e667-4107-bf07-410f9a65fed6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86H6B395PI","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:d9f1877c-ae0b-4759-94b0-85aa3e878c76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1218","original_object":"UniProtKB:P25021"}
{"id":"d1d48503-c0fd-4370-9da2-a2d7e70356ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155180028","predicate":"biolink:affects","object":"NCBIGene:6558","sources":[{"id":"urn:uuid:976ea25c-77ad-4608-b996-661eae2bdfbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13840","original_object":"UniProtKB:P55011"}
{"id":"7fcbc1aa-4b9f-4a3c-a4b8-6b1c4a8f9162","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:1183","sources":[{"id":"urn:uuid:d7415775-19c6-498e-8266-50416fa308a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:P51793"}
{"id":"1d482b56-45bd-4852-862d-fac56b80b998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48574","predicate":"biolink:affects","object":"UniProtKB:Q50KZ9","sources":[{"id":"urn:uuid:7eafd6e6-4257-4e6b-9e6e-1a8fd50d6aca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7270","original_object":"UniProtKB:Q50KZ9"}
{"id":"c8d5cc37-b05c-458f-b283-7df3c952504c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10542","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:acacce55-a738-4ba4-ba75-b598a7306e3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10542","original_object":"UniProtKB:Q9Y2T6"}
{"id":"59635913-0633-4f1f-a6d8-3d898e6b328c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92593","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:71288b02-cf64-4d28-ae62-70730bd243f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4346","original_object":"UniProtKB:P34903"}
{"id":"cbcac9f3-93fe-497a-ae09-ee2e2073d7b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6832","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:e63eda84-645c-4d58-bced-c2923d77c7a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6829","original_object":"UniProtKB:P00915"}
{"id":"edaf0287-ae06-4c6b-8cbd-1cad7f28d378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93363","predicate":"biolink:affects","object":"NCBIGene:294122","sources":[{"id":"urn:uuid:8f6068db-da5e-4f6b-a48a-61efa0db5154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5509","original_object":"UniProtKB:Q923Y7"}
{"id":"dba32c67-f51d-4622-8fec-9d1bdafa1a7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:d34c2e2a-dc96-4faf-8f55-e34a1b14f36f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P43115"}
{"id":"7c726732-81d3-4d01-9915-63ba14533786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230958","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:0adf62e3-ee8f-429d-bb2d-60c7484fcc91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6894","original_object":"UniProtKB:P50052"}
{"id":"d618fa03-b484-4747-9762-aa02c30c18cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93452","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:46d14711-b247-499a-b166-89fa1799c892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4296","original_object":"UniProtKB:P47869"}
{"id":"88a3bd9c-9073-4eec-ba49-95355a4567cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141346","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:722f6575-d0f9-4792-b63d-6f956b8f0700","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9512","original_object":"UniProtKB:P13945"}
{"id":"afb941d5-67c5-4770-b939-849f4d740ad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18243","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:bc553d5f-1b0b-4da2-b23f-03cafac5c87f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:940","original_object":"UniProtKB:P30729"}
{"id":"62404d0f-df67-41fc-8f31-b15beaee2d8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40139","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:a44db34a-2d97-477e-9d07-d2ab1512f370","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1392","original_object":"UniProtKB:Q14416"}
{"id":"67f68107-4f25-491e-b6b6-1d40b646f984","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755152","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:aa45e056-55f5-4ace-80a7-59c19c427366","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5744","original_object":"UniProtKB:Q8TDV5"}
{"id":"f8521956-0343-4e79-9237-075fd280a7dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925850","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:7fdf8120-5a57-4047-87fd-4a1794ddaa51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11565","original_object":"UniProtKB:P52333"}
{"id":"38f32925-51b6-4a4d-8d84-156c9aa10003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92950","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:84a97ef9-7ff2-4289-8b47-3f619f3c617e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:515","original_object":"UniProtKB:P25100"}
{"id":"ef1fd1dd-e381-4b25-8ec9-11e8ef112887","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16914","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:4112146a-1a0c-4ecb-9b07-1507771ce299","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4306","original_object":"UniProtKB:Q9UHC3"}
{"id":"17eb1b29-2de9-4b14-b565-512ed96f9e0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91385","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:6e5569cc-61f1-46c4-aec4-09c72a765bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8043","original_object":"UniProtKB:O96017"}
{"id":"d413da47-c66d-4d56-ac9b-d22f3908c2e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3824","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:7b32637f-5d2e-41d4-84eb-24fa13f241f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3824","original_object":"UniProtKB:P41146"}
{"id":"e9740979-b431-4d68-9129-785fb25457a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1987175","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:012b5f12-0edc-44c7-af53-e70ed5105f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9283","original_object":"UniProtKB:P43119"}
{"id":"ed135ba9-b387-46e4-a294-bcc03d69e213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5049","predicate":"biolink:affects","object":"NCBIGene:19116","sources":[{"id":"urn:uuid:db501de7-2634-4996-9477-efbaffc61c8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5049","original_object":"UniProtKB:Q08501"}
{"id":"88f8b356-613a-4cf9-84fe-96286873a9b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:06H865SCMW","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:9a010af5-5f47-47c5-805d-3e6debd0bdd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10162","original_object":"UniProtKB:P42336"}
{"id":"e1d6e05f-05a6-4105-9972-1523e847edc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10082","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:4b174f3b-d1db-4c2e-9d95-ecd0f2ac095f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:517","original_object":"UniProtKB:P08913"}
{"id":"8b78aacf-22fe-45d6-bac9-eff130dd708e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D01E4B1U35","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:760c17b6-3957-451c-b20f-c1e4b9144c30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9862","original_object":"UniProtKB:P52333"}
{"id":"57335925-60d5-4163-b275-a608286f1af7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154578239","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:9d01e1f5-041c-4d7a-8f54-3873cabe08f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11213","original_object":"UniProtKB:Q9NQS5"}
{"id":"641a00b6-2144-4b9d-a230-0fd232091033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:371cc1b8-b808-4d29-8d02-6d6af3600e16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P30939"}
{"id":"7dd10034-599f-47a3-bac9-b2c2726957ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9802941","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:0d5d3db2-7924-4e6e-9b72-230d3b19caeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:473","original_object":"UniProtKB:P0DMS8"}
{"id":"03c96ec5-655a-4420-a8a4-c82abdcaff65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3A58010674","predicate":"biolink:affects","object":"NCBIGene:1441","sources":[{"id":"urn:uuid:79785309-b9f8-4761-98b3-753cd268db10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6969","original_object":"UniProtKB:Q99062"}
{"id":"9a0b1926-7869-411c-9ce8-8aaece13a49d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67CKV7X08G","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:df5dab3a-a6a9-40c3-beb6-607265aafe06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5615","original_object":"UniProtKB:P29274"}
{"id":"26800cc8-e8a3-421f-bc64-a96518dc49f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486355","predicate":"biolink:affects","object":"NCBIGene:5125","sources":[{"id":"urn:uuid:0a371ab0-57c2-4275-bb51-438816e83701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6564","original_object":"UniProtKB:Q92824"}
{"id":"ffc23210-247a-41c7-996c-e356fc9abe9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194402","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:f1d4d60b-137a-4f29-beba-0a1fcda3b647","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2199","original_object":"UniProtKB:P47901"}
{"id":"866900ca-bebc-4fe5-af6c-7c1ae24d2c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:268","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:a769d294-1887-4518-80a4-13f1922ef072","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1291","original_object":"UniProtKB:Q99705"}
{"id":"73fb87ff-6368-4146-a672-d618045dc967","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755185","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:98d63490-cd1a-43fc-ad89-cdfc28aa5047","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6194","original_object":"UniProtKB:Q9Y271"}
{"id":"7180fcc9-13d3-44e3-af95-5fc509977b0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90683","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:ee83e9e1-0f5f-4584-8fe9-8325694c1fab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7817","original_object":"UniProtKB:Q16539"}
{"id":"48b231d8-df0e-4d5f-a27b-f9fc9e816fb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:0db50309-7209-488f-973f-0321c8113ecd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:Q16832"}
{"id":"d12b730c-9430-44a4-9190-671bf0572026","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8044","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:de44a3b2-747c-49c2-b4f4-ee10c21d6f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8044","original_object":"UniProtKB:O96017"}
{"id":"e290c320-9f14-4174-9773-13812170b672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90936","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:337222ef-bce9-4448-9406-7782ddfcebe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7739","original_object":"UniProtKB:Q9UM73"}
{"id":"e8ee19d0-1913-4276-99f6-5fa634d96636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:de1cf878-a187-4027-a35e-d17a2fe469fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:O08858"}
{"id":"13376dff-de87-4d5e-a443-d5b63eed469d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BRJ718SA03","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:d98911ef-0893-4921-a278-3a81e8c3f89f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9003","original_object":"UniProtKB:P41143"}
{"id":"95a63c1d-91c3-48d4-9b98-9e56f2d71e4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64119","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:19492004-e7c5-4ca2-8d35-25ec4fbe21c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:958","original_object":"UniProtKB:P14416"}
{"id":"ddef8381-4b60-4d98-b509-4ba9e9bfaaeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10382597","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:d0da8974-d634-4c1f-9343-9fe6a0ed1964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3101","original_object":"UniProtKB:Q02769"}
{"id":"1e6797d8-c84f-4940-9efd-532f7a648e0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993643","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:1fbd271a-cec7-4f30-8b8c-4cf630321fff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12486","original_object":"UniProtKB:P11229"}
{"id":"329810e3-01a3-4c1b-88d9-0cf297374a11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:7e4180c9-0f47-4492-b783-7f1a8427dc01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P43116"}
{"id":"38ec596c-7293-4637-a376-bcee0c9430c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:171044","sources":[{"id":"urn:uuid:3ecac63b-bf4a-4e26-bc4d-3b1fd337acc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P30936"}
{"id":"e0863634-318b-48af-9256-84990f08c93b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27953","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:3ff2ff08-ea46-4a0f-a136-4c5449fb0ba2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6598","original_object":"UniProtKB:P22303"}
{"id":"3f3cfedb-e41e-4a37-9e28-f809fae23a73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189868","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:c5e94dc6-2fc7-4b7e-a8a1-662584a47a05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1614","original_object":"UniProtKB:P34975"}
{"id":"8868019d-f3b4-4f84-8289-0f6d51ca3016","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679538","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:2be8afe7-3c48-4160-8dab-5da5dfc90aac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11848","original_object":"UniProtKB:Q8NHX9"}
{"id":"c86ee585-cd15-4a1b-a1a7-a745003b820e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46226252","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:5bce3861-d55b-46d0-92b6-a5a69e898a1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3420","original_object":"UniProtKB:O15552"}
{"id":"483175f3-4145-45e9-af2b-d9f6c856c30f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10813088","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:63cb73d2-26e7-44e9-afad-18121fb7c376","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:398","original_object":"UniProtKB:P25099"}
{"id":"78a5b09f-dcdb-4acc-9875-f1044ecc66ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:2512256d-ea49-4451-aa0e-cff365710cb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2298","original_object":"UniProtKB:P15388"}
{"id":"59ff8f98-da63-4144-938f-4c637f9fa7db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:641H0Q518W","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:86d86a5d-e70b-4160-8cfe-c78db935ac02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13017","original_object":"UniProtKB:P04150"}
{"id":"46480cfd-93d2-4510-b5a1-68d596915b97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:63b054f1-258e-424e-b025-a578aefb110e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P32305"}
{"id":"af78cacc-d6bc-4ae3-a240-c6fc858df488","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:11539","sources":[{"id":"urn:uuid:9fc7b733-7afd-4bcf-9718-d2db25411d44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:Q60612"}
{"id":"0c06ac67-a3e8-40ad-98cc-8bc0cf0d84fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167657","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:1d2c4ff8-2f45-46d0-864c-8752d02b44c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8016","original_object":"UniProtKB:P49841"}
{"id":"da2f9b00-43d4-4817-98b9-85842669284e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4865","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:6f569ceb-21fb-4990-bee2-076eba8a1deb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4865","original_object":"UniProtKB:P25090"}
{"id":"6bac97e3-022d-417a-800d-323cd86ec137","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194548","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:102f377f-ed47-4456-9390-705b9fcad8bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:509","original_object":"UniProtKB:P08588"}
{"id":"d98ff86c-ea31-457c-b790-dbe6eb00aaf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:fbec0993-c727-441e-9f85-40332d3ad509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P35560"}
{"id":"cdaf0f03-a31d-4d6e-9c61-f8da6a03d576","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25226432","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:6810255b-2248-4419-81f2-c74cc1d31d79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8385","original_object":"UniProtKB:Q92831"}
{"id":"7d956be6-6b01-4822-bc9c-bff8c7b3e0ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11543746","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:f6bd4009-2899-429a-b374-8d7086604dbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8664","original_object":"UniProtKB:P06401"}
{"id":"a0fb31ed-1f98-4d09-b20d-b27c146f44b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817392","predicate":"biolink:affects","object":"NCBIGene:60432","sources":[{"id":"urn:uuid:8236be8e-b301-4f33-92f3-3d9d494fad48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1139","original_object":"UniProtKB:Q9Z0W0"}
{"id":"7595c348-0dfd-4f66-b603-c4a3d28418c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827347","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:efd2bf3a-c47f-4d3e-8d89-89681c806e0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5903","original_object":"UniProtKB:Q15077"}
{"id":"9a539c0c-31cf-4817-b0df-69e41571e5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15293210","predicate":"biolink:affects","object":"NCBIGene:6095","sources":[{"id":"urn:uuid:3b497af6-2f4e-4101-9c5f-a0b20e301c11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8906","original_object":"UniProtKB:P35398"}
{"id":"a079b9ff-cfa0-4ccb-adb1-89fe30f9b8cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081964","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:32378ffc-5ac1-4104-a95d-c18161df3ba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9886","original_object":"UniProtKB:P49336"}
{"id":"2996d8d3-3714-4aaf-8e6c-d7f630da8411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28864","predicate":"biolink:affects","object":"NCBIGene:259295","sources":[{"id":"urn:uuid:4af8549e-a414-41e1-92b4-abcd99bec757","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10930","original_object":"UniProtKB:P59543"}
{"id":"3dff8cb3-3d42-45a5-ad77-60d21cce5bc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64101","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:9ce369ce-bfe6-479f-a71b-6215d91e0fc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:24","original_object":"UniProtKB:P08908"}
{"id":"e3d84491-cfbe-4aa7-a4de-756bdc2d2738","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230832","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:daf81965-02e9-49f5-aa6c-6fe73affd662","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12576","original_object":"UniProtKB:P18825"}
{"id":"8651f5d8-78c7-427d-abfa-9df9b67cd7e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80229","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:194a0aed-6729-45ff-a8f4-252525b5f431","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:616","original_object":"UniProtKB:P24053"}
{"id":"43ede2a8-4950-4105-87bd-4d34cadc9f60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3361254","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:36adfa6d-4859-40c0-bef3-e7a79929c2d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8082","original_object":"UniProtKB:Q9NWZ3"}
{"id":"0e761fc0-4680-4b4f-9ffd-a0bc6148e74b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:a455e988-2c9c-4268-8f65-6a2ac1d8438f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:P29597"}
{"id":"8447d29e-120e-4ac9-9a87-3bdf504a9b25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31401","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:5ba15de4-8198-4ceb-8535-1c41de46f040","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7148","original_object":"UniProtKB:Q14432"}
{"id":"d49d8497-098a-471d-8c47-3165bfc3fa2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:788PET5SUA","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:c7b1ea33-a053-45ca-948f-4b37fc331f37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10427","original_object":"UniProtKB:P31644"}
{"id":"631c12ca-dbd2-4d85-ba39-02cb6ae7d534","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6074","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:a2909541-ff7d-4024-b878-55603721535b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6074","original_object":"UniProtKB:O60755"}
{"id":"5dfe03d4-1902-44b1-9e50-26aca1e88035","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95077","predicate":"biolink:affects","object":"NCBIGene:10765","sources":[{"id":"urn:uuid:e08f9316-401a-48f8-ae27-39b23f99396f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8979","original_object":"UniProtKB:Q9UGL1"}
{"id":"e00185ad-9270-4871-a85f-2989dbd7b036","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83527","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:b8604d5d-6622-4031-b17c-f6793c3a4722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7158","original_object":"UniProtKB:Q01959"}
{"id":"f00330b4-5ac8-4c29-8fbd-fcfae65b7ba9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47575","predicate":"biolink:affects","object":"NCBIGene:599","sources":[{"id":"urn:uuid:5629c286-193e-48b5-a5f1-ac5275db2d94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8320","original_object":"UniProtKB:Q92843"}
{"id":"c3d48c81-6a30-415d-9805-3bb1f621a06f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167669","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:044197e2-196b-49dc-addc-39c286266878","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11163","original_object":"UniProtKB:Q02127"}
{"id":"551cc3e1-6cb0-4159-812d-af8bcd7b73a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44222958","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:8f7639c9-8db0-482d-9da4-def0d1dd3a1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8214","original_object":"UniProtKB:P11309"}
{"id":"6a34f065-012a-4995-ae47-91c64174aa52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:f3244eae-13b3-4f69-83c4-80a4a6d313c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P28221"}
{"id":"c40347c6-ec40-4922-bfd5-9d05f60bcbb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145803","predicate":"biolink:affects","object":"NCBIGene:6510","sources":[{"id":"urn:uuid:c09d4fcb-2492-4bdd-b320-5f7f3b3ddfd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4501","original_object":"UniProtKB:Q15758"}
{"id":"561d0877-157f-4f0d-b4af-28ca96173d2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:40afe999-8ab2-4025-9a1d-526979d0383d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5387","original_object":"UniProtKB:P07550"}
{"id":"d6c1ba12-6ccc-4c38-963f-d7b1506d1e1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:21cebca5-e528-46e3-a5fd-9d3b860e8d11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P35348"}
{"id":"29e62342-bdcd-4760-b0f0-c9f73b50a238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9124","predicate":"biolink:affects","object":"NCBIGene:23547","sources":[{"id":"urn:uuid:2e197c46-0fe0-4401-9fce-2caec795bebc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9124","original_object":"UniProtKB:P59901"}
{"id":"52794ac5-ddb1-4367-9a34-4b63f70e5231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:4e2e59c3-78d0-481e-9934-9ee70b92bbb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:Q13639"}
{"id":"c9f1bdf9-7c18-4c9f-b5dc-efb3c9e770a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EPZ68T461K","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:4ab6c6b9-d426-4d8b-96c9-fecee96eb6ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10524","original_object":"UniProtKB:Q16539"}
{"id":"0bd911bc-e516-4646-9681-3d4d7283d619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155688341","predicate":"biolink:affects","object":"NCBIGene:84876","sources":[{"id":"urn:uuid:cc7e1021-f8b5-4946-9a24-1d8f5525ee43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13555","original_object":"UniProtKB:Q96D31"}
{"id":"205f7871-77ef-4180-87a4-895ff7147d2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102373294","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:9dd2b97e-1dc6-4637-ac4b-c7f65e6854cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11862","original_object":"UniProtKB:Q8TDD5"}
{"id":"d6527fb6-8492-4ed2-bc82-a44d1a131497","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:83942","sources":[{"id":"urn:uuid:bc0962bc-f6f7-4bdd-920f-c191f91f3e51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:Q9BXA7"}
{"id":"82ac0294-9bf6-4b54-aaf1-d7cde96e3e5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3244","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:d71dea92-00ca-43fd-843c-a36db2ebc24b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3244","original_object":"UniProtKB:Q13639"}
{"id":"aa0dde39-cf6f-43f5-8364-52f6ee9e5fa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9795241","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:6008afc9-88ef-4189-b1d0-69a7527ab2d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3094","original_object":"UniProtKB:Q02769"}
{"id":"5a6a9644-fe73-48c8-a497-5dce9b14066b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64089","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:e64f77ee-92b3-478b-bdb0-fc7eacf984a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9983","original_object":"UniProtKB:Q01959"}
{"id":"c5d348b6-99a7-4c19-8a9c-3a8602370c87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4A2Y23XK11","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:6300e167-68a3-48a0-a8c8-ec3903b8b1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10136","original_object":"UniProtKB:P43405"}
{"id":"5af55102-11ed-4023-9781-f8e33999b337","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136254272","predicate":"biolink:affects","object":"NCBIGene:28996","sources":[{"id":"urn:uuid:b1df8883-2563-445e-8997-945e5d21c7ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8171","original_object":"UniProtKB:Q9H2X6"}
{"id":"f61da1c2-d0be-46cf-976b-787f6d215eef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1131","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:ce3c8534-6973-497d-96da-81af9f1650dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1131","original_object":"UniProtKB:P43219"}
{"id":"b6cf1ddf-68a0-4099-a975-82a13ff9eb93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:71948465-0541-4217-bb20-fd3bb1430148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P08908"}
{"id":"74ddbe43-cf9c-4785-9a7a-b767ff4e30ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10041551","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:999e092d-85b6-46f7-8c1c-19810551551c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7537","original_object":"UniProtKB:P31645"}
{"id":"29c9aee3-b1ac-43ec-8aec-cba9a1d99536","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:6982532e-8077-4920-9463-a2849432adf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:Q9Y572"}
{"id":"5f150c3d-c106-4f85-b60b-a81b856b6dc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4329947","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:9b520ba5-1e40-4643-a5d9-67dd7e422748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5829","original_object":"UniProtKB:P21462"}
{"id":"378f0df0-a400-4118-a690-8d2ab6369dce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:169e54f1-683c-441d-8948-c10cdce8ea1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P13945"}
{"id":"5818fd25-995b-472d-b0f8-babf42471a15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5284330","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:755bc23f-6835-4e87-9b61-cb6967496b5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10327","original_object":"UniProtKB:P56726"}
{"id":"1d5a1788-362b-4199-8ca4-96f382b191e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5327339","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:d52b4d1b-edf0-4ffe-8d67-cdecb53037fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8628","original_object":"UniProtKB:P42574"}
{"id":"b9ea1cbf-d161-4666-8f9c-e5b7a39833e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2B218X5QIY","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:63f2ddd7-a914-41b9-ad96-e2b41a127cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7697","original_object":"UniProtKB:P46098"}
{"id":"7bc4cb77-3b5a-452f-a8e3-0d858ef49cdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:7830bc73-3fcf-4952-bb53-8f636adc964b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q9UHC3"}
{"id":"fb6aa98b-9940-41bd-9755-5ff9599b2525","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312146","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:986d91da-723a-4057-954d-f171a699f78b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1011","original_object":"UniProtKB:P24530"}
{"id":"3c424f57-6470-4a07-b30d-99b2c4b6d5fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231415","predicate":"biolink:affects","object":"NCBIGene:22933","sources":[{"id":"urn:uuid:a6abb336-f10b-4e70-a8c3-27aa7a4198fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9251","original_object":"UniProtKB:Q8IXJ6"}
{"id":"45711200-2d48-4b2b-9acf-5eb72c2af094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130961","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:a95bbd16-db51-4784-895c-44145f578395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2005","original_object":"UniProtKB:O08858"}
{"id":"2ededa5b-ddb2-45a2-88b4-410edc1871e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352756","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:2b243b94-10d3-404f-bf7d-88d339168334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3091","original_object":"UniProtKB:Q02769"}
{"id":"df706196-792f-426c-bc2c-04906a8b3903","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93132","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:a6b2f2d9-b460-4496-9fd9-9a53198b9c43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1385","original_object":"UniProtKB:Q13255"}
{"id":"7ff014b1-006a-4a70-8119-5bdb8cab2e68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2325","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:0187994f-afe6-40c3-b121-7f4ce8d1fe2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2325","original_object":"UniProtKB:Q9H2S1"}
{"id":"286817e3-f490-4aa1-9dee-ccbb930a4078","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5295","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:e9385be3-d7e5-476a-a57f-aa4913d14c1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5295","original_object":"UniProtKB:P42574"}
{"id":"407c6dbb-84c3-45a1-abd4-2c0ea0999382","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91658","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:332dec07-e78b-435b-8c27-0a731ee7b230","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9750","original_object":"UniProtKB:Q13546"}
{"id":"725c905a-2d9e-428d-851b-3fd54bb4b786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5689","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:3ea5e121-9b71-438d-b47c-c790b66b4d94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:736","original_object":"UniProtKB:P21554"}
{"id":"156d3b85-1e10-4b43-805d-67b69dc78d5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18524489","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:ac156485-9f2a-48c7-9d0a-a284c1eb7ef9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10275","original_object":"UniProtKB:O75762"}
{"id":"31bc45fd-d767-42cb-977a-c3983a4fd33a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17688","predicate":"biolink:affects","object":"NCBIGene:57053","sources":[{"id":"urn:uuid:2bce6e0a-644a-402e-bb85-28b3e8033e8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2585","original_object":"UniProtKB:Q9GZZ6"}
{"id":"6687953d-f587-4148-a955-e735819f0280","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85980","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4ded1d80-bac4-4ad1-80d2-41443eebeabc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7691","original_object":"UniProtKB:P35372"}
{"id":"934f2b4c-82e6-413a-91c8-0350fbc58559","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129786","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:653fdbec-a2e7-4f7e-b79d-655104cb79dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3276","original_object":"UniProtKB:P08485"}
{"id":"c5d75f40-4e93-40c7-a824-cc57487fac4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:074b597c-547f-4218-a9ab-b5232df7cd9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P28223"}
{"id":"b15ad230-21c2-4874-9d34-51be69c6037a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:480c02fe-60eb-4b2c-bcaf-dc193fa92ade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P28222"}
{"id":"ae3aafd2-5c7f-45e9-90e5-c69240146556","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91194","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:9dda5817-1d54-4801-8da0-599de8f62695","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2907","original_object":"UniProtKB:Q9UBY5"}
{"id":"20a7b842-1c42-4dd9-abae-eb9158e2c376","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3E4SQ96PCJ","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:791380d9-99af-4629-95bf-db22a8bdefd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10276","original_object":"UniProtKB:O75762"}
{"id":"2bf1253b-eef7-4b5e-957b-7d7a59c42a48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:8001903","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:ebf3921b-4bc7-4449-89af-a010d3ecb906","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10034","original_object":"UniProtKB:Q13133"}
{"id":"6cb883cd-6714-40eb-a733-4670ee28f87b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58761009","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:d5e4c44c-3649-4403-8006-cb28db216724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1848","original_object":"UniProtKB:Q62035"}
{"id":"ad8b0d7e-4d81-400b-8e9b-a62883d8787c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124090478","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:a5f275d6-98a5-4822-a1f0-86c5b495a341","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10458","original_object":"UniProtKB:P52333"}
{"id":"ea695e87-a6e8-4514-becc-a50552b2384e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:975AT1P9J6","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:f1ff07e5-41bc-45a9-b5df-bf93c2f5c213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11308","original_object":"UniProtKB:Q13546"}
{"id":"e72d7a9a-0e6b-4bff-9cbe-fbc9dce0c358","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46179018","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:e6508e90-7e41-44ba-a1a3-52a10fcec9ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9367","original_object":"UniProtKB:Q86V86"}
{"id":"4fc5df3e-83ff-4092-a7c4-2e08f05dba14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3DGD69C6PV","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:cdfc159e-d40e-4fbb-957e-aad811cc1c7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7741","original_object":"UniProtKB:P00533"}
{"id":"c75763ad-d3bd-48b1-bede-ba9b257eb1c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81391","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:2e546f9a-c7f6-4718-8aaa-09f13d6ac47a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1267","original_object":"UniProtKB:P58406"}
{"id":"1832fb15-02cc-41a8-b54c-ed614969e40b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32015","predicate":"biolink:affects","object":"NCBIGene:6557","sources":[{"id":"urn:uuid:8489cc86-c982-4bca-bec9-be2f8e3d8675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4742","original_object":"UniProtKB:Q13621"}
{"id":"1ab241ae-704d-44b7-b2e2-5c1b637f510c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2026","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:0014900c-c51b-4f3b-a0c4-6fad457aa667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2026","original_object":"UniProtKB:P35346"}
{"id":"20171dc8-2a97-4920-a783-90cdb05c3245","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92283","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:a909999e-c7b3-45da-9cb6-ee1fb853924f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2926","original_object":"UniProtKB:P21453"}
{"id":"2f478183-fc8b-4985-a079-2e1bf360636d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95341","predicate":"biolink:affects","object":"NCBIGene:55589","sources":[{"id":"urn:uuid:6cb63169-0ee2-4905-9eec-9a6834c522fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7792","original_object":"UniProtKB:Q9NSY1"}
{"id":"05f5910d-0b4f-4450-af75-d47b77f766e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:74682303-e061-4001-979b-57da8f694469","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P18825"}
{"id":"9e477483-8b7f-4011-a8f4-cf4b3e96886d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13288","predicate":"biolink:affects","object":"NCBIGene:79813","sources":[{"id":"urn:uuid:212bf514-1dd4-4b3a-8ac0-0003f3630a40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13288","original_object":"UniProtKB:Q9H9B1"}
{"id":"09a8d5c9-5554-4877-85e6-c7c164c0c6c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Y1PJ3VG81","predicate":"biolink:affects","object":"NCBIGene:4929","sources":[{"id":"urn:uuid:a8b646a6-e7f4-4dbe-b156-6b947f68029a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9860","original_object":"UniProtKB:P43354"}
{"id":"61fc57d7-9b47-4a88-82ad-0b0e4b91c421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900912","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:e7c1710c-aa31-4108-ace5-d050a5acbd36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11893","original_object":"UniProtKB:Q9UHD2"}
{"id":"6329b335-5516-4220-96dd-ef9120215948","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126523866","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:82d35957-0183-4a74-889e-75d44da8df09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3696","original_object":"UniProtKB:P32246"}
{"id":"d545970b-ee4e-4057-95d4-b1c370552e94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188061","predicate":"biolink:affects","object":"NCBIGene:158584","sources":[{"id":"urn:uuid:8759eddc-f8c2-479e-a80c-6693d5938f8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4339","original_object":"UniProtKB:Q6GMR7"}
{"id":"a72282f7-64d3-4ad2-87ec-6d01b7d124f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:d8328551-1b49-4acd-9f78-f881a66f8fac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P14416"}
{"id":"260ee321-222f-4a4d-b79e-40ab564da736","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:bde1258c-37af-466d-913e-67cdce2daa93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:P36888"}
{"id":"cd79e331-1671-46e4-9a48-97406b497c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:440141","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:b9ee8c7f-bfaa-493a-b052-d83e459fb0aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1717","original_object":"UniProtKB:P47900"}
{"id":"b3f9ca56-bb51-4c0a-868f-59fba5342c27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10450926","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:10984212-d19b-48cc-a62a-507df280892e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9610","original_object":"UniProtKB:Q08499"}
{"id":"962718fb-dee7-4781-9aa1-427bf333372b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:b38cd469-344d-4f96-856e-723aac21c166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:O08858"}
{"id":"79ba53d3-2857-4db2-bcd0-bec03bf6ee2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:829","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:a68653e5-3bd9-49fc-af49-123e5af9cdac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:829","original_object":"UniProtKB:P25025"}
{"id":"4946984c-dba0-4ec9-bf66-cd4425a172d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:0b0c87eb-ebdb-46db-92b7-564825dcfd80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:Q9HBW0"}
{"id":"ba6b103e-2523-4bf3-894b-fad072ffabd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YXX2180047","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:7975da45-b5fc-45de-8f3d-20aaad2b43ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9765","original_object":"UniProtKB:P00533"}
{"id":"5bc88f90-cd60-46cd-a884-13b2f0dabd05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993640","predicate":"biolink:affects","object":"NCBIGene:54112","sources":[{"id":"urn:uuid:3d15bef3-ab37-4dfd-8673-98c94b9da924","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12395","original_object":"UniProtKB:Q9GZN0"}
{"id":"b3b3b452-269a-45f4-bb2e-b6072d33f40c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2220","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:ef900dfd-6360-431f-bacb-02b7e484b005","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2220","original_object":"UniProtKB:P30559"}
{"id":"45e220cc-58be-45dc-a413-cb9c272038bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:9a2148eb-b458-4039-a153-a4aa3f852d2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:O00329"}
{"id":"435387da-48f6-4f9b-a39f-47536cff6a10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34310","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:37236433-7122-46bc-8080-963099e5f006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2750","original_object":"UniProtKB:Q13133"}
{"id":"bf7d7d98-9b94-4c7b-9701-a1639ec153ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:855e4415-3030-4f92-8350-1f2c433c8c19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P29275"}
{"id":"8b4c9b8d-bbde-4e65-b086-f7b534b93a11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:56666","sources":[{"id":"urn:uuid:a3a17d2a-41d1-4479-b6bf-9e8edb818e20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q96RD6"}
{"id":"4b2daee0-ec3a-44ac-8249-747398ea7dc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31684","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:c6f3f61a-d51e-43e7-8ac8-a06c77db85f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7399","original_object":"UniProtKB:Q08493"}
{"id":"a59e89c1-914a-456c-9fbe-fddc85d5e4be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11715556","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:0ee82dd6-2593-4d03-897f-8b59a6d3bb5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5801","original_object":"UniProtKB:P49019"}
{"id":"65d4b9e4-66c5-41e4-9588-c3bdf37d36ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2219","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:3fc414c4-c16e-4450-9d89-204fcef1d30a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2219","original_object":"UniProtKB:P47901"}
{"id":"6388599f-cc3b-413d-90f4-acc087d43e47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RAX5D5AGV6","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:09474301-1c6d-46fe-b33e-c44b9981116d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10615","original_object":"UniProtKB:P30518"}
{"id":"06a381c9-f31e-43b9-b025-6860e93ceee9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13924","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:588c4993-415f-470c-840b-d3fd348a56f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13924","original_object":"UniProtKB:P43220"}
{"id":"85fd51c3-515a-4e93-91be-a5ab5cb8ea12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53027","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:dffc857c-b0b0-484e-815b-1e5560edf724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3413","original_object":"UniProtKB:Q15722"}
{"id":"ea3b6ba8-9b76-46e0-85fc-96e8f9d88671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155296190","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:fb9ba0b2-c94c-45be-b3b7-0924232628ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13492","original_object":"UniProtKB:P07949"}
{"id":"a19c80fc-1533-4e22-9a63-f866a60729a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:851","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:62ce1f25-654e-4103-9da7-92167fa63230","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:851","original_object":"UniProtKB:P61073"}
{"id":"ae623f96-3225-415a-830c-d7f5ba433e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5886965","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:b13df24f-879d-4ebc-84e5-a96421f7ec73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5818","original_object":"UniProtKB:P43116"}
{"id":"9cd74aed-9938-47d6-96a0-90a94d0b688b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2560","sources":[{"id":"urn:uuid:2cca8be1-a60d-492c-b6d7-3e49504822a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P18505"}
{"id":"a46dd04f-52c4-494a-9c72-34b316bafea7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164852436","predicate":"biolink:affects","object":"NCBIGene:7003","sources":[{"id":"urn:uuid:e63d5b36-745c-498c-bab2-62e33aca9acd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12814","original_object":"UniProtKB:P28347"}
{"id":"3cab4e9e-5775-46ee-a742-0abce0d2d559","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2553","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:8443785f-e49e-4b6c-9e05-d441f3005ebe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2553","original_object":"UniProtKB:P63142"}
{"id":"a282f5f1-94f2-46c5-8828-d577225b53ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:8aaf14a1-06a2-44f1-9c4b-937c8b5a870b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9WTR1"}
{"id":"4cc440cf-9642-43b3-8406-895a71613b64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25015677","predicate":"biolink:affects","object":"NCBIGene:2241","sources":[{"id":"urn:uuid:f0365661-c506-418b-978e-4823ecf6aa14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9403","original_object":"UniProtKB:P16591"}
{"id":"0bda6293-2c26-44d7-af08-081e13f10d22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3822","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:d304279c-a8c8-4151-b0fd-4cb9a5f730ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3822","original_object":"UniProtKB:P21452"}
{"id":"f0ad002d-7eba-4011-bef0-1dab6d39f016","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O812716S9E","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:f898d79a-218d-4eed-bcd6-b2f21fed1fa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9306","original_object":"UniProtKB:O43613"}
{"id":"e89bf825-d5ad-4046-b6b9-8c0de110ed21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1311","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:527a2212-dcf1-4b7c-a762-2489c22850d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1311","original_object":"UniProtKB:Q99705"}
{"id":"74279d86-f57c-451c-a082-600874fea76f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18152","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:82380bf5-8bcf-402d-92a5-b5911da09391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13074","original_object":"UniProtKB:P04798"}
{"id":"808eae38-4729-4076-b5b5-1094957f22f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:858f6e50-c66b-4a5b-a027-f3c9339782ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P47898"}
{"id":"a7aad649-e271-493d-b6d8-499cabd85199","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J57O328W4W","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:e3419c8b-cb80-48c4-802e-7da03e4fb523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2307","original_object":"UniProtKB:O43526"}
{"id":"50080e4f-8d08-475e-b103-5fb5c8146303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452170","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:844c0510-37ae-4b55-8aff-cf7f9006f34e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8190","original_object":"UniProtKB:Q96GD4"}
{"id":"781b3c7e-54a3-498b-8cb3-339f92905e3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50381","predicate":"biolink:affects","object":"NCBIGene:7357","sources":[{"id":"urn:uuid:2b45b533-643c-4268-a1bf-66737df04a84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4841","original_object":"UniProtKB:Q16739"}
{"id":"2b76f162-739d-4b58-9232-87406c515077","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139223","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:e294e667-69d1-4dd8-9f67-6b3d65277e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2912","original_object":"UniProtKB:Q9UBY5"}
{"id":"c41c00c2-6eca-4919-a41c-abd764a19d62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587558","predicate":"biolink:affects","object":"NCBIGene:9020","sources":[{"id":"urn:uuid:56b10ab4-7d56-4115-9b95-bd0383b73bfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11595","original_object":"UniProtKB:Q99558"}
{"id":"f131c8d1-39a9-405a-a2b7-3188b45f3207","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59404585","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:1dd39bbd-6194-44bb-95ae-227799b07d84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3802","original_object":"UniProtKB:P49146"}
{"id":"66faf176-f52d-44ed-b365-f69b2793999b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3H8GSZ4SQL","predicate":"biolink:affects","object":"NCBIGene:4352","sources":[{"id":"urn:uuid:40371c48-71bc-4556-a499-e5eb281b88ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9953","original_object":"UniProtKB:P40238"}
{"id":"1d67239f-08d7-4f99-ad69-e073c39222ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:30f4bc75-46f0-48c0-a9dd-0a9d94c2cde4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P22607"}
{"id":"15a4f41e-ab40-457e-8448-3888ef36a02f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131409","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:2a03343f-1675-463e-acf9-f967c49f2b64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6086","original_object":"UniProtKB:O43603"}
{"id":"7fd6428f-936f-4f1b-8b7f-4a6a39fd5de8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:477f2be6-f46f-4481-b057-fe3d8675a917","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:P31422"}
{"id":"d740c171-5222-4868-b028-4ea325f0d6a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:4c65e56f-7df9-44b9-9ca8-41e75d8421f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:332","original_object":"UniProtKB:P08912"}
{"id":"0ed1f319-2a51-4a13-9125-2505572efb17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2184","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:de69fd70-e0f9-408b-8e87-789016e6f861","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2184","original_object":"UniProtKB:P47901"}
{"id":"70c359e2-d23f-474e-b464-0763d5ba0446","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2H6KVC5E76","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:1f50be1c-1841-4855-b8b5-903a7343219d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4277","original_object":"UniProtKB:P34903"}
{"id":"4eac06f4-402a-45ed-92ae-ef214eca5d4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8980","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:41793f64-145d-450f-a426-9de6e87aa3db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:194","original_object":"UniProtKB:P28223"}
{"id":"16b8814f-1806-4e24-adc4-f0399469d209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3357","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:af30c047-a61b-4ecc-98ab-6cb532720509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11093","original_object":"UniProtKB:Q6RI86"}
{"id":"3c9b5f11-7f46-411a-8096-c447b2df6df4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8651","predicate":"biolink:affects","object":"NCBIGene:12775","sources":[{"id":"urn:uuid:c25063c2-f5ff-438f-a7be-cd7580ef3e59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8651","original_object":"UniProtKB:P47774"}
{"id":"c76c586c-18c5-45a8-93a1-9dfe0d9faf51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44397277","predicate":"biolink:affects","object":"NCBIGene:9252","sources":[{"id":"urn:uuid:7b642354-b2f0-43f7-96f1-840354cb53e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8131","original_object":"UniProtKB:O75582"}
{"id":"171d9dd2-076c-4cae-a9d6-13c040452c8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91832","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:93d39576-19b6-42b5-a9c6-d0dcac58b86b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3285","original_object":"UniProtKB:P25099"}
{"id":"fc639e5e-33cc-4336-8e05-30018acb539d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3191600","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:b73ad910-dc60-43d6-8730-2afeb2b3da83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5520","original_object":"UniProtKB:Q13304"}
{"id":"d6470003-21b5-4fb3-afdb-0603fd608bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2AF560R2HC","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:f587b6ae-2d6d-40ed-a197-360609deaaf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6061","original_object":"UniProtKB:Q02769"}
{"id":"0d1ef0b7-3028-4c88-95e2-c86a7c710801","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154593283","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:27a9b624-4c78-43e4-aeaf-eed0b09063cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13740","original_object":"UniProtKB:P00533"}
{"id":"1e0f6458-a14c-4778-89d4-9efe4d84925a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42724","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:d499a6a5-2870-48d4-84fa-4e74dfe73acc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2146","original_object":"UniProtKB:Q923Y9"}
{"id":"5a33dccb-8aec-4bb1-8990-39dd3700cd46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10058807","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:fc773ab5-8aed-478f-845f-7074dc1a84e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1276","original_object":"UniProtKB:Q9H3N8"}
{"id":"d247d79b-9ade-4be1-823e-530302df8e61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:14cea426-ec07-4a12-bd8b-9b8af1ac21da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P50750"}
{"id":"beb60409-3870-4c9b-8ce0-4d3e8791b963","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:8016395","predicate":"biolink:affects","object":"NCBIGene:1195","sources":[{"id":"urn:uuid:f3423e89-889f-4b80-9c7e-9451b32fe544","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12974","original_object":"UniProtKB:P49759"}
{"id":"4c00f50a-c2df-4f96-bcfc-d12d7266e514","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49662","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:ec4ec0d8-b848-437a-8697-38287c822998","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1909","original_object":"UniProtKB:P37231"}
{"id":"8927c3e1-613d-4405-aa06-3751a046a0d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4934","predicate":"biolink:affects","object":"NCBIGene:1441","sources":[{"id":"urn:uuid:3386fa5d-492b-44a6-a329-da1a6d6457a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4934","original_object":"UniProtKB:Q99062"}
{"id":"e70f474b-d070-4830-bb47-32c679655b83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441295","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:32c2a80e-8b49-4ac6-9bc5-3ff2849425e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1863","original_object":"UniProtKB:Q62035"}
{"id":"094f6431-c633-4f4f-a597-75f2b2f26c60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132427688","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:4ae4dd0f-ef56-4d08-80d3-b3bcece63759","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9810","original_object":"UniProtKB:P49841"}
{"id":"5cdb3d87-3afb-4c10-b271-26b1963593fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144672","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:3a4b8b22-d645-4f38-919e-f5515702cb7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11060","original_object":"UniProtKB:P29597"}
{"id":"39981dba-11ed-4be2-83c2-429836189d07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q257O24H4J","predicate":"biolink:affects","object":"NCBIGene:837","sources":[{"id":"urn:uuid:ed839e92-3869-46cf-b0a3-6b6452bf0463","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9034","original_object":"UniProtKB:P49662"}
{"id":"cea890fc-6ffc-4717-ba14-2a39fa5ae0f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132145761","predicate":"biolink:affects","object":"NCBIGene:27163","sources":[{"id":"urn:uuid:1a271590-e219-42a1-81fe-77863c2a8bae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10120","original_object":"UniProtKB:Q02083"}
{"id":"106dc74f-d9a5-410c-98fa-b6f60912f1d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229220","predicate":"biolink:affects","object":"NCBIGene:6098","sources":[{"id":"urn:uuid:e2d38b49-55c8-44f8-9927-b176337b60c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10316","original_object":"UniProtKB:P08922"}
{"id":"b3c694b3-19a9-403e-87d5-a47c37583dcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73349109","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:53f71774-37b4-4e02-a238-dbc778f17397","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1706","original_object":"UniProtKB:O43614"}
{"id":"ecdce1f4-6394-4e94-b920-3310348c99d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63619","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:ccdb6584-8000-4d70-bc53-25a976a127d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2561","original_object":"UniProtKB:P22460"}
{"id":"9121392f-40de-421a-a1f9-b5a45543303e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:639d3b41-6c54-4ce0-b265-43f6fe2ddfe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:P06493"}
{"id":"657eaf9b-5e97-4ea6-9ef7-8cbd83b2cd0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190962","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:86e7ab0d-b81b-47a6-abb9-a9b6fb6d3dcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2460","original_object":"UniProtKB:O35433"}
{"id":"f2bd54cc-558e-453c-83b9-d6b162643757","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146018369","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:49b84b93-548f-4851-af66-ae4eb9c769c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11401","original_object":"UniProtKB:Q13526"}
{"id":"479a3ec7-5284-4b69-829e-bdcf6d106b23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KKV299446X","predicate":"biolink:affects","object":"NCBIGene:1889","sources":[{"id":"urn:uuid:0fa16217-414d-4c2b-b5ad-736b64ef4837","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6506","original_object":"UniProtKB:P42892"}
{"id":"4d0f16bc-3903-4f94-95dd-f674ea2bebb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136041","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:69a60dec-6e4b-4b1c-b127-954a5b31f79e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9395","original_object":"UniProtKB:P31639"}
{"id":"6fc5a149-6f88-40e4-a42a-e1b3c20978a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:0e831ded-08fb-47b2-88d0-cfc41456cb9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P43252"}
{"id":"0fad3b3f-e24f-4078-8359-4a469dcdfe82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13285","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:4a00e0a7-3565-4a4c-886d-4bdfe62f23e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13285","original_object":"UniProtKB:P0DTC1"}
{"id":"bfa675ed-2170-4e73-9bc3-9d11f82ef090","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:727ff8c0-016b-45ad-ad6e-b861ff114dda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P31645"}
{"id":"fdb3ed5a-8420-4a7e-b6b5-64e177ef51e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3509452","predicate":"biolink:affects","object":"NCBIGene:84876","sources":[{"id":"urn:uuid:a27ae126-2d37-41cd-bdec-e88e73c9dbc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10041","original_object":"UniProtKB:Q96D31"}
{"id":"230e77f9-610f-41d8-be48-6325f65e4a65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:f29145a2-4047-47e0-af24-69f1bf6099ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P31388"}
{"id":"2d3b4421-72d5-450f-af38-0946267a4d92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:ac073499-48ab-4270-87cb-e65f106b0647","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q9UGI6"}
{"id":"72119b4b-b0e4-4e74-b65c-a8baeb75e858","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73777063","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:ea8ad217-0db5-4ce9-8a1e-d53bd0ba1061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8418","original_object":"UniProtKB:Q5NUL3"}
{"id":"b4232689-97a0-4a93-a186-94e625a458d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57778011","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:c8b7beed-582b-4c18-bceb-c591969a3556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7578","original_object":"UniProtKB:P37268"}
{"id":"7f0e3dc5-18ef-44bd-8cbc-94a5b7c1b600","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15KFN616FK","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:f88cb0df-164f-4e85-91a7-a0d76b24c6a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11200","original_object":"UniProtKB:P28482"}
{"id":"f068f622-b74d-4c84-8fad-8dfefa1ee98f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FF33NL9U5G","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:c78ad8a3-8826-4ef6-9e2e-7bfc5e587132","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9060","original_object":"UniProtKB:O08725"}
{"id":"c7e6ee77-b308-48c6-9bcc-7b63e528ea7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129776","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:e35ce229-10a6-469d-9912-df24ec33999c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1364","original_object":"UniProtKB:P49286"}
{"id":"8541e9b9-00ff-4727-9858-4728524e4dcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76PND635L1","predicate":"biolink:affects","object":"NCBIGene:2241","sources":[{"id":"urn:uuid:44586c5e-c75f-48c0-ad0e-931ebb8d3913","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8137","original_object":"UniProtKB:P16591"}
{"id":"a917a002-6a90-4c84-90f5-32925931126a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10296414","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:a5b16f30-b565-4dbc-8d2e-81ec8bd5df20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:76","original_object":"UniProtKB:P08908"}
{"id":"a9a46270-079e-44a0-9a32-deec102ae1fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10394861","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:fd3a5de5-a9f4-4337-91ca-32e54f1a1581","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:669","original_object":"UniProtKB:P30411"}
{"id":"730fd4a0-e830-4b38-962b-fd7bc9c8854e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60782","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:8b7602e9-bd10-4e6f-a0ab-91ef8c317073","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1940","original_object":"UniProtKB:P43115"}
{"id":"1a812e0c-4532-47e3-a1b9-37d58363a435","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7661","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:ce37e81f-2eaa-427c-98a8-263e424f1d99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7661","original_object":"UniProtKB:Q12809"}
{"id":"326325f6-6c16-499e-82df-b6ac2c67bda9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47520","predicate":"biolink:affects","object":"NCBIGene:1581","sources":[{"id":"urn:uuid:2c2e8906-44bc-4426-aa20-8d5c36b9a74e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8871","original_object":"UniProtKB:P22680"}
{"id":"d05e8482-3b52-4c2b-9d5e-eec61479766f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7F5QGV49GL","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:3f1154bf-085d-49a0-ad84-75fa6f7052f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7337","original_object":"UniProtKB:P49768"}
{"id":"f2dab2e8-c4de-4a5f-a580-8e7680190c2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125340","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:b0cb00eb-60ea-4e62-b286-c5ce75a9c3df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8061","original_object":"UniProtKB:O14965"}
{"id":"93e9f35d-f122-4828-90a1-9592e56cff22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1045","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:53487049-d656-4d8e-af78-a81a8bdd01c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1045","original_object":"UniProtKB:P25089"}
{"id":"a41e7c6a-49cb-4275-9138-d2df0651e436","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118556943","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:c1daaa61-e7e1-46b8-bb3d-dad575c46a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10365","original_object":"UniProtKB:O00329"}
{"id":"ff1c7c88-aa58-45ae-94ea-5e3af28f8762","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2012","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:e84b66d3-1eae-41fc-bda5-4d0c59f8aac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2012","original_object":"UniProtKB:P31391"}
{"id":"55a4b708-78c6-4513-8a6e-ef15b3ac958b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5115445","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:c9c7faaf-69fb-4da6-b0b3-d9a09481365b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:159","original_object":"UniProtKB:P28223"}
{"id":"6a16ce7e-3cc8-4956-b89a-0f61040d02f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2324","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:5914e22f-0e1b-477d-898a-aa0da4cac367","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10159","original_object":"UniProtKB:Q13936"}
{"id":"92cbbf0e-ac5c-46cb-9be4-0af8ec8b17f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78539","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:912776af-5e81-442f-ba30-fc20e4292591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6462","original_object":"UniProtKB:P12821"}
{"id":"5f2b138e-31c3-48e0-ba61-eb6a2a365281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4466","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:af86b264-276b-4d5e-b74d-d2cb9ab7b08a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:521","original_object":"UniProtKB:P08913"}
{"id":"4d44ec98-3be5-4165-864e-7b50d712d726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5640","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:05614c3c-37b1-4ca3-af31-a121be4f7abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5640","original_object":"UniProtKB:P30874"}
{"id":"d2edba13-201f-4c76-aeaf-0e70f79f33af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9995893","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b97b00bb-d92e-4b71-ac86-95252eb7c20c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:65","original_object":"UniProtKB:P08908"}
{"id":"3e461b17-9719-4591-9b91-9602f614feef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:7660fa49-b0fd-4403-9ed3-29618d7eed02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:P10721"}
{"id":"08897868-617d-4914-9e5c-8bda6dd0864c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8GU4PSP29","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:e9f7902f-fb77-4de0-b229-a6f4bd3ee137","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5270","original_object":"UniProtKB:O76074"}
{"id":"bf655177-7677-4f8b-a6e9-7d922febda27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J1J4P3PQZD","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:af6469ff-1fb9-4da8-84c8-6009aedf3137","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6902","original_object":"UniProtKB:P30556"}
{"id":"c7ce7bf2-0c90-49e1-a178-ec5ad6b7092c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31073","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:aa8f20a0-3014-47be-829d-a044034ca62c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4264","original_object":"UniProtKB:P42261"}
{"id":"ce109f5f-170f-4c30-99be-1cf83cc0f673","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733032","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:39355211-80b3-4ae8-895a-d609e2ceaa91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11279","original_object":"UniProtKB:P04201"}
{"id":"a679fe85-204a-4d40-8951-d26d98ce528a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3611","predicate":"biolink:affects","object":"NCBIGene:22045","sources":[{"id":"urn:uuid:9c904bb9-a9d1-4847-ae6b-5fe968c5a776","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3370","original_object":"UniProtKB:P21761"}
{"id":"1ffd57c4-0a50-4943-a915-64f942bea28b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57412074","predicate":"biolink:affects","object":"NCBIGene:1675","sources":[{"id":"urn:uuid:ea744530-e467-411e-83a7-1ee2ca659290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8296","original_object":"UniProtKB:P00746"}
{"id":"afdc7b67-d2f1-410f-a3c7-d488d6cfcf80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1571","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:8d06239e-12d0-487a-9732-0e6c0b53ced0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1571","original_object":"UniProtKB:P30989"}
{"id":"b2bb2f8f-1144-462c-896a-60546b92664e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233158","predicate":"biolink:affects","object":"NCBIGene:10858","sources":[{"id":"urn:uuid:fd2c8e89-af25-4b6e-9c6c-cadf0ad6d06e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11517","original_object":"UniProtKB:Q9Y6A2"}
{"id":"b2948380-99ca-41ac-8c96-42ae3d57086d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:e383d13b-3df7-4382-847e-69d686acd8ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:O75762"}
{"id":"f8d846a5-2b90-4757-bb76-f8e2e2e2d4f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7514","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:e8470801-0f36-47f2-88d0-fbeeb8667f27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8993","original_object":"UniProtKB:P22303"}
{"id":"5b252a1b-a772-4ac4-b2f7-6f400f5daa09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:773","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:7f3d8aa8-1447-455a-b86d-50804e7b3bde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:773","original_object":"UniProtKB:P41597"}
{"id":"b2d81e50-99d9-4548-9a34-a9679b5b9137","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71291068","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:5e5e4996-6c49-4be2-ba12-328cfd6b98be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7513","original_object":"UniProtKB:O60885"}
{"id":"1f2729a7-a49c-41db-b667-9dbfb8f7f2ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:759","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:7a033c4a-a480-4407-8706-622dda25b039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:759","original_object":"UniProtKB:P49682"}
{"id":"50ab3f57-b43a-461b-861c-18d7ad142c97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:59WCJ0YNWM","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:e133d678-b806-48b9-ac95-d29d69a4dcf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8689","original_object":"UniProtKB:P50406"}
{"id":"e8705e7c-32f6-485e-8853-7fb9d156b854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699459","predicate":"biolink:affects","object":"NCBIGene:6098","sources":[{"id":"urn:uuid:9e2e9b06-c4d0-4bb2-b6ab-c255ee1149c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11198","original_object":"UniProtKB:P08922"}
{"id":"7d5986a0-1761-461a-ba0a-2768f7fbac75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:53949","sources":[{"id":"urn:uuid:f951fb7e-296e-4a4b-893e-c65c91cf0a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08911"}
{"id":"671c12e8-711b-46a7-8bab-3e9fac7973fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZPX6CRU43V","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:b42f81dd-541d-4ce1-bd83-054ad606cde0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11409","original_object":"UniProtKB:Q00534"}
{"id":"480b5cfc-7a77-4634-bfb1-b24fc470673e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10047720","predicate":"biolink:affects","object":"NCBIGene:1144","sources":[{"id":"urn:uuid:82e372b7-0f29-4942-a9f4-2e728b3d9089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8883","original_object":"UniProtKB:Q07001"}
{"id":"55f1bf19-52dc-4b89-927c-dfafbf257c33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2081","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:43e86bd7-b426-428a-a11f-53549920a326","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2081","original_object":"UniProtKB:P31391"}
{"id":"f32a97fc-ac81-41cb-8e1e-1cad8e6d3d91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31348","predicate":"biolink:affects","object":"NCBIGene:7298","sources":[{"id":"urn:uuid:f7bb5a3f-f0d9-49e1-b2d7-b2e8ff987b70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6799","original_object":"UniProtKB:P04818"}
{"id":"35204cad-0b0c-4289-a537-1adf45c4b88b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:48e6a084-453b-49b3-a3a3-70e603738d16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9BX84"}
{"id":"a88ed3d1-53d1-4800-8e4c-09609048a377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZA45457L1K","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:277debed-b7bb-424e-a0fa-71df71850b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9752","original_object":"UniProtKB:Q06187"}
{"id":"7b83e2a6-ed97-462f-8099-744bb22dd5fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:337f153a-5b88-4e36-a618-42576efe641f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:P52333"}
{"id":"58052492-e928-4690-b583-de5f8a88e000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233291","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:6907a32b-2864-4d00-9814-6789c77454ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2111","original_object":"UniProtKB:P29371"}
{"id":"6569c87b-4bb7-42d8-86f4-400e6eb6506c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:cae9322a-d98c-4a6b-9bd3-909aed291243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P49841"}
{"id":"d9a5226b-ec1b-4bd3-857c-c4bd86235378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38545","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:3732fcc2-3d48-43c0-b8a4-3f08488d3d54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2954","original_object":"UniProtKB:P51639"}
{"id":"289fbfae-15cb-4e6d-8f75-7f9620aebe21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42371","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:faf64eed-745a-46ff-bd9c-b85f688b326e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2822","original_object":"UniProtKB:P03372"}
{"id":"03dc903d-fc52-49aa-bb86-9b8fe98a1673","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155555842","predicate":"biolink:affects","object":"NCBIGene:586","sources":[{"id":"urn:uuid:968fa51b-190e-4bbc-a981-bf7d86bfc9f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12232","original_object":"UniProtKB:P54687"}
{"id":"13256efd-c928-4e79-b95b-259ef99afabb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:32ab8af8-ac8c-4c04-898a-c09bc3439e61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P21918"}
{"id":"5e394130-f4dc-47a2-bd89-4e3fc715d329","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z02T66W92D","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:0e5f01e1-0745-4162-bae2-297e35112478","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:427","original_object":"UniProtKB:P29275"}
{"id":"779cac5f-d1cc-47fe-8be7-53521abef991","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A5VAY2U3R8","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:a35b5a8d-93d5-47be-9f35-9120540086b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2567","original_object":"UniProtKB:Q17ST2"}
{"id":"302fc353-7dba-460a-8c3f-0821a82e90f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18346","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:2b461c20-c0d4-415c-b238-f30fd822593b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6412","original_object":"UniProtKB:Q8K424"}
{"id":"3f446b6f-7d74-49c4-818a-39ff345f401f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3659","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:fca11374-748e-4b9e-82e5-1df02d86da8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3659","original_object":"UniProtKB:P25025"}
{"id":"895445d1-2f3f-40c2-b560-87432bcbd514","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817401","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:61fbd042-d7b2-4dfa-81e1-bc7f0cf456b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1286","original_object":"UniProtKB:Q969F8"}
{"id":"53a46b9d-15bc-4d10-8fe3-228f0c320979","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310998","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:6b4572f4-8cc9-4730-b1f3-5dc5ea00595c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1928","original_object":"UniProtKB:Q62053"}
{"id":"a8b103c1-af34-4944-8878-e63e2b942193","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KV1M7Q3CBP","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:253ae55a-d6bc-4a22-a5f2-02632d4edd43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10630","original_object":"UniProtKB:P00519"}
{"id":"1ac0d45d-40ff-4fe6-84ef-7d8a4ba68341","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1341","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:1c54895f-35c0-4f04-9d5a-f39128352ddd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1341","original_object":"UniProtKB:P41968"}
{"id":"6d0a683b-24a1-4473-b3cb-a3c70bae18b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:cc7e0dbd-3783-4f2c-8dce-087d338e6455","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P34969"}
{"id":"8dd6abd2-2e0e-4e49-a5d4-e5a138abf305","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9929033","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:53c9c52e-ec8e-44f2-998f-1ad38fc0ffb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:233","original_object":"UniProtKB:P97288"}
{"id":"32c383fa-da60-4936-8b60-6ec900d04011","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6311","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:caed5dfb-3e1d-4769-a46f-fcd526894a29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6311","original_object":"UniProtKB:P35414"}
{"id":"bb0fefb5-c2a8-4839-ab4e-ee96b053fac0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:1f0838c7-733f-4c89-9138-b003b5e003f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P50406"}
{"id":"614bf330-eccf-4bcd-a83a-00abbe42c8e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2027","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:42cd7cf7-c220-49ce-ba2a-70eeb8c07252","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2027","original_object":"UniProtKB:P30872"}
{"id":"e65edcb5-e1d7-4dfd-8a25-5d07caa511e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817416","predicate":"biolink:affects","object":"NCBIGene:2832","sources":[{"id":"urn:uuid:bf70cf61-f592-4df8-b583-f8a30bf07570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1497","original_object":"UniProtKB:P48146"}
{"id":"9e88ad90-1c6c-4b97-92bf-418181914fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3E4SQ96PCJ","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:be9e291a-c0da-416f-ab2e-168d3a50c1fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10276","original_object":"UniProtKB:Q6RI86"}
{"id":"28cb81e9-e60b-4778-81ad-e06dd8db7091","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:16ad7264-615e-4dfb-9e2b-3e3574799cb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P31644"}
{"id":"0e6df3c7-ec32-4ea6-9f5e-5a53ea85bd4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90279478","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:da9bf4ed-506e-4e7c-b184-24bdd4d30219","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13070","original_object":"UniProtKB:Q07817"}
{"id":"7188de63-30b2-491c-98f1-b87151810996","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HR4RD5RBJ6","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:5ad1845b-c577-4c40-b3e2-cd7e09a8d69d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13264","original_object":"UniProtKB:P04150"}
{"id":"f2837528-5a64-47fa-b179-aa5d3217e992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155145010","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:e3827cc9-3110-4f07-b18e-93c11f7a555f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11599","original_object":"UniProtKB:P40763"}
{"id":"0f3d6d3e-e60a-4a4c-8244-63eaaf37fd28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8597","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:cc9cac15-26c2-4531-b804-64d5e4bcaf0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7285","original_object":"UniProtKB:P23975"}
{"id":"b51bfa91-e70c-4fad-8912-e290c77e671c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180392","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:826bbb64-65e2-4e7f-ad64-143e9faa78bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2463","original_object":"UniProtKB:Q8R4D5"}
{"id":"87a2ead5-803f-449e-b38a-93f01f5f91bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1B419P24AV","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:38954cb3-4981-41eb-a365-c8824984dd2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1701","original_object":"UniProtKB:O43614"}
{"id":"7d11930f-0136-46b6-9b80-0cf728a3bd0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311299","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:47b5c244-b7d1-4e96-8b78-ea64a217ab80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:235","original_object":"UniProtKB:Q13639"}
{"id":"ed6c1471-6f18-4f43-a414-cd19c788e770","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8776","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:2c743280-8ac1-4eda-a48e-c50ed71a5d2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1234","original_object":"UniProtKB:P25102"}
{"id":"043ec328-814e-4e5b-a169-bfb3565acf5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486536","predicate":"biolink:affects","object":"NCBIGene:55617","sources":[{"id":"urn:uuid:f7105c42-df84-4cba-90a8-5857952defd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8853","original_object":"UniProtKB:Q9H6P5"}
{"id":"569dae82-e523-41ac-be3e-4e7e2e7985dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32297","predicate":"biolink:affects","object":"NCBIGene:5137","sources":[{"id":"urn:uuid:f1e41898-e1c0-4bcc-8ae5-4c9e6d47a277","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5285","original_object":"UniProtKB:Q14123"}
{"id":"a9785c28-91f6-453c-ba92-62070445e798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:957d32d2-f1e2-4f73-82c6-c6ff25f8ddce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:P06493"}
{"id":"c1c9d1de-0f7b-4342-8138-83af74b52fb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1156","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:c954b6d3-2b28-48b3-8245-c23432ccd253","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1156","original_object":"UniProtKB:P23811"}
{"id":"714bee09-65bc-4cbe-bce3-5d43234e9cdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8876","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:42cc7348-6ae4-4715-8c6f-f56828259703","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8876","original_object":"UniProtKB:Q15059"}
{"id":"5dbcf1b8-90f4-4ae8-a616-6db32d4b3f60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10282223","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:ab9573d9-b809-445f-a1eb-50fca96d4131","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2909","original_object":"UniProtKB:Q99500"}
{"id":"10ff56a6-9ce2-448c-ac83-5accdfe9f612","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:746f716a-8bb9-4b39-ad5e-5737b03843a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P47898"}
{"id":"eb4a7567-28e7-4d80-804c-2d02c5cffaa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:f6742aa1-58e5-463d-b4f1-d987a80b4a27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:Q9NYV8"}
{"id":"8d4c1cd2-4ddc-446d-9dbe-71c29e5cc6a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135460621","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:c63c12e8-19e3-4f7b-8c2d-1fb01f9a6902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13563","original_object":"UniProtKB:Q5XXA6"}
{"id":"64c209c0-2b8b-4007-a83b-979b79c4f6b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817517","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:0978e9f4-176a-49af-887f-50be2b75633c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11439","original_object":"UniProtKB:Q9UKP6"}
{"id":"47f6526a-7997-41f1-abc0-ac89ab6087e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45378170","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:1040f88f-b549-4464-9099-af767b5ad3ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12616","original_object":"UniProtKB:P42338"}
{"id":"ce11bcc9-fa8b-4a14-aed4-f15dba204644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:5f0f31f3-0415-4169-b3e3-7fc7156df935","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P32304"}
{"id":"ec1f36e1-c7a4-426b-a7cc-2ef519633599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50861","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:b66c17d1-77bf-4f57-9ae6-62129033455a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5820","original_object":"UniProtKB:P43119"}
{"id":"67361206-7621-4596-82a4-d13bd0dad75f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:51701","sources":[{"id":"urn:uuid:3013c59e-b50c-4423-b735-79bf6f5024bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:Q9UBE8"}
{"id":"6b0dc98e-9591-4b92-9880-2f4ad4f619d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11515548","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:18fc7cae-13ea-419d-976c-4ef209ffb9dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6355","original_object":"UniProtKB:Q13255"}
{"id":"6000280f-61fc-4ef2-a3ee-3d0e046d850e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155166738","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:ecfa16c3-0de5-485b-81fd-6c86fc92c10d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13639","original_object":"UniProtKB:O00329"}
{"id":"eb36c016-7f25-434f-9e68-15dac17423cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91934096","predicate":"biolink:affects","object":"NCBIGene:953","sources":[{"id":"urn:uuid:f2bb0b04-ce53-4b43-aac0-addbe65d4158","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9023","original_object":"UniProtKB:P49961"}
{"id":"a52157ce-7d80-42e2-8fce-29af5570f521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:73c9fe3f-93cd-4fbc-9199-0ecbf440ac79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P50406"}
{"id":"7ce7ff2c-7c62-49d7-9bd7-330a0a99feb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138059681","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:9a4b9b67-8b4d-41f3-bc8a-08f9dccc4750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10535","original_object":"UniProtKB:Q06187"}
{"id":"d3486ee3-2b3d-47bd-a78a-22bebe9a10a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47381","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:b28c505a-a0f3-4985-89f0-85d7febcde08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2714","original_object":"UniProtKB:P35354"}
{"id":"44714b7c-1a01-4028-8e53-1780ec8b9f89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121427554","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:daba3bf0-2dc6-461b-8209-8ab28a47aa74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12384","original_object":"UniProtKB:O60674"}
{"id":"caa3e84d-360a-4a85-8004-b65ffc3c156a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8426","predicate":"biolink:affects","object":"NCBIGene:29465","sources":[{"id":"urn:uuid:e0bdd0c4-81e7-4cc4-b746-5c699d9a93ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4357","original_object":"UniProtKB:Q9WUD2"}
{"id":"8bcef1af-f097-4f0f-97de-f09da70c9e5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135530","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:b288a59a-f48d-4fea-aa2f-76b5796f82f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7483","original_object":"UniProtKB:P08912"}
{"id":"9412b56a-708d-4516-8b27-b6651144566f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124991","predicate":"biolink:affects","object":"NCBIGene:9376","sources":[{"id":"urn:uuid:57c7be9a-3c0b-4758-a340-5980f08ce51e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8798","original_object":"UniProtKB:Q8TCC7"}
{"id":"cd704543-30b7-4eae-9bb0-003ed80e1e82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64191","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:95fc5a31-65cc-4bcb-846e-6aa1de01b219","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:44","original_object":"UniProtKB:P14416"}
{"id":"0354ca92-7d62-4b91-a6af-cc4407f4a054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93589","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:41524a4f-3689-44b3-8c1a-ed3293f71745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1580","original_object":"UniProtKB:P30989"}
{"id":"4e11f786-5988-4bd4-a564-bfdda389c731","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1519","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:c3f6ad15-509e-45ee-b1e3-86be6e9e4217","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1519","original_object":"UniProtKB:P49146"}
{"id":"f243799f-a6f0-4dfe-86b0-eb475e5cd920","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:3c8f7369-0b7e-4596-85e3-b24e1a76b22f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:P61793"}
{"id":"d3bc3092-0099-4461-b16f-6acef8ff8565","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95021","predicate":"biolink:affects","object":"NCBIGene:7298","sources":[{"id":"urn:uuid:09f9368d-8911-4644-afa3-1243b7b71aa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6837","original_object":"UniProtKB:P04818"}
{"id":"d0f3d743-82c1-4466-b218-a4a55fdd503a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34623","predicate":"biolink:affects","object":"NCBIGene:26379","sources":[{"id":"urn:uuid:65ee6059-1c42-4073-8052-d3934df3ab22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2831","original_object":"UniProtKB:O08580"}
{"id":"2e523629-795b-4417-8fbc-7e0188ca8c2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:ed1850b7-5ad9-44cb-aae1-9065425a4518","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P36507"}
{"id":"0ef30a5a-1a0e-41f9-9c56-32a2c661d589","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94306","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:de7de4d2-fb9d-44ed-b509-c032f88d277e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9664","original_object":"UniProtKB:Q969S8"}
{"id":"42097c0a-4bbc-4b1c-9fc0-cc047115c1a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817437","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:6a101e23-385b-4a11-8672-f7b79b7f1a64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2268","original_object":"UniProtKB:P32215"}
{"id":"19bede5d-ee31-4b41-b9e2-2c5828c1fe9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:631","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:a9f0b858-c7b4-49b3-8ee5-40dceeb5e93d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:631","original_object":"UniProtKB:P32247"}
{"id":"8957f089-087c-40b7-935e-2bd5bddb1cca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44365325","predicate":"biolink:affects","object":"NCBIGene:13809","sources":[{"id":"urn:uuid:765194ab-0758-4423-ae2e-a38a93c404ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8630","original_object":"UniProtKB:P16406"}
{"id":"5c8a2744-bac3-4c23-857b-41fc3a4c0155","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947067","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:13793301-ea92-4bd8-b651-6f20060f18c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3104","original_object":"UniProtKB:P37268"}
{"id":"68ff62f1-b8d3-49c7-b824-9ae553fe4726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J2L7Z273SG","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:381bbf7f-b475-4097-996f-662ec361a164","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9131","original_object":"UniProtKB:P15056"}
{"id":"851b4fd8-7527-4b2c-9dd4-367f288701b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4806","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:b64dc034-6158-40b9-8f1f-3747bd9325b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7002","original_object":"UniProtKB:Q09472"}
{"id":"b02508f4-996f-4f0a-8c11-dfd26b0d4831","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70934541","predicate":"biolink:affects","object":"NCBIGene:5062","sources":[{"id":"urn:uuid:86069698-50dc-4f7b-828f-c5b8a741bf69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8939","original_object":"UniProtKB:Q13177"}
{"id":"267097d5-7c56-42e6-86fc-e4bc7de1364a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8979","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:145268bc-bb19-4f68-ac9f-ccfbeea94040","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:192","original_object":"UniProtKB:P28223"}
{"id":"8ad8d987-be9d-4b92-bcec-bd21264a5253","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900912","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:bbecb84d-70aa-4503-8eee-b031b6c11e11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11893","original_object":"UniProtKB:P29597"}
{"id":"8ca3dbbe-a638-4ae4-8e97-54eb78185e0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:f36803e0-da26-4942-a758-64021b4711e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P06493"}
{"id":"91aa2458-2efb-4d00-a550-e1060ef14e40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2195","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:1b44d91f-83f9-4f1c-a1a6-db6a40a6da16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2195","original_object":"UniProtKB:P30518"}
{"id":"ce841145-cf59-4910-8ff7-26d1ff948485","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4324257","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:98e2a3e3-1d97-475c-aea6-2a27da7935fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4080","original_object":"UniProtKB:Q12879"}
{"id":"51e5424e-4516-412b-91e3-b004532c9427","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73442763","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:fe8e69de-2f9e-446d-8e8f-c9790542c636","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9448","original_object":"UniProtKB:P35414"}
{"id":"a6c71511-6a1f-4542-833b-60ef26b0a02c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11970792","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:70220a83-41a4-4000-89ef-9913ec3c2014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:13772","original_object":"UniProtKB:Q6IQ20"}
{"id":"dd61f9c2-2410-40c3-8264-98fadd5b28e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:87501a48-be97-40ac-a1e0-05aa4cfecb88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P28221"}
{"id":"242bfae4-aa2e-43c0-b981-ef2247a78bda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71464","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:adb9972a-2efa-4330-969a-37d0c22a37bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3622","original_object":"UniProtKB:Q8TDV5"}
{"id":"6fba66f7-1555-4d16-9d66-ca082f904387","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:24145","sources":[{"id":"urn:uuid:84d2d9a8-04f5-4952-8678-1ffd6303b5eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q96RD7"}
{"id":"ff0f1241-8870-46f9-901e-cabc6e6920e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10568125","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:f4bd3b9d-72bb-46c3-9ba6-9298de47c974","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:399","original_object":"UniProtKB:P25099"}
{"id":"a2a15ef8-aab5-431a-8af0-4a8c7d28c743","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:a117f59f-41cd-456d-965d-13d6bf5cbfc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P42680"}
{"id":"2ced7c1f-2426-4f3f-a2fd-e0e6b6a437f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44434752","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:83a67126-43c6-45bd-9f26-ca0ad56aa896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6445","original_object":"UniProtKB:P31424"}
{"id":"d7d5a815-359b-4455-9330-5c55214f11b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27775","predicate":"biolink:affects","object":"NCBIGene:25265","sources":[{"id":"urn:uuid:9b016d8d-28d3-46bb-8552-c8bfbec6ad6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5454","original_object":"UniProtKB:P49651"}
{"id":"16dd7219-42a3-4ff3-b098-15f66dc85f6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3045225","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:769e8937-7fc3-4b0f-8542-83c78ff45a27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:230","original_object":"UniProtKB:P28335"}
{"id":"9910f9b4-357d-46f3-bfca-1658bf017331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:dab7b2fd-717c-461b-bb43-f994757cb8ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P35367"}
{"id":"309d88d9-e11f-4f85-a58b-56ed69fdcfa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50169","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:cc91a49b-49d4-4079-b4ec-ff6ebb93520f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4108","original_object":"UniProtKB:P47869"}
{"id":"390a6a60-595d-4034-8d01-ae0a2b69800e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6127","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:6eb6c298-233e-4969-9d7a-70e30c09b6c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6127","original_object":"UniProtKB:P47211"}
{"id":"315bc782-a342-4437-92c5-d81f7ecdf26a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1530","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:a750e5c0-fcc9-4b41-9ded-7be6e24bf336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1530","original_object":"UniProtKB:P25929"}
{"id":"576018e8-591e-4b21-be32-5a581a7c7c62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118627280","predicate":"biolink:affects","object":"NCBIGene:2744","sources":[{"id":"urn:uuid:15125d5a-c94c-4e89-a8cc-908b5312896c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12712","original_object":"UniProtKB:O94925"}
{"id":"96af0543-5025-41c6-8595-eb48852f54d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:5478","sources":[{"id":"urn:uuid:5eb07b92-4e26-49a2-8f42-55e51123f59f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:P62937"}
{"id":"f9479604-a9ef-4238-b363-c86b5ad9d10b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:f95abfff-79cf-4b00-ab8a-aa15ca154ae1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:Q9Y5N1"}
{"id":"07a95586-70bc-4612-9b23-35d28ade6bdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:149553242","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:adf47c6c-2a2e-42da-97a3-d3df3c3f9c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13354","original_object":"UniProtKB:P10415"}
{"id":"68721087-4785-493b-a391-e98441578a18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5337173","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:7cb38fcd-3717-4da4-875e-b9de647757e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7664","original_object":"UniProtKB:P56696"}
{"id":"5485bd2f-d2a4-425c-bbe9-b7ad1cbc3364","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:f72fc9e0-121e-4419-88d5-bd53bd02977c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:P17948"}
{"id":"eb2558f3-d458-4d2c-976b-3a995ab3fa4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3698","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:9fe47ffe-f357-4f64-90b7-36d4fd17f5f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6459","original_object":"UniProtKB:P12821"}
{"id":"b8d90706-b1a1-4f9d-94e3-c3cde6bf8e34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53385780","predicate":"biolink:affects","object":"NCBIGene:4056","sources":[{"id":"urn:uuid:336efc00-f109-41d4-8496-e666beb1bfd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9556","original_object":"UniProtKB:Q16873"}
{"id":"7bab4be6-2ded-47fa-aa51-435b9ba2065d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817395","predicate":"biolink:affects","object":"NCBIGene:60432","sources":[{"id":"urn:uuid:9219ae35-fb51-489d-9bb2-73bebc2507e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1142","original_object":"UniProtKB:Q9Z0W0"}
{"id":"c79ffec5-d145-4948-88ab-7616daf2fc4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53325462","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:9264f46c-e062-48d3-a853-684479f9deb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3272","original_object":"UniProtKB:P08482"}
{"id":"ee5b74a4-4df8-489e-9775-7afe2020eb86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:96302757-7705-4306-a7c3-f1b67ddfdfe7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P30530"}
{"id":"7457c36c-c1dd-429c-87f8-73521da8f7e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30659","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:a44f9b6b-c3f7-4b45-9107-beb3a2ea4e17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6951","original_object":"UniProtKB:P10827"}
{"id":"df21827a-24c3-4f05-91cf-807d76136035","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156855755","predicate":"biolink:affects","object":"NCBIGene:7005","sources":[{"id":"urn:uuid:aaaf92f0-e54e-480b-91b5-45ac626f51e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13367","original_object":"UniProtKB:Q99594"}
{"id":"ca94bb4e-3e00-4705-838a-6a175cdaa24e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:490095","predicate":"biolink:affects","object":"NCBIGene:1548","sources":[{"id":"urn:uuid:e8808bf7-cdef-46d2-afbd-a2285e59e037","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5180","original_object":"UniProtKB:P11509"}
{"id":"64415604-bf9b-4886-b9b6-24d50280f731","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:8a3cef93-6f59-4e22-85ae-02c20d221204","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P28647"}
{"id":"2c5bc47c-6b68-4109-b76a-f75b720d2abe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24893978","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:cd243710-cf01-4bf5-b3bc-12d64c283585","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8872","original_object":"UniProtKB:P08684"}
{"id":"c8cf188c-b0b4-48aa-b1de-e0e62822130c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49858118","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:93545754-3592-45b3-bc17-f9728e5dbed6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6224","original_object":"UniProtKB:Q14832"}
{"id":"24ed6ce1-31b7-4832-b09f-cae083effb24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81527","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:f142c980-fa09-40dd-bddd-706c0a4bbdd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1631","original_object":"UniProtKB:P35372"}
{"id":"d4813232-9781-4c7c-a09b-b93a08b55896","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44351001","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:03f5d84a-7574-45cf-868c-3a8f2fdf4313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1507","original_object":"UniProtKB:P49146"}
{"id":"97336bcd-17fc-4da6-98c0-8031d1d7b0bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324619","predicate":"biolink:affects","object":"NCBIGene:6539","sources":[{"id":"urn:uuid:b24948ba-68c4-45aa-8de9-644f9951370c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6513","original_object":"UniProtKB:P48065"}
{"id":"94e89d3f-acb0-4b4b-9653-4d49c29f75ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3738","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:688c5e43-ae14-44ec-a240-fd5416b10432","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6063","original_object":"UniProtKB:P35367"}
{"id":"64b87dbb-03e1-4e63-94e2-24c8e6f10405","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136003","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:254805ad-5882-487c-959e-332f70a4eb4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1605","original_object":"UniProtKB:P41145"}
{"id":"8547cb38-e36d-4fe9-b3f4-817c551caae4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13818","predicate":"biolink:affects","object":"NCBIGene:8621","sources":[{"id":"urn:uuid:f6ff2122-bf5a-4279-b25f-11c023630caf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13818","original_object":"UniProtKB:Q14004"}
{"id":"27c566fa-a1b0-40b6-8ba6-83c00cf4ff2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:cf67d5bf-6918-4327-9c63-70bafc9ceb9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P0DMS8"}
{"id":"2f2e1dc2-1774-4732-abf5-c31fb5c3dd5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3972752","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:40b999e6-e596-4fb8-95e2-a492ab6e9ba7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1415","original_object":"UniProtKB:O15303"}
{"id":"88ff4b72-9f2d-4143-a05f-06714a00abb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163196302","predicate":"biolink:affects","object":"NCBIGene:10568","sources":[{"id":"urn:uuid:aa0d9dc4-194a-4d95-8932-83ad7803cae6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12115","original_object":"UniProtKB:O95436"}
{"id":"964cab0b-15ea-455e-a8f7-23cad1e4f84b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135466","predicate":"biolink:affects","object":"NCBIGene:715","sources":[{"id":"urn:uuid:b3c40342-921c-4950-9eee-eb8f7031183e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4262","original_object":"UniProtKB:P00736"}
{"id":"1a0f52bc-927d-4bae-b6f5-29ce1b648193","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95058","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:85f13db8-4665-4498-a3ef-1915b0a84930","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8763","original_object":"UniProtKB:P49137"}
{"id":"c05c2473-edcd-40c1-8cbc-fe4ff3b167f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43602","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:384a372f-2b95-49c7-ab5b-1e8f9c617562","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3435","original_object":"UniProtKB:Q96RI1"}
{"id":"d4dc7e47-db68-425d-8593-634ab06a6a8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135552","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:77156e16-7024-42a4-8a4b-4f59a3cd55ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:243","original_object":"UniProtKB:Q13639"}
{"id":"8fb15432-8052-4d6a-848b-a1be92712dcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137038","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:6a558bcf-a87e-4f46-b2fb-825f0dc991a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2901","original_object":"UniProtKB:Q99788"}
{"id":"4647572a-6e9b-4192-9cbf-8542ab749943","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:5136","sources":[{"id":"urn:uuid:0d6ee9f9-b8e2-4e62-a222-424e245d5c1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2351","original_object":"UniProtKB:P54750"}
{"id":"fd8d351d-b116-4243-8c43-83474099a8a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JGA39ICE2V","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:43d49d4c-0b58-4a5c-8252-d15078ca7e7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6889","original_object":"UniProtKB:P07766"}
{"id":"ac98cc6f-b4a5-4a30-9ad5-5f5ae710d2f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947064","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:6503b583-7c1f-49c0-a12a-a55d52d21b55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2913","original_object":"UniProtKB:Q92633"}
{"id":"bdca48dc-8869-48de-9354-509db9a19685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47782","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:8d700466-2c82-42b5-bd3f-c171affec6be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7551","original_object":"UniProtKB:P31645"}
{"id":"d6766b75-dbbf-48ee-b74f-d20565c61b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14231197","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:102366fd-138f-4cd5-9352-774e988a656a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3154","original_object":"UniProtKB:P14324"}
{"id":"215df8ed-2078-4274-9096-753dcc18cb34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15663484","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:30bedac9-d460-45bf-8bfc-36867952f743","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3009","original_object":"UniProtKB:P04035"}
{"id":"f9377c26-2fab-41f7-8bd9-f85ef033def6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10254379","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:b4aa9de0-5894-4753-9f1f-cd918229ae16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:630","original_object":"UniProtKB:P32247"}
{"id":"24cf11f8-f2b0-47f6-9e18-b177151f7671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1575","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:97185a07-df86-4067-b537-04ad674a3bd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1575","original_object":"UniProtKB:P30989"}
{"id":"ed04c3d7-433e-4ad8-86ba-9bd0bf443030","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92728","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:74da9050-2c7b-4f77-9d6f-1843f36a5347","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1434","original_object":"UniProtKB:P41594"}
{"id":"120458b8-b2a7-4054-92c0-aba15ccf82f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1824","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:a0f7b03f-8eee-4b9c-a844-640081625e96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1824","original_object":"UniProtKB:P49190"}
{"id":"6aee7e26-5afc-46c4-9746-29084ea268f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78432","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:18d1f7b6-5e3f-4f20-93d7-6bcf30014851","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7397","original_object":"UniProtKB:P36888"}
{"id":"650322eb-a1fc-416c-945e-e7fda2061bba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177406","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:afd12ce3-0f2c-40f3-b249-373016968772","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3443","original_object":"UniProtKB:P37231"}
{"id":"d10d3db5-f584-4824-80f5-6c81a8aee62e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9U3GT3353T","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:698b4693-c798-4592-98bb-447c61b50663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1624","original_object":"UniProtKB:P33535"}
{"id":"4d953c7d-f4e5-487e-9aee-17a12ea82b4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:25187","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:ceda0607-6949-42b1-b0e5-e3a69f900052","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2430","original_object":"UniProtKB:Q8R455"}
{"id":"4626eeb5-4116-4a89-8088-18efc0a69665","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:259b5c33-43a3-4edc-8541-590279e891fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P35916"}
{"id":"42c58bad-6678-4969-b2a3-daa0af6f87de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:d7dd416b-7438-445b-b41f-8dab66008217","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P08912"}
{"id":"fa880065-6664-434b-8e4a-c13009bd2cbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:e7276d85-709d-438f-b658-df63aa87b45f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2291","original_object":"UniProtKB:P46098"}
{"id":"eb872a3a-ddb6-492e-944d-2020154b4b2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:f8b36065-747f-4cc3-9cac-d921f10d556c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:P42338"}
{"id":"ea65d510-b7ce-4ded-934e-89aafddcd250","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232895","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:c58e5310-e0d1-4a34-b717-476be56755fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4211","original_object":"UniProtKB:O75762"}
{"id":"63200cf0-5507-4405-8e89-44ba7e557e56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8499","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:ffa4f4cf-af5e-4048-bcbf-5ec9894dd5cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:564","original_object":"UniProtKB:P13945"}
{"id":"5160de6e-09b5-40c7-bc72-3c26a69dc053","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2208","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:59f2b490-2fe2-495f-affb-62f250095c33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2208","original_object":"UniProtKB:P30518"}
{"id":"6007154b-dce8-457a-9557-06d2217fa603","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136538","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:c9c03172-6744-404a-bf9f-3e46d915e98f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4186","original_object":"UniProtKB:P78348"}
{"id":"45198913-4537-4ef6-a205-c42f4728a74b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17263","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:735695ce-2a16-44fb-af44-21dcccf83537","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2818","original_object":"UniProtKB:Q92731"}
{"id":"ac2bf865-f528-4523-a9fc-d56b88249274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439089","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:efe37ec7-9421-466d-821d-e412d5c0b218","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:443","original_object":"UniProtKB:P28647"}
{"id":"60cf960a-dd4e-4d35-b645-bc2f0aba4868","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18152","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:2576a01f-105d-47dc-b8bd-eb436d2e4dd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13074","original_object":"UniProtKB:P06213"}
{"id":"3b8febfa-aa5f-42b0-b47c-46fb85cbcd6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10146183","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:001b76e7-bfe9-469b-9fdb-7944d1f96e94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3742","original_object":"UniProtKB:P25116"}
{"id":"a2c55c91-dcff-4b2e-af77-aaf34f46893d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13253","predicate":"biolink:affects","object":"NCBIGene:43740570","sources":[{"id":"urn:uuid:bdc48cf9-25e1-4f82-88ba-4c947ecb3be2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13253","original_object":"UniProtKB:P0DTC4"}
{"id":"87d4232a-dbd7-48e1-b31a-909b0ffbe894","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312396","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:7f17d4a0-5ab2-4b81-9813-1f8944ae3c12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12396","original_object":"UniProtKB:P04629"}
{"id":"8098567a-d70b-4059-b82b-570df5784e4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229233","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:d02ccbb8-128a-4b2b-84e0-57cac39cbc6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9559","original_object":"UniProtKB:P52333"}
{"id":"fbcfc39d-5b41-4830-b4c3-66e229aa2ca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O9H5KY11SV","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:91aa10d8-1c5c-4020-8a02-3253d0812876","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10883","original_object":"UniProtKB:P07711"}
{"id":"eda93761-66bd-4149-9754-2f18213c283d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114697","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:dc18e3d3-54ba-41b0-b12f-d3f808dc2065","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:513","original_object":"UniProtKB:P23944"}
{"id":"451ed824-b792-4d37-9ff1-cc2259ff2b01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:157049304","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:73863500-1d27-4ae8-8500-98f1b0b6e40b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11843","original_object":"UniProtKB:Q8NEB9"}
{"id":"375a6d13-3c86-4371-ab00-c3af10a451d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6956","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:16564700-696f-4025-b28e-7263729966d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13149","original_object":"UniProtKB:P35372"}
{"id":"28a7dd1a-e270-4871-bca2-03c215d27e12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:975eecb7-7d55-46da-917c-78d6cf1dd297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P28335"}
{"id":"42af7a2d-8e55-439a-9ba5-a0e7a678ea34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10124","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:192594f7-966c-4ce1-8566-af23b3449a46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:60","original_object":"UniProtKB:P28566"}
{"id":"b3198317-a483-45dc-9a0e-008307b11351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889873","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:7bc84b5a-d360-44ae-9625-565fcc11fc7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3068","original_object":"UniProtKB:Q02769"}
{"id":"74472149-933f-46bf-8df4-525922043b20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755108","predicate":"biolink:affects","object":"NCBIGene:4883","sources":[{"id":"urn:uuid:29204e4d-f9a4-4d5f-8fc1-85d2ac923496","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4870","original_object":"UniProtKB:P17342"}
{"id":"658a6a15-5f69-4af4-92b8-92dbdd2f4f45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2WTV10SIKH","predicate":"biolink:affects","object":"NCBIGene:5313","sources":[{"id":"urn:uuid:b21f37e0-6d1c-4d3e-8341-b62255d54b81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10473","original_object":"UniProtKB:P30613"}
{"id":"564bfbf7-16ca-4836-90a1-bbbb9f323627","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6954180","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:df16af82-ab2e-400f-87ba-244458863882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:286","original_object":"UniProtKB:P08912"}
{"id":"40b70721-318c-4211-a7f7-a993ad7d3767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115107","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:2adaadb8-5a6e-4e9f-9c76-dfcfe82a99fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:952","original_object":"UniProtKB:P14416"}
{"id":"2689446b-55e8-42c0-aac7-f9a65b284d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:29465","sources":[{"id":"urn:uuid:ce8e0aa8-a758-4939-9c88-661f460a7f1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q9WUD2"}
{"id":"e8e297b0-9c76-4f0c-8d36-e82270525ef2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73386890","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:fd1833f9-c6b4-406d-95f6-23de31e1a03e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12706","original_object":"UniProtKB:P53779"}
{"id":"0552b0e5-75ab-4043-8263-1438e6b17293","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11606263","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:57d35dbb-774e-47a8-afcb-fb549d9bd81c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3187","original_object":"UniProtKB:O95749"}
{"id":"c6e829a8-5928-41dc-9e66-52b8d32453ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312144","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:296d7698-239b-4b56-ac06-8e3a0a1f8605","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:275","original_object":"UniProtKB:P31388"}
{"id":"3eb6a3b5-50b4-48b3-b66a-7a4f0b380dd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91342","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:7de67b56-3595-42eb-84a7-a661306444f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5978","original_object":"UniProtKB:P49841"}
{"id":"0df38ae2-050f-4146-9b17-0ac22d4e9c96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32087","predicate":"biolink:affects","object":"NCBIGene:309212","sources":[{"id":"urn:uuid:0f74fc8b-b23a-41f8-bd71-b89260eb419d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1911","original_object":"UniProtKB:Q6XKD3"}
{"id":"138df536-cef3-4345-b8a0-13b6271f10d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:c69221de-12cf-4b86-b5e9-76c94abbe015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P32305"}
{"id":"437e5be1-3a2b-4750-b453-a66ee70edaaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:06a31240-2739-4e50-84a4-9bf02f44627c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:O00311"}
{"id":"7b9e20cc-5045-4647-b68f-e3095ca5cc0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46192505","predicate":"biolink:affects","object":"NCBIGene:10420","sources":[{"id":"urn:uuid:664a1d66-b861-40df-a737-02d0202e4964","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8117","original_object":"UniProtKB:Q96S53"}
{"id":"c4fdafcd-0351-4d3e-ad90-371c14cdd12c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:2268","sources":[{"id":"urn:uuid:e5690f38-dbe4-4454-84ed-28bb1c086f56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P09769"}
{"id":"b2859d9e-fa9b-40a7-9833-1c000eb8eaaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13292","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:dc92f857-633d-44f2-8120-863d087a79f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13292","original_object":"UniProtKB:P40763"}
{"id":"a276b7f8-7f31-4565-a3fb-2b5065f0ef60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:375519","sources":[{"id":"urn:uuid:4f76e7b8-3b7e-4641-9135-db1761b6b29a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q6PEY0"}
{"id":"9415732d-dd96-43b8-b115-992a455884cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:2f1fd054-f28e-4b0a-957d-9fc4ffd06b0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:P70604"}
{"id":"84afed93-26d7-4c4c-a1b8-9df7450eb622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44306087","predicate":"biolink:affects","object":"NCBIGene:4597","sources":[{"id":"urn:uuid:8021bfc1-0cce-4a9a-94d4-5efddec5fce4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7996","original_object":"UniProtKB:P53602"}
{"id":"8816a500-cde4-4104-b174-04da57ba31e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125616","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:401d5a9d-c08a-43c2-8667-5372790e9aaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8017","original_object":"UniProtKB:P49841"}
{"id":"b005b16b-8b3a-481f-8158-590cd0f51746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:f17f84d8-9865-4801-937a-d8b0f4c2a502","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:P56524"}
{"id":"6e386f09-871b-4422-860e-3415f509a767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126742266","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:6981cd38-5f65-4910-849c-97f9f90a6d1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13290","original_object":"UniProtKB:P13569"}
{"id":"6fe12e64-c374-4ec4-8d7d-15282353da9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1468","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:eac3cbeb-3c80-4de7-8961-d3dc141372e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1468","original_object":"UniProtKB:Q9GZQ4"}
{"id":"0eaf5319-f889-4d42-b48b-967bb3dd9fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I7Z38E70VF","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:0b86f239-9ac9-422d-8ce2-670991701c9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5817","original_object":"UniProtKB:Q62053"}
{"id":"40a9e931-b65a-49b5-8f01-b2890f3b85dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4283353","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:d6427495-5066-415e-840a-e51fdd979b98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10131","original_object":"UniProtKB:Q06418"}
{"id":"af8e8f79-4621-4d97-91c7-dba6efcf02ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13497","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:f6901023-0909-4c67-97ae-a3b56f68e267","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13497","original_object":"UniProtKB:P07333"}
{"id":"6c212571-3df5-43c4-badd-ba59bf29118b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311382","predicate":"biolink:affects","object":"NCBIGene:9088","sources":[{"id":"urn:uuid:ad1d9430-c68a-4b1e-9474-bb3e20dd6800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8183","original_object":"UniProtKB:Q99640"}
{"id":"e0e31b33-00b4-4945-88cf-3fb661d24e40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9NKZ9LYZ06","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:da71fd2e-fa91-40b3-b610-d20146b9f191","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9066","original_object":"UniProtKB:P16066"}
{"id":"99d8a7b0-a1e5-4789-a557-e9dae0db7b44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3697","predicate":"biolink:affects","object":"NCBIGene:8549","sources":[{"id":"urn:uuid:34d1f224-1582-4574-bd46-0b2098327d51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3697","original_object":"UniProtKB:O75473"}
{"id":"94e934ad-f34a-43dc-a9d2-a1b5c781ee84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57589985","predicate":"biolink:affects","object":"NCBIGene:8550","sources":[{"id":"urn:uuid:8a4cbbcf-7fc7-4687-84d5-d8bc1f324ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9848","original_object":"UniProtKB:Q8IW41"}
{"id":"fafcda6c-b6e9-43d9-9e3e-a55bd58f592e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:2382cfe9-bf6a-4886-96e0-6c5155f8ccf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:Q08881"}
{"id":"f336135f-9e15-45bf-8f8e-e744f26b40af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9817140","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:4a839cca-5dcb-4743-9e75-ca6616c98387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3102","original_object":"UniProtKB:Q02769"}
{"id":"53b258fc-6904-490c-ba7c-0344d94b0494","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:a32626f0-893d-4ee8-a7fa-0171514d667c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28221"}
{"id":"6ae9c0c0-773f-4b75-a469-69fb681af0d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94449","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:d9b035ae-388a-47d9-9be1-a915465b4041","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7459","original_object":"UniProtKB:P11229"}
{"id":"7f4725cc-3f26-4368-b915-eb444da7a6df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5B38CV1212","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:c7a791c1-7234-465f-9772-a19d9950a413","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7715","original_object":"UniProtKB:P28845"}
{"id":"a8bd2c2a-a14d-417c-b4a9-6652f9a665c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:697","predicate":"biolink:affects","object":"NCBIGene:84348","sources":[{"id":"urn:uuid:d775ad0d-78ec-42a2-8350-c50d055ddfad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:697","original_object":"UniProtKB:O89039"}
{"id":"a1bb4551-9322-45ae-b3a8-2dffdaeb9b13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92386","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:95e8becc-9a59-42a0-921d-9fc9f0f8e53f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:523","original_object":"UniProtKB:P08913"}
{"id":"1c498b06-7172-4d97-a49f-04fa7a74572c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11500","predicate":"biolink:affects","object":"UniProtKB:P59594","sources":[{"id":"urn:uuid:2360f25f-a59e-48d3-aeef-d217434d2db9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11500","original_object":"UniProtKB:P59594"}
{"id":"c7768588-afbc-4c2b-8736-b5e924f81735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5055","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:e778aaf6-caf7-4675-a055-844041151014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5055","original_object":"UniProtKB:P10721"}
{"id":"126d8e96-1965-49fb-a3cd-447584257d09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13792","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:5ca5224d-3bba-48f5-8aba-192f199069bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13792","original_object":"UniProtKB:Q15116"}
{"id":"2dfe4c76-6665-44f6-86e1-5f8742a3494e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135961","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:c6cdd1db-ada5-40e7-8f30-99c80fe37b9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5585","original_object":"UniProtKB:P30968"}
{"id":"6a93b654-4a8f-4a27-988e-d80353374e17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11700955","predicate":"biolink:affects","object":"NCBIGene:3817","sources":[{"id":"urn:uuid:b8a7f080-1a40-4e43-a8e3-3e8756a24a2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8672","original_object":"UniProtKB:P20151"}
{"id":"51dbeb7c-3a1b-4047-b4ff-b14ee556ca04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433294","predicate":"biolink:affects","object":"NCBIGene:4319","sources":[{"id":"urn:uuid:9ebbb547-a380-4f91-8b2d-61012f4bdc39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12669","original_object":"UniProtKB:P09238"}
{"id":"13d41cec-091c-4ba4-842c-e9d113fc5339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:de2af9b5-1f53-460d-b7de-7a07f200a86e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:O95835"}
{"id":"92322362-52d9-48e6-9226-18c3d84d099a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VYI79FLZ6W","predicate":"biolink:affects","object":"NCBIGene:9572","sources":[{"id":"urn:uuid:50198e0c-6dc6-44b5-8a15-cbbbb9394e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8900","original_object":"UniProtKB:P20393"}
{"id":"f3144184-01d1-45d7-aadf-b63d0fd6d6b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023860","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:563bfd88-874e-4156-9c81-92dc2526b1fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3189","original_object":"UniProtKB:O95749"}
{"id":"42d7365d-8a8b-4603-8f24-32faa652df45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91495","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:34cafb0c-47e0-46ab-bdf4-f338b2e525e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:325","original_object":"UniProtKB:P20309"}
{"id":"e3626e4b-5fd8-48f0-8881-c04cfab7a8b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16051023","predicate":"biolink:affects","object":"NCBIGene:4751","sources":[{"id":"urn:uuid:4b1f1af1-aa33-4de6-84a1-2dbe1c3b56e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8150","original_object":"UniProtKB:P51955"}
{"id":"cd2e3635-5fc6-48bc-bf50-4d8438aa4a31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813909","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:3bf9ff3c-a889-4f06-81bf-47a87bc11056","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10073","original_object":"UniProtKB:P53350"}
{"id":"7a4c0490-78d5-41f3-b104-a80a3fd7e116","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9139","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:58b0bf23-737e-41e1-beb2-c1cfd6d4b820","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4743","original_object":"UniProtKB:O76074"}
{"id":"1597ae38-b742-4295-8a03-a9ea2806e008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2315","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:d0ce4e22-480a-427c-81b3-26c8c3620fb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2315","original_object":"UniProtKB:Q92952"}
{"id":"9c8abe1b-e185-408e-bb21-3d8f46d0d2d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:6a9a33e1-31ef-4e27-9416-be9c177822f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:O14965"}
{"id":"8d030d68-f884-4476-beaa-e00b031567a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:40e92783-6778-4ddf-8411-3bde1d106d08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2645","original_object":"UniProtKB:P13631"}
{"id":"e1023187-8933-4db4-8c52-1f2c65b3fc73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28875","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:31c111de-3d53-4f7a-b4a1-34c539c14186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2806","original_object":"UniProtKB:Q5NUL3"}
{"id":"c95699ec-8b01-4963-a66f-353bb78544ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194548","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:17b1da48-3434-4f3f-ba0f-cf72f5a8079d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:509","original_object":"UniProtKB:P18089"}
{"id":"a2f48df2-bcaa-41dd-b698-7c989e222abf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53258570","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:5cfd21d1-e9dd-41f3-a05f-9b61ff37a808","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13951","original_object":"UniProtKB:P27487"}
{"id":"97b4c75b-511e-43b5-8a0d-c11cfaaf1290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J45910S3X","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:3200ccf5-c143-4a27-a835-d114e94de312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10314","original_object":"UniProtKB:Q16620"}
{"id":"7c016a0a-3171-48ff-b29d-5561218c81d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35420","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:06a10ce3-2c35-43ed-90d6-e874b60af10e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4290","original_object":"UniProtKB:P48167"}
{"id":"af6d4e99-0c1c-4c1c-b604-d53e3ef6ee9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4164","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:87a5074c-e7aa-46b7-a829-d8208cd9c2c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4164","original_object":"UniProtKB:P23415"}
{"id":"c042613a-28b2-4129-bace-217ebb2677b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6498","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:ab2a3aac-9170-45d7-a083-4e649e4192d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1034","original_object":"UniProtKB:P25090"}
{"id":"88e1ad4e-67a3-4245-9eae-a3c1579beb80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188723","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:fc97df5b-01b5-4922-a68d-8a6fd2b80b3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:568","original_object":"UniProtKB:P13945"}
{"id":"d93507be-4db0-465b-a09e-be43e8798cf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56649447","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:195abfb2-2a6c-4693-bbdd-17d60ea7450c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12209","original_object":"UniProtKB:O14684"}
{"id":"44a40e9b-fc94-452b-8071-9954c19bbbae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:c001544f-fc06-4819-94fc-7d9b671be8ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4193","original_object":"UniProtKB:P34903"}
{"id":"ee1f99f9-5fed-4a09-bead-627a48e8e01f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46239428","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:245cf9fc-ea96-4258-aefc-79ba781e6166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8757","original_object":"UniProtKB:Q9Y233"}
{"id":"e44c5e9a-49b8-4322-93fa-d93de7a45915","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:3739c5af-15d1-43de-bbd6-890915b6a5a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P31388"}
{"id":"b881d975-bd22-43c5-9605-4ba26a8a42b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8O74K609HN","predicate":"biolink:affects","object":"NCBIGene:1071","sources":[{"id":"urn:uuid:a61a565b-0597-45af-97a8-0d40b65ff39d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12205","original_object":"UniProtKB:P11597"}
{"id":"96cd80fd-16d0-40aa-b1f5-7f21693e2cca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3984","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:8b84edd3-b7db-4064-9ac7-1cb1712af50b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3984","original_object":"UniProtKB:P02708"}
{"id":"b95533bf-d387-45bb-bd61-31f7fa225b4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91972027","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:a41a92df-ed75-428d-aa19-2da79cd53e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10030","original_object":"UniProtKB:P37231"}
{"id":"13d39a4c-ad5b-4386-963c-d6be303284d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121918","predicate":"biolink:affects","object":"NCBIGene:24408","sources":[{"id":"urn:uuid:a528f5dc-420c-4fbc-9eb3-fd7f0cdd0bcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4239","original_object":"UniProtKB:P35439"}
{"id":"3edd1d5d-18ae-4f6d-8842-a2cdcf6ee52e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162623670","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:f6c6fe83-4958-4760-8add-0e626284a8fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12710","original_object":"UniProtKB:P00533"}
{"id":"e16fccb7-995f-4406-8afc-37deab648767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94813","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:01e2985d-146d-4767-ba95-7d6517afba35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3441","original_object":"UniProtKB:Q03181"}
{"id":"0f0f0abd-40ff-47b7-b877-5f4dd8574418","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44222958","predicate":"biolink:affects","object":"NCBIGene:1456","sources":[{"id":"urn:uuid:67a311bf-3dd4-43eb-91aa-b463c0fd20d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8214","original_object":"UniProtKB:Q9Y6M4"}
{"id":"303d0786-2ecf-4418-b6c1-9cb327ab0c4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:99eb5068-375c-46fd-b4f3-c5781ac80a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:Q13546"}
{"id":"acc8c5dd-6878-4052-a52d-3208d333ee38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:51128761-d93c-42da-baa1-ca8220b2ff91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P25099"}
{"id":"23596b1d-71a0-4b08-a9fb-07a0213cd563","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60325","predicate":"biolink:affects","object":"NCBIGene:166614","sources":[{"id":"urn:uuid:593ce40f-aa25-409b-b501-95cb1605b0a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8057","original_object":"UniProtKB:Q8N568"}
{"id":"b1345013-d2eb-4d34-9353-dce9ba602abe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2231","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:c4dd53ed-c823-4c36-991d-3dc8e6d3d6fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2231","original_object":"UniProtKB:Q00788"}
{"id":"bc2812c6-9910-487d-aa9e-7d4c2a880f09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:d8819c3c-6610-4598-9400-8a83c2bd6317","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q8WUI4"}
{"id":"8115135f-998e-4259-97ca-decdf206bcff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192545","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:8a8e272a-33fd-40f9-a766-c1f08cf21db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1394","original_object":"UniProtKB:O15303"}
{"id":"aac2cdab-fd73-47bd-b992-89ed83f0fc4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566612","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:0395c6a6-a1a2-4b16-b540-810653b94106","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8172","original_object":"UniProtKB:P06239"}
{"id":"3aad6d0f-443b-4af3-b078-5c2f7a74cf98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:bd50bf09-ed63-49f9-b048-da31c5850326","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P21817"}
{"id":"849eef69-e7cf-4683-87ea-69d6ea6148f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90668081","predicate":"biolink:affects","object":"NCBIGene:8476","sources":[{"id":"urn:uuid:710e4875-1298-4f5e-8c5f-58e28c03eb95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8197","original_object":"UniProtKB:Q5VT25"}
{"id":"6b5df957-0028-4a45-9f35-9d1cb39f6d63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5O1LL04GJ3","predicate":"biolink:affects","object":"NCBIGene:610","sources":[{"id":"urn:uuid:2ec79c00-5711-410a-ab22-f1254de3dff2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2355","original_object":"UniProtKB:Q9UL51"}
{"id":"9254e4f5-9131-490e-9dc2-0ba4e52ad062","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37850","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:1145de01-b0ec-41d0-8df3-76f0c9afe180","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2459","original_object":"UniProtKB:Q14643"}
{"id":"9513ccfb-b8c7-4cb5-92aa-9f3ea35e580a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42645487","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:6baac46d-e788-47ca-a04a-648947f944fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6232","original_object":"UniProtKB:Q14833"}
{"id":"e45a585e-11b5-4fb8-9a1c-d66cb99fed7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3238952","predicate":"biolink:affects","object":"NCBIGene:10434","sources":[{"id":"urn:uuid:03acccca-ce4a-4e2e-b105-dbaa4f8b47c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13412","original_object":"UniProtKB:O75608"}
{"id":"1f3fed27-415b-427e-b7a0-8deb0db93f3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:635","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:1581fc5e-a19a-4486-8df7-b2bd5e2c44c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:635","original_object":"UniProtKB:P30550"}
{"id":"b238719c-7f2d-4b8a-aab4-685daf1f5e14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2614","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:315a423c-b986-44f1-b251-e452aacb0036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2614","original_object":"UniProtKB:Q14524"}
{"id":"22ccd327-3d8f-4785-b6ad-4a7cdb9045b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5002","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:1b9f122f-b922-45ef-a225-7a8e54e7e8bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:939","original_object":"UniProtKB:P21917"}
{"id":"4a7e82a5-1e01-4efe-b2f2-8563acfb2209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5L854240DQ","predicate":"biolink:affects","object":"NCBIGene:64840","sources":[{"id":"urn:uuid:6ecbb0ad-e0ca-49d1-bfd4-581f0efb1c26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11168","original_object":"UniProtKB:Q9H237"}
{"id":"b0e8a7c5-796b-47cf-b06a-b1e2bac14e2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:70f7db60-d6ad-4337-9b0a-b4130762c3a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P48542"}
{"id":"c2d4b8cb-ffe3-43f4-aff2-aec5230ddd07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46861530","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:1fb09652-c1b4-4114-8017-a59861be9b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11657","original_object":"UniProtKB:P0C6U8"}
{"id":"3db35ecc-549c-4fe4-a6cc-86c12be9209d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8876","predicate":"biolink:affects","object":"NCBIGene:2186","sources":[{"id":"urn:uuid:4d5469a5-a081-4517-a9d3-ca51347af1b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8876","original_object":"UniProtKB:Q12830"}
{"id":"2d70ae83-42b6-4407-b6fc-0c7385cd64ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3752","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:662c86a5-c450-4aee-ae60-09031f1b7171","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4159","original_object":"UniProtKB:P03372"}
{"id":"3c82efde-ca7d-4aae-8563-b94fba50dbfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:874cbb2f-341a-40f0-8760-376c32ad85d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P19020"}
{"id":"47f32c3d-e35e-488c-a600-f492c8856bb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:dd136b4d-6ced-4991-9077-785692c0fc3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q16445"}
{"id":"eac6b4b1-29f0-41d1-9267-8324652c121b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125340","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:fa82a3db-186b-46eb-9630-2343bc0a2e0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8061","original_object":"UniProtKB:Q9UQB9"}
{"id":"a310a942-ddc6-432a-bd7b-7758de750a27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2198","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:68f3cac6-025a-471b-b3cd-858f168b50c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1347","original_object":"UniProtKB:P48039"}
{"id":"1ba136e8-bfe7-49f3-83b1-24c709f589f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:33639WNC7Q","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:668b7b44-17e9-4c5c-9244-f2fd9a032a9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8793","original_object":"UniProtKB:O00329"}
{"id":"4841f26c-9a1e-4617-8855-35a808cce073","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71446540","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:b40e5019-3360-4039-a93b-d7f952b66809","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:842","original_object":"UniProtKB:P49682"}
{"id":"d26ac40c-3f6e-483a-ae4e-242ef58b3633","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993655","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:e8f4bce2-1c31-4b80-8525-2855d426141f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12569","original_object":"UniProtKB:P21453"}
{"id":"736bf0b7-153e-4d00-aa90-d477f2f0548b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91453","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:f921bd40-124e-4c25-b53b-fe652d0aa54d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5996","original_object":"UniProtKB:P45984"}
{"id":"40ddd7bb-1d89-4115-9403-edbd7ce9e102","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:cc2f6609-f4dc-4a8d-aaa9-5b53a99f1ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P23944"}
{"id":"16f5df54-b2c4-4f01-89e2-9272d188c645","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:72a7054a-b2be-4b2f-8b16-0c40039cdb4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P32240"}
{"id":"be8fe823-8fc8-4d61-9010-d9dc4ae2cab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5L3SX16QBQ","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:47f12e5c-87d7-4a3b-a058-38be347fd0c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9254","original_object":"UniProtKB:Q9NYK1"}
{"id":"cd0ba568-c8ba-4a2f-9939-fd344dba9bba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134726","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:54626e67-0733-494e-99ab-c2747340c200","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5608","original_object":"UniProtKB:P0DMS8"}
{"id":"032f8e59-9655-43c3-8764-2ac1c8b6ca27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5847","predicate":"biolink:affects","object":"NCBIGene:22171","sources":[{"id":"urn:uuid:8ffafffd-1634-45ef-8867-732a4d490dfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7403","original_object":"UniProtKB:P07607"}
{"id":"99986687-64df-49d7-af13-ff6ed0b747d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232354","predicate":"biolink:affects","object":"NCBIGene:25874","sources":[{"id":"urn:uuid:75b45c99-d05f-490a-ba4f-b8b488038cf9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11302","original_object":"UniProtKB:O95563"}
{"id":"3fbc5b94-94ae-4521-96a1-e03755f96002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:55285412","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:77bc17e1-3631-42c1-b095-2ea005f54339","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4143","original_object":"UniProtKB:P24046"}
{"id":"a5aa7175-77b5-4443-8e08-88f20a6e7290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:641990a5-dd3c-4136-a64a-7eb9acb241c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P31388"}
{"id":"7163631f-2a5b-4b87-9a79-186fd3f51bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:4688ba2c-fe6e-4c45-8a38-a1a01077639d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:P11802"}
{"id":"270b7492-85d9-4182-9ed9-53d71d06bdd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3603","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:60330d39-be5a-4058-87cc-d12e0e87809b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:308","original_object":"UniProtKB:P08172"}
{"id":"8e3a5bd6-03f1-4d34-8451-1b4fb765a27d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:789Q85GA8P","predicate":"biolink:affects","object":"NCBIGene:3418","sources":[{"id":"urn:uuid:abef0c96-3d5a-4d35-9c4b-852d7cda4b64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10663","original_object":"UniProtKB:P48735"}
{"id":"a43eee64-9e8d-4d92-9d72-874eb7a2cfc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:57369","sources":[{"id":"urn:uuid:0491c220-215d-478a-881d-981e66a38502","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q9UKL4"}
{"id":"1cde2950-4fc7-4639-b2e6-5e121b6ca1b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27958","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:cff6a2b4-b085-450b-a788-0ab694cebf15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2286","original_object":"UniProtKB:P46098"}
{"id":"ab6f02ec-ab07-4251-9554-36b783747f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129665","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:1b4d7758-d8ca-441b-98e5-dcff4531fa4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1155","original_object":"UniProtKB:P32241"}
{"id":"753e4f39-9b5c-427c-8ea2-70212ecf686b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:eb837b12-5347-4589-ad7f-1bdd820697cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P30543"}
{"id":"b9504602-bc4b-4b15-b5e7-a6aabf09b104","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50186","predicate":"biolink:affects","object":"NCBIGene:367315","sources":[{"id":"urn:uuid:36194bb9-3d31-46ce-9219-2d03420fc32f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2920","original_object":"UniProtKB:Q33BM1"}
{"id":"903a1c4d-c789-4d20-8083-b1ba605402c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6916","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:c08fd186-7d82-435c-9529-c5fd33d85f27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2629","original_object":"UniProtKB:P35499"}
{"id":"65da11d4-4901-402f-ad5b-db166787ebf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156907317","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:8de33381-dd3f-4355-9744-feb3997ff1bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11765","original_object":"UniProtKB:P0DTC1"}
{"id":"fb78954e-92d9-4575-988b-4f7621b3abb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91338","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:5985d626-037d-44e9-a814-820dcd2586da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5714","original_object":"UniProtKB:Q9UM73"}
{"id":"decfa8e1-583a-45de-b0c2-bdbf1c513a92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6660","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:3e3fb826-90da-43dd-9448-4fe2bab871bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6660","original_object":"UniProtKB:P55085"}
{"id":"cb938875-6424-43da-8af6-131abfb91450","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:864492","predicate":"biolink:affects","object":"NCBIGene:25111","sources":[{"id":"urn:uuid:994e47e0-0820-4c22-9126-8dc173d95a0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3263","original_object":"UniProtKB:P08485"}
{"id":"fa9a8930-7316-43b4-ac09-b988630ba4b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91407","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:0bb5d74a-2e82-45e0-9461-212d2c1dfcbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7791","original_object":"UniProtKB:Q04771"}
{"id":"8d473a63-7a72-43c6-8ba0-91cd026de10a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1IJV77EI07","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:50132ed0-fab1-473d-b69b-c1c6279b2cd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8293","original_object":"UniProtKB:P08581"}
{"id":"46c343b7-7523-4716-a795-bbb214bbb551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:c5fb49b3-ae9f-44d7-9991-d7d910f21b7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q8NER1"}
{"id":"797b7046-b253-4c5f-96cb-b830e386a26b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6954","predicate":"biolink:affects","object":"NCBIGene:1583","sources":[{"id":"urn:uuid:fee58d0a-2b4d-4ea0-9ae3-64495615c4c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6957","original_object":"UniProtKB:P05108"}
{"id":"013418fe-b056-4ff9-9cfa-91d8e3698998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5296","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:051da09f-f768-498c-ae5e-b7ae7a7eaf22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3439","original_object":"UniProtKB:Q07869"}
{"id":"45d0b5ab-5af8-4c79-8130-17df4e1ab5c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64131","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:fcc3be40-589e-4dcb-bd02-b15e35041931","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:73","original_object":"UniProtKB:P35348"}
{"id":"a81b58a6-7953-40da-9a8c-fe6f5ffa18d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88307","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:685f0807-a3d7-4b5e-b116-271aebf7fb7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:891","original_object":"UniProtKB:P32239"}
{"id":"a531771f-5962-46a5-a970-e6c6eabc032a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11490","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:7a2978aa-ea61-42be-914c-4757e16a9f46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11490","original_object":"UniProtKB:Q9GZQ4"}
{"id":"2210c301-5b98-40e9-835f-b06c5fd17d99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9870500","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d194c196-eea2-4895-bae3-84ab7814237a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:75","original_object":"UniProtKB:P08908"}
{"id":"b7beb3b3-51fc-40fe-be50-42fc37e1e9fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3658","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:c5a8ac2c-ddad-4235-85ed-9105c0717358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3658","original_object":"UniProtKB:P25025"}
{"id":"a14bcb9b-06a4-49ba-abd0-38eb14b4ab19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18392356","predicate":"biolink:affects","object":"NCBIGene:5653","sources":[{"id":"urn:uuid:4b342bee-a186-4ba6-b428-d25e81b9d89e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8655","original_object":"UniProtKB:Q92876"}
{"id":"b8598764-e904-4137-97f7-721941de44be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69832","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:e541b2a2-cbf6-4f84-b951-be6fc1e5474f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10302","original_object":"UniProtKB:Q8NET8"}
{"id":"6246b4e3-27af-40c2-b619-63b395dcadaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324620","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:ddbd8e07-d0f0-43e8-9377-14f221f78007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:262","original_object":"UniProtKB:P34969"}
{"id":"974b819d-cd31-4235-abe9-9ba3a9982221","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5276503","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:f73124ed-e345-49fb-b13c-7a99b2b33ed6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3198","original_object":"UniProtKB:O95749"}
{"id":"1222cd88-1051-4d5a-8173-4003c79b93ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:170123","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:a8bbb25f-bbf2-4099-82d7-a0877a2cc1e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2936","original_object":"UniProtKB:Q9HC97"}
{"id":"fcfb909a-31a9-454b-b86d-3440e8f29bb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3857","predicate":"biolink:affects","object":"NCBIGene:2692","sources":[{"id":"urn:uuid:1f5510bb-ad44-4995-9252-1f55b66d1a80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3857","original_object":"UniProtKB:Q02643"}
{"id":"a3dbeb49-c49e-46cf-9e39-bd3e0100c571","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2618","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:18aa68a7-5049-4a81-85f0-c3f498c2c41e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4128","original_object":"UniProtKB:Q12879"}
{"id":"f6785c70-0a3f-42bd-87d2-7df182a4e47c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34541","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:db3eefbc-4af4-49df-940a-b63089822ddb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4138","original_object":"UniProtKB:P42263"}
{"id":"a2a9345b-a4cd-4332-827c-32f8ef603b55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7936","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:3a0dcffc-ab90-489c-be51-4685f764fea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4790","original_object":"UniProtKB:Q99571"}
{"id":"a124938b-08da-4644-948a-b4ab54909ffc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:55361","sources":[{"id":"urn:uuid:d08b3d07-57d1-49c5-99f4-aa106c90e5bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:Q9BTU6"}
{"id":"8f02b214-d29c-4c92-9fe5-5a5270035392","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:55879","sources":[{"id":"urn:uuid:525fb63b-0a06-4b16-bc3c-e0007000fcc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:Q9UN88"}
{"id":"0f57a205-cc3a-4686-85bf-4e32ee27d71a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44182398","predicate":"biolink:affects","object":"NCBIGene:6446","sources":[{"id":"urn:uuid:f3eac562-12eb-4ce4-82b6-a145739a71b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9407","original_object":"UniProtKB:O00141"}
{"id":"627dc8ce-ff4f-49e6-84b3-87f6d665375f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93363","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:626385ff-96c7-4d19-931c-538341026b27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5509","original_object":"UniProtKB:P08913"}
{"id":"2fd1941e-0dfa-4df3-8239-a87a280ce99a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YUN2306954","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:3e3e8322-6c3c-41b6-9f3a-747dbe8662d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10644","original_object":"UniProtKB:Q96RI1"}
{"id":"8c9e0c4a-fbe4-4a10-84a0-dfba157d4e55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UXV32MJ2CA","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:1feb3fe8-4709-44d9-819c-3b0a0f526f0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4111","original_object":"UniProtKB:Q8K424"}
{"id":"f1e76017-655a-4880-a5de-23f20ba23054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16197316","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:8cde5fcc-cf84-4a1c-9e0f-e5cdd17a84cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:854","original_object":"UniProtKB:P61073"}
{"id":"cf1152f2-d3d4-46b5-9a6a-89189abaae90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:e2cf2805-38b1-455e-87df-d39c0add6adb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P28223"}
{"id":"6107ccab-aa4f-43b7-a598-03368002f27b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:29718","sources":[{"id":"urn:uuid:7b70e641-fe7f-454b-854c-dee2ca3fb661","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:P49655"}
{"id":"aa278e4a-74b6-4bc7-a31c-770d63112783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4670","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:a1e1e9bf-e5ec-4228-9f22-1ba1c76c6ccc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:535","original_object":"UniProtKB:P08588"}
{"id":"45d739bd-1006-4262-bcce-192ba414ecca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:8dfb122a-1cbc-49ee-bffd-53580334ecda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P0DMS8"}
{"id":"ee003e80-5104-4032-a654-c653de80e7fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4638","predicate":"biolink:affects","object":"NCBIGene:50838","sources":[{"id":"urn:uuid:4173c8fc-3447-4489-9181-1eff996b115f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7163","original_object":"UniProtKB:Q9NYV9"}
{"id":"d81b2179-c4b5-47ec-974a-22a4e4100353","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130451","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:6a04ca7c-0966-4f25-a475-271a69b37588","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:606","original_object":"UniProtKB:P35414"}
{"id":"570437c8-eb5e-42b7-b4eb-b98ad1e8406f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:23f7a84e-29e9-443f-8190-278920d140cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:P24941"}
{"id":"0a4664ac-e6ab-4303-a1e0-c4d9be475901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2383","predicate":"biolink:affects","object":"NCBIGene:50599","sources":[{"id":"urn:uuid:90c2e60e-7479-420e-b901-98a13ad0bd7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2383","original_object":"UniProtKB:P63251"}
{"id":"d45cc06c-15d5-4ef0-8d8d-04ce350a1bb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64187","predicate":"biolink:affects","object":"UniProtKB:P35520","sources":[{"id":"urn:uuid:5dfe22aa-ccc6-4ffa-8b75-94ff146e90ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5150","original_object":"UniProtKB:P35520"}
{"id":"de3439fc-c011-4fa6-a1e9-43c345ad8fb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B1MW2ME77A","predicate":"biolink:affects","object":"NCBIGene:25976","sources":[{"id":"urn:uuid:f3d84a3c-9e29-46fe-9d64-0cf7eab3a54e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13118","original_object":"UniProtKB:Q7Z3E1"}
{"id":"aa32101b-8f43-4fcd-995d-5f5d79e36c66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90197","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:7638fcf2-fcff-4701-a475-1142e58cdc28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5700","original_object":"UniProtKB:P08581"}
{"id":"5a296ab8-e39b-4478-86c1-7008ff55bf01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1999","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:4ba39d3b-8553-4ba0-91f6-d3d6a5968ef5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1999","original_object":"UniProtKB:Q9NSD7"}
{"id":"fdc7ec75-6641-4915-883c-022a1bd13854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91467","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:ee6f82fa-df69-4303-aa94-5d2b52fc73d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9912","original_object":"UniProtKB:P00533"}
{"id":"1c9d3b45-2fe5-4371-b87d-4bf37b162e1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137749","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:4f789a2c-9dac-49e9-a243-945e6701f6d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6171","original_object":"UniProtKB:Q8TDS5"}
{"id":"194059ec-402c-4d8e-983d-e08a3891831c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9599","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:da7d4062-dd1e-4152-9995-94f840df8fff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:565","original_object":"UniProtKB:P07550"}
{"id":"f24a2d84-1805-4b52-a91b-415de4751454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:f1dbbb4c-aef5-42e9-8109-84eb0d1bf428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P15388"}
{"id":"77ec3671-533f-40fc-8150-943d21b950ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131169","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:1779dcfa-2193-4792-b474-cb8f6e2cb51f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7795","original_object":"UniProtKB:P48736"}
{"id":"b905d09b-e990-4719-9aa2-0471e401af2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34848","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:e9bb6b59-a52e-4807-83e0-9ace45633fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3031","original_object":"UniProtKB:P04035"}
{"id":"b0af9a3c-3146-4391-9ed5-6f942241e025","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91353","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:c6fdbf80-fb3e-41b9-bf0d-5d6f6bc85db6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5676","original_object":"UniProtKB:Q02750"}
{"id":"a05dc636-a379-4f96-bcd6-eb352741630e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230483","predicate":"biolink:affects","object":"NCBIGene:55170","sources":[{"id":"urn:uuid:448495b6-d41e-4a2d-b873-1780aa59c9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8955","original_object":"UniProtKB:Q96LA8"}
{"id":"07cd5ed8-53c1-4b75-9777-60c16ebb060b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44191096","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:835bd1a8-494c-49b3-9266-3452497315e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3956","original_object":"UniProtKB:Q14833"}
{"id":"80f23735-b58e-4f3b-b67b-dd25f1b610a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:82d16841-49c4-4e77-86fa-c0c85153cde5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P23416"}
{"id":"497b3bcf-c112-4ab4-b95f-32d41c4117af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X3TDA066ME","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:c8482fc8-6ed5-41eb-84b8-58c11e6c5a84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3497","original_object":"UniProtKB:P32246"}
{"id":"23c86a28-557d-42d9-b8b5-36714ed106a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93239","predicate":"biolink:affects","object":"NCBIGene:54583","sources":[{"id":"urn:uuid:a658d767-a567-4c38-a507-89d9dd3c7734","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8230","original_object":"UniProtKB:Q9GZT9"}
{"id":"3be6fd30-541e-4edd-b2e1-8dc42fbb2c82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164753116","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:9bef3ad7-aaaa-4220-abfa-4466ec308ffe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13320","original_object":"UniProtKB:O14744"}
{"id":"9e3d17ce-9b99-4333-aaf7-559a80fa3a3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13045","predicate":"biolink:affects","object":"NCBIGene:7293","sources":[{"id":"urn:uuid:27b4f846-dc9d-4cdb-a8ef-d9a6f1236fbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13045","original_object":"UniProtKB:P43489"}
{"id":"0f80677c-0254-42c8-805d-cf08d9d13ec2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:375519","sources":[{"id":"urn:uuid:ecfdeab0-7654-473c-8b7b-125cf5893268","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q6PEY0"}
{"id":"e286466a-ff7d-4b1c-8cbc-8f97478e4bfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3293","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:f5d30771-d391-4d01-9274-439bd876b751","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3293","original_object":"UniProtKB:P35000"}
{"id":"08425fab-f515-425b-b3d1-4c09a4357e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:8e2d2ffb-29ad-43ca-9041-f7a3970f3daa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P11362"}
{"id":"b36c259f-2d5b-4376-8c3e-684ccd45ae4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:94226","sources":[{"id":"urn:uuid:e46da450-86b5-44b8-8a50-a7749868e090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:Q91X56"}
{"id":"0ae3087f-3d45-45c2-a9a2-ac5fa0826472","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3219","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:cb84a01a-4ce0-49a1-a14e-e26b3d86bbc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7135","original_object":"UniProtKB:P23975"}
{"id":"98918738-3ebc-4827-9622-56c5df2356c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93007","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:ea4772be-caa2-4e1a-996f-620902cb1acd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6678","original_object":"UniProtKB:Q99720"}
{"id":"4efcbc18-41d3-4b4a-bc88-2e827b98112c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8762XZS5ZF","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:c361e2f6-362d-41d2-a399-f4e68a539c8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8958","original_object":"UniProtKB:P00533"}
{"id":"6d81f156-a9ca-4bfc-91e1-16f5524aa230","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL188906","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:3953fc92-f172-4664-8677-0b7993fef735","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7442","original_object":"UniProtKB:P23385"}
{"id":"488c09d0-fc72-4943-8951-b6752abd6509","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11641563","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:2d6e6461-1829-4a19-8abb-561e0ee26ed5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7823","original_object":"UniProtKB:P39900"}
{"id":"21691f7a-7676-4317-806d-74ddf5b309db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9CXQ3PF69U","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:5dc7142f-c4e9-49c7-adc5-6e2a6f2f046c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12896","original_object":"UniProtKB:P03372"}
{"id":"197df420-54ee-4264-ac37-583ab4595116","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:6ee07f05-3826-49c3-9e1d-eb59bd33e9ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P29276"}
{"id":"787f7c25-b6d0-4eae-a36b-fbadd2cd4acf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8294","predicate":"biolink:affects","object":"NCBIGene:1675","sources":[{"id":"urn:uuid:5428721b-9ff2-4322-afaa-885aa69ca2c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8294","original_object":"UniProtKB:P00746"}
{"id":"2bda8caa-e6cc-4ca1-bbeb-f7fcc115956f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3654","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:ff79e9b7-7d02-4819-9fc5-e802aa832378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7147","original_object":"UniProtKB:O43570"}
{"id":"2081cd11-8d6b-4af1-9082-fb7b8b977b00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9241","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:7163d05e-d25e-425e-885e-a7ac6b3c1e82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2875","original_object":"UniProtKB:P08235"}
{"id":"5276915c-3414-448e-b930-bb0710c206e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:119486","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:cd42bbfe-5911-4040-a887-586eb3b972ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11287","original_object":"UniProtKB:P08684"}
{"id":"027c5ebc-c987-4b75-9eeb-78cb2d65efa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10282265","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:b917c463-15db-455c-9350-c4d5901cceb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13071","original_object":"UniProtKB:P49682"}
{"id":"31ee7f34-a638-4081-a89c-de257126e2cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15632","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:6f674216-ab7e-44b0-8fd2-d38aace75ae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2483","original_object":"UniProtKB:Q8TDS5"}
{"id":"07f4d41a-6e0b-4892-a9f2-67ec0fb058ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:a9795701-7506-43b8-886f-11edbef014b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P32305"}
{"id":"a0387635-1bad-440e-8ed3-8aebd194f9a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817481","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:29186879-9a2c-48fd-afec-1eaa75fdfa23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6092","original_object":"UniProtKB:P47211"}
{"id":"bcd4079b-8458-4967-b555-84b0fb2dd7f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136254272","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:74dbf898-6ff0-43a8-ac70-26cc4e1c6969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8171","original_object":"UniProtKB:P49841"}
{"id":"cdd8a32f-2cb5-4329-a7a6-74a59b05e605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91666633","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:c55820e0-f2bb-4f96-bd5e-2e3b240fb357","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10003","original_object":"UniProtKB:Q99250"}
{"id":"c5b27b3b-7c73-4035-9c4b-dd17aa791008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73420","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:d41afa05-f0aa-44e4-9557-71aea648e2cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2924","original_object":"UniProtKB:Q99500"}
{"id":"5bf4d769-7897-4432-be17-a2d5c89ef03a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9JH486CZ13","predicate":"biolink:affects","object":"NCBIGene:112398","sources":[{"id":"urn:uuid:bd329051-937d-45bd-8da1-1e03aabd1a19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8456","original_object":"UniProtKB:Q96KS0"}
{"id":"7ffd468d-cca5-46cc-8d48-ba8783db5522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8083","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:fee8392f-af48-45a9-b2f4-fbe52381a3a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12455","original_object":"UniProtKB:Q9NYV7"}
{"id":"085097f6-47ed-4f85-b81e-a28826ce9916","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3048","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:ee118bd8-7574-481d-bd14-fac9900b60ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7601","original_object":"UniProtKB:P10980"}
{"id":"ae7f33ba-0b82-432d-ad1c-e389600b4e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3112","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:0745e0d6-c896-4a59-9595-92a83329d9b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7128","original_object":"UniProtKB:P20309"}
{"id":"115e1f88-44ec-46cb-b0f6-70a6e24ac7c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155818902","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:ea9d81f9-c41c-4b7f-a5a5-64e797b4af43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11701","original_object":"UniProtKB:P43235"}
{"id":"cfe8c6cf-ce81-4073-b338-80c0d8e89dc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188811","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:a4fbe1c3-c8e2-421b-8201-d5a0a342ffd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13399","original_object":"UniProtKB:Q16769"}
{"id":"12e58753-1bdd-419f-a3b6-a26a37e2cb8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:423115","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:7f354ed3-c26a-4e1d-b585-22b913ad464a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11238","original_object":"UniProtKB:Q9HBA0"}
{"id":"59cd8a43-7720-45e0-bbca-1ce21ddf6a48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q8L6AN59YY","predicate":"biolink:affects","object":"NCBIGene:9152","sources":[{"id":"urn:uuid:b78c7861-7642-42ce-926d-2d86eccbf8ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7546","original_object":"UniProtKB:Q9Y345"}
{"id":"489d86f1-081b-45c4-8718-726946cc82a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121918","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:77f6fe28-ade6-405c-8d07-728b4d3b4bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4239","original_object":"UniProtKB:Q12879"}
{"id":"c3f3fea6-962c-4a83-8260-1bdf2a933778","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197437","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:979bcbb2-097e-4b56-a5c2-ad827fe304d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7008","original_object":"UniProtKB:Q13547"}
{"id":"87bbed28-7322-4eee-abe5-130a5be4ada1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73339","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:e4f6105c-bcd5-4d6d-aa83-b2ee744e967f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:327","original_object":"UniProtKB:P11229"}
{"id":"e36ca29a-1ee4-4860-9024-10f83d889a4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13113","predicate":"biolink:affects","object":"NCBIGene:13850","sources":[{"id":"urn:uuid:ff0425e3-a13f-445f-8774-bd802e8504ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13113","original_object":"UniProtKB:P34914"}
{"id":"f83f1347-7519-4003-ac8b-64372a7bdcd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:65198","sources":[{"id":"urn:uuid:18eb7fc7-9bc1-4bb9-ba8f-3371106c1202","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2351","original_object":"UniProtKB:Q63472"}
{"id":"08fe1eed-72a2-4c84-9138-21cd18ac8423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91448","predicate":"biolink:affects","object":"NCBIGene:1452","sources":[{"id":"urn:uuid:18fefd02-43cb-4e2b-8930-a3d89928d69f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5940","original_object":"UniProtKB:P48729"}
{"id":"69cb0f1e-653d-4259-b949-730c0b80283e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:193183","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:ea1c0027-0fbf-448a-a502-b75d6714e843","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4354","original_object":"UniProtKB:P32249"}
{"id":"1eae1460-6214-4d01-9d4d-f5b5903436ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:51393","sources":[{"id":"urn:uuid:f441ff87-3dbe-4bad-9df3-26ce52601967","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9Y5S1"}
{"id":"a1341392-4cac-42d5-93a7-a51b4c8c1e6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:01J7526K2Q","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:73de4b62-99d3-4274-9aa2-0a14d8267fa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9569","original_object":"UniProtKB:P21453"}
{"id":"b60a3cb9-e014-42e1-9abb-93546e976fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145867030","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:b01231ac-8a6e-42b6-905b-593b68b49969","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12220","original_object":"UniProtKB:Q16581"}
{"id":"6626ecdb-60bb-4818-bec8-7b9e85608562","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101085","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:8588e0f4-fb43-4ad7-b70c-33c2cfc8e755","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6807","original_object":"UniProtKB:P22748"}
{"id":"ac3e8152-9803-4c00-b4ea-fba25babee45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:234669","predicate":"biolink:affects","object":"NCBIGene:340024","sources":[{"id":"urn:uuid:81a5ee91-5d50-43af-b095-fc0483d6471e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11228","original_object":"UniProtKB:Q695T7"}
{"id":"a0282337-629e-40ee-bbde-08f913d0cbad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231618","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:ee597b2e-ec87-46a2-8381-3d94fee75190","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2817","original_object":"UniProtKB:P03372"}
{"id":"cce21f80-a495-4ea2-8a2c-c9c48f6fc133","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:76856","sources":[{"id":"urn:uuid:61c13cb2-df7a-4aec-935a-97f959f2ff5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q80W99"}
{"id":"8bf7bd4f-c156-4265-a92f-978f70ec9728","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553159","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:8117d5c3-e222-454c-a562-07f0eb567eb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10218","original_object":"UniProtKB:Q9NYA1"}
{"id":"d81243bc-6ac0-4dea-92a2-af7cf2534258","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122585078","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:b53344ae-45e0-4ad0-86cf-3d62d3685750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10889","original_object":"UniProtKB:Q9NR97"}
{"id":"ea756c25-f2e6-495b-8879-177906cabb08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:1dcb27b8-db86-416a-99cb-0469f556d595","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8593","original_object":"UniProtKB:P08172"}
{"id":"c8699668-e118-4c3b-bcd0-869271ddb2e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53187671","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:6c399e82-08b4-4004-8087-6e94e47de351","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12213","original_object":"UniProtKB:P04629"}
{"id":"2827a782-49a6-4790-8a73-85d237224d14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1M7NI1A92L","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:7ddc9da4-c6a9-483a-880a-a25144d4521a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4095","original_object":"UniProtKB:P34903"}
{"id":"05cb8fa7-4a27-43b0-90fe-c5ae6625f80e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452040","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:b355f57f-7d09-46d1-bbd9-fbc236b4b195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9190","original_object":"UniProtKB:P35462"}
{"id":"fd75cfc7-d601-434f-8110-3cd793f4d9b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91972027","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:ce486fa5-3518-47e7-b1bc-a630f9722560","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10030","original_object":"UniProtKB:P34972"}
{"id":"47e363d3-23cc-4970-998d-6617590b6645","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:5d0363c1-7956-4c95-a09e-7926fe6b9d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:P08581"}
{"id":"70320f4b-e467-4a49-8d51-7e355012d2e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553169","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:eb003b99-0bda-4aad-9c24-d4bce32a30ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10297","original_object":"UniProtKB:Q9HCF6"}
{"id":"d640bcb0-8645-47cb-9e85-69f93e86ce17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91658","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:29d9d388-effb-4b8c-9688-e1fa6b8d662e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9750","original_object":"UniProtKB:P14902"}
{"id":"0ccce8bf-bf1a-44d8-81a3-93408b8ac9e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801156","predicate":"biolink:affects","object":"NCBIGene:604","sources":[{"id":"urn:uuid:add6cfb5-95a7-414c-b037-743c1be4ccd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9671","original_object":"UniProtKB:P41182"}
{"id":"cda9751f-c4a1-4f97-aa7b-76c5de27a2af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755148","predicate":"biolink:affects","object":"NCBIGene:20273","sources":[{"id":"urn:uuid:74949993-919a-4b29-b6f4-19f0e6943433","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5730","original_object":"UniProtKB:Q9WTU3"}
{"id":"4185d8fd-b26f-42bf-bbed-2aecfe68b086","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:437","predicate":"biolink:affects","object":"NCBIGene:834","sources":[{"id":"urn:uuid:c1445f02-e267-4a08-a8cc-2017f686d192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:437","original_object":"UniProtKB:P29466"}
{"id":"8abaab65-d141-4f33-801f-340f1182afc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TXG28R7G4Y","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:e55b19cd-798a-4301-9604-615a91fd72da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:496","original_object":"UniProtKB:P25100"}
{"id":"3107a360-3a6b-44ca-82f9-d6efd82f5f5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8L3OAJ1R5A","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:496fad6b-1ac2-42c6-9b1a-c879a8fabfbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8420","original_object":"UniProtKB:P29274"}
{"id":"17cb2a4e-8645-4bda-b3de-c401f3eae5dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153531813","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:e93f6e8d-5b61-4b40-9291-c041199bfb67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12018","original_object":"UniProtKB:P22455"}
{"id":"516baf1b-e6df-41b8-864f-9542df78449f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9891167","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:66b260eb-d3d4-42a7-b4d7-036623b81d85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:491","original_object":"UniProtKB:P25100"}
{"id":"c0b233b4-bd87-44ae-bd7d-e0b6b549fc0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433311","predicate":"biolink:affects","object":"NCBIGene:59272","sources":[{"id":"urn:uuid:50f28ef6-9843-47a1-915c-585b834b3675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12820","original_object":"UniProtKB:Q9BYF1"}
{"id":"6510b712-093b-4109-a3d0-f6dc683f0c3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817385","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:32823d5f-cfe1-4710-8d7c-21f541979842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:923","original_object":"UniProtKB:P34998"}
{"id":"d08c3e0e-1e3f-4570-8663-375690f86e70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95089","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:9876070a-f413-49b9-89e6-f6a320398d47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7887","original_object":"UniProtKB:P31751"}
{"id":"4ac82a72-3f73-44e5-8997-a000260c593a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91452","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:10b9b1bf-a181-4961-8830-05133ba3e9fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9382","original_object":"UniProtKB:P06213"}
{"id":"7942eb3a-15de-4ece-82d5-00652a534303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XN7MM8XG2M","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:48fcd1a5-90df-4a54-bcd5-4795477ec034","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11215","original_object":"UniProtKB:P10275"}
{"id":"88895964-b6be-4431-bc95-28d641600395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13390","predicate":"biolink:affects","object":"NCBIGene:20273","sources":[{"id":"urn:uuid:88a63d4b-8904-4bda-a1bc-c01344d9467e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13390","original_object":"UniProtKB:Q9WTU3"}
{"id":"3631f818-90ea-47a7-b179-0d5dd98f865f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9806449","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:4fd17463-d160-4676-bbcf-0be65defa014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1355","original_object":"UniProtKB:P49286"}
{"id":"713a8699-d1ce-41fa-bea6-de5fe2716c62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63937","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:4788aed1-4bc5-44d4-aa75-7facc9eceb2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:486","original_object":"UniProtKB:P35348"}
{"id":"1e99ed4a-96e3-45d2-a136-231663292efc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13674","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:92651560-3cef-4708-a6c2-bebbf14307a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13674","original_object":"UniProtKB:Q8TD43"}
{"id":"41e57224-df96-4acc-bc18-0da544b8b419","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N65WC8PXDD","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:aaf919fa-6433-4ffb-852f-05c83c4c0b13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7729","original_object":"UniProtKB:Q13490"}
{"id":"ff531341-0d15-4a25-9a3b-3d245c611e2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755212","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:acdd6807-1ac8-48c5-96e3-88a3321fd18b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6366","original_object":"UniProtKB:P31424"}
{"id":"24641606-8a58-409c-a03e-8e5da8d42ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49779607","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:f8a21128-28ad-4c3f-8f12-85e78fdfa8b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8705","original_object":"UniProtKB:P34972"}
{"id":"4b432c9e-be32-4c99-ac4c-be0cb3bfc628","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64317","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:2c87cb5c-47b5-4567-9f21-3fb4b8958473","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:536","original_object":"UniProtKB:P13945"}
{"id":"736f7733-51d6-4e5e-a60d-67246bcca48d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34461","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:c8b08fc6-d536-4178-b479-ed2024f058b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4321","original_object":"UniProtKB:P48169"}
{"id":"7d8b47dd-8103-46e9-8929-436e435b81b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2509","predicate":"biolink:affects","object":"NCBIGene:83795","sources":[{"id":"urn:uuid:daf800d5-b96a-4509-abdf-e9e2a16f0a07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2509","original_object":"UniProtKB:Q96T55"}
{"id":"fd47e8dc-cc7c-4a79-b8ce-c6ec5853c7fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081973","predicate":"biolink:affects","object":"NCBIGene:1536","sources":[{"id":"urn:uuid:ac3f448f-4f87-49fa-b9f4-692c9cfd59e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9933","original_object":"UniProtKB:P04839"}
{"id":"e9f87d76-fb7a-4371-95c1-bee88ed5ba73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70682637","predicate":"biolink:affects","object":"NCBIGene:4363","sources":[{"id":"urn:uuid:a7ba7d23-d63c-4862-8b8e-9d8928018d8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8762","original_object":"UniProtKB:P33527"}
{"id":"d081ff3d-b11f-44c5-a4f0-cdd9db73373a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135983","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:2a6724bc-cc68-48a1-a908-cd289a369979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4448","original_object":"UniProtKB:P25961"}
{"id":"fa49f8ba-d4b3-4879-b3a7-d78057f81926","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:8428","sources":[{"id":"urn:uuid:e928dc72-a9b0-4843-861b-2d9614eb6935","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q9Y6E0"}
{"id":"b214d6e8-0c74-440d-ac85-53574315a6f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87103","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:63d256b8-1a07-4adf-a21d-fd26faf48727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5992","original_object":"UniProtKB:P29597"}
{"id":"5b87a09a-26f3-4b02-84bc-37b32f0db3dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83527","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:8b963d32-98c1-453a-ba16-ee83023d8960","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7158","original_object":"UniProtKB:P31645"}
{"id":"1eb985bc-c94b-45ac-828c-d5ef72cd3160","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59397065","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:b70c8866-2f35-4ead-b891-fec67328b3cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8071","original_object":"UniProtKB:Q16620"}
{"id":"b3e95874-b83c-4d20-9ad6-fb72d38fd2c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137530063","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:43ae7fd5-d582-4fd9-a303-99f38ffe9a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12037","original_object":"UniProtKB:P28845"}
{"id":"72300cac-dd9c-46d7-ab90-c4ffe0398391","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:366ZW99DGL","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:69707f5d-0d07-4110-9f01-657d41492bc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8424","original_object":"UniProtKB:P41595"}
{"id":"5042a9c7-f8b0-42ee-9f9b-10172236a5ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:f7bc350f-f62d-4cfc-a9c9-442cf6b38420","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:P24941"}
{"id":"9a170376-79f5-41eb-b810-6cf00560f88c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3911","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:85801190-f83a-4d24-97bd-1e2b1ee733ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3911","original_object":"UniProtKB:P24530"}
{"id":"1220c104-72bc-40a3-90a7-29cf0e734569","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8297","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:3fd9195e-71f7-4717-af8a-dc2df3bb9baf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8297","original_object":"UniProtKB:P21860"}
{"id":"84653f22-09ee-454f-a3b6-2602cce2292d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7457","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:73c87c0d-6a28-4d80-a54c-37e754614f89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1628","original_object":"UniProtKB:P41145"}
{"id":"1a383dbe-6c06-4f10-8173-4c814eac7597","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138674003","predicate":"biolink:affects","object":"NCBIGene:56474","sources":[{"id":"urn:uuid:c6f9d9c9-418e-48e8-bca9-6951ddb56954","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12314","original_object":"UniProtKB:Q9NRF8"}
{"id":"66ad6eac-97d1-46b9-89f8-2408baa8fea6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I02418V13W","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:e3cbb124-daa3-4c13-be33-04a8b37cba87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9561","original_object":"UniProtKB:Q13822"}
{"id":"7b4c1fa7-7ed5-46c1-b52e-43711703b5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023863","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:637fa9ef-7638-4ac7-a908-cbd4f9cecbd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3195","original_object":"UniProtKB:O95749"}
{"id":"e13ad4bf-2c26-4d58-a820-2ad9aaa3e2b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50942314","predicate":"biolink:affects","object":"NCBIGene:8576","sources":[{"id":"urn:uuid:c3cf267b-8e60-4aec-8f47-a56836d94c6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8210","original_object":"UniProtKB:O75716"}
{"id":"5685083b-8635-4ebd-a32d-7e6b4ba88452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WP6PY72ZH3","predicate":"biolink:affects","object":"NCBIGene:51311","sources":[{"id":"urn:uuid:9780cd2c-05a3-4c61-bfa1-76e0d3325a30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9026","original_object":"UniProtKB:Q9NR97"}
{"id":"02a157f1-774f-49de-8829-dc6fe1c097fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:b5bbba79-466f-4c50-97cb-de05fb183f21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P14867"}
{"id":"2e9696bc-1e6e-4d96-bce1-57df16185b52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146662729","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:413b0a3c-ea45-4e24-8498-2df6eac4f450","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11841","original_object":"UniProtKB:P50613"}
{"id":"f164b6cf-6b52-45aa-9849-d9ac5ba51b60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66662059","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:de26b7fc-fae0-4345-870b-82a66b8f258a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12121","original_object":"UniProtKB:P28845"}
{"id":"b1c7e89b-5af7-428e-9fd6-cef540b81a45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32269","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:4bb92ad8-d9b7-4e72-a483-4c96e4195e1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:260","original_object":"UniProtKB:P23416"}
{"id":"301d850e-1c62-4fa7-bc90-70bce2904dc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358782","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:6756014a-6980-42bc-a417-8853e89cf517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11981","original_object":"UniProtKB:P0DTD8"}
{"id":"1ab9f910-ec34-4251-b254-fe118e12810e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114756","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:0f6611b0-dd60-4900-8430-d6a7d74a5ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4078","original_object":"UniProtKB:Q14957"}
{"id":"befed915-e883-47bf-9613-e7fa28220a3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8205","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:d90f2b5d-647a-465e-a28d-acd280bc3feb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4286","original_object":"UniProtKB:P48167"}
{"id":"9999c098-0a74-41af-ba14-d0089e271707","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:161309","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:85c47d0d-19bd-409a-afe3-e03a95ed18f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:988","original_object":"UniProtKB:P21918"}
{"id":"911696d3-4d57-4693-a598-64f86d6e6886","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:47f9daf2-8a3b-4a23-a068-2701e6ff282a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P28222"}
{"id":"2fc6b756-9983-43f0-a373-7152d1a9e40a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31317","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:2105c3c4-83a5-42db-b5ea-100ad73bf8b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7498","original_object":"UniProtKB:Q969S8"}
{"id":"b046b853-0a96-443e-8492-f070aedc5b8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6109","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:b08b54a7-a901-4009-b10b-f12977b606b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6109","original_object":"UniProtKB:O43603"}
{"id":"83091680-836e-4bd7-bf82-fca142ab48b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:939111","predicate":"biolink:affects","object":"NCBIGene:1195","sources":[{"id":"urn:uuid:e3665dbd-64c4-4a3c-a64c-42f2a25d4ae0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8115","original_object":"UniProtKB:P49759"}
{"id":"56c526c0-5e18-4035-91da-f3308e60056d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996535","predicate":"biolink:affects","object":"NCBIGene:6609","sources":[{"id":"urn:uuid:90ff6db3-9884-47f8-9762-4c37cb40cb62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10640","original_object":"UniProtKB:P17405"}
{"id":"25b93e9d-bdbe-4074-9b70-78ad2406f745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6075","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:1bcc7664-b67c-4bce-94c4-372453528ddf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6075","original_object":"UniProtKB:P47211"}
{"id":"1cb2c3a5-270f-43b5-9334-4c218a7fd679","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EK8WS2OJX0","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:0675bc85-5437-4144-a0ce-14ff78be253b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9889","original_object":"UniProtKB:P21453"}
{"id":"d50c9086-042f-4d27-8253-6c1f1452394c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3NU609VYNF","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:8acf12f0-1666-498b-be60-fefafee0c705","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8942","original_object":"UniProtKB:P10721"}
{"id":"a00d2fc0-80b6-4653-a7e3-33cb1e55a558","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6324645","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:e1a14147-6a01-43c4-8b83-f63bb2f59378","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1682","original_object":"UniProtKB:P41146"}
{"id":"0dfdb031-5e65-4dbd-b7bb-ca011c43df30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:5725fc69-e11e-4bbc-b17b-2f2d667b3a97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P43116"}
{"id":"ad067bd7-8675-4ce8-ba7a-915055e9b02e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566354","predicate":"biolink:affects","object":"NCBIGene:10724","sources":[{"id":"urn:uuid:df6bc5ba-c220-4a3a-b7f7-1612c92ae91c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10509","original_object":"UniProtKB:O60502"}
{"id":"39193f51-e03d-47fe-b6d8-90a9f69d6bea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28077","predicate":"biolink:affects","object":"NCBIGene:6579","sources":[{"id":"urn:uuid:f9f0a453-cc84-452c-b0ca-6f3b0c3ba1a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2765","original_object":"UniProtKB:P46721"}
{"id":"825bee14-3043-46ae-aecd-a5625d23a701","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947022","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:e4f8f314-2d4f-450a-8b76-2aae4b78637d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3019","original_object":"UniProtKB:P51639"}
{"id":"522763de-322a-4257-93d2-770f2f18a090","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JJC99KHGL","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:6182a4d6-5344-448c-84b8-ed75df798035","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11118","original_object":"UniProtKB:Q9UQL6"}
{"id":"412871f3-4021-4bdf-a002-2181e255a9d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130229812","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:8909a423-23ef-42a3-9fcf-0d09c6ef5c98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12709","original_object":"UniProtKB:P10275"}
{"id":"24a45449-ef42-474d-906e-bd0015750090","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3DGD69C6PV","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:7b38f2ed-6461-4e6b-b820-ac22f97c4b92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7741","original_object":"UniProtKB:Q9UM73"}
{"id":"bafd0c00-72d3-4714-af37-f8f88b9ffcee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130662","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:e01c081c-17b5-4271-b0ae-06bd082339c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3873","original_object":"UniProtKB:P41143"}
{"id":"c6d8c7fb-a261-4f8f-a96d-d3581fec2761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78420","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:357cfaf9-82d5-4ca6-88cd-e25ae687ba51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13728","original_object":"UniProtKB:O76074"}
{"id":"23baf951-4e9e-42aa-ab49-312700c5f029","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44349321","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:ba1ca3bf-3ed4-4ed5-b6ad-c8b2779e1b5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10717","original_object":"UniProtKB:Q9NQS5"}
{"id":"dd904321-9508-40f1-b039-21c4f15ba84c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2537","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:05111e84-679a-46f7-82fa-8ac1d2b04592","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2537","original_object":"UniProtKB:P54282"}
{"id":"ee787e95-229d-4042-bc6a-d1da35d468a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CJ1PL0TE6J","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:41650d5e-7877-432c-bd03-8dd99e90f58e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10655","original_object":"UniProtKB:Q96RI1"}
{"id":"227a8a89-a025-4d81-8cb3-9318348f811b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1994","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:d116f6f0-6d8d-4d24-a0d9-436aa3568fe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1994","original_object":"UniProtKB:Q8WXD0"}
{"id":"835aac2d-9c8d-42c4-bc91-e5e69b79d60d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42989","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:98bc9c55-3e48-41a5-9c96-9fd3a6a9bd83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4352","original_object":"UniProtKB:P32249"}
{"id":"bb6be16b-1c4f-4ccb-96fe-f7d76b69cc1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2306","predicate":"biolink:affects","object":"NCBIGene:83731","sources":[{"id":"urn:uuid:e6a7cb25-a46f-442c-b384-19eb8ca2b721","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2306","original_object":"UniProtKB:Q62976"}
{"id":"21b3d245-c438-4fc6-ac12-db02b56fa95f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4050","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:fcbe1654-5965-4a31-896a-6e455798e321","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4050","original_object":"UniProtKB:P55085"}
{"id":"2620cee7-55c9-4e07-aced-1aa35a50328c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B35HB63WZF","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:60807558-5e0e-4bd5-817e-0b38354a9439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13329","original_object":"UniProtKB:P56373"}
{"id":"369dff57-5d3f-4c3d-92b8-7c9fea3e1957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135922","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:5894561e-9984-447a-9683-867b513a701f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7482","original_object":"UniProtKB:P30988"}
{"id":"d2027177-7007-4d0e-9378-6c7ff53a81cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280454","predicate":"biolink:affects","object":"NCBIGene:5166","sources":[{"id":"urn:uuid:4d839b90-1c3d-4b7c-bc2a-d3dfe67e9a87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9350","original_object":"UniProtKB:Q16654"}
{"id":"11542054-1c9d-4698-85a6-43055023a363","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101096","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:4b5a6184-eb96-4c27-b099-c3f97ab18fe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6814","original_object":"UniProtKB:P00915"}
{"id":"dd57d2e0-f606-4124-a40e-98aac9a491de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7035","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:dc43cc13-66d1-48f1-921b-68a5ab412f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7035","original_object":"UniProtKB:Q09472"}
{"id":"802141a4-779e-4998-9490-49f241d85566","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1905297","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:b57fb994-b437-4391-8d9a-b6bd6d582c93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8727","original_object":"UniProtKB:P49798"}
{"id":"668a927f-8f29-475b-89ad-45032846e75f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129606875","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:91dd1075-4ce6-4bf6-9a0f-27ecf85f0dd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10626","original_object":"UniProtKB:P11309"}
{"id":"bf5ad886-570c-420d-8a1d-880746afce78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3NU609VYNF","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:4407b571-f05c-4460-82ac-f971a93b88f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8942","original_object":"UniProtKB:P36888"}
{"id":"844f5acc-ff39-40e7-8349-69e17a4e0f67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7542","predicate":"biolink:affects","object":"NCBIGene:64636","sources":[{"id":"urn:uuid:aa2e49a1-1c31-4c34-ae0f-2f8dfcae5175","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1579","original_object":"UniProtKB:Q63384"}
{"id":"8db5d7a4-49b1-4984-a001-f9563e2a6eff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9249","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:fa955080-9584-487f-ac6f-8e9db20bf389","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10369","original_object":"UniProtKB:P15207"}
{"id":"29f89b78-af40-4482-9cd8-1fde46685cd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91596","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:13721a3e-5a47-45df-a780-44dd2de51d5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1078","original_object":"UniProtKB:Q9Z0U4"}
{"id":"f5cdb777-c941-4b4f-91c1-a1b65f0174d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:6ee34204-4afb-4cb6-b4e8-72ed15ad36ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:P23458"}
{"id":"4f08a141-6612-499d-a5c5-f689d287b247","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U8C5C9D65S","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:1657b530-cab1-4707-986e-b658a8857c60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3953","original_object":"UniProtKB:P23385"}
{"id":"fc8c8189-bd08-43c8-af10-1fd3bf73ec62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755208","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:11a115c4-d968-4f27-9019-44a19a4cbdbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6340","original_object":"UniProtKB:Q13255"}
{"id":"5c0f577c-f541-4275-bacc-b6667fda04c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:ebdb3986-5cba-4570-a1e5-d84591313a59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P08173"}
{"id":"e8f1023d-2c71-4928-8dd8-7ff26fa11451","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91404","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:a291c905-6a55-48c7-882f-0024258df3f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9994","original_object":"UniProtKB:Q08881"}
{"id":"50e6609d-c5ea-410e-9c07-103754a06a3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072551","predicate":"biolink:affects","object":"NCBIGene:56950","sources":[{"id":"urn:uuid:2cf07aba-42eb-4432-9c24-6ab26a4c4f49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8953","original_object":"UniProtKB:Q9NRG4"}
{"id":"5a433e66-48d1-4382-a82c-1ae7f9d3c33f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587567","predicate":"biolink:affects","object":"NCBIGene:227289","sources":[{"id":"urn:uuid:c40548a6-b200-4ca2-b209-c8194fd4075d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11696","original_object":"UniProtKB:Q80SS6"}
{"id":"87fa8c35-ce13-43ee-abd3-1cb64bf41618","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755095","predicate":"biolink:affects","object":"NCBIGene:6564","sources":[{"id":"urn:uuid:cb0279dc-7893-4d54-8b12-f4339d108b64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4499","original_object":"UniProtKB:P46059"}
{"id":"cd5899da-5950-4f1c-8712-60bfedc56ca1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:32844b18-068f-46ed-8e93-d775f5108646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P14416"}
{"id":"c5d90fc4-0770-4e32-bf39-1da3506f555b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7542","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:4824e5c9-81e3-49b9-81bc-1911fcb037b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1579","original_object":"UniProtKB:P20789"}
{"id":"73a67302-8f01-48b5-8f2c-7cb7feecf4ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229652","predicate":"biolink:affects","object":"NCBIGene:629","sources":[{"id":"urn:uuid:d32e7c3a-9b3e-4b26-8716-c88a7d17571a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10710","original_object":"UniProtKB:P00751"}
{"id":"02ec0944-2e68-451d-ac05-a2a8312739ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5ZHA5P4PFX","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:fdabc50c-c340-4478-a33d-6cc24f3ed892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11189","original_object":"UniProtKB:Q00534"}
{"id":"8cb47d89-e62c-4c44-8295-c056f9c9c765","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:6510190c-1b9c-4640-861b-1bf7f2a3a565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q12879"}
{"id":"4a017a0a-9392-4e1c-b759-2595b28ffcb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95059","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:c36e0807-a639-4ad5-9710-62ccefba8da7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9405","original_object":"UniProtKB:P50613"}
{"id":"24512408-6348-42c7-86d5-a1e5dee5704f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44370417","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:acc361d4-2577-42af-b385-56725ca78e73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2971","original_object":"UniProtKB:P51639"}
{"id":"54f4e6d9-cf8e-4598-a289-f1796ab9d4f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135632","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:3eea995b-b6d1-4103-aaed-e1abe822b97c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6432","original_object":"UniProtKB:O15393"}
{"id":"a5bc4479-37ae-4247-ba35-8b3ecc304974","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I3733P75ML","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:5231fba5-a388-4ef2-95a9-4ae08de15443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9910","original_object":"UniProtKB:Q02750"}
{"id":"41a4ab82-49ab-42e2-82fc-2f9c582d478c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:2e7f2c3e-f9bb-40f6-8abf-2c078b3cfdba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:317","original_object":"UniProtKB:P08912"}
{"id":"8ab6eb7b-3429-49e4-8f99-ca0f813c92a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73389638","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:3d634627-300c-43e1-b7aa-57caab1c8028","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9761","original_object":"UniProtKB:Q06187"}
{"id":"77439db0-b402-4455-a278-1573527e22c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RAX5D5AGV6","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:ffacbe50-f84f-4889-9358-bd4201fcf07e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10615","original_object":"UniProtKB:P41595"}
{"id":"b3637a16-a5e3-4653-920d-f531c3e030e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232328","predicate":"biolink:affects","object":"NCBIGene:8192","sources":[{"id":"urn:uuid:f5399f1d-aada-4b5b-b4fc-235d35bdec48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9978","original_object":"UniProtKB:Q16740"}
{"id":"ae41ae59-a6c9-4212-ae9e-5cb4fbc16ab9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70752","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:1609a871-0c90-4129-8e0d-f758303ef084","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6380","original_object":"UniProtKB:P00734"}
{"id":"63cc8416-f7fa-4346-a510-08512f84b185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:3e563dca-7e8b-4fc5-a972-1624f248a334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P47869"}
{"id":"9786a13c-31b1-4096-a2fa-96eeca17b237","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9549296","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:39b809ed-bb65-4efb-8a4e-2e0d8d6ba04d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6047","original_object":"UniProtKB:P43405"}
{"id":"c1ddef37-52f8-4042-9c35-e68ba42d0a24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:74MLR03FLC","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:967574eb-2b7b-41af-925a-cd3fe3924a23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:63","original_object":"UniProtKB:P47898"}
{"id":"2e5f4514-ff74-40a0-ba1b-e8e4289852bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9949648","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:ca59b3da-d52d-428b-999f-a8d215d8c723","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2600","original_object":"UniProtKB:O43526"}
{"id":"66daa3f9-897a-46d1-a4a3-5ca19f64167e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155434855","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:60f81095-245e-4818-aaca-b5bfd9ae023e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12096","original_object":"UniProtKB:P15056"}
{"id":"5bfe4f6f-2c0a-49c6-abde-11014f74363e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1470","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:fd49dc9c-f07a-484a-b17a-dbd5a751af42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1470","original_object":"UniProtKB:Q9HB89"}
{"id":"299d1f9f-dc77-415a-a5d2-89f58d274138","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7930","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:04083306-472a-466a-83bc-a1f051d6f7e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7930","original_object":"UniProtKB:P35414"}
{"id":"a059bead-1346-43ea-bc7d-b8f6bbf5b520","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:55879","sources":[{"id":"urn:uuid:ca36b8b8-e4c4-408d-9cc8-ec8267b8b9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:Q9UN88"}
{"id":"859480f9-d011-4cfb-b4c1-b8d9dd9c82bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135285","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:1cc9e043-501c-4738-8114-a8c4bf8ac82f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6310","original_object":"UniProtKB:P27487"}
{"id":"fbb70516-a232-46ee-95fa-4eaabba5d0eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46943415","predicate":"biolink:affects","object":"NCBIGene:1459","sources":[{"id":"urn:uuid:d1902080-3657-4ae2-b252-bca6d4c46999","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8140","original_object":"UniProtKB:P19784"}
{"id":"6157f464-b48b-4305-b264-4d68934686ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3061","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:e0043cfd-8ea4-4134-957a-2662606c61b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2337","original_object":"UniProtKB:Q9Z258"}
{"id":"99538aad-8aae-4a9c-a0c3-644a3b7927fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:272","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:ef7d437a-148f-4ba4-a024-8d8f14b01651","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1647","original_object":"UniProtKB:P33535"}
{"id":"fbec61ab-a842-4cd6-90ae-32fda2780254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y9ESM282DO","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:99f66fbe-9eeb-45dc-a21a-0be7adc96443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:985","original_object":"UniProtKB:P21728"}
{"id":"59cf70df-afba-4667-ba5b-898ed1b33e95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61397","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:2c186b89-19f3-4f18-b101-24a5153b4ffb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5686","original_object":"UniProtKB:P00533"}
{"id":"74c42c48-48ef-49b6-b42d-2b7e595b7dfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49575","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:b1d41ff4-5bd9-42ac-b8ba-0fff1d65ee89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3364","original_object":"UniProtKB:P47869"}
{"id":"3b451205-848d-4d6a-a77b-7a560b96db9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63631","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:a4d4cd8d-3b8e-4ff3-a116-e79e334e918e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6849","original_object":"UniProtKB:P22748"}
{"id":"05293851-7579-4336-9e05-908c9645330a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138657983","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:dc2cdc5a-b0cd-4307-b144-470a978aecb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12011","original_object":"UniProtKB:Q86WV6"}
{"id":"cd6086d8-c78c-44c4-8271-b7baf6eb92d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6GM6ZN5S1Y","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:5ae242c5-5f2e-4807-ab60-26eea7727bc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5868","original_object":"UniProtKB:Q92847"}
{"id":"1388e8cb-172e-41ea-93dc-32333a250855","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61390","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:b24c6ae8-f2d7-4900-8fb0-de65e2f7e9c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5667","original_object":"UniProtKB:P00533"}
{"id":"16bcd348-de52-4e04-9c65-445af0c46cb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NL5EEM9E2G","predicate":"biolink:affects","object":"NCBIGene:100359982","sources":[{"id":"urn:uuid:0d329321-80c5-4de8-b6f6-55ee685b247d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11300","original_object":"UniProtKB:P38718"}
{"id":"2f823914-5882-4bbf-991b-f92058f1b507","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:9838ccd4-f64f-4242-908b-0edb85c55332","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P34969"}
{"id":"e460b8a6-26bd-4d93-85cf-31aca450f34f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9935197","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:1cfcc297-1b6b-492a-9157-1c1156efc925","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2688","original_object":"UniProtKB:P37231"}
{"id":"ae242b63-f7f0-43b6-9943-94ef75858f6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755070","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:7b7988bf-4380-47da-a3de-5ff47a8039b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4036","original_object":"UniProtKB:O43193"}
{"id":"0a425ec6-d076-499a-a68e-3a5d8116cf7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755038","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:460f9941-f6fc-4f28-8424-339644467faa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3268","original_object":"UniProtKB:P11229"}
{"id":"057447e2-f942-400a-9e5d-85c0923f7b5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30154","predicate":"biolink:affects","object":"NCBIGene:9970","sources":[{"id":"urn:uuid:ed9e35b0-320d-47fc-b983-935d92909a03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2759","original_object":"UniProtKB:Q14994"}
{"id":"41b86c98-6920-4a99-a5cb-59120f359d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5866327","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:143452f4-1946-4710-bbbb-df70242db117","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1416","original_object":"UniProtKB:P31424"}
{"id":"3fa4d28a-3402-4e23-9b98-c9eeba02baec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:8754f662-11ab-4771-a2b3-34166febf83d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P08172"}
{"id":"06b510ac-eb48-4f5c-8f51-95f534fb2898","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311116","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:73e55c67-31d3-49f7-849a-1ac6b40dd3d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:544","original_object":"UniProtKB:P08588"}
{"id":"24340c19-be8a-4013-b101-1d54f24e9a51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:641f54f9-2252-45f5-8a20-20f10320f8c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:O60674"}
{"id":"481b68fa-48a8-41ca-acd4-7196b38eed54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233412","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:1d076913-acf6-451e-9069-ea84a6013597","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9320","original_object":"UniProtKB:Q99500"}
{"id":"3e54eab2-45b0-4d51-85d5-b004f0a7a532","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:679906","sources":[{"id":"urn:uuid:923e30c5-9645-4799-aef9-c2550ca8c575","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:710","original_object":"UniProtKB:Q925B3"}
{"id":"19cb0ccf-4d12-4103-9bdc-127c0587eaba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4470","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:7c9ff60e-428f-4eb1-b9c9-e796f6f327f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6953","original_object":"UniProtKB:Q9NYW7"}
{"id":"b75bf1e4-a7e7-4217-b516-9db2ed99770f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46261","predicate":"biolink:affects","object":"NCBIGene:5726","sources":[{"id":"urn:uuid:a7e360dc-e61f-4b21-97fa-3ad396c9624d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12496","original_object":"UniProtKB:P59533"}
{"id":"0881cafa-8747-494b-9823-dcc5e68bd7a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65346","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:323f9320-2ba3-4a8c-8575-7e0c95aeb654","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7449","original_object":"UniProtKB:P08172"}
{"id":"96ca6ff7-a8a0-4a5a-8692-18414b2b89d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867750","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:b2b4ae9f-497c-44c1-9dc2-01effbdb104f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:350","original_object":"UniProtKB:P08172"}
{"id":"2cc33085-0088-4b7e-bb1a-b1083bce67e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10348659","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:daf5e49e-a93e-486b-8e61-445315fd2274","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:866","original_object":"UniProtKB:P32238"}
{"id":"cf374f57-3b83-4933-9fdd-c1ba6ce37c0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11441554","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:fffa3523-9ee1-4f06-8f23-9ddef09bb234","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5871","original_object":"UniProtKB:Q92847"}
{"id":"a6ae33f2-c14d-400b-9827-7eb821c19133","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6839","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:a023f682-4f9e-44aa-9a72-54a0b71ed82d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:483","original_object":"UniProtKB:P35368"}
{"id":"61f846c7-8d86-4cac-ab02-bf9b4662f7e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:09fd1c05-bfa0-404c-8645-ee5d737c6721","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:Q60614"}
{"id":"5ef12d96-0ab1-425c-924a-7c0d7d42f9e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9793868","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:3544edb7-2e3b-4780-a38a-43505a2396c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1252","original_object":"UniProtKB:Q9QYN8"}
{"id":"2202478e-aa58-408e-978a-105a0c4d8a79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:cb62aae8-c706-410a-af70-cc9e61137396","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P48542"}
{"id":"e8777149-ef1f-4490-9691-c2fb33e5fb66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:a0e3a605-ed84-45b2-8d3e-b7be278df64e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4192","original_object":"UniProtKB:Q16445"}
{"id":"b345484a-7fbb-423e-a176-ebcf7db42a2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9936595","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:06203417-da31-427c-abc5-c84a75054506","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1921","original_object":"UniProtKB:P35375"}
{"id":"23834f23-9388-4445-b790-df554f3234b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71271414","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:f8d36425-00f8-44f9-a57d-4a97657b7aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12323","original_object":"UniProtKB:Q9Y233"}
{"id":"aa543eb9-14df-4a02-8ed0-88ee402479eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3644637","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:5bb6e57c-1559-42e2-b273-40600a823a7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:193","original_object":"UniProtKB:P28335"}
{"id":"5953b656-f1d9-4937-bd70-298472238408","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CW55R761RE","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:5f996614-5cd4-4143-91c2-e33f1b149c5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:290","original_object":"UniProtKB:P08912"}
{"id":"2f96c378-8cd6-4f10-b79b-d7ec233284a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12060","predicate":"biolink:affects","object":"NCBIGene:3604","sources":[{"id":"urn:uuid:ce3a7e0b-39f8-429a-b036-3da01dc7d65f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12060","original_object":"UniProtKB:Q07011"}
{"id":"0a271ad2-54da-4306-8894-0eb6d7404c73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72202254","predicate":"biolink:affects","object":"NCBIGene:699","sources":[{"id":"urn:uuid:7071c76e-ad2d-43a9-9b87-65fed3c7c6a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8109","original_object":"UniProtKB:O43683"}
{"id":"de7754e9-af0d-4b00-ad78-34e32be5d443","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311469","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:66fece91-b23e-4493-80dd-772fc8dbbe3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3913","original_object":"UniProtKB:P21451"}
{"id":"ea51a2a8-4d9b-486a-97fa-20acb1c2a2f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125411","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:310c0fdf-4b4a-4d81-9020-6f08b21163c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:215","original_object":"UniProtKB:P41595"}
{"id":"5eee3e40-8a45-4e07-95ec-ef06c4c36fed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71624782","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:e9e5771a-8fb3-4202-9c8e-22c33c8956b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7517","original_object":"UniProtKB:O60885"}
{"id":"fb40b3ff-a06a-4beb-9f6c-80842a764a68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4B93MGE4AL","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:3876d922-23d3-43cc-b3e8-62302b46c9cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9786","original_object":"UniProtKB:P11362"}
{"id":"3934bce4-189b-4521-a323-9c52ae107a59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9101","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:0d29c7dc-1efa-41ec-92ab-445c327fdf56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9101","original_object":"UniProtKB:P53779"}
{"id":"a06c4cba-e6fc-4dcb-aa4f-eff2fa4d5ed1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70789348","predicate":"biolink:affects","object":"NCBIGene:9099","sources":[{"id":"urn:uuid:0d0bf3d9-ba22-4a85-874e-cc58b3289934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13057","original_object":"UniProtKB:O75604"}
{"id":"fc968f52-3d2e-4f93-a36f-e2b29c7bd18b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44370459","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:6ebfb20f-a2a4-419f-99b4-492e318be07c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2968","original_object":"UniProtKB:P04035"}
{"id":"7e69ad91-6af6-4ef7-97c8-5da34990397d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24856225","predicate":"biolink:affects","object":"NCBIGene:51400","sources":[{"id":"urn:uuid:edf55415-d563-431f-b53f-61e644abbb9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8608","original_object":"UniProtKB:Q9Y570"}
{"id":"b3e28233-2118-479a-ac38-2153772c4ecc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SA2ND7EHY4","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:d297b519-0fa4-44e9-a0e4-09c9d43754b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8836","original_object":"UniProtKB:Q16539"}
{"id":"d1f5923c-7c74-4521-8feb-01edc67fd5d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:40d1db5c-fad0-4114-8a45-c6d71b24412c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:P11802"}
{"id":"d0fe6c9d-c6d7-493e-882e-1efd508903af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755062","predicate":"biolink:affects","object":"NCBIGene:2854","sources":[{"id":"urn:uuid:650fa152-5962-444d-8a6c-f3dc3c256e33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4356","original_object":"UniProtKB:O75388"}
{"id":"ea63fafe-fa7a-41f2-aee8-a9c747ceedfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:8410c8ff-303a-4aa0-9939-511ea82bea9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P21917"}
{"id":"df4d788d-6727-47d0-ad50-19e2c498f901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156821173","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:65e2d975-7bba-4e7f-af62-8a62d5e8fa36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12164","original_object":"UniProtKB:P04626"}
{"id":"4524a128-6514-4409-b224-64946bb75507","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:a2b5fced-06b1-42ce-9d4c-b7db6e3d1f02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P28566"}
{"id":"88b4076b-ce6e-490c-a394-11c8fde0fd88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10132921","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:6d760f06-b856-48dd-9afc-0efc11f814a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9458","original_object":"UniProtKB:Q96RI0"}
{"id":"267bf0ff-a7ba-4fa5-a495-04230c3890b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:9a9577b1-c6ed-4a4e-b464-cb75e1e1ca5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:Q96G91"}
{"id":"dfb8ff68-e48d-44ab-9607-5efe8713c079","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y778RDH3Y6","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:b94d24fd-2514-4770-acfe-c98d5a8ac00d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1304","original_object":"UniProtKB:Q99705"}
{"id":"7674dca6-0795-4992-bb39-a4e84b33f9de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10211","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:ab7783be-81b3-4eb7-a7fc-f4f24c444ecf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10211","original_object":"UniProtKB:P16066"}
{"id":"68a876bf-ecde-4be2-855b-523759bd5fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1988","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:1c93c4f5-690c-4b80-b0ee-c9b77e191635","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1988","original_object":"UniProtKB:Q9HBX9"}
{"id":"c39c1a8d-b070-4788-8ab5-2caf7e2c6421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11551","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:2e72380e-215a-41d4-ad34-0ac224a231f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11551","original_object":"UniProtKB:P0DTC2"}
{"id":"2f14a82a-8689-4119-b2ea-f5f6c64abb4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:d3f77179-8ab0-4f4b-99ac-0e37146073dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P14842"}
{"id":"b7330b9f-d150-4851-9d85-8ff44353cc6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135377","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:b7f84b9f-6d4b-44d0-986b-8204ab07e962","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:552","original_object":"UniProtKB:P08588"}
{"id":"2813c950-2ee5-487b-9e8f-060d0f74a72f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N3Z657H81X","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:e551f280-c742-4a9a-8c26-2e59aac30ab8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1547","original_object":"UniProtKB:P49146"}
{"id":"521102e2-bfea-45e4-9c3f-238f1f415b94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:13efc23b-7db5-4b11-b042-b5d1b4b5c001","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P28223"}
{"id":"9d677428-6080-4dea-a5d5-00697290f438","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:3d150130-ab37-43ca-9477-491ea88a7bd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P30994"}
{"id":"bf26a98d-2699-45f1-be45-37629ce9d0c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143114","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:3919873e-b451-49c8-b73c-7a59a405ccd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8945","original_object":"UniProtKB:Q9BWU1"}
{"id":"9f2f65f3-94ec-47ba-a878-fdf9dc7e99b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:29559","sources":[{"id":"urn:uuid:fe143818-677f-4e6c-92a5-01e4041a0a9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4317","original_object":"UniProtKB:P22756"}
{"id":"89a5eef1-8f7d-457c-b54b-14aba1d9c462","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24743936","predicate":"biolink:affects","object":"NCBIGene:3786","sources":[{"id":"urn:uuid:41bf6632-0098-456b-93df-6d0a1b45066d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12650","original_object":"UniProtKB:O43525"}
{"id":"e4478b45-1f08-4fda-8c7a-2744acfdfc07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122594417","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:349162e7-2d41-4187-84d1-bf0f94070230","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11289","original_object":"UniProtKB:Q12879"}
{"id":"082bb190-f438-470c-a59d-5631d4196ff8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9720","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:a69af1a7-0910-41f4-a530-ddd485d2416a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7315","original_object":"UniProtKB:P11229"}
{"id":"13c58ad8-8c63-4905-8877-6901abf93b73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:58caa686-7d8d-42d3-a9b0-88e5725a29e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P08913"}
{"id":"630465fc-ab8c-4d4c-b3a7-f4f34dd22254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817434","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:28c3bb1c-bd8f-4b45-adcb-c880a1df26fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1828","original_object":"UniProtKB:P49190"}
{"id":"3264deff-55fc-43ac-a0d4-d2e0e4288ba2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2574","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:cf1e058d-fb35-42a2-85be-fa11d228fb00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2574","original_object":"UniProtKB:P15387"}
{"id":"a05fa8d0-b31b-41d5-9e08-e1199492ac88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91368","predicate":"biolink:affects","object":"NCBIGene:5582","sources":[{"id":"urn:uuid:0b8aa8b3-d841-490b-897b-b51439954d69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5693","original_object":"UniProtKB:P05129"}
{"id":"a492158a-e82b-4598-8b76-549d17293f06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44405854","predicate":"biolink:affects","object":"NCBIGene:24247","sources":[{"id":"urn:uuid:7dbdbf45-c711-459c-9313-c25e37c82ce4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:711","original_object":"UniProtKB:P48442"}
{"id":"91c245a6-f1ff-4a77-8f95-a09aed37499c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136538","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:e21a17e5-df48-4681-90cd-4ca48c39f082","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4186","original_object":"UniProtKB:Q9P0L9"}
{"id":"517c497b-4be3-4e4d-9964-ab8411be45a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50922685","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4bacfc4f-178f-4a4d-9d46-39e5eafb49ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9294","original_object":"UniProtKB:P35372"}
{"id":"8f7a2a4a-172c-4e9a-ace8-e623d17455ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44475955","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:443376b5-06da-4ec3-9239-5d29295607d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5437","original_object":"UniProtKB:P11229"}
{"id":"694e760a-fd78-4ad9-ac29-7a8a0468c351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8S5G34WY1","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:0cb3da23-68c3-46e7-b9ed-c0c036936eb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11024","original_object":"UniProtKB:P25090"}
{"id":"1512e3a2-ba8f-4d06-a48c-cf049e7b1658","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358908","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:89574523-5432-4707-b515-1bc3f1c6d961","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:344","original_object":"UniProtKB:P20309"}
{"id":"1ffd484b-48b6-44fd-b157-3245590fc981","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46891771","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:6df6cca7-2a8b-462a-8516-968d2b709aa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11496","original_object":"UniProtKB:O95136"}
{"id":"ce9212b3-2483-49ca-a3d8-6a11adbb01dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228346","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:85df4d39-ae10-45d5-8cfc-46dc5ce559c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10454","original_object":"UniProtKB:P08908"}
{"id":"fb511293-015b-4c2d-878f-38058b6a7984","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101278","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:47bd0350-5831-4a77-8871-90995a77a4a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2298","original_object":"UniProtKB:P63142"}
{"id":"94f30d3c-c1d5-48c3-9805-6fcaadf203ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135197617","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:70e4099f-db3f-4a74-8553-324ab08b57a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10441","original_object":"UniProtKB:P42338"}
{"id":"042d5d2b-2c7f-40cf-9e9b-82fd1942bfcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:dfc04411-5ff9-491a-9de7-f2545437102f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:P21453"}
{"id":"36e5dc6a-42e5-444e-918c-de8a261e5b3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166560233","predicate":"biolink:affects","object":"NCBIGene:6098","sources":[{"id":"urn:uuid:50ec45f4-f0aa-427a-a5f4-e6846010e583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12392","original_object":"UniProtKB:P08922"}
{"id":"4b67f195-d371-4c5a-a490-cd262791ebc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10404587","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:b0338bd6-4d35-4d48-b12b-4038bd06e769","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:251","original_object":"UniProtKB:P97288"}
{"id":"ab55db35-2fa7-4bf9-a003-78213f1bcb9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311134","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:8ae5c540-b432-49e2-8b84-da93f58876aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1349","original_object":"UniProtKB:P49286"}
{"id":"d449eba0-57b7-4732-9640-dae28f0e9bdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6324606","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:bed1fc3a-c94e-4327-bbdf-81bb784711f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3771","original_object":"UniProtKB:P28336"}
{"id":"7610e88c-534e-4900-89ba-19f4e726f2cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57559562","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:92efa99d-5d52-448a-b424-1cfc121b4705","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6365","original_object":"UniProtKB:Q13255"}
{"id":"01dc9dc9-d6fd-427e-b1b4-5ab7ee56dd0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2086","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:e1abd903-3bf1-4e3a-af78-83e2ac8a5a5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:145","original_object":"UniProtKB:P30939"}
{"id":"98967976-0cdc-41f6-b9e6-522d92ca78fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4CT4CS5BA7","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:da651e31-dbf6-4224-939a-7874ad5a2dd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:273","original_object":"UniProtKB:P50406"}
{"id":"8bf00cb8-31d9-44fb-b614-a0ec904b6c09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1039LG569Y","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:45af86da-2ed4-48f8-a181-4b93fd9ee22a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1258","original_object":"UniProtKB:Q9Y5N1"}
{"id":"72bb4cf5-4b70-489f-a674-c75bb485c351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755062","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:0efa5267-48f3-4e8e-8f35-d3eaa2658b19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3934","original_object":"UniProtKB:Q8BLA8"}
{"id":"880a4f55-fe58-4227-bf89-73247e62e348","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422754","predicate":"biolink:affects","object":"NCBIGene:7486","sources":[{"id":"urn:uuid:7b0b9ea3-c4df-4925-807e-7610d2f39f10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13019","original_object":"UniProtKB:Q14191"}
{"id":"201d2816-dde0-4e6d-900a-d97e233b8ad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49960","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:27377c04-b443-4bc0-8fb4-88527461bcc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5717","original_object":"UniProtKB:P35968"}
{"id":"1047ef9e-5995-4854-8e6e-3b9775eb6088","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146502834","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:0cbe33c5-4112-40b9-8c94-6a33ff22b0db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13068","original_object":"UniProtKB:P24941"}
{"id":"e57454de-1ab3-45c2-9ff6-1038c3d28c9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:b4806b58-5d9e-406c-9072-f90c9fa2268e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P43088"}
{"id":"f397bcb4-4884-4501-a262-db365fc3a126","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92361","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:4122778a-825d-4302-aff6-076933f9e2d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:405","original_object":"UniProtKB:P29274"}
{"id":"d60a4e14-6822-42b7-9d6c-e145ba221e4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5296","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:30b21582-83e9-429a-bb06-b83bbe723565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3439","original_object":"UniProtKB:Q9NPD5"}
{"id":"a7492af9-e7b7-4df2-bcdf-38f2c8f92554","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155195529","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:aeaea6c8-4c83-4941-9793-6ac28aec5fa6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11747","original_object":"UniProtKB:P07333"}
{"id":"c590f801-a221-4cb7-a7d1-9f0207c8753b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6105","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:1060fe82-afab-49c9-b825-f55424a38177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6105","original_object":"UniProtKB:O43603"}
{"id":"01ce941a-b645-40fa-b8e2-90463e961cf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49779607","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:11abdcad-cc1a-4766-9d99-33ae29a2fbe7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8705","original_object":"UniProtKB:P21554"}
{"id":"86331dcc-872b-4720-b7ae-4f8b507cbe86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137628658","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:d73ed88a-3a99-4653-9620-e001e68612cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10532","original_object":"UniProtKB:Q00534"}
{"id":"d5e4ed7e-df56-4707-9101-3c19ada79ac0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37325","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:9add4862-96b6-419b-b140-1eee462183d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:456","original_object":"UniProtKB:P29275"}
{"id":"075e28b5-59f4-4149-8a4c-a901ba6eb491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553172","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:e77932e3-cd9a-437b-a00f-d2e789496e8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10340","original_object":"UniProtKB:Q9H244"}
{"id":"f7691034-52cc-4078-87a2-0996c1636af3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452041","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:ba38d2f5-54ce-49e7-b542-a38456c6ba5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9189","original_object":"UniProtKB:P14416"}
{"id":"b474e65c-1a0f-4bac-93d2-1643bf6d9faa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:16516","sources":[{"id":"urn:uuid:e243f595-5372-437d-b8f1-4e0b5b3378a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:O88932"}
{"id":"f19fe94f-81e8-455b-bf19-0ef307de209c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9840951","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:4aea9087-63d2-461b-9319-482129771e79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3347","original_object":"UniProtKB:P23385"}
{"id":"8a8d1102-6248-4bcc-b100-3a379ddce497","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71458575","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:a2247651-02a0-465e-9517-280fdc3eecd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8827","original_object":"UniProtKB:P48736"}
{"id":"fbbb9006-6bf3-4d07-884f-a179279e175d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124037381","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:202f343c-3c58-4ea9-baeb-383d1cb9d9ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9391","original_object":"UniProtKB:P07948"}
{"id":"6c26a62b-c7d8-4ad4-a61b-06e45a133c07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4890","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:c4c1cc06-0830-400a-95b8-49accb973b65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4890","original_object":"UniProtKB:P16066"}
{"id":"f67d5d4e-e4b5-4046-8cee-6b35454b715a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3813","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:0ca7ef7a-06d8-48c9-a067-bc9dd078fdf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3813","original_object":"UniProtKB:P37288"}
{"id":"64bd355d-0b58-4f4c-96ba-de2ac0f30b42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:5590","sources":[{"id":"urn:uuid:ec8f6147-48b4-46e9-b8d3-a8d4c1dbb81b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:Q05513"}
{"id":"f82810e0-246c-48d0-9560-c2ca484e69b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91541","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:f4a5aa8e-d5e9-4c40-bc1a-eb393c8a2775","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:330","original_object":"UniProtKB:P08173"}
{"id":"66e59997-ad0f-402a-90d4-02fa56e31b26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94777","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:664b20ad-a488-46a8-8aac-c746cd9af344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7556","original_object":"UniProtKB:P14416"}
{"id":"97832a54-fb7c-4cde-b718-efd861343c71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611892","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:db7d878f-04cb-4cc5-9476-eca623715a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9992","original_object":"UniProtKB:Q08499"}
{"id":"9973127c-1d62-41c4-91d7-07a78889ca7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92140","predicate":"biolink:affects","object":"NCBIGene:24408","sources":[{"id":"urn:uuid:230bb71d-fcd4-4a62-be5e-be17e70d0d09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4240","original_object":"UniProtKB:P35439"}
{"id":"46c5bb87-1a92-47bf-af77-d77151c5c516","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118660867","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:057eb92d-be8c-4297-9a23-a7f76f050599","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9170","original_object":"UniProtKB:Q9BWU1"}
{"id":"478714eb-1c09-4c99-9649-466071c50d8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:24338","sources":[{"id":"urn:uuid:d5c52ec2-d436-4828-bcc6-a894567eefe4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P09759"}
{"id":"6c2e55e1-767a-4f82-958b-2042804370a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92263","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:fa4508bc-7fcf-44c6-92d6-2a3b9f11ebc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4179","original_object":"UniProtKB:P47869"}
{"id":"8b7a78ee-d487-4ce1-ab77-7fe032b142ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135899","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:ba121ae5-5c25-4b65-8d0b-dcfb4a578863","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2213","original_object":"UniProtKB:P30559"}
{"id":"ff0e253d-14e4-4d3e-a527-374fbc4f9a52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94513","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:ae3abe8b-0987-4bb6-beec-af014030ced9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6828","original_object":"UniProtKB:Q9ULX7"}
{"id":"4133a92b-a869-45a8-841a-d819f686fe52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3846","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:4d213b77-5987-4273-a0e8-407d7ad91b10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3846","original_object":"UniProtKB:P30411"}
{"id":"7233d5f3-ad15-400e-8ad9-d9fc0d5e4eb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6904","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:64687054-aeb2-464a-b697-1cee733c5a48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:553","original_object":"UniProtKB:P08588"}
{"id":"dc7ce3bc-b49e-4eea-8d50-79effb0ec888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4019","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:42f6a64b-996c-4145-9a14-35e22c491dfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4019","original_object":"UniProtKB:Q9GZQ6"}
{"id":"5665d04c-3aee-44d9-b8a5-400a0c611355","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17688","predicate":"biolink:affects","object":"NCBIGene:65195","sources":[{"id":"urn:uuid:63e4ed71-f34f-40a9-9ae8-f18e2a86d59d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2585","original_object":"UniProtKB:Q62897"}
{"id":"2e1f39e0-c160-497d-a24d-4aac86cc5593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P76B05O5V6","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:993e388f-305d-42ff-a0c8-8986b5247266","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5586","original_object":"UniProtKB:P30969"}
{"id":"9b527f35-5bfd-4c92-bbad-9c4ec2d6f1e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63622","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:c0b142c4-0300-45ac-9327-9a42d619bc5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7297","original_object":"UniProtKB:P08588"}
{"id":"e5d6a219-367b-49b7-86ad-e2b2916bb749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:116337","sources":[{"id":"urn:uuid:4861df81-7631-4a31-aafc-14771682432c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q96QZ0"}
{"id":"67575729-a356-40db-b323-82ccf2cdbfa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85102","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:c5cfbcca-2f3b-4310-9aca-d9e47af9c2e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:338","original_object":"UniProtKB:P11229"}
{"id":"f3320bf9-cb1f-480c-8a1c-6a7dae4944ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125533","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:22ef069a-2db8-4a16-9294-7e1ceb244121","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:216","original_object":"UniProtKB:P41595"}
{"id":"fa7cd00f-2585-4473-b2de-86e649a04f24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:76eb435b-ebb4-4b3e-9580-f557cae4a8b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:Q62928"}
{"id":"12bbd297-c73a-45c7-888a-b0a77a9d7cbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80271","predicate":"biolink:affects","object":"NCBIGene:60432","sources":[{"id":"urn:uuid:6e308c15-de0d-45e3-babe-859b261f7575","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1140","original_object":"UniProtKB:Q9Z0W0"}
{"id":"8cc6f990-6369-4ec6-abea-2859533bfbd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AH2E5UQ11Y","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:aad36646-d0f7-4525-ab3a-e0d4c02a2760","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9012","original_object":"UniProtKB:P97612"}
{"id":"af118652-4ca6-45f0-89bc-dcf0c1f459fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:bbfe8db5-ab2c-41b7-b8bd-5b6190e94f1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P28647"}
{"id":"02049337-3cb6-429f-a2f6-80f20e6fd684","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11326","predicate":"biolink:affects","object":"NCBIGene:929","sources":[{"id":"urn:uuid:899c70b7-3df6-4cf8-8a89-dff025356292","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11326","original_object":"UniProtKB:P08571"}
{"id":"cda986e1-35e7-43e3-93d7-d553ec89b859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165437866","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:ff298166-fd2b-4c6b-856a-52aacf2e5381","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12266","original_object":"UniProtKB:Q13153"}
{"id":"67835800-61e4-40c6-b1b7-f71ce5f932c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167636","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:e1c8ddb6-d7d4-4acf-bfd5-479c50cbd92f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7332","original_object":"UniProtKB:O14965"}
{"id":"265d6c37-bd01-4395-908c-151060cbeb79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4798","predicate":"biolink:affects","object":"NCBIGene:347411","sources":[{"id":"urn:uuid:e0339a54-0b05-4657-a081-9a32feda0dd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6647","original_object":"UniProtKB:P0DKB6"}
{"id":"593a18b9-8e42-4d66-b3cc-5f4c988a783e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q8L6AN59YY","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:11e4c142-143d-410c-a340-d94d6692cede","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7546","original_object":"UniProtKB:P48067"}
{"id":"51b59c41-3f27-4c8c-a151-1924e70783df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41804","predicate":"biolink:affects","object":"NCBIGene:1548","sources":[{"id":"urn:uuid:91e9b5fc-43a8-4fc9-8a2b-aae0cf90138a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8754","original_object":"UniProtKB:P11509"}
{"id":"660a3b27-5e46-48cc-a6d2-81a4cdcfb763","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287548","predicate":"biolink:affects","object":"UniProtKB:P49356","sources":[{"id":"urn:uuid:9a3a91c6-41b8-4485-b8e7-1137e882cabb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8030","original_object":"UniProtKB:P49356"}
{"id":"67791beb-02b9-4dcf-8d3b-f0d432f51896","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:a23d03b8-0f06-46d4-b072-58176f5e1211","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P30939"}
{"id":"7075e27d-6f8d-4cc1-b864-df16d82a14fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136059718","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:3c4cfefb-4a8a-4563-a10d-2e6abb9e2035","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4588","original_object":"UniProtKB:P31639"}
{"id":"dc509098-1671-4ca1-87aa-aa2fe8fcb6bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8586","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2a6789c9-f64b-4cc8-b27c-7fab2efe90bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8586","original_object":"UniProtKB:P08172"}
{"id":"5fc08135-bf66-4ff9-be5d-eb9bd1141a87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:d4fe3fbc-d2da-43d5-bf77-c12e56e3a3b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P21918"}
{"id":"051ba415-a017-48b0-838d-9da588272240","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4087508","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:5cb77b9d-41d8-45fb-af98-c41666866d24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12404","original_object":"UniProtKB:Q16445"}
{"id":"26abba31-33bb-4308-bc0a-0dede127061a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4370","predicate":"biolink:affects","object":"NCBIGene:2829","sources":[{"id":"urn:uuid:f9026845-e599-4b94-b09e-f1ca73d4129f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4370","original_object":"UniProtKB:P46094"}
{"id":"db375db3-6f86-4af4-9460-3510723474e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129053491","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:e14201ab-cfd0-4af7-9714-ec94d0ced036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9973","original_object":"UniProtKB:P28482"}
{"id":"01995f32-2ab2-4843-95a2-a43bec1b6a2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130345110","predicate":"biolink:affects","object":"NCBIGene:4015","sources":[{"id":"urn:uuid:978be54c-c745-4840-a745-2087dcc383b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10486","original_object":"UniProtKB:P28300"}
{"id":"2381b338-3627-4ffc-9679-09806f29a522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221650","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:fbd8a24e-5b3f-4c71-bd90-276486baa3cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9470","original_object":"UniProtKB:Q15391"}
{"id":"ad3a0aab-704a-4917-bea4-bf07fe6263b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1546","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:04c7a37b-78d4-4d08-9db8-347d6e6e111d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1546","original_object":"UniProtKB:P50391"}
{"id":"ef960bbc-b3c2-4f9b-a993-68d752449118","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:12748","sources":[{"id":"urn:uuid:db44e809-93ca-42c5-8671-3ebb39b6ece1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:O35491"}
{"id":"e4148902-9c8e-4c55-8de9-92451a55c950","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK8OFX8K7F","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:8eb68ccb-c1fb-4d77-8419-5114b9428742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9330","original_object":"UniProtKB:Q07343"}
{"id":"a9f23c2d-24b5-43b2-b5c1-f14739029368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817487","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:05995218-2216-490d-9761-f09bb69f3ee2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6130","original_object":"UniProtKB:P47211"}
{"id":"765d5cb0-e0f1-43c8-9b73-8f5d64efff8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:eb216d96-b4fa-449c-9738-9277ebb33533","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q9UHC3"}
{"id":"ae4f99c2-99df-4d44-9012-2e0bf3cfad21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:fcbeae91-7bad-44de-acd8-81f0e2194b07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P35367"}
{"id":"47c0d0c9-bd86-438e-89f5-fc2c07464cd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9674","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:88663533-5142-46e0-91dc-7538f813c269","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7313","original_object":"UniProtKB:P14867"}
{"id":"66b8336f-af2a-45c6-87f3-e8c9cc15313c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194079","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:1dd04863-4c49-4ad7-9608-070499b3f1dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9817","original_object":"UniProtKB:Q92508"}
{"id":"3dac29d5-1384-4e53-8f29-ce63af22a4c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44208891","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:0e5a4c80-7b97-48d5-894b-ba87f555fecb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1348","original_object":"UniProtKB:P48039"}
{"id":"a729375d-970c-43f6-83ba-18579dc941ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:540335","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:8ce6557d-ca3f-464c-91b2-a60e3c6d2e38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3930","original_object":"UniProtKB:P18825"}
{"id":"4eb14cb2-8c05-4065-beea-f27a5ea69531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H35JAI9M2X","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:8bc984b8-c221-4127-b880-8fa49662eddb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10115","original_object":"UniProtKB:P31391"}
{"id":"7725e34d-0b10-4279-ab99-10ec3427b9e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46213069","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:0abd008c-d6a7-4f54-840a-21e6d05888d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8538","original_object":"UniProtKB:P43116"}
{"id":"7bc5ac99-9709-432e-85fb-d7b825d76a76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:913","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:1eac8786-a8bf-4a11-a863-c0d895ab4777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:913","original_object":"UniProtKB:Q13324"}
{"id":"eddec205-c130-48e3-bbb7-5d9c188be2de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52946595","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:69cb9e4c-6710-4447-a488-8e0acb98ed57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11515","original_object":"UniProtKB:P25774"}
{"id":"1bf30dbd-d7ba-47bd-82ab-42bd4c8b1b9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132927","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:9700fcfa-e8cd-4bda-a3dd-f6d12a51594c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:677","original_object":"UniProtKB:P30411"}
{"id":"0ebc20f4-ee4e-47a6-8720-81a13f2f26b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2Z3DQD2JHM","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:b1e25774-3b23-442a-93f7-cc7c97c485c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11328","original_object":"UniProtKB:P0DTC2"}
{"id":"15092764-649b-43ce-a76d-48c7a3e1fd69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68558","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:59df4c9a-4cd0-4a2a-b462-5d5d9d7472de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1765","original_object":"UniProtKB:Q9H244"}
{"id":"6da88fd4-2aa0-4c79-b349-1e00dcb30dc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9816339","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:0065c7ec-f766-4b77-aeec-ccbca7df26b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1361","original_object":"UniProtKB:P48039"}
{"id":"e474a6d5-e4d3-47c8-b30d-51852d794851","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15968","predicate":"biolink:affects","object":"NCBIGene:6535","sources":[{"id":"urn:uuid:041fce57-73cc-4396-871d-7690ebeb7d63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4707","original_object":"UniProtKB:P48029"}
{"id":"ffc25d1b-5bcf-44f9-8b8c-81381edc8c7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9453","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:748c0cf7-5fb4-4ee3-845a-4889979e66a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2608","original_object":"UniProtKB:O95259"}
{"id":"ef37e65e-a97e-4c77-bdbe-4e1e8613c319","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63453","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:2b3ec7c3-6161-4141-b01d-528ffb77db91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7707","original_object":"UniProtKB:P35968"}
{"id":"dc39fa57-1142-4a8a-97a4-e656ac3a3eb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817464","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:80fcd9be-bb01-4dc9-8e29-0ac0fb29ccd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3866","original_object":"UniProtKB:O08726"}
{"id":"71515da7-008f-4d7d-a97d-a3a7b9764648","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993642","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:d18d316d-af54-4763-90b0-9f91c37b9530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12412","original_object":"UniProtKB:P00533"}
{"id":"de92c853-8ada-418a-8738-c1cb691e248e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194548","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:628e55a7-3029-4998-ae94-ec100be14d53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:509","original_object":"UniProtKB:P18825"}
{"id":"abeff69d-5216-45b2-bb94-71f7a6ae6195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8R4A7GDZ1D","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:9bd17246-0fb3-481e-a2c0-91cf9ac4493c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7034","original_object":"UniProtKB:Q15059"}
{"id":"7d2ee254-5278-48e9-95af-f8ec2a70ced9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:158617","predicate":"biolink:affects","object":"NCBIGene:12288","sources":[{"id":"urn:uuid:5e5e0e3f-d93d-4c32-9496-3308b6775b7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2733","original_object":"UniProtKB:Q01815"}
{"id":"e449d9ab-e219-49db-89cc-7195682cd25e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11375559","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:2e24e385-d35b-4106-a54a-0c542f14db79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6536","original_object":"UniProtKB:Q6V1X1"}
{"id":"d22ff647-d161-4fb0-99bd-bd134ff050db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2637PDX9SI","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:80acb76a-766c-4195-b056-16c4059764c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:873","original_object":"UniProtKB:P30551"}
{"id":"8cf0960a-18bc-4a0a-8d12-9d0bd1abf970","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:aef1adb2-f614-46cd-88ec-070f0f755f81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q9BX84"}
{"id":"d7771563-d0fb-415c-ac18-40325cb6523b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45257132","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:a594f29b-e4da-4b3d-a64f-33da62514275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8983","original_object":"UniProtKB:P25021"}
{"id":"150ad9e1-1a31-4ad6-a177-3cab328507a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817526","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:87754ea9-4e84-473e-81c8-3121741e93ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11492","original_object":"UniProtKB:Q9HB89"}
{"id":"300122c6-b651-43aa-98bf-b7c24100b735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101913643","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:b810ef10-44d9-47b2-b76d-c85df3819362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10708","original_object":"UniProtKB:P12931"}
{"id":"a9a21643-2a15-4fbb-a4a4-09475142338a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233643","predicate":"biolink:affects","object":"NCBIGene:79813","sources":[{"id":"urn:uuid:92aac4d6-4f3d-442f-aee1-b599bf78bad3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7017","original_object":"UniProtKB:Q9H9B1"}
{"id":"d99c739a-6e1d-4fa7-8ac8-774486127b7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K9WR6LRA5D","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:ac58ffdd-576b-49c5-a7d6-e0df0f23a08a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10171","original_object":"UniProtKB:Q9NQS5"}
{"id":"cd373d79-a468-439a-8ced-2bfe98c899ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156473463","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:6c268750-119d-40b2-983d-1702d11a4ef3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13500","original_object":"UniProtKB:P15056"}
{"id":"fc9d8375-e1cc-475f-80a6-0f3fd1021637","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H84XT1COAU","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:cd3de4fb-b0d9-47cf-9855-bb69fe2edd5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1976","original_object":"UniProtKB:P21731"}
{"id":"0f5357be-e7a1-4476-9748-f6b3a9ab03a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2611","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:5e60bcb0-44fe-4584-bd4e-9eb33c9ec9d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7111","original_object":"UniProtKB:P47869"}
{"id":"cfe8ed05-95fd-4d79-a05a-573ef7bc9045","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:140675","sources":[{"id":"urn:uuid:f8fa3213-b550-4de3-9995-2841be27ac4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4192","original_object":"UniProtKB:P28471"}
{"id":"e74324ec-bf7f-49a5-b003-f937ff17e98c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656745","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:fdc95226-9ad8-48b7-99f6-e3f1f141949b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1908","original_object":"UniProtKB:Q9Z2J6"}
{"id":"1dce73f9-b032-4cc7-ad2e-0863cffe6588","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92539","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:f5e5f7f7-3c6b-4085-97d8-543099407efd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9","original_object":"UniProtKB:P23944"}
{"id":"ff71a879-b99f-4014-96b4-536bb489d3d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:82791f13-5c2f-4ad9-9e52-7819ef7013f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:A8MPY1"}
{"id":"8f5a47bf-fb08-41ed-a926-dac5f8aa98fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:856","predicate":"biolink:affects","object":"NCBIGene:1524","sources":[{"id":"urn:uuid:9b681d06-8dbc-41ad-86aa-eb55d26c20d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:856","original_object":"UniProtKB:P49238"}
{"id":"b05f9731-6ea1-4be1-92e0-da2a1a69e441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996534","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:d513e826-1c0c-4706-9895-bcac7f33ec85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10635","original_object":"UniProtKB:P00533"}
{"id":"125b2782-67ef-4756-ade0-ca9cf36a3861","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135285","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:c53557b5-7862-486e-b392-f0657122e1d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6310","original_object":"UniProtKB:Q86TI2"}
{"id":"27ef4714-bc2d-4f27-ba16-d25e8e044252","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31073","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:b64b4f74-dfa5-4528-89fd-1aa7296f240b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4264","original_object":"UniProtKB:P42262"}
{"id":"a657f29e-7ee9-4509-9dd2-899d3115e83c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:579848b0-b6c0-4533-80fd-4501b90ff032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P43116"}
{"id":"d808dac8-81e5-4c5d-abc5-8fba2bec9995","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:5774615c-dbc5-4109-88ca-08f192d2644f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P28335"}
{"id":"ea8599c1-61ef-4661-942d-f59550a5fa78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6015","predicate":"biolink:affects","object":"NCBIGene:83795","sources":[{"id":"urn:uuid:c5c4fb1f-04e0-430d-b985-af880a8bb273","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2505","original_object":"UniProtKB:Q96T55"}
{"id":"6bf9fc14-c890-489d-9baf-f44b631d012d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M3H4D91AY5","predicate":"biolink:affects","object":"NCBIGene:5478","sources":[{"id":"urn:uuid:9b2e8395-e091-44fc-bb99-9432fa08988c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11612","original_object":"UniProtKB:P62937"}
{"id":"57234595-1721-4274-937a-ae4e6f3260d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86YZ7HCC8V","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:1d499e55-9511-4c2e-9e83-42c9fe2ede1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9432","original_object":"UniProtKB:P23458"}
{"id":"3468c590-74ac-469b-b948-024d486f63dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3B512HJD65","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:b0d1fab5-ea9e-403b-96e8-bf4879ff23b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10426","original_object":"UniProtKB:P11802"}
{"id":"d2bb3436-2ee4-46dd-9734-9b3321ea843b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3713","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:b94b745a-b545-4ca7-a942-67d6ff704519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3713","original_object":"UniProtKB:Q96P65"}
{"id":"e61f51bc-0128-4d58-a9db-881be1a6ffd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17211","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:2120ed11-4353-4426-a1c1-fe048d9ffa7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3051","original_object":"UniProtKB:Q03426"}
{"id":"d9dc58b1-ac39-4da5-9d85-8a71ac0a418d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131968","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:40b59c74-fa39-4e2c-8c70-5a20938b300a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5916","original_object":"UniProtKB:P00533"}
{"id":"db594272-db19-4310-8af8-ee519181c0f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184170","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:4cc4822d-31df-4b00-a41a-7d3b8192a941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1834","original_object":"UniProtKB:P25105"}
{"id":"816a6943-f485-4306-8ef9-23f5ba33113a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7822","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:cd6164ce-6bbb-487f-be1f-0eca736e0541","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7252","original_object":"UniProtKB:P23219"}
{"id":"7706cda8-205d-49bf-bbcf-b6b0bbd773d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:c461cadb-976b-4b45-a907-1058baca1b48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:O43526"}
{"id":"21170c41-9a8a-4cc5-94f8-8d9d1cd4a6f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK43YC00I7","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:a25affe1-b81c-44ef-92cc-af8f766c32d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:183","original_object":"UniProtKB:P14842"}
{"id":"a0f34415-08eb-4dae-bf6c-db7263ea3c8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8481","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:37604e14-2edc-45a8-84c6-f801e3ac00eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:329","original_object":"UniProtKB:P08172"}
{"id":"352e82fe-b82a-434f-be9e-03f791f00034","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15552","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:a5571f2c-91c6-4389-92f4-c80a7ba6648c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1915","original_object":"UniProtKB:P43119"}
{"id":"a44dc549-92e2-4fe5-baab-928ae85e97fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RE0V0T1ES0","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:b14e6902-ca7d-485f-ac5f-7ac092413f6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12026","original_object":"UniProtKB:P10827"}
{"id":"46e5ee33-f465-4957-b82e-6ba137f20cd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85994","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:c49be1b4-286f-4d3a-a850-c523c92f0504","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7426","original_object":"UniProtKB:P35916"}
{"id":"0491defa-f11e-438b-93ea-a72bd0d441a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1471","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:d8a8dc17-6dda-4c68-8868-c728f5550fb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1471","original_object":"UniProtKB:Q9HB89"}
{"id":"9a1f6db4-1d05-42f6-9fc1-e80422e5935f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2267","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:c94fc671-3505-4b52-a22d-90bbeaf6df2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2267","original_object":"UniProtKB:P32215"}
{"id":"54b2b4aa-f894-483d-9e73-73d84fca2c5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817498","predicate":"biolink:affects","object":"NCBIGene:25153","sources":[{"id":"urn:uuid:26d190d1-6e23-4fa1-b21a-4d53976cdf8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7038","original_object":"UniProtKB:P12526"}
{"id":"14e575be-235f-498b-8351-092226304790","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73773","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:3359a8e5-ccd0-4241-8285-ece7c8459fc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1959","original_object":"UniProtKB:P43088"}
{"id":"024810f7-d48b-4e04-8dc7-b159e1122359","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8715","predicate":"biolink:affects","object":"NCBIGene:2065","sources":[{"id":"urn:uuid:bc1fc9bb-8807-443d-8b2b-bb5fffdc496d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8715","original_object":"UniProtKB:P21860"}
{"id":"7a774882-d5c2-4f34-ae2a-ae7836f2b934","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:4486","sources":[{"id":"urn:uuid:6309d876-5d32-4291-9cef-4d3e979adcaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:Q04912"}
{"id":"283fc8b9-1e82-4e90-8783-8d17bd7eb76b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38CTP01B4L","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:856c69c5-dfda-42b0-b321-bc772d378fc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9498","original_object":"UniProtKB:Q92633"}
{"id":"a23de259-98c1-4812-b994-8a283df4a331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232342","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:a02c299d-26ff-4ee6-8ee2-7bd21b1cbd69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10149","original_object":"UniProtKB:O43570"}
{"id":"86fed63b-d937-46ad-81d0-b76f57016338","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86H6B395PI","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:8bd10561-ea5a-48bf-81a0-74b09a961ac4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1218","original_object":"UniProtKB:P35367"}
{"id":"1b648b0e-a560-4f56-8be4-d20840b71281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7454","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:f4fcfe17-632b-4112-a6ff-4bb6a00131b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1663","original_object":"UniProtKB:P41145"}
{"id":"136cd1db-37b9-43a7-a766-47a2b96d3f58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:682","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:77566000-c431-45d2-bad0-7ccebd0b629a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:682","original_object":"UniProtKB:P30988"}
{"id":"6851710d-37bb-4bd0-9b4e-234a85f305ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L08J2O299M","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:34f315d8-17ff-4975-8603-6a6f32eb7adf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7794","original_object":"UniProtKB:P42338"}
{"id":"17ee09d2-9959-47c1-9332-cc14bc6be828","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755188","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:bdc8d9a2-5b2a-46e2-af80-72916626a3f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6203","original_object":"UniProtKB:Q15391"}
{"id":"f376551a-7633-491a-8f26-66d5f7ed1068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3080554","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:52141539-45cc-4564-a94d-21304e28eda4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4216","original_object":"UniProtKB:Q05586"}
{"id":"d9c644d8-e84b-4af0-bd64-c69916801087","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92869","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:9e43e2c7-7ff0-48c4-b17c-3a70ba4f1f24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3230","original_object":"UniProtKB:Q62758"}
{"id":"7d0c2513-763a-4d7c-be85-a35ccd2e17d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:b01d4a7e-002a-4ea7-af74-f27b42aaee4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P10721"}
{"id":"e981f367-8e56-4eba-9ca4-d5441bdd647e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:0127c4ca-33bc-4072-b43b-c870c52fc153","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P21917"}
{"id":"7c0a54da-c9c3-49d2-b3a7-a6c27033dacb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132316","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:afc32975-9e41-4606-8692-0741917d186f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1643","original_object":"UniProtKB:P41145"}
{"id":"4d9efa8d-3966-4154-ae6d-d33e0fda21dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27662","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:a5739cc1-772b-4a0a-bddb-22f8914ae140","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7124","original_object":"UniProtKB:P35354"}
{"id":"f4a137b9-3cfc-433b-b70c-f859d77a3b2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:65e57dc9-9961-4891-b736-265411a778d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P30939"}
{"id":"c5287be5-be9c-40bc-a461-1228cda93e98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46203026","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:e92f2f15-4709-4f23-9785-0d7dd78e22cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5814","original_object":"UniProtKB:Q6W5P4"}
{"id":"cf608499-4453-4f4e-8c41-3bcfa9540988","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1320","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:38368801-3cb5-45e9-bcf2-52a1073f9a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1320","original_object":"UniProtKB:Q01726"}
{"id":"2ee63198-3dda-4ea2-92a2-988c3a8804b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755254","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:07c9f83f-fe72-4ee5-a5c2-ea50c8824c7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6992","original_object":"UniProtKB:Q9H228"}
{"id":"59ffae6e-f688-4964-9605-4c3666425fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169423594","predicate":"biolink:affects","object":"NCBIGene:7097","sources":[{"id":"urn:uuid:437c1678-258e-4666-b9ba-e9f20447e585","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8888","original_object":"UniProtKB:O60603"}
{"id":"48486457-5f66-48ba-b970-4bb53bdc6254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4012","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:76b69940-9187-43fd-8d79-99a31c37c2df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4012","original_object":"UniProtKB:Q969F8"}
{"id":"8e6682f9-5dd6-46ed-abd6-3793aa2ed27d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92845","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:e5f6d32d-8fc9-4507-90ac-8b98ae9eaf37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2429","original_object":"UniProtKB:Q8R455"}
{"id":"d58c29b2-88f2-49bc-b775-3fdcf1371a18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8252","predicate":"biolink:affects","object":"NCBIGene:1048","sources":[{"id":"urn:uuid:f0d0c998-a51b-40ac-b765-706a097287ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8252","original_object":"UniProtKB:P06731"}
{"id":"aa2e48ce-bb33-4875-acf8-f52d13264e49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91361","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:edcb1de9-e739-41d5-b167-54f138509cf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8010","original_object":"UniProtKB:P78527"}
{"id":"790fd0c0-9c8a-42bd-9ae4-7012facddb33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:441P620G3P","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:31604dbe-2278-42cd-91a3-f27f5bf8c3dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9426","original_object":"UniProtKB:Q9BY41"}
{"id":"cf86f9f8-fffe-49d7-9f18-bd801d03b182","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2547","predicate":"biolink:affects","object":"NCBIGene:24520","sources":[{"id":"urn:uuid:89bb29b9-50c2-4a16-b8c4-2e3cfed84c60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2547","original_object":"UniProtKB:P10499"}
{"id":"4e091ffb-7eb6-45c5-8dcd-79c8b4280592","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92149","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:0a485f9f-9554-424b-8af3-348d351bebeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7381","original_object":"UniProtKB:P35348"}
{"id":"ddb42397-a5f2-4ee9-a593-fe7fa7c93e4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2947","predicate":"biolink:affects","object":"NCBIGene:14366","sources":[{"id":"urn:uuid:5cd5ccee-46c2-4ae6-b528-bb32548b9a2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2947","original_object":"UniProtKB:Q61088"}
{"id":"18ab5855-a677-4b37-9201-8d61f2c68b28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:635","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:4d338468-0536-429f-99ee-e515af1fa1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:635","original_object":"UniProtKB:P24053"}
{"id":"bf21af4f-00f4-424b-b0df-97f3e8c83991","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L348DM9HQ","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:2a5ef8c0-16ba-434b-bdd5-40d63f81f9a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2981","original_object":"UniProtKB:P51639"}
{"id":"17d4ceea-5392-462d-b944-aeebb297b486","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2612","predicate":"biolink:affects","object":"NCBIGene:81033","sources":[{"id":"urn:uuid:c2de8e8b-a91e-4a69-807e-519f2d0b7c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2612","original_object":"UniProtKB:Q9H252"}
{"id":"3c1da976-3195-4859-9220-704f327fc2f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"UniProtKB:O54898","sources":[{"id":"urn:uuid:4ddbe1ba-2f46-49b3-95d7-64e05e5404ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:O54898"}
{"id":"a4b83d0b-be42-4bca-aa0f-54514b4df76b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:3194ef4f-579f-4d32-8923-6b70608c3a4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:P42336"}
{"id":"dea2f0ff-2b0d-4476-a37d-f22220000a75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124226","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:a224dea9-8a45-46bc-acf7-dcc06744d36b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:322","original_object":"UniProtKB:P08172"}
{"id":"2245e62f-2a7f-4e9c-b15a-f623d6b7dd76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:79489103-286e-44a7-ad7d-0ee489dd0223","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:P52333"}
{"id":"b8bbcb96-c0cc-45aa-a3ef-825ff4f98e94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:08WG8S0L8D","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:9cff5f4d-109f-4591-8fbf-d2a1ea46f569","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8913","original_object":"UniProtKB:P08581"}
{"id":"5c0fac4f-b9f0-4ecb-8302-12ba7f7558a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:f608897f-6d7f-4597-9afd-d678e9168437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P10721"}
{"id":"d34157ac-8bae-4877-8181-bdc5a08e8e6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:5311","sources":[{"id":"urn:uuid:d7663200-1d0c-4ada-89ff-7bb5b577ed3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q13563"}
{"id":"711eb44b-bbbb-4b3b-baa9-a3e1af75ab31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95255","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:1101ab86-8105-46ff-aa69-4239d8e4ee4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12433","original_object":"UniProtKB:P59540"}
{"id":"278ed373-0e54-446d-9bea-4baeb149f22b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45716","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:3a69070d-4b43-4f6c-bd6f-7fa4a5d16844","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6852","original_object":"UniProtKB:Q969S8"}
{"id":"725ae0fb-5d5d-4ede-a84c-b089d40b8cf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:c7ce82e5-b3a4-46a2-86bc-8814f3686c5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:O00222"}
{"id":"9e1bfb99-eecd-427e-91cb-53eb32cf126a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6965","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:093792a5-0a5b-47ca-b770-62cfb47fc722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:207","original_object":"UniProtKB:P28223"}
{"id":"21009df1-07b7-4495-aa3f-3ba7f998d292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2706","sources":[{"id":"urn:uuid:f7fd1297-42d0-4a2d-9753-e1495564aaf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:P29033"}
{"id":"680f252c-f428-4995-8ae1-80d5ed5ad132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73357","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:423ab5bb-9fcd-477a-b129-244d5b2b19b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1656","original_object":"UniProtKB:P41145"}
{"id":"7460f7a9-2c9d-4a24-802f-61e38de778cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"UniProtKB:Q61618","sources":[{"id":"urn:uuid:cafb2611-d1a1-4eb1-a51d-98725b7ae410","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:Q61618"}
{"id":"6cb36aba-0dbc-49aa-9427-e649d88aad63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56929299","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:9c6ca48a-a619-4afd-a349-7b851322c40a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6368","original_object":"UniProtKB:Q8R455"}
{"id":"d1657be8-7c87-49a2-89a4-b899e6bea2e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FOF5155FMZ","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:bcd8bcff-f9aa-4309-a16b-f72cc9d05b22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9563","original_object":"UniProtKB:P48736"}
{"id":"119a81b6-4e9d-41f8-989f-e4407c49933c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10458325","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:7008973a-fd12-422c-9088-1ead35404386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7944","original_object":"UniProtKB:P35968"}
{"id":"43d1cb01-52b1-4501-8b1b-bda74bc9f276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:332da797-df73-4c5f-938b-6614d1bfd53b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:P35408"}
{"id":"39da32a1-2c03-4dee-aca8-a7e1448f9d6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137029447","predicate":"biolink:affects","object":"NCBIGene:6597","sources":[{"id":"urn:uuid:074ec590-4a3e-4a08-b073-7a579f7019bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12206","original_object":"UniProtKB:P51532"}
{"id":"a0cddda2-d2c1-4910-988a-87dc51aa4033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2315","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:55235498-2e5b-4be2-b63c-178c72b577f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2315","original_object":"UniProtKB:Q9H2S1"}
{"id":"88b35c34-b547-48ec-b9a0-ed2624652f31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:42EK42WHI5","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:739df789-94bd-484e-a72e-877bf3883e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9620","original_object":"UniProtKB:Q13627"}
{"id":"c37b7afb-1f79-43aa-92c9-a44477fb312c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3649","predicate":"biolink:affects","object":"NCBIGene:2826","sources":[{"id":"urn:uuid:70edf957-f00c-4992-abb6-5ae55e359cae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3649","original_object":"UniProtKB:P46092"}
{"id":"ca391664-6cd0-477b-a0c5-7b2de6bfe605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166633833","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:fda4c8a2-5631-4c9c-a530-423db99b9a6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12439","original_object":"UniProtKB:O43614"}
{"id":"af7c8e40-47ca-4aa0-9316-f00ec41515dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:610ec7f2-3a23-40c0-a398-69b656748f8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:P30542"}
{"id":"8963287b-e9d0-4400-aa4a-89bac58938f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135260636","predicate":"biolink:affects","object":"NCBIGene:10724","sources":[{"id":"urn:uuid:b1990132-53b6-45b8-b808-189d15d3d8c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11953","original_object":"UniProtKB:O60502"}
{"id":"2c38a1a2-7928-4d85-9593-31d793c1b415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FM7JG3L4SR","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:1f244024-df9b-4aac-b55f-51d73acb228f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9263","original_object":"UniProtKB:Q06187"}
{"id":"e6071ddc-a62d-46e8-ae13-d6834d29a836","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3603","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:d91db5fc-93d2-409e-9cdc-571c56f50601","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:308","original_object":"UniProtKB:P08173"}
{"id":"d7dbd339-1fad-4509-a078-973575e8e10e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:633","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:1feac5ca-ae63-45e4-9ff8-1c9689ac8b30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:633","original_object":"UniProtKB:P32247"}
{"id":"eb342544-5ba0-47a3-8ac6-80873a1f89c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197437","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:c034bfc7-19c5-48af-9532-b203a5fbc31e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7008","original_object":"UniProtKB:Q92769"}
{"id":"ca9a91d3-51e2-46de-ab61-5e4a9be8cf63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864283","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:58964fec-9890-40bd-ad5b-761b32396787","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8209","original_object":"UniProtKB:O75116"}
{"id":"d87f31ac-a428-4ea6-8870-d92841dca4ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8B97A88D35","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:9d306d10-7876-4dee-ad0e-9e31aeac82c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8915","original_object":"UniProtKB:P48736"}
{"id":"cdc39fe9-b50b-4893-86d4-d51eb0d1e776","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10587912","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:6cb67868-6104-4eb6-a274-0a25ab55c900","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:545","original_object":"UniProtKB:P07550"}
{"id":"77d3887d-2034-48a3-8ea2-938f19c1fa6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31515","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:ed99fa8d-06b8-471f-b2fc-dc3c2e04b7b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:965","original_object":"UniProtKB:P35462"}
{"id":"1a9e39a1-41d2-4067-8ec9-0c1d17b49456","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40139","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:37efbc10-9871-4fa0-a5ed-d4d67deb533b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1392","original_object":"UniProtKB:Q14832"}
{"id":"2546f31e-70c5-4548-a217-72c7df8da718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17737","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:dbc503d2-2db9-4439-ab21-0a6d712f891f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2748","original_object":"UniProtKB:P55055"}
{"id":"8545ba39-b291-42e6-bfac-dcc1e3484804","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ELK3V90G6C","predicate":"biolink:affects","object":"NCBIGene:914","sources":[{"id":"urn:uuid:3ca685d4-ebb8-4850-831e-88ca3839c070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6787","original_object":"UniProtKB:P06729"}
{"id":"fad38b9b-9b68-4d49-b507-8aebf4d87600","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16730275","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:e483a7e7-8c0d-4ed3-a32b-45d0f9d54496","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8761","original_object":"UniProtKB:O14684"}
{"id":"5cb3a63a-5115-4267-ae08-58d399282d48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166221107","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:57d6e6c5-7677-4f96-a9df-b4b16cdcf897","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12739","original_object":"UniProtKB:P0DTD8"}
{"id":"a9b2c7ab-80e5-4f0d-8de6-1dac3d9a979d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13661","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:6db01b88-7116-4ac4-83de-bd886d70bd61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13661","original_object":"UniProtKB:P08684"}
{"id":"43f6a0ba-26c2-44d7-ba69-fd54acf1c266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2093","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:3c679722-b066-453a-9379-5ad7cf074b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2093","original_object":"UniProtKB:P25103"}
{"id":"1585cdc1-cddd-4b35-b0a6-ae9c3298a277","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114187","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:55cb9ba2-4c26-4289-bc6e-6ad0832f0bcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9002","original_object":"UniProtKB:P35372"}
{"id":"110d2eae-237a-45b7-9c0a-e32572818932","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:0de832ce-241e-4dd6-8607-f5c0aa1fee31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P50406"}
{"id":"a201c9c1-9325-4d22-abbc-0b091e63d5bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33569","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:cd1543b5-92e6-4307-80d2-51432b16d96b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:484","original_object":"UniProtKB:P08588"}
{"id":"5ebb678b-cdff-43db-bb02-67dffcef5fc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3645780","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:94b3a1bc-5ed2-4683-8c8e-00e779cb75ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1417","original_object":"UniProtKB:P41594"}
{"id":"d7659345-db9b-41d1-bd98-f6869ce57ead","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138628908","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:b199aac1-273a-42e2-9f2d-db8deb1de6ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11888","original_object":"UniProtKB:P36897"}
{"id":"fd1a925a-af7f-4cd5-bcf4-3fad6ae7805b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30813","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:8cf6d76c-10fa-4fff-b66f-bfba20a4f33c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5532","original_object":"UniProtKB:Q9NQS5"}
{"id":"cb332664-276b-457e-a380-a61c3aba9f77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755172","predicate":"biolink:affects","object":"NCBIGene:24816","sources":[{"id":"urn:uuid:82441d69-c004-4641-92c8-e140eb5a2b0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6070","original_object":"UniProtKB:P34978"}
{"id":"4cfe38db-278d-4d4d-8e80-4857979beb90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422747","predicate":"biolink:affects","object":"NCBIGene:2857","sources":[{"id":"urn:uuid:4bcc074f-2e53-46a1-955a-b23d4da49dd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12947","original_object":"UniProtKB:Q9UPC5"}
{"id":"4de59b29-f4fe-45b4-aafb-7c573f352c8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"NCBIGene:1135","sources":[{"id":"urn:uuid:def4ee45-ff19-4684-a8d9-8711f4288d8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3976","original_object":"UniProtKB:Q15822"}
{"id":"3750dffa-9a64-4aec-acf8-d137c5e543bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:43J9Q56T3W","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:6ce60f0d-33ad-42d3-a38d-f61680f8cc54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8969","original_object":"UniProtKB:P48736"}
{"id":"46589589-9586-4484-bdb5-fa0f99b0a542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147075611","predicate":"biolink:affects","object":"NCBIGene:20273","sources":[{"id":"urn:uuid:947d5f67-fcb4-4085-8032-951934998151","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12643","original_object":"UniProtKB:Q9WTU3"}
{"id":"41ae7bac-6862-42d9-a0be-90989a180df9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66561876","predicate":"biolink:affects","object":"NCBIGene:1511","sources":[{"id":"urn:uuid:3ae6a661-55ce-4869-a167-33a6141e7341","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8626","original_object":"UniProtKB:P08311"}
{"id":"8590619c-d737-4767-aa40-8e507ec141aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:03S640ADSK","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:66328822-315a-43e9-9c3e-cc150b59dc50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11818","original_object":"UniProtKB:P20272"}
{"id":"4643cf58-67fd-469f-88c4-785c3b912ce5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50841","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:e27bb2e4-a2ca-4f1e-b98c-f24687d5743f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:205","original_object":"UniProtKB:P32305"}
{"id":"9ff8a4a9-cee3-4149-bf54-cfbb1c411c65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16422","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:71710117-5e7f-4fe5-b719-e7ca104b43dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2860","original_object":"UniProtKB:P15207"}
{"id":"6acb15b2-a98c-451e-890d-cdc33d290d3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167670","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:36671a5c-ee46-44b4-8006-b98374e027ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8056","original_object":"UniProtKB:P28482"}
{"id":"70b81ce7-a262-4d81-a521-255280a90fd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:158617","predicate":"biolink:affects","object":"NCBIGene:682930","sources":[{"id":"urn:uuid:9990937a-07c7-4f12-9c6b-f9949546dc4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2513","original_object":"UniProtKB:Q02485"}
{"id":"741f4463-f6ba-4467-aeab-24341d5ba231","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1021","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:f81e7252-362c-4122-bf7b-0efe7d973819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1021","original_object":"UniProtKB:P21462"}
{"id":"68da5b5b-d3f4-4668-a4a3-024bcb43aca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:c70cd45e-8cfa-423c-99c2-1213e8809989","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P28222"}
{"id":"29b9cc84-a021-47b4-9f99-0f3b12cedb9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:ec49be52-37c1-4fa8-ad2a-7b9258e5dd1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:Q96GD4"}
{"id":"28fbe7b7-847b-4ab8-9bc8-e82673c65107","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817389","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:cc7458f5-933f-43e5-b8ac-93c0c53172f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1128","original_object":"UniProtKB:P43219"}
{"id":"2bb07848-f8cb-4d4d-ae30-942dbd0c7d5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9086","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:de1705c4-bf1f-4141-a55d-dfbb8b749753","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6639","original_object":"UniProtKB:P27338"}
{"id":"e7e4b85e-309c-4f2a-b54f-d0045292c734","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4894","predicate":"biolink:affects","object":"NCBIGene:5618","sources":[{"id":"urn:uuid:b3b800c8-975d-4aab-b930-b0c2fd68d229","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4894","original_object":"UniProtKB:P16471"}
{"id":"93619b2b-9d56-4b63-9de5-209f9415fe7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K41YC3AEI8","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:95fc30e5-bfb9-45d6-af8f-860f44a0ab7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1622","original_object":"UniProtKB:P41145"}
{"id":"d4117eb8-e77a-413d-af33-696eb8685d09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124226","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:944a1d16-ca1f-4873-80ec-5235f6579c0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:322","original_object":"UniProtKB:P20309"}
{"id":"0e8a1d19-fcfb-4262-b860-588a57aa2cb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136218973","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:66590ce7-868a-4f5e-a579-86bb885a7247","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5590","original_object":"UniProtKB:P0DMS8"}
{"id":"d95fe00e-b7bc-4b0f-a1df-445b8680cb51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11332190","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:aa605e5e-cbe9-4fcb-a119-3ab9a0be45d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3422","original_object":"UniProtKB:Q99788"}
{"id":"a4146f7b-6b41-4836-8e10-69bebeed6bfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OE1QTY7C25","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:cd4f13a3-4a60-46e7-a027-d2b1b1f8fadd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10631","original_object":"UniProtKB:O60674"}
{"id":"6e54a459-a278-427c-aa4d-04f8cc2fc6ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15293210","predicate":"biolink:affects","object":"NCBIGene:6096","sources":[{"id":"urn:uuid:86deb972-77ea-40bf-8a53-f08df9430d3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8906","original_object":"UniProtKB:Q92753"}
{"id":"03b77936-6b60-410c-ac06-d605eec0c446","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:165301","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:f95b0597-846f-4952-9ec1-ecc6281712cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1945","original_object":"UniProtKB:P43114"}
{"id":"839fd478-c1f8-4206-88e8-212b9bac79d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146472812","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:a114f6fd-331c-4e5d-a3d2-dddd6bb46ecc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12066","original_object":"UniProtKB:P01116"}
{"id":"6bb26fb0-bda1-4dfd-8f29-97cd41deb9a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65353","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:af318aa8-8c8c-483f-81f2-649c95b2c568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2941","original_object":"UniProtKB:P28223"}
{"id":"b892c99c-8520-49d1-a998-66c241059108","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34823","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:607cf16f-3a17-493b-be3e-44820d1fde8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2599","original_object":"UniProtKB:P56696"}
{"id":"fc7bc816-e359-4803-b541-7a61a1f332c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:0929d3ff-c4d0-4525-a173-c8fea539b300","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P35368"}
{"id":"2749fd79-fa0f-450d-be90-23b4bd848f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3698","predicate":"biolink:affects","object":"NCBIGene:55366","sources":[{"id":"urn:uuid:8ce61921-eaf4-4557-a63a-08285409bdc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3698","original_object":"UniProtKB:Q9BXB1"}
{"id":"d1ada073-043e-46ff-bfc0-4f4c341a7fd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D9Q2QUU75","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:6633dce9-d41c-476f-8685-9cd5beeada18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:474","original_object":"UniProtKB:Q60614"}
{"id":"9b35c5ca-fcfd-4a0d-a7b3-d8f970d34e9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:ff89843e-1804-4878-962b-c207011ccb5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P30939"}
{"id":"414b8908-6c67-4cbf-bbca-1da09831fdf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321959","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:cb31c599-e627-430e-bdda-1b62722a2122","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:131","original_object":"UniProtKB:P28221"}
{"id":"d7cc2ed1-7e57-4627-846d-271055e1ee56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:d64fba04-9727-403e-9187-5b8ec4896e1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P21728"}
{"id":"8c0bf0c5-dc35-48e9-ad54-512ad3f22c91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310992","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:67f0acac-325d-4449-bcf2-bd6b50a232ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:416","original_object":"UniProtKB:P0DMS8"}
{"id":"15b8c208-08af-49e3-811e-24db5b9fbd50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081963","predicate":"biolink:affects","object":"NCBIGene:12767","sources":[{"id":"urn:uuid:4ed971cf-ddd6-42e0-911e-4c01d8b669d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9883","original_object":"UniProtKB:P70658"}
{"id":"a0b3a9fe-e587-4e3c-8315-55ba09255628","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132178569","predicate":"biolink:affects","object":"NCBIGene:9706","sources":[{"id":"urn:uuid:534a2846-033f-43f2-85fc-a26f2c731107","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11340","original_object":"UniProtKB:Q8IYT8"}
{"id":"86ac01f5-6fb9-4cfd-9457-3f7d7a05e655","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46225540","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:d916a47e-d7e4-4ba7-9eb7-a24e85dc4ba0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8181","original_object":"UniProtKB:Q9Y243"}
{"id":"578dee82-0624-4152-99ce-6e07c4ef802b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S173RED00L","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:ad2c2333-0a9e-4e76-9e94-c05ef4c3d1ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10732","original_object":"UniProtKB:O15393"}
{"id":"2444f1f6-58d3-4647-9395-c9d761cd3907","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231351","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:bb0d9d7d-2ec2-4c1f-b029-8313ece07da3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10476","original_object":"UniProtKB:P35968"}
{"id":"09ca6331-dd68-42db-8420-191d9c109af9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190024","predicate":"biolink:affects","object":"NCBIGene:23569","sources":[{"id":"urn:uuid:e72e311e-4b0e-482c-ac5f-a74017c89097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8685","original_object":"UniProtKB:Q9UM07"}
{"id":"fb16962d-de55-4f62-a072-f2f394a532ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:339BU4Y35U","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:c343c528-4680-4a06-9486-d4f0609c6317","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8724","original_object":"UniProtKB:P49798"}
{"id":"1afbe5df-ac6e-456b-b82d-6bda85912b9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5812","predicate":"biolink:affects","object":"UniProtKB:P0C0L6","sources":[{"id":"urn:uuid:b15808cc-c9f0-47ea-b78f-83bbff5353ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5812","original_object":"UniProtKB:P0C0L6"}
{"id":"facf797f-5f91-4c18-a3e8-d358220eace4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134726","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:bfbe11ff-fda7-476f-be54-2b37ed1ee350","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5608","original_object":"UniProtKB:P30543"}
{"id":"d0ef08ba-fa8e-4159-9979-d0a5845462f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2003","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:be41b77e-cc3c-4002-9d9c-be18a61bf554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2003","original_object":"UniProtKB:P32745"}
{"id":"4fa595ae-466c-4a59-93bd-5ac6d30e8ddf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79990","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:e14959b8-9bc0-4568-90f2-920a164a02ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2656","original_object":"UniProtKB:P37231"}
{"id":"11804ea6-58cc-41a6-9ca2-23f456c43788","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X59W6980E8","predicate":"biolink:affects","object":"NCBIGene:2645","sources":[{"id":"urn:uuid:164af595-ee8c-4be4-869a-45a7538894a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12124","original_object":"UniProtKB:P35557"}
{"id":"acc46d28-1b19-4b80-ba60-771f4c54dba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:670","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:86608478-6a86-43a6-9b3e-8c88af6f3739","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:670","original_object":"UniProtKB:P30411"}
{"id":"69cdfdb7-be64-4503-b9bc-3c1185b389a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11291932","predicate":"biolink:affects","object":"NCBIGene:10039","sources":[{"id":"urn:uuid:c5dcb84c-0a68-4553-83f6-bc2cfd1e4f9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13125","original_object":"UniProtKB:Q9Y6F1"}
{"id":"00e45679-4359-40e5-a3de-1a5a2f42269c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2064","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:6a247a09-10cf-4ba1-a8ee-af1091947391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2064","original_object":"UniProtKB:P30874"}
{"id":"aa8fc67f-7630-4eed-9a1b-44c8bc618e43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43876","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:6b6d4a70-4b25-4f2a-b692-345f9ce04b66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1373","original_object":"UniProtKB:Q14831"}
{"id":"e062d520-2aff-4245-b477-15d8479040ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54765113","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:ea15f557-0567-4bc0-bdef-9606ceae9138","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9122","original_object":"UniProtKB:O43613"}
{"id":"a7eeb098-34ff-46ac-a387-827244190822","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52392","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:32566747-f3b5-439d-adcf-1b2a5dc9aeb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:729","original_object":"UniProtKB:P34972"}
{"id":"b75b274c-c429-4e7a-9a60-b7c8588205ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27960","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:4c1497d1-bd3a-422b-9749-e65d6340539b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8759","original_object":"UniProtKB:P35228"}
{"id":"5751cc06-3bfc-4362-8021-3ab7ff507a98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61400","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:330b3777-c8a5-481f-b23e-efea15f489e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9176","original_object":"UniProtKB:O60285"}
{"id":"18e2422e-c11a-45c8-9b2f-7b9ec7ec1032","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75124304","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:da41521c-e202-4c9c-ac8b-725087e64d2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7521","original_object":"UniProtKB:O60885"}
{"id":"1e7b1299-6363-4927-81f2-89da77e07fe4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3112","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:32f96a88-6aae-420a-b547-490b3329a018","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7128","original_object":"UniProtKB:P08173"}
{"id":"c52e1127-cb79-44b9-9b1f-c04c99e3aa5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:37b9e03a-fd7a-4055-9138-4b85e74f454d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P35367"}
{"id":"7e2c7473-8cc5-4ecb-8fa4-d2ce6fb7d595","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:2f2ed677-a52c-488c-98f3-0570b9253965","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:Q9BY41"}
{"id":"18457bc3-5246-4e6d-b19c-fac6eb2f319d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92341","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:33d0531e-4b7e-44b6-8c6e-a86fd5f58842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:15","original_object":"UniProtKB:P28222"}
{"id":"b24fdee2-45dd-4968-827a-93dd393cfb79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93432","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:2823ab54-74ef-439e-9ba4-2e4d88823519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8584","original_object":"UniProtKB:P08912"}
{"id":"65b00727-2392-4763-98e2-3165d9eab833","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:99890468-9725-42fb-ada1-b50ac88efaa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P47869"}
{"id":"09dcee89-e0ce-4a1e-8643-f8a9989958ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134846","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:65c6e38f-dec7-4f52-9505-7cb0afc835ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:306","original_object":"UniProtKB:P08912"}
{"id":"5326395c-c11b-4059-a687-aaf7e4876143","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:71f8570a-2304-46d8-bf7a-3f75d00bc6e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P21728"}
{"id":"db1c7d97-60d8-4472-9b49-da755f2caef7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3644637","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:e2715793-188d-41d7-8412-04708f309c60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:193","original_object":"UniProtKB:P41595"}
{"id":"479b59ab-aee8-4288-a012-61cb3e27ee34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8776","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:a4b61823-32e2-4021-800e-3f8fcac7afcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1234","original_object":"UniProtKB:P25021"}
{"id":"df64da69-669e-4639-bfe7-3b00ebd99274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44589122","predicate":"biolink:affects","object":"NCBIGene:14073","sources":[{"id":"urn:uuid:ab3de73e-2b42-4e5a-b41e-f1884ee7b905","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11815","original_object":"UniProtKB:O08914"}
{"id":"adca9956-e78f-4d1f-a3f4-837f790139a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:19887410-9016-427b-939f-80d7bad5e94c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:P25102"}
{"id":"7b6775c9-4f1b-4e85-8356-0bf8dfa34cc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801483","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:84f9de0c-214b-4b85-8911-3b7e60fb50a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10547","original_object":"UniProtKB:P06493"}
{"id":"f2f4af83-660f-486d-92b3-6cb31d5324d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75728","predicate":"biolink:affects","object":"NCBIGene:22064","sources":[{"id":"urn:uuid:e782031c-10c4-4d93-b006-63e0ebf4869e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2437","original_object":"UniProtKB:Q9R244"}
{"id":"78f6410f-331d-415c-82a4-571fc5a9e433","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9935175","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:36171192-04c5-4c90-a2e0-597dbc547784","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:880","original_object":"UniProtKB:P30551"}
{"id":"7e430d5d-526b-4560-91b8-a2fc89dc8e8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91460","predicate":"biolink:affects","object":"NCBIGene:12322","sources":[{"id":"urn:uuid:1bd84ab2-acf7-4b06-a288-e34f65605b72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6002","original_object":"UniProtKB:P11798"}
{"id":"f6a1ade5-04aa-44bb-8b3c-741923bbf1a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167176","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:5567373e-0754-430f-9df5-8730c2b670f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11078","original_object":"UniProtKB:P0DTC1"}
{"id":"cb970139-af33-4dc1-bcc5-434f36d4212d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135769","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:09149a02-576f-412e-9143-cf2571523975","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7557","original_object":"UniProtKB:P14416"}
{"id":"80b0b516-9061-4665-8a23-94f886f772c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:3137a8aa-a053-49b6-a936-f8a467595306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:Q16620"}
{"id":"a6cd9f21-0fcd-45ba-a933-f88e2f0e49a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:86714802-3a32-41e2-9536-bde3bee7af9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P41595"}
{"id":"a8f67a0e-080f-4445-a0fe-b04afe2cfb5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44391713","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:ed621cbe-4d99-4e12-bf9e-80f5a5f2e1b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:252","original_object":"UniProtKB:P97288"}
{"id":"d2ca1180-7438-4826-ba51-24660f055094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31296","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:3c46dbb7-7d60-46e7-98d8-71133b3b2386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7670","original_object":"UniProtKB:P28223"}
{"id":"4b227311-dfbb-4893-9716-efbd01c66f7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146188223","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:33cc6b35-0724-42e8-9d1f-7eaa084d0c34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13359","original_object":"UniProtKB:Q8TDS4"}
{"id":"b578f009-4cbe-47e7-a981-43dd51ebc717","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232494","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:748447b6-1b6b-4fa4-ade8-615e0dcd8bc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4232","original_object":"UniProtKB:Q9UL62"}
{"id":"d93cc24f-e1ec-4c5c-b24b-d1e71bc0bb0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:922","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:8ecf4b78-e39e-4903-8e52-0a27a00b7134","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:922","original_object":"UniProtKB:P34998"}
{"id":"b0f7caed-6bc2-4a27-ae5e-f69689cb5444","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3892","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:415e2a2f-f76f-4bd9-af22-dd422f8407f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3633","original_object":"UniProtKB:P32245"}
{"id":"aa460dd3-1adf-424c-9702-72e96453dd5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993666","predicate":"biolink:affects","object":"NCBIGene:2288","sources":[{"id":"urn:uuid:427ad972-6560-418f-86d0-dd5b3c14c9f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12610","original_object":"UniProtKB:Q02790"}
{"id":"b3c84ceb-b357-423e-bf21-3c0526e1fb2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7465","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:737af344-bd7b-4f4c-8254-14d642554498","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1639","original_object":"UniProtKB:P32300"}
{"id":"d186df0d-2b84-4349-a653-d1b711af2d70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754996","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:05122b82-aa99-4ba6-9396-964b9641b0c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:562","original_object":"UniProtKB:P25962"}
{"id":"d13dc06f-0e33-4b12-8cc1-38777c2848e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9HGW1H8S2M","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:7bcae542-d53a-4acb-a846-62ec88e60b85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10242","original_object":"UniProtKB:P35354"}
{"id":"f8545e4d-7971-43b9-951f-2ad77a13ce47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73670548","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:31f2438f-4ef7-40dd-bcd6-20db9b4bb808","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9273","original_object":"UniProtKB:Q15910"}
{"id":"7f84d82f-ac81-4347-99fa-470683102e92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600315","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:582d4890-ebd2-4b2e-86bf-41b3cf404186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10688","original_object":"UniProtKB:Q13627"}
{"id":"6160f2b8-a905-4b0e-96b7-52723cff371f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11849514","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:2da68de3-89e0-46da-8552-ebd491c96c3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:714","original_object":"UniProtKB:P41180"}
{"id":"2b1b8e88-9d06-4a9a-8210-07610dd8d34a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:640f041b-423a-4fa4-bef6-8358d0712bfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:P13569"}
{"id":"ec24a2cd-9817-436d-b854-2a6a6568049f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8ad51668-3284-4be1-a81e-3772c51ca2f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P08173"}
{"id":"51e2c162-2bfe-4cc6-9864-539507124bd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75593419","predicate":"biolink:affects","object":"NCBIGene:5046","sources":[{"id":"urn:uuid:753e06d5-74be-480f-beba-40fc4d932b45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8658","original_object":"UniProtKB:P29122"}
{"id":"36e7df80-76d9-4360-a064-bd6d9d7d49d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:8e22d49e-744d-4b09-ac71-258265d4c085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P14842"}
{"id":"0c1b9adc-95c1-4a7f-ad3c-76489760b319","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:00M5444DIY","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:ae9b1d12-ecbe-4a77-a292-7c86b41e750b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1691","original_object":"UniProtKB:P41146"}
{"id":"7fda93e5-f6e1-4a02-ad55-002059202290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:961a7d54-5bc3-4e27-b52a-fa156d66705e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P08912"}
{"id":"2f9f29ee-0914-4a11-ab72-58612f5d625b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132220479","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:6baa1966-fca8-44da-8972-e1d0ec95308b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10001","original_object":"UniProtKB:P42336"}
{"id":"8d8ea285-ad13-46df-a52f-97ebf32c786a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9864550","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:b0450b56-4825-4e9a-a00f-20e6a1a62671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4332","original_object":"UniProtKB:Q12879"}
{"id":"5c49026f-1993-4172-956d-6092a4785ec7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:2700","sources":[{"id":"urn:uuid:57bd5320-094e-4524-bb21-0b695d9689f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9Y6H8"}
{"id":"9ce8a091-8d37-40e9-a027-6cd996235d81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3699","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:411f4d46-b0f2-4849-9d04-5b2732e9b700","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1231","original_object":"UniProtKB:Q7RTT9"}
{"id":"c8bbfee9-a734-4945-8b4a-674cc543fb85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54670056","predicate":"biolink:affects","object":"NCBIGene:5547","sources":[{"id":"urn:uuid:23c22c93-7b80-43b2-9525-bac5e1b88141","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8554","original_object":"UniProtKB:P42785"}
{"id":"e3d6cea6-280a-4319-8c2c-ed3c2d7ef6ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3176","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:e0ce2a8e-227d-4522-bdcd-72e6a16a50ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6797","original_object":"UniProtKB:P00915"}
{"id":"56106883-218d-4114-90af-bcafda0c6eec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755180","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:54e544d8-371d-49da-b47a-2b5b65e9bc88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6176","original_object":"UniProtKB:P30550"}
{"id":"b26aeb41-aec0-49be-85ed-210cdac1d9ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232982","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:723762b2-18f7-4874-9aa8-f5679fe7390f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:188","original_object":"UniProtKB:P28223"}
{"id":"0513d3ab-7884-4f78-b520-13520f97f7c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:4d4b5dd8-1bb1-447f-9acd-5820a89e920b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:Q15303"}
{"id":"d3b74eba-d63b-46d0-8279-ed2df169b194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31448","predicate":"biolink:affects","object":"NCBIGene:6559","sources":[{"id":"urn:uuid:8abb6df8-23a8-409c-b13c-815572630750","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4167","original_object":"UniProtKB:P55017"}
{"id":"15fbbbc6-6a2d-465e-a5e9-e95bcbc44be7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14229352","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:7d7fc3ce-ce38-4868-a0b8-2fcd41c83e21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2966","original_object":"UniProtKB:P51639"}
{"id":"986781b3-3677-48e3-9b2e-c5d86a00135e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321166","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:f89ceade-e39b-4a24-9f90-60e8fea08a72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10186","original_object":"UniProtKB:P19793"}
{"id":"ba5ea05d-3d67-4946-8da2-39e115e7daa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24937012","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:8d0332c4-fdca-4334-b6c4-95471cdc4fea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8242","original_object":"UniProtKB:O00329"}
{"id":"2636b6a2-3030-4d70-b82a-c95bbbafb5df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3897","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:8fc6f52a-1a69-4640-921d-6e8ba9466e95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3897","original_object":"UniProtKB:O08726"}
{"id":"be8262c5-88ac-453a-8d31-936c319d2d2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13544016","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:71ea5115-b656-425b-8803-655a4a1eb7a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9282","original_object":"UniProtKB:P33535"}
{"id":"19f0150d-122e-499f-a6d1-bd4c9f34b13f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17941505","predicate":"biolink:affects","object":"NCBIGene:5603","sources":[{"id":"urn:uuid:7d7b38ea-e2c6-459d-ad13-1e8a60d71108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11096","original_object":"UniProtKB:O15264"}
{"id":"07573024-6228-4d69-9dd2-00a42c46e93d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11898","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:b7e1d548-6faf-4bed-b4a2-6e8aad6715cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11898","original_object":"UniProtKB:Q9HBX9"}
{"id":"db2ea696-dfa1-4e39-acfe-6042d8474ffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230819","predicate":"biolink:affects","object":"NCBIGene:6506","sources":[{"id":"urn:uuid:fbaf7b9f-9d9a-484b-a89c-182615143476","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4631","original_object":"UniProtKB:P43004"}
{"id":"897bce38-a731-4c2f-a2bb-1743ff17d697","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10361101","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:9e4202ce-a226-47b7-9def-e33a8e41c003","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8194","original_object":"UniProtKB:P36897"}
{"id":"4e4fc61e-a011-4a62-8d43-1c302cbbce5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123984","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:0d6185ae-635a-476e-b8f0-1167206e513c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2359","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"b28c13ac-8283-4458-853b-483bf61fb0d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6076","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:d651f66e-e1d6-4baf-9d63-c88581747b52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6076","original_object":"UniProtKB:O43603"}
{"id":"5949ec88-1fd8-4a7c-b74e-94f317e28a74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CXA4I8AH6A","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:3a3015e9-bdbe-4f25-b8a8-17697f674257","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11304","original_object":"UniProtKB:P52333"}
{"id":"dab7ac14-1a86-49f7-8751-881f0a1ce369","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:fd363bb2-deaf-4f24-bea7-13b96328b712","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:Q9EQ31"}
{"id":"a7a37a07-f67c-49dc-b174-97fff75dd386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9244","predicate":"biolink:affects","object":"NCBIGene:3604","sources":[{"id":"urn:uuid:8870241c-6110-4fd6-a8d2-6dab032b374e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"antibody_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9244","original_object":"UniProtKB:Q07011"}
{"id":"119c37e9-f302-40ba-8690-b0cc8c178e50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71526553","predicate":"biolink:affects","object":"NCBIGene:1071","sources":[{"id":"urn:uuid:f184869b-ca1c-4440-9350-7eb6e3e64034","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11729","original_object":"UniProtKB:P11597"}
{"id":"74d42cb9-e535-4ae4-9926-1df79b3541ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:e9dbc338-35c9-4dac-8e55-83c00e5c8c32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P50406"}
{"id":"800d39ca-d93a-48b4-af2c-167f321c2059","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3361255","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:1264426b-d6c0-4c2e-b06e-c32ae640dd9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8083","original_object":"UniProtKB:Q9NWZ3"}
{"id":"6602d8c2-6876-48d1-9102-43bcf7cacf10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:193034","sources":[{"id":"urn:uuid:ee21b346-e294-4455-b47a-606a32b4fc80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q704Y3"}
{"id":"d432d2fd-d389-4718-982b-c75f9828a958","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76204","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:65355f0c-5201-4496-af6f-f6dac9e7f7d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11973","original_object":"UniProtKB:P35354"}
{"id":"17800119-57eb-43bd-9965-3d424be239ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O4BT6C02M2","predicate":"biolink:affects","object":"NCBIGene:5696","sources":[{"id":"urn:uuid:b07c8aa2-45bd-4643-ae28-3edf6eb12daf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10409","original_object":"UniProtKB:P28062"}
{"id":"9ff5916b-cc9b-49ec-87b2-9528c82e6b90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139533572","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:c3d80316-e985-464f-a7c0-a5b1c4d2c435","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12249","original_object":"UniProtKB:P30530"}
{"id":"3853f2df-5be3-40f1-b8bf-acf09532b35a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15365","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:fc6530d0-1e71-4f4b-9997-e3e77885368d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4139","original_object":"UniProtKB:P35354"}
{"id":"a0eebbe5-4825-48e1-a956-aa914241a046","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:b70e80c4-2895-4a26-adca-b1d5bf7d8d02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:O00329"}
{"id":"463c66de-5639-4b2f-80e2-e2b8c987bbd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1043","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:fbb4c89f-38e6-48de-b6c5-67e6602a863e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1043","original_object":"UniProtKB:P25090"}
{"id":"4edbb14f-a63b-4ff1-ba46-860b7c5b2d53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91366","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:29e57ddf-ccd4-49f8-a53f-bb9803012a91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5696","original_object":"UniProtKB:O14965"}
{"id":"b32ef5f3-0c37-4d2d-bd0d-6fd5e319a441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138000","predicate":"biolink:affects","object":"NCBIGene:25590","sources":[{"id":"urn:uuid:92c83bb0-6651-458f-89fd-9ad490168586","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3978","original_object":"UniProtKB:P09483"}
{"id":"da441aa7-343b-45ec-ab69-5001d8276341","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122130461","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:d7d7688f-8f05-4a49-81b6-b6f52d45773f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:139","original_object":"UniProtKB:P30966"}
{"id":"c7eff674-9ab3-4d72-a863-cb3bca24bda9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91452","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:a9d585aa-03ce-4a59-9b83-b70e9e65b9bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9382","original_object":"UniProtKB:P08069"}
{"id":"6fc78183-2e90-421d-8122-aebe2e0381ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:c87e40ba-54c2-4afc-ab21-a847bda725c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P48169"}
{"id":"7e0675e3-47a9-4178-8254-6095a948edb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:bbceddf6-a4ce-4d36-b64e-9d1e8d99f089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:P49146"}
{"id":"13f76e08-ce32-41c3-aa42-d9e8b6d7e084","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:a0c8049c-5175-4295-8b5a-75732121500c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P32305"}
{"id":"9f048cc6-27d6-40cd-b7b0-6b7ee426afbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:USO2D5J77R","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:c5044d39-1ec0-4e33-83bf-527d0fc12401","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12649","original_object":"UniProtKB:Q9H2S1"}
{"id":"2d3db0b3-6984-4d9c-bad2-6ed0a0cc471f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R9X77R42FN","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:f3c0b4b3-88ac-4dfb-b95b-032ba08c5bff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:301","original_object":"UniProtKB:P08912"}
{"id":"a4cde215-9b4e-4129-8ab3-f5514bfe8b49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118522534","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:b3ad0373-2374-4784-89ce-b8dfc1a8d4fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12318","original_object":"UniProtKB:P23458"}
{"id":"59b8c947-9efd-4121-80ec-d782af328411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44143209","predicate":"biolink:affects","object":"NCBIGene:390245","sources":[{"id":"urn:uuid:6fe736cc-23b5-4fcf-919c-d9060d789c41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9584","original_object":"UniProtKB:B2RXH2"}
{"id":"99d611ee-1b66-4845-9863-b73284b0dd4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125619","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:fa9e1da5-f049-444a-9c91-185cbf832754","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:80","original_object":"UniProtKB:P21917"}
{"id":"8c4d11fc-89be-4afa-9767-315dd44556e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:c203d6b9-fe92-4d78-9368-8383e33144c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q62053"}
{"id":"bfb15fc4-e68f-43fb-9f71-102d3e7955db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6339","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:13d206ba-9899-4d19-ab94-9be3bf068063","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2896","original_object":"UniProtKB:P35354"}
{"id":"aef4ddf4-9374-43e9-884b-d12368a7b9bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:45WZM2FLYQ","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:cb8ed95d-43ef-4b49-b2b7-bcdd00ce4a30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4023","original_object":"UniProtKB:Q9Y5N1"}
{"id":"7ca5427d-4558-44d5-b858-2b71fa488854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67SX9H68W2","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:81660ea2-84b2-492c-9033-184dd276ee36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10456","original_object":"UniProtKB:P00533"}
{"id":"8ed061dd-90fb-4d78-aff0-395e618c5606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:fc3312b7-a578-4b7c-a449-ec490753d7ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P32305"}
{"id":"52275ff6-09e0-4797-b1d4-c5526a7da825","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:14739","sources":[{"id":"urn:uuid:5c0c5eec-45b0-45d9-8b63-497a24c7943d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:P52592"}
{"id":"a254e248-fd04-483a-bbc7-6c616b330bcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92988","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:318d71ff-00a4-4d98-909b-f2897e2dde0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:813","original_object":"UniProtKB:P51685"}
{"id":"0e3217f6-c743-457e-ab62-c0853e3c7777","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:69fcf8be-3874-4b70-95aa-b6b597875cef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2291","original_object":"UniProtKB:P59540"}
{"id":"b8e08d1f-dc38-47a3-b18f-96c54bd152e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231599","predicate":"biolink:affects","object":"NCBIGene:57097","sources":[{"id":"urn:uuid:fdcc2448-c4fb-4ae3-8d22-8946efb59c15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13123","original_object":"UniProtKB:Q9NR21"}
{"id":"0f3d6b4c-faac-44dd-bb49-7652040779e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118639856","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:bcc7ada8-e5e2-4efb-885a-a2d71cb3b5d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11877","original_object":"UniProtKB:Q9UM73"}
{"id":"71b87833-3d39-427e-966e-7aad7f57d3ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16893","predicate":"biolink:affects","object":"NCBIGene:81491","sources":[{"id":"urn:uuid:a1c09f57-70b0-4fb2-8151-c0d30b599482","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2921","original_object":"UniProtKB:Q9BZJ6"}
{"id":"5fd2043a-ac74-4730-b813-6cf7f54a75c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1381152","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:ab1051a1-770a-47ce-aac5-aefe4cdef47e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8726","original_object":"UniProtKB:P49798"}
{"id":"5fe271dc-8046-441e-bffc-44f31e1fb4ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91933875","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:1168c211-e438-42ea-9ff2-d027941f6179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9452","original_object":"UniProtKB:Q04759"}
{"id":"09f00ea6-7f1e-4fca-8ea2-01a054711a82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46945265","predicate":"biolink:affects","object":"NCBIGene:1593","sources":[{"id":"urn:uuid:d2ed54e6-8335-4f96-aeb7-3b5ecc9ad617","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8852","original_object":"UniProtKB:Q02318"}
{"id":"0aebcfd0-4974-47bc-8a07-764630daa8b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N3Z657H81X","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:2c660a66-cc98-4702-a70f-636991040031","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1547","original_object":"UniProtKB:Q9ERC0"}
{"id":"f6cd227f-686e-4222-9361-2637ab9a7c14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:ac0046cc-307f-44e8-86e2-bd341d2ce84f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:P21817"}
{"id":"8676baee-eacd-413a-bd47-0aeba041a10e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73442760","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:7b149edc-2c93-4f87-997a-14b62dd6350d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9366","original_object":"UniProtKB:P36888"}
{"id":"159cf24c-a4a7-4692-8660-42a2fb0c45ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2383","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:6ffad7a6-4fbe-4923-885e-e227b91bdf79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2383","original_object":"UniProtKB:P35560"}
{"id":"e8950397-8736-4ffb-9ce0-052e47d22543","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:12Z0SU967A","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:df863606-02ba-4348-ae1c-cce28262a3fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1935","original_object":"UniProtKB:P35408"}
{"id":"d85be59a-2aa0-42c8-abe4-2dd4a2d8fc1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232985","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:52e3b645-d516-4472-bdff-10f1c59bd894","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2318","original_object":"UniProtKB:Q9UGI6"}
{"id":"bccdd4c8-4b05-4a52-90aa-161817012337","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47499","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:535fa976-1e0a-4e17-999c-69136dc4596b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:357","original_object":"UniProtKB:P31645"}
{"id":"d95b8d01-932c-4573-857d-e8343edf0f37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611890","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:22753088-81b0-4a49-8cbe-02a7b26dd4fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9980","original_object":"UniProtKB:Q9NY46"}
{"id":"36841749-6f93-4e79-b2d8-36f0020efcc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352782","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:5c29e8aa-2808-4341-8b2b-b71200293564","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3083","original_object":"UniProtKB:Q02769"}
{"id":"0283d07d-8312-483a-8764-9a94ebed2b06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699451","predicate":"biolink:affects","object":"NCBIGene:54302","sources":[{"id":"urn:uuid:2e9dd06b-4dc7-4560-a4cc-9ddd12bf8bae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11156","original_object":"UniProtKB:Q62668"}
{"id":"53accc46-ca0c-4ce3-83f8-436563651db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:dca92fdd-c8ce-40f6-867b-a1be31fd651b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P61169"}
{"id":"553d5fe8-4c6a-458e-9453-855e1b14560d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6702","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:339fb8c2-3fbd-459a-91cc-4859d095abd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4797","original_object":"UniProtKB:Q01959"}
{"id":"de732ecb-b39b-4cd3-8740-eb36838ad1c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136416849","predicate":"biolink:affects","object":"NCBIGene:154968","sources":[{"id":"urn:uuid:e85a7cef-9e41-42a6-97a8-57ac5bffef38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10508","original_object":"UniProtKB:Q8VIJ5"}
{"id":"dcf160e6-009e-4c09-a97e-9bce0a588c35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321937","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:e4162ec6-3f42-41a8-940e-5e8abcbf0731","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3979","original_object":"UniProtKB:P32297"}
{"id":"cfc341ea-e629-4c39-91ad-15e8163844b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44285652","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:da6da657-034c-44be-b0aa-69bf947f11fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7993","original_object":"UniProtKB:P04035"}
{"id":"0ed2b5e3-609a-4aed-906b-259525878753","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70773","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:57dfe24c-6970-465d-ad40-36539935193b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2461","original_object":"UniProtKB:Q8R4D5"}
{"id":"76a0df4a-a1d3-461a-bc8f-f20f806ce67a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91083","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:db89fa0b-6d46-4e14-96a6-1aeec495fc9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5056","original_object":"UniProtKB:P35968"}
{"id":"f4e3f7b1-924f-4043-8703-d9c06fe51a11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:bfe8a541-f082-4e5f-b852-2ac9cc6c6ac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P16234"}
{"id":"ddf0c059-67cd-406b-bf03-41624a5c0b0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:3e332bd7-4fd0-48ae-a44c-f9b4405ceb4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P28221"}
{"id":"dc3bc18a-da90-49c1-89c1-08c9fc36faea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:515950","predicate":"biolink:affects","object":"NCBIGene:837","sources":[{"id":"urn:uuid:feac9a5b-0999-452a-aa04-f23c4b305cb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8635","original_object":"UniProtKB:P49662"}
{"id":"68aa2e7a-cb60-4cf2-96c1-8702b0d9cf6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132316","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:ab7f9383-dcb5-4a2c-b1ce-6a125f2c7d30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1643","original_object":"UniProtKB:P33535"}
{"id":"a64b0f57-71ce-4488-be4b-a5a138583a8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118597685","predicate":"biolink:affects","object":"NCBIGene:23081","sources":[{"id":"urn:uuid:e293ec2a-e624-42cc-a2a3-d335b680d89b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12807","original_object":"UniProtKB:Q9H3R0"}
{"id":"f0de87e1-efd1-426a-a970-08906cba406f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:309713XSKW","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:52a401bc-a970-46bc-a767-8ce63536998b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1244","original_object":"UniProtKB:Q9QYN8"}
{"id":"9d55aeb6-1974-42ae-96f0-9f5590424bb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91495","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:a32a372c-5cec-46b6-a066-919854265340","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:325","original_object":"UniProtKB:P08173"}
{"id":"9fe2fcff-8819-4702-818e-4740d9fab348","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S173RED00L","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:01a9fc73-b5fe-4a66-9a5e-5b263a7df15e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10732","original_object":"UniProtKB:P00742"}
{"id":"8e86ae8e-7317-49ba-bee9-825828600093","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13328","predicate":"biolink:affects","object":"NCBIGene:5970","sources":[{"id":"urn:uuid:1522635f-b520-4738-ac5c-d37956f828c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13328","original_object":"UniProtKB:Q04206"}
{"id":"8bbdbd09-9019-4c23-a9e7-d63014091f36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8334","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:51d08c34-8363-458f-9478-1d5d87f75aa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8334","original_object":"UniProtKB:Q8TDU9"}
{"id":"96308b48-5001-44d3-a78e-a33999dd66e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94490","predicate":"biolink:affects","object":"NCBIGene:9748","sources":[{"id":"urn:uuid:ce89407b-f8ec-4948-9e3f-2a1e2c3edcdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7937","original_object":"UniProtKB:Q9H2G2"}
{"id":"8868a9e7-10f5-4a18-b1d5-81c273ba574b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3207","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:6b7b34a3-0efc-4317-abad-5016725ad418","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7434","original_object":"UniProtKB:P04150"}
{"id":"b1eb7c57-9185-4a35-8384-29852bb6ebbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58561243","predicate":"biolink:affects","object":"NCBIGene:4836","sources":[{"id":"urn:uuid:fa8b8c30-d75b-4f86-98d6-8673adfd6877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13851","original_object":"UniProtKB:P30419"}
{"id":"49890f93-976d-40a3-97fc-917aa49007ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25220500","predicate":"biolink:affects","object":"NCBIGene:4929","sources":[{"id":"urn:uuid:d2c49feb-a0b7-453e-a02d-4af70d0538ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12998","original_object":"UniProtKB:P43354"}
{"id":"8273c6a0-237b-48eb-886f-64284f77799d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21202952","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:b945eda3-918f-469e-84ce-74b01d6a3d06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4208","original_object":"UniProtKB:Q14957"}
{"id":"afb3e1dd-5c38-4126-a5e0-98e1e0073f38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15811","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:bb20cf98-70a1-463e-b9b6-d30938182e0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1411","original_object":"UniProtKB:P31423"}
{"id":"6c84d589-3dbb-4c18-b961-16554e3dc1e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13365","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:63bd920a-3aeb-43b0-9a14-7810b66a68de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13365","original_object":"UniProtKB:P07711"}
{"id":"d707eb13-1e47-4eaf-8765-eae512cebc68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:921","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:8bf34749-1b75-4281-b9a7-af7a4951e6b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:921","original_object":"UniProtKB:Q13324"}
{"id":"3a7f1e43-a5c6-4caa-9719-d25dd46933bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5707","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:a7f8e41c-220a-4916-902b-8274b4bc2f44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:323","original_object":"UniProtKB:P20309"}
{"id":"76eacc8e-71a3-4ae2-8cbe-7a7d378ce979","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:b85388c5-7ac6-41f2-9a25-86ef92d7c880","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2476","original_object":"UniProtKB:O95180"}
{"id":"2c946e7e-1a1f-4af9-9326-4c2bbc2b899b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153520922","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:39226c8d-d380-49bc-9aec-082fea456a15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12304","original_object":"UniProtKB:P11229"}
{"id":"ea1f3a18-53f1-4806-8300-1a5040895047","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13876","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:859dc1cc-8fe2-4b36-a0b1-65a5e8c9c835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13876","original_object":"UniProtKB:P55899"}
{"id":"19d0415c-d9a5-471f-b73a-0f810951bfb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85572","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:3e2527b5-0ecb-4980-af57-90c68fcab63f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9360","original_object":"UniProtKB:P42345"}
{"id":"5524c881-9798-4c1c-a16b-73372bde160e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9271","predicate":"biolink:affects","object":"NCBIGene:50832","sources":[{"id":"urn:uuid:dbbf197c-34ec-4571-b0bd-9c78818621f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12423","original_object":"UniProtKB:Q9NYW5"}
{"id":"4f032edd-9744-4ae2-9dff-6c982af7d1a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11624321","predicate":"biolink:affects","object":"NCBIGene:3162","sources":[{"id":"urn:uuid:e4bf60f0-87c9-403f-9aa0-ddc3dced7d0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8873","original_object":"UniProtKB:P09601"}
{"id":"83789184-3db4-4b78-84e7-46ea50d97247","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:573663","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:5dc53979-4465-4afc-b608-cf395339d2c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13881","original_object":"UniProtKB:P56817"}
{"id":"c8089ff0-d59f-4081-abce-bc3d01f60e0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6095","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:c1acef90-1bf2-4d10-97ed-3dd3e8b38dda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6095","original_object":"UniProtKB:O08726"}
{"id":"74b5c251-b4a4-4eee-b71d-9ff3f51810b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91747","predicate":"biolink:affects","object":"NCBIGene:108","sources":[{"id":"urn:uuid:cd963211-edf7-4e6f-a752-abf5fdec387c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:944","original_object":"UniProtKB:Q08462"}
{"id":"2afbadf5-9ab3-4e84-a4bf-7d16b8af2be7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135736","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:8fd01b12-fb77-47dc-9375-afbb5532b581","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3950","original_object":"UniProtKB:P25101"}
{"id":"fca34dd1-5c7d-4864-bc17-c8d02aecf27a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311494","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:9b17ef78-b231-493e-9b4a-ab3e06639315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1735","original_object":"UniProtKB:P41231"}
{"id":"ae57c48f-f56a-45f4-a653-6054812c8784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9139","predicate":"biolink:affects","object":"NCBIGene:5146","sources":[{"id":"urn:uuid:f62a7b77-d40e-4859-a9af-3b625185c2f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4743","original_object":"UniProtKB:P51160"}
{"id":"a5ffacd6-97fd-4ce9-acf8-4682a6399778","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168284044","predicate":"biolink:affects","object":"NCBIGene:165631","sources":[{"id":"urn:uuid:b7448815-260a-4f14-aa7d-5236bc536e71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13122","original_object":"UniProtKB:Q460N3"}
{"id":"ea32ce65-dca6-4bee-a0d9-918316e8acb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:89b2dc59-d7a0-49b6-a491-c3abc3de7d5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:P41594"}
{"id":"5f63e473-16f5-4606-8b8a-b82bdb0665d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:8cb484ee-88c7-4ae6-9683-d9f1a5da6766","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P14416"}
{"id":"f72e703b-848e-44bc-8786-e9c926bd605e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93458","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:32aad6ce-944a-47f7-acdc-70de55ebe4a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:779","original_object":"UniProtKB:P41597"}
{"id":"a09fa794-4066-4842-84f7-348bf50f861f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:992293","predicate":"biolink:affects","object":"NCBIGene:9194","sources":[{"id":"urn:uuid:9b623e77-2a88-4041-9905-2a0131c4869e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10405","original_object":"UniProtKB:O60669"}
{"id":"8894746d-4576-467c-8254-5d1ecd99282f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135939","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:b31c7162-cbd8-4b74-af63-900a67fef263","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7472","original_object":"UniProtKB:Q15858"}
{"id":"2ced6870-0364-41a4-85a0-b5a0ad4b49da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V5SE449P9L","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:2e6a46cb-786b-43c7-97a1-7d36180b92f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11406","original_object":"UniProtKB:O14684"}
{"id":"d8eacef3-5225-4909-93ad-38c82233f5a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155269708","predicate":"biolink:affects","object":"NCBIGene:8408","sources":[{"id":"urn:uuid:1fda6594-3b93-4646-a80a-760f1cc8b45f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13209","original_object":"UniProtKB:O75385"}
{"id":"e85c0eb3-2e0c-4eef-992a-ef2ae5898978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5FI5376A0X","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:8c83bc02-2cc0-4483-8ece-0467757f73fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6926","original_object":"UniProtKB:P36544"}
{"id":"e28901fd-21c5-47d4-a455-4a71eb656454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46836562","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:1d3bf63c-7e41-4de9-85e7-1abb14115222","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6231","original_object":"UniProtKB:Q14833"}
{"id":"12d4c9a2-9462-4257-b80f-64a3d921e434","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699459","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:8161f58b-84c9-4662-812b-cb0f38d90bc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11198","original_object":"UniProtKB:Q16288"}
{"id":"95597f12-cf30-493c-9b52-abf65bc6f227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9NB8N7LZ92","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:7190f954-8d88-482e-8e97-94dd03e06bcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12444","original_object":"UniProtKB:Q9NYV8"}
{"id":"2925c11f-c5eb-493b-bfef-b6ddf84ada6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230905","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:32b8cb2e-89ad-4c61-855a-feb720728e72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7383","original_object":"UniProtKB:P11802"}
{"id":"c123be8f-90a6-4a39-a5dc-50b08839f97d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71508234","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:c29096ac-ed92-48f7-a8dc-2838b1110f18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7924","original_object":"UniProtKB:P49286"}
{"id":"1dd73642-9c13-4985-8e6e-9bffd23a3a0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:15a0930c-41ee-4880-8f77-80a8ebd7a2c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:P30543"}
{"id":"ea915488-f5d7-42e4-bc62-f914d7ba3bb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10591006","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:1890aad7-de05-4871-afa8-49b9a466dd1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3115","original_object":"UniProtKB:Q02769"}
{"id":"fbce397c-d609-43dc-b224-cedad3227c00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8206","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:5a16895b-723b-4fc8-b790-c7b5cf47adce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2291","original_object":"UniProtKB:P23416"}
{"id":"eadaf094-bd59-402e-8a6b-ba43af0b105d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92714","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:6debde7d-4515-42c0-bc43-d017473cc6ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3288","original_object":"UniProtKB:P29274"}
{"id":"a25480de-a75f-49a5-8d8a-758b262e2b7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5193007","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:6a1d5784-b904-43d5-bfa5-90ffdf84f574","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5943","original_object":"UniProtKB:Q00534"}
{"id":"e1aaed34-b760-4201-a26b-8ccb3ee2fe11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232354","predicate":"biolink:affects","object":"NCBIGene:347411","sources":[{"id":"urn:uuid:48cded98-8111-41b8-920e-04527413f156","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11302","original_object":"UniProtKB:P0DKB6"}
{"id":"b7f15e1e-9e8e-47f6-9f5e-7c531fd216c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63115","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:cd179c80-b78c-411b-9c46-cb3400b65f18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2407","original_object":"UniProtKB:Q9H228"}
{"id":"4dfbb193-e940-4656-b9c4-820eb824738c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9592","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:85cba33a-7ac1-451b-a05b-fa2a88357c16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6499","original_object":"UniProtKB:O15552"}
{"id":"d86a54c4-e33f-455b-8a3c-6f06cb11ef2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11259583","predicate":"biolink:affects","object":"NCBIGene:13610","sources":[{"id":"urn:uuid:cda50da5-0b27-4549-966c-81113a755aeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2925","original_object":"UniProtKB:Q9Z0U9"}
{"id":"1812f984-7fde-4de6-ae1d-b5118cdad5da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49872868","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:84b398f9-14d9-4f73-ac75-ed85c052ba38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8777","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"662c83f7-fe38-4b5d-a90b-3cd1d55c0413","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53316381","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:81ead529-5c05-4a9c-808a-458de1a931e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4778","original_object":"UniProtKB:P48067"}
{"id":"18e83dda-ed9e-4fd4-82a5-7de4741729b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34946","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:530f2172-bcf2-4157-919f-0d9d7043a026","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1739","original_object":"UniProtKB:P41231"}
{"id":"b866d9c7-2b39-4a1d-b90c-f6cb97fc65d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73295","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:ad83679f-2b28-4c9e-9867-b50748a82b1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:733","original_object":"UniProtKB:P23416"}
{"id":"380cadc0-32b4-4a71-9707-b08f1e6c9edc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10148412","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:6c3000a4-f872-412b-8746-53fef372852a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1473","original_object":"UniProtKB:Q9GZQ4"}
{"id":"b091ffd4-71e3-4d30-8ef6-0be852ec6f43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11641563","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:27c9d1a4-121a-43cb-851f-6a3552c5dafc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7823","original_object":"UniProtKB:P14780"}
{"id":"7add3070-3614-42ef-8d6a-9e92f0524859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2622","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:8c1d51c5-2e0a-4cbc-8ddf-27de577018bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12459","original_object":"UniProtKB:P59537"}
{"id":"b5227766-1b5c-4d8c-8e70-51eb1887147f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135351","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:dd153707-7cee-48b6-888c-23dab1c579fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:941","original_object":"UniProtKB:P21728"}
{"id":"069be0b3-3eb5-4493-a93b-e06d473a8fd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O4BT6C02M2","predicate":"biolink:affects","object":"NCBIGene:16913","sources":[{"id":"urn:uuid:ef3355fb-031a-40f9-938f-334524b4cbc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10409","original_object":"UniProtKB:P28063"}
{"id":"30231a0b-f93c-41af-ba8b-31d9a726a9cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173971","predicate":"biolink:affects","object":"NCBIGene:83756","sources":[{"id":"urn:uuid:665606d6-8dde-4af6-b411-822e74a8dbbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13900","original_object":"UniProtKB:Q7RTX0"}
{"id":"99d14f50-8dcb-44f9-af9e-327edb44493f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5720","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:160f2df2-254e-472f-b318-0371db0af8de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:324","original_object":"UniProtKB:P10980"}
{"id":"825d4e9e-c33a-4e69-bae2-1e4b3de52258","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JAC34RRR7S","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:9f4aec85-c694-431b-b233-4da021e11ec0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11716","original_object":"UniProtKB:P23458"}
{"id":"cfed8f4b-695c-4556-b6e3-e2810f040013","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4160","predicate":"biolink:affects","object":"NCBIGene:259232","sources":[{"id":"urn:uuid:8cc7f918-6c5d-4d68-8da0-c4c5bc4a2115","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4160","original_object":"UniProtKB:Q8IZF0"}
{"id":"04144d0f-f0ab-4e51-ac4f-45ea77fdc74e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13134","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:9f38b6d9-014d-4c81-b0a7-9732ad1ee3e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13134","original_object":"UniProtKB:P35348"}
{"id":"31b4c889-4900-4b2b-9c12-d818f290086e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117902000","predicate":"biolink:affects","object":"NCBIGene:9020","sources":[{"id":"urn:uuid:ce7d676e-a240-440e-ba87-a68db5c25834","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9964","original_object":"UniProtKB:Q99558"}
{"id":"713b8323-2a04-4b8a-a835-17959a62068f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1545","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:17c3e989-34f8-4c8b-b036-7ca4ecdfeaa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1545","original_object":"UniProtKB:Q61041"}
{"id":"d90e4a86-2419-4206-a5c9-b60b5b101cb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177746","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:e9a365f8-5f63-4fcb-bbc0-332780ec3df3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7956","original_object":"UniProtKB:P35968"}
{"id":"bc467bdb-21cb-40ea-8fe1-149748e077d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:64600","sources":[{"id":"urn:uuid:7405fa34-7542-41ea-a3b8-644122542c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:Q9BZM2"}
{"id":"8b990cc1-4bbd-4ccf-800b-db7820909249","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:2ff3a015-e0dd-47b8-8556-39fe427ada5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:O96017"}
{"id":"74c0215c-bd3f-48cc-a4c7-b9b879fa288b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93782","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:0ddf19c3-f5b4-4b5f-bf50-bf13d7136add","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9509","original_object":"UniProtKB:P14780"}
{"id":"9a2eb2fe-9e34-473e-a7f9-89c07e8bba65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15713","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:d7e4802c-aa96-4eeb-949e-2f4bbf4b8179","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1734","original_object":"UniProtKB:Q15077"}
{"id":"8f65cf2a-1783-4745-8873-048747c53671","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13836","sources":[{"id":"urn:uuid:d7a2a2a4-0225-47a6-8127-3ae151bde777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:Q03145"}
{"id":"20dfff3e-2a08-441c-bfec-efba7f4d7f41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1992","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:5ef72d14-0b6b-4698-a1c7-593080f4cd43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1992","original_object":"UniProtKB:Q8WXD0"}
{"id":"bbcb188e-f1e7-4485-b160-54eacf99ffbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:66b26952-1cd2-40bf-afaa-40cb25b4e04c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P41595"}
{"id":"3e76fb3a-d5cd-41f1-bbac-5e9e6f0c06b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:fe2c000f-6a66-46d0-a1fe-9d8d10c5a328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P28566"}
{"id":"aa2e5e3b-5834-4997-9308-cad6472cffbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311503","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:2c569d9e-f4f1-4bcb-8284-3c83ced01448","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1889","original_object":"UniProtKB:P34995"}
{"id":"993cdd34-b2f0-48c3-9e59-28691a43d824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65349","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:c8909440-1bf0-476b-871c-3465cc511e7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7445","original_object":"UniProtKB:P26255"}
{"id":"3889882f-f0a7-44d4-be21-90b55ed1d214","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XG52JC545T","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:dac16c58-81aa-43c1-b5f8-a59444c78e81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3415","original_object":"UniProtKB:Q15722"}
{"id":"bbcf0d53-02a5-48c6-bdf5-48064ecb9242","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:50839","sources":[{"id":"urn:uuid:e6ff5a0a-6c3a-4ce5-a5a8-7da6f8a7e57a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:Q9NYW0"}
{"id":"be17b640-0066-4c1b-9c47-af2fb34c3b5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688563","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:8e5f49b0-f7e3-4c29-befe-544507b55959","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8119","original_object":"UniProtKB:P53671"}
{"id":"dab96de2-cecd-4d4f-9153-8111af55068e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5353593","predicate":"biolink:affects","object":"NCBIGene:16542","sources":[{"id":"urn:uuid:8c444445-222c-4e49-9c55-406e11d475f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5958","original_object":"UniProtKB:P35918"}
{"id":"81106029-edc6-4f8c-be9c-98e6f6465c9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:4c39b047-c290-411e-a410-08295b6bc619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P30680"}
{"id":"6f13b3fd-8573-4376-b88b-95854685e57f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124917","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:22046604-9119-405c-9af0-2fd9ae1e50db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7960","original_object":"UniProtKB:O14757"}
{"id":"e6705256-06e3-43a9-b11f-2fb62359ec21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67991","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:7e8d78f7-3e81-4a51-a719-a6c9161c25c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7658","original_object":"UniProtKB:Q12809"}
{"id":"03ab1cba-74c4-478e-be77-141f565a46d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310983","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:33847150-b661-4f31-b1cb-c21dfafb27f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1711","original_object":"UniProtKB:P47900"}
{"id":"a82b5512-52ec-4fea-98a9-e5d2344f80fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92436","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:454b03db-8794-4b04-a50b-fb8f0066ca95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3509","original_object":"UniProtKB:P30553"}
{"id":"61b8328b-865a-4c74-94f7-6705788b9968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92732","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:f51268a8-17e5-4868-a336-5fc0a032d6d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8245","original_object":"UniProtKB:P00533"}
{"id":"860f286b-4c21-41a9-b9bd-6695f27d2454","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679537","predicate":"biolink:affects","object":"NCBIGene:171166","sources":[{"id":"urn:uuid:ec926ed7-4722-4ec8-8dc6-5a4610c47fc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11847","original_object":"UniProtKB:Q8R4F0"}
{"id":"35044fa9-3b8c-4210-a670-4caef5562ccf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90705","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:4a8f9b27-d62a-4f4c-8d81-0b893d66f8a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5269","original_object":"UniProtKB:Q15759"}
{"id":"bf003c5c-08b7-4f4b-8df2-261687095857","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16865","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:482b0a3a-2ada-4ccd-8e42-d5423a4eee5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1067","original_object":"UniProtKB:Q9Z0U4"}
{"id":"e030cdcb-dc5a-431a-bfbf-5d512bf848d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11912","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:c353178f-c83d-414b-ba6e-2a7915450040","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11912","original_object":"UniProtKB:Q9NSD7"}
{"id":"6b402999-3814-4f3d-939a-d454f8b9356a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9757","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:0746b727-3626-48ae-b4e4-f21c2748a2a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7319","original_object":"UniProtKB:P08912"}
{"id":"61db98fb-0c50-4ecf-97ed-095bb49653e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:97214c8c-1a25-43f7-929d-5575588b72d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:P50750"}
{"id":"9c099df3-4d39-4690-a66f-5f0a190945a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16469","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:723b64d5-45df-445f-8de8-11ce0928dd9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1013","original_object":"UniProtKB:O75469"}
{"id":"3a1bf73a-e7cf-4d13-bd8a-728082d141ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136059718","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:d0143885-9ec1-434a-8c85-9bc797d26f4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4588","original_object":"UniProtKB:P13866"}
{"id":"3c86319f-fef7-4245-b93e-8f6b426a99fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90620","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:6c31bf1d-7b94-433e-b7b4-f5720dd831af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5705","original_object":"UniProtKB:P09619"}
{"id":"93b1bd0b-270b-4d6b-8625-4b8ee768d037","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66524380","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:53565f1d-a420-4353-9860-4578d7fe4a75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5695","original_object":"UniProtKB:P36888"}
{"id":"29f4acee-ad85-4248-ac2c-0247ea5bb63d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:915cd2fd-3aa3-44e0-8b02-6f2eec1025de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:O15379"}
{"id":"cfbde9de-0d36-4dd2-ad8d-2e2c0f57f9bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71663862","predicate":"biolink:affects","object":"NCBIGene:23173","sources":[{"id":"urn:uuid:8895e516-8a69-4bfc-bfd5-9b7d2648f089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8557","original_object":"UniProtKB:P53582"}
{"id":"426e3b6d-59f5-40d9-afd2-740efc6d620b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82813","predicate":"biolink:affects","object":"NCBIGene:30952","sources":[{"id":"urn:uuid:f9960c4a-1e69-47b4-9d34-3ac20797168a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2349","original_object":"UniProtKB:Q9JJZ9"}
{"id":"04981518-3e28-4a4e-b29f-e8a70017065e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93201","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:0c3a154d-06af-48a1-ad0c-ffa8105e8240","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4347","original_object":"UniProtKB:P31644"}
{"id":"1ced5bbd-e3ea-4c1f-a588-5709ba514946","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4712","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:084855da-3dbc-4f63-bef3-80913683724c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2790","original_object":"UniProtKB:P11473"}
{"id":"a1e6b4c9-75a3-4b96-95fe-2376218ed1ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101381","predicate":"biolink:affects","object":"NCBIGene:1511","sources":[{"id":"urn:uuid:9fec138c-3edc-4201-99ef-5481c533726d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10714","original_object":"UniProtKB:P08311"}
{"id":"f8d962b4-f510-4cc3-9539-ecf7768ebaed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8925","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:2492980a-ae94-4dbf-bb06-d82bc115b2ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4303","original_object":"UniProtKB:Q15413"}
{"id":"52f85e00-f87a-43b2-bb0e-b7c6be7e7d05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64139","predicate":"biolink:affects","object":"NCBIGene:100","sources":[{"id":"urn:uuid:2169b0a1-1daf-415a-ac43-57cdb2abd2e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5179","original_object":"UniProtKB:P00813"}
{"id":"14c86e32-d08f-4328-977b-ab8d06fa581a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164628824","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:45d48fad-d41f-48bd-b164-6cb8a9baaa25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13634","original_object":"UniProtKB:P0DTD8"}
{"id":"c6352cad-1165-4234-97f5-335339c2c466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10086833","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:56250d31-1392-49a5-8780-90763067f3d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3175","original_object":"UniProtKB:P14324"}
{"id":"32eb3c09-0d28-4700-92cc-e0b620fe6d37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277842","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:8185d5c8-16d3-4bf3-83f9-e7afa1ce8d8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7807","original_object":"UniProtKB:P25440"}
{"id":"fa11ad2f-3e12-4741-9fc9-a254d2acffc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:1e8f588c-fd13-4769-b32e-b87826505495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:P08909"}
{"id":"24d17d9d-9356-47ce-a21d-4e920319df4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2615","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:7ff4495e-55e5-4df0-8a32-bb3915a02c04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2615","original_object":"UniProtKB:Q99250"}
{"id":"bb8ea1c6-4a29-42df-b5c9-527260d8a512","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10426487","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:fba59ec0-a3e3-4588-9fc5-d184815f8f56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:291","original_object":"UniProtKB:P11229"}
{"id":"08e6b759-ee16-4458-84f6-be65f176e75e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126619980","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:e84ebd40-a8af-4c23-a15b-b0ee2ce63db7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10564","original_object":"UniProtKB:P25440"}
{"id":"f1af2532-8caa-40fd-8f34-caad2d52fcb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321159","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:f610e621-db05-4fc1-a6bc-327f03027b49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10156","original_object":"UniProtKB:P52333"}
{"id":"d092227f-8e38-411c-adec-c95b0dc8b197","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64122","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:85308b3e-d867-416a-8fc2-1938c0d819cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:960","original_object":"UniProtKB:P19020"}
{"id":"28078fa9-e0f2-4039-b4eb-746031311e1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:a776e6d2-e3ed-43b6-939c-70dd3f10fa8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P35367"}
{"id":"45f72c10-f37e-49ac-9f92-fc8d06d830b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122186","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:b27c1384-de24-4943-85a0-87535be084c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13194","original_object":"UniProtKB:P07550"}
{"id":"61ae9ad0-8d83-4121-87b6-dcff784a9c08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162381323","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:b3e77097-4769-4cc3-a41f-ebaf879b117f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12874","original_object":"UniProtKB:P21802"}
{"id":"8ab778ac-4589-433b-9395-30af8e04e08c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28852","predicate":"biolink:affects","object":"NCBIGene:347732","sources":[{"id":"urn:uuid:4c292726-b48a-43d6-8591-47c13103c930","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5412","original_object":"UniProtKB:Q86XQ3"}
{"id":"eb76851c-ea37-4c49-ae1b-0fb9312149d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28209","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:325b9a4d-ab62-4a4b-af59-0788efa24bd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3390","original_object":"UniProtKB:Q8NER1"}
{"id":"16b39799-1119-42fe-a19f-f9ddfc200b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2038","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:bf2f7304-b9d6-483e-a408-6be5a84de0c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2038","original_object":"UniProtKB:P30875"}
{"id":"f94e64bb-4c2a-4ea1-a3a2-531886bbdc86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156027237","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:480c61e8-a9dd-4bbd-9641-c76df95621d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11658","original_object":"UniProtKB:P0C6U8"}
{"id":"da63ceac-115a-44cf-9911-86c44a9b4569","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RAX5D5AGV6","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:ef1a0349-d282-40d7-9979-59a8fbd0e852","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10615","original_object":"UniProtKB:P30559"}
{"id":"bafb84d7-dd53-4b95-9f52-aeb5cd6e993e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6956","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:d5054fe9-8402-4b7a-86fa-041e018db1ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13149","original_object":"UniProtKB:P42866"}
{"id":"262ec223-a648-42b7-924f-dc5a77691610","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4874768","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:c76541af-46c0-4262-a6c6-499cafd60ff2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13424","original_object":"UniProtKB:Q14330"}
{"id":"19bb7745-515f-4d26-a820-a46df6d4f2b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:92044402","predicate":"biolink:affects","object":"NCBIGene:8408","sources":[{"id":"urn:uuid:bd753a3d-d432-4f14-949d-baa95cc67825","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11339","original_object":"UniProtKB:O75385"}
{"id":"9875c6c4-9a2f-438a-baa6-36f11fc7bdae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16040067","predicate":"biolink:affects","object":"NCBIGene:27306","sources":[{"id":"urn:uuid:f51ab4be-841c-4e5f-aab0-8ff671762755","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11392","original_object":"UniProtKB:O60760"}
{"id":"bd7667a5-00ab-4ffc-ab22-c34c7095362f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92215","predicate":"biolink:affects","object":"NCBIGene:25874","sources":[{"id":"urn:uuid:61daccef-884c-4546-b1df-c7476ebc653a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2919","original_object":"UniProtKB:O95563"}
{"id":"c0f1566e-bdf5-468c-8a37-5c730af62b8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:2868","sources":[{"id":"urn:uuid:892d288e-99c7-413d-a366-827d645ecc2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P32298"}
{"id":"178ebce3-536d-4594-85f6-f8862c94cd3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10025114","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:bcb14088-bfa5-499d-9e11-396a982f8ea9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4079","original_object":"UniProtKB:O15399"}
{"id":"6d2e73ad-b838-4a58-81f3-ff88fb82ef30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:b44a029a-6971-4e8e-9237-7fda607bf316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q9BY41"}
{"id":"9cdf805c-6ed7-44d1-a02e-7d64a4268332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733034","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:bc0aa5f0-c653-4d1e-9c61-3f38b3e4582a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11313","original_object":"UniProtKB:Q9UBY5"}
{"id":"b391e369-fbf7-4fd0-916e-0c9544ef06cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9823741","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:501406de-dc54-4770-afd3-b5cce3728e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2815","original_object":"UniProtKB:P19793"}
{"id":"01a2a443-ef07-4f14-bf7c-4c7e054b6ee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129786","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:8a97d2d6-a4fd-4e6d-a5b7-91fdaea870d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3276","original_object":"UniProtKB:P08483"}
{"id":"41d22e84-fbbb-44c6-aa8b-198072e1d6ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:8a451360-4727-4a77-b53e-4f115c3cf13f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:Q05655"}
{"id":"b19aa538-674d-4283-be2e-46b679594519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N33070GI64","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:d293470e-3410-47f1-aeda-a3c58da60e19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5618","original_object":"UniProtKB:P30542"}
{"id":"b6404946-7317-431b-bb81-2e49b7ef6b7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131173","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:56ca2218-21a9-4dcc-ad67-1c47e96a49eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8069","original_object":"UniProtKB:P10721"}
{"id":"a25bce2e-f3f6-4e53-9a81-a1cd64fc220d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:810","predicate":"biolink:affects","object":"NCBIGene:51554","sources":[{"id":"urn:uuid:f721126c-ada5-4114-bfab-20c45bdf2634","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:810","original_object":"UniProtKB:Q9NPB9"}
{"id":"5039cff2-bb1a-47ae-8c3e-674e25deee25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5837","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:bd1a0a90-b15d-4f90-b560-8010d50ce6b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5837","original_object":"UniProtKB:P21462"}
{"id":"7828d613-2b26-4d89-9bc6-563620cbc6cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5298","sources":[{"id":"urn:uuid:5f018d39-6dfc-4683-a843-e2e6d365fc8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:Q9UBF8"}
{"id":"acfbeb76-8027-4170-b02e-e7fb484d333d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:12003694","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:d32492b7-3c83-466f-b938-e32177734ff6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5793","original_object":"UniProtKB:Q8TDS4"}
{"id":"72626bcf-42a0-4337-8e91-e57f98913704","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8980","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:be730fb2-6729-4f97-ac31-2036d8846cff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:194","original_object":"UniProtKB:P41595"}
{"id":"e43ff21b-ab00-4891-9a85-d1400cf2756c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:ae62e320-46ab-47bb-b8d6-7be141c90577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P08173"}
{"id":"f9e64724-9272-4a09-8c04-b78fbadf731c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34732","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:b7103877-fd86-4734-accc-e99361dcab67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2605","original_object":"UniProtKB:Q12809"}
{"id":"d62a1b5f-7e85-4684-b629-b4122585892d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4184747","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:e8618eff-639e-4fbf-bc9c-da82bdfb663a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10329","original_object":"UniProtKB:P56726"}
{"id":"f1680d2f-6ead-46d3-8abc-02d1fad10504","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:02050374-94c0-4049-8362-8ab25ae7ddfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P48542"}
{"id":"205f4fbd-a71f-4a14-885c-de0cfddbd879","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10028436","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:23b78741-ac76-47ed-b088-89770179e3bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3237","original_object":"UniProtKB:P34969"}
{"id":"59a7ab12-00ca-4d47-afe9-b5c4f4a6771b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:2ec9a5ec-0db8-404f-93c4-49844801f88b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:Q96G91"}
{"id":"eccc9b0e-400c-4013-ac69-5720c3e6df48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J8RN2W0HK","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:27b1119f-ffcb-4be0-81bc-5fff063914ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9962","original_object":"UniProtKB:P10276"}
{"id":"5e6bafbd-4c17-41f6-b4a8-31c84cedff02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70934541","predicate":"biolink:affects","object":"NCBIGene:5063","sources":[{"id":"urn:uuid:df17c800-9466-4b30-927c-dce6b3c41b1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8939","original_object":"UniProtKB:O75914"}
{"id":"d67e2f9d-ac14-4e0b-9ce2-1b41bb2fd05b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16118","predicate":"biolink:affects","object":"NCBIGene:1565","sources":[{"id":"urn:uuid:18c8a4ac-a055-464f-9af7-d838302e5a8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11353","original_object":"UniProtKB:P10635"}
{"id":"609594eb-7ae5-4f99-bc46-b7182f50119a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RAT9OHA1YH","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d859561e-1cad-4cc6-a602-5d52c177467f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3925","original_object":"UniProtKB:P08908"}
{"id":"fb11fed7-834f-49d6-afc0-8ff307f5788b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8093","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:1c39e4c6-d1ac-4ce6-8e96-eed825e6f100","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:485","original_object":"UniProtKB:P35368"}
{"id":"9623cc9b-afe2-458e-b320-60f8986cff50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:762c14f8-a258-4061-b0bc-ec5146aa5555","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q9Y2T6"}
{"id":"100d30c5-9272-43de-8bb3-ae0bc9d1437e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231425","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:5f59bc51-3a26-45d2-ada9-7ad711d03336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2226","original_object":"UniProtKB:P30518"}
{"id":"ba89215d-d88f-4f88-98d2-ec0836310727","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755209","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:612f51a4-f2c0-4efd-8e5a-78db017a0906","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6343","original_object":"UniProtKB:P23385"}
{"id":"ee9f8072-a62f-4ac2-bb19-c87207b76193","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92539","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:37a4da00-7a67-4196-bee8-93b4144c8a3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9","original_object":"UniProtKB:P35348"}
{"id":"4f55b883-5e55-4f9d-9c74-6a0edd3f0cec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:836002","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:5ceacb09-a0ad-4b4b-a0bf-09e8aab89bbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6234","original_object":"UniProtKB:P31423"}
{"id":"5ea248dc-e2d1-4b38-a810-5dcd55ba22db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28197","predicate":"biolink:affects","object":"NCBIGene:2101","sources":[{"id":"urn:uuid:c92497d6-58a0-4c35-afd4-98e24b102d9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2828","original_object":"UniProtKB:P11474"}
{"id":"98ef02fe-66cb-426a-94bb-ca3ea3506e59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6942","predicate":"biolink:affects","object":"NCBIGene:3767","sources":[{"id":"urn:uuid:615160fa-4268-4988-9b33-5629c6a2881c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4254","original_object":"UniProtKB:Q14654"}
{"id":"77c272ab-ab00-49be-b4a9-b63fbb25373b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57328392","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:f5725621-d3e9-43e4-ba17-0cc379713646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6438","original_object":"UniProtKB:P31424"}
{"id":"7d531b00-f67f-4ee7-9850-6836d4b812e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:32837c21-8b5c-4ad0-b29a-2da5d5f7c7e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P35348"}
{"id":"b6983b17-80b1-40b0-9623-a03108e22100","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94501","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:6ec7ff35-6ada-4da1-a35d-44de6bd12e53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2300","original_object":"UniProtKB:P46098"}
{"id":"13421bce-db78-4fec-bc53-089cb4cf2335","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9KX8NKV538","predicate":"biolink:affects","object":"NCBIGene:25590","sources":[{"id":"urn:uuid:8813572b-76e3-439b-976f-31df721ab703","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3989","original_object":"UniProtKB:P09483"}
{"id":"06edf5fd-99b3-4817-9378-4d8853a7d93b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1801","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:34e586a3-8bc6-43ca-9714-3e42b0689772","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1801","original_object":"UniProtKB:P49190"}
{"id":"c15a24d9-f289-47e3-b102-891a904ecdd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6278000","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:791f704f-0c6d-469d-a505-d487bd729fc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1382","original_object":"UniProtKB:Q13255"}
{"id":"0c5561fe-c023-410c-9b32-4db998deced1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8254","predicate":"biolink:affects","object":"NCBIGene:57142","sources":[{"id":"urn:uuid:fbdba9a2-971e-4906-ba2d-1f40e30c62a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8254","original_object":"UniProtKB:Q9NQC3"}
{"id":"f471c3af-64da-4ab1-9512-52c6777f1931","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63599","predicate":"biolink:affects","object":"NCBIGene:6241","sources":[{"id":"urn:uuid:8905590c-4315-48a0-9481-20ad81f53de9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4802","original_object":"UniProtKB:P31350"}
{"id":"f038b727-3bba-4765-8ca0-93d15ce36baf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71682837","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:07f0b29f-dd1d-4a98-9414-ea1e06268d1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12119","original_object":"UniProtKB:P42338"}
{"id":"5865003b-08ad-47b7-ae3b-d9198aa1ace8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:366ZW99DGL","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:9095f6e3-fd41-457a-9cb6-765aa0d3c7f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8424","original_object":"UniProtKB:P28223"}
{"id":"0029cca9-0fa7-4f23-bcf5-ecc3cda7807d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11552","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:c305faab-1921-4648-bad4-994804fc1577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11552","original_object":"UniProtKB:P55899"}
{"id":"1b01b9ec-5020-4eb2-9d74-73f287fd3e9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195541","predicate":"biolink:affects","object":"NCBIGene:27334","sources":[{"id":"urn:uuid:55c5135b-a675-4a45-a71b-c67757ea0c1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2917","original_object":"UniProtKB:O00398"}
{"id":"096fe70d-10ff-4b59-9e44-d3319cc74b11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:26361095-f85b-4907-abf0-cbf226c9bc07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:P22002"}
{"id":"ec321667-0b2e-4b8a-9f98-8736400988fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94306","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:2b198fb8-5712-43aa-b3b5-53e39807e4f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9664","original_object":"UniProtKB:Q92769"}
{"id":"abbd9f14-b831-45e1-b22b-aa770843910f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1471","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:05f974bb-0f18-4580-9482-0896ec64138a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1471","original_object":"UniProtKB:Q9GZQ4"}
{"id":"ab99ed01-353d-468a-98ad-e315c8a41e76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:cd3ba8dc-189d-4b01-a8a4-d3b4c8f3efde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P28221"}
{"id":"30c5dd96-8ab0-4666-89e5-8b16373564f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NT43S9BKJ2","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:40a01245-4e4e-4aa7-bdc1-a5a282b250db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8870","original_object":"UniProtKB:P41146"}
{"id":"ab1a8229-44c1-45c2-b153-e7ff19f1d966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:e25aa843-f3a2-4a3e-ac53-8aaf1d9f995b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P08909"}
{"id":"4361db4c-6de8-4f41-be81-b170035773b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23725180","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:f57c4a5e-241e-4179-b88e-f64a2388ceec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11597","original_object":"UniProtKB:P51681"}
{"id":"29da81e2-142c-46ab-a8b9-822ad320ccd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25067576","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:1f8b1753-ab2c-487a-9032-9b98cb3db042","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3219","original_object":"UniProtKB:P28222"}
{"id":"ea5812c4-9dd1-43cc-b9bd-a8b08fffe8ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162524593","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:f337a982-3f38-406b-9cd8-ddba7b77041c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11946","original_object":"UniProtKB:P09874"}
{"id":"101e2572-4f19-4bc6-b68d-1d5fc2673285","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FB39E94UXK","predicate":"biolink:affects","object":"NCBIGene:23945","sources":[{"id":"urn:uuid:47c88984-ce0e-4ba4-ba8e-8f8b2adac05a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10062","original_object":"UniProtKB:O35678"}
{"id":"527f1daa-0300-480c-bc5e-c189eca737cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3500","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:45dafe29-4c17-4ff8-8aed-a469d693b04f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:335","original_object":"UniProtKB:P20309"}
{"id":"6bea2ec1-4f95-4e21-ba0a-581bbcfea8e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4869","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:95271d3c-2991-4371-ae66-bf2b5ec14449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4869","original_object":"UniProtKB:P16066"}
{"id":"592c4c82-6f04-472a-801c-a459d36a144b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46830215","predicate":"biolink:affects","object":"NCBIGene:29904","sources":[{"id":"urn:uuid:444d7b4a-650c-4dd2-b97c-964d7753bbf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8743","original_object":"UniProtKB:O00418"}
{"id":"4a008533-e293-4ef1-93bd-dc27ac154c58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177387","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:23212b68-3212-48a9-93ba-38cc8cd8ff66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7406","original_object":"UniProtKB:Q02127"}
{"id":"f79f7efc-f05a-4113-91f0-7519b455f305","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L1Q2K5JYO8","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:9365a63f-0530-409d-a89b-f0006916fc17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11672","original_object":"UniProtKB:P00533"}
{"id":"a1e8d50f-b47b-448c-9c76-54424bdeecba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2734802","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:2ef30dea-4939-4536-b5b2-5e682bcd5cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9631","original_object":"UniProtKB:Q9BXA5"}
{"id":"5d62bf77-8c73-4b5d-a531-ea757d1dd243","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134677","predicate":"biolink:affects","object":"NCBIGene:5136","sources":[{"id":"urn:uuid:060c89c7-b5d7-4a05-b9c3-94682cf50434","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9151","original_object":"UniProtKB:P54750"}
{"id":"119f6e59-70d8-4531-b1c5-def37f01cbb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51346816","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:8ae9286b-5e32-4841-8d42-b793e70158c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5724","original_object":"UniProtKB:Q8TDV5"}
{"id":"ee7ba924-9eba-4784-b344-686cf5c459ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:727787","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:c1a5477c-95db-48d3-a20a-1b78e8f04005","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6268","original_object":"UniProtKB:P25090"}
{"id":"829c980e-cf38-46dd-9fb4-a3f23e616c18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56650312","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:b3ad9abf-0257-4b79-b3d4-67198c2f5320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7500","original_object":"UniProtKB:O15379"}
{"id":"09961840-1a98-479e-9809-c57194f50c39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10095126","predicate":"biolink:affects","object":"NCBIGene:81681","sources":[{"id":"urn:uuid:df48e4e8-114d-45f3-a4bf-a4e2e51a8505","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6720","original_object":"UniProtKB:P48450"}
{"id":"49aef8d5-ec87-41d6-8d06-0e191c1c3716","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E1V875I8DX","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:55f581b0-181a-4ebe-a1af-414ed684f60c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6057","original_object":"UniProtKB:P17948"}
{"id":"f37d061a-a6ce-4eb2-87b2-ca749db3cb36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45263291","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:70622244-f4ee-4906-8726-e496359b2b31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6727","original_object":"UniProtKB:P17764"}
{"id":"3b0abcf6-5fb7-4d29-b3a4-2381791d20f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122163152","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:c1d7b87b-b55c-4b94-abb6-8d41fd29316c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9571","original_object":"UniProtKB:P48736"}
{"id":"5efe2512-fdb2-445b-9990-781068a9ff10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:4aa86e8c-d0cd-4b58-8be9-c382cb61ed04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P45984"}
{"id":"3d514f13-ffe4-4bfd-936f-1c33e6aee79f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:e15482d4-b4b6-47f0-a98d-8b6f9c994b93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P28566"}
{"id":"b99268fc-f8a6-4b02-ae16-904ad3ea7185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:7d383fb4-e449-4cb3-bbe6-1a01c98331f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q13547"}
{"id":"344aaf13-7def-4f49-a2b2-faff23cd2cab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:3d9d28b0-ed3b-458d-be93-a6911f710ac3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P29274"}
{"id":"e779748f-743e-4fd5-a028-8f650a5652b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12347","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:9bbda648-f82b-4547-b301-0b138e8dcd5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12347","original_object":"UniProtKB:Q15116"}
{"id":"ca6e9a54-b4f3-4faf-a4ce-35a45d872f0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:776","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:33bce254-6315-48d2-95e4-bf41dfafffe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:776","original_object":"UniProtKB:P41597"}
{"id":"873f8b89-ccdf-47b1-9ba7-e8a82c35a88f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3DGD69C6PV","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:7267e97a-1768-465f-af20-1e5ee2bf6097","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7741","original_object":"UniProtKB:P06213"}
{"id":"8255b742-0e65-4c6b-a2b9-142f82520aca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104872","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:e66d89af-13d9-4430-9ee9-5f0dde4a14bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5260","original_object":"UniProtKB:Q08493"}
{"id":"037d30ed-6f22-4487-aaa8-8b9639a72e3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132086","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:e75dfada-9a60-42c3-8451-ac6e20dd3c9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2641","original_object":"UniProtKB:P10826"}
{"id":"791ff8bb-2fb9-4b93-89dd-812eb09dcbbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7NL2E3F6K3","predicate":"biolink:affects","object":"NCBIGene:2158","sources":[{"id":"urn:uuid:8abc80b0-a801-4cd3-87bd-8b1c514d4c4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9744","original_object":"UniProtKB:P00740"}
{"id":"0960cdfc-a485-457f-9225-d3e052180b1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1996","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:67994bb1-041e-4fce-b8ec-72720f4b9ece","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1996","original_object":"UniProtKB:Q8WXD0"}
{"id":"3f72d5c0-a303-43e1-8535-56addacbdb44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5103","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:743c6d59-c7ba-4320-ad78-e246928d72a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4192","original_object":"UniProtKB:P14867"}
{"id":"7d393b9d-afa6-4846-a413-c4257bd53bbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659803","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:27af6001-eafe-4150-9587-a5c78b632710","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6338","original_object":"UniProtKB:Q13255"}
{"id":"e6ad0012-590d-4684-a25f-cc2c56370068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82700","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:63f9787b-c67f-4a79-a210-728ac460969b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7543","original_object":"UniProtKB:P07550"}
{"id":"965c54eb-79a3-4621-b26d-cb14c05a6911","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80312","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:23bd9c67-a0bd-4404-ab5d-7e8e3dc849eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2090","original_object":"UniProtKB:P25103"}
{"id":"def3fada-a10f-4be6-bc4c-e6ec48dc6a2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16136126","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:46379437-116e-4b89-bf09-1c995840ff82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6246","original_object":"UniProtKB:P25090"}
{"id":"6f81c2bd-9f24-41c1-972d-cac5b9887729","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:0deb8319-f192-4410-a5d5-291be3a1e522","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P28335"}
{"id":"6af75623-2999-4223-b9b7-d9d6b9cb9a5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3223","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:a8953cee-05d7-463c-8f6b-fb54ee70d0f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:36","original_object":"UniProtKB:P32304"}
{"id":"65beda0b-96c6-49a2-add9-a1a8c16f91ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45378170","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:21589fbd-f91d-413c-aa9f-434976791426","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12616","original_object":"UniProtKB:O00329"}
{"id":"de56031e-3df4-4cae-8d98-8246abd75fe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:81b2edcf-7f86-4fe3-9ef0-60d50f7968e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:O15554"}
{"id":"db4071ae-1479-466c-b237-a226b1650fdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:c1d41610-0f1b-4850-9855-da9fd3c0cc40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:O60674"}
{"id":"8989a374-f82c-427f-ac28-498571047cbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168429725","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:ca8901e4-2de5-44dc-a982-bed2ffb9c6ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13383","original_object":"UniProtKB:P47871"}
{"id":"dc746aab-62dd-407f-bcf3-443175684db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:444007","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:caac12b2-d52c-4dd3-acd9-645ce39e0154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:870","original_object":"UniProtKB:P30551"}
{"id":"9de8540f-c85b-415a-9563-34d6f6fade35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:af506de8-5890-474d-a84d-93a51572c8d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q92769"}
{"id":"2798e0d5-1958-41c4-810a-92a14c10b055","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2036","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:049b3aa1-7637-4dc5-8c42-b16f13474a5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2036","original_object":"UniProtKB:P30874"}
{"id":"ada22f10-4341-42f4-b158-5501b338bffb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6E68796C40","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:f79e85c7-e0d6-458d-be16-0dfc4e4f6782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5593","original_object":"UniProtKB:P0DMS8"}
{"id":"98edfafb-008c-4b0f-bad6-7915e2bdf084","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L4C1UY2NYH","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:e2e5df09-2105-4ee7-8ab9-d8ee4bf7ccd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9636","original_object":"UniProtKB:O00329"}
{"id":"2aa30ceb-06af-4afa-8794-2f41f982dd73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5288811","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:b88e28df-451c-4d8b-ab60-0ea71aac9d3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3980","original_object":"UniProtKB:Q9UGM1"}
{"id":"8cd88fec-5d7d-49be-b9fa-33e65d719036","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231364","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:ee77c9c4-653e-490a-8c81-3706398a3846","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7934","original_object":"UniProtKB:P11802"}
{"id":"01f5bd5f-0bd5-4e8b-b4a4-9d6c72dede41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:bafbfc26-3302-49bb-8fc3-2811c11aefe7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08173"}
{"id":"1ea21798-8039-4db7-a55e-40ca8ea182ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9864550","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:bbacb0d7-cc7a-42b3-be0a-1116657a7f7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4332","original_object":"UniProtKB:O15399"}
{"id":"4a703f88-12b6-40e5-b4ab-5ca99a3af0c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:d549cb41-6d42-4e15-8e42-528066ee9819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P30994"}
{"id":"5e443f39-8c38-416d-94f9-aba7971374d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1798","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:783aff39-66d3-4475-b7e3-32a91f13ae4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1798","original_object":"UniProtKB:P49190"}
{"id":"8a077a61-49d7-49a2-b433-7d793357fd3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167653","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:8a4ebf9f-7a0e-46fe-92cf-7077e7f3e88b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7706","original_object":"UniProtKB:P08069"}
{"id":"cb6b0864-dec3-4ff5-8217-6e75f3a39892","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1868","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:0d6eb127-f3c6-41be-99cd-109efc7630f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1868","original_object":"UniProtKB:Q8TCW9"}
{"id":"cef5da0e-6418-461b-a446-ce236417eeee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136218973","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f7639a23-2a20-413b-9e9a-40ac9c166669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5590","original_object":"UniProtKB:P29274"}
{"id":"b9f4fb65-0fec-454c-9588-5cd18c902660","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129679","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:b74e299e-0a91-4bdf-891c-683dc11e1aa7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1152","original_object":"UniProtKB:P41587"}
{"id":"0fc04b3a-d332-4202-b8b9-c65ba111f5cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135899","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:f4733504-8c48-4bdf-bf31-0bee5344f2cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2213","original_object":"UniProtKB:P37288"}
{"id":"28433ce8-0726-4d96-8cc3-2bf3c1a13709","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165437862","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:b6ffecbd-b0f0-467c-952b-d0c9bdbb754a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12248","original_object":"UniProtKB:P08581"}
{"id":"e526c645-9094-4b14-b378-dabf79dfc0c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:765","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:6085254b-0e98-41de-ad29-a3efc961867e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:765","original_object":"UniProtKB:P51677"}
{"id":"c76b2439-aac9-4a47-a55e-8995d3898f8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129320519","predicate":"biolink:affects","object":"NCBIGene:3551","sources":[{"id":"urn:uuid:b272241c-958a-4612-bfe4-6ce2842f7c2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9646","original_object":"UniProtKB:O14920"}
{"id":"ce718558-476f-42bc-9efd-44c3a1959782","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25207521","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:ab73a6af-f99b-4604-b4c0-fef040527ea8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8163","original_object":"UniProtKB:P49137"}
{"id":"86ba99aa-425e-4403-9baf-2520862694a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WV82DEG4YA","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:c525b3ca-d8ed-4991-8d6e-7c30f12de4d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10279","original_object":"UniProtKB:Q9Y210"}
{"id":"6d637e4c-ec70-44ba-9605-7ca6d1e4e501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z80293URPV","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:0ef9a2f6-769c-4ec9-8ff2-4b70f7c75184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8709","original_object":"UniProtKB:O95977"}
{"id":"8f40a7f2-e4eb-43be-a010-850bac172f3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8L3B1I6V2T","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:65c02a2a-b57e-4bee-b37e-a217c1398808","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5741","original_object":"UniProtKB:Q8TDV5"}
{"id":"fc4de300-2ef7-4b90-94d3-eea2997c2000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6TLR8U8O3C","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:148b6925-0b90-4bef-99ee-eb6e0a8c4534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9919","original_object":"UniProtKB:P04626"}
{"id":"8f434987-88fa-4185-a976-353b27de856a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132992142","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:ee05f64e-3d34-4c83-b9f9-af4fe670ee5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9929","original_object":"UniProtKB:P07947"}
{"id":"27e0e209-300d-4ca3-b598-1f46697336a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946376","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:e097b0a0-83fe-4abb-9b81-4b109c5e3e9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13156","original_object":"UniProtKB:P25100"}
{"id":"ca938e3a-72da-4163-847b-697e27c46081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44623954","predicate":"biolink:affects","object":"NCBIGene:9293","sources":[{"id":"urn:uuid:45b1e846-bafe-4146-bd47-150b3de362cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8840","original_object":"UniProtKB:Q9Y2T5"}
{"id":"20d21308-5395-41d0-b9a4-9fcb0334624e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1310","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:01c8b59b-aa49-4bd6-8285-73a4a2213307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1310","original_object":"UniProtKB:Q99705"}
{"id":"1ff567d9-47ac-4bdb-be6b-409b3c074b63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:21602555-a1fa-4133-a355-044bd718fbb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:Q8NEC5"}
{"id":"5121c5b7-83c0-43cd-b40b-08882e1799b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91556","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:3e68f0b7-913a-4507-86cc-dcb3c1e3e778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:161","original_object":"UniProtKB:P28335"}
{"id":"b1fbdb40-3546-44f0-b4b9-f914d2948718","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53252525","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:53b5b2e5-09dd-4f24-b7ae-2cb68794032f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6395","original_object":"UniProtKB:P41594"}
{"id":"a9604c04-04e6-4a96-a61e-42ae1fd239b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:f52ecfda-998b-4641-b2a5-fd47dc2b9581","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P21917"}
{"id":"b316abb6-97e8-497a-9b12-aaa68d36cd96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46937420","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:e188b4b4-5bf9-4df3-bf9a-c725fcd10dca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6260","original_object":"UniProtKB:O88703"}
{"id":"e3e576ac-4e49-4f2f-bf70-5601c83d8da6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109533","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:10fbc1f3-4535-43fa-9bf3-c8c496299599","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:62","original_object":"UniProtKB:P32304"}
{"id":"fbd74dda-9dd3-43d1-9281-599c764a9fcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P85X70RZWS","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:3287f11b-81c6-4f5d-9857-bfb390436fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10773","original_object":"UniProtKB:P48169"}
{"id":"b378c4de-c37a-457d-87a7-badf23c73ff3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11247965","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:f68b850f-de9e-45d8-9200-ee9453da97bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8890","original_object":"UniProtKB:P00374"}
{"id":"b86fcdfa-9abd-4956-bb75-b4b97f18b50d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BTS1Y6777M","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:d935056d-3b50-466f-813f-d5113f9252ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3290","original_object":"UniProtKB:P0DMS8"}
{"id":"4c11862d-d4fe-4122-87a5-772d047c5503","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94302","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:318b812e-cf0a-4210-bb71-030bc85de865","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8011","original_object":"UniProtKB:O00329"}
{"id":"333f09a5-d513-4180-a46e-23895c65da1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6U9WP10T7","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:329105c5-2045-4d1f-b600-d371963ddcb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7885","original_object":"UniProtKB:P36888"}
{"id":"1717eb40-28d2-4432-af75-915f2768c72d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73010930","predicate":"biolink:affects","object":"NCBIGene:29994","sources":[{"id":"urn:uuid:17958429-6fb3-4668-968c-fd97b37d06f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8233","original_object":"UniProtKB:Q9UIF8"}
{"id":"9fa5fc3d-e9c4-434e-bcd4-63c58255cfa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Q9O54P0H7","predicate":"biolink:affects","object":"NCBIGene:11309","sources":[{"id":"urn:uuid:299eacfd-0b31-4975-b572-3e85f5895c30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6193","original_object":"UniProtKB:O94956"}
{"id":"e38c2076-e304-4be8-a8d7-4bfb640c731b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60195125","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:bada19f5-a0dd-4055-9e74-e91b73d37f0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9149","original_object":"UniProtKB:O14842"}
{"id":"bd71113f-9aa5-45a3-87d0-f12f65cd4cf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51913","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:d750537d-645d-457e-a7bf-e99292a0b460","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5973","original_object":"UniProtKB:P36888"}
{"id":"32debcc1-f0fd-484f-a530-48a2bb555fe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:78c930f5-0ed1-4feb-88ca-6a390d8d57d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:P25774"}
{"id":"0053df9d-c5a2-4358-a0d6-61e75ce7a380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494540","predicate":"biolink:affects","object":"UniProtKB:P0DTC8","sources":[{"id":"urn:uuid:ee2f4d59-93d9-490f-9ec0-6e32052d36c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13635","original_object":"UniProtKB:P0DTC8"}
{"id":"c7decd08-2d35-4b60-ae7c-9f461f822a40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134764","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2e6df344-ccaf-44c4-80c3-b5a3afc2cdda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:299","original_object":"UniProtKB:P08172"}
{"id":"a1fb121f-404e-4ea4-9553-366705a61dad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49843739","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:2e502c69-7982-4bfe-ae88-c5ad0215575b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8867","original_object":"UniProtKB:P41145"}
{"id":"de953b24-88e8-4b0e-b633-08fcd5578322","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6BTT8VA5Z","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:3c0ecd5a-3d16-4f8e-9cdd-3d75075f8b04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4460","original_object":"UniProtKB:P56718"}
{"id":"cb48b828-000c-4b0d-9e73-5ea821da505c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63453","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:15d290a2-2c0f-44a8-b61b-a95ea03beec2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7707","original_object":"UniProtKB:P11362"}
{"id":"3cc1f101-b833-47b3-9ca7-906fd0a516bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321169","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:74f5e440-1416-42c3-94cf-143562d06aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10198","original_object":"UniProtKB:Q8TDU6"}
{"id":"294e62c2-1f59-4506-a39d-2930f5aa5e3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL413188","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:387885d0-b10a-490d-bfd9-82776fde4d47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5991","original_object":"UniProtKB:O96017"}
{"id":"58478ebc-3a74-43d3-a6e5-ac21306b15c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:756","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:8b9a3291-25b9-436f-908b-a550ba2d8450","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:756","original_object":"UniProtKB:P32246"}
{"id":"245a11b3-0bb3-4679-8a5a-ffb06fc11ce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1099","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:f7c2cc2f-439c-47c9-947e-88d81bdcbd6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1099","original_object":"UniProtKB:Q92847"}
{"id":"ba5b2cfc-d28d-4226-8f9d-865aeff0c349","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3780244","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:fb1d139c-44a2-416e-b243-febdd64f5c60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9314","original_object":"UniProtKB:Q92952"}
{"id":"c491de02-a0a8-4eba-981f-d8d181377e0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5547","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:30d29013-a060-4c7e-b198-44351929687f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12468","original_object":"UniProtKB:P59540"}
{"id":"5405d6bf-f73c-4c2a-b24f-0a5c763403d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37850","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:d9986907-be2d-452f-9c2e-a8bd710a723b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2459","original_object":"UniProtKB:Q8TD43"}
{"id":"eeb07d22-f8b0-4f2f-b2c0-3dea46749992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151782","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:eb2d9864-ecf7-46d3-acfb-f95e4f8d28fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13180","original_object":"UniProtKB:P08913"}
{"id":"49de01f1-f293-461b-8445-67eed03c072e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4324","sources":[{"id":"urn:uuid:333e62ca-754d-4bbf-b911-46c44f0b88f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P51511"}
{"id":"fc3ea5f5-15da-418e-9c41-330a6b4f36d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7494","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:9b3fc86b-41cf-40ac-82b2-d3380a89d14f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7247","original_object":"UniProtKB:P31645"}
{"id":"b8efc617-a42b-4d60-8eda-2c05660aafec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:39aca8f6-3a1d-4f76-b13d-ee400ea509d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:Q5S007"}
{"id":"d251026a-e13f-417a-85ec-6a1f4a0da66f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1093278","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:2e7a1e3b-a25d-4442-9b4a-f150918e7972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8369","original_object":"UniProtKB:P14416"}
{"id":"0bd68e65-7493-4241-b5de-2399289714c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:65459349","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:f110ec88-ee71-4f70-b73d-3df292ad54d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11864","original_object":"UniProtKB:Q12809"}
{"id":"f8e5c731-7d20-4ab4-9ef9-4eec8b94cd6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92874","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:4c489d28-61a3-4ffd-8c70-482f34ee0a01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:966","original_object":"UniProtKB:P21917"}
{"id":"0fbfbf03-9196-4145-8f6f-38fd5ca7e240","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755220","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:90185195-e6a3-4db0-9b64-84ceff709685","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6430","original_object":"UniProtKB:P41594"}
{"id":"6b073ae6-d0af-4755-aaa9-703566afcee4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138634054","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:3f31b5c3-c619-461e-8d51-e1de142dd855","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11159","original_object":"UniProtKB:P30411"}
{"id":"62b5e3c3-0e66-470a-ab91-6ffcba045db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N5LJ2Z26C","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:c1f36d18-6875-461f-a831-d6046f07203f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6977","original_object":"UniProtKB:P52333"}
{"id":"bab91867-b82b-47f9-97f9-2f9ce152d0a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PI470C66NT","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:daf4095a-9728-40ab-befc-5ee4f4ad1d25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3544","original_object":"UniProtKB:P43220"}
{"id":"7cd0f679-e113-43eb-9864-68c4c4329643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137628676","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:447f6973-e055-426f-a936-cbdb49fe13bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12554","original_object":"UniProtKB:Q9HBA0"}
{"id":"45c6cd7f-3180-4446-b4f0-0475064f9827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52140","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:c4bb2f82-c2bc-45ca-b89f-867b9c20c457","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10285","original_object":"UniProtKB:Q13507"}
{"id":"3652b80f-36ac-48fb-9f6d-7d7617841c9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393294","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:171bafba-55c9-49a6-ab04-76beb869c5bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10402","original_object":"UniProtKB:P00519"}
{"id":"272990d7-2b85-495d-b908-50633a258389","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:eb2ad648-830c-4437-b1e9-6dffec736b5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P31388"}
{"id":"5d95948d-47bc-4f1a-93c8-5f367840ad7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755100","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:3ee17e75-7284-45f4-a793-60b4d202abea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4598","original_object":"UniProtKB:P48067"}
{"id":"3e92f380-fc4a-4510-9155-71dca086c052","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44584947","predicate":"biolink:affects","object":"NCBIGene:5046","sources":[{"id":"urn:uuid:4835c58e-62a8-4642-a3f2-8a3dd6cd273f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8668","original_object":"UniProtKB:P29122"}
{"id":"07d7cb59-7ac4-471a-8c6e-7251d672498e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8631","predicate":"biolink:affects","object":"NCBIGene:12145","sources":[{"id":"urn:uuid:a8b77102-1bee-44ac-94dc-61de1d586f59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8631","original_object":"UniProtKB:Q04683"}
{"id":"78f2c460-c326-4eb1-8f40-97193a697b75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:16515","sources":[{"id":"urn:uuid:ee6b9983-3a9f-4dcf-af8a-b73ff4493e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P52187"}
{"id":"1527343a-8095-48d0-8a1d-8e02dcae964a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:226ec06a-73ae-4340-b1ec-2235fe426934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P06213"}
{"id":"1ffa9096-1a34-44c1-aeb5-a4647188eea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13891","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:51cc0ed8-58eb-49f8-b1b6-d4cec9f07270","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13891","original_object":"UniProtKB:P35968"}
{"id":"84a5502a-eef9-48ea-9054-502b13c3eeec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:c70cf166-78fb-4ebb-8a67-15892a993726","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:Q8BLA8"}
{"id":"326f51ec-dc2f-4d36-a627-88a7e440d672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:22068","sources":[{"id":"urn:uuid:a9a50ed3-f70a-4a5f-a86e-752f0f811905","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q61143"}
{"id":"6728ba6f-6cdf-4926-814b-ed7ce1c31672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9885773","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ee512b88-a951-4467-9a02-99d693cdf26a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:471","original_object":"UniProtKB:P0DMS8"}
{"id":"b30079c4-630c-4b0a-a6b2-c1381abfe5ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:3ba0c2e9-7d4f-4e0f-b18a-4d4af436b6c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P31388"}
{"id":"eb823002-0195-47cf-89bf-3e663a9e46fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3699","predicate":"biolink:affects","object":"NCBIGene:146802","sources":[{"id":"urn:uuid:4d7c299e-5bf4-4fac-a29d-6266901f3aa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1231","original_object":"UniProtKB:Q86VL8"}
{"id":"b3155611-2e27-4ac4-82c2-8bb087f996e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:4128","sources":[{"id":"urn:uuid:3708a144-b746-40f7-98bc-beb317fd31df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:P21397"}
{"id":"f55c3be5-c2f4-4a5e-ada0-6ebba6bf3827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164712","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:512d0bee-c334-4ee1-b142-84c369e704c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2178","original_object":"UniProtKB:P30518"}
{"id":"15d3e84b-1a45-4d0e-825e-67fab808a56a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345449","predicate":"biolink:affects","object":"NCBIGene:3762","sources":[{"id":"urn:uuid:08b03b3c-2306-4e82-80be-c1148351f8b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7704","original_object":"UniProtKB:P48544"}
{"id":"dfe82860-0d9c-4c5d-b502-6ef7b8756000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64093","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:561bea45-b4cc-4e1b-b9b2-b81ffee55ee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4639","original_object":"UniProtKB:Q01959"}
{"id":"b3184c61-1e29-4ae3-92f6-1fa185e856f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TE53TU0WSQ","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:f445f93a-2f96-4a31-906f-729923da0a89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12788","original_object":"UniProtKB:Q03431"}
{"id":"291c4f82-9eeb-444d-b158-51f6ae769513","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126714060","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:08632a5c-c423-4786-bc41-90aa67f4ea6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11901","original_object":"UniProtKB:P04150"}
{"id":"8bd9a5d7-06fa-4d7d-aaf9-3740d7fff940","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134774","predicate":"biolink:affects","object":"NCBIGene:6565","sources":[{"id":"urn:uuid:0341c2d4-d0e9-4790-b7fb-604626ba9c74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4702","original_object":"UniProtKB:Q16348"}
{"id":"4b833af6-c117-4698-8bf0-a8390858cdb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699458","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:8d4af01b-a1ae-4d92-8e07-2fb0376d56d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11197","original_object":"UniProtKB:Q9BXC0"}
{"id":"f10137df-f205-4e1b-8278-2b4c19f8ede8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:4c7a09e7-e02e-450c-936c-3e474a479bcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:Q9UQB9"}
{"id":"224eab0c-fd16-4423-8834-b28d5e066a57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231353","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:4ae794e8-a7ae-4e0a-a503-f5c0b9b84ad5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13853","original_object":"UniProtKB:P05093"}
{"id":"177b32a4-00e0-466a-af27-5e37f144ab63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16618023","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:45c230c7-44d0-4664-b4b8-f9e90edb82cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10372","original_object":"UniProtKB:P08183"}
{"id":"46abc120-70a1-4fc8-86cb-60f81ab3baf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:2846","sources":[{"id":"urn:uuid:355e0e82-864e-4e5a-ad80-b14438ca5fbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:Q99677"}
{"id":"4d00e8a5-3dec-4910-ad33-53462ea0dd50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17447","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:3f93e4fd-3b34-4c65-873c-a9b5128125b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2467","original_object":"UniProtKB:Q8R4D5"}
{"id":"25b40a27-e64c-47ed-9a94-6911e3ff10b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:c9c0436a-8c50-451e-9023-6726432d86ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P34980"}
{"id":"da1daade-9cb7-466b-b69b-53410509b71d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:12Z0SU967A","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:e07340aa-9c38-40d8-a4b6-f096de2e7303","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1935","original_object":"UniProtKB:P43116"}
{"id":"1e0e504e-2534-4417-9be2-3cc202bfc74f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93578","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b533d0a1-4d9a-43e7-903d-8567f96df725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:42","original_object":"UniProtKB:P08908"}
{"id":"309a5d94-b022-4231-99ee-2410d9ce4dc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C6RWP0N0L2","predicate":"biolink:affects","object":"NCBIGene:1457","sources":[{"id":"urn:uuid:ebc81b1e-d82b-45d6-8ed7-290d2c1fd859","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8126","original_object":"UniProtKB:P68400"}
{"id":"b4cc6c6d-b659-4964-a7d3-641add1cddd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131351","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:2cf68617-fb2d-454e-a52c-e3e9e76f747c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:384","original_object":"UniProtKB:P29274"}
{"id":"affb71db-1f0d-4b41-a9da-c28268926b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10034108","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:93e6cd77-6080-4bd2-bee3-1c0d5ec599e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3765","original_object":"UniProtKB:P30411"}
{"id":"485a0aa7-7597-4206-888b-7e097e4b888d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:a14d60a4-17d3-4362-b1e1-388d32664897","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P30938"}
{"id":"dc0e52db-22c6-4025-bfc7-21531ccb35d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135125140","predicate":"biolink:affects","object":"NCBIGene:3418","sources":[{"id":"urn:uuid:6ecb868b-b0dc-4833-bc0b-ede7a520a438","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12340","original_object":"UniProtKB:P48735"}
{"id":"f28e75cd-6ffa-41cc-988b-fc9cabcdf3f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9290","predicate":"biolink:affects","object":"NCBIGene:56963","sources":[{"id":"urn:uuid:df522c23-559c-4226-976d-17bafd5daed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9290","original_object":"UniProtKB:Q96B86"}
{"id":"d7e3fd54-3b83-4e27-904d-48b5a2ed4617","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79700","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:390f43a5-30dd-4bd4-ae1c-be47526ad68f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7884","original_object":"UniProtKB:P42345"}
{"id":"7e7e4202-68e7-4a54-a15f-122b18f692b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:19222","sources":[{"id":"urn:uuid:4c71573e-183c-4ef1-93b0-32f213be045a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P43252"}
{"id":"ed1fb4fa-cb40-4c8b-a847-75c668ba4916","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10430549","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:52feab22-01f5-4f6d-b4fe-800e9a0efa85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2929","original_object":"UniProtKB:O95977"}
{"id":"f7692cd1-dacb-4141-929a-71f1e2cafc61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4067175","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:ec9071d4-693c-41e5-9504-fcffca068c21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4067","original_object":"UniProtKB:P28476"}
{"id":"1e702d7c-169b-4884-ba1d-cccc1c080423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135169285","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:2e205425-372a-440d-9228-55fd80e2ad26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11956","original_object":"UniProtKB:O15393"}
{"id":"35be91a7-05b1-476e-b09c-f93b4ca53778","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91378","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:f9db2694-3219-41e8-8808-680e2f813bc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10095","original_object":"UniProtKB:P06493"}
{"id":"c86e406d-6aef-4700-9a32-99ff8241c0d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4582651","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:7c4eefe1-cba6-453d-88c9-4b9b39154f52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10033","original_object":"UniProtKB:P35968"}
{"id":"fb42e906-0b7c-4ffc-aedd-1fb7489e405e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71957","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:f300ed6b-5a13-4aa4-881a-c8ee4c030a8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7963","original_object":"UniProtKB:P42338"}
{"id":"e5c3fe1d-cedd-436d-8784-911600238c26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73294","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:cad49a90-85cf-4a0e-9894-2436ffb9b58f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:676","original_object":"UniProtKB:P30411"}
{"id":"587858e6-7e92-467c-b32e-51bccb4819cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166822065","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:6b3203c4-7d71-4076-9032-537ec370ee2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13065","original_object":"UniProtKB:P42336"}
{"id":"0b6d7efb-f63e-4af3-a382-4a98d18145ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:574ed318-e652-4ca3-a762-afbea01a6d46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P21728"}
{"id":"de1b4f90-2f60-4d15-8fae-f6f536a48a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76649","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:0b3a25cd-faae-4874-9f09-b8bd779b6cc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:925","original_object":"UniProtKB:P47866"}
{"id":"443c0891-dcb5-4729-9921-356a2a88a113","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:8ac878f6-94bb-4399-982e-744ef4d15d1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:O14757"}
{"id":"ba34a425-bf63-4d77-ac51-c90baca6e60e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:65UT4V5Z34","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:042c0c92-4115-4c67-8133-f2f319d09062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:348","original_object":"UniProtKB:P20309"}
{"id":"d20be941-77ec-4261-abb4-ca899308d08d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50693","predicate":"biolink:affects","object":"NCBIGene:5140","sources":[{"id":"urn:uuid:c377bdac-fa96-4cdc-ae80-cb6f79743b8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5225","original_object":"UniProtKB:Q13370"}
{"id":"9536b82f-2a9b-483a-b274-fc20cffbddfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23786508","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:14c880e6-958d-49ba-bfd4-125522acb9d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:231","original_object":"UniProtKB:P28335"}
{"id":"46b2cfa3-9516-4b3e-abef-bf2b0c766744","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50911934","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:864d5645-fbc5-43c5-8f20-0db9d0f32c40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10309","original_object":"UniProtKB:P21453"}
{"id":"c51abc1e-b6e8-4ce0-ae78-057b3bd3c14e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47780","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:8f088519-4bab-451d-afa6-9aa9627c1e8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2398","original_object":"UniProtKB:Q01959"}
{"id":"74949a72-83eb-4886-a4e1-606f2dcbc146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11762","predicate":"biolink:affects","object":"NCBIGene:2615","sources":[{"id":"urn:uuid:f9f4c864-c773-4185-8129-b83b3b74c635","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11762","original_object":"UniProtKB:Q14392"}
{"id":"9d3dc53c-ce19-4d26-8933-85d184d1c560","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1246059","predicate":"biolink:affects","object":"NCBIGene:4851","sources":[{"id":"urn:uuid:0096bc92-4912-45b5-b32e-3bd5619329b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11362","original_object":"UniProtKB:P46531"}
{"id":"046cbf1b-8956-49cd-9543-c4babf8a9172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3XVL385Q0M","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:1cbadb2a-e967-4333-ac2d-47c2612650e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7913","original_object":"UniProtKB:O60674"}
{"id":"fe6ad82c-68fa-49aa-b79d-de3e2fb3d27b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:38d27a9a-5a5a-448c-b606-93cb70c09d95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q8K424"}
{"id":"05c4f708-c661-4153-9dd6-55d4864a29fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:f502783d-dd14-4e8d-b59b-b33599572b08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:A8MPY1"}
{"id":"c8ccd37b-078a-4b1e-875c-8e46599120c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17276","predicate":"biolink:affects","object":"NCBIGene:366","sources":[{"id":"urn:uuid:59a94260-356c-4d74-ade0-1afbcc85a6d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4285","original_object":"UniProtKB:O43315"}
{"id":"fcda9873-2460-49b9-a71d-72b520f7c941","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91645","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:be22dc7e-5204-420d-a18c-62ad98601016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12442","original_object":"UniProtKB:Q9NYV8"}
{"id":"1a3fa61d-f409-4c1c-ab0c-0dd8add212ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q3238VQW0N","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:a97a81af-3f6f-4c3c-8377-300bf315058a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7815","original_object":"UniProtKB:Q16539"}
{"id":"1e14e9fb-c537-4486-854e-daf724541e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821941","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:11d1b3a5-5b0a-419a-b8af-373d4ed3b883","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9099","original_object":"UniProtKB:P14416"}
{"id":"7ab5e450-d644-4542-bd2f-09ecf28bf73f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DE4G8X55F5","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:8bd48081-dd9b-47e7-b776-6fe7a9b4dc81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9194","original_object":"UniProtKB:P41145"}
{"id":"836c98e8-10c3-46c2-81b0-183b5fd3f0a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39548","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:e056824f-74d6-4e44-b1f1-2c0fb67b3d85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2949","original_object":"UniProtKB:P04035"}
{"id":"bcdd80e3-6b83-40d2-ba6b-b35763d544ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177605","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:6642ab27-c4e9-4f4d-ae2d-bc1f7b924645","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10651","original_object":"UniProtKB:P41143"}
{"id":"122113fe-76ed-4336-9774-462189a47c30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132484","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:68e5a3b6-3374-4f00-8c3d-ccb6b5891b1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11663","original_object":"UniProtKB:Q5S007"}
{"id":"485c3abd-e9f3-46ad-a43e-a628a2d2e122","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3048","predicate":"biolink:affects","object":"NCBIGene:340024","sources":[{"id":"urn:uuid:62c3f168-c4f4-4c14-a3ad-0fec425c0c85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7601","original_object":"UniProtKB:Q695T7"}
{"id":"e6ae3bf7-93b9-440e-bb6d-849e15e6fe93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CQ4M18RLJW","predicate":"biolink:affects","object":"NCBIGene:8694","sources":[{"id":"urn:uuid:046e0bf2-91cf-4c75-9dfc-1ad0b4d4cba7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7829","original_object":"UniProtKB:O75907"}
{"id":"0afee1c3-1275-4245-bb6a-389af739a662","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072549","predicate":"biolink:affects","object":"NCBIGene:65980","sources":[{"id":"urn:uuid:c7546514-8235-47dd-9974-a9894bc8cd29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8950","original_object":"UniProtKB:Q9H8M2"}
{"id":"4a2f0700-34fb-47a6-8ab2-c0c51209c2a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:dd3534ad-f51a-48f5-b63d-72ddfbbb3d8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P08581"}
{"id":"10ddcb3e-a823-457f-84fc-421176f4d260","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71462653","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:01eb8a2e-ce3f-4ec9-b40d-11ef131909bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7504","original_object":"UniProtKB:Q13547"}
{"id":"26f5a823-c6f9-4418-8044-6a9b3b062bfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34973","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:36a938cf-de8b-464d-ae6c-27bde27ff30c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4155","original_object":"UniProtKB:Q14957"}
{"id":"be5f491b-cd6b-4562-af33-5ff2bcffef0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73442760","predicate":"biolink:affects","object":"NCBIGene:9833","sources":[{"id":"urn:uuid:d48de7b2-f63a-4e09-9628-d77126cf7291","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9366","original_object":"UniProtKB:Q14680"}
{"id":"e91c6326-95ec-4d23-9860-a024e168715f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44975","predicate":"biolink:affects","object":"NCBIGene:54429","sources":[{"id":"urn:uuid:33ccfadf-3fb9-4d17-98d5-01ed2c5e6712","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12425","original_object":"UniProtKB:Q9NYW4"}
{"id":"1eb615d2-81bf-429b-9097-3d33916a31b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31547","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:383fd63d-8ba6-457e-b29a-bdf256d4bebc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2876","original_object":"UniProtKB:P08235"}
{"id":"610f5050-885a-4551-b969-97957fdce965","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132427690","predicate":"biolink:affects","object":"NCBIGene:5657","sources":[{"id":"urn:uuid:504ad64c-a875-4dfd-becd-b500e4733a78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9819","original_object":"UniProtKB:P24158"}
{"id":"d7c2f019-8eb3-4d41-a022-8f80947fc593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9582","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:cd142f9f-5f32-4eff-b062-580e2bffaa19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9582","original_object":"UniProtKB:P22001"}
{"id":"1e5c64bb-5577-4d00-9677-d81afc13befd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9825701","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:f06e45ac-16e9-4053-b794-64f3a78b2778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8907","original_object":"UniProtKB:P37231"}
{"id":"25596889-c16f-422b-a0e3-9dca631af31b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:8569","sources":[{"id":"urn:uuid:88194ac5-dcce-4b20-a1f1-7222136ebc86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:Q9BUB5"}
{"id":"8738dfa6-f694-4d12-bb7e-39f8195ceaab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J1J4P3PQZD","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:6217b36a-cb6a-45ec-831a-fd0e3fd98e3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6902","original_object":"UniProtKB:P30556"}
{"id":"b792647a-4c89-494c-a45c-b8e32fd1a04e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:61098089-b7a5-4ad3-bbb0-f739f644be22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"mixed_allosteric_modulation","original_subject":"GTOPDB:4366","original_object":"UniProtKB:P14867"}
{"id":"81f294f3-7fab-4742-95f0-92f6bf26f171","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44589122","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:53c53eda-a193-45a8-82fc-6c87c91bdba0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11815","original_object":"UniProtKB:O00519"}
{"id":"2d9b3ee5-a937-49c8-8bdd-b5b16ebf35cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:4593","sources":[{"id":"urn:uuid:f7bf72d0-8fee-4d01-a64a-d166272954a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:O15146"}
{"id":"e622c970-9833-45b2-be7c-c52021ed26d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:77c417d0-70c9-44c9-beea-d0944e15576b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P28223"}
{"id":"37ae3240-188f-45bc-978b-9edbccc09706","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34662","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:ba1b6044-0691-43be-a5b7-5f53a72dc315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2324","original_object":"UniProtKB:O15554"}
{"id":"04881169-f5b6-48e4-b7d2-88b814c0356c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:51347","sources":[{"id":"urn:uuid:8e851725-1a73-4a26-bd2b-ef929abee8e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:Q9H2K8"}
{"id":"a0513b7c-88fb-4376-925d-c5aa7272eb69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134585358","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:54ffde01-beaf-40d3-bd05-f75b9b9f166b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13387","original_object":"UniProtKB:Q99250"}
{"id":"11482072-4b8f-4846-a9ca-f00384efcccc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2247","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:25cbc7e3-8cf8-4bd5-8848-379d8b3a6ebb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2247","original_object":"UniProtKB:P30559"}
{"id":"9db02a59-3572-4c88-b81d-33d17645845b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VU7278D853","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:1010e648-bc2f-4d83-b8ae-e9b053411468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7667","original_object":"UniProtKB:O43526"}
{"id":"43ead92f-f0ce-41b3-9b43-36832fd836d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:eb7f0481-f08f-42e4-b9d4-63fca0d7946d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:P35375"}
{"id":"378a9ab8-60f2-45bd-a969-387678451079","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138455182","predicate":"biolink:affects","object":"NCBIGene:10927","sources":[{"id":"urn:uuid:071113d4-fd9d-4bc3-b270-f732018748a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13300","original_object":"UniProtKB:Q9Y657"}
{"id":"b8a4b84e-ecca-4308-b764-17978354c3fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155411202","predicate":"biolink:affects","object":"NCBIGene:84148","sources":[{"id":"urn:uuid:5036bb74-4fb2-4c76-a00b-261c76452527","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12938","original_object":"UniProtKB:Q9H7Z6"}
{"id":"fe981285-50da-44ab-93ce-4cca622ecab9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4A3702A96F","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:39bd0586-353f-4e0b-9fd5-2ec8e075b770","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10506","original_object":"UniProtKB:P21728"}
{"id":"e478ff06-685e-4432-bd1e-901549b6b59e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:be58fd25-dcd2-4662-8ae6-5ca4a3337011","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P35346"}
{"id":"56768dfd-b7a9-4c69-bac2-2345d74ca854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:41692fde-57dd-4b95-955d-2fd4c70e92d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P35367"}
{"id":"b7b157d2-23fc-4260-88b2-358b02ded5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:e1956a97-b0c0-43af-8b57-164f83235c0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9UL62"}
{"id":"9e2ca3ce-77c5-4082-903e-ea34bc44a62b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:035ca88e-b617-4a2a-a8d6-729818a88ec7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P33535"}
{"id":"24466fdd-b682-4326-be1b-b7052c0309ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2568","sources":[{"id":"urn:uuid:3b86f5a2-ed15-48fa-8a9f-4f37f2804f0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:O00591"}
{"id":"dbb30e89-7517-48d1-8e67-bdef5e66daa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:259232","sources":[{"id":"urn:uuid:d16f8f2c-083b-42f6-892c-fd68d2eb402c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q8IZF0"}
{"id":"50601494-b44c-4343-9ad3-c866c18925a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311007","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:f10d1487-b556-424e-bec3-99579d080e66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:739","original_object":"UniProtKB:P20272"}
{"id":"e9c7efce-bce3-4fcb-b895-e961c79459f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12502","predicate":"biolink:affects","object":"NCBIGene:381489","sources":[{"id":"urn:uuid:ce2a072c-6520-4bfe-b29b-3fb14546cf79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12502","original_object":"UniProtKB:Q6R6I7"}
{"id":"b1818086-2e9c-41ee-80a9-73f86c4b2f15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5062","predicate":"biolink:affects","object":"NCBIGene:6716","sources":[{"id":"urn:uuid:a187955c-c3f7-49fa-bfea-477343d87b46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6818","original_object":"UniProtKB:P31213"}
{"id":"f9cf0b23-a9da-47e8-b302-20131a95897d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:e93dfbf0-f7f8-4a31-bb90-f7d7167abbbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:343","original_object":"UniProtKB:P08173"}
{"id":"c8e38cb1-a471-4001-bdeb-ee34cd28e1fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34461","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:0ffc4f87-5b4e-4447-b098-69570e9e4274","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4321","original_object":"UniProtKB:P47869"}
{"id":"eea6e8cb-3d05-4484-b693-112b31bc2a86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CZP9GB25HO","predicate":"biolink:affects","object":"NCBIGene:4214","sources":[{"id":"urn:uuid:8434cffb-fae0-4985-a493-692582bc19e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7836","original_object":"UniProtKB:Q13233"}
{"id":"42cd51d0-ecd3-4dec-9cd2-dd8463232cfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48390","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:ba0b99b0-7cd1-4776-9c44-eafeb7632f43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3308","original_object":"UniProtKB:P41180"}
{"id":"9b87fd25-cd83-4ee4-ae97-c195092189c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993649","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:17e0e854-1049-4434-9c09-919b88f9b845","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12515","original_object":"UniProtKB:P21730"}
{"id":"c10f87f0-016c-4cdf-82ed-cf7b1e01a4de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827368","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:68708010-e7c7-4b25-a406-5a66d39c43e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8546","original_object":"UniProtKB:P43116"}
{"id":"f4bff4e6-09c9-4bb8-ac4a-1b453622cfe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:773a95f0-606b-4578-96a6-7cb614a83197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:P36888"}
{"id":"75558817-c741-40cc-aafa-ca59cec7e0a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134726","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:c2bb20e7-f66c-4c0e-9227-3ed9f65a9e54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5608","original_object":"UniProtKB:P29274"}
{"id":"6cc096e4-5168-4974-8120-81ed9c7ef938","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101882820","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:a98340a0-b880-49d7-a51e-6a76eb20b643","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13945","original_object":"UniProtKB:Q9GZQ6"}
{"id":"2da91ae6-b02a-4708-98bf-7865e180dc3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46173038","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:6c4fd40c-e76a-4669-85c3-d70a05c9450d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13266","original_object":"UniProtKB:P36894"}
{"id":"68eb7c68-3a34-4238-ba9c-f45573dcb6c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15650","predicate":"biolink:affects","object":"NCBIGene:239283","sources":[{"id":"urn:uuid:b50991de-0513-47b4-a2b3-2e0edc842a5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5863","original_object":"UniProtKB:Q6IYF8"}
{"id":"9e7b3a1e-0b24-4b51-b5da-a6c4854580a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4630","predicate":"biolink:affects","object":"NCBIGene:1543","sources":[{"id":"urn:uuid:301a94ed-f34a-4b19-b783-e4471c3c1b37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13861","original_object":"UniProtKB:P04798"}
{"id":"bae0f186-e835-406c-a386-4fd3e6d2c215","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3360","predicate":"biolink:affects","object":"NCBIGene:20264","sources":[{"id":"urn:uuid:7664b300-cd7a-457b-a396-74482976ff27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:740","original_object":"UniProtKB:Q6QIY3"}
{"id":"86ce5cf0-2f28-448f-a339-931f560c42bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101110542","predicate":"biolink:affects","object":"NCBIGene:83567","sources":[{"id":"urn:uuid:19659f25-5343-4442-85da-f08aaac6e7d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1293","original_object":"UniProtKB:P97639"}
{"id":"460ccf38-c331-4343-a9f5-d5efee0893c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7C00L34NB9","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:7fdbdc79-dc2c-47fd-9c85-70153ccdbc77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11137","original_object":"UniProtKB:Q07869"}
{"id":"21ee7631-bd7a-447e-aed6-3380c473c586","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118884610","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:3392fe10-900c-475a-a3df-9e791aa58121","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9891","original_object":"UniProtKB:Q92769"}
{"id":"1d191795-0a79-47b5-87b5-205c16521185","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:e2a5f8df-4262-4b6d-91fd-2d27239817c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P28476"}
{"id":"ac1b9919-d056-48f8-8f28-75f52406b747","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6522","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:c483df23-a310-4b4c-98fb-14db52b36900","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6522","original_object":"UniProtKB:Q8TDU9"}
{"id":"26783f60-1f32-4290-8e43-6bec9917df97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2086","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:05727f3d-a966-449b-8e92-b7ac05263b1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:145","original_object":"UniProtKB:P28566"}
{"id":"b153f7c1-05ce-4398-a6b2-8f9dd31dad93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:2a3391b7-535c-4908-a367-ecc74b7cacea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:Q14831"}
{"id":"ecdaad52-a9bc-4153-84cf-b2aadacd41b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755199","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:6c7a5839-275b-4149-80ed-9ddc55491bb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6237","original_object":"UniProtKB:Q14833"}
{"id":"be86c533-985e-4594-83b1-2b9f862906dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115335","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:38cfe857-0550-40f2-bc6b-ab193221d7bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1671","original_object":"UniProtKB:P35372"}
{"id":"2fb8853d-1c7d-4148-aed2-958c339acd98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5328804","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:f2d84345-0f3b-4a62-985e-064b32b5b4a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5913","original_object":"UniProtKB:P00533"}
{"id":"1264cc7f-9bbb-4327-8f62-7889d5bc3f8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86304165","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:97031c00-8130-41b4-aeec-b1388cceba4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13494","original_object":"UniProtKB:P21802"}
{"id":"8ee02875-2011-476d-81b5-7fccad37856f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92728","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:a4987afe-c213-42bb-91c4-c2397cdf628f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1433","original_object":"UniProtKB:P31424"}
{"id":"2c02b3f7-56d5-46b9-b0e5-a2a2ed75673b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231232","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:8388b684-53f3-4dc5-8352-141405a72c77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3529","original_object":"UniProtKB:Q16581"}
{"id":"44845c84-c17b-4635-83dc-c9affe998653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44243146","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:73652ff4-c1cc-41f5-a71d-e122eca056b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8758","original_object":"UniProtKB:Q9Y233"}
{"id":"8b5f886d-1bbb-45da-835b-8b9194bbc88e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165033693","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:0da38324-9b0a-4657-9331-5b3d48b2774d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5853","original_object":"UniProtKB:P43119"}
{"id":"877b0ed5-12a0-4aac-925d-eab3d877c670","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47344","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:c278c72f-0459-4392-9d5b-0e286adae290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5680","original_object":"UniProtKB:P24941"}
{"id":"085e5292-0b4e-4843-bd3f-31993b86deb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030520","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:b37895bf-a97f-494b-91b5-d0e31aee06b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10428","original_object":"UniProtKB:P51451"}
{"id":"306a0b6f-e6ac-4529-af2f-75b25ed5f964","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:40414359-e59e-47da-b125-3f1ef84da470","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P08172"}
{"id":"4e93ece5-a7e3-4637-a5e8-9a7ce28760c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230819","predicate":"biolink:affects","object":"NCBIGene:6505","sources":[{"id":"urn:uuid:6a51ebeb-cecb-4aa4-bb52-f5e38fc538bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4631","original_object":"UniProtKB:P43005"}
{"id":"8334b5e4-730b-456c-8946-5cd4f0aff36e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4495","predicate":"biolink:affects","object":"NCBIGene:16514","sources":[{"id":"urn:uuid:ef20743c-799d-4f8e-b8ee-984eb847303e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2409","original_object":"UniProtKB:Q61743"}
{"id":"a20ac62d-b220-4f27-a6be-aea088538959","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58298316","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:1af92215-2149-42c6-8ba5-75881059c12d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8914","original_object":"UniProtKB:P35916"}
{"id":"34d05234-8883-4c8b-a47f-21441c920b49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZC6062V1O9","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:d270e680-955d-48d0-8d3e-88dff239b699","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2640","original_object":"UniProtKB:P10276"}
{"id":"bc5d3516-e185-4c27-a9ec-55c638ef43aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7569","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:8182f049-f3eb-4f2f-b5f5-37ed20b92cba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7569","original_object":"UniProtKB:P04775"}
{"id":"64598cdc-fe6c-499e-8043-057a2f2f5f15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:691037","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:5cf9e449-1541-406e-a6eb-435f0f6664a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7067","original_object":"UniProtKB:P04150"}
{"id":"c994a1e1-791b-4b14-960b-b1b9e1330132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10127","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:375272ee-b245-4eef-8fb8-ea2601cd8322","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7047","original_object":"UniProtKB:O43570"}
{"id":"f07ee7eb-8d2e-48c0-8c8c-32b78872cc17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115007","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:f9b18c6e-3d67-486d-a683-05a1bfc8b19d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:955","original_object":"UniProtKB:P14416"}
{"id":"5afba2cd-116f-478a-8cbf-420aa54e8877","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311230","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:0892c8a5-db2e-4d71-b5f1-3489caac1e16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1933","original_object":"UniProtKB:P32240"}
{"id":"1243b835-2a8c-4842-97ca-f65733e1f297","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232556","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:c076dece-770d-491c-a292-6e6987da1013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9039","original_object":"UniProtKB:P22607"}
{"id":"14443d17-0548-481d-b1ad-c11d76a6263a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3TY57MQ4OA","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:38669905-b703-41b8-963b-67d7bbcc132a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2202","original_object":"UniProtKB:P30518"}
{"id":"5a424d08-8f78-4879-a727-6700b05a1ec3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:039f45e7-5a25-4ba5-b13c-a81b54164dec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P30543"}
{"id":"385f0227-2ef8-4b71-abf9-ffd2a4e2e6e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:7af5eba5-d13e-4c96-bbeb-33dbd9ade1b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:P10276"}
{"id":"25aa8fdb-f92a-44d6-a8e1-9d4803ae9163","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28973","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:705ed35f-01be-44a6-8a17-45c3a292bcdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:347","original_object":"UniProtKB:P11229"}
{"id":"f0c00091-48c0-40f2-81a0-9405aee24d96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:103828029","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:6f3245e6-214d-41f2-9a18-9fd35c9d7630","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10667","original_object":"UniProtKB:P48039"}
{"id":"923094e7-b524-4412-b637-f27381a256a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117123","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:99713029-13e3-4a46-b580-5e5113b7439d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4513","original_object":"UniProtKB:Q99808"}
{"id":"152d0e9d-aa5e-4046-b04f-6cba0901bc68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53323310","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:79b26413-58e4-4b93-b3bb-726f113dded7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4636","original_object":"UniProtKB:P23975"}
{"id":"81e2cbed-a84d-4f08-bb36-60f843389ae5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232603","predicate":"biolink:affects","object":"NCBIGene:5610","sources":[{"id":"urn:uuid:1eb44cd5-cd67-4ed9-92c1-e2e0577c5922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6026","original_object":"UniProtKB:P19525"}
{"id":"56b547d7-eb5c-4a43-bbd8-47a0170a41fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53340664","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:f2402521-baae-46a0-96cb-0e3c41a11ac7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8074","original_object":"UniProtKB:O43318"}
{"id":"8b16d6f7-4e45-4de9-a76e-33fc81cc047d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:612367d8-ce3c-455d-9e22-e1dfda4f8a1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q9UQL6"}
{"id":"c6015ec9-c8ec-4ad0-abcf-e0b8df1dafe6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:eea17172-ed2e-489c-8988-34673808e1c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P48736"}
{"id":"c0945af7-2d25-4a6c-8d33-e2d5805262ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OGN7X90BT8","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:bc6d402f-7866-4964-a118-6672133e69bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9772","original_object":"UniProtKB:P21554"}
{"id":"ec658785-ced8-4d22-a266-bde7c54b4c98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:314","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:b4776ef9-bacd-43da-81dc-e9a6d793d09a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:314","original_object":"UniProtKB:P08173"}
{"id":"a3989ee6-9266-4e75-b946-aa62ad0cbfeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60150890","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:931bb759-7176-4089-a67a-1c9815ecab76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12580","original_object":"UniProtKB:P08588"}
{"id":"7dbd2e0f-1e6f-43b5-ab8b-87ddfd63e116","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154025209","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:eb2bd1f0-3255-4602-abb1-5e3a4210ff13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11192","original_object":"UniProtKB:P07333"}
{"id":"3d310f80-cdc0-4b12-8b95-aae4ec58f26a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:200HA2LIMK","predicate":"biolink:affects","object":"NCBIGene:4294","sources":[{"id":"urn:uuid:4d6c2f19-63ed-4503-90d3-eef7de7d7025","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8173","original_object":"UniProtKB:Q02779"}
{"id":"82ee12da-46f3-4d6b-bfef-24fb33b3dc5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50902958","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:5e8eef73-9ae2-41cb-a2ea-aa1bad157f02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6262","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"2674daf3-9e26-4a54-bd1f-3a32d22fd455","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3964","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:0b902a56-4045-4b99-bf76-8106eb818ec2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3964","original_object":"UniProtKB:P02708"}
{"id":"bcf02605-7470-4f5c-8318-3e212ae5ee2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:c9c34ccb-4dc2-4e38-b12d-9f8a091bb85f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P34903"}
{"id":"52ddedd2-6564-4242-b295-b69caea75609","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5759","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:3ed0d404-b0c5-4e78-bc3b-827f7f988c11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11610","original_object":"UniProtKB:P09917"}
{"id":"51c6019e-0241-47d8-ac96-da4d2d15e4ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:5b7d3e5f-9cd9-48d6-83fe-3e72d8139d14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:Q16288"}
{"id":"4a8794e7-feb6-478b-8b58-a079b01ac5ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817479","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:6fdedd31-44ad-4bd9-928a-b606bf6d4861","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6083","original_object":"UniProtKB:O08726"}
{"id":"03667948-f4bd-4145-85cd-c0802319ae5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93519","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:0e85b82f-229d-4fa3-a82a-af05e318da58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:187","original_object":"UniProtKB:P14842"}
{"id":"9106dea8-3aa1-47a5-a9a8-42eb95688d44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232977","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:4327a679-fe69-47b3-8689-533f01de961e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10671","original_object":"UniProtKB:P09874"}
{"id":"6d6fc71c-07ba-4104-a6c9-c63e6962b55d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:714a14e5-4980-437e-9f3c-21dc5cf2b50d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:P15390"}
{"id":"7210c6b5-80c8-4605-8748-d6f2aa0ce2b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4C4P7L0W63","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:0f8d766d-3148-443e-8d77-de26cd3bf308","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1420","original_object":"UniProtKB:P41594"}
{"id":"28cc0cea-7412-41b5-94e4-c72fcfeff4cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:25689","sources":[{"id":"urn:uuid:3e65086a-2d26-4545-8a42-656173bf268f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P35364"}
{"id":"cc62b897-afc7-4efc-9b5d-1f63cfdc92d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9137","predicate":"biolink:affects","object":"NCBIGene:1555","sources":[{"id":"urn:uuid:4f583596-e7f2-4f28-a35a-e882b0d74831","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2586","original_object":"UniProtKB:P20813"}
{"id":"dad381b4-158c-464a-99bf-220ebc2900a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13815","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:193a5d84-55e1-47c1-a876-bb77128e93d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13815","original_object":"UniProtKB:Q03431"}
{"id":"1f4dd719-fb4b-4e4f-9ea9-d2e2c37fa3ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287532","predicate":"biolink:affects","object":"NCBIGene:1509","sources":[{"id":"urn:uuid:9ee98ef8-3175-4f03-8cbd-fe6a984fac2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11713","original_object":"UniProtKB:P07339"}
{"id":"9be46d0f-8e66-4999-901f-ed12030a38a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132157920","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:518814eb-aa4c-4170-a2a3-3c9d47ee6107","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11164","original_object":"UniProtKB:Q02127"}
{"id":"0fbd2f29-13ad-49dc-8d68-e1ba0495c6e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38937","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:badbe50d-a1ff-4956-8a53-04a697562359","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5927","original_object":"UniProtKB:P24941"}
{"id":"37b2270a-1f71-47d6-85e3-d315c925f53c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0N48AL0PRA","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:ceca7edd-a1f7-44df-9946-69a67b012ebd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6502","original_object":"UniProtKB:P08473"}
{"id":"90b8bd90-abc9-41f2-896d-6c4f2e799f75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9952446","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:72cd151c-5f9e-4a23-80b2-177cf9178662","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4251","original_object":"UniProtKB:P48058"}
{"id":"88cd8f16-2530-428c-a1e7-d13f74faa055","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118308154","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:5ae70c9f-1fdc-4f8b-8a80-084eb319b4a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13165","original_object":"UniProtKB:O43613"}
{"id":"9ea5ddc2-bd89-4701-a1ea-df7b698105c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:825e2088-830a-462f-9eba-c94684cc8a1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:P31749"}
{"id":"fc6780d0-6657-453b-a9a4-4bc2b52fd24e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9860294","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:cebb28af-2167-421d-9d49-6e3e154c762c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5613","original_object":"UniProtKB:P0DMS8"}
{"id":"4096b289-76e0-4293-ba9a-b87ed7931194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133818","predicate":"biolink:affects","object":"NCBIGene:23235","sources":[{"id":"urn:uuid:ac9d79dc-738d-4fac-b5e0-2c42ad7977e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8049","original_object":"UniProtKB:Q9H0K1"}
{"id":"c149d365-0065-4035-b070-53951e0c8f3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1389577","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:627530b3-60fd-4fa2-b3ec-a75a179bcef2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8728","original_object":"UniProtKB:P49798"}
{"id":"fdd412f4-bf36-49d5-8a4d-de2e9df4d951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918468","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:98dc07f2-6e69-4c96-8d69-2afa9139446b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:579","original_object":"UniProtKB:P21730"}
{"id":"8b99beac-088a-4325-9861-815b2ef97744","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:15JL80DG6H","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:bfbe8e4e-b137-4a0f-bf6f-78bf3fc2cbb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10658","original_object":"UniProtKB:P04049"}
{"id":"cb7cccca-bb2d-4584-a731-099ff82f5f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155818902","predicate":"biolink:affects","object":"NCBIGene:1514","sources":[{"id":"urn:uuid:58affc51-92e8-4ac9-902a-a7874ab3227b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11701","original_object":"UniProtKB:P07711"}
{"id":"f20665aa-c728-4cca-ab9f-76d04332308b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:62166","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:a4ccab01-3263-4c61-a451-4eb8a3876e7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9173","original_object":"UniProtKB:P00519"}
{"id":"c26a5a92-b0e6-41e4-8444-ba9e3b194991","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M964LB1114","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:79e789ba-dff8-4211-acdb-24708850bcad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12705","original_object":"UniProtKB:P33981"}
{"id":"ce78b573-dcf2-490a-9f8e-409960c54b51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9949","predicate":"biolink:affects","object":"NCBIGene:951","sources":[{"id":"urn:uuid:4c02ab58-60de-4230-8e10-28bc9b0e0248","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9949","original_object":"UniProtKB:P11049"}
{"id":"be13b2b7-551c-4e46-80f3-2487b2eacde0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95071","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:ecca90e4-3c4b-4f73-876f-ea7432a98682","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8365","original_object":"UniProtKB:Q9UQL6"}
{"id":"9018b5e4-b8a7-42e4-9780-d65b7433d771","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166642424","predicate":"biolink:affects","object":"NCBIGene:11184","sources":[{"id":"urn:uuid:328e69c8-bd79-4120-be21-a514da7b5ff5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12336","original_object":"UniProtKB:Q92918"}
{"id":"37f64cbf-7780-46ae-adbf-96484fb4fc22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:31a987b5-a180-4858-a8b7-dd6837b42168","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:Q02763"}
{"id":"6787a3e7-e598-4729-85e5-c331b0089754","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7CDW97HUEX","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:bf0f1e44-f178-42e9-9170-a238e2079e2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12283","original_object":"UniProtKB:P30968"}
{"id":"20c9838d-9606-4a35-85e3-caeaebccd608","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16796","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:060845bf-4e7e-41df-bb6a-fec1d5d74cee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:224","original_object":"UniProtKB:P48039"}
{"id":"a9d4c5da-7879-40bf-9c18-376e9cedc5ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2719","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:52007ed5-ab5c-4b3f-a625-164cfd1cb0e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2504","original_object":"UniProtKB:P30556"}
{"id":"c6242b39-a37f-4205-89f6-9b874a201741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5273315","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:6a9a41ca-61c0-4d79-9473-386dbfb1868b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:847","original_object":"UniProtKB:P61073"}
{"id":"a9a6a96d-d72f-4417-926a-cd6667d1ddc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182436","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:30d3a601-be97-4ff3-b21a-77f68b166f6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7495","original_object":"UniProtKB:Q92769"}
{"id":"5b5256f7-aeb3-41c4-abee-ca4c744f8c11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O4BT6C02M2","predicate":"biolink:affects","object":"NCBIGene:5690","sources":[{"id":"urn:uuid:c4633719-804d-4ce1-ba3b-61e78a1b45c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10409","original_object":"UniProtKB:P49721"}
{"id":"ecda8da7-d08e-4fab-8e74-45b8d42c1590","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2026","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:a2d3a8f0-3544-49ae-b574-ac80237720ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2026","original_object":"UniProtKB:P30874"}
{"id":"72201123-e03a-42ff-8c0b-bd2bf3899aec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:785f12e7-5a50-4e82-a677-0fef1773fcfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P23979"}
{"id":"2f042bc2-b675-4c0c-aa70-526f16d28c39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4650","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:9cf682cf-985a-4f85-b16f-5841bce696d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1617","original_object":"UniProtKB:P42866"}
{"id":"2b1cc796-f2e6-40c6-9a3e-2421914dd54c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSZ0E9DGOJ","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:639a9b3d-f7ef-4b5b-9450-cb1becd8b871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4146","original_object":"UniProtKB:P14867"}
{"id":"d779f1df-fb1e-4d6c-84eb-be197ef726aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4015","predicate":"biolink:affects","object":"NCBIGene:114229","sources":[{"id":"urn:uuid:36ea8d32-8b5a-4c88-8091-22966aaa513a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4015","original_object":"UniProtKB:Q91V45"}
{"id":"18bf7ea4-80f9-48cc-b1d8-06c493b62fcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8YYY3F3G47","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:eb11808e-10e4-4719-ab80-20d33d617221","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3491","original_object":"UniProtKB:P47871"}
{"id":"e49c2223-35e8-47be-b707-911ca932559c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCL936W835","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:5f6d5e20-e5dc-4deb-a1f1-da5576b7c3cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7743","original_object":"UniProtKB:P42345"}
{"id":"127e6b18-451a-4f02-9c5b-5f6b1d3cf163","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66524380","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:ca1ad837-c85b-47ef-aff8-bb6aaa04f049","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5695","original_object":"UniProtKB:P10721"}
{"id":"2d59a09e-94d1-4e71-9c71-247e95c3a3c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6105","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:7bfec969-1529-4f55-8b87-07a509446bbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6105","original_object":"UniProtKB:P47211"}
{"id":"3277c0bf-cdb1-4048-b52e-5f433dcb90bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31448","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:c152757d-b7d0-4ce5-a5fb-f02af5bbb334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4167","original_object":"UniProtKB:P42263"}
{"id":"d6aea1c3-da93-4803-a10d-1c43ab2f9db7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10656","predicate":"biolink:affects","object":"NCBIGene:115650","sources":[{"id":"urn:uuid:0c853eed-b6ca-40e4-af21-1967ccc02f2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10656","original_object":"UniProtKB:Q96RJ3"}
{"id":"582a412c-5abb-4d96-99a2-e7e6453183d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153640958","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:8fc8518c-9d1f-4b27-b7db-dcc8c21d76e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6230","original_object":"UniProtKB:Q14833"}
{"id":"ec9cbb2a-3eb0-4ed8-bb14-b9d0cd95ff03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3870","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:beb4815d-37a5-49e5-8c9a-382071f351df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3870","original_object":"UniProtKB:P30559"}
{"id":"1e98b994-d48b-4ac4-b8c4-dbe33777f70e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177460","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:a3d761b0-84e1-4207-9994-df11b3f97a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6281","original_object":"UniProtKB:O75762"}
{"id":"dc04a28d-d83d-4561-88a2-d7b684f0f97a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:33216","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:d63a9d62-aecc-4eae-a69e-e458472d7d95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7865","original_object":"UniProtKB:P10275"}
{"id":"47185e7a-cc77-454f-b37b-d6b5bc433d62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4582651","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:2135eaf2-ab6c-4e53-ba29-b6ffeb4e8007","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10033","original_object":"UniProtKB:P07949"}
{"id":"4cb937a7-df3f-48f5-b1e1-d2b63f023aab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:360","sources":[{"id":"urn:uuid:535b7028-590c-48b6-94fc-92107b0fceef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:Q92482"}
{"id":"5cba9355-4c2e-4d67-9915-b382b73882ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2026","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:c57e419a-55ac-4ac5-9634-a1a589b5fb43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2026","original_object":"UniProtKB:P30872"}
{"id":"e5aee477-8f3e-4987-a35f-85310d86b1f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2216","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:a4ff69e1-dab1-4748-bf8d-b1135afc93fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2216","original_object":"UniProtKB:P30518"}
{"id":"4ceed780-7690-47d8-9ee6-69831f96b016","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18388","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:bd043e37-9723-4b02-b3cf-d082fd5f4777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4136","original_object":"UniProtKB:P13569"}
{"id":"8377dc74-1d60-4325-9965-ab174e00e61f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134709","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:4d239f56-3f3b-410e-b7a6-d44d1b8edcf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8924","original_object":"UniProtKB:P25021"}
{"id":"b52301a5-c2fc-42a0-bddc-f4017448c360","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1164","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:d38eebef-2dad-4955-a56b-0cab7ad2b131","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1164","original_object":"UniProtKB:P30968"}
{"id":"bfe524ce-e8a8-46a8-bac5-41e3bce9c38b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3AK2RKG763","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:58693ff0-f825-4594-a159-c4d53cea9072","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:497","original_object":"UniProtKB:P35348"}
{"id":"74486c74-f517-41b6-a6fc-5c77234b5c91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67900","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:e3c2756d-abfd-452a-b27e-dd8ed3e5ae37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1666","original_object":"UniProtKB:P41145"}
{"id":"a4c76843-1dc1-4954-9762-5dd28f69af9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MIA4WMP8QN","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:4f84e757-e4cb-4180-b538-b7c732fe9cf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12648","original_object":"UniProtKB:O43497"}
{"id":"7337ec14-3d4f-4c23-ac06-004ee50d022b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34461","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:f6a3115d-4c02-4e01-8a30-a4aeed85a9d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4321","original_object":"UniProtKB:Q16445"}
{"id":"d6d998b0-532c-4b58-b265-42e3c183efcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77961","predicate":"biolink:affects","object":"NCBIGene:27334","sources":[{"id":"urn:uuid:6ebabe22-3c50-4002-b77b-cb952d0fc52f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2916","original_object":"UniProtKB:O00398"}
{"id":"3b022f60-be7f-4a31-a825-2181279881a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66470","predicate":"biolink:affects","object":"NCBIGene:8529","sources":[{"id":"urn:uuid:58693522-7cd1-4d5d-82a7-b5648f8f15f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11372","original_object":"UniProtKB:P78329"}
{"id":"6ef0436f-e7df-4964-9dff-83ddf9a85713","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44580457","predicate":"biolink:affects","object":"NCBIGene:4320","sources":[{"id":"urn:uuid:233775a0-c621-4b19-a8b1-5acef2c34d1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8665","original_object":"UniProtKB:P24347"}
{"id":"ada10c7b-f82a-4e47-ac3f-d4ebe2d788ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71576693","predicate":"biolink:affects","object":"NCBIGene:660","sources":[{"id":"urn:uuid:6a7db49b-9c27-479a-8599-8d6fd07b1fca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9269","original_object":"UniProtKB:P51813"}
{"id":"71415502-5287-4829-a460-767369c1f629","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43755","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:d6f99226-8bea-4d43-a190-a9000805c1f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6360","original_object":"UniProtKB:P12821"}
{"id":"58383f15-6e09-42d4-b573-2d25e3df6431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9806459","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:e9ae2aa1-3fbe-4b0b-9caa-0903bca5109e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5769","original_object":"UniProtKB:P21452"}
{"id":"5dd4d8d9-73ed-4848-ba8e-4f8558b24f88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9384","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:1d715194-e8ee-4c91-8829-97df92cb7fd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9384","original_object":"UniProtKB:Q9P296"}
{"id":"8557126a-60b8-4943-b2d2-61fd3320efcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132937648","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:ed6b4dd6-de04-4e48-8c19-9abcac3b2394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10521","original_object":"UniProtKB:P21554"}
{"id":"ebc998f4-1df0-4304-bec4-562cf3819ab5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:f8e0713e-b8ff-4083-b8e4-7706d3e81d85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P17948"}
{"id":"71c39f99-4629-4640-b342-cec5a91c0099","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3770","sources":[{"id":"urn:uuid:36850412-fc13-4245-bb58-17b91278e17f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:Q9UNX9"}
{"id":"7162d6dc-5842-4526-8396-bd544fecc604","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YMS878LR7I","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:111429d5-54c2-4e11-83a9-5d544c8038d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1395","original_object":"UniProtKB:P31421"}
{"id":"c7004d04-b93b-40a2-9c99-bce012df091a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121513880","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:9bc7e7d6-35fa-48aa-846c-6172fbaa4db2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10304","original_object":"UniProtKB:Q9EPK8"}
{"id":"d0cf34bd-5502-4d1d-ac94-ed41ceb1586c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10223","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:407ef3cc-2e7f-42b4-bd4d-e13e1668fc9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10223","original_object":"UniProtKB:Q969F8"}
{"id":"e3822d44-f4f1-4166-8179-cc38d43a44bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114904","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:69345ccf-6cbc-4a23-a058-fb3f9f9843f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2196","original_object":"UniProtKB:P30518"}
{"id":"a634fa17-fe8f-4c46-a91f-37ba04185163","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:9d4cd6f5-b336-4ab5-82d6-bac2c6e2649b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P36888"}
{"id":"5955d7b6-0517-4208-a82c-70dc387bdb8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:7182d6ce-d214-42fa-bce8-65fe94e44266","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9HBA0"}
{"id":"2b6afae1-e21f-442f-ad85-aea09d30b44f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163889","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4d3fb2ad-eeec-436e-888a-a3db3c37ba22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:446","original_object":"UniProtKB:P0DMS8"}
{"id":"5e1e2924-ed0c-4e0e-84f8-3c1e21f00f65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438353","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:4a787ca4-a6d0-4409-90c7-f3966e3538d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1634","original_object":"UniProtKB:P41145"}
{"id":"54b3d284-7d8d-4afc-8b67-22ecf5463812","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488984","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:1a3e9f4c-5e7e-408b-99e0-47b873c63a87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8236","original_object":"UniProtKB:Q92793"}
{"id":"abb0778f-5784-480e-8a64-18b2cbcb90c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3XVL385Q0M","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:b20c2241-47ea-4bbe-b5c6-61737a05e0b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7913","original_object":"UniProtKB:P23458"}
{"id":"2881c91a-eab6-4aec-928d-68d15507cc7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:095f6067-4ea8-42c7-b325-fe85b63ee14b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P43117"}
{"id":"0b3c98b6-c950-4b53-a94e-6705ac1562fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:921","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:305b1b30-6281-4692-873f-b43caccd9337","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:921","original_object":"UniProtKB:P34998"}
{"id":"4471bfff-1ca9-4fab-8381-0ec0e9749802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:3aed9f8b-dfb5-4d5c-8868-e803c005f1d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:P31424"}
{"id":"e8403c31-25fa-4556-bbdc-46eb53227577","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34946","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:c4d130bf-a411-4c99-bc57-8c2f50d6c417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1739","original_object":"UniProtKB:Q9BPV8"}
{"id":"fb1877ea-4cf9-41a9-a056-5bb4fffffb31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1PV3S9WP3D","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:37e98509-2005-4445-9202-4bc24643900e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7419","original_object":"UniProtKB:P15121"}
{"id":"dfa05219-a8b2-43a2-8800-9cf90d72a114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:efed2032-7d71-44ac-9b2e-1cdb7a155293","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:P06493"}
{"id":"a8701e6e-dcd8-4f37-85fd-e2b8d7e7730d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2608149","predicate":"biolink:affects","object":"NCBIGene:24409","sources":[{"id":"urn:uuid:ba5e2e1d-6a87-4cf8-9387-fa55ae71fd32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11700","original_object":"UniProtKB:Q00959"}
{"id":"684d4837-67d1-4fb1-b619-7decdf5dc137","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156273389","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:b5b452ad-db46-4d61-9a8f-8f527ab9c8bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12313","original_object":"UniProtKB:P22607"}
{"id":"c4745a1e-95c7-442c-92b4-5ce0cc6cd446","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137977202","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:ee2a937f-8b8e-4bf1-a40d-8796bbba6e32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10665","original_object":"UniProtKB:P48039"}
{"id":"16bc663b-ff2a-4f87-bb7a-ccb27dac8802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YKQ241VJ92","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:6b810582-6e4c-4f32-a47b-90a396c17fdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5689","original_object":"UniProtKB:P10721"}
{"id":"7bddf7da-ed24-4bd0-8211-7745f55599dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:06P3KLK2J8","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:13c1b51a-e3de-49a4-88ae-0fa6111a37d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12758","original_object":"UniProtKB:P11836"}
{"id":"b3b4fa00-ad94-409f-919c-42a95121b807","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817484","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:0641b51a-3410-4da2-97b8-a2b2bba590c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6117","original_object":"UniProtKB:O88626"}
{"id":"0ec4890b-e61d-453c-b181-58f3bc07ff84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827366","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:a88cb476-35cd-40a4-bc64-b26b67549a35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8520","original_object":"UniProtKB:Q01959"}
{"id":"7388d2c8-3ae7-4381-a1ed-47a77c76890d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:378807","sources":[{"id":"urn:uuid:de7edfba-f36b-4f48-9c43-fc8cd629fdb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q7RTX7"}
{"id":"daaa50b7-6eb0-4b86-8891-1035e3c38e61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2614","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:dfe7439a-557c-42a6-90d5-7d7c49f5e150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2614","original_object":"UniProtKB:Q9UQD0"}
{"id":"3086e1cc-51ef-4bc6-875c-50146412af02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71478195","predicate":"biolink:affects","object":"NCBIGene:22259","sources":[{"id":"urn:uuid:f8a23228-c13d-4fc1-90ea-b91a10eee0cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8692","original_object":"UniProtKB:Q9Z0Y9"}
{"id":"0fb8f276-fab1-4a66-8f73-12639670f6a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64117","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:47ce9d93-5bbe-4804-bdff-fcc2769c8fe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:970","original_object":"UniProtKB:P19020"}
{"id":"c5ad94c0-774d-45d8-b243-9aa4cf9c2ef2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135411347","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:033643f5-0435-48dd-9847-4764791dbae0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3261","original_object":"UniProtKB:P11229"}
{"id":"d31c8095-85dd-40f9-8fba-2cef12e9d8fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:a8cf6726-015a-413f-a87e-c534bd824d5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P32305"}
{"id":"60504b9a-ffa4-4660-a468-6f6f409fe7a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13353","predicate":"biolink:affects","object":"NCBIGene:7486","sources":[{"id":"urn:uuid:442f9705-8aff-415a-a93a-8ad3a6d41db3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13353","original_object":"UniProtKB:Q14191"}
{"id":"92ea9f8b-5045-4f2c-ba63-9b6609c98550","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827350","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:9657c3b9-835a-43a0-a404-482ab5be4579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6199","original_object":"UniProtKB:P51582"}
{"id":"7cd54897-bcfc-4c54-9fd8-c07e2f0b3782","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"UniProtKB:P30940","sources":[{"id":"urn:uuid:be8c1298-1ca1-41cc-99e1-f1c9844bf53a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P30940"}
{"id":"5345d12b-31a3-434b-a037-97c1d13b2bcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184076","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f7fcecb9-23e2-472f-9b23-80fd2bd1fb16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:414","original_object":"UniProtKB:P30542"}
{"id":"f53a094f-cb61-42c8-bb12-2445573918fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:169866","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:477c570b-0e41-4a26-9549-c2f497f4a9db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2465","original_object":"UniProtKB:Q8R4D5"}
{"id":"39fb93a4-c7f1-46fb-a4e4-564292980a03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13398","predicate":"biolink:affects","object":"NCBIGene:54814","sources":[{"id":"urn:uuid:cab81f9e-38b0-492a-984d-6d3d0c521b6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13398","original_object":"UniProtKB:Q9NXS2"}
{"id":"96e8c394-a89f-4028-a508-5bf059b886a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6140","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:fd7f5f9d-807a-428e-b0e4-cddd5fff48b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6140","original_object":"UniProtKB:O43603"}
{"id":"a5763d5c-55fb-4d9a-87e7-0f8c536ef407","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:cb026366-63e7-40ef-889a-22ee9fff226e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P25100"}
{"id":"e383d971-050a-4cf1-8577-4324d6573af6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7444","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:0aa12e9d-636c-4232-a5bc-1ce92621a477","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:554","original_object":"UniProtKB:P13945"}
{"id":"9fa66415-f500-42af-ab1e-d6100f6e8544","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9934294","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:e7edcceb-db48-4e86-afb6-c0f1ec1c23ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2607","original_object":"UniProtKB:O95259"}
{"id":"d3a54a6a-81d2-4776-9cdb-e728365c38b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486504","predicate":"biolink:affects","object":"NCBIGene:5145","sources":[{"id":"urn:uuid:32c79de7-4b69-407f-a640-2db4dabb83c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8811","original_object":"UniProtKB:P16499"}
{"id":"3556dae6-49b7-43a4-a7e4-826fdb394e19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0DXG50I4WD","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:11154545-b184-42af-a89a-270b6d1ce9d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12721","original_object":"UniProtKB:P23443"}
{"id":"b17139f4-dcfb-4f50-b043-f115ba00de13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:13fc397e-6d4b-46fb-a875-b960a92b24b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"biphasic_allosteric_modulation","original_subject":"GTOPDB:566","original_object":"UniProtKB:P23979"}
{"id":"c9a53167-797a-493a-b4ce-0fae8ab95ec2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:958Y70F3HQ","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:49ac9f0e-698f-4ccf-b900-8a871273b51a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7824","original_object":"UniProtKB:P41143"}
{"id":"823a7614-1e98-4d36-a899-3d3413448ac2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:544DR70TN4","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:b5aeb018-2856-4e8a-8a0a-921b85dffc94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10178","original_object":"UniProtKB:P34972"}
{"id":"efebac79-781c-4642-8140-6ae59b056248","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DV3HD37UBK","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:400df0bf-f574-4572-9c70-781617e47db6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8075","original_object":"UniProtKB:P36897"}
{"id":"6f507335-c711-483c-a7bf-23e1a8ef9eeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232342","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:edd42440-47c0-4dea-9b6f-037cddd691f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10149","original_object":"UniProtKB:P00915"}
{"id":"2b485e52-9125-41cb-9ffd-3ca262ecd352","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125551","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:7e8296d4-515d-4607-83b1-9ffe4161748e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1439","original_object":"UniProtKB:Q14831"}
{"id":"95c5654e-3ddc-489c-b0ca-ce2e83e1a09f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16741348","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:27ad0dfc-4e81-4dd1-84d1-878b679ba21a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1766","original_object":"UniProtKB:Q9H244"}
{"id":"f65b943a-8b61-4b78-a13f-d88dd28d19fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10058919","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:5de2f2e6-dc60-4ac9-97cc-8383788ea9cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3419","original_object":"UniProtKB:P23385"}
{"id":"c29ff32d-ee1b-436b-bcb1-fe4cae325409","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104162","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:0a51f869-abf6-41d0-a462-1d96d80d45dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10104","original_object":"UniProtKB:P08173"}
{"id":"d0d0052e-c9ba-4572-9dab-08fd4c6ae1fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:f2237dc6-e792-4b26-889d-ad6db698a3a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P34969"}
{"id":"ca367627-024a-4c60-9455-96f3b72eb812","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OGN7X90BT8","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:cb2cd1a7-3415-4c46-bbb9-ae43c7900fdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9772","original_object":"UniProtKB:P34972"}
{"id":"fc485775-6063-4af9-a0f7-d64e6be1e196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7931","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:53823881-49c3-4267-89d4-fbb9483ead40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2791","original_object":"UniProtKB:P11473"}
{"id":"90a0cb9a-4c54-4df3-9bba-830a7ca51e11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71605047","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:939ada73-e4d2-41d9-a2c2-98e22de6dd89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8147","original_object":"UniProtKB:P00519"}
{"id":"ef60e59a-2862-4497-abed-de923bdd52ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132181","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:ed679400-8b31-4027-bc4b-d12d15310e49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1830","original_object":"UniProtKB:P25105"}
{"id":"67d21d2c-fe53-46cb-8a18-2ced7699aa97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:126559d3-6c89-4b4a-8aab-24add9a43749","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:90","original_object":"UniProtKB:O95180"}
{"id":"fd57f6b0-58a0-4b8e-8a4e-333147a3948c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:240dc23e-59b4-4162-a580-b1b8dc32f76b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:Q62928"}
{"id":"91f10f1c-2564-411c-b149-e927a4126f4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:b7475a32-beb7-41eb-98b2-7d627a7c946d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P30680"}
{"id":"d85a6831-5b47-41d5-9018-9510f2a078f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25169383","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:53faf816-8d41-4db8-bc34-5210851fbd1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8081","original_object":"UniProtKB:Q9NWZ3"}
{"id":"02edd8b1-67ba-4580-8d91-819e3e19ddb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9067","predicate":"biolink:affects","object":"NCBIGene:4883","sources":[{"id":"urn:uuid:7ab69a88-07b5-4f9f-b86b-8ece4ec0d50d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9067","original_object":"UniProtKB:P17342"}
{"id":"00596bc3-1cc8-4361-a350-8e8f0fa85d03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755238","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:ac20a598-79b3-4e9e-8041-b881a20ef61a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6730","original_object":"UniProtKB:P17764"}
{"id":"976a322d-57b5-4d53-a976-a1fce2a2a6c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:24474053-a7a4-4423-b2a6-e84c9a93bc5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"mixed_allosteric_modulation","original_subject":"GTOPDB:4366","original_object":"UniProtKB:P34903"}
{"id":"a7de1a83-a4ea-48f7-ae50-fd0913256395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118877392","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:7d4924b8-0d28-477a-a0cf-18d3f2802eb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11495","original_object":"UniProtKB:P21453"}
{"id":"a55ea451-c9ac-48ef-9229-4174af278fe4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25105713","predicate":"biolink:affects","object":"NCBIGene:5337","sources":[{"id":"urn:uuid:8079e105-6593-4237-985e-46a07abd8efc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8782","original_object":"UniProtKB:Q13393"}
{"id":"bc22dbd8-bc91-4bcd-aae1-acdbe68c5fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134480550","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:4009d56e-8c4f-4857-aa0a-ffcf1767aec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12377","original_object":"UniProtKB:Q16620"}
{"id":"285922fa-2feb-45aa-abde-437666d1516b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4206","predicate":"biolink:affects","object":"NCBIGene:63895","sources":[{"id":"urn:uuid:740818f3-9577-4eb5-ac4c-fa8e13b3b613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4206","original_object":"UniProtKB:Q9H5I5"}
{"id":"68613e0d-76ad-4a8a-bc19-f4dff1a7c748","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72707143","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:480991d6-50d8-4fcd-8202-eabe98f4544c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11695","original_object":"UniProtKB:O43613"}
{"id":"4ce8d35c-6262-457a-89e2-a8278fe523bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135038","predicate":"biolink:affects","object":"NCBIGene:340024","sources":[{"id":"urn:uuid:ffc51db8-1cdd-40af-90c5-54b427c7bf8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10256","original_object":"UniProtKB:Q695T7"}
{"id":"c84fce3b-270d-4ee8-ae44-641fc7e28555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53358422","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:9674b48e-df15-4e83-981e-f9eba21ce008","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10312","original_object":"UniProtKB:O95977"}
{"id":"365eb061-dd03-4d54-b08a-18c243120ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993664","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:3e6127c1-2baa-4d3f-8d90-cbb81b3a9d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12606","original_object":"UniProtKB:O43613"}
{"id":"098394bc-2462-4d9d-ac3a-5d144da4f765","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817484","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:46b033d0-4977-40fe-9e22-2c81d1cca7e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6117","original_object":"UniProtKB:P47211"}
{"id":"89a1f02f-8a8b-40db-9017-117e160b9d29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F2B10OFV7Y","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:d086a3b5-c985-44ca-b04c-0d525a6bf5cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10300","original_object":"UniProtKB:Q7Z2W7"}
{"id":"f2bf6584-ee4c-4b01-a9da-42b56213c340","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817420","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:9680061b-076d-4933-8380-df770e8ce934","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1538","original_object":"UniProtKB:P49146"}
{"id":"c04a4c81-3c6f-429a-b924-3df45a4fd0dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2034","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:e905a963-5377-4d08-9d91-49f48fdd75c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2034","original_object":"UniProtKB:P30875"}
{"id":"db1dd737-ae60-4b8e-82aa-a14d2e797647","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45293","predicate":"biolink:affects","object":"NCBIGene:60581","sources":[{"id":"urn:uuid:04f95a42-88b6-4291-b53d-62a05d78a31f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12243","original_object":"UniProtKB:P11497"}
{"id":"49775e1a-c1b0-4ffc-b161-48aa29fc53f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MW2AIJ8USP","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:7bbef89b-b82d-4a46-87da-acfc03c8f156","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8499","original_object":"UniProtKB:P25025"}
{"id":"cac40dbd-14e4-4622-9e9e-d38f02693aac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40751","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:961127cb-a01e-4192-8f0a-feb4c2c2a94c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4450","original_object":"UniProtKB:P25100"}
{"id":"6f992a7b-92f5-4f31-8a7b-2e06ad187f85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:edac30b6-1d04-44d3-bdbd-4bb032f34ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:532","original_object":"UniProtKB:P07550"}
{"id":"5223eba3-75b4-4c8e-8f6a-1414262e6e74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:acac3607-f4f9-4bfa-8fe1-217c454bab8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P23975"}
{"id":"d5fa3136-f2f6-4827-ad91-8d4234d648ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163410393","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:4a97eef3-7250-499d-9be4-106fe6e21570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12057","original_object":"UniProtKB:P39900"}
{"id":"0c44b1cc-b6c0-4777-b5d2-daa7103326e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3773","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:a44e8842-474c-4af7-b604-af6ef83303b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3773","original_object":"UniProtKB:Q16581"}
{"id":"0fe31dda-0dcf-4f2d-ad7f-048e8571da2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:da15c3e6-19d1-410d-b4f4-c5164a46a13f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:P42680"}
{"id":"7c68db6d-a354-43ba-93df-8c036a865151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DE4G8X55F5","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:70ad327d-8106-42a5-a66f-ed9e4f226f9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9194","original_object":"UniProtKB:P41143"}
{"id":"5cc77bda-fa62-4725-91f1-1f8af5652e45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44477445","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:1f3817c0-6376-4863-8bf5-9b9cf336c43d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8151","original_object":"UniProtKB:P53667"}
{"id":"0803c0ae-f3ec-4f22-b517-baf264d4a8eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:d3089b76-a70d-450e-aa8b-0b2a96995e6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P20309"}
{"id":"fdf9d8cd-89ee-465f-9f80-8530d9e2b916","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16197121","predicate":"biolink:affects","object":"NCBIGene:9986","sources":[{"id":"urn:uuid:60f68113-4b59-4dd3-b714-880920de769a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8579","original_object":"UniProtKB:Q9Y256"}
{"id":"a00a09f9-de4f-4984-953c-670bae96ebbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1451","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:d6d991fa-422a-4c03-b9da-396f7bd23534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1451","original_object":"UniProtKB:O43193"}
{"id":"0894a6e1-66ff-4d19-9947-49e15d1f0f57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900918","predicate":"biolink:affects","object":"NCBIGene:4140","sources":[{"id":"urn:uuid:26114888-af6f-4d4a-9391-f93b12fe204f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11896","original_object":"UniProtKB:P27448"}
{"id":"48acbd8f-f192-4929-8633-012889565cd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94119","predicate":"biolink:affects","object":"UniProtKB:P49356","sources":[{"id":"urn:uuid:864b7de6-c2c7-4d2d-ac3d-46290435d536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6531","original_object":"UniProtKB:P49356"}
{"id":"d8e0679f-c74c-4951-bd52-ae82958e96bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:6098","sources":[{"id":"urn:uuid:b116d089-4394-4d6b-b68c-bb8318e9fa2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:P08922"}
{"id":"511256b0-3974-4421-aef9-d2bd5c6496bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7T1PY32ZPH","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:d7295b18-c92b-41d7-8b21-d9c7664ea9e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12620","original_object":"UniProtKB:P49760"}
{"id":"cae05bea-4555-4f80-b974-a5c619a6e683","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82698","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:3e56398a-0e13-4c7c-8eef-82f651920565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2890","original_object":"UniProtKB:P56719"}
{"id":"9f512128-9e33-4ff4-8fed-c7fdd78bf6e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124138271","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:283418c6-36e8-4fdf-a920-6fd9b3a84c20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10116","original_object":"UniProtKB:P35346"}
{"id":"66d2ab31-167c-4bba-939b-18cbac28c71c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2582","predicate":"biolink:affects","object":"NCBIGene:16508","sources":[{"id":"urn:uuid:3d9315a4-1dff-4fd4-9edd-1614b9e3e53e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2582","original_object":"UniProtKB:Q9Z0V2"}
{"id":"7eca0f63-7d30-4e97-a3d7-26d8c746d8f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232516","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:4d43655c-3796-4187-876c-77fc11596715","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6465","original_object":"UniProtKB:Q9EPK8"}
{"id":"d23725ad-de28-4804-91d2-5ba8c04aab2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136188827","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:2b64b709-01a1-43b2-aeed-b68f81396566","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8211","original_object":"UniProtKB:Q08881"}
{"id":"61698ce2-fd60-489a-9db0-1fed069352e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2184","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:7ff9272a-db57-4596-9f52-1449d649dc15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2184","original_object":"UniProtKB:P30518"}
{"id":"6bcbff63-d13e-45b4-9927-a0e6b2524783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9917025","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:a6f6296e-0bf2-40b1-b579-266e8fb48015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2204","original_object":"UniProtKB:P30518"}
{"id":"2130220f-5b01-4f16-9574-5745d8b26b81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:2048","sources":[{"id":"urn:uuid:e11541db-eca3-4ff2-88b5-92ab874b7106","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:P29323"}
{"id":"7045fdf9-4343-4b4d-973b-b987a5a73ffa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M3H4D91AY5","predicate":"biolink:affects","object":"NCBIGene:5481","sources":[{"id":"urn:uuid:7922d8ee-9ac6-4fb7-b827-143499c4426e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11612","original_object":"UniProtKB:Q08752"}
{"id":"29956f98-5f6d-48d6-a0b7-da97d561fc2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801159","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:d9f063da-09e7-46aa-93bb-bd1fe76cb672","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9688","original_object":"UniProtKB:O43353"}
{"id":"e4a9da9c-7393-436e-9e7b-4f4d7f039221","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3907","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:86b1493f-cbfa-4ad4-8e7d-8ec8c694dca5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3907","original_object":"UniProtKB:Q9NSD7"}
{"id":"0fde2de7-de0c-4256-a56d-817b9776cc3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:252ab48e-2167-4148-a42c-cd2f656cdbd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P19020"}
{"id":"1449f130-8b29-4d60-a613-8968cf57f867","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3842","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:432a65af-9758-4383-b84c-1e4d3f5a0453","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3842","original_object":"UniProtKB:P32241"}
{"id":"577ac8f6-713d-42f6-8604-c2016b0b2d5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6960","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:406d8d1f-5b46-4326-a740-2818678f8615","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6571","original_object":"UniProtKB:P12821"}
{"id":"57947198-7e93-472e-9eb0-b653befda0c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754997","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:1cd24d87-1ba1-4987-8210-b954021a6e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:735","original_object":"UniProtKB:P34972"}
{"id":"25d52201-1972-4ccb-b38a-b8facc5f3dff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94506","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:9ee71fe5-da78-40a6-82b1-5e2a987f8536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5932","original_object":"UniProtKB:Q96GD4"}
{"id":"805f3df5-4686-4f6b-835a-6940ae9b4b30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1513","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:3e8a9631-e31d-4314-b757-17985a6290a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1513","original_object":"UniProtKB:Q63634"}
{"id":"d3422f83-3f2b-499b-8353-bacaa219d739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:51bdb0d9-6f58-4c88-9f18-b8005dc66460","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2330","original_object":"UniProtKB:O15554"}
{"id":"286c1eb5-8670-4f71-aa0a-8bff7f0728f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156538665","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:9b6a12b6-4871-4875-9e61-23f6f3145c5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11948","original_object":"UniProtKB:P00533"}
{"id":"1fe1082e-22a1-45fa-8446-11367a0637ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:e36f46c0-9f78-4903-a0bf-b2b3be4e2e1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P09619"}
{"id":"4b07cd18-a525-4381-a714-b08de99e826a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9985526","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:24dc3e39-4c08-41ca-b6f4-be3bfcc3ba75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:293","original_object":"UniProtKB:P08173"}
{"id":"6b9162db-c591-4bee-ae57-ab14df4b70b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:3e7146bb-85d5-41ca-b940-bf6c7499d96e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P12931"}
{"id":"7c482a72-a211-4e0d-99cf-2bd8c47eab17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4672","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:c83d8013-c2a3-426c-b1a0-b34ddae7b0c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6809","original_object":"UniProtKB:P07437"}
{"id":"ca03e912-79c7-411b-93d9-3afc27529600","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6539196","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:330346d5-723d-4f99-a69d-ed51e0eef1f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8356","original_object":"UniProtKB:Q16769"}
{"id":"1bc141f4-d284-4f81-8ff9-4df12965c38d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3048","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:c2279aa2-8541-4c56-ab4e-4595d9cd79bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7601","original_object":"UniProtKB:P08482"}
{"id":"0b1d7959-9b4e-4954-9fae-574a4488d311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:1ebc7f50-f791-4fe5-a18e-6088af70e432","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P20309"}
{"id":"155baa50-31fa-43d6-bdc2-a29f641b7b1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35255","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:289f5580-3e87-42c4-ac23-05444d5cd081","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2503","original_object":"UniProtKB:O95069"}
{"id":"030e0cd5-f606-4293-9d8c-0161f0b7e382","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2272","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:e928caa6-63da-4d15-85d2-6534261eb926","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2272","original_object":"UniProtKB:P41586"}
{"id":"76703739-9a0b-45b6-85ab-9523fdac484b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368933","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:e246f7ef-f914-4284-a93e-53024523c142","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12171","original_object":"UniProtKB:P52333"}
{"id":"c46ee0b1-18e2-4f35-ab11-cb8d63977836","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166191898","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:bb27fe74-9bed-4132-b955-9f68fa112e32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12740","original_object":"UniProtKB:P0DTD8"}
{"id":"01ee4a34-aab9-463a-8e5d-c2399e96b11e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:12Z0SU967A","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:88af1183-f8be-46fe-8e6c-abcb1017c4de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1935","original_object":"UniProtKB:P43115"}
{"id":"b2d0de7f-aa88-4b5b-920a-48f92a42a9ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:4d945f86-bde2-4510-83c0-eb22e7711786","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2476","original_object":"UniProtKB:P54282"}
{"id":"5399712d-b247-449a-a296-862f0e7c7a97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48273","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:b1c59170-9162-434d-80d1-53581b66de51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:51","original_object":"UniProtKB:P28566"}
{"id":"3628ddb4-6c5f-4534-aeca-b7aee45d1721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50997674","predicate":"biolink:affects","object":"NCBIGene:435766","sources":[{"id":"urn:uuid:a3eb760a-9183-472c-b99e-e7d47557f2d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11806","original_object":"UniProtKB:Q5GIG6"}
{"id":"e71f4b3d-38f0-4a6c-949e-7f83c834d6dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192640","predicate":"biolink:affects","object":"NCBIGene:158584","sources":[{"id":"urn:uuid:8722b356-9942-43c8-aab4-b168e3b1bd03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5206","original_object":"UniProtKB:Q6GMR7"}
{"id":"56b894d5-aa15-47e7-9ad8-c8ee56fc0b95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139350422","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:5103ff60-467c-4aa6-8294-46fa242318be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12093","original_object":"UniProtKB:P08581"}
{"id":"567df3e3-e6fe-45de-a6fc-c226ae0aafc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:23416","sources":[{"id":"urn:uuid:9b76c438-e602-4461-957c-435a573c6286","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2356","original_object":"UniProtKB:Q9ULD8"}
{"id":"838e14cc-c7e3-4752-9033-51b61c7a390e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44477445","predicate":"biolink:affects","object":"NCBIGene:3985","sources":[{"id":"urn:uuid:fc1235dd-31f4-4158-b2f6-e5c01f551c76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8151","original_object":"UniProtKB:P53671"}
{"id":"964d79b4-a76c-4625-8825-f01d428d0430","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6858272","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:e3ae9b13-9b2d-4c72-830d-1171df83f4e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1612","original_object":"UniProtKB:P42866"}
{"id":"fcafd4d9-61f4-4a5f-bb58-7b0b606b4acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6219","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:ec4ddee8-f358-4a19-ac48-2afd966c4b9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6219","original_object":"UniProtKB:Q14416"}
{"id":"9e144cb2-4d20-4a56-8cf8-cfdf90e7befa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10204153","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:69dda2ac-edf8-434f-875d-661152ad2ebc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9136","original_object":"UniProtKB:O43614"}
{"id":"c95908b7-79e2-4055-858a-9b9038cabd0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3645","predicate":"biolink:affects","object":"NCBIGene:643","sources":[{"id":"urn:uuid:f5d83850-52e4-476a-a1c0-85c2f3c1d675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3645","original_object":"UniProtKB:P32302"}
{"id":"3d7745c7-6c6b-40ba-920b-f7a9c88e1d5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230531","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:1cf2fbdf-5b82-4242-9390-8bf8c613375f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8145","original_object":"UniProtKB:P04626"}
{"id":"e5629111-8073-434f-9230-3feb27ab023a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:658","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:9551d48c-5a38-413d-bc37-270dcb031c77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:658","original_object":"UniProtKB:P30411"}
{"id":"5b1413ed-2153-4cc4-9a61-aeaf80cb47a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13273","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:66dbacbb-f550-415b-b20f-4841ba938a66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13273","original_object":"UniProtKB:Q9HBX9"}
{"id":"b9fa7fc0-6dcc-4b7b-9c35-7dd904ae5ad2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127043060","predicate":"biolink:affects","object":"NCBIGene:2828","sources":[{"id":"urn:uuid:9c57fab2-471b-43c1-95b1-5c9bcaa9fa93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10207","original_object":"UniProtKB:P46093"}
{"id":"45fc9e92-9d74-4919-b83c-6e119d9f9058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13747","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:2880c5bf-faec-4d42-a16f-7be788e36bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13747","original_object":"UniProtKB:P23458"}
{"id":"27162ded-b214-4726-a2a1-af656256d9f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311338","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:c7e37dc6-1950-49b4-bf20-f426d58538c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1696","original_object":"UniProtKB:P41146"}
{"id":"8dd5b869-a49e-49f3-9567-d1cbb21e32bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422749","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:e5a2de78-9673-4a04-9b5f-f29c63393b49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12975","original_object":"UniProtKB:P49760"}
{"id":"f9022c88-f8b4-475f-9cf6-8abc73a8078f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91426","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:9660a732-2e58-4305-bc23-9a8f8918cac7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9693","original_object":"UniProtKB:P43405"}
{"id":"afa79c00-75e7-4f94-bd59-0dc47b2fddad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90872293","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:e476a2e6-3777-4486-acbe-1f24afa4e313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9312","original_object":"UniProtKB:Q92952"}
{"id":"6ec304fc-ca35-42ae-b7e9-4ec724d1e518","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184982","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:db445d53-ae95-4d11-995e-59c79e68325b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1239","original_object":"UniProtKB:Q9H3N8"}
{"id":"d8be0be2-ec8c-4b62-a588-6eea647043a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:4a0f3bb8-8919-4e2a-a804-ba6c9129274e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P08908"}
{"id":"ddb2ceb3-580e-4d4b-9231-ed615bb1559f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1489963","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:19bcc8fd-034a-444d-bf4d-64b0c3ccba96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6435","original_object":"UniProtKB:P41594"}
{"id":"3325618b-1044-4d3c-9d4f-d2c8d541fda9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:c6432046-eb1b-4634-a559-c31026700a94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q92508"}
{"id":"0dab2ae9-5bdb-4a71-84f8-b64a6534993b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71278111","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:5f1f272b-1da1-4599-af37-38fb3ff2dcc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12114","original_object":"UniProtKB:Q07343"}
{"id":"d2c64052-7e79-4cd7-9d06-325d41914a64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10140","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:eae4cbdf-2d04-4ec5-85f0-7d0db62b79f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10140","original_object":"UniProtKB:Q15116"}
{"id":"395ec995-65d1-40fe-9f39-47fbebfbc85a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2028","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:f16894d9-5c32-420d-b967-669f5562c52e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2028","original_object":"UniProtKB:P35346"}
{"id":"40423a43-ce63-498f-b414-e22a6268b869","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754990","predicate":"biolink:affects","object":"NCBIGene:15557","sources":[{"id":"urn:uuid:26282a21-a46f-4e88-b5b8-13c6b7a2f230","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:261","original_object":"UniProtKB:Q02284"}
{"id":"e994e23b-b884-460d-87ad-c4b722feade9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519431","predicate":"biolink:affects","object":"NCBIGene:2854","sources":[{"id":"urn:uuid:a1957b10-348c-41a9-8868-9dfd59cb676a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5555","original_object":"UniProtKB:O75388"}
{"id":"ec6d2fd1-7c91-4f9e-93bf-8820ec20fc84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817483","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:6516c067-383f-4d04-b689-5401a426dfea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6094","original_object":"UniProtKB:O43603"}
{"id":"d307b2ef-dd36-4136-8ee8-2333c4fdc977","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91426","predicate":"biolink:affects","object":"NCBIGene:1147","sources":[{"id":"urn:uuid:8bff4b7c-56c6-47bc-9b26-2d7ad4fa49d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9693","original_object":"UniProtKB:O15111"}
{"id":"a04ff9af-e3a4-49c8-b53b-cb38283b764c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:db403d8b-bfb2-4d35-9bab-c43635c1c01b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P14842"}
{"id":"600b9d0b-b48d-4a67-83fc-7b06ee0077a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:f57f1348-c7f4-450d-8328-edfc1f0261a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P36888"}
{"id":"2351a5e7-6af0-4ea1-80f6-8c287df5ccd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162524593","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:3a7f77c7-e6ae-4532-a46b-68539a108ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11946","original_object":"UniProtKB:Q9UGN5"}
{"id":"d057e2fa-be03-427d-ad03-1fb534811437","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121990","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:d8817f65-a427-4431-9818-ea6614c8b00b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1710","original_object":"UniProtKB:Q9BPV8"}
{"id":"3b96da8c-af2d-4912-b42e-65a56b621e87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:100978427","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:6c4586bc-ede7-4ed8-ae2f-b9d9d53a7403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:645","original_object":"UniProtKB:P97583"}
{"id":"c0a7971d-38d4-4137-92e9-a39e0f3a13f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123739","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f0aa1e61-96b3-4333-a632-393df7efbdb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:428","original_object":"UniProtKB:P29274"}
{"id":"12c8cb0b-74df-41e4-995d-bb8f66ddeb50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90545","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:9a3c323a-d96d-4c9a-a11f-b29c69fd3c0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7965","original_object":"UniProtKB:O00329"}
{"id":"56085652-de0d-4a58-8deb-c8ff732bbe9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90705","predicate":"biolink:affects","object":"NCBIGene:2580","sources":[{"id":"urn:uuid:a5549edf-68a0-48f2-8ae4-79431126c886","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5269","original_object":"UniProtKB:O14976"}
{"id":"53473111-5c94-4008-aed3-4d0b659faf4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121349608","predicate":"biolink:affects","object":"NCBIGene:124274","sources":[{"id":"urn:uuid:336d9948-7349-449b-bcaa-bb30210d9023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11685","original_object":"UniProtKB:Q6DWJ6"}
{"id":"e6d22b03-3b22-4a08-9ddc-e663f6ba1d49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QJ8RO3296G","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:d46c288d-9a2d-4950-a9c7-8e456ceba8fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11879","original_object":"UniProtKB:O60285"}
{"id":"26ec7282-55e8-4cad-8f57-c2c9955fd5b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L94KSX715K","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:c6f3c61f-be8f-417f-beab-b40583a9c840","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8260","original_object":"UniProtKB:P25101"}
{"id":"1c4649e8-dc5f-4ddd-bec4-a5cb288a8f2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167450","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:81338ccc-8f75-4dbc-9288-ae2ca7ac3b47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5786","original_object":"UniProtKB:Q8TDS4"}
{"id":"e2affd3f-2c19-4138-9afd-7a559671cc4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15355","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:c72448c9-ceda-41d7-88d9-437b5f103191","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:294","original_object":"UniProtKB:P08483"}
{"id":"48e468b1-e03a-46b1-875c-2ea64bfc3382","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U07H877HUF","predicate":"biolink:affects","object":"NCBIGene:16542","sources":[{"id":"urn:uuid:26a2c8bf-10be-41a5-8245-80e9061c7f76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6053","original_object":"UniProtKB:P35918"}
{"id":"076e30ef-28f2-46b5-b4c4-999654bad89b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76313567","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:a7d60051-6bfd-4224-ba8d-feb4468a239c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9481","original_object":"UniProtKB:Q99685"}
{"id":"84179d84-8629-4b15-b341-8cb2b4a9407c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:82c32ab3-be91-4661-a766-06690ade8a17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P28334"}
{"id":"dcecb666-5805-4dd1-a817-8ae93a6fe8e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QC4F7FKK7I","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:a20c073c-2005-487d-b8a6-43bc9fadc4a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8529","original_object":"UniProtKB:P30559"}
{"id":"05df1499-5026-44e6-a83a-1ed6bc45f9bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98DE7VN88D","predicate":"biolink:affects","object":"NCBIGene:2348","sources":[{"id":"urn:uuid:36aa52cf-4a3e-4f99-9663-49c9e457cb1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12250","original_object":"UniProtKB:P15328"}
{"id":"6688e4ba-8419-44eb-a824-5de7b99d7dd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EI4HZ6P03E","predicate":"biolink:affects","object":"NCBIGene:11096","sources":[{"id":"urn:uuid:f7d66402-9624-4e83-a37a-5a481b2360e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12778","original_object":"UniProtKB:Q9UNA0"}
{"id":"125971ff-0b29-4c96-abb6-6a143509de24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:6f5cf113-56bd-4c5d-a633-84cf8e3480a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:Q9H3N8"}
{"id":"936c3c8e-84df-4921-b7df-b69dccb62cc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71655266","predicate":"biolink:affects","object":"NCBIGene:327","sources":[{"id":"urn:uuid:d7eebc56-155a-4e40-a4cb-9c0bf3d6e258","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8563","original_object":"UniProtKB:P13798"}
{"id":"75fa547f-78d9-4d8b-b011-f14a525d57ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9833","predicate":"biolink:affects","object":"NCBIGene:2204","sources":[{"id":"urn:uuid:a1896e05-5af2-45f3-80ef-f381f68792ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9833","original_object":"UniProtKB:P24071"}
{"id":"a70b6980-7ab3-4872-becb-28902ddec717","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134182831","predicate":"biolink:affects","object":"NCBIGene:5781","sources":[{"id":"urn:uuid:3bda05b7-0e2d-44d2-a854-311e97ff3627","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12067","original_object":"UniProtKB:Q06124"}
{"id":"4331e219-ec70-4f68-883f-0db72dd37c14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:06H865SCMW","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:2907d5c8-6fbd-4b7f-8d78-12cfad663d0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10162","original_object":"UniProtKB:P48736"}
{"id":"d051c6e2-afe1-447d-82aa-39a59bebe07e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135747","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:3e84710e-7bdb-4c86-ba94-e4a2e36c6733","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:889","original_object":"UniProtKB:P32238"}
{"id":"3f687953-8e0f-4787-aef6-982a9e0b9c2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679531","predicate":"biolink:affects","object":"NCBIGene:7101","sources":[{"id":"urn:uuid:a718d15d-5e92-4c87-861a-2a3eca67cfd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11832","original_object":"UniProtKB:Q9Y466"}
{"id":"9f594edc-e2b5-46b1-aeda-549ea7c6ffd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44392752","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:d1ac13a3-c0af-4485-b190-97f74c0527fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2908","original_object":"UniProtKB:Q92633"}
{"id":"904dd5d4-777d-4069-930a-7e88b2ee4f95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:d037a9de-5251-4c5a-ae3c-b42291191efc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P31388"}
{"id":"5a1350cd-6f26-424b-a5e7-f7c62188ef5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85980","predicate":"biolink:affects","object":"NCBIGene:24613","sources":[{"id":"urn:uuid:f34f5a20-c909-4272-9f2e-53fd93c60178","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7691","original_object":"UniProtKB:P33533"}
{"id":"d4cb72e6-bcaf-427e-954a-cd74e315d968","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:8722","sources":[{"id":"urn:uuid:9b4763c3-4723-4730-a6be-9a3f3458d203","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:Q9UBX1"}
{"id":"e57d9abb-8cc4-4ee5-924a-0770e6c39094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2567","sources":[{"id":"urn:uuid:b3bf9272-c767-4e18-b54e-008370ccf522","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:Q99928"}
{"id":"5b1e6ca0-a8de-4c2d-92f9-80d5bdc2c312","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133823","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:7fc444f9-6650-4fdc-82c0-a2863715d66a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3592","original_object":"UniProtKB:O43603"}
{"id":"01ff4ead-dc21-42e5-9fca-287293f7d493","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4316","sources":[{"id":"urn:uuid:384dfe8d-4578-479c-b051-5678118baf3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P09237"}
{"id":"f38ddc67-2b87-493f-b753-0ef104e40a83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1480","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:981a35c1-c1aa-4d45-a3b1-57e00d01e815","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1480","original_object":"UniProtKB:Q9GZQ6"}
{"id":"a6da5d4b-0f67-4d57-afa7-53a0ccc06296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IC1B8751F6","predicate":"biolink:affects","object":"NCBIGene:1585","sources":[{"id":"urn:uuid:3aa02126-5a73-4ba8-abf9-8120aecb3f0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13884","original_object":"UniProtKB:P19099"}
{"id":"017da3ef-b5c4-4e8b-a6ed-977a64534183","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54752934","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:c3bcf382-3c4d-42c5-b6b1-14f607ba399e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11635","original_object":"UniProtKB:P0C6U8"}
{"id":"348eb084-3970-493f-896a-7809ae4da4a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2056","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:f1ac695d-f7b7-491d-a9c6-a3602b99581e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2056","original_object":"UniProtKB:P32745"}
{"id":"303f3e8b-943c-416d-b3f1-e0b2d3f99287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50985208","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:1f9b0784-3366-4bae-b5ff-97cdf51e3f2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13358","original_object":"UniProtKB:Q86X55"}
{"id":"02c3f7e8-edc0-4c1d-af19-426c8e5a443d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817479","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:27f0ae36-e7eb-4fff-a804-fe9d62285958","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6083","original_object":"UniProtKB:P47211"}
{"id":"d71de603-0be6-4d4a-bfc5-13f8d2d0efbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73389638","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:c091feff-a54d-483c-9387-57da7063b27c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9761","original_object":"UniProtKB:P42680"}
{"id":"657dfea9-1fe0-495b-b128-581e9d2236eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16207728","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:17684111-6dc3-4437-b18f-031bc3c687e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6275","original_object":"UniProtKB:P25090"}
{"id":"5c8cc545-86d0-4bb8-8ce8-fac8c2a13ce4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:86543","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:a4a730ae-780a-443a-b1b9-9044a73cdef9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5796","original_object":"UniProtKB:P49019"}
{"id":"8e477a70-58de-4d6f-9145-678e35a4a9d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S888WM4024","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:451eb7c5-829e-4fcb-b803-8f5bd06d04ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3191","original_object":"UniProtKB:O95749"}
{"id":"dcd2d603-f78f-4eea-a50e-8f9636384da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233593","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:34d29c2c-f30b-4ac9-a286-2d6e93593365","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9913","original_object":"UniProtKB:P09619"}
{"id":"b050fe16-8fdc-4662-8004-f5b31cce8b6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135169285","predicate":"biolink:affects","object":"NCBIGene:6768","sources":[{"id":"urn:uuid:bfbc71a2-ec52-400a-94b6-27479597bd0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11956","original_object":"UniProtKB:Q9Y5Y6"}
{"id":"14927355-6207-4db9-a717-5c75be62c623","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:3c7b7ac2-81b4-4573-995c-4753ccb7d1f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P14842"}
{"id":"c2d2cb24-0551-44b6-8310-6e6f93d8b058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233170","predicate":"biolink:affects","object":"NCBIGene:6095","sources":[{"id":"urn:uuid:4517ca24-aeb8-4c78-8ea9-3e249666f358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3432","original_object":"UniProtKB:P35398"}
{"id":"212ee313-6c24-4e94-a172-216205534adf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MAF34143WM","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:c429b3e1-6fa5-4942-ad59-a9688717e2aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8911","original_object":"UniProtKB:Q13464"}
{"id":"9150cb02-086b-4a96-9aa2-bc3e7ada2004","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I1YQT8HC89","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:d0f480a5-5cec-49b9-ad79-dfd8334e917e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12372","original_object":"UniProtKB:Q13546"}
{"id":"7c9d4b3e-f160-4aa6-a530-c0fb67dacf8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:12066684","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:17f0bcca-3b68-45d7-918c-75a4de09f928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3169","original_object":"UniProtKB:P14324"}
{"id":"5da497ee-d8bf-4f90-864a-67a7c98b635f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107660","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:34d740e8-e835-4f56-bc92-504dafcdc4ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2361","original_object":"UniProtKB:Q13224"}
{"id":"f3ffa329-c39f-47b5-8d33-44edd2a2f86d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92715","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:2fcab6a2-598a-405e-8fc1-c0d5e5c7b547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5994","original_object":"UniProtKB:P52333"}
{"id":"537485e6-1a2b-4fe4-b17d-88f020ab4fae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131169","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:8a6afcf7-62f9-4d24-9f89-0df3d01ee4bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7795","original_object":"UniProtKB:P42336"}
{"id":"f3f48804-ed4a-47e7-a8da-87191d87c010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:35C6UMO5SR","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:00e93bbc-5ad7-4c42-8ed5-4eaf6bfcdff7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:101","original_object":"UniProtKB:P50406"}
{"id":"1f0b8709-0f60-4d30-af44-92d6427c07e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:74760","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:293c1f20-c69e-44b5-8665-8a04734f2ac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1269","original_object":"UniProtKB:Q9H3N8"}
{"id":"f2372a51-8a43-4419-b3b5-ddb6bd26d9db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16662746","predicate":"biolink:affects","object":"NCBIGene:4751","sources":[{"id":"urn:uuid:c901a01a-780d-4d5f-a83c-81cc7df35228","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8149","original_object":"UniProtKB:P51955"}
{"id":"76195e7e-c715-44c7-9745-c545169a77d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LMX71OP17X","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:9d38a64e-4b34-4a8b-b680-e4b38887b3f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1907","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"0b6b0393-d65a-4592-bfca-08ba0731df40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16039","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:5f94c8d5-f2b4-419f-a413-ae24cae6d952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1743","original_object":"UniProtKB:O35811"}
{"id":"682667bc-c900-4f43-b34f-0380f5d65c67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2MK663C346","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:7db75981-548b-4a2a-937b-f9ee6a36516e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:672","original_object":"UniProtKB:P30411"}
{"id":"942de2e8-6843-4ead-b27a-725da34a32a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:c6e99806-02dd-4257-9153-6c9efd922b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q5XXA6"}
{"id":"4950fa6c-05e9-4b24-bbca-cfe8c0e55afc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9810112","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:d108cb36-54f5-4ebd-815b-62338d0839fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9651","original_object":"UniProtKB:P24530"}
{"id":"69fef6fa-f803-48b5-b8a6-f215c958d103","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221649","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:54c4fc78-14d7-40b7-88b1-50a865aac362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10280","original_object":"UniProtKB:O43614"}
{"id":"f97c6d71-88cc-42ed-a4d6-d5500bca0b8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93181","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:e39fc58d-cf8e-4f0b-a0b9-17534629301f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5048","original_object":"UniProtKB:P08069"}
{"id":"b759597e-a080-4c39-9308-1eab91845b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1795545","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:a9dad1d7-b618-43a2-b175-77e5769cef0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1414","original_object":"UniProtKB:Q14831"}
{"id":"d6e24ecd-47a7-4bfd-9210-838dce6bfd2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KG6VO684Z6","predicate":"biolink:affects","object":"NCBIGene:974","sources":[{"id":"urn:uuid:ee658085-6580-4f60-9739-9f9923a42402","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8404","original_object":"UniProtKB:P40259"}
{"id":"7a9149b6-786d-408a-8c14-2a43148e93b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25150704","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:581d22eb-5c57-4d54-be26-cdd88bc97b10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1202","original_object":"UniProtKB:P35367"}
{"id":"86a04fb5-1164-4264-8d9d-395b96c959ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:78I4VEX88N","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:5d4a7bd0-2b17-4671-a54f-5b39d453808e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7880","original_object":"UniProtKB:P04049"}
{"id":"a8744215-573f-4766-b183-6089aa261ec3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9951","predicate":"biolink:affects","object":"NCBIGene:951","sources":[{"id":"urn:uuid:6ab0f92f-799d-41f0-bc54-0a0d74d20373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9951","original_object":"UniProtKB:P11049"}
{"id":"b50d2f09-10ef-4ab6-bd1f-4f4e6e2ced7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189867","predicate":"biolink:affects","object":"NCBIGene:4921","sources":[{"id":"urn:uuid:abcde1d3-107f-45e2-a1b6-0dbf3c161e61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9354","original_object":"UniProtKB:Q16832"}
{"id":"03f0755c-f868-4bb2-8804-2da5a6d43ba5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114764","predicate":"biolink:affects","object":"NCBIGene:11622","sources":[{"id":"urn:uuid:afe607d8-9201-4065-b98c-3b1a86596c84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10046","original_object":"UniProtKB:P30561"}
{"id":"cc42fd87-4332-4802-944d-b4e49e8e5b50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2252724U5N","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:346baf57-faa6-4aeb-9551-41702c3586c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7647","original_object":"UniProtKB:P04626"}
{"id":"60ad6086-3e09-420c-af51-4a621e33e0e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817478","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:b711c06c-47e1-45a1-8d2c-62235665015e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5839","original_object":"UniProtKB:P21462"}
{"id":"46a755bb-f3d0-4771-8bba-a567306d4ec4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31899","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:cb266481-e3cb-42d0-9f68-9e7d2c3a584a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:962","original_object":"UniProtKB:P35462"}
{"id":"d85bd34a-4a96-414a-abef-37d9e1de2b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134717374","predicate":"biolink:affects","object":"NCBIGene:51548","sources":[{"id":"urn:uuid:7224a44e-e10b-4b76-af6f-0320b18ec092","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10123","original_object":"UniProtKB:Q8N6T7"}
{"id":"e4f617c1-68e4-487e-874d-5cb1c37759da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11527661","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:787cc5b6-4e3e-4c7d-897a-5ad3a53304e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9045","original_object":"UniProtKB:P41597"}
{"id":"daa70fdf-fd1b-411d-be85-e6d9e235aea6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:6c7ece95-2bf7-4b34-8345-8ab160c0ee10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:P48050"}
{"id":"7a3ad9d7-5a60-4ff7-8e64-c3d27b22d3cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3GBO34D1BE","predicate":"biolink:affects","object":"NCBIGene:5153","sources":[{"id":"urn:uuid:22a71ae3-3b43-4e1e-a8ea-1386596b892c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12003","original_object":"UniProtKB:Q01064"}
{"id":"111565f6-81bf-4231-a12e-1784af990bab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754995","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:f944c50f-bf7e-45e6-8e7f-453c942036be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:482","original_object":"UniProtKB:P25100"}
{"id":"3104649d-621f-42bb-8f40-d05f25ddb40d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2057H3EG0S","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:236ba0c7-06bb-4845-985d-e1940f3bb979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11537","original_object":"UniProtKB:P21731"}
{"id":"f91a21ee-3efe-437f-a690-73994a6d1308","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2060","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:34f82cfb-dede-4bfc-b434-b0fe4082ec03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2060","original_object":"UniProtKB:P35346"}
{"id":"752a9746-4eb4-489a-89cf-947d0c4af52c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32181","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:8563258b-1e87-439b-a023-17a866894f52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2648","original_object":"UniProtKB:P10826"}
{"id":"60f8b84c-849e-4e29-a832-b1f5fded0d0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:939111","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:b693b5a7-2c22-4588-8565-dc425c1aab4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8115","original_object":"UniProtKB:P49841"}
{"id":"e42f8a11-4c17-4300-af9d-4ca55c5e127b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11492393","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:2e8deee7-8086-44ac-a8c9-6eed9a1cc882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1263","original_object":"UniProtKB:Q9Y5N1"}
{"id":"5ffd98fe-1f3c-45e8-a8ca-26fe9cb536e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:209090","predicate":"biolink:affects","object":"NCBIGene:1509","sources":[{"id":"urn:uuid:f173fcb6-4fdd-4f8d-8765-1c8fcc09422d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8674","original_object":"UniProtKB:P07339"}
{"id":"9c3e3e86-a7f6-497b-bbcc-825cd3712f51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145365","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:7f5d3ca6-7f70-4816-88cf-c0ee412601bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7882","original_object":"UniProtKB:P07333"}
{"id":"3d9dcfb0-7a65-4a71-a4fd-a026b13b28d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:b8347003-1cd5-4595-9f55-de9ea3bd9e1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P30994"}
{"id":"2650f3aa-3c17-405d-8916-3c7f4a99aa5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:57551","sources":[{"id":"urn:uuid:c5a8be59-d0c1-486c-ba85-690b26a1fbb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q7L7X3"}
{"id":"c909ade1-4ec3-4d85-9059-195a8f11aabb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63620","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:5fe00519-b069-47ce-ab80-82b522398de7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6641","original_object":"UniProtKB:P27338"}
{"id":"9d7e5504-ac58-429a-8d69-204c90caa3e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801161","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:a490ed31-5b16-41c9-a3d3-65070c34c461","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9700","original_object":"UniProtKB:O43318"}
{"id":"5cdf7650-518a-4421-ba42-0a1d605c2d73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5ZHA5P4PFX","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:ff4fade1-df94-4e4f-9419-7950be32945b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11189","original_object":"UniProtKB:P11802"}
{"id":"8e3df759-d3e9-4390-a006-21ff8f206791","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9163","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:d0913ba5-e1f1-424f-90d6-c75aa8f86ac3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9163","original_object":"UniProtKB:P20594"}
{"id":"77d17411-d23b-4c7b-914a-447812f569c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z5MR2Y1IJJ","predicate":"biolink:affects","object":"NCBIGene:6523","sources":[{"id":"urn:uuid:12a7d572-3624-48ee-9ffd-67ed2b736c71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11905","original_object":"UniProtKB:P13866"}
{"id":"a550e6ab-c558-4973-a59b-843f53ac66e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801483","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:d16f8902-6164-4e0b-8e5a-93993a612f94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10547","original_object":"UniProtKB:P24941"}
{"id":"2fc2076b-7e22-455a-9b8d-3b3210dbe7e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28852","predicate":"biolink:affects","object":"NCBIGene:378807","sources":[{"id":"urn:uuid:14c63f67-f9e3-41a2-83d9-5f59edf228d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5412","original_object":"UniProtKB:Q7RTX7"}
{"id":"4e65ebbf-598d-4a35-a317-9c8063b02f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118936948","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:8c17c965-46a3-4df5-883a-6cfb8baf2c54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12167","original_object":"UniProtKB:P49137"}
{"id":"b821ec2d-00ec-4cd5-81c2-6a5628da0dc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6427","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:ad230959-cd67-4eb9-aa36-515dacd9299d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1175","original_object":"UniProtKB:P30968"}
{"id":"4175248e-ea72-48c5-afb0-3982437f3319","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53233899","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:bf4a38d5-fb7d-464b-88c3-919b34dfb4d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5830","original_object":"UniProtKB:P21462"}
{"id":"a14ac932-aeef-46f6-84b3-15a2fe7007c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817489","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:fe2986f7-26ed-4500-8041-67dfa04dbadd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6166","original_object":"UniProtKB:P52500"}
{"id":"a5474e67-deb1-498f-9d28-45480f4bd4be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2189","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:fd2eef7a-a206-4f07-b14c-4b5a50505cc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2189","original_object":"UniProtKB:Q00788"}
{"id":"57b0959a-2de8-4d00-9a4f-a99d280c9fab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PX9FTM69BF","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:0e058b1b-0d6c-45ed-a188-f41a1e15565d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11190","original_object":"UniProtKB:P16234"}
{"id":"50da7697-2bd8-44fd-952e-fd4f004d736c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:5eb2655c-0d7c-46a1-9985-e34d3ec3805d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P30938"}
{"id":"b8f36a5b-2e9c-4522-bc31-10fc9561d346","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1173","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:6836ef7f-c745-4cbf-ab00-23f96bcf29a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1173","original_object":"UniProtKB:P30968"}
{"id":"d53e9efa-eee5-47a1-a11b-ccdbe76d4b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27690","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:a344cc7b-f68e-471c-b36a-93ba6e4e7d50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6792","original_object":"UniProtKB:P00915"}
{"id":"a27f882b-e36e-4dba-9634-9e0384cf90ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z02T66W92D","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f8e754fa-ea59-4499-ada4-0a31f6cd2ae3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:427","original_object":"UniProtKB:P29274"}
{"id":"3e8ca1c3-66ac-492b-a23b-bd9bce27a9ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11460","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:a956167e-2f3c-4424-8620-f32ea8019b20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11460","original_object":"UniProtKB:Q9NSD7"}
{"id":"1a6be846-c096-48e6-a38f-e31d6c941f9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J2WIV0JMML","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:4b1e2cd2-cf0a-4ea4-abfe-08756cec958f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10652","original_object":"UniProtKB:P41143"}
{"id":"83f3b7d6-a494-4e66-ba51-ec26621b588e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52010","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:97431458-2a33-41ee-8897-11786039e61f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6976","original_object":"UniProtKB:P35367"}
{"id":"9e06c679-8609-4a0a-ad2d-3e61be9ee808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139474625","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:ad9b4147-95af-46a7-9518-29be99783165","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10526","original_object":"UniProtKB:P00519"}
{"id":"c62601fb-c7a2-46b7-845f-c7c4e30c16d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:8d9ae9a4-b410-456c-bcad-de113a1a6632","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P08173"}
{"id":"60ae344b-896e-4dad-a0da-95a6e6b8b801","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13850","predicate":"biolink:affects","object":"NCBIGene:80381","sources":[{"id":"urn:uuid:be424d12-6074-44b4-bc2f-fe396f7727ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13850","original_object":"UniProtKB:Q5ZPR3"}
{"id":"6518564b-7b8b-4c97-896a-59116fad8fb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918851","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:7481e7a9-4cd2-4039-b2b3-0edf82f2f4bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1337","original_object":"UniProtKB:P32245"}
{"id":"795f7c27-e189-427c-8b15-1212d51e29a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:246153","sources":[{"id":"urn:uuid:ed54e95a-f987-4111-a859-d9423eb30915","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:P22462"}
{"id":"513d0cc5-e146-42b4-b59c-374768f44875","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6852176","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:f3defc23-a2e3-4b90-82b6-10ded7b93657","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8908","original_object":"UniProtKB:P62508"}
{"id":"721703a8-0477-486d-b085-2c910f2edb5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90908","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:e8c6374f-39ab-4602-8f5f-c35b359bf7ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5749","original_object":"UniProtKB:P25103"}
{"id":"db21270c-ded1-48ac-8708-2b757c1d137d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:daff05c1-bfef-4c29-8ee3-fe389a23963b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P28223"}
{"id":"926b9104-c026-437a-b3df-3bb7468c33f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK8OFX8K7F","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:35af81bf-4c6e-4257-825e-ac78d5122ebe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9330","original_object":"UniProtKB:Q08493"}
{"id":"137f4377-65dc-461a-bea8-1ff888a76b3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821498","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:fcc9e615-d50f-43dd-88cf-38ad6da61a71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:167","original_object":"UniProtKB:P41595"}
{"id":"5a3b705a-809c-4262-bfc6-e5ba2389fd4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63450","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:77a1de37-9375-4d02-bc39-d0e723d4ffc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5656","original_object":"UniProtKB:P16234"}
{"id":"cb51c250-7fcc-47d6-ac7a-38c9a75d7b5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32168","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:265e48f9-47af-4bb7-b9a9-7dab892ec7a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5501","original_object":"UniProtKB:P43166"}
{"id":"80389cf9-abb5-469a-89cf-35f2f1a15a1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:91d7e4ff-93ec-4cdc-ab95-b3f7e8a0e2e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P30680"}
{"id":"06e05f91-4e72-4e52-9389-17fdf2add377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2630","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:21320f12-78a8-4666-8256-23a6a0d7b3ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2630","original_object":"UniProtKB:P15390"}
{"id":"e929697d-8e8e-4c62-97ce-86775938747e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54751698","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:8b83907d-ef9c-4d60-a91d-4f2e11c70de5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8968","original_object":"UniProtKB:P42338"}
{"id":"6284335c-71db-47ab-91c5-8ef95cab9f68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:55438","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:d1618d62-0cad-44e6-bf4b-ff5d732ef3c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:582","original_object":"UniProtKB:P50052"}
{"id":"fa80a1bb-2892-4996-90bc-c83cf7aea8af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64119","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:42e16a7b-caeb-484e-87ff-09fdfb5ba1d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:958","original_object":"UniProtKB:P21917"}
{"id":"7dd013f1-be64-4c59-8a9b-5269f260691d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146425702","predicate":"biolink:affects","object":"NCBIGene:50814","sources":[{"id":"urn:uuid:228e0974-16e0-4d7d-88ba-121694394d50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13566","original_object":"UniProtKB:Q15738"}
{"id":"c5e11871-b484-47b6-9007-db35116425a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229920","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:e137b712-d268-45dd-b236-078d5d9e4305","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2672","original_object":"UniProtKB:P37231"}
{"id":"e472481a-2956-4eb1-ae49-f0fbf18190a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233052","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:18148194-f857-4a92-b430-9e2b38793953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7501","original_object":"UniProtKB:Q13547"}
{"id":"539d471f-6510-497b-94ab-a4d7f6f05139","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76285722","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:abd52ca8-2c89-4b46-9e61-42eba529c5a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9349","original_object":"UniProtKB:Q04759"}
{"id":"b53c40d4-2641-4aef-843b-ee36cf9bbc88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317992","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:d544f0cc-bdff-4bf1-bd7f-4f31fcf21fc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3248","original_object":"UniProtKB:P28221"}
{"id":"c7c6a722-5435-4e9b-84c5-0fa747ec13af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4514","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:3c3f855e-0185-4426-a482-3038d21e745f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:355","original_object":"UniProtKB:P08172"}
{"id":"4657f8c2-1765-4d6e-928f-5d312c3c6ca7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4463007","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:0a9a4057-dad5-49be-a552-0e7f1373fe3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10527","original_object":"UniProtKB:P23458"}
{"id":"5833ea9c-518b-41e5-9179-2294885e8f20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111176","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:67d3e48d-25a7-4440-bc99-1e9b57fef3e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3296","original_object":"UniProtKB:P19020"}
{"id":"9a46bb43-712a-4183-be97-0b1d405480cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:f1827c06-3be9-4990-b58d-bf061000a81c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P31388"}
{"id":"cbf357b0-35f9-4657-bf90-fc0cb03ce324","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311462","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:de9de146-cdcd-438e-8d5d-3379b40e3eb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1425","original_object":"UniProtKB:P41594"}
{"id":"2d8a42d2-05af-45fe-a76c-6775d7984743","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130933","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:fbe8424e-8410-4732-bf5e-894ecc99db36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1007","original_object":"UniProtKB:P21451"}
{"id":"e4bb71a0-b039-4fe2-96c7-fae83193876b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197431","predicate":"biolink:affects","object":"NCBIGene:54257","sources":[{"id":"urn:uuid:07a98bf6-daa1-4575-92dd-a545547b1620","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4185","original_object":"UniProtKB:P42260"}
{"id":"c494f483-e77a-4143-9941-9de6f451f72f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5527","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:28f6ea7e-1140-48df-9235-d4bcc703d015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5527","original_object":"UniProtKB:P25090"}
{"id":"7436bed0-0b55-4556-a1c7-d6b026924aa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44560289","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:9f9e33e2-8010-4eb5-952c-214aa1dc5156","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3536","original_object":"UniProtKB:P32246"}
{"id":"91468406-d4ca-4340-bca0-ad4351f7562d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78413","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:9d863ad9-f8b7-4f61-a5e5-8bd5997483c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9396","original_object":"UniProtKB:Q5S007"}
{"id":"683274e5-4075-42dd-8680-ac83e132ff72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65326","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:7577c1d2-eb50-4f48-b83c-915821ae17b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5682","original_object":"UniProtKB:O00329"}
{"id":"f415a8d0-71a7-4221-8900-21fc8d592ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:bf1f26d7-831f-4cca-b9a0-e8fd9039f630","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P28566"}
{"id":"42064ab3-3bfb-4c2a-8b1a-cf38c25ad8ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11266452","predicate":"biolink:affects","object":"NCBIGene:117264","sources":[{"id":"urn:uuid:9e09ea1d-4736-4e3c-be6b-83b977760c4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1752","original_object":"UniProtKB:Q63371"}
{"id":"b60a49e9-0070-4165-9558-830008513b9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11185529","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:7735d72a-3e89-46db-98a4-30d2542c04c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7772","original_object":"UniProtKB:P49286"}
{"id":"24e29f34-db0f-4095-b563-b723042cbc56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137213562","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:6325cb4a-8763-4f40-8f34-bbe6966f7d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10676","original_object":"UniProtKB:Q9H2K2"}
{"id":"e99d84ac-f591-4e48-b01a-d76d3676451a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136045796","predicate":"biolink:affects","object":"UniProtKB:P0DPD6","sources":[{"id":"urn:uuid:e9add649-fed0-4bba-bd53-f02b1a2013ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8673","original_object":"UniProtKB:P0DPD6"}
{"id":"367633c1-f9c0-4590-b8cb-da089d19925f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679361","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:92138e60-3c6b-4bec-a4d7-8c2154b53f63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11853","original_object":"UniProtKB:P35414"}
{"id":"84a4bdc0-0276-4802-94f6-892760b74f73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817418","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:ec0a01e4-f03d-4f07-8fa0-4df129ac36fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1510","original_object":"UniProtKB:Q63634"}
{"id":"9c2a0bb4-ad53-4c7f-a476-43c15dc67d11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:093dc57a-385d-4e79-ae3e-3e941d038046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q9H228"}
{"id":"a0a48f36-9c68-415a-95f9-5b06c184ed66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10062394","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:92acfc74-6af5-4032-ae74-8ee71bd0fa00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:304","original_object":"UniProtKB:P11229"}
{"id":"ce1e5cd8-c9c8-429e-b091-712814cf6120","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6099","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:fd5c4e0d-f3b8-4872-8125-ebdaa1505127","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6099","original_object":"UniProtKB:O43603"}
{"id":"0cc340af-c43c-476f-a292-658442e7ba90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59053926","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:b9d40640-fdd0-49e8-8a0e-c194ba803cc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9831","original_object":"UniProtKB:P56817"}
{"id":"6661eb2b-ba89-4816-917c-a45048048419","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3964633","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:d0a8071c-065a-4046-9ef0-9114dba26d62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1398","original_object":"UniProtKB:P35349"}
{"id":"ece327ba-a63e-481a-947b-da7e3eed9a12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:60325","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:9a1bbb8b-8357-4f38-b2aa-1f47bf58baf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8057","original_object":"UniProtKB:O00444"}
{"id":"6f1d8e1a-f7c3-413b-a637-67b7d5cbb70b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32181","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:fc007104-b2bf-4d23-a90b-0f9b333aa4b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2648","original_object":"UniProtKB:P10276"}
{"id":"71fb5a79-9c82-438c-a8d7-2fdd39f7187b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:2d6a431a-649d-46de-894b-8affa696c270","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:Q14832"}
{"id":"ec1ff3d3-a57b-4cc7-8cd0-21853bf99d8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:0aef5265-80b0-4111-bf28-5e4b0d48cee3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P18089"}
{"id":"54284a9b-5bed-4597-93c1-c6c4ed251ec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10062394","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:ec6d65fa-9956-4e56-93bb-9cef99a162ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:304","original_object":"UniProtKB:P20309"}
{"id":"7a6391ac-d4f2-49a0-a7f1-1b0c1b83e620","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8R6ETA52F","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:770b61f0-fba4-407d-8c39-8973f3dc1bd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12612","original_object":"UniProtKB:P00533"}
{"id":"7324791d-4b91-446a-85a8-9dd6f6a8a202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24763119","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:3603e97c-a226-4b3c-b365-306e61805a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6416","original_object":"UniProtKB:P31424"}
{"id":"0253cb8d-5eb3-4b36-a1ae-d127f35059b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10113","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:74f13ba8-011d-4c17-b033-17b1b66e467a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10113","original_object":"UniProtKB:P30874"}
{"id":"158c2c61-0c91-4fdc-9149-fec754b12c9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EW71EE171J","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:9a1fe820-74f7-4a65-baf7-c0777022d892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:185","original_object":"UniProtKB:P28223"}
{"id":"482b3c79-834e-4104-8b26-d296a81afc86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5856","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:8f3d2f52-642e-49d3-a281-c4a8ecc57683","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7200","original_object":"UniProtKB:Q12809"}
{"id":"401c1296-9f99-4f08-af53-47623607a249","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32168","predicate":"biolink:affects","object":"NCBIGene:759","sources":[{"id":"urn:uuid:91ef2f99-f6c1-4fd4-a8cf-70fc541f448a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5501","original_object":"UniProtKB:P00915"}
{"id":"600c3eca-65fd-4957-840e-27644e420c92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U6LA7G393X","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:585f0e3c-9e26-4b82-8112-c0279dcd5baa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9276","original_object":"UniProtKB:Q9H3N8"}
{"id":"58c40bf9-246a-4450-97f3-a5e9c2c79d73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:927","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:3cf1007b-2bad-4178-9d56-c3be61d6c3d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:927","original_object":"UniProtKB:P47866"}
{"id":"fda51e71-42fd-4d82-9e62-832ae6f29a71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1219451","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:c47ec2e0-49fb-4c25-9039-7342752135db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6387","original_object":"UniProtKB:Q9GZU1"}
{"id":"f65c969d-8732-4c42-97b1-b2672c42477a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3655","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:cc7d869e-d5ae-4a98-a17a-a73dc2aa1740","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2322","original_object":"UniProtKB:O15554"}
{"id":"81c319bd-c0fe-4e7b-b3fe-c2f909a1e4bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GE2T1418SV","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:109d548d-8e5e-448c-866e-4e5dbc88d144","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7354","original_object":"UniProtKB:P08172"}
{"id":"fb2a3d77-9e38-4282-a548-a720489f2851","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947013","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:8aa63e99-a77b-44f6-a44f-3a4711bc7244","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3125","original_object":"UniProtKB:P37268"}
{"id":"f03b4278-2250-4b0d-968b-4002f6fb243a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3878","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:e7c146c7-20f9-4b34-a6a0-1a60f843b87c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3878","original_object":"UniProtKB:P30968"}
{"id":"a1c310a9-870b-44df-aade-db6055459023","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1568","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:1f9f372e-5e94-49cf-b378-2bc99fc8e439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1568","original_object":"UniProtKB:P30989"}
{"id":"93c39833-3cf8-4bec-af02-2b7ff1b0da15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10124389","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:02009fda-d7ce-4d80-96eb-6fa3a2aa2dbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2175","original_object":"UniProtKB:P47901"}
{"id":"0b31f3e0-8fad-4acd-bcb6-66177c00d8c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50730","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:b5f33762-0153-4e0a-94ca-1f3856686f47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3340","original_object":"UniProtKB:Q9Y271"}
{"id":"33ec3b11-6748-4670-8cf5-438f962d6774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9794656","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:be16ee50-d5a6-4e04-9195-ec0b7f7b1244","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:171","original_object":"UniProtKB:P28335"}
{"id":"9079158f-1aa1-42e5-8f28-ec4d7364698b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:e7266c91-dc07-4f43-8c8f-b083a965b3a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P24046"}
{"id":"6c28312c-0430-43b3-a44e-1d27a8ea8bb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:3783","sources":[{"id":"urn:uuid:8cc55fda-2ff3-4fea-b729-0168ecceb068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:O15554"}
{"id":"273e1df8-a948-4406-812f-6b6c3d4ea9ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:581a3251-58bf-4413-b560-6eef5ef1ff53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P28221"}
{"id":"c3c714f6-5735-4029-95a1-f9e6df80cffb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64191","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:718179e6-5314-4fe9-9966-2f7171aeb9ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:44","original_object":"UniProtKB:P35462"}
{"id":"fa1c4d5f-5ce1-45d6-85cf-66ba723c4830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91933514","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:768bec12-6971-4353-bde3-1823a017a0f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3915","original_object":"UniProtKB:Q16581"}
{"id":"feac2d65-72b8-43a4-8677-d136f70b68fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4162","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:7fdc92ec-a84f-4877-b331-1ed8c949bf20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4162","original_object":"UniProtKB:P39086"}
{"id":"5b44f2df-325d-438c-a780-f7db95ef1091","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:862491bc-2446-48d7-94e0-82603b63e935","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P50406"}
{"id":"6e2f1cc9-db7f-4a9b-8c0e-6b57684f0aa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431484","predicate":"biolink:affects","object":"NCBIGene:14073","sources":[{"id":"urn:uuid:b0c0e71e-35da-41dc-a5d0-598b99ab3c21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10124","original_object":"UniProtKB:O08914"}
{"id":"6ea4ea2d-74b9-4ae4-bd55-85a9ae97c074","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69921479","predicate":"biolink:affects","object":"NCBIGene:9293","sources":[{"id":"urn:uuid:521f7c68-7a7c-4369-9c87-aa23e4d09946","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9804","original_object":"UniProtKB:Q9Y2T5"}
{"id":"03a5c40c-bb61-4a6c-8330-e9d64cc1a245","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:ef0b1a6f-0979-4b74-ad8f-a60fea1bced3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:Q62805"}
{"id":"cccb499d-4089-44fc-9923-ec4b742bdade","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587566","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:3306f73e-45c7-4b6c-a025-372a4e381b57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11689","original_object":"UniProtKB:P35354"}
{"id":"ff707b1b-603a-4e93-8a53-f3680ed67135","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O0N0E1MP23","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:150a406f-935f-4dd4-b27a-c59e7274e58e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8142","original_object":"UniProtKB:P17252"}
{"id":"1572595f-1495-4b80-811d-d6110a494e5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L7BVT4Z4Z","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:4cfeb249-dd37-4215-af20-20f75c481e19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4343","original_object":"UniProtKB:Q8R455"}
{"id":"b125d4e4-ba96-4c04-a890-1db6969e44d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90469849","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:9695f335-3b38-482a-b25b-7afce30cef4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6088","original_object":"UniProtKB:Q62805"}
{"id":"76f8b31c-d0ab-425e-9404-4c04949ba79e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45783","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:dc3b707d-ff81-43ce-ab77-c5daeedd8937","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5687","original_object":"UniProtKB:P00519"}
{"id":"161e675c-0a7c-4f1a-80f1-e72112d11a75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8267","predicate":"biolink:affects","object":"NCBIGene:972","sources":[{"id":"urn:uuid:41ede6c5-fc26-411f-91dc-34f53dd791b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8267","original_object":"UniProtKB:P04233"}
{"id":"790c57b1-c9b1-474e-a04c-2f01dd2ae8f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:22064","sources":[{"id":"urn:uuid:0623a3c9-3cd4-431a-a2aa-c43e57738f67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9R244"}
{"id":"95784e7a-63f6-42d2-8840-84cc5ce09a55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57504987","predicate":"biolink:affects","object":"NCBIGene:4217","sources":[{"id":"urn:uuid:2c549ba9-3384-40e6-b5bd-36ab0ac8c871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10430","original_object":"UniProtKB:Q99683"}
{"id":"f42d8613-88ff-4345-befb-481477679e90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91370","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:e2f071f1-219f-44fb-9158-2309274b0874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9381","original_object":"UniProtKB:Q05397"}
{"id":"2786d5a6-5bc2-4bff-b6c6-5a6127886ea0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:1d93d2dd-7b88-4168-a902-8ba2a5b49213","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P14867"}
{"id":"b51f968f-a1eb-423e-a8cf-5d1650a3238a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:e64d278a-accf-4698-a85c-61d68a09e75d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:P48050"}
{"id":"9ba3fa6b-9162-4a64-a82c-8fa80036d890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G6GSO9SDNJ","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:b1c4f3f6-b1b8-4b62-a104-777d08254b6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9852","original_object":"UniProtKB:Q07343"}
{"id":"8790db91-4b95-4875-8162-a623fb27fd6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:4a750a59-4077-49cd-adc0-c2158778fd8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:P27338"}
{"id":"518a234c-50ad-4d45-88c4-6fc96d3928f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754999","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:1fe709bc-2520-4619-8bbb-a710a8c13fed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1186","original_object":"UniProtKB:P30968"}
{"id":"5ba044ca-c54b-4416-95da-7da148157a4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:f7296899-52af-466a-ba22-99b87e8166b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P24941"}
{"id":"f6ead667-2dde-48a1-8860-52b833906623","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433292","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:eb4e0567-3c9e-4ede-bbf4-dfcdb50d4939","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12655","original_object":"UniProtKB:O15552"}
{"id":"7659ad83-20d8-41c2-a898-8aeadd37494a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:53373","sources":[{"id":"urn:uuid:45c27730-4cce-444f-ad06-e4164f750aa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q9ULQ1"}
{"id":"3472218b-29c7-4ee5-bd45-87124be042f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24892831","predicate":"biolink:affects","object":"NCBIGene:5652","sources":[{"id":"urn:uuid:7e502f2a-ab1b-48c9-9eeb-7fec60a4d96c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7859","original_object":"UniProtKB:Q16651"}
{"id":"d70e6d3e-730b-4058-9ada-71e1cf0ef466","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK8OFX8K7F","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:efe6ec69-7be3-4957-ab59-911a073cc0c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9330","original_object":"UniProtKB:P27815"}
{"id":"1becf451-81c4-47b6-b53a-7ec14582b746","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:ebba88bc-1229-456a-b56a-e22193917fe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:P42338"}
{"id":"252c68b7-ec4b-4cc1-a0e6-20a1c70eb44b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44457307","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:1e2df87a-f3af-4484-a1cc-aea74f1da606","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1746","original_object":"UniProtKB:Q15077"}
{"id":"00cb2209-f626-47e5-b0f5-278701f64808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3360","predicate":"biolink:affects","object":"NCBIGene:29465","sources":[{"id":"urn:uuid:33d1634e-611b-472f-a183-4ce1175146e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:740","original_object":"UniProtKB:Q9WUD2"}
{"id":"f87e56a1-8ba1-4645-9e4f-9b1f5faeb54c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9875034","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:a19cc229-1218-47ee-902f-3929d895869c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2106","original_object":"UniProtKB:P21452"}
{"id":"6b6cc5d3-f7bb-4f84-92e8-4c23cb1740d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6717","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:4a8326e9-9b72-4a95-8ad7-6b744d3957b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2593","original_object":"UniProtKB:P51787"}
{"id":"0648c656-7c9a-4ed9-b144-d6a7cbab4bc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KZ1O2SH88Z","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:cb1a01bd-6ff9-4141-901a-b8ef53e94cba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9892","original_object":"UniProtKB:P27487"}
{"id":"4f483edf-786e-41ff-9d71-3d0725d01d8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60210951","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:77c500a0-927e-4e6b-9f11-699bc5e12bee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6931","original_object":"UniProtKB:P56817"}
{"id":"b8e7e702-3f4c-4974-804d-e4da7f2b5008","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14372618","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:6b7a74cc-652e-49ea-9c38-daaff4db4b27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9878","original_object":"UniProtKB:Q08499"}
{"id":"93855098-a590-4739-a174-44cb4d56fe12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WJA5UO9E10","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:ca7f3b50-d9fe-477c-811f-d68890f96979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10629","original_object":"UniProtKB:Q06187"}
{"id":"2ce5a987-1019-401b-babe-9b668bad435d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131039","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:f8803a4a-5a30-4f73-bd01-54700b1cd3ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1587","original_object":"UniProtKB:P70310"}
{"id":"128580b7-7f12-4864-beaf-a8da7b6c2b0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16739288","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:884af147-5c93-4967-a1e1-e6c5cadf9272","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6358","original_object":"UniProtKB:Q13255"}
{"id":"96c77b1c-4e26-44e4-87ae-bced1aa0626c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:6196","sources":[{"id":"urn:uuid:bd73eb77-84d0-4fa3-99fa-207a2383dd7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:Q15349"}
{"id":"80385723-5520-45bc-8b19-0e7dd58f50dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1512","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:2bc9a3ee-6e2c-4e32-974a-8b8bbe5eb0d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1512","original_object":"UniProtKB:Q63634"}
{"id":"d0044721-1cc8-4911-8a32-efd487698f93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189662","predicate":"biolink:affects","object":"NCBIGene:8317","sources":[{"id":"urn:uuid:cd7c5dbc-e630-4e5d-93bc-5ead27026112","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8113","original_object":"UniProtKB:O00311"}
{"id":"bf3cc56e-e9da-4357-bfbc-892e75814ca1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232605","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:9545748c-7428-4a51-bcb9-4f7e0c2ad023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12792","original_object":"UniProtKB:P10826"}
{"id":"ed9b5622-be21-459b-923b-7c64db7ae3b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121328278","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:1c073886-6dd7-4ec9-8962-f7f5538de949","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9707","original_object":"UniProtKB:P14902"}
{"id":"6ecb53cb-9c21-4dea-a818-ff377f086cdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94609","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:6650fd1d-9774-4096-a39b-45167d4a4d2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:356","original_object":"UniProtKB:P10980"}
{"id":"a776db5f-c13e-44c6-aa8a-7f10e57246c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:697","predicate":"biolink:affects","object":"UniProtKB:P31392","sources":[{"id":"urn:uuid:868be4bc-9be3-48ba-baba-643509a78c04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:697","original_object":"UniProtKB:P31392"}
{"id":"7337fe74-d2f0-49c4-b5a9-a64345e5035b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13925","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:75635ebf-8868-48db-9de7-28fc0d26e412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13925","original_object":"UniProtKB:O14842"}
{"id":"5ce3c7be-05b7-4aab-80c9-43f5035de0b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5289418","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:44227e2e-213d-4045-829f-9d078a6d58a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11743","original_object":"UniProtKB:P09619"}
{"id":"028d8860-3484-4b85-a5d1-4233643e7793","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231369","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:44960154-dd96-46b8-b616-dcae3482b03e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9918","original_object":"UniProtKB:P08581"}
{"id":"afed917e-9e91-492d-96cc-e26a01b06dc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92140","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:649b972e-cb56-4ce9-a6b3-b5d839c3cc70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4240","original_object":"UniProtKB:Q14957"}
{"id":"5e333c69-b37f-4636-8ed0-9ffaad9d70c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155097467","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:fbe1558f-01d0-465a-b0d8-232839a2d1dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13748","original_object":"UniProtKB:P25101"}
{"id":"5c810c42-f343-4633-ad0a-c8e2c5b9c279","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38073MQB2A","predicate":"biolink:affects","object":"NCBIGene:1454","sources":[{"id":"urn:uuid:994b24a7-9236-4b44-b4ee-2f990e15a371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8916","original_object":"UniProtKB:P49674"}
{"id":"b2afd599-330d-476d-9aa1-6cbb0c4a1cf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:0b56a2b9-a4ae-4583-8765-b34244291fa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P28647"}
{"id":"d15e837f-2d71-4338-a47a-c440e10f2692","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2037","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:1e744d39-b9a1-4972-bc80-5840427a7e25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2037","original_object":"UniProtKB:P35346"}
{"id":"d715a354-0159-4489-b549-b3f043e46913","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75390","predicate":"biolink:affects","object":"NCBIGene:19013","sources":[{"id":"urn:uuid:00448c57-1e92-4292-9a5d-2dc08549a410","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2655","original_object":"UniProtKB:P23204"}
{"id":"cc523e54-33ab-487c-ad48-312337daffa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:56f7d457-e826-46a2-b2d7-8166e4226290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P41595"}
{"id":"fc5676b6-5f9d-4f95-b929-d2e497c8ea4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:76IND1BS43","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:98775615-0dea-4bf4-9f68-382d01a7ef03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4154","original_object":"UniProtKB:Q12879"}
{"id":"205ea1f8-c066-450a-9f20-930678960259","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R0T9LLR4TN","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:5507961e-bf20-4c75-8a88-a6460eadffbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10653","original_object":"UniProtKB:P51677"}
{"id":"a06d280b-e1ec-46c6-a1ce-1945e1347459","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9810391","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:d5d47273-89b3-4ecc-8179-281672633c56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:673","original_object":"UniProtKB:P30411"}
{"id":"86415806-c2e0-439a-b40c-1630ea1bc172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156297592","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:933d96e4-c6f9-463e-8aca-f058f1ea98fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12095","original_object":"UniProtKB:P04049"}
{"id":"f8340e35-b220-40aa-ac87-a6ef9d0672c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755250","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:b89abf49-7e41-49ec-aaaa-357af5577390","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6917","original_object":"UniProtKB:P30556"}
{"id":"7333b827-7323-42ee-8302-3f179d31c796","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30768","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:a7b0e2a0-e330-4325-b14a-8d5c4cfaf41c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1062","original_object":"UniProtKB:O14843"}
{"id":"e66ced14-2c88-42bd-965e-82f8278af97b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2614","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:da2722fc-ca85-44f0-8be3-6302b3f4af60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2614","original_object":"UniProtKB:Q9NY46"}
{"id":"59a780d5-743a-45b4-b415-24702c46c226","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138488","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:7fbb25d7-7a4e-4ac2-9c35-b4a01ab8876b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5925","original_object":"UniProtKB:P49841"}
{"id":"2c8329f1-60db-4858-b19a-b8caac63fe76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6754","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:ca4db62f-5ca1-41c2-88ea-20859fc15ccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7221","original_object":"UniProtKB:P41145"}
{"id":"f4e4f6ce-885e-43fb-98ef-6c3186c9564e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311213","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:4fede0ae-6d11-4c8b-9072-78aa32ba97b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1898","original_object":"UniProtKB:Q13258"}
{"id":"a1a0b822-ea17-44c6-a47b-723ba65250c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2873523","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:d7cd1cb0-6513-4a6a-8b69-45bebd79961e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6276","original_object":"UniProtKB:O75762"}
{"id":"0cdf9621-92cb-4b4e-9f7b-5a1e380c3d04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:fd80967a-78b4-4886-815e-7bf979af9562","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P43119"}
{"id":"fcbd852f-90ac-4a16-a9a3-f675d737b6f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49960","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:41d56d3d-e180-4c7b-be83-9adb9fccf9ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5717","original_object":"UniProtKB:P07949"}
{"id":"67e3a8f7-bd79-4bff-a131-5135f8233ce0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:76678bd3-ebdc-4e9d-95d6-b52d3301964d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P28223"}
{"id":"84e5ab78-e0f2-4220-8493-4660a47787e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:625","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:a59d6dc8-4cc6-443d-a6e4-80ba1b509770","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:625","original_object":"UniProtKB:P30550"}
{"id":"2b874c5a-a8da-4fb3-bf30-167f7df0a5a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4806","predicate":"biolink:affects","object":"NCBIGene:54429","sources":[{"id":"urn:uuid:dfc71466-7bf6-4f1c-ac74-fd970773663d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7002","original_object":"UniProtKB:Q9NYW4"}
{"id":"9a701f73-134a-4980-aab7-7150024b0172","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11552757","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:78fa6885-e27c-40da-9b2a-b03681ba8814","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4712","original_object":"UniProtKB:P48067"}
{"id":"8d50b32d-d076-48b4-a84b-6dcc81ca147d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433309","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:27767225-55bb-485b-b331-f7e37335b583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12806","original_object":"UniProtKB:P09874"}
{"id":"7ed0e48f-1302-4996-ae96-0c0126d7ed13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:9e3811db-4d03-412e-9a6d-a4e801e3d7c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:O60674"}
{"id":"09f7da92-6605-4052-9e6c-9826164e7c77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:93160b4e-1f17-47b5-92a2-d01d8b059773","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P28335"}
{"id":"d0e1dfd6-d432-4645-990e-0955412279eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15760","predicate":"biolink:affects","object":"NCBIGene:113914","sources":[{"id":"urn:uuid:c7db2bad-1408-42ea-81e2-55d1cee98042","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2150","original_object":"UniProtKB:Q923Y9"}
{"id":"e1137485-c1be-475b-9f13-5918550b22f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:0a41d140-0d12-43f9-93c0-506c24e614a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P35916"}
{"id":"fa9a870b-74c8-40a5-a745-41c2a8088813","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:819","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:baa0cf03-0e60-4fc0-8e3a-6277e2829b19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:819","original_object":"UniProtKB:P25025"}
{"id":"3a2432ff-9574-46ed-b1b2-a5483b3ac0e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:667594","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:f341fc6d-9f53-4da6-b642-34b9b4beabd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4309","original_object":"UniProtKB:Q8NER1"}
{"id":"34a3b87b-646f-4ed9-861c-705aec5f9bcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183514","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:0c6519bf-44f4-45aa-a8cb-ea7b99897a9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9583","original_object":"UniProtKB:P22001"}
{"id":"79b963d4-c8ee-4c27-97d5-f67b3b3124ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817516","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:de0c06e0-9ca0-4583-8bd0-dd66a271139c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11425","original_object":"UniProtKB:P29597"}
{"id":"51d35076-74d5-408d-a3d2-402209a453af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5841","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:4610de55-f0ef-4c23-bbf3-0b19e1d2c28f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5841","original_object":"UniProtKB:P33766"}
{"id":"52bd16c1-6449-4247-b405-b4439b7da03e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081969","predicate":"biolink:affects","object":"NCBIGene:18606","sources":[{"id":"urn:uuid:9c8f51d9-82c7-4fe1-8ed0-009348ea6dcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9898","original_object":"UniProtKB:Q9R1E6"}
{"id":"4713996f-f2fb-411f-afef-93b92cf0871b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91407","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:c16fa3cb-c9c8-4373-90ad-a92f149a6386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7791","original_object":"UniProtKB:P52333"}
{"id":"910ec63a-03a9-4fa6-ae61-6cb30a345cbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6CE2107J4T","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:271504e3-1674-48f0-8633-211c124262d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11676","original_object":"UniProtKB:P00533"}
{"id":"b9f8025b-2fa2-4fa8-abc2-64e089c4f212","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4953","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:3f9b1176-be65-45cc-93c2-d8f11d1e3754","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7073","original_object":"UniProtKB:P11511"}
{"id":"30d68c7d-2af0-4edb-931a-309bc2a0825e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:49e00eba-81ff-4958-bf4c-fffad0bed4a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P28223"}
{"id":"41dc700a-b011-4d8c-a645-e4d7e3e610f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2NL79NI1WS","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:cacf2079-9701-41eb-ac2a-45748aeef1ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8799","original_object":"UniProtKB:P11511"}
{"id":"f38d01d3-6b2c-487b-b8b3-6740938cf5e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3077","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:1436f423-8c93-4b29-93ae-5fc78f26c4c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7061","original_object":"UniProtKB:P04150"}
{"id":"0a044dd2-654b-4e8c-ba23-ce32695f6512","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL270960","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:f343f9ed-43a6-4346-9e4d-3c800b8ecb54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2678","original_object":"UniProtKB:Q07869"}
{"id":"3d2a6817-7af8-4aba-ba24-b74a33761970","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5897","predicate":"biolink:affects","object":"NCBIGene:170641","sources":[{"id":"urn:uuid:3fc53b3c-c67e-47f6-b4a1-552809b0d503","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5897","original_object":"UniProtKB:Q9Z173"}
{"id":"45a1a12b-7d56-439e-a471-88ad5641fa28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YB1F0V77MK","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:9ff058b2-2858-4f50-8e95-b70da3f41a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6155","original_object":"UniProtKB:Q9NPC1"}
{"id":"86183f76-536e-4d09-92bf-01fcc523ac0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:6cd91a83-9812-4329-a1aa-6cb2481be251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P28223"}
{"id":"547567ab-5cff-457a-9e1e-8787108f7907","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34823","predicate":"biolink:affects","object":"NCBIGene:29682","sources":[{"id":"urn:uuid:7482c5eb-d5e9-4fdd-a727-21ffb921758d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2599","original_object":"UniProtKB:O88944"}
{"id":"51a2a73b-5fc0-4685-ac25-7c44a4ec5db2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:216449","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:0d583a74-5e52-4244-812c-d2bdbf14babd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3069","original_object":"UniProtKB:Q02769"}
{"id":"73b1c8b9-5de1-40bf-99c2-f95fdc914b39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:844f7667-e727-48e0-b2c6-8cac64cf470c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:O14843"}
{"id":"5c46b3a8-7299-4123-a528-9e7a3c621936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:420a5f8a-ab23-438d-93f7-6415bfca69fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08173"}
{"id":"a4d2c8f1-91e3-4819-a477-d3dd16410ec6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996520","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:ecdb8631-7bbd-4e01-840e-5f5478a7678a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10581","original_object":"UniProtKB:Q9NS75"}
{"id":"ca1a0bf4-c16d-47f8-9d33-758f86c58069","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:353192","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:e718218c-9109-4846-b13a-bfd73321589d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11240","original_object":"UniProtKB:Q9HBA0"}
{"id":"9a837017-403f-43cd-bf30-81a02d728b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57468154","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:d0fa6a7d-a507-456a-acc7-d000ee1df0d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5453","original_object":"UniProtKB:P47900"}
{"id":"2cb26cb6-c319-43e3-a438-21b001938194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32111","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:9ba1c394-73d8-4571-bee7-64c63ebe8f15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5432","original_object":"UniProtKB:P59538"}
{"id":"fad260aa-89c0-47d8-9a3b-6a996990d61c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131347","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:50717364-2c8f-4e3f-9ed4-cbee8ea0e314","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4065","original_object":"UniProtKB:Q01668"}
{"id":"e66466cd-25dc-4377-a032-90dc0ea1151b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:f93603ac-8297-445e-a9f6-1010d52c47c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:P35498"}
{"id":"24a0c5b8-b94d-4189-b8aa-ed2e25d782e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4975","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:473f6232-a9bc-46ae-a828-48063eba5236","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7074","original_object":"UniProtKB:P59538"}
{"id":"8c0fd647-37e5-4535-ac40-d66032833a5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95170","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:1076ab66-bbce-45f9-a878-7edfe3d66de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:351","original_object":"UniProtKB:P08172"}
{"id":"ca515ad3-808e-4548-8931-f9fadfd46ff3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71940","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:2bdb9115-9871-4a6e-ba5b-8ee83a900f7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7299","original_object":"UniProtKB:O76074"}
{"id":"20ee6931-2d0a-4890-b0fc-67b03ce38d99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31899","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:6e2bac80-27cc-49c4-9716-853d787bff44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:962","original_object":"UniProtKB:P14416"}
{"id":"23c23c1c-73be-4278-9e26-7ab584df9c61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553158","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:f767f691-391e-4d4c-be24-7cca4b6d2dcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10217","original_object":"UniProtKB:Q9NYA1"}
{"id":"08f30863-e29d-48ae-a221-ac7960635e48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140980","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:f38e5a5d-5e14-4d0b-910f-d302c554564f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1486","original_object":"UniProtKB:Q9GZQ6"}
{"id":"336dd975-50cd-4246-a22b-a529681f9905","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11530404","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:ccbe11f7-ce6a-45be-9f65-364a46784af1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6211","original_object":"UniProtKB:P23385"}
{"id":"e5424698-48ac-4164-b706-2b7d793b1541","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:543K8ZN6LH","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:1b025472-0bdf-4224-aefa-3f940bdb02fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8009","original_object":"UniProtKB:O15530"}
{"id":"bd0ba73d-90d7-49b9-89bc-9386b03e3165","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4RA0KN46E0","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:37460022-7970-447a-9021-69f662c33bf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9246","original_object":"UniProtKB:P23458"}
{"id":"c9d3fa70-778c-44b5-a5b4-1734ce89b4be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177647","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:5ce30707-7db1-4214-af5a-f806258c8f89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5604","original_object":"UniProtKB:P29274"}
{"id":"450e3aab-d2e0-4fa6-98a5-df10f24a5000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90642938","predicate":"biolink:affects","object":"NCBIGene:10196","sources":[{"id":"urn:uuid:3a5dd53b-d1cc-476e-9ac6-9a5f1569b583","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8552","original_object":"UniProtKB:O60678"}
{"id":"d7c3099e-e243-4ff1-b34e-106d6929f626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45486355","predicate":"biolink:affects","object":"NCBIGene:5122","sources":[{"id":"urn:uuid:f2ff95c9-a255-438b-8329-3e066a4faa7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6564","original_object":"UniProtKB:P29120"}
{"id":"e601f980-fcd2-4a36-bca4-db517f1ae22a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8416","predicate":"biolink:affects","object":"NCBIGene:3164","sources":[{"id":"urn:uuid:827d8919-9de4-4465-916f-a9bcedeb776c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13530","original_object":"UniProtKB:P22736"}
{"id":"8ebf6d36-9509-432e-8aa6-269b2dea30e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:851NLB57HQ","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:48627b59-9a53-4f2c-b5d6-a104c50606cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1225","original_object":"UniProtKB:P35367"}
{"id":"feb1c592-1e7d-4125-ba81-10e43f5eee52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2195","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:ec36c55a-d7e8-408b-956b-5c2252e8c795","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2195","original_object":"UniProtKB:P47901"}
{"id":"cb36042d-fdbf-46ba-a746-f500c8f1ab4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167729","predicate":"biolink:affects","object":"NCBIGene:51305","sources":[{"id":"urn:uuid:a967dd71-f710-4a55-8506-839bcdcce39a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2506","original_object":"UniProtKB:Q9NPC2"}
{"id":"67f18877-b744-4b8f-9e34-baa5dbf8077d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:834YJF89WO","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:ab60735b-b4c2-4c70-8b7a-6670af0aa203","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9558","original_object":"UniProtKB:Q13464"}
{"id":"39b4b736-48d4-49d0-8c9b-d7c3bba95934","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135355847","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:c5dfe7a7-4bd3-4bb2-afcc-8eaf40346327","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11203","original_object":"UniProtKB:Q06187"}
{"id":"5871d845-2a9a-4752-b1c2-fa024a3c585e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44370656","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:45bbb015-fb39-40eb-b918-3d9c4a35720d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3131","original_object":"UniProtKB:Q02769"}
{"id":"c59c2d68-78a9-49f8-9f12-c711195ac342","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8K8XT2KBG3","predicate":"biolink:affects","object":"NCBIGene:1147","sources":[{"id":"urn:uuid:9a7e5c13-45f4-4d46-8ca4-c5ceacd10e17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9398","original_object":"UniProtKB:O15111"}
{"id":"99abee5d-54ad-4a8e-8c0a-22407675aa7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433299","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:649ba23e-d3df-4698-9557-d87c991654ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12728","original_object":"UniProtKB:P42866"}
{"id":"2dc1e422-31b3-4d45-9d8d-563e4b67f868","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A5595LHJ2L","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:1147b67e-7b01-491e-84bf-791f4a8dc85c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12644","original_object":"UniProtKB:Q99250"}
{"id":"208c33f5-856f-4368-87ee-2a4a04f327c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:146243","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:74da1431-fb12-4994-ac3d-84a3d24e8e9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:747","original_object":"UniProtKB:P34972"}
{"id":"f1a3a864-b3a2-4325-93d0-942fe44ead32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44405630","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:f6776a53-d30b-4c30-87eb-a9baa4da2082","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6147","original_object":"UniProtKB:Q9H244"}
{"id":"f395bc58-c932-4183-860d-7ea91f8153fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:56302","sources":[{"id":"urn:uuid:92afc9ce-2f4e-4d46-9fca-414816b0d5da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q9NQA5"}
{"id":"50591605-ab3a-4f37-b3b7-a3f9b366b621","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78510","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:92f9289d-4540-4522-980a-e13d72c032b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4907","original_object":"UniProtKB:Q15418"}
{"id":"22af348d-ad7d-409d-b23c-969ccdfb4029","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67559","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:c0fec281-97e1-4c7d-84a1-92cfa6d1eb5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8077","original_object":"UniProtKB:O43318"}
{"id":"269afc5f-fa2b-4086-8040-c6e902b53e3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135005","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:0047eaa7-aa75-4568-92a2-041fc4c0a904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7436","original_object":"UniProtKB:P31645"}
{"id":"56a10757-dfa4-45ec-8a62-b9ccdade5544","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51098","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:49baca5a-71b7-456d-a216-671024ca65f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5660","original_object":"UniProtKB:P17948"}
{"id":"2c903d38-4ace-4a83-be4e-7099958df8da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71727383","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:5f5a8719-2aa0-4df9-93db-e13b512ac9fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12394","original_object":"UniProtKB:P30968"}
{"id":"2fcd116a-1b34-4d61-8882-86049ddc9aa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:1bb91cba-f7f5-4bf5-abaf-5d913924743d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:O15379"}
{"id":"31af19f4-87ba-444c-b63d-cfa2bcdfa097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:168SF9F04E","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:1eeda80f-d3f8-42cb-8b7e-c1060089d3c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5617","original_object":"UniProtKB:P0DMS8"}
{"id":"1acf1f73-0449-4841-8f40-dcd5d6f1ab4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5572","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:c87ec4c7-9a75-449b-918d-26897c10a083","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5572","original_object":"UniProtKB:P70555"}
{"id":"6dea4e89-4145-400e-b393-8bca4c4dd6ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68649","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:8df9442d-8f71-4063-adeb-55b9c3c8b5fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2169","original_object":"UniProtKB:P47901"}
{"id":"1f3effb3-f43e-4b73-9e28-e66f7f985f94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32347","predicate":"biolink:affects","object":"NCBIGene:79246","sources":[{"id":"urn:uuid:35d28592-0c0a-4ad5-b920-e76fa0b96e97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2287","original_object":"UniProtKB:P35563"}
{"id":"c7120b82-316e-40ad-852f-0cc3425006a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:a95b7c15-52a4-4b62-bbac-1eb602f4a70d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:Q9BWU1"}
{"id":"c5618b1d-fc06-44a1-a2b1-3d5a372907da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:d4e33d19-8c6c-436d-94be-3b9dbc34a22f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P35916"}
{"id":"b7203ee8-b600-4d42-ae94-1213b37380d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5634","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:10b0d18c-95b2-4fc6-b70d-9993dcca35f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5634","original_object":"UniProtKB:P30874"}
{"id":"66ceb6ef-8dde-4af9-ac18-222c82138ed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2684","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:9cfef100-c511-4939-8e8d-067c8b927f12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9658","original_object":"UniProtKB:P08173"}
{"id":"73e5b808-5462-4ca3-b88c-a2d8b3cad1d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94489","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:96d122a5-ab33-4ee6-9d55-a1e2b14f1d44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6059","original_object":"UniProtKB:Q16539"}
{"id":"b09d1389-6897-4274-8a58-6911532d69d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2278","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:470d34f4-b38d-4902-bc79-f0eb5d51e148","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2278","original_object":"UniProtKB:P41587"}
{"id":"01b49ba7-59d0-42c4-b841-c1e5cf4b9215","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:950O97NUPO","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:8e2848dc-5451-4f1d-9a55-7240bde47a4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5614","original_object":"UniProtKB:P29275"}
{"id":"9cd32a50-682a-49c7-9537-0868f5f5be13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:581F7DFA9B","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:9b062431-4c76-41a5-99c0-e4934e2b1a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10058","original_object":"UniProtKB:P34972"}
{"id":"6ee78401-cf4c-4cd9-9e8b-219aa7dd7d27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y333RS1786","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:47e600fe-9f64-481f-8b1b-7f2e853d773c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9824","original_object":"UniProtKB:P21453"}
{"id":"3d819cee-ce95-4262-96ee-0838a6e9c9c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422752","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:75abd60f-0554-462e-9f95-4346cd5ec15e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12993","original_object":"UniProtKB:P17752"}
{"id":"1d4a8a30-5a67-45d7-8c26-7a2fba242a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:01J7526K2Q","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:6462b491-2438-42d1-a60a-d2227907efce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9569","original_object":"UniProtKB:O95977"}
{"id":"cbddcecf-b4a1-40fc-b058-feb4e19af3c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38H2BE6LU4","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:efc054ee-53f4-4b6d-b039-86ceda6d056f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12956","original_object":"UniProtKB:P33535"}
{"id":"6391e7d8-03af-434f-b17e-3cf778f97789","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:0cf440d7-8b4e-4e06-92ea-2f0e729f2b7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P07947"}
{"id":"f71cabd1-53e4-42f4-aa23-def5165477c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16325","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:7413f348-5506-485a-91a9-31639afa611e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:611","original_object":"UniProtKB:O75469"}
{"id":"63567de2-ed15-4055-b690-650f8356469e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11185529","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:563baadd-422a-4edc-9ab2-9c6d7217f052","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7772","original_object":"UniProtKB:P48039"}
{"id":"06e1f950-a2a2-459e-ad5f-ec9beca5a7b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3666C56BBU","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:09d17ed7-6fcd-46bb-8fa0-fcf342f6728d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6979","original_object":"UniProtKB:P49768"}
{"id":"0caa14ea-95fc-445c-9de3-f7df41f2082c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035862","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:9db46bd2-1b24-4c4e-8071-43e8d5e74bbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2490","original_object":"UniProtKB:O35433"}
{"id":"bb8b54ed-0fb8-4352-b90c-fd8fa09e761e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15552","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:c51fdbf3-f6d8-4f45-95b3-5b1321412572","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1915","original_object":"UniProtKB:P34995"}
{"id":"89108903-586d-498e-b542-bd94fe52b398","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:6ca2c466-6a2d-4ab4-932a-f871f42dbad7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:Q969S8"}
{"id":"cf9c26dd-8526-42e4-b4f1-61be6a35e046","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71202307","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:e1e89011-8f1e-4379-9840-0590b01476fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7852","original_object":"UniProtKB:P56817"}
{"id":"1f12db34-36e1-4b93-b0c6-28ce86430acf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:95882507","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:26579a21-f030-4b98-8689-dd9d287b42db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9566","original_object":"UniProtKB:Q96LB1"}
{"id":"abd2160f-cb37-443a-88e4-1d16f389c9da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:fc44da5c-d55e-4d70-a495-2f38c648520d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P41595"}
{"id":"d49fcb8a-4bd4-4afb-8ed6-79a06e7ef164","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163827431","predicate":"biolink:affects","object":"NCBIGene:2034","sources":[{"id":"urn:uuid:ea966312-b85a-42b3-9e31-d4ae0c92ab44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13702","original_object":"UniProtKB:Q99814"}
{"id":"37d154cb-f6f1-4daa-aa08-b3a09d950e61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:c9c4c89c-8945-4bc5-8d95-90670d0de9d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:P36897"}
{"id":"a98f7a69-8281-47a0-ba71-b18c6588330e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6172","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:41dfbfc6-9fb0-4fba-b21e-913f0779642f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6172","original_object":"UniProtKB:P30550"}
{"id":"135b7365-ed2c-4040-badc-ada3844d94be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422743","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:acc22b21-8e0a-4773-a9b6-9ff1aa3bf9c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12931","original_object":"UniProtKB:P01116"}
{"id":"328ed9b6-be85-4688-9347-6e1f439379fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8RW88Y506K","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:8b225e93-9868-4468-8eb5-368e4c826caa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10199","original_object":"UniProtKB:P13569"}
{"id":"ebb83d6e-556e-403c-8a69-a607ed30f84d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:731cc335-5d1f-4d28-9f60-d44b3f58003c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9Y210"}
{"id":"0510ac0e-33f4-4596-9ff6-23dec14e13eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9RL37ZZ665","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:1bb26547-58dc-4240-9322-24b5119eba62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7816","original_object":"UniProtKB:P00533"}
{"id":"7c58f29b-4b6b-4ff0-be24-2b0a4da9a36f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13775","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:48f12ea7-5c99-45fe-ba5f-3fe83c04b29d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13775","original_object":"UniProtKB:P22303"}
{"id":"339ba021-9ed6-4c26-819a-16b1b0790e7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49871766","predicate":"biolink:affects","object":"NCBIGene:12209","sources":[{"id":"urn:uuid:c9fafa64-51d5-4933-91a0-069cc7b9387e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6170","original_object":"UniProtKB:O54798"}
{"id":"6ec77b14-b65d-4183-9640-f8672d7ade88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124959","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:b6348607-1fe6-4821-8a67-50f80954b591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11467","original_object":"UniProtKB:P35228"}
{"id":"87701439-011b-4957-b45a-2097db914384","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311129","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:29538c25-8253-40e6-96ef-1f3c9e9216c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3880","original_object":"UniProtKB:P21452"}
{"id":"664ace4e-4751-446a-ba21-88661e7c88cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5441","predicate":"biolink:affects","object":"NCBIGene:83535","sources":[{"id":"urn:uuid:c23c08da-169e-43c7-b0b7-e030ac44ed98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2414","original_object":"UniProtKB:P70673"}
{"id":"b0f7f426-13c3-4ca0-8032-a66c87d3068d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133823","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:0059eaad-139b-4203-b539-5488d84f9fc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3592","original_object":"UniProtKB:O08726"}
{"id":"c5989abd-a673-4fbd-b99f-dd79e323741e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6438","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:239b4022-ebd4-4cb6-87cc-1178404d1299","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:570","original_object":"UniProtKB:P07550"}
{"id":"e5f58e66-d708-40f5-af74-c46e0b9878ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:a8ae3044-b530-4065-b7ea-724e51c63e77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:P48050"}
{"id":"ef4c9eb8-dbe3-4329-a38f-917d3df5f144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67041274","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:6beff4fe-565d-43b4-b1ca-0ac5b382eddd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9325","original_object":"UniProtKB:P04150"}
{"id":"00d1f6f5-c800-469d-aa59-12112b2422be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10878016","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:466654ba-6acb-4918-a33e-a20c1bca9f0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6473","original_object":"UniProtKB:O75762"}
{"id":"ab1fab5f-769f-4f8c-a32a-0c2cbfcb949c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:147075611","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:d39a9698-2f49-4ca2-b5ad-023320b6a3b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12643","original_object":"UniProtKB:P35498"}
{"id":"09c837c1-29c2-409d-b3bc-7beda98797eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:7dc2986a-cbb8-46bb-b817-2b43c6544f2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1052","original_object":"UniProtKB:O14842"}
{"id":"16efa199-ef57-48b0-add9-5370ed672435","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76274","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:a174cd68-0676-403e-8e52-00e7b2f242ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10240","original_object":"UniProtKB:P35354"}
{"id":"b9260c7b-fd29-4521-a331-d3bf4d4bc096","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44377139","predicate":"biolink:affects","object":"NCBIGene:1357","sources":[{"id":"urn:uuid:1c5d4af2-6815-42da-8dfb-538669f0baae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8627","original_object":"UniProtKB:P15085"}
{"id":"0f9a32d0-70a0-4829-90ea-3a784f931eb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42142","predicate":"biolink:affects","object":"NCBIGene:5327","sources":[{"id":"urn:uuid:a51d3232-a955-4d27-9a1e-52ecfc8d5572","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8760","original_object":"UniProtKB:P00750"}
{"id":"053686b9-2d1f-43e5-998f-a70a08aabed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:6a3b6f7e-ca7d-416d-87b2-771648eeb542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q9HCF6"}
{"id":"e6497bff-420b-463b-9512-c6389ab98378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DRZ23E4F7","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:6b49f0f3-e92d-498b-acfa-972cc48314fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5619","original_object":"UniProtKB:P0DMS8"}
{"id":"dee28fe7-e8b8-496f-9ac5-319d6e3e5251","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67271","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:ecdfb264-6eea-40ba-be3a-3f00b4709f95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7945","original_object":"UniProtKB:Q9Y243"}
{"id":"7921faae-5a78-4d74-afce-e2eff7b73846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133792","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:838e2b25-8cf7-4382-bda7-283ddcd52d79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:689","original_object":"UniProtKB:P30988"}
{"id":"2dcb2eba-4a78-43f6-ae23-f2b30e5e5509","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63115","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:21863f67-4a6b-4779-b151-cc76b28700e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2407","original_object":"UniProtKB:Q923J1"}
{"id":"c1efa9b6-b12e-45fd-ba86-ac7f6ea5ea2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156016579","predicate":"biolink:affects","object":"NCBIGene:8824","sources":[{"id":"urn:uuid:3564b8f2-0473-4323-9b0f-54097c023ebf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13569","original_object":"UniProtKB:O00748"}
{"id":"b0dc2464-91aa-4daa-8188-50805c29b089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5147","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:9b002c3d-5d0d-44b2-984b-461b14287b42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3465","original_object":"UniProtKB:P07550"}
{"id":"bb776701-2097-4cd7-ae97-5510a9a93244","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12605","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:6e70e0ca-191a-4c8f-ae6e-f8b4a1632a0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12605","original_object":"UniProtKB:O43614"}
{"id":"adeb54a6-a6d4-4d48-b504-f7c5e82fd09a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230819","predicate":"biolink:affects","object":"NCBIGene:6511","sources":[{"id":"urn:uuid:bc8f39ab-d16b-49ac-a576-94303800888f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4631","original_object":"UniProtKB:P48664"}
{"id":"b96c1fd8-fa16-4e8b-bfa3-f21d3e13b93e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31485","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:e2f7dd2e-16d6-4199-92e5-2ea5aa4492d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7474","original_object":"UniProtKB:P04150"}
{"id":"23e6451a-b571-489c-bf66-1793e4a4b1a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3562","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:fe2cea9e-cc97-4b8f-bb3f-7ac2daadaa1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3562","original_object":"UniProtKB:P32239"}
{"id":"93ba02e0-1825-4604-a142-e43bdbd5d8ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:c93bb5c6-c9e9-4be5-a950-1ac758bcbb54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P18089"}
{"id":"53fe0143-b149-457b-9932-2400c9b9b5a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:2c92f703-88bc-492a-9591-5541c7ca98fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:Q91ZY1"}
{"id":"b6e11e56-4817-49d7-8b86-95d2e850aaa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146662729","predicate":"biolink:affects","object":"NCBIGene:51755","sources":[{"id":"urn:uuid:5d0efcc1-57cf-4cc6-a037-3bb83181c6d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11841","original_object":"UniProtKB:Q9NYV4"}
{"id":"96b4a0fa-cb8a-4c44-8bf5-0755b227d311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:0910c183-7956-4170-a5a6-15e3c14cfaff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P0DMS8"}
{"id":"57562469-799d-4860-b9bf-2a1119171331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9871234","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:8d354fee-dc6f-4b4b-8e21-72f7ee2aca31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5778","original_object":"UniProtKB:P21452"}
{"id":"87a4030d-84a4-4ba1-bb1d-74f1ccc5cd70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10568125","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:49972ef3-1266-43ce-b5bd-b26184e5b479","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:399","original_object":"UniProtKB:P29274"}
{"id":"a378f881-7854-4919-82b2-b465875c2ad7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63053","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:cebf650b-806e-48c4-87b4-deee6cc78ee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10356","original_object":"UniProtKB:Q99835"}
{"id":"ea56fccc-5828-4eb2-b989-5887b2e0f980","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6EM57086EA","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:7c4fe28c-b72f-434a-afb1-3e4926743bd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7947","original_object":"UniProtKB:P53350"}
{"id":"e8ad1920-7553-496e-8fea-4b29edf35032","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:2042","sources":[{"id":"urn:uuid:95bc963e-b7e3-49a4-b58f-bab49a8be208","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:P29320"}
{"id":"3723914a-610d-45da-95bc-786ae33b1db8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:4df0094e-ea95-4f99-af34-ec15451f3ca8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P16234"}
{"id":"0597d916-61b8-40bd-984d-78ab3c007d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27607","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:7a9c8353-ea4d-4e53-9109-600d42cf2aba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2499","original_object":"UniProtKB:O75762"}
{"id":"68abfd68-3c3f-402b-ba3b-f5b36d2997f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119086","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:213cdaa2-6346-4080-bae1-d0dd7fb56453","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3453","original_object":"UniProtKB:P06401"}
{"id":"844b853a-51a0-4e8e-8d9e-79b30949b2ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:4578d94d-4159-4c49-bccd-e920bc4a4bf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P61169"}
{"id":"475a4321-57ff-4412-a268-6826b3055b4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:25CG88L0BB","predicate":"biolink:affects","object":"NCBIGene:1075","sources":[{"id":"urn:uuid:452e4067-f66d-4652-8470-209715ca0c7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9412","original_object":"UniProtKB:P53634"}
{"id":"4088b6be-33af-4732-af64-52819555813c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:364","sources":[{"id":"urn:uuid:9540d16b-974a-4d88-8682-d336bf918cec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:O14520"}
{"id":"c2132d36-faed-4625-93f5-04dfdd4024e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:35f483af-3866-4666-a4d2-9651aa9749ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q9BY41"}
{"id":"13e5c457-1f27-4368-9572-e64b433d4c8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71113742","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:1eff8e5f-8fb9-4d74-957a-a6abbab129f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11886","original_object":"UniProtKB:P43405"}
{"id":"3cdf6431-348f-4dff-800b-e8403ffe0ff8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162749590","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:404c0960-7139-4464-b758-f3f1a2656caa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13338","original_object":"UniProtKB:Q96P20"}
{"id":"b026d50b-ef2d-4ab7-bf49-86dbd662f4a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76607","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:a62a66a8-87df-47cb-8911-27d3de903fb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7352","original_object":"UniProtKB:P25101"}
{"id":"bd4c0eca-d9bd-4a27-a580-70df4727c3aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GE2T1418SV","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:be92ae48-9406-485a-9bf8-10d93944b024","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7354","original_object":"UniProtKB:P11229"}
{"id":"45c3931a-88dd-4f6a-ac6a-566542ddfe25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24748735","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:ad9ab77f-fec8-45c3-92f6-2bb7dd4f648b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6119","original_object":"UniProtKB:O08726"}
{"id":"544bb150-3700-4bfd-b087-34c196773b15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93066","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:77c0edf8-d577-45d1-831d-152d61e623d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5764","original_object":"UniProtKB:P29371"}
{"id":"9f89c760-f34c-4e3c-83fc-a65d101905e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8273","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:005501bd-8c40-4816-ba9a-bb9dc97b6e6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7003","original_object":"UniProtKB:Q09472"}
{"id":"cbc34ba2-5eaa-4e1f-8122-17b4fd4e6c90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117972004","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:6ab140c1-a8a5-4fa9-83ca-4b698d3e0bc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12098","original_object":"UniProtKB:P21453"}
{"id":"5f2d275b-6c3b-4f09-a3d6-6dd7cd8b91d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2187","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:d3e3d813-85c4-4dcf-84ce-41a1a89736d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2187","original_object":"UniProtKB:P30559"}
{"id":"0ff190f3-ba79-475c-af22-1b63d4cf8d90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131173","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:794da4aa-8e44-4d09-89d9-4c8f2c870446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8069","original_object":"UniProtKB:P09619"}
{"id":"e632d2c0-68b7-4278-b658-52312c646dcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WBH8AY6ENB","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:7e2b8010-efc5-4bcf-9e59-26a90ea74b75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10313","original_object":"UniProtKB:P11802"}
{"id":"e1884166-e630-4036-98c3-5650a89c3917","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:2e38a3ed-e553-4d71-b879-b8b559f071ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P12931"}
{"id":"233a5cbb-9124-4ba8-a98f-c892136b92be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129234005","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:3710912a-6810-4313-88c7-83928b7a5b47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12239","original_object":"UniProtKB:Q06187"}
{"id":"7f71be37-6c7f-4b35-9069-53a119d63e88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66901","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:fc38d8a2-c554-4b04-8e62-2c51fa73089d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4342","original_object":"UniProtKB:P13569"}
{"id":"25594a50-c054-4393-af3b-24627337ae19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841284","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:dec68e53-31f0-4f86-a9fe-a67700eb991d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:423","original_object":"UniProtKB:P30543"}
{"id":"00035b82-a2d5-4630-b4b6-544f2743dac6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4GF4A623RF","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:c4750ca7-6cd6-4041-b054-4b6810859bcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8051","original_object":"UniProtKB:P24941"}
{"id":"6b377aca-58d8-4dc1-9a4a-03cc2d23573a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194294","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:f3be8bb8-8859-4ef3-881b-876f669335e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13538","original_object":"UniProtKB:P33535"}
{"id":"e4c88f55-36a4-4fab-81db-9529fcec1ae2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17303","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:019011ed-3de9-423c-8d10-48da7676887e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1627","original_object":"UniProtKB:P41143"}
{"id":"9b7b4943-e37d-416c-8027-7136b4ee7460","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11597537","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:4fc29317-a3b0-480f-9a0d-06f58be2f0c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9836","original_object":"UniProtKB:P45984"}
{"id":"014ad7a0-a127-4ecb-95a2-2f59b78b227d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9949648","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:91058d9e-c878-45a7-9693-c79eced71800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2600","original_object":"UniProtKB:P56696"}
{"id":"ef18f6eb-6e6c-4ca1-a995-a21b64a63114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993666","predicate":"biolink:affects","object":"NCBIGene:2289","sources":[{"id":"urn:uuid:aeb76880-2227-4e14-ae97-9ce34ed22f7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12610","original_object":"UniProtKB:Q13451"}
{"id":"0eb7a7a7-4f30-41f1-a670-d67e8671b17d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194387","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:f6d54cf4-c314-46fb-8ba0-61951e6d6215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1393","original_object":"UniProtKB:O00222"}
{"id":"922d8e97-037b-4aa7-9e24-18bb5ec011c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311344","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:1296e6b4-a33b-4725-8be5-eca93f69198f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3335","original_object":"UniProtKB:P31421"}
{"id":"b2083ba8-391e-4c76-8497-0c5c542bf8ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18300","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:66d7a0f6-effa-4974-8787-7a09026aeae9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9630","original_object":"UniProtKB:Q9BXA5"}
{"id":"cafa3034-efd1-4841-861b-774fb3e69825","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P9UTN18JVV","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:59d0af36-ed4e-44f5-9876-f404cda05b4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2670","original_object":"UniProtKB:Q07869"}
{"id":"6adafff2-ebf5-4a23-a22b-2dd86408d97a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1810","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:8a92a8aa-2ac6-4f64-89e8-f93f1629f956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1810","original_object":"UniProtKB:Q03431"}
{"id":"78a595a9-a0dc-4e39-840a-305a1bbbb593","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T74V9O0Y2W","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:037da275-5958-47cc-81ec-b544fbe469db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4311","original_object":"UniProtKB:Q8NER1"}
{"id":"7ced1b2a-eac7-452c-a1ce-6e54b7438cda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3743","sources":[{"id":"urn:uuid:8da70227-08fb-4fbe-9582-aeae4c469f80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q96RP8"}
{"id":"9ebdef5d-8e90-4a08-9aa0-7834c06c9eea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13316","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:415c9710-62f7-4156-80bc-f2b0be6be74c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13316","original_object":"UniProtKB:P43219"}
{"id":"501eac72-2212-4440-a68b-fe5579a1edcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94409","predicate":"biolink:affects","object":"NCBIGene:347411","sources":[{"id":"urn:uuid:0ff0f3b8-8b00-432f-b1fa-ad62b8613466","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11303","original_object":"UniProtKB:P0DKB6"}
{"id":"9520c62d-3f38-41df-8338-c97c0a398e51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2952","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:20aa22d0-7ade-49eb-b2f8-3f55d9b90a59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6980","original_object":"UniProtKB:Q01668"}
{"id":"5948a3ca-1e07-4130-8348-47d42c56ce48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DFS3SIU1ME","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:0da4e03b-5639-42df-80b1-6ac78341e182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1374","original_object":"UniProtKB:P31424"}
{"id":"3e47fda5-5885-4b32-be5d-d3563f8d09a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94812","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:008a8fdb-522d-417a-a59c-7a5c89619a7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2691","original_object":"UniProtKB:Q03181"}
{"id":"51efe258-339f-42d7-9807-30cb54e50e3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5000","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:9d3ff36b-edc4-4823-8c22-37b8196c8897","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4613","original_object":"UniProtKB:P17752"}
{"id":"3c217544-5edd-4efb-aada-1c9057a058c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80343","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:5d98edbe-4951-46dc-b2f7-46cdb5a85a28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4971","original_object":"UniProtKB:P08069"}
{"id":"11cba79a-e72f-4a7e-9790-0acbfffdb275","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15794","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:0c21bb49-6356-4e79-9560-d784db0c6869","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13647","original_object":"UniProtKB:O14965"}
{"id":"183f486d-911c-4e42-88e5-fce239897368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10486131","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:ffe0ef7c-f000-4687-94c7-50b272551335","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1621","original_object":"UniProtKB:P35372"}
{"id":"5508499c-2969-440a-8b53-f160a1c8cb48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:766","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:2bdfa4a0-2ae5-4418-9e41-5fc1beb3959b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:766","original_object":"UniProtKB:P51681"}
{"id":"92ee30e9-a486-409f-8d9c-7a6957fd4110","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PP0SHH6V16","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:11551c52-f799-4d22-8611-5617bab3e7e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6744","original_object":"UniProtKB:Q8NBP7"}
{"id":"614e4617-639e-45a9-a27d-933ad51890e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101355","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:9f70162e-0453-4362-8f47-7bcfbb4b4406","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8940","original_object":"UniProtKB:Q13153"}
{"id":"9990c6a5-df8b-4178-a2de-71dec9dca24f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15367","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:0f8dd90a-6188-4079-ae46-24910c43e373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2644","original_object":"UniProtKB:P10826"}
{"id":"bdb4a6e6-b726-4724-b03c-80503da78607","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:d46aa119-6eb6-4829-8999-7ee4a9c8f419","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P32304"}
{"id":"82931d60-26f9-4f4f-bc6b-b6d7cfcb2613","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195559","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:03c32b46-a228-4cb6-9472-685b51c9f7d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7903","original_object":"UniProtKB:P00533"}
{"id":"36fb8312-3cbd-4062-bd13-83a951c46173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:653","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:666c3e79-f3af-40d5-af6f-31bc9c09acd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:653","original_object":"UniProtKB:Q61125"}
{"id":"dd63c3ba-21c9-41c3-b8ee-ff5b2aceaf5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:27334","sources":[{"id":"urn:uuid:790c649c-c9f1-4e5a-baae-374890a253fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:O00398"}
{"id":"457ed301-055d-4381-aabc-b12f5989a415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3994","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:65111e48-d23e-45dc-827e-b2bfc89fd27b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7151","original_object":"UniProtKB:P35367"}
{"id":"e66de1e7-511b-4200-a832-15e367f63b52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129140","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:81862d1b-74fb-480e-ab30-d4429f67d562","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8583","original_object":"UniProtKB:P08912"}
{"id":"46db62a1-4b72-46d5-b727-ab5b4d24b5ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488756","predicate":"biolink:affects","object":"NCBIGene:60432","sources":[{"id":"urn:uuid:218298c1-15bc-4294-8fed-baac34cd0850","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1141","original_object":"UniProtKB:Q9Z0W0"}
{"id":"07cc9ed2-72d1-4d1d-b348-b57ed18c9898","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0TJ631J0KP","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:885453ce-c94c-4f76-ac8a-8346dd5e947e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8179","original_object":"UniProtKB:Q16539"}
{"id":"b63dda58-ca7e-4005-a3de-15caa1c930e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16053","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:2a1759de-1aa6-491b-86d4-7de48deb5ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2472","original_object":"UniProtKB:Q8R4D5"}
{"id":"3755102b-b3e9-4081-a408-fe93224d00e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:152231544","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:ff17c270-ded6-4d2d-9583-b32188f68ef1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13221","original_object":"UniProtKB:P23458"}
{"id":"3a4b0586-908d-4eea-898c-97f3ddc56ab5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9908595","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:ff21ea64-279b-4cf6-8972-3426ae673ab4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1879","original_object":"UniProtKB:Q13258"}
{"id":"d848df38-37f7-41db-bb17-d376b228917d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17115","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:98d06961-f00f-4aba-adf6-49a9e411df29","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4171","original_object":"UniProtKB:Q13224"}
{"id":"b2f19b57-b570-4334-bec4-1ef2429a9cf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1487U1Q3IQ","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:0f6fde3e-09c3-4a5e-848b-472b24a37e88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10464","original_object":"UniProtKB:Q06187"}
{"id":"328100d8-7db5-4d1b-a85d-e92da8ef7632","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80343","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:17fbb933-dbae-427a-9f8d-088bab49e803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4971","original_object":"UniProtKB:P06213"}
{"id":"aeef8fdd-0358-4438-9948-e01e73c2b07d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755251","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:22be23ed-5467-4466-9c48-3db11685969c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6983","original_object":"UniProtKB:P61793"}
{"id":"b5cba239-1520-493d-b62a-501cecce29d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11452311","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:0e195289-f4c8-4e5d-8306-d1ecb53b4e4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9103","original_object":"UniProtKB:Q9Y5N1"}
{"id":"a006c08d-8196-4786-9eb5-ab41a9c70e04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0I32BCL40Z","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:83d4725e-bd20-4be0-8295-04a4872df3c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3528","original_object":"UniProtKB:P21451"}
{"id":"eb8a5e25-f40f-4619-b28e-b54c231e984d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135351","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:afc4a434-7a21-49bf-a431-56a08421fc86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:941","original_object":"UniProtKB:P21918"}
{"id":"8fe2e0f1-a204-46b4-b833-ae81a21f0206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817427","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:9ebd1a16-5af3-45ef-b2bd-221c58f4919c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1788","original_object":"UniProtKB:Q03431"}
{"id":"e2bb4233-3485-4f02-9ccb-9fd34842ad49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6839","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:0583ff2a-d40b-477c-ab5c-cea27a6ddd57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:483","original_object":"UniProtKB:P35348"}
{"id":"6498bf09-d8be-42e5-8c42-40e346223be4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:31SPV65I6F","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:067e220f-3eff-467d-87c7-4a815b9b8a8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:389","original_object":"UniProtKB:P30542"}
{"id":"dac1cf72-1275-4ab4-9d08-ca5cfc89c674","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3900","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:20c4ce8b-8151-4f77-9f14-84d8cebdc44b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3900","original_object":"UniProtKB:O43603"}
{"id":"eeaa6a02-66bd-4e31-aeae-2835537c8343","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24893979","predicate":"biolink:affects","object":"UniProtKB:O54898","sources":[{"id":"urn:uuid:25c95c43-34d5-4b2d-b497-af1a1f1bc10e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7723","original_object":"UniProtKB:O54898"}
{"id":"926c71ec-b61a-46b5-ba00-17b6212da004","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553171","predicate":"biolink:affects","object":"NCBIGene:8322","sources":[{"id":"urn:uuid:06debe37-0287-4935-85f6-e198c1dff1ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10321","original_object":"UniProtKB:Q9ULV1"}
{"id":"043406a2-ea6c-4b91-860f-f101b0370698","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167659","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:0185faf1-851c-48ec-896b-163d1c8a8267","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9909","original_object":"UniProtKB:Q02750"}
{"id":"07231661-4be3-42ff-ba1a-8121cdddb67a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7W8X3AXG75","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:12ec3652-9dfe-462f-8c0a-5d1f78a5dbc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2046","original_object":"UniProtKB:P30874"}
{"id":"27cd18a4-871a-4371-980c-585737ae503b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864283","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:b70e1974-d36a-4bdf-adbe-de3960a86a1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8209","original_object":"UniProtKB:Q9NRM7"}
{"id":"ccf995d4-d470-43ed-b383-b597a4f668f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O14CWE893Z","predicate":"biolink:affects","object":"NCBIGene:7941","sources":[{"id":"urn:uuid:c9865668-9949-449b-af60-3699110c0075","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7376","original_object":"UniProtKB:Q13093"}
{"id":"358f5779-6833-40f0-90df-0cdd36b8c7e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:140741","sources":[{"id":"urn:uuid:feecf897-6c9e-42cc-862d-4320d06b651e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q6YNI2"}
{"id":"feef0e97-cde2-48bf-92da-f1ade6f9f0bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64191","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:a194edca-32cb-45bf-9100-d198585058f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:44","original_object":"UniProtKB:P61169"}
{"id":"489e11b2-b4f6-4181-b8e8-77fcd2f11713","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL85606","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:e4d8f89a-765d-4d83-b213-cf41d37ff85f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:143","original_object":"UniProtKB:P28221"}
{"id":"4c25f2e0-dc34-4834-b96a-f5e89dd66041","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:6444ea7c-ed4d-4ab1-8e9f-ba8e56e4592b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P24046"}
{"id":"bb268c0c-996a-47ce-afc9-dd9cb4cfb1a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7458","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:43a28efc-bfaa-4443-a1b5-e3937ffd0ae0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1629","original_object":"UniProtKB:P41145"}
{"id":"e116c6ff-24aa-4100-b998-be5cc35a2c5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54764565","predicate":"biolink:affects","object":"NCBIGene:8999","sources":[{"id":"urn:uuid:29811c28-49dd-4d6e-be53-9a838a37ebbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8106","original_object":"UniProtKB:Q92772"}
{"id":"109ace72-bdb6-4ad3-bfe2-c363e6631d1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65349","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:c6d86d46-1829-4bee-b836-2817d87334c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7445","original_object":"UniProtKB:P07550"}
{"id":"e880fd2a-3bf8-4cb9-a914-f7f3464c1872","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:349149","sources":[{"id":"urn:uuid:69293a5e-f908-4ddb-b967-45987260b54b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q8NFK1"}
{"id":"da0f5fd2-1a8c-4174-90ea-5dbee7b4d8ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2034","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:e4948b4a-4326-4a8e-8872-d3f884e2a33a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2034","original_object":"UniProtKB:P30874"}
{"id":"026909d7-9531-4d1d-808f-cc46fbdea7dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:fc5d7f73-2abf-44cf-a97d-fe08526c7e6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P35368"}
{"id":"4c22b814-29f3-4a86-b888-8fe3ecd06add","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1186073","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:5e52db21-849b-47dc-afc6-24838ff7e069","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6716","original_object":"UniProtKB:P48449"}
{"id":"fc734ebc-afed-460f-a489-e37a8810f590","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91936970","predicate":"biolink:affects","object":"NCBIGene:5609","sources":[{"id":"urn:uuid:33df9844-6573-4191-b5c1-50d2c03a6be5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9989","original_object":"UniProtKB:O14733"}
{"id":"f0cf123d-7c4a-4547-ba5e-71e4b66c291c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231087","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:57db7b6d-6cc8-48af-9a51-47cf0d36fc8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9626","original_object":"UniProtKB:P11802"}
{"id":"399ead6a-556c-49f9-8ad8-d70211bdaae5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2613","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:efa132f2-05cb-43f2-a02e-cd5ff4ce6936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2613","original_object":"UniProtKB:Q14524"}
{"id":"b3cd7e1d-3081-4c24-8070-210eac18b0ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28121","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:2f17a026-22a0-49f8-abf0-2f53078bce61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9352","original_object":"UniProtKB:Q9Y463"}
{"id":"12aff255-3477-43d3-b906-54ceade33f2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59004159","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:fd9e0248-5475-4389-b575-22cc53be34e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7042","original_object":"UniProtKB:P04201"}
{"id":"25d4937f-f679-4462-99e5-3178d424b2d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25053598","predicate":"biolink:affects","object":"NCBIGene:10125","sources":[{"id":"urn:uuid:fc13e144-254b-4099-8cd9-f0117255a77a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10066","original_object":"UniProtKB:O95267"}
{"id":"396fb09d-117c-4a3d-b492-f8f657759311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75722","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:2ce275d0-42ed-4eb8-b48e-3162c234ac49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8286","original_object":"UniProtKB:P35372"}
{"id":"78713855-6779-476f-a1e9-7edc3d258fe4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27641","predicate":"biolink:affects","object":"NCBIGene:2280","sources":[{"id":"urn:uuid:3ad896fa-6409-4dfa-b7f8-9b88841bbcfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5433","original_object":"UniProtKB:P62942"}
{"id":"f5f58b37-6280-497b-b371-da68b20ffdd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:192d3f11-bbc4-4011-a30d-8ae07818ea47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q14643"}
{"id":"b54ba787-11bc-43b1-aa0b-cae4284c2069","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59547990","predicate":"biolink:affects","object":"NCBIGene:80228","sources":[{"id":"urn:uuid:b182e565-4b95-46f0-81ea-9af7c329ac13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10088","original_object":"UniProtKB:Q96SN7"}
{"id":"a44129df-e156-4183-92a8-a5a33ea0b3ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3103","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:6ab08336-c876-4942-bbd6-a50de744d386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2366","original_object":"UniProtKB:P46098"}
{"id":"96baf29d-6b2b-417e-bc14-9c4465ac58c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44365677","predicate":"biolink:affects","object":"NCBIGene:49","sources":[{"id":"urn:uuid:9438214b-9ba3-413d-9e4e-114acea9d238","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8559","original_object":"UniProtKB:P10323"}
{"id":"6a989986-eb09-4ce7-896b-f779fcced403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64131","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:426393c7-4ea3-4ef6-841e-721f4144d2ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:73","original_object":"UniProtKB:P35368"}
{"id":"27d50a94-f4e1-46d1-9e51-ed5f24b3639e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2153","predicate":"biolink:affects","object":"NCBIGene:57305","sources":[{"id":"urn:uuid:1c4513c0-216d-439e-baca-607236d53cdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2153","original_object":"UniProtKB:P49684"}
{"id":"1c30aa86-029b-4c1a-b28e-10257ce1f01d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2726776","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:4b2d3104-423c-49e1-a9f6-252bcaa92088","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13051","original_object":"UniProtKB:P32249"}
{"id":"71187580-3610-43a6-adb7-4339c61d005d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4fe98a8d-72d1-4d73-9d37-9253227f3c51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P28223"}
{"id":"f4133a9e-70b6-4bf7-a762-8dd6587845d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125525","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:c3ee1eb0-376c-4390-a387-f7c2f8786b69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1238","original_object":"UniProtKB:Q9Y5N1"}
{"id":"ec8321ca-fb3d-4cf1-bbb7-b45b63cbe26a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8EJD945ABL","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:5e10151c-1808-4287-9a55-d64bdbe5fd96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6675","original_object":"UniProtKB:P35462"}
{"id":"137929e4-9b49-4027-970a-03af62db0805","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8JJC99KHGL","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:f68401e2-f676-4c5b-93e7-8e2a4d539d0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11118","original_object":"UniProtKB:Q9UBN7"}
{"id":"bc95ab60-8329-4125-9844-3ca55ae7f6e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871638","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:761eef4c-98a5-4093-ba5d-eef1f5379c7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8206","original_object":"UniProtKB:Q9UM73"}
{"id":"8c86e397-304e-4a74-8789-198e129c400f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659802","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:1c715987-e833-454a-9bfc-5c93d2896f3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6348","original_object":"UniProtKB:Q13255"}
{"id":"8b6dff3e-f655-4393-9763-5bd66335f5f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL69234","predicate":"biolink:affects","object":"UniProtKB:Q9JJX6","sources":[{"id":"urn:uuid:cb330a2f-243a-4269-9bca-3ab4bd07eff5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1725","original_object":"UniProtKB:Q9JJX6"}
{"id":"57a53aab-38e6-4832-9d42-851ebb915d28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827358","predicate":"biolink:affects","object":"NCBIGene:54496","sources":[{"id":"urn:uuid:713ff774-ec80-42fb-88b9-945b949e6cf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8395","original_object":"UniProtKB:Q9NVM4"}
{"id":"2744c843-6ff2-40ee-a4e5-27847a78ab01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92683","predicate":"biolink:affects","object":"NCBIGene:9622","sources":[{"id":"urn:uuid:ad8b2fdb-f39a-407f-98d4-ade5bb2bd3e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8874","original_object":"UniProtKB:Q9Y5K2"}
{"id":"dc38093d-c06f-4a4b-bc40-70ee45ce7bd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56597775","predicate":"biolink:affects","object":"NCBIGene:11213","sources":[{"id":"urn:uuid:7cf54499-684b-4f87-a103-d6947fad7336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8213","original_object":"UniProtKB:Q9Y616"}
{"id":"d89dca21-c04a-4085-a239-a905784bc762","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9951490","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:b647db07-ed0f-4991-914e-325b0035f96a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6006","original_object":"UniProtKB:Q02750"}
{"id":"953d0608-475d-4e22-af06-ffd496e38829","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:9ebf779a-d4e7-4243-ba75-9a791024e833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:P23975"}
{"id":"76a59009-055c-44d4-b42f-5d3c1dddc517","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1328","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:6ac0f611-5718-4b37-a599-31fcd14ea6fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1328","original_object":"UniProtKB:P32245"}
{"id":"63bf0179-ad7e-40c1-97e5-fb1ba9e3bc15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847474","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:d1b4b755-b162-4cdf-b4b1-6e171b5ac468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3184","original_object":"UniProtKB:P14324"}
{"id":"6938720a-429e-4d6a-beff-c3dea1472540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11435","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:1673da06-7f0f-465b-88d8-d6abff6a0802","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11435","original_object":"UniProtKB:P32247"}
{"id":"7afb5b61-9a5f-4b3f-9cd7-9b7401353747","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3665","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:42a701b4-e0a9-465a-afff-9b5ffdff6aa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3665","original_object":"UniProtKB:Q96P65"}
{"id":"4788e329-dde1-4706-9fd6-c9f974536c53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156775102","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:a51d9d0c-05d2-41da-a5b5-feddf273a52b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12143","original_object":"UniProtKB:P53350"}
{"id":"725a2e5d-4c83-4aed-a8c9-b02bcaa5da72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:c325d3fb-ba9c-454d-ac2a-b57ddb6f068d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P30530"}
{"id":"6bec789e-a9ce-409c-bcd0-bf0d3fe4bcee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118893637","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:e29f8a09-0fda-46f7-b681-0037b8850a60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13218","original_object":"UniProtKB:P22455"}
{"id":"3159db0c-2833-468c-b4b4-86e39365cbec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"UniProtKB:P30940","sources":[{"id":"urn:uuid:07405201-8744-4a97-9d12-e5be111f3c0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P30940"}
{"id":"d9e4c786-cf71-46c8-ba01-3cc74155d21f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755013","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:e7c6f6b9-fa35-4fbf-a4d7-4fbd31dbdbf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1838","original_object":"UniProtKB:Q62035"}
{"id":"85a5c183-ee10-4c6a-979c-9f3a6f04bad4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31623","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:c4177d5f-43c6-4fc7-b6d8-7de1347770a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7077","original_object":"UniProtKB:P04150"}
{"id":"cb2eff84-bd7c-45ed-a921-841502ce54ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947515","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:04ff7849-e460-4b7d-942b-69d888c68615","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9916","original_object":"UniProtKB:O00329"}
{"id":"42ccf768-9964-42a4-99fa-beded98bd901","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:704fddbf-1121-4fbb-b809-afaef476e942","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P28223"}
{"id":"8f19cc28-a96d-4551-993a-a5f3d2620ee1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132369","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:03db3740-b3ee-4131-a98c-ac0994232d2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2280","original_object":"UniProtKB:P35000"}
{"id":"e4f53bf9-eaf4-430d-ba17-98ac03c9c2aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166161683","predicate":"biolink:affects","object":"NCBIGene:8192","sources":[{"id":"urn:uuid:ba5316d1-a321-4772-a4ad-99c188f7a515","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13172","original_object":"UniProtKB:Q16740"}
{"id":"1fec996d-70af-4522-8796-75030e149eae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136416849","predicate":"biolink:affects","object":"NCBIGene:10724","sources":[{"id":"urn:uuid:5cd3ff74-44ed-49db-b6b0-6f45cc295cec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10508","original_object":"UniProtKB:O60502"}
{"id":"ac080f85-0551-45b7-9557-7e27cfdfe505","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13352","predicate":"biolink:affects","object":"NCBIGene:18129","sources":[{"id":"urn:uuid:f4a4f52a-0566-46bc-80fc-cbbb13b9e035","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13352","original_object":"UniProtKB:O35516"}
{"id":"65b060d0-c70c-46a2-a694-756e09845ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11624601","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:b9d7a45d-548f-4402-8113-d4f05b3328a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5998","original_object":"UniProtKB:P53779"}
{"id":"8eced1c5-0284-4c8e-bb2d-3b0e94090824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TQ25KB5NW9","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:c1488f8a-8953-4409-bf5d-cd460e365b36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3372","original_object":"UniProtKB:Q14416"}
{"id":"a0464a41-6a13-401a-978a-b32ff8c60140","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132509","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:c41595ab-d3dc-4486-aeda-98038f624a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9392","original_object":"UniProtKB:Q5S007"}
{"id":"62328939-4199-4fd3-8701-a9900b8c9ab8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10164","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:93c47846-f2f7-4e77-8ff9-e1690c1319a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10164","original_object":"UniProtKB:P32246"}
{"id":"e84dab01-864a-439d-9e62-6fc9d1d7cbb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449532","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:4a26ec01-96e9-4a49-8d1b-c109b8c72a93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2695","original_object":"UniProtKB:P37231"}
{"id":"418bf23a-5301-4429-b533-1784736ead82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448902","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:be55cbb7-c502-40fa-9659-5d7a40af14b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12485","original_object":"UniProtKB:P21802"}
{"id":"18794f0f-41cd-4cd1-800f-2ed247f74e81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146361282","predicate":"biolink:affects","object":"NCBIGene:4158","sources":[{"id":"urn:uuid:39ee3d6f-5098-48c0-8040-9e7ffac2355f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13339","original_object":"UniProtKB:Q01718"}
{"id":"a563720d-3b66-47e4-b85b-be215cd2a76c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78432","predicate":"biolink:affects","object":"NCBIGene:83942","sources":[{"id":"urn:uuid:cb25f68f-9fd3-4a5b-8c72-0cca1b9890de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7397","original_object":"UniProtKB:Q9BXA7"}
{"id":"334e88a2-4132-408b-b49e-65422c20998c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10710647","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:ee4e9fb0-cc89-4ff8-9cca-cda355abc333","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:395","original_object":"UniProtKB:P29274"}
{"id":"32ba6173-7c39-4764-b0a4-7725d653fb74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N03P021J8","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:260d4d1c-0de8-4efb-9cb2-f8e301c9f640","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7954","original_object":"UniProtKB:P29597"}
{"id":"28f381b1-7d66-472f-9f03-7862b0c1fcae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56597938","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:5cf2f1c3-d662-46cd-be6e-f5a3f1ff4196","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7651","original_object":"UniProtKB:P14416"}
{"id":"92f128b3-511b-4f45-8931-eab394fd58e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:ce4aa387-a545-482c-89dc-925e5b53d8ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:P78348"}
{"id":"31692644-abdb-46e3-bd92-713b9016f1c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3699","predicate":"biolink:affects","object":"NCBIGene:59352","sources":[{"id":"urn:uuid:01ed28be-8487-499a-b64b-4e460efd10b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3699","original_object":"UniProtKB:Q9HBX8"}
{"id":"19547bef-4c17-4256-b1bb-cee99a63c8a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42628843","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:13703b77-10d1-4a6b-92c0-a3289a1b8fe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9815","original_object":"UniProtKB:P12931"}
{"id":"8292e44d-c268-4455-9eee-ed40aaaa7edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:d7a66c59-5306-4224-873f-7ab0d58966aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P31391"}
{"id":"c2c78ed9-695e-4761-b220-f500be4b962c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2533","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:b39b6065-cd25-4c14-8051-c9eab3bc3283","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2533","original_object":"UniProtKB:Q02294"}
{"id":"19503b13-5cee-4d1c-b667-74be4fc3f277","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91801116","predicate":"biolink:affects","object":"NCBIGene:3416","sources":[{"id":"urn:uuid:b026ace2-a63c-445d-b2ee-ec9fc9ebd0b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8596","original_object":"UniProtKB:P14735"}
{"id":"a8fe6702-2e35-4f8d-94e5-324dd277c53b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134724","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:44ee5b49-94b1-41fd-8092-dc05b99947dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9394","original_object":"UniProtKB:P31639"}
{"id":"a723d3b9-bd53-416e-9626-6b1a32f53469","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:8491","sources":[{"id":"urn:uuid:4d1000bd-d801-48a0-962e-6f7bdd0550e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:Q8IVH8"}
{"id":"f04415b9-6869-45a7-86c8-03afd9f2492c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131345","predicate":"biolink:affects","object":"NCBIGene:778","sources":[{"id":"urn:uuid:f7b3ed45-f3a8-4b40-a789-0e506f006ba5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2511","original_object":"UniProtKB:O60840"}
{"id":"870676f5-fcc2-4083-b2c1-b1d87bb91d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34654","predicate":"biolink:affects","object":"NCBIGene:3738","sources":[{"id":"urn:uuid:38025ae0-ca2a-46c7-86e5-dcd7148f366a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2555","original_object":"UniProtKB:P22001"}
{"id":"16106c9d-fa25-444b-96aa-0a7ceb3c0540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136007","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:6ca076d0-f30e-4a87-aadc-a832ffe52e01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7563","original_object":"UniProtKB:P35372"}
{"id":"abeca605-817b-4c84-b54d-57ab6a4c63fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U8C5C9D65S","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:2d32accf-803e-4fd6-a2a2-af831238929e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3953","original_object":"UniProtKB:Q13255"}
{"id":"e6bc918e-cb7d-46f7-898c-ef95dabf2b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911338","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:2f2048ab-1e7f-48fd-8d8e-0e269ddc11cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10437","original_object":"UniProtKB:P31749"}
{"id":"f6482167-9499-4280-82d6-ad354dc1a7d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:117155","sources":[{"id":"urn:uuid:f1fa752e-ef6a-40f8-a22c-769a4170c381","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q96P56"}
{"id":"e0e8a03e-d630-4b82-b447-15963dc79186","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9807431","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:c5fb6940-5021-4c53-9a29-d8b9443f3429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:901","original_object":"UniProtKB:P32239"}
{"id":"2ad0c4eb-fb80-4ef4-871b-b1b4eb42cada","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:808","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:e02a67d7-173f-490d-a704-ca8fbb36c197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:808","original_object":"UniProtKB:P49682"}
{"id":"cf59e510-a341-4671-bc45-36a8d6877958","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95060","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:0550882a-4be5-4c4f-b458-82cfd05c4729","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7379","original_object":"UniProtKB:P24941"}
{"id":"15adcef7-2879-40bc-a60e-488bd32060e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46885682","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:0f5ff501-00f1-495a-a88b-7442088f4bf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3134","original_object":"UniProtKB:Q02769"}
{"id":"d06ba447-fa9a-456a-8e5d-67add24b54c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45378170","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:ad0372e8-505b-47ed-b5e3-8a8ad6440d44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12616","original_object":"UniProtKB:P42336"}
{"id":"9d582bcb-9948-4161-849e-20cb1c851194","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358786","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:6a520c9c-e9a4-487a-97bc-fca5c9cca8db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12004","original_object":"UniProtKB:Q03431"}
{"id":"d5f09474-813b-4bb7-89e5-01e9a85ce90d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121364971","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:1b0224fa-2eca-4400-bfc3-3df82dd15d3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13101","original_object":"UniProtKB:Q9NWZ3"}
{"id":"7d4422d4-d8b8-4ae4-b507-9f32ac0938ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2261HH611H","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:9054575c-2678-47d4-9cfc-f983bb8c6f92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9907","original_object":"UniProtKB:O00329"}
{"id":"c0a2f781-ceab-4ded-830f-103dddcbea48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366968","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:cf4abd1d-3c8f-4a54-8b68-64e6fd0a5217","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11775","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"455819cd-3f3b-4c28-868d-d7af4b01913d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190962","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:9b9237f0-0852-427a-8000-b2de147b68e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2460","original_object":"UniProtKB:Q8R4D5"}
{"id":"dfd1f4c5-80a0-4cd4-a6e3-3944330c381a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:3b795a7e-ddbc-40a2-937d-df063828e429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P14842"}
{"id":"a2c866e2-7b74-44c5-b07b-c3e07d8ac8fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123984","predicate":"biolink:affects","object":"NCBIGene:348980","sources":[{"id":"urn:uuid:c7e15720-9283-4921-8d47-1c06dc2e29f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2359","original_object":"UniProtKB:O60741"}
{"id":"0b6d19f8-b7c8-409c-8a06-dce8119a2a3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118110201","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:0bffc69e-4d2d-454a-a53c-7847e298e7b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12320","original_object":"UniProtKB:Q12866"}
{"id":"c7dad7cf-bbe8-4a5e-918c-e5772fdfbd8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24863112","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:4613b151-f507-4680-bc4c-14d96fde1b3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8205","original_object":"UniProtKB:Q13464"}
{"id":"0ece0001-434e-4e31-8d40-0b958ae47583","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15558","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:8977649e-8d66-4786-8547-15f2f577e6ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3401","original_object":"UniProtKB:Q9NPC1"}
{"id":"5e39dde7-b872-4167-a87f-64c1e8412e6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900912","predicate":"biolink:affects","object":"NCBIGene:55589","sources":[{"id":"urn:uuid:8cb2414a-cfad-4a12-a30c-48229be7d5bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11893","original_object":"UniProtKB:Q9NSY1"}
{"id":"9012c69e-8630-4a85-acfe-2d99a73274ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69477","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:f9a80126-a4e9-482d-a155-957b32a5392f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11094","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"f160035b-b79e-44db-b85d-24977a392999","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7633","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:cedb78ae-e7e2-4e12-a404-84b606bc0a8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1630","original_object":"UniProtKB:P35372"}
{"id":"be14eb93-fac7-44f3-9cab-82ab2350bff1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c1b80993-87cb-4ac8-a184-8835f0e3a609","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P28221"}
{"id":"711540da-0824-4e7d-bfc1-1d5ae08d305b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57336812","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:8b2eb125-a7e0-4d55-b240-31e1fb2a73a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9387","original_object":"UniProtKB:O60674"}
{"id":"4a2a17e8-0952-4845-b5b9-b5f37b32ff47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76607","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:33db0be0-57c9-489c-8180-904ff4b74b6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7352","original_object":"UniProtKB:P24530"}
{"id":"893e63ab-96ca-45ad-96fa-0de17bb4a066","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QOV2JZ647A","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:335d5eff-0be3-47fa-8f8f-9fc927b6c849","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2707","original_object":"UniProtKB:P37231"}
{"id":"b7fb44f5-5cb7-415d-b5cc-d7b0e1abc489","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81391","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:847186e5-e23f-4fd7-bc1d-5787556201bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1267","original_object":"UniProtKB:Q9Y5N1"}
{"id":"e27888c3-0442-4e93-a989-1b9bfb44f829","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2557","predicate":"biolink:affects","object":"NCBIGene:29731","sources":[{"id":"urn:uuid:43703e29-f48c-43e2-ba04-b11395f51441","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2557","original_object":"UniProtKB:P15384"}
{"id":"c7d93b9f-7bc3-4bf3-a208-cf6f010e46a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232390","predicate":"biolink:affects","object":"NCBIGene:81779","sources":[{"id":"urn:uuid:15adbc01-6095-4313-8c08-8a849d5420c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1153","original_object":"UniProtKB:P23811"}
{"id":"57bfda77-6d86-48a6-befb-4d6388ff6bab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CW55R761RE","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:4091ac5a-60dc-4133-bd8d-a72778b14d85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:290","original_object":"UniProtKB:P10980"}
{"id":"b69949e5-d354-417f-817f-00a13c35b49c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:35fde695-b810-4c0e-8c95-7041961fe56b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3300","original_object":"UniProtKB:P19020"}
{"id":"12fd4814-8c10-4789-b946-690091b5d3f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3215","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:c57a6845-5cb4-4f0a-8d3a-c75ef7560811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2397","original_object":"UniProtKB:Q14524"}
{"id":"1e08d5a5-1883-4c45-a62c-c758412695e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:275dba3b-0ce3-46f0-a667-7df367c59882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P23944"}
{"id":"cd1c217c-836c-4766-8b7d-35bba851a321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13450","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:da6975d8-f0d1-450a-b6f5-514bed27a0e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13450","original_object":"UniProtKB:P10721"}
{"id":"b3268029-6dc2-4664-9ece-77177e49e501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:f7531e27-9302-4e39-9542-bb899839174b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:P42336"}
{"id":"1e0cf016-e115-419c-a434-f2190ea42eb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4293UZ16CU","predicate":"biolink:affects","object":"NCBIGene:1071","sources":[{"id":"urn:uuid:d9482813-dc36-40cc-95a7-5e99c7bc795c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10721","original_object":"UniProtKB:P11597"}
{"id":"d1cc4459-c2f3-4a71-9b9d-1a7e5fc9c8b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162526515","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:6393e840-5e44-486e-a1af-36a2e57e05f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12141","original_object":"UniProtKB:P53350"}
{"id":"623f6e67-51b7-45c3-82c1-3daecc4e2596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42549","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:ada0e91e-e3b0-4028-8aa8-de28162aac96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4070","original_object":"UniProtKB:P42261"}
{"id":"b029c204-aff0-41bb-bd7d-b1e1386f27f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92848","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:8e148c0c-d99b-4039-99ec-ce299d83a365","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3286","original_object":"UniProtKB:P25099"}
{"id":"d16d0378-b051-402d-867b-1fe31b18ab9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8207","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:9986493e-0cbf-49de-bc32-51932b578eb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:305","original_object":"UniProtKB:P08173"}
{"id":"13f17343-6830-456b-ae12-692cd89f7a47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39285","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:6537681d-eda9-47a3-b3db-6428382e0e57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6292","original_object":"UniProtKB:O75762"}
{"id":"5a1d4f90-c38f-4162-a9dd-c28c39682a38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:6868","sources":[{"id":"urn:uuid:ae833e25-0343-44cb-a59a-87836e9a067b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P78536"}
{"id":"b53268f2-c11d-4bfa-a386-2bb59fa2dc87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10045876","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:8a34834e-a371-43c6-8bc5-9d58168c89b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:468","original_object":"UniProtKB:P0DMS8"}
{"id":"3b191988-3c40-40cd-9cc0-dc2690212e55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10357","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:88150ed5-9b26-4733-bc3b-0e6f78dd4307","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13282","original_object":"UniProtKB:P34972"}
{"id":"30ca0e25-f750-467c-a0fd-8ba4595dcaca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZPX6CRU43V","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:94011d05-8355-4b89-8cd5-14a086a6d593","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11409","original_object":"UniProtKB:P11802"}
{"id":"6b1f2187-1880-4045-ba4d-c857455a457f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:f8c8a722-2792-4922-9a60-7deb7c9c9742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P42336"}
{"id":"ed39d86b-248b-47c8-843d-42f62ef6e3d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:8b3b86f2-4354-423c-b543-cd56e4c955cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:P23385"}
{"id":"51d609c5-1234-48c7-b3d0-2f9a62d2af7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:115002","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:33e6e40b-e320-42c1-89d8-9da937c25d14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1851","original_object":"UniProtKB:P25105"}
{"id":"33282643-58a0-430a-a82f-82535d25c8f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1998","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:6998cf17-40ea-423b-8359-574262829d2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1998","original_object":"UniProtKB:Q9NSD7"}
{"id":"81aed2b0-a206-42ff-b32e-650a53cd8dd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134938","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:3bf6f5c9-23b3-475c-8645-f3280372490c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9866","original_object":"UniProtKB:P24557"}
{"id":"876b4a47-f4bf-4324-ba3d-d4975f1cd6f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17689","predicate":"biolink:affects","object":"NCBIGene:2835","sources":[{"id":"urn:uuid:479c7ab8-9b4f-4d61-9b6f-aca71bd7023d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4032","original_object":"UniProtKB:P47775"}
{"id":"57ac2849-e942-42d9-a0e4-aaf02d4281a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13353","predicate":"biolink:affects","object":"NCBIGene:22427","sources":[{"id":"urn:uuid:eba62bc2-0b48-4d70-b44c-6ac7cf2a6643","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13353","original_object":"UniProtKB:O09053"}
{"id":"694f7405-15c1-42cc-925f-978814de4fe8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44185","predicate":"biolink:affects","object":"NCBIGene:6573","sources":[{"id":"urn:uuid:8eb79269-4898-4e5c-a03d-07d0a6d45d12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4815","original_object":"UniProtKB:P41440"}
{"id":"21617b39-88da-48d9-b8a6-0ac63dbde3d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9106","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:b080a8bb-af65-465b-b66a-198cce6decbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9106","original_object":"UniProtKB:P07333"}
{"id":"e0512c1e-a8e1-4612-8718-a2b191583a30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136034","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:706d0385-8268-4116-905d-6d26b949010f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1324","original_object":"UniProtKB:Q01726"}
{"id":"0ed86aa2-d1aa-4feb-afd8-79247ec07d75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2012","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:7ba578f0-cc3e-409a-93b2-1049afff2db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2012","original_object":"UniProtKB:P35346"}
{"id":"8c942f8a-ad3c-424c-987e-dfdd1f71fbef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104024","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:f75e8efa-37c1-4fda-930f-62956351e61e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3388","original_object":"UniProtKB:P41594"}
{"id":"3a7afe5c-408f-4e59-b16c-a623c8515044","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RWS6U82B77","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:2b59bf73-3801-4271-97c2-aea435456166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6214","original_object":"UniProtKB:P23385"}
{"id":"30bc12d2-345b-425c-881c-72c2a67aba76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:140478","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:da00e1cf-3352-47fa-b05c-82dbe0dc75f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5775","original_object":"UniProtKB:P29371"}
{"id":"48d24697-e340-46cc-bbbe-cdb58d44b68b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LFR1253W75","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:475b2462-0638-4ac8-b4af-afbdce696322","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5946","original_object":"UniProtKB:P24941"}
{"id":"582674ae-a551-4885-bc75-8ed7da56b432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9852833","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:5226b7da-211e-46b6-b6e0-781360c598e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:868","original_object":"UniProtKB:P32238"}
{"id":"2e085914-04c4-408e-9801-41b0641f2ea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124221649","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:4d647c1d-51dc-49d6-8f6a-657fccffba42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10280","original_object":"UniProtKB:O43613"}
{"id":"7106ecfb-a225-43ef-9682-585574904fdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366973","predicate":"biolink:affects","object":"NCBIGene:51185","sources":[{"id":"urn:uuid:7c223c8c-9c4a-4308-af87-b2925073850c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11799","original_object":"UniProtKB:Q96SW2"}
{"id":"0920b1bf-d70c-4701-906d-effd2293f818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5283052","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:5eac383c-29e6-455b-807e-fcc74dffdc37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1904","original_object":"UniProtKB:Q9Z2J6"}
{"id":"5e8cdbc1-f597-4659-9389-c26bee582a30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146444831","predicate":"biolink:affects","object":"NCBIGene:1235","sources":[{"id":"urn:uuid:a90c6dee-23ed-4e65-a255-d045962da049","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12765","original_object":"UniProtKB:P51684"}
{"id":"0cb99683-2696-4496-9751-5c9882596bb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188539","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:1990d9e9-0011-43ec-af05-aaf22324a6cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2928","original_object":"UniProtKB:P21453"}
{"id":"48e1dd7c-695a-4b4d-b11d-11c41be0bce3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31882","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:f684d2c9-ecfc-4e1e-b254-3c8c18130ab0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4268","original_object":"UniProtKB:Q05586"}
{"id":"e9228289-c77f-4234-a16f-860805307d46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5063","predicate":"biolink:affects","object":"NCBIGene:4352","sources":[{"id":"urn:uuid:8104ff99-a227-4a90-8f43-2aced6e958a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5063","original_object":"UniProtKB:P40238"}
{"id":"c2525353-6448-4f43-af7d-be3ffb3b1894","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9860053","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:c8270fc2-9ac1-43c3-8582-8774a11cfc00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1261","original_object":"UniProtKB:Q9QYN8"}
{"id":"957a0c52-af3a-42b8-b15a-bb344c86424d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817437","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:4eef1112-b792-4dbc-9f0a-6087ee2193f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2268","original_object":"UniProtKB:P41587"}
{"id":"fb67926c-bf32-4259-b25a-185ef20fcbd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37537","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:15d8df1d-1870-45f8-8534-16e48808c4e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2341","original_object":"UniProtKB:Q9EPK8"}
{"id":"43569fd5-76fb-49fa-b0d4-f2dbcaef3317","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7167N7AJJR","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:ada6187f-6244-4118-848a-2b47ea2b7c86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3466","original_object":"UniProtKB:P07550"}
{"id":"25cf0767-6ed0-468e-bc14-9db944729eda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24893979","predicate":"biolink:affects","object":"NCBIGene:56827","sources":[{"id":"urn:uuid:a2dfbf9e-18d2-47de-8ee8-e8632b9e4036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7723","original_object":"UniProtKB:Q9Z0Y8"}
{"id":"9abdbfc1-8d94-4dea-8870-7ca1bc17bf83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12514","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:468eda7b-4375-4082-bc69-8823c80e616a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12514","original_object":"UniProtKB:P21730"}
{"id":"a8f6419b-fdf0-4586-93b9-98ae7fd2208c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:75c2cc88-4931-4b9f-8737-05743a4f4b6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P43115"}
{"id":"1ace8b82-ea15-4ad7-bc14-a53da21b5626","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6133","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:e0ff0dad-b9fc-4a20-8a5f-71fe36b1c523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6133","original_object":"UniProtKB:O88626"}
{"id":"74338b08-e35a-41d0-9cd0-9bfd531909bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4615193","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:5f0ef1c1-4a5c-4705-8ce5-d9b4dded8115","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4141","original_object":"UniProtKB:P42262"}
{"id":"8b61f819-c12e-48ef-a8f8-631a0469997b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10389639","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:e2e8f9ab-3ba3-4bc6-bce0-fba1414523cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4062","original_object":"UniProtKB:P13631"}
{"id":"45c16857-33a1-4120-86d9-c03c49b663f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57404276","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:7867f118-d346-4643-89bd-357481a6d095","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9378","original_object":"UniProtKB:Q8NEB9"}
{"id":"a49677e9-f8d8-4e1c-8b95-81dba9ddcbaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64207","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:bc22f5dd-51f4-4805-b7a0-bac5397858b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:175","original_object":"UniProtKB:P28223"}
{"id":"1368eb40-c5c1-4373-958d-d25b6cee4d29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167662","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:8669f39e-683c-498b-a18c-f2d6d981a592","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8943","original_object":"UniProtKB:P04049"}
{"id":"86b2a51f-06ca-47c2-a652-e3d1a61e428c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76285486","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:4ba56328-a55c-46df-96ce-43d0e4e8f46a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8238","original_object":"UniProtKB:Q96KQ7"}
{"id":"39c85fe0-d181-477a-b32b-608d9917f2dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:1018","sources":[{"id":"urn:uuid:3b895d7c-6374-4ae0-aa01-839f72e4378f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:Q00526"}
{"id":"4e5e695b-c657-4202-9e24-9e7ef4250026","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53319341","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:091976a1-c8d9-47d0-83da-3ddad724304a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:406","original_object":"UniProtKB:P30542"}
{"id":"83d45dac-e447-4bf0-af8a-7fa05b558715","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:0c2e4dfd-baf5-462b-8892-a388a287eec4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P29274"}
{"id":"ac8e2276-6b21-4ad7-bf15-f71bd7f06576","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125653","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:b5e20dfc-936d-4fe4-9833-758f24907258","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:217","original_object":"UniProtKB:P41595"}
{"id":"075c203c-5e70-4cde-85fd-c8fa02bac397","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:4616da31-7e78-41c4-b680-0eedc3fc94b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:P35968"}
{"id":"0bedf579-eadb-425f-a28b-7ccdba5f0eb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2561","sources":[{"id":"urn:uuid:bb6573b6-050d-4fbd-b1aa-a7bec420eefc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P47870"}
{"id":"e3395255-3e62-42fd-9097-81f3ed001c74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9916282","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:ee9b7873-6201-4ab6-b0a0-05d76f97c62f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8355","original_object":"UniProtKB:Q96GD4"}
{"id":"5ff21b61-ef21-476a-b2c8-35249d496123","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126619980","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:78d0cbd8-bef9-4443-86f0-fd47776fa0db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10564","original_object":"UniProtKB:O60885"}
{"id":"47cafe0a-1134-4eaf-b36f-e3f6b8a0cb34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:639eec11-3088-428e-b78b-77bdbea37b79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2181","original_object":"UniProtKB:P30518"}
{"id":"324c662e-f54f-4891-94af-5b134e2cfb7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IC1B8751F6","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:51a65ad1-09e5-42d5-9198-aa7d7800fdea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13884","original_object":"UniProtKB:P15538"}
{"id":"65327e60-1f7a-4611-adb9-dd6f1ee46a56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:2242","sources":[{"id":"urn:uuid:87f4c103-ab10-4141-870a-0a12e9b74c12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:P07332"}
{"id":"a5a28620-ff92-4b74-aadf-2dc848f328ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:b9ddb97e-5662-4d9d-9068-882fdb853f8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P30966"}
{"id":"45acb249-3a8d-4d3a-950d-9d8c3c1da984","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:763","sources":[{"id":"urn:uuid:2722a5bb-da55-4e93-bd8a-d766753c59a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:P35218"}
{"id":"02aa895f-0055-44d7-a5e1-6de00a72f5d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:d580e195-aa7d-4d32-828b-72622cf4edba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P35916"}
{"id":"34bc5c48-966e-4356-8864-900d1b07fbd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7WF5ZLL4D9","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:98308c91-8a64-4cbc-bfd4-34d6fe2190bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1402","original_object":"UniProtKB:Q14416"}
{"id":"788cbfd9-a0d2-4803-994b-ecb8d6912c2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11510579","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:2352ad15-8e0b-4eec-81b8-15af3daa612f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5808","original_object":"UniProtKB:P47900"}
{"id":"2e9959e9-7370-47b5-abe7-d73aae93fc8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49858118","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:97772fb3-aff4-4697-a707-30c4b116776e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6224","original_object":"UniProtKB:Q14416"}
{"id":"126cf59d-7c1c-4748-8a91-932d068388f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:687","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:f99b0354-ccf3-4de3-8911-cd8803e873bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:687","original_object":"UniProtKB:P30988"}
{"id":"79a04d25-0e39-42f4-9c06-8bb98c746e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:24e78cd7-a673-4384-9db2-12697f863099","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P35368"}
{"id":"db13a1f2-8228-47a2-94b0-992fd6fd34ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32347","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:e841615a-3e3b-4690-8f66-257da41b9639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2304","original_object":"UniProtKB:P23979"}
{"id":"55baa316-240b-451a-9b75-de0e99abab8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71818575","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:76e55688-82fc-4940-bf40-e0b776c4b092","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10284","original_object":"UniProtKB:Q13507"}
{"id":"458819db-20d3-4212-a920-d813885d05dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:364453","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:41e158a4-04ce-4c84-8455-866cb412dd17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7141","original_object":"UniProtKB:P35354"}
{"id":"cc950226-9d4e-4732-a591-68bdea7c87e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:762","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:a101c9d1-5fbc-4010-aa0d-9ec9a88158fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:762","original_object":"UniProtKB:P41597"}
{"id":"ba4f7e9f-eb56-42b0-aa6d-261a1d075b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:f45d403f-2d4b-4e36-b9e6-fa048b7bc50e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:Q04759"}
{"id":"2494943f-6066-4a35-b3ce-530848c47ca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132585191","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:574d7599-d512-410b-acc1-9bac13ad4e84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10380","original_object":"UniProtKB:Q9HB89"}
{"id":"68b9c6a0-39ff-49d4-a668-e49d437e18f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11224758","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:d462560a-c6b3-4ec3-a70b-f704712ed15b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8435","original_object":"UniProtKB:P34969"}
{"id":"2f1312f5-e404-45af-9bc1-a684aee887ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:1bc90e68-8022-481b-bda2-0220d4825f35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:P15056"}
{"id":"4199ebbd-da3b-41f4-ac03-135a2cc86788","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3037022","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:3074cc47-b7cc-4850-95a1-849c37d4da66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4763","original_object":"UniProtKB:Q05940"}
{"id":"e7d4b1e4-3d99-46bb-a32b-5556d9c8333c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6690","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:5ceba410-6384-4796-b462-3c7ed0496f9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2402","original_object":"UniProtKB:P48542"}
{"id":"8b1c2ec6-1614-4295-8a5d-8287bccc166c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47426","predicate":"biolink:affects","object":"NCBIGene:6557","sources":[{"id":"urn:uuid:ebbfa281-ec85-4c35-9983-8e584b5b9814","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4839","original_object":"UniProtKB:Q13621"}
{"id":"371c397b-3656-42af-89c8-28f9b8e3f316","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:061e1804-7f63-4949-bc56-0bae54ae53e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9BX84"}
{"id":"6d4ec7e4-08ef-4669-8b15-faec36315d5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8447","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:710fc128-96da-4322-bf3c-fd10a03929e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8447","original_object":"UniProtKB:P47900"}
{"id":"1375c730-b2f1-4ccd-9501-7b40626cf2a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73289","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:b3efe59b-f5d5-45e8-b208-33afe6e4033f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:543","original_object":"UniProtKB:P07550"}
{"id":"e1f81f5a-2aec-42e2-96cc-aef22b72d033","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BCV386QGUZ","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:b9ef6efe-c924-46ad-b5a6-cb2d8b4004b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9731","original_object":"UniProtKB:P04150"}
{"id":"c784762b-bada-4a7f-9ab8-380fba9cfe4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13273","predicate":"biolink:affects","object":"NCBIGene:381489","sources":[{"id":"urn:uuid:86e34e6e-00cc-4ace-ab60-6f9fa4bea02d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13273","original_object":"UniProtKB:Q6R6I7"}
{"id":"49d81b63-adec-48e8-b858-8f099f59bca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41607","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:9b2a5b5c-85ff-438b-8c0d-f4ed8f42b8a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6288","original_object":"UniProtKB:Q6RI86"}
{"id":"ccdcf170-031d-4b1a-af0d-055b97508b9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135524168","predicate":"biolink:affects","object":"NCBIGene:9261","sources":[{"id":"urn:uuid:78f110cf-0d29-4b53-a941-8a7b8d0a24a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8178","original_object":"UniProtKB:P49137"}
{"id":"1def2fba-da14-4abc-aa28-720691dd91a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188072","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:3436ad6c-29c5-4285-8626-894099f4c6ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:67","original_object":"UniProtKB:P28222"}
{"id":"ff975b75-38d7-43da-8021-ca6989ba3f54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177605","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:a204396b-bfb7-4c7d-a643-9f08cf880b94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10651","original_object":"UniProtKB:P35372"}
{"id":"d78c3eac-5028-4643-bb62-b1559dec9fe6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:9010a57b-2c80-40ea-92cc-9e8d7a996ead","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q8TD43"}
{"id":"fde8d0a0-6e35-4a41-aa00-074ad22a6766","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11545181","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:34d194a5-8883-46ca-b593-63448a4d9b8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2930","original_object":"UniProtKB:Q9H228"}
{"id":"cf299f30-e0af-4db4-bed6-2802d8d67259","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101882900","predicate":"biolink:affects","object":"NCBIGene:7357","sources":[{"id":"urn:uuid:8758fdc3-35ee-4f3f-bd5c-6775891a60c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13906","original_object":"UniProtKB:Q16739"}
{"id":"364ac6a5-6007-4ec3-ba2e-737aeff54f95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:30814","sources":[{"id":"urn:uuid:8683ddee-7e5d-440e-8043-4a3287526f21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:Q9NZK7"}
{"id":"c0f6c68e-1bc8-4839-9338-9b7f828582d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6106","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:a9cc150c-2867-49d8-879e-d71ef6237daf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6106","original_object":"UniProtKB:P47211"}
{"id":"ffe6c221-fdcd-4aa4-9929-2da6b6c2d76e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95058","predicate":"biolink:affects","object":"NCBIGene:8986","sources":[{"id":"urn:uuid:2ba9734d-7403-4fa1-9a84-983c86a6a867","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8763","original_object":"UniProtKB:O75676"}
{"id":"fe2baf6a-6eb9-4b0b-9b47-e95bbbe9f6ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4653","predicate":"biolink:affects","object":"NCBIGene:5151","sources":[{"id":"urn:uuid:efc00c76-b23a-42d3-b62d-2a34f2f55a70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4807","original_object":"UniProtKB:O60658"}
{"id":"3bb44e37-b94e-45aa-aa45-be23e990f3d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146212008","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:17191ae7-60c2-4145-941a-5d91ee9c1d3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13457","original_object":"UniProtKB:P78527"}
{"id":"0b31d0c2-4228-45ed-9df2-dfe802be4ac6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9949648","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:0ab8e352-55db-4501-8ca8-597d3da11975","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2600","original_object":"UniProtKB:Q9NR82"}
{"id":"268cf3f0-441b-45b4-841c-731d2cdf0c2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94306","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:327ebe11-7804-4ffa-af07-e75383e50233","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9664","original_object":"UniProtKB:Q9BY41"}
{"id":"ce30774f-b246-4020-a0fb-69c10f0eef8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:895OJP78MJ","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:6c920987-03a9-4d9c-812d-e8545090fc76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:968","original_object":"UniProtKB:P14416"}
{"id":"7640f8b2-aafb-409b-9c81-7687abba1e1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68478","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:5ab8f07a-670f-4151-a4bb-77f30d1d7892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5889","original_object":"UniProtKB:P42345"}
{"id":"999c58b1-8e6a-46a1-a6ee-6297ddc9b267","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6690","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:0525b7c7-76f6-415f-99fe-fb1644c21fbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2402","original_object":"UniProtKB:P48545"}
{"id":"52f08a71-1a34-43b3-a291-a6177110dfb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:b918ffe8-4572-4869-949c-4e7b472348ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:Q63634"}
{"id":"03114570-a8f8-43a7-a13c-6d2125e77434","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54585418","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:25d20349-93a3-4d79-beea-32e93bb300f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:745","original_object":"UniProtKB:Q9Y2T6"}
{"id":"4616bd97-21ef-4d03-9e55-beab4a4adad2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93368","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:54922da7-28c3-43de-919a-9f2643b692c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:173","original_object":"UniProtKB:P30994"}
{"id":"a4211d7d-9b54-4c9b-af17-8c43f06a08b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46175162","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:4f9d2b1d-f52d-4967-a6f9-6ef389050912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8578","original_object":"UniProtKB:P14780"}
{"id":"ab59acd7-0a81-4772-b678-d5da2f7c51e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145967606","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:93295d2f-1057-49fa-91a4-ecf9be18ba94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10670","original_object":"UniProtKB:O00763"}
{"id":"8149f1fe-9586-4404-b020-3d446ce7c4a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817404","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:3ea66a03-bc46-4d9a-bc0d-e5504d43aafa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1295","original_object":"UniProtKB:Q99705"}
{"id":"7f8bf172-4074-4162-b5ef-d31b4f57e090","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:314","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:418a4a89-2575-4aaf-9e8d-4f73aaff6cd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:314","original_object":"UniProtKB:P20309"}
{"id":"f7db3be8-4158-4514-b41d-d9b54240c49e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9825034","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:dea3afcc-d4f8-491d-a574-0972e49821d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9680","original_object":"UniProtKB:P51677"}
{"id":"b3312548-facf-4606-8c63-677486a89a68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312460","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:9f024908-298d-4c27-a904-d1d41189888d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13326","original_object":"UniProtKB:Q9NYV8"}
{"id":"3a79fcab-5234-4ac6-9b8f-952761344364","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75984","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:ec54b339-e72c-4d87-ad38-b8ebe184a8d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2560","original_object":"UniProtKB:P16388"}
{"id":"7b3b5667-0feb-4ce7-bf74-bdd8e5232658","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91465","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:ad300fe8-6c5e-4431-bd2d-8989a1caaf02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8008","original_object":"UniProtKB:Q96GD4"}
{"id":"24ff5f06-eb45-4beb-a3e3-b80152715e21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6916","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:89701766-42f6-4a08-8835-f905bd4c7b9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6916","original_object":"UniProtKB:P30556"}
{"id":"98d965ed-4030-4dd3-9d92-285bae409e57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149601","predicate":"biolink:affects","object":"NCBIGene:47","sources":[{"id":"urn:uuid:fe66d0f1-0380-459e-96ca-10b007f31da9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8321","original_object":"UniProtKB:P53396"}
{"id":"7e92d095-ced5-4fb4-a1c2-10d7965b12bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:13aa51b6-6a3c-418c-9010-0773800b647d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:Q9UM73"}
{"id":"7a0dcb09-5019-4075-950d-52eb9d65466b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177401","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:0b958148-726c-4aac-94b4-dd09951b1a11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2886","original_object":"UniProtKB:P56718"}
{"id":"c17bec90-985a-4145-826c-6f6f9df9b4be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:187403","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:c7ea9e7f-a6a9-4c42-a17f-ed3031555aa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2753","original_object":"UniProtKB:P55055"}
{"id":"7b82b0d7-40ea-4563-a7dd-d33743e3f351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:b3f33b0a-6d5c-4f21-a542-65bb382a8fe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P28334"}
{"id":"3673cd18-4440-43fb-ab5e-7432efa2bb24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155567226","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:99f599b0-508d-42b4-8625-fd440ce54df2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11479","original_object":"UniProtKB:P56696"}
{"id":"d7955c16-fe20-4197-93a7-259fc3a19213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V4E0A9M44Q","predicate":"biolink:affects","object":"NCBIGene:5313","sources":[{"id":"urn:uuid:030a9f36-4e1a-4340-bec0-15ddc6a2a49a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11975","original_object":"UniProtKB:P30613"}
{"id":"1c25f539-69d1-4588-a4dc-6960c86c2a7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8426","predicate":"biolink:affects","object":"NCBIGene:50833","sources":[{"id":"urn:uuid:f600ba33-e6e3-45e9-b292-d5b4302c770d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4357","original_object":"UniProtKB:Q9NYV7"}
{"id":"1ad5f239-9e71-40d6-a1fb-db1d4da4eadd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93781","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:77fb7caa-6e8f-4399-960a-c6ee81d833ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6030","original_object":"UniProtKB:P11802"}
{"id":"df131773-fbaa-4ce9-9614-056510caa116","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:b2d11861-4857-4c33-9083-fb71f17ecca5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P30542"}
{"id":"77270a91-2ce7-48f4-bb85-1f42d6ba5bb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030519","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:5c123625-92dc-4351-b7cc-11c9d17d4d09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10424","original_object":"UniProtKB:Q13464"}
{"id":"19c152c6-002c-4381-95b0-26b75a31277d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:286b6c55-d326-4771-b8b1-8f82dffdcfac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P08588"}
{"id":"5a8c2ead-8f43-4ba7-ad17-e7b8e6561f3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:12238216","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:cea68332-bddd-4ecf-84f5-68552177cd90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3096","original_object":"UniProtKB:Q02769"}
{"id":"0dda0c09-bd06-4540-ba7c-93d5e62d54de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25195323","predicate":"biolink:affects","object":"NCBIGene:64078","sources":[{"id":"urn:uuid:11168933-a723-4b04-8b8e-28cc5c625e74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8837","original_object":"UniProtKB:Q9HAS3"}
{"id":"1edfb4c1-5cf0-4a79-aaf0-b0e049dfa873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91091","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:7a275ce8-cfbf-4b58-a261-8142c603e1de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8014","original_object":"UniProtKB:P06493"}
{"id":"be7c7d08-1780-47cf-9851-df284a246bba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133816","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:e0ae09f2-092a-4815-b7bb-e2bdbd794114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2310","original_object":"UniProtKB:Q12791"}
{"id":"cec7a93b-083f-424f-8d49-3efb90e38620","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6335948","predicate":"biolink:affects","object":"NCBIGene:81657","sources":[{"id":"urn:uuid:213120aa-4415-4d77-adfb-354198369163","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1081","original_object":"UniProtKB:Q9Z0U4"}
{"id":"12fc5efc-362e-4d14-885c-f1b783ab4b55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29566","predicate":"biolink:affects","object":"UniProtKB:P0AES6","sources":[{"id":"urn:uuid:f70947d5-0c78-444a-8dec-4d2a43df509c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10988","original_object":"UniProtKB:P0AES6"}
{"id":"05b78d17-acfa-473f-9dc1-3756b0c240e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6077765","predicate":"biolink:affects","object":"NCBIGene:10411","sources":[{"id":"urn:uuid:7fd9c76f-26ec-4d35-840b-7e0a77c6f668","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7917","original_object":"UniProtKB:O95398"}
{"id":"7f7cee88-8609-4f6f-9257-d82afc22b0cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:517603c6-e821-4de6-8591-d2f8aa9815f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P30557"}
{"id":"743b2510-efc3-424b-8bdd-a1b91e491cef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32184","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:6a6711f2-fade-487f-ba6c-038cb093f4d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6952","original_object":"UniProtKB:P10826"}
{"id":"f67ea613-7591-4632-bc4f-0f677d7ee117","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9936595","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:31b65730-7e6e-4c8d-8b91-283ba7984a61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1921","original_object":"UniProtKB:P34995"}
{"id":"ca350be9-fc51-4c77-9a75-f03247965d77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53324620","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c96976c5-f734-4dd9-bf32-2da5554e4a27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:262","original_object":"UniProtKB:P28221"}
{"id":"7791265a-e550-4bb7-99d8-21adad8509f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3330","predicate":"biolink:affects","object":"NCBIGene:823","sources":[{"id":"urn:uuid:e36768ff-4fd9-46a0-995e-1bf0b2469f4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11643","original_object":"UniProtKB:P07384"}
{"id":"9d760700-06c6-45a3-84cc-e8cbe65f0892","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4D6Q6HGC7Z","predicate":"biolink:affects","object":"NCBIGene:2550","sources":[{"id":"urn:uuid:00280393-a06f-438f-9882-83360987753c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7705","original_object":"UniProtKB:Q9UBS5"}
{"id":"5bb78c74-d643-4556-8be4-4f70cfb4663f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4Y3VYY2X83","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:0482b169-8ba6-4ad4-a246-3bb9ff970591","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8064","original_object":"UniProtKB:Q13164"}
{"id":"205cc5d2-6a91-4a36-a97f-8e06f97de57f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:773933","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:c2f922fc-1268-4918-9f6d-5ef825dd712c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11276","original_object":"UniProtKB:Q5XXA6"}
{"id":"b21e9b2c-8d17-497f-988d-c08595577cd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393285","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:2f911436-2ba7-4b2e-93c1-a25ad80137b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10351","original_object":"UniProtKB:P0DMS8"}
{"id":"725d2259-287a-46e2-9cd1-c49f90a79bd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:c2eb5aa7-f16a-4da5-b9b9-b48a6cb5bf0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P35462"}
{"id":"1fc2f54f-6fa1-47f9-90f5-f8fba4872381","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17027464","predicate":"biolink:affects","object":"NCBIGene:1536","sources":[{"id":"urn:uuid:8eeb5eaf-6a7c-4747-85f0-9b08b09528a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9935","original_object":"UniProtKB:P04839"}
{"id":"0db682dc-faa0-434e-897b-388ec0d60b72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5182534","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:0408a0e4-a78a-40bf-b80f-c9cd6993450b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12109","original_object":"UniProtKB:Q96RI1"}
{"id":"91d7a9c6-14aa-4a2f-a278-e1779b48cc63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17364","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:0ee7fbd8-fa38-41c8-aa6b-a8e654523581","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6511","original_object":"UniProtKB:Q05586"}
{"id":"1008a78d-e065-40d3-98e6-153f118c215f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:2045","sources":[{"id":"urn:uuid:bd1f76b3-6c89-428f-baf3-5343eaa7b979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:Q15375"}
{"id":"2518025d-79ef-4842-ab1d-5971fe66064a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2087","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:2b57753d-a1b3-4d18-a2b8-420173964cc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2087","original_object":"UniProtKB:P25103"}
{"id":"7a76ce7d-e1a4-4499-9f4a-bfbf1ce09487","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141346","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:ee496407-4859-4006-85d8-86f2d74275e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9512","original_object":"UniProtKB:P07550"}
{"id":"ff1d6ef9-9672-4c01-b68b-d941c8e9eeee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:3760","sources":[{"id":"urn:uuid:62c202f5-2bc7-4bb4-acf4-de7c2c58d44d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2340","original_object":"UniProtKB:P48549"}
{"id":"c710711a-247e-44ac-a93b-c01c579baf9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422757","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:c75b1e64-75a5-4dba-a922-991503f0380c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13028","original_object":"UniProtKB:P0DTD1"}
{"id":"a2993e94-2061-4ee9-ac2d-42859c69b68e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71364","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:be420d4c-2be4-4d86-ba46-032884817bcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:667","original_object":"UniProtKB:P46663"}
{"id":"84a77798-5d3c-4bea-844e-b097d1136a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82698","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:5a85e4ce-ef37-4442-8218-6b6b0de155ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2890","original_object":"UniProtKB:O43614"}
{"id":"e6e95537-d913-40b0-8612-749b469a44a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817493","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:1e3b9702-61eb-4122-82ff-5131d0d7e5e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6247","original_object":"UniProtKB:P25090"}
{"id":"046b91a4-179b-4f70-bcd1-b936303f97a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2612","predicate":"biolink:affects","object":"NCBIGene:116745","sources":[{"id":"urn:uuid:50c991fa-61ea-4cc0-873f-c2515939b755","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2612","original_object":"UniProtKB:O54853"}
{"id":"af596e2c-9c63-40a3-8b47-16c9f152056d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:1783c3f6-a1ec-4f52-b14b-54f5f7fda2ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P08909"}
{"id":"954d9736-af03-41b4-84fb-6ba12dc582a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3347","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:30e61c05-bd5d-48fc-9445-97e247dc1d98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:587","original_object":"UniProtKB:P30556"}
{"id":"869a3e4b-dc69-442d-acae-0ab6c789cd58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4917","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:7e7403df-fc78-4f93-a7f5-9d6118b77c30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2425","original_object":"UniProtKB:Q8K424"}
{"id":"715e36de-c0f2-4dcf-b6c5-fb07e085f202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RA72G28VE9","predicate":"biolink:affects","object":"NCBIGene:85397","sources":[{"id":"urn:uuid:079ac208-0d76-44b1-a317-046db7bb4504","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7784","original_object":"UniProtKB:P57771"}
{"id":"9d11c6d6-2b4b-4a0d-9aaa-9e6f2a075a2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145966622","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:4816f3bb-997d-4fde-9889-06572dfd01a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12324","original_object":"UniProtKB:P49286"}
{"id":"39b38671-f088-410e-bdfb-642a29618ac6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95089","predicate":"biolink:affects","object":"NCBIGene:5592","sources":[{"id":"urn:uuid:3c72f841-6183-49bd-8be0-1ccd9db0a4ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7887","original_object":"UniProtKB:Q13976"}
{"id":"7e16f7c1-b19a-4304-b272-bc2e3ec7bee0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6904","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:da000411-bc69-4289-aeb1-f8b11d40c467","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:553","original_object":"UniProtKB:P07550"}
{"id":"32d8fe49-f624-42ce-af43-305f1f13c443","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:d7341745-3fc6-4285-aefc-23037feb13e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q62928"}
{"id":"cfdaf984-a477-4eb0-ac55-30d48e2fa772","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:74e745be-75c5-48d1-a7eb-33c57db9ed15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:O35433"}
{"id":"ee334b4a-798a-45bb-8a25-875d28910ba3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77967","predicate":"biolink:affects","object":"NCBIGene:2827","sources":[{"id":"urn:uuid:41071d18-5379-4f2a-bc35-86cf2ea1a84e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7802","original_object":"UniProtKB:P46089"}
{"id":"3d549ca2-bb7c-482d-bf57-e9fe8f0cf359","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122650693","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:eb977782-23b9-4ffd-a655-697775efa7a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12383","original_object":"UniProtKB:P00519"}
{"id":"c903c2e1-71af-45fa-8971-de845491b380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53262890","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:9169557f-5eac-4412-9f23-cf619c19fc74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6200","original_object":"UniProtKB:P51582"}
{"id":"15bf8c13-4ff0-46e3-bb15-530628dcb263","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11757797","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:2052f5e0-8fa8-415c-a9c5-268176a7f3b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:292","original_object":"UniProtKB:P08173"}
{"id":"1554a33f-02b5-4e6c-bed1-057b67d904c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754996","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:45ae2ec9-27f5-425d-8606-0486b79990a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:562","original_object":"UniProtKB:P07550"}
{"id":"bcfc70d5-920f-4211-940d-235164021394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46869947","predicate":"biolink:affects","object":"NCBIGene:24417","sources":[{"id":"urn:uuid:3748c181-8512-4777-844f-9906375eeac9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6233","original_object":"UniProtKB:P31423"}
{"id":"f67f7c76-c5aa-40bd-b98e-08756a615ab2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93752","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:61d16cba-7218-4c4f-9faa-2ec79ed21614","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7955","original_object":"UniProtKB:O00329"}
{"id":"a9e12d2b-30a1-4260-9fe9-78394508514a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755190","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:28cec942-f177-42c5-aeb0-d20f1a9f9bbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6216","original_object":"UniProtKB:O00222"}
{"id":"f177534f-c772-45b6-913d-62906caa8fea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164885943","predicate":"biolink:affects","object":"NCBIGene:5592","sources":[{"id":"urn:uuid:f6e7d9d7-87b9-4c0d-ad9a-d09679e03e22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12071","original_object":"UniProtKB:Q13976"}
{"id":"817665c1-3a45-407a-89dd-e6cdb00be5ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OK8OFX8K7F","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:81d5e24b-4d84-4e26-9b6f-6ef1bbfab77f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9330","original_object":"UniProtKB:Q08499"}
{"id":"40cbbf9f-a3fc-4990-a2fc-9415d34d57ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18358","predicate":"biolink:affects","object":"NCBIGene:259295","sources":[{"id":"urn:uuid:488523ee-a204-4b14-bee0-cd710095adcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12457","original_object":"UniProtKB:P59543"}
{"id":"fe240635-4431-4eae-8524-a59eebf65192","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GY0F1HMVT","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:ce17674e-965e-4ff9-bccc-1de2beb2cb56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3386","original_object":"UniProtKB:P43088"}
{"id":"c793db2f-1afe-4335-b842-2213e143c856","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3921","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:2b9fbd00-e133-4ab0-8745-e4a20a05ef00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3921","original_object":"UniProtKB:Q63634"}
{"id":"2e288bbf-2550-44a3-a949-53b2b5626779","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2521","predicate":"biolink:affects","object":"NCBIGene:114862","sources":[{"id":"urn:uuid:056c9022-207d-4b4a-a455-a10e6448b19d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2521","original_object":"UniProtKB:Q9EQ60"}
{"id":"13c29048-0694-4e7c-9a6f-3c93fe0caf83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:49d4ba9c-3a6c-440f-8030-a659c15d27ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P30939"}
{"id":"7d89feb7-a221-41fd-907a-2044fe586ce2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44556162","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:09a470d8-0fae-484f-8338-776ca18eb2a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9401","original_object":"UniProtKB:P33981"}
{"id":"62292fb2-2297-42bb-8d4b-e245e0d92d39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679553","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:7bbebd77-e389-4eed-98db-30945cd2a0be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11954","original_object":"UniProtKB:P10826"}
{"id":"677d82d2-7195-4734-bd79-934596863d54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71458575","predicate":"biolink:affects","object":"NCBIGene:23049","sources":[{"id":"urn:uuid:ffe75274-a65b-41ca-aeb3-900ee4cae9eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8827","original_object":"UniProtKB:Q96Q15"}
{"id":"59550a30-5a68-4171-ba68-d41d3e65e6d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:760I9WM792","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:bf0bc395-93fe-4585-a89a-270b9a31031c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3928","original_object":"UniProtKB:P30939"}
{"id":"1aa188db-7f41-4b85-80a9-0fa66e4a2acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50967109","predicate":"biolink:affects","object":"NCBIGene:29994","sources":[{"id":"urn:uuid:e9f04d88-c32d-45a8-b9fb-c3e923482f53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8302","original_object":"UniProtKB:Q9UIF8"}
{"id":"860dde9e-01ec-4c14-bb53-e4e780435198","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:453f0ff2-790f-447c-8f91-aa2a7b6bc78d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9UBN4"}
{"id":"6241ebdb-e583-4ce9-8d00-55e346f5c097","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4085233","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:e11d923a-c940-49e1-b122-ea87978c1e23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10281","original_object":"UniProtKB:Q13507"}
{"id":"0384ce88-c078-4521-bdf9-d1b5fb6a180b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91346","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:8c97b2a8-3e78-45e4-aeaf-8fe7076439fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5921","original_object":"UniProtKB:P31749"}
{"id":"0fd26412-3580-4e10-a668-b24c50775eed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422744","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:2a92e426-3cd3-4b6e-a720-26b8aef5f4d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12932","original_object":"UniProtKB:P23458"}
{"id":"500c28b2-c8c3-4502-bc5f-c373cb727140","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125628","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:85edcd06-26da-4832-bd15-f70f7315aa9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7790","original_object":"UniProtKB:O14965"}
{"id":"47059c01-329f-40e6-8da2-5197c05cfdf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232976","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:57cbe0b8-27b9-4936-8c8e-616c1b316bbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:30","original_object":"UniProtKB:P08908"}
{"id":"da810432-ab5b-4fbf-9bcf-f0faca934815","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:62cf40ca-1485-4c25-b990-02c61f86c1cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q8WUI4"}
{"id":"7ed839aa-1ddc-4376-a90a-43ba213d0744","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104235","predicate":"biolink:affects","object":"NCBIGene:27346","sources":[{"id":"urn:uuid:f599e763-2d2a-4d51-abc4-fa855b2f739b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6682","original_object":"UniProtKB:Q5BJF2"}
{"id":"c2d29034-a9d9-44e0-a9df-6eb713cfae2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93768","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:fd2b2443-b1f9-4f35-940c-9f67e09d1864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5683","original_object":"UniProtKB:P06213"}
{"id":"8ad47b13-2183-4580-b60a-004684054bfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16469","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:9a23907a-c843-4d00-9a61-3f1cc09add00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1013","original_object":"UniProtKB:P03372"}
{"id":"675bee28-e384-404c-9396-49d5be7b9703","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:77be9b93-c74b-4929-ac96-7a506b9dce65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:O88854"}
{"id":"7c67e735-d2dd-437e-88b1-447acbfadf71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U7AP46TK3Q","predicate":"biolink:affects","object":"NCBIGene:4217","sources":[{"id":"urn:uuid:b7f59e33-e06f-41d9-b5a6-420599f86a93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8076","original_object":"UniProtKB:Q99683"}
{"id":"9d2edd22-64af-43d7-b8aa-240d9a8cff3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6128","predicate":"biolink:affects","object":"NCBIGene:160728","sources":[{"id":"urn:uuid:d9ad2903-3ccc-4d79-80f7-b36a904b0582","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4795","original_object":"UniProtKB:Q8N695"}
{"id":"7cfa9f8e-05bd-4076-bdd0-a5e8a3cdd67e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:1515","sources":[{"id":"urn:uuid:19456727-06d7-4ea1-9de3-e77d08ac0a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:O60911"}
{"id":"a97ef4df-b00a-43b0-8317-764b7e1e5166","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46930997","predicate":"biolink:affects","object":"NCBIGene:596","sources":[{"id":"urn:uuid:4ccc4f64-8fb2-4fcb-9ac4-281b824a5024","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11086","original_object":"UniProtKB:P10415"}
{"id":"393e4e22-fff5-4dde-96f9-94f6326604ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93519","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:ce0afc55-b99a-4368-8bfc-fb7a7e54c19c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:187","original_object":"UniProtKB:P41595"}
{"id":"6c0d8b7b-cfba-4937-a9a0-0eaa4151cf60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2071","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:8e537442-f017-4ba8-8ceb-fc25dff03e51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1376","original_object":"UniProtKB:Q13255"}
{"id":"b4b02e2c-65e0-4f08-9567-9900a7b44ed5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15126552","predicate":"biolink:affects","object":"NCBIGene:1510","sources":[{"id":"urn:uuid:c3c6e7b6-c601-4378-9ffa-a5942e5abe9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6566","original_object":"UniProtKB:P14091"}
{"id":"aa5b3ba0-f7ff-4a7d-8c94-41e7abe32c4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28197","predicate":"biolink:affects","object":"NCBIGene:2103","sources":[{"id":"urn:uuid:d07f9feb-a002-4756-ba96-a2a34536946b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2828","original_object":"UniProtKB:O95718"}
{"id":"71bcd83c-b5a3-4367-b187-610f5e63b6f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131347","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:3952b1fb-444f-47b5-9a8a-3666e5874e16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4065","original_object":"UniProtKB:Q13936"}
{"id":"5402e90d-c69d-48d4-ace8-e2c843901e12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4009","predicate":"biolink:affects","object":"NCBIGene:1138","sources":[{"id":"urn:uuid:7463cf7b-351f-4e66-b3f8-ab6fcbb9ba25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4009","original_object":"UniProtKB:P30532"}
{"id":"63f2e812-8122-40bc-adf0-8a5b76fce957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73297","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:76c97e1b-4060-47f9-8dff-9c8d84952bb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:943","original_object":"UniProtKB:P21918"}
{"id":"417f1ca2-a28f-4cd1-84ba-d1131c6f0f67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9885167","predicate":"biolink:affects","object":"NCBIGene:5328","sources":[{"id":"urn:uuid:163fd76a-5f33-4a51-b262-66465822e154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6543","original_object":"UniProtKB:P00749"}
{"id":"636c0ca0-5805-4980-878c-efb757b83f84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ET9Q0750O6","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:6985f0fd-f0d2-40ea-8ad1-e3e03e963ef9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9944","original_object":"UniProtKB:O00519"}
{"id":"112e8e6c-3207-46f8-b38d-825e56a68ca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122163152","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:17385aa6-b7e3-45ad-b000-a6ec468f9d03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9571","original_object":"UniProtKB:O00329"}
{"id":"7742f69a-863c-4f8c-88be-7493587db947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73286","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:b8eb5b74-9288-462d-8257-326c011ad670","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:422","original_object":"UniProtKB:P30542"}
{"id":"8c0eab64-7aed-4ce6-9e0e-b29a48b85fd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2495","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:bf39f646-5423-4a14-8ed2-89d6e52839fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2495","original_object":"UniProtKB:Q9WTR1"}
{"id":"9cac288e-9498-4069-9aa2-dc50dbe76d7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4RA0KN46E0","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:4c2acc01-087e-4152-9760-2e297c369117","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9246","original_object":"UniProtKB:P29597"}
{"id":"e9e74496-0440-4444-97f7-5ef931642a13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177849","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:7c552a07-08be-4079-9b49-8862dcac6889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10408","original_object":"UniProtKB:P41968"}
{"id":"c63552ab-9151-412c-a257-19ff4e166ce5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129244926","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:ded00687-e258-433a-b3ad-69575e6276b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13902","original_object":"UniProtKB:Q5S007"}
{"id":"95b509ff-9b12-4213-89a6-380ac6739e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:828","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:9f63ea67-1efd-4e32-b5d5-39bf1b4790ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:828","original_object":"UniProtKB:P25025"}
{"id":"459dd230-70b5-44f6-a487-9a34648940b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11301185","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:0fd87a0d-7410-4da4-bd60-93978a3837c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6353","original_object":"UniProtKB:P23385"}
{"id":"9d8e14f7-a033-4e56-b05f-65e7c86839ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RF60GS0DRO","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:a34b0be6-c2f4-4177-a5dc-5eb521b2a5c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11365","original_object":"UniProtKB:P00742"}
{"id":"d284e5e4-8f2d-40df-a666-df2fa33dfdef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0I579CNG0I","predicate":"biolink:affects","object":"NCBIGene:170739","sources":[{"id":"urn:uuid:c851f7ba-445b-4785-be2f-4505e239a288","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2308","original_object":"UniProtKB:O54852"}
{"id":"502ce6d5-894f-41e5-8081-6cd54626cb51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5G1WE425BI","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:d224b68f-f83a-44c7-9a31-7c174e15812d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9993","original_object":"UniProtKB:Q06187"}
{"id":"cede6101-6a87-479a-8ba4-90d685478d11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6923","predicate":"biolink:affects","object":"NCBIGene:1582","sources":[{"id":"urn:uuid:eb8bac73-0d4a-454f-8822-52dcef45fbe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2449","original_object":"UniProtKB:Q9UNU6"}
{"id":"d33776cc-bdd4-4f97-83c8-8478f60e13a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9933831","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:a9b5f091-a0e3-4329-b668-20a78b184702","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1924","original_object":"UniProtKB:P34995"}
{"id":"abe37caa-807a-4791-93c2-3d3be0339a52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141969","predicate":"biolink:affects","object":"UniProtKB:P49356","sources":[{"id":"urn:uuid:1050f1f3-f852-48ba-bdc1-7a877ea62976","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8025","original_object":"UniProtKB:P49356"}
{"id":"2330c737-673f-47a5-8d88-8d879706306e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946093","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:b1ae5126-40ae-4be7-856f-0ec99a43d579","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10598","original_object":"UniProtKB:P48736"}
{"id":"2689cdc6-ce34-4ead-a457-7e08d96c6350","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:7433743","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:b10adcfd-e92d-4c94-a47d-126b3deb20bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3320","original_object":"UniProtKB:Q99527"}
{"id":"f9767887-932a-4e6d-bfa9-cba415f19adf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134480550","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:b24f2675-392f-4cdc-a18a-6560195135ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12377","original_object":"UniProtKB:P04629"}
{"id":"2008e356-65b8-4df8-8b00-f2cb459a827c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117995570","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:3ad03600-65dd-4e3f-be11-1149ad4689c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9171","original_object":"UniProtKB:P49336"}
{"id":"6e930808-4ab8-47cc-96a7-f6fbe9a06e07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44622850","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:fc04c87b-0171-4fbe-a1e4-5404281205d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7031","original_object":"UniProtKB:Q86X55"}
{"id":"2250b63d-2f97-4e0d-bbe6-bc1a96bafaf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:837","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:683c2150-b3c6-4d0e-8e5d-98e57c342489","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:837","original_object":"UniProtKB:P49682"}
{"id":"8f6cf2f0-f5e3-49bb-9967-c2810a49db6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2834W8D6GK","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:8d320801-d14b-4bd8-b958-c457b5cb2411","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9963","original_object":"UniProtKB:P56817"}
{"id":"73973ae9-e881-4ac4-ba2a-01dcfb843467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8522","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:aacafcea-7460-4c03-adff-e2228860ad66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8522","original_object":"UniProtKB:Q8TCW9"}
{"id":"27cd3c40-82a5-41a4-9463-a8e753a8e41d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145365","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:9ddcd86b-4161-4e56-9007-1ac743b259f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7882","original_object":"UniProtKB:P36888"}
{"id":"95e3eac2-63bc-412b-a2e9-0f974c6ba35b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H4X2M2NN5N","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:aa47bcb0-5444-4326-bbab-a4164aae4efd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9921","original_object":"UniProtKB:P35916"}
{"id":"2c1dab79-e454-48e4-b207-9739d972c764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754997","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:00555379-17be-489c-89b8-403cb83bfc91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:735","original_object":"UniProtKB:P20272"}
{"id":"bfb9c9d2-1761-4f4e-af73-28bc17dc63a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:867466","predicate":"biolink:affects","object":"NCBIGene:107","sources":[{"id":"urn:uuid:7a7dc52c-ec1a-4359-9f70-ad887c5b5895","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10092","original_object":"UniProtKB:Q08828"}
{"id":"cfa8f2c7-08dd-454b-804b-cb6ddcad6321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71952","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:c57a63a3-f5aa-4f09-9843-d2363afc872f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7950","original_object":"UniProtKB:Q13535"}
{"id":"736b9425-b6b6-4ec5-be60-6a2dbad7288f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118110201","predicate":"biolink:affects","object":"NCBIGene:7301","sources":[{"id":"urn:uuid:361af2e3-6734-45f7-9b43-bbbfac482900","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12320","original_object":"UniProtKB:Q06418"}
{"id":"14418fad-1f13-4e21-90b3-2d6634941d20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124916","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:3008d30a-a03f-403a-a05c-00c6c3b71c83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8042","original_object":"UniProtKB:Q13535"}
{"id":"24f3901e-dfb6-4b1d-b077-40351a7ece28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900913","predicate":"biolink:affects","object":"NCBIGene:55589","sources":[{"id":"urn:uuid:c729abcc-38ed-4932-bd13-68b5736d86d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11895","original_object":"UniProtKB:Q9NSY1"}
{"id":"5608e3be-d515-4b92-aaa9-f5f8efde313d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11545181","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:e572aa01-d3d7-4cd2-9c31-b3031e40c67c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2930","original_object":"UniProtKB:P21453"}
{"id":"a376e058-8708-432a-9e1d-3a10fa808732","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95073","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:218dfc80-a74f-4207-a709-966cf5d509f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7010","original_object":"UniProtKB:Q13547"}
{"id":"26e2f4a8-ca24-47b3-b16c-7c420465ae7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56646418","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:c0d99d48-ec99-489d-bf20-262cebf24a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9578","original_object":"UniProtKB:Q9UHD2"}
{"id":"d7da6d01-9cf5-406a-9272-8fbb16ac433a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M7FHF24Q22","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:3c55742d-a162-4bae-8718-e7820b321d06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:195","original_object":"UniProtKB:P41595"}
{"id":"18960672-486e-4487-91c7-52177e720484","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4975","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:b771e922-6bd4-4807-93b8-704d0314a890","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7074","original_object":"UniProtKB:P25021"}
{"id":"aaf2b096-2f51-4a5d-a589-7249d59c58fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45380979","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:e7168f74-f9ec-4ae9-9ef6-0c917bf89386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7874","original_object":"UniProtKB:P06493"}
{"id":"40ad3882-6665-43a0-b5d2-142a170f5700","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925685","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:fbef4f91-662f-47d8-96ed-f7f924688688","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10597","original_object":"UniProtKB:Q14164"}
{"id":"fc99d2e9-47dd-42cf-a824-f406569e72d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V57G6B5I8Z","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:30e322f1-a182-4126-8585-a7987ab5b32b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1215","original_object":"UniProtKB:P35367"}
{"id":"b2e5379b-08d7-4ac4-89c7-345baf38b5d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:eadeb55d-c61b-43ec-9a15-c0b18e7afe7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P32240"}
{"id":"30f8918c-a3f6-4a71-91a5-dc5eb1c7ce5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8502","predicate":"biolink:affects","object":"NCBIGene:5726","sources":[{"id":"urn:uuid:c36ca702-e6ab-47a1-9794-2aae5ca23efb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6650","original_object":"UniProtKB:P59533"}
{"id":"77b8cb48-4997-43dc-88cd-d50428002ae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135018","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:7776ba7e-4a94-4690-84d8-770420dd4ebe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1610","original_object":"UniProtKB:P35372"}
{"id":"0ab33187-22a9-4994-b330-b742255f2616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:1b7da95c-ae65-4055-9570-5d4b436362c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:317","original_object":"UniProtKB:P10980"}
{"id":"06c9c600-9d7d-4697-8764-a8dff571678a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167667","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:5e28adff-cb34-48d1-a735-3c4e56da3bfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:481","original_object":"UniProtKB:P35368"}
{"id":"da1f1650-3918-4933-b7eb-f10f92886cae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:d0f3fa08-000d-450a-a3dd-3e5919dfec13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P11229"}
{"id":"476f42ea-22d7-4906-afc7-14e1aea24ca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:54ea848c-ba31-406a-830c-3fdab6fc8982","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:P30530"}
{"id":"036d6858-0949-452d-b698-42fdd77c8d5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132427685","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:895ea24c-f37f-4e90-a186-2910b294504b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9749","original_object":"UniProtKB:Q13546"}
{"id":"65f046d6-45d2-4d4d-9265-bb2ecef00586","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:a2987499-c29f-4703-b087-48f75ea61c9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q92769"}
{"id":"3e157085-36e2-451a-8370-6f93af1bc4be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494310","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:d7cd8538-de09-4fc3-aed2-45d2b11effed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13481","original_object":"UniProtKB:P0DTC1"}
{"id":"1d496e5e-37ca-4fb9-8ce3-3d38b5f5546d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71272","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:a96a0687-9953-46a9-899f-e046c44bfbb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6316","original_object":"UniProtKB:P27487"}
{"id":"0983b028-0835-4ece-bfde-1ac9b582f7fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25025860","predicate":"biolink:affects","object":"NCBIGene:12209","sources":[{"id":"urn:uuid:96ef7a49-e836-48a9-a238-bdf4bcd69f1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6188","original_object":"UniProtKB:O54798"}
{"id":"5c58ca13-cb87-4b27-9c68-0c79f3c7e4c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13179","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:16429891-5b4b-4a42-8014-4face532567d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13179","original_object":"UniProtKB:P18825"}
{"id":"4264ca8b-13a9-4728-8d8c-9fb233656d69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28304","predicate":"biolink:affects","object":"NCBIGene:462","sources":[{"id":"urn:uuid:a1617784-351f-4504-8a17-ea374fd587f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4214","original_object":"UniProtKB:P01008"}
{"id":"ac856b25-ae14-497d-bdf4-f47a10e5f44b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6113","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:e0a4ad87-aacd-4988-aefd-0007745bb8d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6113","original_object":"UniProtKB:O43603"}
{"id":"68093aae-4fd9-4658-bf6b-3990c29dfacd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13718","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:70d498eb-c186-4aa5-8e94-794ca0d9190d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13718","original_object":"UniProtKB:P07766"}
{"id":"af7e7ca9-e684-45e4-a843-5d249acf9601","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4822","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:2e2f04c9-dda8-4da0-9971-0be087583f2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:148","original_object":"UniProtKB:P14842"}
{"id":"b77b9659-2881-4d05-bc0d-2525b8044908","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:167359","sources":[{"id":"urn:uuid:b74f4c37-5e5c-4e5f-b366-9f85de39f87f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:Q8IY84"}
{"id":"c4539917-42d8-492d-a776-99cbdc54a871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1335","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:7d0d5c7c-c4c0-43b1-9ebd-20f3b5a0a3aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1335","original_object":"UniProtKB:P33032"}
{"id":"45d65052-0194-495d-a129-e090febddab7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60151587","predicate":"biolink:affects","object":"NCBIGene:24925","sources":[{"id":"urn:uuid:92740dba-c13e-48a5-8044-744408ff0fca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12579","original_object":"UniProtKB:P18090"}
{"id":"933d7de2-1d57-44ee-983c-cb4c283c69a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197140","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:30f6fdf6-64f3-436c-841b-67b108bdc9df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12556","original_object":"UniProtKB:Q9HBA0"}
{"id":"87ee2b0f-eae8-4df0-9f31-7479c5818113","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:349149","sources":[{"id":"urn:uuid:1ea3b47c-6750-4a08-84e7-331af37dbfef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q8NFK1"}
{"id":"a1a1c96f-3f4c-46fa-98ce-dfdaf8db0368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9820261","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:6b6a4f5f-db00-43ff-a811-56395c0a2ccd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:977","original_object":"UniProtKB:P30729"}
{"id":"f3f3adf4-1ff3-4f5c-9d2c-47f7dc904a0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6221","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:d28a9cc8-0af1-45eb-a576-ae72c71f0ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6221","original_object":"UniProtKB:P31421"}
{"id":"bff1cead-ec54-4f35-803b-2284c9870f8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6077765","predicate":"biolink:affects","object":"NCBIGene:11069","sources":[{"id":"urn:uuid:46c19e7e-11ff-480f-8997-ea9ce7233216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7917","original_object":"UniProtKB:Q8WZA2"}
{"id":"f14119ae-c5e5-4b0c-a977-00d79aff25d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71508882","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:96735cd8-d4a9-4627-874e-c67cc334ceee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11630","original_object":"UniProtKB:P0C6U8"}
{"id":"3ef96854-95ce-4116-8c5e-af1b17ab0429","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142077","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:e30541f3-1a69-4cdc-b877-7f0bd75596a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9326","original_object":"UniProtKB:P13945"}
{"id":"8ec87d52-887b-4be3-bfba-f9ead3b61776","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53316721","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:9ec45f38-0383-4632-9b24-49041bb3ba54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4561","original_object":"UniProtKB:P31645"}
{"id":"314b4e52-f4a3-4ca7-b4b8-01f66add6ccb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40953","predicate":"biolink:affects","object":"NCBIGene:6300","sources":[{"id":"urn:uuid:cd16a1ac-85eb-4200-a52c-046aad80a7a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5668","original_object":"UniProtKB:P53778"}
{"id":"f4318773-25df-4d30-a177-a2ef59b12085","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135938","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:df8f4591-9939-4c4b-8067-40d138e28a77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7542","original_object":"UniProtKB:Q92731"}
{"id":"39f65323-7836-45a3-a361-c60d82971eb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:19214","sources":[{"id":"urn:uuid:2022a54e-d43a-434d-b8dd-2225892aac2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:P70263"}
{"id":"c23fc52d-b8a5-4fcb-beb9-78a116bf867c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10111831","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:7b7f1dab-207b-4e46-8871-2dc4750d1f9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1942","original_object":"UniProtKB:P35408"}
{"id":"2f9b4986-e386-49a6-a131-a3dacdf43db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:45b7cfd0-12c5-4a84-bedb-8b639a215ef3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1052","original_object":"UniProtKB:P37231"}
{"id":"105e71eb-5a4c-45e9-beb5-8c9781026c96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1866","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:e7383ac8-23df-4f4f-8010-136fd652b75c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1866","original_object":"UniProtKB:Q8NFJ6"}
{"id":"92b4d510-5540-4005-b336-785ac0456ade","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1997","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:11806dec-3070-4990-8f25-42cb19686895","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1997","original_object":"UniProtKB:Q8TDU9"}
{"id":"88e184d5-d26c-4d17-8f2d-5d7fa077e37a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:86YZ7HCC8V","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:c04a6bc7-be06-4c17-9f0f-e977bf452b7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9432","original_object":"UniProtKB:P52333"}
{"id":"e3df857e-2c5e-4047-bc50-eb0be8b062d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103978","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:e9e6debd-f4d1-4114-aa18-a561a45f9eb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2151","original_object":"UniProtKB:Q9UKP6"}
{"id":"fc991bb6-4d2a-4696-bff0-93cf2bf03b48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:837","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:2c381fe6-80c4-40eb-ab60-3434ba81a0df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:837","original_object":"UniProtKB:P51677"}
{"id":"7e8d8a96-32ec-41dd-b683-44cd4989d209","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6102","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:a30065f5-baec-46ea-a046-a42de228337b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:650","original_object":"UniProtKB:P46663"}
{"id":"5b0e2c10-98e8-4b0e-a787-5dd96a791c10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:b47ff8eb-e29f-4b56-8438-ee51be8d0a8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2406","original_object":"UniProtKB:P48542"}
{"id":"7fbb968a-48ea-4948-9627-e5c0d1be69cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44413322","predicate":"biolink:affects","object":"NCBIGene:10999","sources":[{"id":"urn:uuid:3c8d5727-9907-410f-9738-1384ed798ba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8810","original_object":"UniProtKB:Q6P1M0"}
{"id":"83e10302-613e-42e9-a11c-b219a6b175d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58539171","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:d0b8565f-818d-43da-8318-3202a7100e09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8073","original_object":"UniProtKB:Q5S007"}
{"id":"fad367ca-aa95-4229-8a3e-af69a328275e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:a1811b98-05f7-4e7f-a912-3c6b0d55403a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:Q62805"}
{"id":"6eb7220c-9436-4af8-b1c4-279cbbea2deb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51032","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:8df11532-fb6b-40c5-b7ec-d8f725349394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7176","original_object":"UniProtKB:P35367"}
{"id":"4554d646-cd5c-4e6e-abc0-504df64edbeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:77388c79-34fa-493a-973f-d3396f38ed0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P34969"}
{"id":"d8adb22c-beff-4f35-90c8-5069fc5fb89d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5353264","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:c61a731a-8de3-414d-8d17-0baae0846a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2436","original_object":"UniProtKB:Q13507"}
{"id":"60b467ec-816c-4fba-aa34-3eb22bb670fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16049480","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:a3a7d1ed-6079-4ea1-8fae-90cc487c1ab8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8693","original_object":"UniProtKB:P55055"}
{"id":"88281622-6d4c-446e-beff-42fa1b2e10ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156774920","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:e0435168-6f4b-48ad-9a07-cda5d73869a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12602","original_object":"UniProtKB:P0C6U8"}
{"id":"1f06e860-913c-4320-b8aa-b9034f031733","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J2Q5XQZ64C","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:1f3bac5e-03cc-4558-8f5f-a6b6508b69d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12723","original_object":"UniProtKB:P29597"}
{"id":"9712b5e1-62af-44c7-8617-255ee958f53b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8028","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:71631cac-0784-4b09-9e3a-2ea4f763badb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:209","original_object":"UniProtKB:P31388"}
{"id":"5e8db72b-f56b-441a-b4a1-3f9f277e5dd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136235465","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:1ccf9d0d-e032-463b-bd7c-c7a88447bfa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10332","original_object":"UniProtKB:Q99835"}
{"id":"cea74368-5ecf-4973-a916-95e298bf4ec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165368929","predicate":"biolink:affects","object":"NCBIGene:9088","sources":[{"id":"urn:uuid:b0dd1feb-3e9e-497b-93aa-59fadc9986d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12072","original_object":"UniProtKB:Q99640"}
{"id":"3aa50a45-947b-44a1-b301-eefd1bfed6e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:3bc5fe70-ad97-494b-b048-bc38e3b32dd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q13507"}
{"id":"eca2a174-f9e9-40cc-883d-776443ef0934","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28927","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:0fed1fdd-03e5-4e0d-90fe-a28f88a6770a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:412","original_object":"UniProtKB:P25099"}
{"id":"abd8cc55-00a0-4a2f-9fde-d07630644bbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71308726","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:accb4403-ec67-4f2d-88a1-90a9c32aa8ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:995","original_object":"UniProtKB:P25101"}
{"id":"7dab8289-6c88-472d-a8a6-a61392f2d6c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030528","predicate":"biolink:affects","object":"NCBIGene:3696","sources":[{"id":"urn:uuid:61c055c5-7586-4a0a-9a48-ccdb872790ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10450","original_object":"UniProtKB:P26012"}
{"id":"85684b15-8d1b-43e1-ae05-0e28ab7570c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10204312","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:03f246a3-d57a-44b5-97fb-ba911db4918a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4042","original_object":"UniProtKB:P43119"}
{"id":"74e5ab2c-8095-4610-bb83-565219b14e18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94449","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:62ac2c25-73d9-4c4e-9824-365aba7fbec8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7459","original_object":"UniProtKB:P08173"}
{"id":"b9d720b3-ced7-49cb-8f19-f7f536b50b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:ccf6ac24-c2c3-4762-bd9b-8e187e45a182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9P0L9"}
{"id":"83d23043-5c1c-4039-bef4-fbacc08f0b01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:ec02254b-6a34-4dc3-9384-1a39481bc0a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P35375"}
{"id":"346c7cd8-320b-441c-8e60-b25ae8621821","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154663238","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:ffd2558f-ce64-4313-98da-ebd53a969032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12112","original_object":"UniProtKB:P31751"}
{"id":"aec6477d-db9c-43de-a203-387cce5fdeeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9851134","predicate":"biolink:affects","object":"NCBIGene:837","sources":[{"id":"urn:uuid:ad654f41-30c0-45a1-97ee-134c35d143d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8654","original_object":"UniProtKB:P49662"}
{"id":"53cc8da6-b117-4773-8a28-e713bb8619be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46847262","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:79203c05-1328-4bd6-9933-fa68982e4922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11222","original_object":"UniProtKB:P30542"}
{"id":"f4ecb294-077d-4a3a-82ea-a3996fb3b8be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:a5bf9af6-b913-4639-9c8a-4543a91713e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q9UBN7"}
{"id":"1963f203-c2dc-4e5d-947c-b20318b9119f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44134520","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:37de9fc5-8bf7-43c7-a782-26615d7af748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2257","original_object":"UniProtKB:P35000"}
{"id":"e8fc0f96-389c-4694-8707-ebef7c89ee74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9549299","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:7cb335c9-8f83-4dcb-9ec4-a194837062d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5963","original_object":"UniProtKB:P00533"}
{"id":"60c26a1c-6e6e-43bc-903d-cd5e7438873f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91399","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:f592f690-fd46-4996-8b27-4d76afd26e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5670","original_object":"UniProtKB:P11802"}
{"id":"07946563-0f9a-4aba-bc27-c3149e3139fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9887077","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:702ce69b-a310-4900-b1a8-5497a6f65433","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8868","original_object":"UniProtKB:P41143"}
{"id":"726ec3fb-e4f1-42c0-bb84-5d2eb80a8774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13924","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:d576767d-c386-4efb-817b-571fede8e7d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13924","original_object":"UniProtKB:P47871"}
{"id":"ce529909-bd34-449b-8530-5d859cd19f3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1091852","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:012344b7-c08a-40d2-8004-6d41d811f429","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7809","original_object":"UniProtKB:O60885"}
{"id":"65cebc4f-c04c-4900-a04b-c8fa3ac8699f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132629","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:bcac6619-8133-484c-94ed-97fd6db64152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2104","original_object":"UniProtKB:P25103"}
{"id":"6fe60e7d-d4de-4afe-a1d2-fe685bea2b03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49840","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:98384aa1-5585-4c82-86b5-ccacb67d7250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7806","original_object":"UniProtKB:P11802"}
{"id":"ca8255ec-8947-4ffe-977a-6a38405d0da8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10189","predicate":"biolink:affects","object":"NCBIGene:360","sources":[{"id":"urn:uuid:a9c727a5-02ed-44e4-89f0-199c48e4dbab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10189","original_object":"UniProtKB:Q92482"}
{"id":"f02c0688-396a-47e1-8289-785b476657df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13179","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:9247cd55-ec67-4a10-b265-86342b47272c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13179","original_object":"UniProtKB:P08913"}
{"id":"2f570417-396d-49ef-8818-246cab7e3e9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LG47VG1ID","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:028c2db4-711b-4c0b-86c2-59daef0661d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:380","original_object":"UniProtKB:P30543"}
{"id":"3d531a69-a493-4190-8675-773c24290cf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132290","predicate":"biolink:affects","object":"NCBIGene:3742","sources":[{"id":"urn:uuid:801148c1-9e0e-4186-b711-ce8366dc0bd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2548","original_object":"UniProtKB:P17658"}
{"id":"e28987cc-9c9d-4627-89f2-43f9f09617b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11646823","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:43b48e79-414a-4a0e-aa81-af1646677b2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6409","original_object":"UniProtKB:P31424"}
{"id":"e31d7f65-2425-4766-bcf4-ea56179bfecf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946093","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:f0787883-eae9-42c3-9d62-cabd1ba345f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10598","original_object":"UniProtKB:P42336"}
{"id":"d9597716-22d0-47a2-8ae2-b152c41bc1a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9910222","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:3f2db21e-dddc-4fec-82da-5eb03c8ffdbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6514","original_object":"UniProtKB:P14780"}
{"id":"ea65a759-038b-4505-84d0-064c1063440a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146047124","predicate":"biolink:affects","object":"NCBIGene:201626","sources":[{"id":"urn:uuid:e0720a40-0b74-474e-bc02-fb1dc08f05df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12222","original_object":"UniProtKB:Q6L8Q7"}
{"id":"b7c4c595-39cd-43f4-a142-826a013548df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VKU5X213Q7","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:1e7d30be-4c09-4581-9550-7a914c0820e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7879","original_object":"UniProtKB:P36888"}
{"id":"4691c18f-84f5-4808-80b2-1e9d944b1dae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52911386","predicate":"biolink:affects","object":"NCBIGene:6697","sources":[{"id":"urn:uuid:351b09c7-3651-4e83-b7e2-98a257bc2873","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10130","original_object":"UniProtKB:P35270"}
{"id":"cf6f92c3-dccb-4c7f-aea1-3c08f3c2fc93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46883596","predicate":"biolink:affects","object":"NCBIGene:629","sources":[{"id":"urn:uuid:7626272e-d1b7-462e-a12b-59b0304c2328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8653","original_object":"UniProtKB:P00751"}
{"id":"68177951-b8b9-4aee-8684-650826fac813","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156888508","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:c30410de-5bfd-49d4-bf63-3ad575fd3e3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12867","original_object":"UniProtKB:Q06187"}
{"id":"e07cefec-871b-4f83-af5b-35ce298b3562","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229222","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:3fd3afb1-7daf-487a-a063-a20ab080e004","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7709","original_object":"UniProtKB:Q9Y243"}
{"id":"33f089c7-b127-4497-9f6b-7a825c68e3e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889212","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:55450e02-6f10-4f5f-91b8-2d8e46fcfe96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4260","original_object":"UniProtKB:Q14957"}
{"id":"5464be28-5d94-4c9d-a023-e28103a22824","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1793","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:8789fbfb-0aa9-4a0d-b205-0219c3aaef2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1793","original_object":"UniProtKB:P25961"}
{"id":"d66c04cc-a906-48ee-81c3-503e78f622df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75092","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:c4b10bc5-0506-4b45-87a0-0e5ff473e395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:411","original_object":"UniProtKB:P29274"}
{"id":"ca74a920-d60d-4878-a7f6-dee877b6e315","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177605","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:39810499-5372-4c48-9f05-1a2efff273e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10651","original_object":"UniProtKB:P41145"}
{"id":"e63a7ed9-7651-4455-996c-bd266149743b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90684387","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:580f4184-8a49-48d7-819f-74afec11eff3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8304","original_object":"UniProtKB:O60885"}
{"id":"e0c971f1-e54d-4535-9f8e-f0ef2c634a89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6T4O391P5Y","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:f6489b81-4b8c-4894-bb2a-59d242a528bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8107","original_object":"UniProtKB:P36897"}
{"id":"82027929-7fdb-447a-b10e-6c8c2ef45825","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B61N8R7TDH","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:6fc9686b-dccd-497c-b7e5-f2d1361375c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11072","original_object":"UniProtKB:Q9H3N8"}
{"id":"1fc2958b-9aa6-4149-9feb-52ae5b59dfae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93202","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:ade3c693-adc3-4711-ba22-16f3c0b362eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4256","original_object":"UniProtKB:Q9Y210"}
{"id":"fb7aef24-8cf8-408c-b5d4-a1a18815dcd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:ce14e6e9-a492-42f1-8d7c-a2c5fd1df79b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:Q16288"}
{"id":"3aca3dda-6b1c-423e-8a78-ef1eef7783cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166176970","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:03fc9a29-f65a-4127-b3b3-72647aefd930","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12483","original_object":"UniProtKB:P0DMS8"}
{"id":"419305db-aed7-41cd-b91f-ff51ce1f91af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71766360","predicate":"biolink:affects","object":"NCBIGene:2872","sources":[{"id":"urn:uuid:8dd1a471-8899-444c-919e-14853c4cfe9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12385","original_object":"UniProtKB:Q9HBH9"}
{"id":"eaec94ef-4be9-4a5e-a5af-ea948a621007","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6965","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:c5a8634a-9611-426b-90ce-881989a09df9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:207","original_object":"UniProtKB:P35367"}
{"id":"df9f6704-c1ee-4d4b-a5fa-cf6dd8c24c96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:756","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:a99907e1-160a-4c23-bc5d-03264aed4ac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:756","original_object":"UniProtKB:P51681"}
{"id":"9996660c-57aa-4a30-8acb-edf14d166c19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:81491","sources":[{"id":"urn:uuid:5cc9933d-7324-4878-96e5-9232dee63320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:Q9BZJ6"}
{"id":"a0f3881b-0bc3-4a01-bf05-7ba0a90985e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98Y1I8ZD4M","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:d0704a38-6653-4564-af70-ec7ab8379f7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4082","original_object":"UniProtKB:Q14957"}
{"id":"1651dcf2-0a18-4412-a0e3-ee27f6a5fed4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:6daab37d-95c9-447d-8832-f7c70b194974","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P32300"}
{"id":"05849d4d-64ff-492f-af67-d650d5e475ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11785732","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:176eaad4-398f-4b36-a12c-7295858047eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8589","original_object":"UniProtKB:Q92633"}
{"id":"afa96bc9-5115-4b82-a517-0485471a89f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13142","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:c7c64d96-83a8-476e-b65c-695b426dab92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13142","original_object":"UniProtKB:Q06187"}
{"id":"2b957ce6-b8e8-434c-8816-7f1d209a72f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10454","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:e013ca92-e186-49ec-ae1f-b1216725fc62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:948","original_object":"UniProtKB:P21918"}
{"id":"bbf564b1-58f7-4a2e-8db7-075f3881bd28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RXJ96XL94H","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:b11bd995-ae1b-4ad6-bf1b-ab33c323ff19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9818","original_object":"UniProtKB:P56817"}
{"id":"558e4356-7355-494f-8547-56897eb2978d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57523213","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:2abb7925-da14-409b-a2bf-1cab37181d08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8421","original_object":"UniProtKB:P0DMS8"}
{"id":"792e9699-9581-49f3-a783-b51f801a2cd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EP0P7SHM0U","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:c3ac75cc-fca5-4c21-9f48-9ba4c0512899","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11416","original_object":"UniProtKB:P07949"}
{"id":"f809dd5a-185b-4418-bf06-cd67dc275e47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95074","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:c1518509-8037-4b7f-9431-e6585c361723","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7015","original_object":"UniProtKB:Q96KQ7"}
{"id":"c64329c5-62f6-4521-b770-26732a05132a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UT87RB8I1V","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:bdb39fca-6e80-454d-a758-4c864353768a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12577","original_object":"UniProtKB:P18825"}
{"id":"bebeb28f-aa2c-463f-9926-2b2f25e19b87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3749","predicate":"biolink:affects","object":"NCBIGene:79882","sources":[{"id":"urn:uuid:ed108f36-96c8-46aa-b080-5129b83d022e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9184","original_object":"UniProtKB:Q6PJT7"}
{"id":"e81052fc-2a18-4d63-8a9d-283a3a477ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611894","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:48338192-7571-446b-9ad8-cbd4fb309c2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9997","original_object":"UniProtKB:P42336"}
{"id":"e39ae9c6-f911-471f-a823-54e3ec98d4dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10287730","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:1b1156d0-6579-491b-a44f-d5fa2d3c07b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:77","original_object":"UniProtKB:P28222"}
{"id":"48803f98-9e66-4900-8e68-9f3200a58b1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10204153","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:32fb5f1f-800a-4e5a-adc5-29b8405641cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9136","original_object":"UniProtKB:O43613"}
{"id":"6719b7c3-9dc5-41bf-bc92-1e14e473a04a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118435422","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:553a155f-9b66-49dd-8c68-03302c0d9899","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9943","original_object":"UniProtKB:P56817"}
{"id":"0464cc68-bdcd-441b-bf8e-67ca0c36dc77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93368","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:62ca28db-d41c-4548-9094-0f33e84af5e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:173","original_object":"UniProtKB:P28335"}
{"id":"6cbe5f0a-6530-4b4b-a93a-1a5b46fedac7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50673","predicate":"biolink:affects","object":"NCBIGene:5726","sources":[{"id":"urn:uuid:53c6ee74-78ad-4566-8f21-b9ec641f3bfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6649","original_object":"UniProtKB:P59533"}
{"id":"fecd9b7a-2482-4514-8496-d16938fd6f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233330","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:193b009d-6fc5-4fef-a263-c3360561768c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2335","original_object":"UniProtKB:Q9UGI6"}
{"id":"92e2b2dc-5a95-4b83-bc9b-85da4fb6f233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:e23080f3-4bdd-4ea1-8240-a6e902e4430b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P16388"}
{"id":"7e9268d3-8734-4a65-b8d2-2578155a87ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92386","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:c7c6f8b6-a878-47ce-9aab-7ee187e0785e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:523","original_object":"UniProtKB:P18825"}
{"id":"ad35d30b-6898-4b6a-8693-236b2bbd8667","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:7ab9d0d6-566a-48c0-8810-c538d349de70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:O08726"}
{"id":"3a64c0b7-3711-44b4-bb98-1a6b7a42f40e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9893054","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:aaf2dc47-3074-4f28-9fe1-4898589fa6de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5441","original_object":"UniProtKB:P11229"}
{"id":"326ddf33-1492-4198-90f7-c842b1820103","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1DQI1B52Y","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:e43b6968-6d80-45e9-9e65-13659e4a52e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9429","original_object":"UniProtKB:P31749"}
{"id":"358af050-c5cb-4083-9f69-6e438aca82a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:e68c63da-fea2-4248-80b2-2239420b0298","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P35368"}
{"id":"7605fc66-210a-4119-ada2-1fa9ed0e5e71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Z28M5SX0X","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:a9f0f715-ed08-4193-a5a6-d97aed900547","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10627","original_object":"UniProtKB:P42336"}
{"id":"35e3538f-5428-45fb-9173-6fa97b1e6bb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37537","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:832d55d9-b626-439c-86b4-7a835f9d98b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2341","original_object":"UniProtKB:Q9HBA0"}
{"id":"e9a8c026-9d26-466b-a831-f6335974dcfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:522609","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:08ee7904-b9c3-4499-a5f5-8efd12bda122","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:282","original_object":"UniProtKB:P41595"}
{"id":"1f1880e1-53cc-4a6c-a0e5-a65f6247697d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92833","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:ed0bbcd1-ede1-4e1c-acc1-326e7be8e624","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:49","original_object":"UniProtKB:P08913"}
{"id":"fcd8df04-541b-411f-8baa-87be509aab83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:0f61d490-058a-475b-996c-0609a60691a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:P42345"}
{"id":"97e0fa8b-ba48-4831-b031-46906711ff33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2272","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:9a9768a0-2b43-4ee9-b4a5-ee1cad89efd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2272","original_object":"UniProtKB:P41587"}
{"id":"a9065eb1-0954-4906-a924-468209b979ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17418","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:c39920a3-e363-4341-b900-d1fae12f3546","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1061","original_object":"UniProtKB:O14843"}
{"id":"b12470ed-f06b-4c7c-a880-e5ab09265d11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321166","predicate":"biolink:affects","object":"NCBIGene:6257","sources":[{"id":"urn:uuid:16462b41-25fb-4354-aec3-f407efb952d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10186","original_object":"UniProtKB:P28702"}
{"id":"8e793ef5-444c-41c7-a77d-e0367641886b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10028830","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:0a6848a8-2c69-49dd-b523-234c8b08208e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3932","original_object":"UniProtKB:P13945"}
{"id":"7697ed16-43fb-412c-8bda-604e74923cde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138236","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:8a7501a2-732c-47d3-9ca2-a822b4a61fba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13088","original_object":"UniProtKB:P31749"}
{"id":"f7dca220-19f8-499e-b472-8b3927bdaae6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79090","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:1a4575b3-cc89-47f1-a292-9e9f7d6230a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4307","original_object":"UniProtKB:Q16539"}
{"id":"9d7ec763-ecc6-45bf-a4bc-58f7adb85c63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91352","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:3f2e6af8-b758-4111-878b-94ef9fcf96e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9389","original_object":"UniProtKB:P15056"}
{"id":"447c2586-432b-433e-9f06-c20dfc154443","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180525","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:02a3d24a-1edc-4a2e-949a-56e76b9995c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:462","original_object":"UniProtKB:P0DMS8"}
{"id":"c7417681-4c29-45b5-8c77-9ab6f91d9c30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1811","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:a253527a-bf72-496b-b5da-2ce0530762f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1811","original_object":"UniProtKB:P25961"}
{"id":"a4a87b73-5b17-4586-8886-b9f0f14d7dd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:3760","sources":[{"id":"urn:uuid:d03b7d11-d31d-4b77-be60-55949b7f4df4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P48549"}
{"id":"fb210da7-06c4-4393-a3a0-57e7e76ead09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900912","predicate":"biolink:affects","object":"NCBIGene:8576","sources":[{"id":"urn:uuid:e7dfe5f2-4a43-42a9-8c86-b633e1ad1e40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11893","original_object":"UniProtKB:O75716"}
{"id":"a37ea09c-ae98-4c69-bd9e-e5fe63edde97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11597355","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:4e9b0dc0-703d-4b70-8b8d-6e4608b504e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8869","original_object":"UniProtKB:P41146"}
{"id":"5759a9cd-129c-41c1-8aca-ea23cea80630","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P0FN522VTO","predicate":"biolink:affects","object":"NCBIGene:24182","sources":[{"id":"urn:uuid:e709bbbf-c9b3-4747-b9bc-486b3cca3965","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8374","original_object":"UniProtKB:P35351"}
{"id":"f06830b8-f96a-4d08-a503-4d4f7ef4a6d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:65d2c5b4-4d64-45e4-bb13-dbe123066224","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P21917"}
{"id":"065d6738-8ac9-4813-aa22-1cc466f868b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17276","predicate":"biolink:affects","object":"NCBIGene:1182","sources":[{"id":"urn:uuid:864eb35a-ff8c-455e-90b0-de73daf39c84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4285","original_object":"UniProtKB:P51790"}
{"id":"7030022b-5d5b-419d-ad84-9b5fd69a7d69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78549","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:92313698-1b68-411b-ae89-3e7ad8a8da98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:92","original_object":"UniProtKB:P08908"}
{"id":"a0e4889c-98dd-4a01-af5c-3b025bfddd55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5421918","predicate":"biolink:affects","object":"NCBIGene:171384","sources":[{"id":"urn:uuid:2c815715-c6c6-4156-a154-8f8e17f8470d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13407","original_object":"UniProtKB:Q8R455"}
{"id":"f12d2e90-ce68-4238-9d3b-1d06376061eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68060125","predicate":"biolink:affects","object":"NCBIGene:10298","sources":[{"id":"urn:uuid:605a62d4-7c92-4167-b425-0d977dfec29f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8938","original_object":"UniProtKB:O96013"}
{"id":"4270a421-b979-4344-a122-55aac71c13f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7043","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:97c06327-9523-427d-8f87-8a4e14d109f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7043","original_object":"UniProtKB:P04201"}
{"id":"a42a7b16-5459-4b79-bc44-6edd81f52949","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:3055","sources":[{"id":"urn:uuid:06bab047-5339-4d5e-9f04-d32caa7c839e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P08631"}
{"id":"03423a61-7305-4fbb-8928-2646b669c2b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:29710","sources":[{"id":"urn:uuid:8a112d73-7ee6-4958-ae66-f5ee050a2c5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:O88420"}
{"id":"69a8cae9-eb33-4777-adbd-96108eaafa70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2071","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:e844b73c-afce-4de2-b4bb-1f233b394bda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1376","original_object":"UniProtKB:P23385"}
{"id":"4bb34bd3-6ee5-402c-b530-afd2dc2b6c79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15950844","predicate":"biolink:affects","object":"NCBIGene:158584","sources":[{"id":"urn:uuid:5d2291fa-3fbb-4900-be67-323065812111","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10248","original_object":"UniProtKB:Q6GMR7"}
{"id":"48bca391-e442-4869-b539-2b21e83864a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:85366","sources":[{"id":"urn:uuid:5bddad05-b0a6-4450-9aec-cbad546550bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2351","original_object":"UniProtKB:Q9H1R3"}
{"id":"9203b421-6974-46fd-95f2-a49297778f8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2K59L7G59M","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:5b744fb2-b9c1-48fb-bcfa-4a803f619a20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9728","original_object":"UniProtKB:P48736"}
{"id":"93be4512-629b-4838-a6fe-40f7a23ae049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:3de6bbbe-eb69-417d-8535-3451291487df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:Q16445"}
{"id":"475efa81-9d18-4509-807b-76e7e3b59318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:31b74ac4-e803-42fb-acff-d4f21e6a92fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P08908"}
{"id":"f1f95769-4f50-477c-989e-1ae84ebf173d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:8607850","predicate":"biolink:affects","object":"NCBIGene:84875","sources":[{"id":"urn:uuid:ef14bb26-1248-4dc4-89df-47ea790f9913","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13120","original_object":"UniProtKB:Q53GL7"}
{"id":"29b01efa-35a0-4d86-a201-33de70e2fa10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2191","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:ca33d3fe-2acd-4288-90ab-b6d375c5d5ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2191","original_object":"UniProtKB:Q00788"}
{"id":"e58a9a5a-28ef-4001-9705-8b097e110cdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3083288","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:27160264-e530-4284-9b84-da83478095ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2242","original_object":"UniProtKB:P30559"}
{"id":"f5723d70-0622-44aa-ac1d-4ec55fe049a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94306","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:14a3ecd0-4fc7-4bef-9219-10f1ad186346","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9664","original_object":"UniProtKB:Q13547"}
{"id":"ef88e6f0-2470-4116-8c63-fdec1eaf254f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1479","predicate":"biolink:affects","object":"NCBIGene:17171","sources":[{"id":"urn:uuid:fea5017e-29af-4b78-8866-e156907c2968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1479","original_object":"UniProtKB:P30554"}
{"id":"a210a233-bc1d-4e94-be63-d8caf6b5dd48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11834987","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:713fcedb-6dfb-4438-b564-525f1a48732e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6402","original_object":"UniProtKB:Q8TDD5"}
{"id":"35e9aca3-dd1e-475c-972f-4c326d992e4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VI5LR1EU47","predicate":"biolink:affects","object":"NCBIGene:1135","sources":[{"id":"urn:uuid:0fd81bad-646f-4eaf-a7ae-17c608220e74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9056","original_object":"UniProtKB:Q15822"}
{"id":"d3830e63-3f59-4e74-b782-02417c1c9944","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:642","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:88550132-4184-479a-b8e7-4f3d0883c9d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:642","original_object":"UniProtKB:Q61125"}
{"id":"34e38439-9f74-4714-8422-50194c8a67de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83656","predicate":"biolink:affects","object":"NCBIGene:10131","sources":[{"id":"urn:uuid:cf4119e5-7041-4381-a238-a5c92ea56e55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9261","original_object":"UniProtKB:Q12931"}
{"id":"0b20b1b5-deef-4914-a721-a896086d6fde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135686","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:e3e67b4e-e273-4f99-bff7-748db5e46e4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7471","original_object":"UniProtKB:P35372"}
{"id":"35d08018-ab0c-4d53-a17c-18e06860f6f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10033311","predicate":"biolink:affects","object":"NCBIGene:1508","sources":[{"id":"urn:uuid:23c7a4fa-bd16-4be6-a37b-39d0c1c360af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6534","original_object":"UniProtKB:P07858"}
{"id":"243f5227-78ac-4b1d-aacb-1fa973b36d99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0TJ631J0KP","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:779a8219-c11d-482f-bf1c-c7c1c26de468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8179","original_object":"UniProtKB:Q16539"}
{"id":"b2cce100-7f19-4bea-a145-4e0f3932122f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34946","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:c0d8caab-6c81-4d9b-9c13-6abf90e4b468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1739","original_object":"UniProtKB:Q15077"}
{"id":"0438429e-8b8b-48bd-b59d-d1391714a6f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27690","predicate":"biolink:affects","object":"NCBIGene:71934","sources":[{"id":"urn:uuid:892ff876-34b1-45de-8b04-f93b2929104c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6792","original_object":"UniProtKB:Q9D6N1"}
{"id":"65b38bd0-25f8-4d4a-b00e-4146969ce0b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:7f7c793c-9f57-4c5c-9c89-227a76108bdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P30557"}
{"id":"31752177-ff02-4372-b91c-20eccec9d12d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:754","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:a7b97621-813a-4501-8d0e-8401916b9787","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:754","original_object":"UniProtKB:P32246"}
{"id":"c560b647-7d41-40d9-8468-26eacee15ac7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H32ABL87X4","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:0fb853c3-20d8-4c2c-88b7-ec5c5be15481","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2673","original_object":"UniProtKB:P37231"}
{"id":"547f2516-fdd4-4b3a-9397-981a2e7be72e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HQV4NK9UCS","predicate":"biolink:affects","object":"NCBIGene:8445","sources":[{"id":"urn:uuid:ff3f1f1d-7df2-4e48-b67d-e6dc50e0295c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8127","original_object":"UniProtKB:Q92630"}
{"id":"86bfd7a9-1f8d-4b7a-a69f-6ffdc4523b3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111176","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:fba2b029-59c6-4977-913b-e0c2d270ee3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:950","original_object":"UniProtKB:P61169"}
{"id":"1fa980c7-a50a-4081-a7a6-0714d9175bab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92107","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:70bb0318-7f3c-445b-8428-6a4f4e17df30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3366","original_object":"UniProtKB:P49286"}
{"id":"17e1795b-a362-4874-b66a-5079db31c3b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40021","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:0727928c-be95-4126-bb19-9bc072527333","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2637","original_object":"UniProtKB:P10828"}
{"id":"ab08fb1b-bfe5-4b6a-9437-43f33e4db314","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FMJ6D8Y1B","predicate":"biolink:affects","object":"NCBIGene:8639","sources":[{"id":"urn:uuid:765bbbd2-f22b-4457-85b1-55c95c822c85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9754","original_object":"UniProtKB:Q16853"}
{"id":"8503a5e9-4113-4a4b-9cac-ee46d1643bcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59460354","predicate":"biolink:affects","object":"NCBIGene:9153","sources":[{"id":"urn:uuid:fd27ef22-0954-485e-836a-f8ad5082182c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8485","original_object":"UniProtKB:O43868"}
{"id":"594d62fe-5f6f-4d2a-9253-b53086dd28e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11527","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:cb1866f2-ada9-48a5-9b30-883c75f4ce69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11527","original_object":"UniProtKB:O43614"}
{"id":"6b204ba8-4e1c-4519-b4a3-51a58dec44ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:40845ff5-80ed-4f2d-a872-7cc1120caf8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P32305"}
{"id":"32cd18b9-78a7-4732-8797-be07999befb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868452","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c3e2417a-782a-497b-95d1-1406648d71de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:129","original_object":"UniProtKB:P28221"}
{"id":"2e791d38-7905-44ee-8e4f-7f7f737c6500","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31857","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:bea0a8b5-e597-462e-8c8a-a658674dc082","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10102","original_object":"UniProtKB:P35367"}
{"id":"21bea0ca-9f2a-4132-a43d-cb63eabf1048","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94513","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:085362bb-4fbf-45c9-9e2f-187e8cfe948c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6828","original_object":"UniProtKB:O43570"}
{"id":"b68d7317-bab1-47ad-9bda-94fe8bd96bf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817402","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:71a1286a-98eb-4849-b101-1bb1f29e2055","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1287","original_object":"UniProtKB:Q969F8"}
{"id":"6f30fb5e-24ec-4092-a3b8-0e6df1817aae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98Y1I8ZD4M","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:17d07665-55ac-4cb8-b52c-3d58cb045c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4082","original_object":"UniProtKB:O15399"}
{"id":"f76d1969-36ff-4379-a6b6-6835ad377a77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10568125","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:1a58a4dc-e67a-4ffa-b2e4-05a5c5dbab81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:399","original_object":"UniProtKB:P0DMS8"}
{"id":"34a7d887-2931-4f96-aede-ea7a17246d88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139458","predicate":"biolink:affects","object":"NCBIGene:8871","sources":[{"id":"urn:uuid:a0cc1a0d-74bb-4b25-a66c-8f471f08d1a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12667","original_object":"UniProtKB:O15056"}
{"id":"01d456e3-feec-4945-9809-0df30ab1af15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755095","predicate":"biolink:affects","object":"NCBIGene:6565","sources":[{"id":"urn:uuid:074c704a-0906-477c-81d0-3ce37b13e290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4499","original_object":"UniProtKB:Q16348"}
{"id":"fae9a34b-82dd-4755-9124-ef3c7ad905ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4319","sources":[{"id":"urn:uuid:896f2e7d-ffa4-46e0-b349-105c9f591b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P09238"}
{"id":"42370750-09b3-41c4-8b61-f62a123d3845","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817405","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:336a5ae8-4376-4b74-815e-8174020ecb43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1302","original_object":"UniProtKB:Q99705"}
{"id":"b3e76123-b92c-402c-b122-aee6cdefb69e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81390","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:c47d0e4d-a56a-436b-9d27-dfb6390e1507","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1251","original_object":"UniProtKB:Q9Y5N1"}
{"id":"2003a43a-ce62-4024-9bdd-c719037b9b2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46900258","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:9af6e4ec-f3cd-447e-8b8e-8455add7769b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8550","original_object":"UniProtKB:Q86TI2"}
{"id":"da6427aa-10e1-48ae-b1ed-bb22b3c77888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135697","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:edc84b99-0f03-4ab2-8f18-c709dde6b1ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:210","original_object":"UniProtKB:P28223"}
{"id":"8272b629-4974-4af1-9daf-7b185a78249d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:8913","sources":[{"id":"urn:uuid:961bd457-cfac-4617-a0d8-470c927febfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:O43497"}
{"id":"1ca5bb9b-3e05-4ce9-a377-dd2032c6d6e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44598833","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:1fee86e4-5b33-40ef-8b65-ccc68f658576","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5600","original_object":"UniProtKB:P0DMS8"}
{"id":"5c1bd4e2-0f92-4404-ba84-125ef8f54d4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:1181","sources":[{"id":"urn:uuid:e25a587c-184f-4b69-97a2-1a9759ab60ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:P51788"}
{"id":"07176391-27bb-4889-914e-d9d669bc6354","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185064","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:da634bee-d6de-4c45-a4ec-01d91dcf6cf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1902","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"e51cb65f-df4c-45a6-bbf5-26f7b7e610a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13475","predicate":"biolink:affects","object":"UniProtKB:P0AES4","sources":[{"id":"urn:uuid:7de56da8-b991-4025-8618-edb181fa20bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13475","original_object":"UniProtKB:P0AES4"}
{"id":"94300eef-b54a-4ba5-9ce8-c25ea82429da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2945","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:d25320ef-90a5-46b9-977d-4190a3755a6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2945","original_object":"UniProtKB:Q99788"}
{"id":"53a8a701-25d6-4342-8743-0ecb0dfa381d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437356","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:97cc6082-e777-49f0-90f1-158ee79f85b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4170","original_object":"UniProtKB:Q12879"}
{"id":"5ee35fc0-f079-46c3-8cdd-8696d434defc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754990","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:6b45e6e1-8ce3-4c12-9e89-e6d137f52ed9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:261","original_object":"UniProtKB:P32305"}
{"id":"f4860f1d-d39c-4adb-86bb-7e69b270062f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10082","predicate":"biolink:affects","object":"NCBIGene:209513","sources":[{"id":"urn:uuid:9f94c4e3-02d2-4deb-95f8-216643ca22a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:517","original_object":"UniProtKB:Q5QD15"}
{"id":"611e4c7d-9310-45cb-b2ca-2e3b83b594be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3A189DH42V","predicate":"biolink:affects","object":"NCBIGene:1043","sources":[{"id":"urn:uuid:15ad33a3-a2ce-4c2b-b83e-e584d4065860","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6770","original_object":"UniProtKB:P31358"}
{"id":"5c7d2a5a-5df4-4f43-bdcf-bb87b36a5871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134585358","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:375d5f5f-8169-4fa3-a4f2-e012c4efa130","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:13387","original_object":"UniProtKB:Q9UQD0"}
{"id":"428e3bf2-e3f6-4144-9c85-15fce6093e47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035974","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:ddf915fc-1d2c-415c-a851-680467c7ee09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4243","original_object":"UniProtKB:Q12879"}
{"id":"7d9e7974-1ae3-41aa-a89f-957affac9333","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679552","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:d00ac32a-ed82-479b-af15-47a2b8bf6fab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11952","original_object":"UniProtKB:P0C6U8"}
{"id":"01233441-06cb-4dbc-a117-f094ccc25ae7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63607","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:ce06bbca-4013-4b0c-9f88-dbce5dab515e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10827","original_object":"UniProtKB:P27338"}
{"id":"7d88608a-990f-415a-8686-3253af0303d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9864550","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:78605d9d-1456-48cb-8695-392eaccf808e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4332","original_object":"UniProtKB:Q13224"}
{"id":"2dda4be5-7ad8-4abf-bc39-5431e080de3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:375519","sources":[{"id":"urn:uuid:94045753-a19f-4860-922c-d94c0149d9f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q6PEY0"}
{"id":"53aca2a1-cf42-4dc8-9e9f-001756e92e11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75393","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:8eaf4cb8-f7ed-4583-8bf2-3b0b76710ded","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5290","original_object":"UniProtKB:O75116"}
{"id":"953a2841-5936-47e1-9877-87a3ad9fd1b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2029","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:38f1d6e5-a923-408e-9eb2-a6d840b9569a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2029","original_object":"UniProtKB:P31391"}
{"id":"e83fa6aa-00f9-45a6-9924-332b7e8d5bd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59385","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:4695c13e-e576-4149-87b5-9834c1692b46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6527","original_object":"UniProtKB:P42574"}
{"id":"0a5bdbb9-aa95-4f9f-8c4e-6534bc6aa978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53475435","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:e6818f59-75fa-45d9-b0b1-be511c28d9a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10282","original_object":"UniProtKB:Q13507"}
{"id":"48495fae-0b44-41d0-8f06-b9c0b0d3c904","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BW5QA5GEW7","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:ae941d57-497b-464d-8a31-a9ab97bc7bf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13063","original_object":"UniProtKB:Q09472"}
{"id":"898e33ad-61b0-4db5-93fe-61d73538a15b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:117155","sources":[{"id":"urn:uuid:dddac75e-9e9e-41cf-bb9f-8387e1bfaa92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q96P56"}
{"id":"1d1702ab-660d-4fb4-b3dc-40741a872c49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:119517","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:49c0d884-1408-4232-8f43-3ccdff326a20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2225","original_object":"UniProtKB:P37288"}
{"id":"e9e94035-7bcc-49b1-bef3-497831aa8647","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:74189dee-a57b-487b-b74c-1cc9e689a709","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P35348"}
{"id":"203c7ded-3107-43bd-a334-8ab71c4fce3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10104167","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:731a6ae2-91b2-4a6a-b123-81e1ee6d3f87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6937","original_object":"UniProtKB:P11229"}
{"id":"90de0372-6f34-4928-a15c-76e703fe21b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:721809WQCP","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:fd5d2b00-c8e1-4931-82cf-6f891dd50be5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5263","original_object":"UniProtKB:P05771"}
{"id":"3d983a19-d42e-4233-881e-b79c61f34b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16036927","predicate":"biolink:affects","object":"NCBIGene:18","sources":[{"id":"urn:uuid:11aa4474-1d08-4657-b98c-df97b652cb17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8841","original_object":"UniProtKB:P80404"}
{"id":"44b248bf-ace0-4ae1-a5bb-4fa95a3de564","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10002","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:3d7a389d-d5fb-426e-8c86-a54378718daf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:433","original_object":"UniProtKB:P0DMS8"}
{"id":"78a391a7-df58-4080-924c-ed48bd959b8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311224","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:4c078b7e-5f81-4912-8237-a1e4aeb15fad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1937","original_object":"UniProtKB:P34980"}
{"id":"07f64627-5a7d-47f3-b14d-e4f6d595c6f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:128440","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:9480c6ce-5b65-46ed-8e92-ef628ca5f0b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2701","original_object":"UniProtKB:P37231"}
{"id":"30cadb51-9be9-46d3-974b-fcb0b91a903e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16978","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:02a02129-6791-4394-b99e-e97a8f934ff7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3354","original_object":"UniProtKB:P25090"}
{"id":"72958257-a6e7-4cab-8514-50ffc43e614a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24780383","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:e2ea6733-1015-40ff-97df-5954fafd1f0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5616","original_object":"UniProtKB:P30542"}
{"id":"8bef20ca-ddc4-45d2-9e4e-027987d31ddd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754990","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:1d0eccc1-8ab6-460a-8548-3e2fe0830932","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:261","original_object":"UniProtKB:P47898"}
{"id":"7df9d2aa-830a-47b9-874d-d8d4f5c4fa35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3127","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:274c1d7a-86bf-4e6e-a28d-1b9fca298cdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7129","original_object":"UniProtKB:P08588"}
{"id":"53c85224-865d-47ca-a19c-f7ecb4eaab8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699448","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:5dde5f04-9736-4c41-828c-9d250f237bb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11145","original_object":"UniProtKB:Q9NRA0"}
{"id":"fb137f02-e924-4c5f-9363-3b234fe769f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:2900","sources":[{"id":"urn:uuid:71f09ea1-c5fa-4855-aa31-4d1725ea2016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4075","original_object":"UniProtKB:Q16099"}
{"id":"69c009d9-2c41-4fb3-8094-36baada30938","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2663","predicate":"biolink:affects","object":"NCBIGene:3743","sources":[{"id":"urn:uuid:558ccb2d-786c-463b-9270-7f3463c2f952","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2566","original_object":"UniProtKB:Q96RP8"}
{"id":"643cfe01-61a3-461b-bb24-c3839eb8cde8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40520","predicate":"biolink:affects","object":"NCBIGene:384","sources":[{"id":"urn:uuid:c80816c0-17b3-4d27-ab5a-127ff89c5b5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5107","original_object":"UniProtKB:P78540"}
{"id":"fd086e08-1cd6-4f87-b7a8-3284673b2639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46182736","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:c4f81614-b59e-44fc-9ab4-4887b25ade1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6323","original_object":"UniProtKB:P31421"}
{"id":"054e1aa0-e311-4ac7-96d3-a8df8189cecc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7465","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:136631c0-1383-4fba-83d7-e425480f8633","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1639","original_object":"UniProtKB:P33534"}
{"id":"5d91642b-c868-4cf7-a888-e104cb026b0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117977934","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:f3085f5d-2cae-4c93-8805-758a49d561ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10268","original_object":"UniProtKB:P55085"}
{"id":"80dd91ca-af40-444a-a529-96e4a79530c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91357","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:818c65bb-ed81-4a74-8d10-ec044d7cd603","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8007","original_object":"UniProtKB:O15530"}
{"id":"29d649de-66cc-4aed-b9b6-a42299304292","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755222","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:d6678c28-e747-4481-a13c-02482cc36a0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6442","original_object":"UniProtKB:P41594"}
{"id":"dadb8b85-1a22-41da-a534-f5cf2c0a2bac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:c1671477-d41f-438e-a4f4-789995e24661","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:O75311"}
{"id":"0d0539d8-7437-4664-ac80-66abd3f0d2d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7035","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:f48b8d40-696c-4500-b54b-58e02736d777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7035","original_object":"UniProtKB:Q92831"}
{"id":"dc665e08-f418-4637-96d0-8fb8782383c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321156","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:343d7656-9d87-4515-ae59-7646a7cd8d14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10148","original_object":"UniProtKB:O60674"}
{"id":"5bbf0484-fe57-4543-9d35-94ffac06a965","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16325","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:02a1d50c-8da2-4d3b-b215-06f9f1b092f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:611","original_object":"UniProtKB:Q8TDU6"}
{"id":"7782f421-9af4-4bb5-a20a-16e531bf99a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91439","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:5937bc46-d46e-4118-8e4e-cc8a35bedce9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8006","original_object":"UniProtKB:O14757"}
{"id":"e9d3733f-fee9-4c96-a947-d23eb94f7b4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134846","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:c47c0a72-e129-4710-900a-35125680a546","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:306","original_object":"UniProtKB:P20309"}
{"id":"b74db031-0b92-4db4-8922-aa936a66c330","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:25689","sources":[{"id":"urn:uuid:888314ff-cd9d-4930-82ee-f16a9dface4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P35364"}
{"id":"0d76f104-515a-4cd6-be09-59b17b5426d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T8B02RAU3C","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:db8f61ac-3f27-4c0b-bc0e-2c3853300a50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9062","original_object":"UniProtKB:Q99572"}
{"id":"421bb5a8-25af-4442-ab85-8c98851ff9f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231412","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:7c26fef9-bafd-43b6-8dde-57bc0294c517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9222","original_object":"UniProtKB:P00533"}
{"id":"7fac3dd2-60c5-47f3-810f-a226a88fcd5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6191","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:f0a2515b-583d-4efe-ac88-6757746a9676","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6191","original_object":"UniProtKB:P32247"}
{"id":"03683da3-61a2-4d5b-a31e-677d8526b753","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I0BGE6P6I6","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:8d465785-3888-4ada-96ac-41edb395c493","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11332","original_object":"UniProtKB:P0DTC2"}
{"id":"ac37649c-dc9d-4a52-8494-90583ec5ca37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2981","predicate":"biolink:affects","object":"NCBIGene:214763","sources":[{"id":"urn:uuid:57155399-9334-4122-9b51-9ba024f21a92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13076","original_object":"UniProtKB:Q8C6L5"}
{"id":"d3bd7e12-dd20-4c94-9053-929ee8196c01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:acdfed16-41e2-4943-b9b1-9cd3a7701299","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P06239"}
{"id":"03e89337-48cd-49f5-b39c-5b56b8c87169","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NT43S9BKJ2","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:d93375fa-feb2-402e-ab95-579fe843518e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8870","original_object":"UniProtKB:P35372"}
{"id":"bc3a047f-3aec-4286-a69c-b7f4dcf29cd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11650985","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:8cea73b2-26ce-43e3-ac83-81255233810b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5621","original_object":"UniProtKB:Q62967"}
{"id":"478ca7dc-7df4-4721-94d4-b4b1740f9bc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8620","predicate":"biolink:affects","object":"UniProtKB:P0DPD6","sources":[{"id":"urn:uuid:d2b69128-7046-4841-a178-2b9b45a46684","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8620","original_object":"UniProtKB:P0DPD6"}
{"id":"69b5e50e-8323-4369-b0ac-b663273c5f69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70702462","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:d558585d-a723-46e0-9d59-cde568c2863c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6392","original_object":"UniProtKB:P23385"}
{"id":"e36f4b67-cd29-4773-84ad-3f6a90fb7489","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:22067","sources":[{"id":"urn:uuid:504be1b6-3c56-43cf-8de5-1f8f21a5121c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9QX29"}
{"id":"7386413f-db26-40c1-9233-8eab9aae436b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T35FOR92W2","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:b8dcedfe-6a99-49a9-a135-107efb76558f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6434","original_object":"UniProtKB:P31424"}
{"id":"13267fb6-1084-4b24-858f-c474ef115528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44126037","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:981a38d2-6792-4001-815f-191b6e82937d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5905","original_object":"UniProtKB:Q9H244"}
{"id":"0c045025-2e25-4f34-a80c-6502679552ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S3OPE9IA3Q","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:83aa8097-a80d-4315-aae8-334e9fa3cda0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9788","original_object":"UniProtKB:P11362"}
{"id":"0e06336a-e9c5-4188-867a-ff7c77171768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156371488","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:fdff6e02-bb98-4c1b-8f83-b6c916eb9b4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12389","original_object":"UniProtKB:P04629"}
{"id":"405059d1-e2a4-4a44-a5f3-6eec3a4f0d8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:e9e4910b-2adb-466f-8116-a5f6212cea96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:Q14831"}
{"id":"f48d2325-6eb2-4201-a19e-a00223ecbf8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9915756","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:3f642122-2bdc-440c-a9de-0180128217d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:904","original_object":"UniProtKB:P30553"}
{"id":"6cc11697-eb05-4bb6-9628-481d8446934c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2047","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:fe0cb0ba-28a8-4321-8414-404cd68ff3ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2047","original_object":"UniProtKB:P30938"}
{"id":"ac7b3220-eeee-4102-8e2d-6e363bda0572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73284","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:f269d7de-74d8-40eb-9833-9607be6a2b88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:377","original_object":"UniProtKB:P25099"}
{"id":"d9c9ad59-7825-4946-847e-ac8147b20aec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:3d3eace8-bcd2-409b-b8ec-e60a7f8b25e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:P37023"}
{"id":"706f9809-f95e-4ebb-a6b3-0b5e16a22fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:6ab25083-712d-4ef1-85ee-cee1e5b78f08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P28221"}
{"id":"85f47b8b-ab2b-4fe5-b3c0-3a1f709ff7f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81559","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:3464552d-7eac-48fb-812e-132638e1c4b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3333","original_object":"UniProtKB:Q99788"}
{"id":"8137e25e-7734-4a8d-a915-73fc966dc79f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:7c75b5ec-6f33-4fb9-a20c-1643020825d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:Q13639"}
{"id":"5a5d284a-7ffb-4f12-a537-a0fe7cd570c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1522","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:44319f2a-5e42-4aed-93a2-c209e3fbfdad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1522","original_object":"UniProtKB:Q63634"}
{"id":"151aed3b-df59-4494-9c11-47ee48a41864","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9098","predicate":"biolink:affects","object":"NCBIGene:2022","sources":[{"id":"urn:uuid:25c0177d-8c1e-4c03-b68a-37ffc288c2e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9098","original_object":"UniProtKB:P17813"}
{"id":"5a6d9739-fd72-48cc-9f21-9bd2271bf735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3269393","predicate":"biolink:affects","object":"NCBIGene:3172","sources":[{"id":"urn:uuid:b427ed40-85de-4128-929a-47b1e7f084df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6695","original_object":"UniProtKB:P41235"}
{"id":"c1bf0ac3-289b-443c-abfb-2fad69260f33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88358","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:4ccb7f5e-e75b-405f-b2af-7d616fc9ac00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1731","original_object":"UniProtKB:Q15077"}
{"id":"dc42760f-89b0-4e4f-ba7b-418631694cbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:4b098e7e-28b9-49dc-97c8-d1565a96d12d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P50406"}
{"id":"fd704d0e-c7f8-4629-8896-20fa1055da1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3215","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:d79b8fca-e608-49f3-a5a0-5685cc056972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2397","original_object":"UniProtKB:P22460"}
{"id":"ba79caa2-84e0-423f-841f-2dd56e6248b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:94168F9W1D","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:71d0706b-cdfa-4eb7-aa76-5e3082602b12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2089","original_object":"UniProtKB:P29371"}
{"id":"e8176d49-8cb5-4ff6-a239-22577a785aab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91351","predicate":"biolink:affects","object":"NCBIGene:5260","sources":[{"id":"urn:uuid:b3aa6c29-2077-4bda-935b-6548fcf75a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8204","original_object":"UniProtKB:Q16816"}
{"id":"7ec34252-4342-4e6e-b22c-f8a9694b03ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:6b99ca10-d36a-4cdf-b829-4d0960d0f8a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P11229"}
{"id":"b5f05fb1-6b78-4d97-bc6f-253c963cd6be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3897","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:a003f227-a736-4123-822f-8bd0f4744601","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3897","original_object":"UniProtKB:O88626"}
{"id":"a588c198-993f-4d10-97d0-7efd3cfbc4f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5855","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:ccb774f6-3166-4716-934b-ba7a4c7a5389","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2713","original_object":"UniProtKB:P23219"}
{"id":"1272ad8f-bee6-42c9-8855-5ef578153c67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SC4RYG0M76","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:1428b49b-176f-4ba8-baf4-3de520f73fc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12172","original_object":"UniProtKB:Q96P20"}
{"id":"40e9c719-57f8-4b3a-a228-1b2e237f03a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108103","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:dd863713-ba92-4c8c-ba2d-8a712cd20cb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3081","original_object":"UniProtKB:Q02769"}
{"id":"58575bd7-43e9-49c3-a030-a67ea0d984f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164753116","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:8f8687c9-0ce0-47df-b41a-af3d3dc803e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13320","original_object":"UniProtKB:O14744"}
{"id":"9025fd37-a8fa-480e-9697-783c8a957d34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10046145","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4870ab4a-5e21-428e-b882-f22340b56816","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5610","original_object":"UniProtKB:P0DMS8"}
{"id":"26cd5b7f-35aa-4171-850b-d58c94dc3d58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:769","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:03105066-ba4d-4ad9-85e5-7b3768abc443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:769","original_object":"UniProtKB:P41597"}
{"id":"3f4c9368-508f-4ab3-bc24-bc93226b685a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:abf5937c-fa4f-4956-a7d0-f9c41857e7cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P28222"}
{"id":"8e12db79-2a76-45c0-a483-3fe8229acf1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53347902","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:6daaf287-3588-44eb-b0d3-c69e0d790845","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7666","original_object":"UniProtKB:P51787"}
{"id":"bc8f5f89-4d1b-4374-af14-c3c130066ea7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9321","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:165d7a1d-8a73-46ab-baa1-ce82601fdfed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9321","original_object":"UniProtKB:Q9HBX9"}
{"id":"eb28e62d-1b14-4351-bae0-4f33258b2b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439091","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:3a558921-f276-42d5-9f99-749ca79bfde3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5606","original_object":"UniProtKB:P29274"}
{"id":"80d03d3b-7160-4ce6-b77c-10bb7ddaff78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28130","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:49174fc9-2480-4aa1-84ae-b60dbc64782c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1876","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"b0fbceb8-58ce-46bb-8dd6-d7428eccc596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755094","predicate":"biolink:affects","object":"NCBIGene:6564","sources":[{"id":"urn:uuid:8b87514a-cf0d-47d3-ab34-5d2fde23bd9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4498","original_object":"UniProtKB:P46059"}
{"id":"40fc5db3-6e40-4d96-8792-96edffc65043","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926513","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:79dcc659-1cbf-4e01-93fc-66c0735bd6b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8161","original_object":"UniProtKB:P49760"}
{"id":"581843b0-4922-493f-9a8f-374789b1f23f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:680d3324-ed2a-401e-87ef-865c50ea7c6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P32745"}
{"id":"bfe233c4-6b5a-4c22-8503-27a2ac50a2b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:9ac27806-ca91-4d7c-a437-5de5a368bd01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P31388"}
{"id":"393ba289-029a-4c3f-96fe-709f06c0e96e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:f99120a4-a1d4-4b4c-9d8a-fabdb732b4fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:P15388"}
{"id":"d6dfcb21-4014-4769-a8b0-af16c5f9387d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6109","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:2e6352c3-91d7-4cf2-ad83-6e08eae7fe19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6109","original_object":"UniProtKB:P47211"}
{"id":"b38526f5-7ec7-48b4-b81f-e45eddb760e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755224","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:9147fd64-a02e-4d1f-a872-41bfad1a5ff8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6480","original_object":"UniProtKB:Q99527"}
{"id":"32d45dc6-a81a-41f8-a62b-ad3b8e022877","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:ff59dfa0-4c65-4248-83e9-216f756de99f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P18089"}
{"id":"a0846cfc-c442-471e-937e-532a87eb5d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:08ef34ce-1f37-4b06-984d-5b13697da71f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P43117"}
{"id":"2a6ac1ab-64be-4b0e-9e51-b6481327d286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10168249","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:570c2457-6a9b-4085-8574-c46314eae2c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4250","original_object":"UniProtKB:P39086"}
{"id":"0b5ad360-537e-4adc-993f-85a5000dd335","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31981","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:371ec0e6-dc19-47b1-a7f8-5eb61dc7f1ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9216","original_object":"UniProtKB:P21728"}
{"id":"c5ef3549-0341-4705-9c81-533b90495e01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40629","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:8ac339f2-9fa4-499d-b9ac-8d1e7618fc95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7643","original_object":"UniProtKB:P00533"}
{"id":"e3556a9d-945c-490b-8d7a-e90cea9163e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137796782","predicate":"biolink:affects","object":"NCBIGene:47","sources":[{"id":"urn:uuid:8fa48388-b5ab-485b-b327-ede352a61c93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12854","original_object":"UniProtKB:P53396"}
{"id":"2a1dbdbf-3d49-4b7e-b5ac-ca77df597a3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:2602f292-4d3d-4def-bc04-4998e33eb220","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:P21554"}
{"id":"9b1d1c13-173f-4a98-97cd-ab6c841b1199","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133397","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:d2a54d81-ee0a-426f-a827-2f3587638f21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6021","original_object":"UniProtKB:P09619"}
{"id":"5ffab96a-ac77-41c5-8a9d-0b1dc8543e00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1339","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:607cdb82-f7cc-461a-8f30-62068dfd91d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1339","original_object":"UniProtKB:P32245"}
{"id":"b69d577e-3a74-4be6-8163-6f137b226f16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:13a7bbcc-31d3-419c-b72b-a2484b71862f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P35367"}
{"id":"67b131d6-419a-454e-9f6b-e826122df15e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2610","predicate":"biolink:affects","object":"NCBIGene:170739","sources":[{"id":"urn:uuid:83551d6f-5168-4a29-8656-fff8ae68a639","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2610","original_object":"UniProtKB:O54852"}
{"id":"c2fe4b50-613e-4479-94e3-6fc7a1745e07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56646218","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:aa44ac5b-e303-46d6-bc8e-b1e933e97095","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9580","original_object":"UniProtKB:Q9UHD2"}
{"id":"58f43228-f97e-4049-aa44-663a98500e39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130961","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:64bdae57-4320-4a1b-be80-e2af0ba126f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2005","original_object":"UniProtKB:P30874"}
{"id":"be0c7a5c-a382-43e6-92c4-76f9f021b689","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9738","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:c47e19d5-98f2-4b88-ad4a-f499f4f1064d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7317","original_object":"UniProtKB:Q01959"}
{"id":"934baf20-2e67-4beb-8384-8f9670034179","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023738","predicate":"biolink:affects","object":"NCBIGene:6197","sources":[{"id":"urn:uuid:0e011278-578b-438f-9602-6f0189277889","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8038","original_object":"UniProtKB:P51812"}
{"id":"decb3f10-4bcf-47d4-a0b7-655831804110","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131152","predicate":"biolink:affects","object":"NCBIGene:7403","sources":[{"id":"urn:uuid:747b28bc-389d-43f2-906e-852d219ed10a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7027","original_object":"UniProtKB:O15550"}
{"id":"da4fa380-a38b-4010-b563-9b88f2a4ee25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8496","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:c6413d9f-374a-435d-ad3f-1335914a0a81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8496","original_object":"UniProtKB:P25025"}
{"id":"4336c81d-cb12-41c4-bb70-af1a4772dd3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:5d834eec-e7ac-4e9a-a360-d5e5500b54cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P56373"}
{"id":"7926effa-dbf3-4cbf-b199-e9ce90efe163","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67WJC4Y2QY","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:67b84d53-fb5b-4401-a1a8-ca60ec777dac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:163","original_object":"UniProtKB:P08909"}
{"id":"7a2b835c-4759-471b-89dd-8e085de7fa1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46908026","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:2046e92a-715b-4d38-a17d-83149deeab50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8249","original_object":"UniProtKB:Q06187"}
{"id":"4eeb3948-2ae4-49f5-bc0e-3b6d7658fc7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2215","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:23604f48-3b7c-435e-b5c2-4856681aebf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2215","original_object":"UniProtKB:P30518"}
{"id":"2aa98229-62dd-4660-bcf7-4b8082751eba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:0ef030d3-4c92-4c09-815b-fbd78b8e250c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P48169"}
{"id":"d03c46ce-b58c-4eaf-b3cd-010c5c34945b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5172896","predicate":"biolink:affects","object":"NCBIGene:952","sources":[{"id":"urn:uuid:68ca539d-04a3-4779-ac43-9b849317cf85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12111","original_object":"UniProtKB:P28907"}
{"id":"5be4ae4b-ea93-46cb-886a-734e8aff356d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AIQ4OWD0RA","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:b14214b8-4cbd-4b84-b0de-8c72c2b503f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8527","original_object":"UniProtKB:P42336"}
{"id":"0563de12-0b26-4781-9788-eb9dce06096d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2N9Q4C7WMT","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:c57d78ea-ffc5-4a12-aa19-629fc413e682","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4066","original_object":"UniProtKB:Q13224"}
{"id":"55b1093b-dbd1-4c66-93a2-1b9a0607e5f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:ac15ad1c-307e-4f9c-ab9f-216ac67cd96d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P35561"}
{"id":"f02f7881-cb06-4189-b4cd-fddbf4114679","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR9ZYH80Z8","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:73575abd-7fd9-41fa-ab38-ef813e1f6e95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9787","original_object":"UniProtKB:P11362"}
{"id":"e2e88f47-cdfd-4afd-8ba7-46d45b1d23ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46906624","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:7e8b5e1b-9fe1-4201-8c79-0122ceef0267","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8207","original_object":"UniProtKB:Q9UM73"}
{"id":"41ecc9b5-8570-444f-84c9-e94708b7db50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25122902","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:7af85cca-7613-472b-92fe-91bfb2d019ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6568","original_object":"UniProtKB:P39900"}
{"id":"2202062f-dcfd-4b8e-a145-aea1ca41c871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44581765","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:388b9791-8bf7-44ba-ab71-bf125b972ab1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8644","original_object":"UniProtKB:P08069"}
{"id":"a37c18ef-9780-4d2b-973a-350dfc351a8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T678746713","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:14463edd-f1de-469b-a357-c21f6264dfcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9174","original_object":"UniProtKB:P08581"}
{"id":"d8c57282-8f16-4634-8c83-064748f2048b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134163708","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:d1f307d3-932d-4cf6-957e-73a85cf051e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10233","original_object":"UniProtKB:P48736"}
{"id":"d51bbbb9-5dc5-4382-bdac-e73bba415b0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:78956","sources":[{"id":"urn:uuid:2bae3af5-5f30-4ec6-9281-3eef903cef84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:O08562"}
{"id":"72505c17-9dc9-4541-96a5-eaa7e7038833","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8205","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:0487df04-d2c5-47e7-a117-84a1407fb37f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4286","original_object":"UniProtKB:P23416"}
{"id":"d0686394-47a7-4dd6-a1a2-c6d8b8794786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YS6K7Q8UP4","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:6065cfa5-1774-4fac-9fee-696342593c1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:267","original_object":"UniProtKB:P31388"}
{"id":"fdfc3b7d-cd21-4c36-9f13-ac4f67851908","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:40e553ab-fc5a-4a6c-b50c-aceb29acac16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q92769"}
{"id":"e479bd76-17b1-4bae-b475-859a26156e3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1294","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:629c09a8-d148-43ef-999c-65c0e70626da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1294","original_object":"UniProtKB:Q99705"}
{"id":"42ef48c0-c9ec-45df-86e2-f130f8788cd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890547","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:3830568c-8e87-4526-ab1f-4a033bb7f00c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:490","original_object":"UniProtKB:P35348"}
{"id":"d79be686-39d9-42b2-a92c-57061ddd051f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:174690","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:1ac6b5d3-298e-41a0-a914-2a21d0eecca1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12582","original_object":"UniProtKB:P08588"}
{"id":"9523f848-ad94-40b0-a548-bc7390bd30b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:aa4a0cca-a35e-4c97-8cc4-4b3000ded847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P28223"}
{"id":"82d491fc-1be0-40c9-a72f-d906e6ac62bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73333976","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:c4386557-6aff-4de6-b21c-bcf987a5113b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9811","original_object":"UniProtKB:P49841"}
{"id":"11e61d39-d021-4c0d-88e6-51f26b8fc400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9905972","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:8d729770-0406-46c8-8286-0282059562e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:249","original_object":"UniProtKB:Q13639"}
{"id":"661adab6-e04b-4b53-9a4e-04dec92854e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2742550","predicate":"biolink:affects","object":"NCBIGene:66026","sources":[{"id":"urn:uuid:b56a61e7-4583-415d-be9b-c40124fa0b3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4213","original_object":"UniProtKB:Q9ERZ8"}
{"id":"06fde63d-5969-4fc4-ac25-5e03bcba19ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53391766","predicate":"biolink:affects","object":"NCBIGene:81672","sources":[{"id":"urn:uuid:2c24c577-33a3-4f24-9a59-251abc51d58a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6217","original_object":"UniProtKB:P35400"}
{"id":"1882f426-8f58-467e-a327-6f906282d20c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679553","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:38c2d8ec-06a7-46f9-afbe-0ffe7fea0a17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11954","original_object":"UniProtKB:P10276"}
{"id":"49b5552a-7ab0-41c2-9b46-845480c32600","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61076","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:241d6b0a-d64d-416a-b77c-3d1ea3348f64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7496","original_object":"UniProtKB:Q9UKV0"}
{"id":"570d20d9-10a8-4904-95b6-c5cdb0a5221e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138740335","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:ea78433b-619f-4f1e-9152-bbf0945e12db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12123","original_object":"UniProtKB:Q99685"}
{"id":"b04a1c9c-bf28-4068-bf30-c121d26473b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44274134","predicate":"biolink:affects","object":"NCBIGene:649","sources":[{"id":"urn:uuid:293fd515-7872-4fdd-9702-790d2d9ecca3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8562","original_object":"UniProtKB:P13497"}
{"id":"598b8211-bf67-411c-9c87-94936d3ac3f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:11bd88d5-9c81-4422-9220-d22d024f1d96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P70597"}
{"id":"fe82652e-afc6-4252-8240-ba5edb980a43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2614","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:ac742695-4468-446d-9fb5-e0b6674e8458","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2614","original_object":"UniProtKB:P35499"}
{"id":"3a54eeda-49e5-49a1-b4fe-cc0decddc0bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91832","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:5bbba3af-0a0b-4889-9032-ba30d312c0ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3285","original_object":"UniProtKB:P29274"}
{"id":"2734160a-6289-4c4a-9ea8-e58fb9e3af18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QKC82E736Q","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:c8607142-be02-4450-a554-1ae079dc5efb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1528","original_object":"UniProtKB:P21555"}
{"id":"55a22c49-6d42-4f3b-9bee-8d0cb2636056","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:27364362-d2ef-4a69-a042-a85617ad99ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P08913"}
{"id":"c1c8efea-b86a-4c2c-9d51-1731564fbab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DF5M8SYV7J","predicate":"biolink:affects","object":"NCBIGene:12773","sources":[{"id":"urn:uuid:d5b913be-8f45-4c41-aaf6-ffe874a3c6ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9679","original_object":"UniProtKB:P51680"}
{"id":"421128dc-0fef-4370-a312-a95a60b0fe1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121596187","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:d7f6f398-3a10-4c99-9cdf-82122dc5d4ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11469","original_object":"UniProtKB:Q02127"}
{"id":"eb69a4a8-6148-42ed-af04-6e590f6c643e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143102","predicate":"biolink:affects","object":"NCBIGene:102","sources":[{"id":"urn:uuid:c241b0d8-6865-4e72-9c07-6b6b0d7d64c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9687","original_object":"UniProtKB:O14672"}
{"id":"27522b74-08dc-4baf-8b02-1af5aacf0441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:56843","sources":[{"id":"urn:uuid:910c17fd-c434-40c4-b970-744ac4e35ca1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9JJH7"}
{"id":"9f878217-df22-452e-9dc8-9c8fe4da4958","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LSJ4493RPW","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:703e9f29-0d9e-4139-9841-e51305470f11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5855","original_object":"UniProtKB:P43119"}
{"id":"960070ab-ee3e-40a1-b392-fef1973174e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90295","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:8a3978be-700b-40f5-822d-202d61beb345","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5703","original_object":"UniProtKB:P35968"}
{"id":"dbf70d70-1582-4314-8f06-b7626ae9c450","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5O1LL04GJ3","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:ff95ee85-ee29-4ee0-ac2c-f347842be65a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2355","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"b2e123ee-7f4f-484c-b133-8819d20d8b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:f575638f-ab72-4d2d-bf08-bc3307162738","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:Q60614"}
{"id":"87ac96cb-8090-4c2a-accc-51ba43beee60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1H7RSQ28BJ","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:c7a698a6-0927-4a38-9b52-a34aef658c48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2117","original_object":"UniProtKB:P21452"}
{"id":"998c4ac6-56ad-4289-9d41-57554c9c8e8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4681","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:79fd722c-84a6-4fc6-8230-b1feb5352c74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2604","original_object":"UniProtKB:O95259"}
{"id":"34d34c04-ef0c-404a-8ac4-e1d530d3232e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817473","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:02625f49-9eeb-41d5-8e3d-1a182c809074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6084","original_object":"UniProtKB:O08726"}
{"id":"1255b273-ac0c-4cbb-b971-221085e9fed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1341","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:5557886c-9946-49f7-b5f0-876c67829fc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1341","original_object":"UniProtKB:P33032"}
{"id":"86aba705-204c-4265-9ddc-735378ef40b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9879103","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:51b5359a-4018-4167-bd0e-154fe22393b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6440","original_object":"UniProtKB:P41594"}
{"id":"034b1165-82ba-4f39-9edb-260eae61d4f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553170","predicate":"biolink:affects","object":"NCBIGene:255231","sources":[{"id":"urn:uuid:0357b6de-72fc-40f2-8337-1cf10442f941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10301","original_object":"UniProtKB:Q8IZK6"}
{"id":"dbc0d2ee-912b-4293-9df0-a15bb6422074","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156440741","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:9f29614a-381f-475c-84aa-93df839fe0e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12375","original_object":"UniProtKB:P07333"}
{"id":"59f07508-5f90-4f23-9bae-abb031f5c85f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28927","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:baa6c8c8-1786-46ff-82ef-0b4f59b01b64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:412","original_object":"UniProtKB:P29274"}
{"id":"c4207b1d-3162-43a5-88ca-faf2be7609fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0J8RN2W0HK","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:87ef48eb-babb-482e-9513-f2ca183765d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9962","original_object":"UniProtKB:P10826"}
{"id":"234a35bc-d338-4f33-8b2e-1371235428d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:7efacaa3-652c-4972-af39-f518c9ec2623","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P08173"}
{"id":"ecf70f52-01a4-465f-8256-44f13e8abd49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94506","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:bfd145dc-05de-4081-b924-14e0c222ad4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5932","original_object":"UniProtKB:P06493"}
{"id":"de550d7f-b0c0-4afb-bb47-68aab0804a8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7686S50JAH","predicate":"biolink:affects","object":"NCBIGene:5579","sources":[{"id":"urn:uuid:b1fd0ab2-044b-4e8b-8407-dd8ef24695da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7443","original_object":"UniProtKB:P05771"}
{"id":"1ef58a3d-f37b-4e3e-93b4-b1eea6a1fbb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48723","predicate":"biolink:affects","object":"NCBIGene:56339","sources":[{"id":"urn:uuid:8cf407da-9700-447e-ad57-3d3101bdfcd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13498","original_object":"UniProtKB:Q86U44"}
{"id":"40691d67-72fb-4ad1-abe2-aaec700e9ccf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:827","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:c5c148fb-ec11-44d3-970b-59628b93cea3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:827","original_object":"UniProtKB:P25025"}
{"id":"14a2a38e-b426-4842-9fdb-357dbea8ea35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1040","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:95d275f2-fadc-40aa-8b56-3480059b3bdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1040","original_object":"UniProtKB:P25090"}
{"id":"c6f90041-4a7c-41f6-b70c-e0818c053be6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:26945","predicate":"biolink:affects","object":"NCBIGene:9572","sources":[{"id":"urn:uuid:4fb44d55-7cd2-456e-9ff8-66f5929945bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4349","original_object":"UniProtKB:P20393"}
{"id":"28b47153-f38c-46f9-90df-c76c6ece8865","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:234248D0HH","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:4f58c206-0ce8-41eb-8ca9-05d5185c8bd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9922","original_object":"UniProtKB:P00533"}
{"id":"0a65ea2f-8731-4416-b7df-e33b6456d900","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2372V1TKXK","predicate":"biolink:affects","object":"NCBIGene:3818","sources":[{"id":"urn:uuid:5ef7965b-8181-4c36-91d5-11fbfc4b29bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9094","original_object":"UniProtKB:P03952"}
{"id":"c778f249-10ac-4794-921d-2313ff3d0cf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135261","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:dae5bfc6-5e62-4fb0-b084-71ec57872613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:569","original_object":"UniProtKB:P25962"}
{"id":"2ddc0216-4788-45fc-942e-89d71bb9a13d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R1XBQ6NTFR","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:230ac19e-3025-429d-b952-66c4452fce16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:154","original_object":"UniProtKB:P28223"}
{"id":"208e3a76-8da4-4a17-82eb-125a89cd3ec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34879","predicate":"biolink:affects","object":"NCBIGene:83731","sources":[{"id":"urn:uuid:5ae07f8d-fdaa-468d-a5a6-4089f9728122","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4272","original_object":"UniProtKB:Q62976"}
{"id":"1a80502c-9f2f-4b9f-973e-50635732737c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:8168a3aa-c4bf-428f-91ed-997a7b3c0b07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P14416"}
{"id":"59689d1f-96d5-433f-b6bc-edb28996301c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:8aa78f47-0f17-41ec-bf06-19a1331a898b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:P43115"}
{"id":"b71c2bfa-73cd-4590-b3a1-4097e6d9002a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4854412","predicate":"biolink:affects","object":"NCBIGene:83518","sources":[{"id":"urn:uuid:68e8c270-cf82-497b-9680-3323c10b7d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11837","original_object":"UniProtKB:Q9JHG3"}
{"id":"1e561eb5-3cb3-4113-931f-887aa7783d71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:1137af5c-cd61-4d60-a6b4-0def2cacf578","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:Q8WUI4"}
{"id":"28b76c95-c65f-41b9-9c74-cc05591ce196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35591","predicate":"biolink:affects","object":"NCBIGene:18171","sources":[{"id":"urn:uuid:84e561b5-1cb2-4ffa-a83c-896ab34c8970","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2762","original_object":"UniProtKB:O54915"}
{"id":"483c3498-ffc5-4869-a0c5-fc3ccbc0e459","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:d726638d-6462-443c-9bab-368041df67fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P30938"}
{"id":"53ff6925-ffa1-4bb5-a5d2-b9ce7ece9645","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8600","predicate":"biolink:affects","object":"NCBIGene:217","sources":[{"id":"urn:uuid:cc98dc3c-1275-4c32-9240-9b7e867deb04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6919","original_object":"UniProtKB:P05091"}
{"id":"c8d9d49d-9530-420d-9430-2fe974dbed27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129188688","predicate":"biolink:affects","object":"NCBIGene:221955","sources":[{"id":"urn:uuid:94d2ea3e-2121-4995-8fd2-00a80745f809","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10244","original_object":"UniProtKB:Q8NCG7"}
{"id":"75363310-d2ac-4780-bc04-1092e65a508d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49837564","predicate":"biolink:affects","object":"NCBIGene:4750","sources":[{"id":"urn:uuid:3906848e-f43e-4876-9458-76b335c77af9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8180","original_object":"UniProtKB:Q96PY6"}
{"id":"e4c266b3-56ea-4465-8433-7f60577ee70c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:207659c6-24cf-4993-b2b9-8bfd5b74211e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:Q99571"}
{"id":"f581b035-43df-4709-b0ad-b3d3bfc31472","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41774","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:14cc825b-882b-4d71-b8dd-9f9530b0c50c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1016","original_object":"UniProtKB:P03372"}
{"id":"a1a6c141-f4ad-4597-933a-1c954a8cd138","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13769","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:5fb2bffe-9961-4e88-ae0b-6d748125d6b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13769","original_object":"UniProtKB:P43220"}
{"id":"e4abe85f-bcfb-4edc-918d-f5e8c8161c84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92339","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:ee5cac20-9286-40ca-a4b1-40aa0f820c67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10348","original_object":"UniProtKB:P20272"}
{"id":"642570eb-b2bf-4747-a54c-d0a5159100d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9934746","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:d4c55158-9a04-4ce9-83df-7112fcff9334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11865","original_object":"UniProtKB:P27815"}
{"id":"4cce9d61-5bc1-4499-bc55-d4ca3c0c50e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70773","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:af07da72-23ac-4baf-a1d0-73f0f36b8692","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2461","original_object":"UniProtKB:O35433"}
{"id":"98abfd55-f1c3-4aea-b932-90b90d069eaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2259","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:06b8dadc-411b-4105-bbea-3d5865fe4a0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2259","original_object":"UniProtKB:P32215"}
{"id":"5f067685-748a-4f70-a5a9-3a84e990ab23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8889","predicate":"biolink:affects","object":"NCBIGene:8797","sources":[{"id":"urn:uuid:287ebf9c-0cb1-4d53-a185-09c959d66f62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8889","original_object":"UniProtKB:O00220"}
{"id":"eebd9ddc-27c8-4814-a4a6-08f3f78be2ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:a2de4d9f-eee8-4e42-b2ba-82458c75e78c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:O96017"}
{"id":"e5c182af-1475-4614-88ec-8b3c2c97133b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125640","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f0ea28e9-4d3f-4e13-8f4d-5a72469d51ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:372","original_object":"UniProtKB:P30542"}
{"id":"c57c6a60-f8c1-453f-a9ee-78a64d27d3d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C88817F47Y","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:188036f4-e88e-4b33-9b00-d97e136ee3ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8918","original_object":"UniProtKB:P48736"}
{"id":"f1144f04-5f9d-4171-8bfe-1f427069d31e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132082","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:55786384-4765-48ff-8dd8-890337ed7b28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7007","original_object":"UniProtKB:O15379"}
{"id":"74ca4c06-58bd-42eb-bde6-2ae6db8073c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8652","predicate":"biolink:affects","object":"NCBIGene:12775","sources":[{"id":"urn:uuid:83527484-4678-47e2-857c-8c40562b8160","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8652","original_object":"UniProtKB:P47774"}
{"id":"45734802-0728-4f6c-a87d-4a15c47579f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91357","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:7e7eb87d-4883-4918-8a3f-91e3430b29ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8007","original_object":"UniProtKB:O14757"}
{"id":"816d2b99-017a-4cf8-86bb-b5bf4bc5c809","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:0a8e20cb-c84f-4304-9701-e9c8262ceb19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P28221"}
{"id":"aa931c3e-519b-440d-b30b-3e3b2ade0745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3176","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:6d9176b7-f8dd-4851-97ff-e65f2958299a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6797","original_object":"UniProtKB:P43166"}
{"id":"50b5b9de-2830-449a-899f-5c9514a37c11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867091","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:5b647330-6f63-4a8f-b8e9-4344569f3ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2590","original_object":"UniProtKB:P51787"}
{"id":"74500d40-eaee-4ae7-bcb1-428fac0a1e7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JUP57A8EPZ","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:3b2cf119-4941-4c25-91e4-d719bb23cd9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12716","original_object":"UniProtKB:P03372"}
{"id":"52097914-160e-4ff9-81d0-276e4c94a6cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8426","predicate":"biolink:affects","object":"NCBIGene:5726","sources":[{"id":"urn:uuid:19bc0516-f160-4c28-8830-2a56b84ecd05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4357","original_object":"UniProtKB:P59533"}
{"id":"158bd3af-ead5-4628-bd0c-91d4177b9178","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114175","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:286be449-36ba-4a71-8710-b96a15e417bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5951","original_object":"UniProtKB:P11802"}
{"id":"0dedcb8b-0257-489a-b6ea-390f37c94b3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81529","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:6379f03e-b975-459a-981f-98043eae0ae2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1642","original_object":"UniProtKB:P32300"}
{"id":"399c921e-3279-4b0d-a1e1-048365e063d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44589122","predicate":"biolink:affects","object":"NCBIGene:23945","sources":[{"id":"urn:uuid:ace7fdf7-3a35-4673-826a-1b042b9adb56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11815","original_object":"UniProtKB:O35678"}
{"id":"5a39e3d0-7705-40bd-8ff4-556ec935c781","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92119","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:1b22d925-cd2a-417d-a10f-7e2f17248ded","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5952","original_object":"UniProtKB:P24941"}
{"id":"9861967e-569a-4591-b691-bbc4aaac2c1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44241","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:87af7aea-b252-40b8-86f1-e71235f5c58e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5224","original_object":"UniProtKB:P15538"}
{"id":"0466adfc-424c-48be-a4a2-f4834fecce6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56675928","predicate":"biolink:affects","object":"NCBIGene:5753","sources":[{"id":"urn:uuid:7feb0d33-e830-4806-9803-f5700d35bc06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8186","original_object":"UniProtKB:Q13882"}
{"id":"42c3336c-5fc1-49bb-b102-4762ccb78ce6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030518","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:32815689-9263-471e-9fc9-3c296c25fa0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10420","original_object":"UniProtKB:P10721"}
{"id":"bbd7b7b3-37f3-4f14-8f06-89f93bb1448c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287855","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:e7087fe7-7dd9-4ad3-8cf0-33ae13262c33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6024","original_object":"UniProtKB:P48736"}
{"id":"437f8e3d-9f74-4ace-a145-955d0db95dde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:0c44ad48-1a7b-4208-8d47-ae5f731fd228","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:P36894"}
{"id":"3526ee97-f781-45dd-a6f7-e47dc317970b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9753","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:a95751fe-6c64-4390-9a5d-c19de40cd166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2693","original_object":"UniProtKB:P37231"}
{"id":"3cb30f68-924e-40f3-a85e-ff971ee22e45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3207","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:f1d36f0e-51c9-4a1c-b625-adf4fd125102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7434","original_object":"UniProtKB:P06401"}
{"id":"2b21b5b6-6a36-4796-a74f-278c67da28a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70934541","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:4edd3e31-13d9-404f-8903-b30efa1931ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8939","original_object":"UniProtKB:Q13153"}
{"id":"a6a02e31-e135-405c-bb7c-34930117544e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138502","predicate":"biolink:affects","object":"NCBIGene:2562","sources":[{"id":"urn:uuid:32455bab-8a89-485e-ae21-02c73c897d7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:7336","original_object":"UniProtKB:P28472"}
{"id":"ffe5a2a5-9ed8-4c2d-a4c8-2b35ebba0bec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13805","predicate":"biolink:affects","object":"NCBIGene:2217","sources":[{"id":"urn:uuid:39578b89-858e-4478-b6f1-fcdf6496ac5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13805","original_object":"UniProtKB:P55899"}
{"id":"aa307a97-1858-4f69-8677-0cab74a5ac34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183945","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:cf7c62f0-1a6d-4a25-93e3-d4fb64a1e309","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2931","original_object":"UniProtKB:P21453"}
{"id":"389f96ba-3b20-4255-9083-c0f5075e1f75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:819","predicate":"biolink:affects","object":"NCBIGene:12765","sources":[{"id":"urn:uuid:0d62ba06-77ae-4be7-94bc-6b1a5a73267f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:819","original_object":"UniProtKB:P35343"}
{"id":"8727d2f3-3afe-40a9-bef8-1d3d1579fc88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50861","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:d2833602-3859-491a-a5fd-84f870b394b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5820","original_object":"UniProtKB:P35408"}
{"id":"2877def2-01a2-4d33-9e10-6a2679d159d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229920","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:6aecd7f1-c2da-46d3-8e46-9a57d4bf016c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2672","original_object":"UniProtKB:Q07869"}
{"id":"921e9be1-5662-455e-bf0a-bebf7ca807d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:2b383c36-4473-4bd8-8d5e-854a276cde03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P08909"}
{"id":"29756360-1234-40cb-83e0-4f3415f1443d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11313837","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:5b9da751-a505-43bb-8d60-d1ffea6ecd20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1254","original_object":"UniProtKB:Q9H3N8"}
{"id":"d57f1b8d-434f-417a-9892-a8f75797ecab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817421","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:2d076d2f-176d-4067-8a4a-eac3bf3c360d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1540","original_object":"UniProtKB:P49146"}
{"id":"8b8de51f-9c83-46d0-adfc-52e915579266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:065a8998-9108-4027-85e6-2d7612d49d0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P35346"}
{"id":"05e51a7f-5cc6-429a-abf9-850daeda7960","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47575","predicate":"biolink:affects","object":"NCBIGene:598","sources":[{"id":"urn:uuid:228c41b7-a25a-4572-a141-633a75c9e7c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8320","original_object":"UniProtKB:Q07817"}
{"id":"0f9637d1-23c2-48ac-9eba-664e41ee90ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817416","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:81705b61-f38e-44c2-8056-97f7bfdf70d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1497","original_object":"UniProtKB:P48145"}
{"id":"5c284bbd-6ccd-43d1-b168-2d50485d78e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31684","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:0f6a2bfc-bbef-48e7-a3d2-41c192348e82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7399","original_object":"UniProtKB:Q14432"}
{"id":"e90e7d25-46db-49bf-8cf1-18162f5e8900","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16135","predicate":"biolink:affects","object":"NCBIGene:2865","sources":[{"id":"urn:uuid:fa03a0d3-e0fd-427c-8ea2-0ff4b2597646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1060","original_object":"UniProtKB:O14843"}
{"id":"667f76b4-2384-4c25-b3ee-f04ef89232f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95082","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:326e5fa7-8121-4f67-9296-a63a9eaf6a8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7033","original_object":"UniProtKB:O60885"}
{"id":"4a7b11dc-c03e-44d2-a417-2ddcbe5e167a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7D0YB67S97","predicate":"biolink:affects","object":"NCBIGene:942","sources":[{"id":"urn:uuid:a051a423-a708-45e7-955e-bc246a79216c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6891","original_object":"UniProtKB:P42081"}
{"id":"006ad165-3c4a-40dd-b05d-04e591c8298f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72551298","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:ab3f7b65-9c21-4066-bc8d-d82637b3e40f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6394","original_object":"UniProtKB:P41594"}
{"id":"d4c120ab-39e7-4279-8dde-871f197628e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195521","predicate":"biolink:affects","object":"NCBIGene:12747","sources":[{"id":"urn:uuid:f98daf97-fc8e-4327-97d1-74684ed0eb49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8167","original_object":"UniProtKB:P22518"}
{"id":"709dac6f-06ec-4880-a536-48c14d92441b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311229","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:58fd7a02-ad60-4a43-94f2-53e877c690e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1931","original_object":"UniProtKB:P43115"}
{"id":"5b469a2e-c73a-4f54-be77-112253e7df5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71460944","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:0740a873-e238-415b-a9ec-fe32d00dba98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11694","original_object":"UniProtKB:P35372"}
{"id":"772c61d3-1eca-4c64-b430-8c1626139dfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12492","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:9dad605f-23b5-4367-a0aa-ca713d808313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12492","original_object":"UniProtKB:P55085"}
{"id":"79ea0d5a-9bd8-4bb2-b685-45acbf3b7af8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180905","predicate":"biolink:affects","object":"NCBIGene:25469","sources":[{"id":"urn:uuid:3d36a258-993e-4d72-bb44-38c3474bc1df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2559","original_object":"UniProtKB:P15385"}
{"id":"9e1c4f66-a15c-4447-8fab-43a123cb9389","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139390026","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:f957db8e-a46d-4abc-8a91-2defc0b318df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12078","original_object":"UniProtKB:Q00534"}
{"id":"203e2ee3-3af4-4f84-ac74-bda4664088c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25081457","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:f724176e-294f-454b-8352-c1808cb66636","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1694","original_object":"UniProtKB:P41146"}
{"id":"020d6240-25d1-42d2-bb35-aeac0b0746e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V10P524501","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:8971ba33-1449-41d0-8f63-1951b5106644","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7497","original_object":"UniProtKB:Q9UBN7"}
{"id":"f9e518d7-f687-488b-b8d4-1099b820503b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134721","predicate":"biolink:affects","object":"NCBIGene:5406","sources":[{"id":"urn:uuid:024c942e-65e5-4d01-8a49-d75130d518c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11433","original_object":"UniProtKB:P16233"}
{"id":"ec9e3bcc-18f0-4419-8f8d-b318d4e4aa71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:6b9533af-f52a-416e-a00c-eba6e8d65be4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P18089"}
{"id":"63378a8b-615f-44e1-97e7-9ad9c5f9c5b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31932","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:aa9280e6-92b2-443f-98d5-ac0ecaaa9cfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:591","original_object":"UniProtKB:P30556"}
{"id":"aa573987-cb71-4903-8e24-2089846518e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926513","predicate":"biolink:affects","object":"NCBIGene:9149","sources":[{"id":"urn:uuid:817c103a-4cac-4bc0-9993-243b5d64588f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8161","original_object":"UniProtKB:Q9Y463"}
{"id":"4e5ccb25-80b4-4ffc-a182-4a54b6a87a36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755145","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:220cae0e-6827-4ad8-ada2-87681a54d4a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5712","original_object":"UniProtKB:P10721"}
{"id":"383de8a7-48db-42db-8752-afe243599eed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755085","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:9078fb32-dfdc-48d5-a0ad-2755f3397c56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4201","original_object":"UniProtKB:P48167"}
{"id":"75d9d0e4-56d1-4d02-97d0-4da6f00ce73c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124965","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:6a451e66-c488-44df-ad47-8b14ae40f716","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6624","original_object":"UniProtKB:Q9NRA0"}
{"id":"c93cdfae-2657-4193-be9e-fc4b24caa4b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:2b48ea5a-7bb3-4d7a-bfcb-3576bbd2051b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P30874"}
{"id":"ba147010-ff83-497d-9bb6-f4ec5fafc2d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:169876","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:88027fe7-1fb0-47d5-844d-4d89fd5c46e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10204","original_object":"UniProtKB:P03372"}
{"id":"c0c716f4-6baf-4507-848d-31a298ca3d9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57656761","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:5adb37f6-6a11-4995-8be4-6f02c361ed4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7825","original_object":"UniProtKB:P41597"}
{"id":"c72087e6-ce25-4cff-ab2f-b5786a4cc36c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155595153","predicate":"biolink:affects","object":"NCBIGene:7357","sources":[{"id":"urn:uuid:9a9612e6-35e2-4c25-af9c-9e61024dcbd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11935","original_object":"UniProtKB:Q16739"}
{"id":"1b894b85-3563-4515-b86d-1ce57db8c132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9891167","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:d949c6b7-3581-4a23-8dc0-20bd2a4d819a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:491","original_object":"UniProtKB:P43140"}
{"id":"984a9de5-83de-445b-9464-bf1bb890b86a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12989","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:62943ff3-e5e3-4b67-8713-576f09e681cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12989","original_object":"UniProtKB:Q15116"}
{"id":"2e4ab70c-7cc9-45ce-928a-025b0501a63e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:30PO842071","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:cc9ab164-5a07-4443-a19b-349c02617c8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3092","original_object":"UniProtKB:Q02769"}
{"id":"46f3c93c-a989-488c-9442-b42f028a4451","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:ae936f47-99a3-4113-aae2-74533eec713e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:P35968"}
{"id":"d904ac02-2de1-4bd7-ab56-bcc95842d928","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:96dd22d3-3f79-4d84-999f-d3c3c3cb49f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P31388"}
{"id":"ffb91916-7f8a-4f4c-bc0f-9b5956f1f26e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79997","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:6f00f982-214c-43c3-a6c3-0a0a1ec7955a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2743","original_object":"UniProtKB:Q96RI1"}
{"id":"245abc85-83f5-4053-a17d-8a10222c8ddb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2825","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:cb6eb229-fa82-4099-bcb9-85268cf89cfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12438","original_object":"UniProtKB:P59537"}
{"id":"586175d3-371d-4685-9961-392a6415889d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:7f384975-8630-41be-9cb2-8d7d1478d984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P35408"}
{"id":"b61be277-a3fa-4ffe-95c4-0f56b360304b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:850","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:b5c99614-9868-4226-aadd-8422f9baef16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:850","original_object":"UniProtKB:P61073"}
{"id":"792ed4ca-8e32-4a3f-908d-c5ab858f1ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:188397","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:b1442b62-becb-43a5-9037-cdf884d0e4e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2245","original_object":"UniProtKB:P30559"}
{"id":"79589105-fffd-4e57-a9fb-4c333341421a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91384","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:1ea6fe9e-516d-4ad6-8d8b-0b6e5908d7d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5980","original_object":"UniProtKB:P49841"}
{"id":"b37acd48-b3f4-48d7-a978-ce72c62833e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:081d00c5-9b7f-4373-bfbd-70cf52308887","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P35368"}
{"id":"e9db6fcc-f642-4180-940a-d7c902b9e693","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:39OM5Y4K2F","predicate":"biolink:affects","object":"NCBIGene:9194","sources":[{"id":"urn:uuid:3abb2fd4-1d10-450f-9a57-a2dc9ae31a35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10605","original_object":"UniProtKB:O60669"}
{"id":"77aeef7b-2bd6-44a1-9f6f-01a53f48fcca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:81326","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:d3487957-98b5-44f3-93d0-2c2359737c37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6500","original_object":"UniProtKB:O15552"}
{"id":"e1c62ca8-fa20-4b1b-a7da-37be4b481edc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73286","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:1bdc196f-69f3-4764-bfcf-f9692cdd0144","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:422","original_object":"UniProtKB:P29275"}
{"id":"974c5af4-e10f-4adf-ab83-2b8cbc440cf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18332","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:e1f5d586-e59b-49f1-80d0-5de2e6aaeb4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2635","original_object":"UniProtKB:P10828"}
{"id":"e7b0f722-0232-4a1d-8d89-53fd1988cd3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QR88H79VX","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:87b554f8-fd2e-4464-a839-71cfad122195","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9600","original_object":"UniProtKB:P52333"}
{"id":"4be9ea83-483b-48fe-808a-de499ca54bc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:eee5637a-348a-4cc2-9b82-7f287394b22b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P35968"}
{"id":"f47a2b91-12fc-4f14-8e15-7ed5f97c5a63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:c6904776-9a0e-46f3-9ccf-db642c08f758","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:P35560"}
{"id":"3f61cd91-5bca-49f7-8bfc-fb70b9180823","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KL7B6D38VC","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:7a27896a-4530-4337-977d-e834bcafb192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12319","original_object":"UniProtKB:Q13315"}
{"id":"a98ca708-4334-4668-afb9-921b3bdb2846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S98NFM1378","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:7026ec21-8e73-4cd6-aeed-c0f44963f9ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7698","original_object":"UniProtKB:Q9P1W9"}
{"id":"c0eed0c0-e8bc-4ac2-9b25-8b3907fda25c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1799","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:d70d6e17-1406-4f7f-b9ad-7c804875f8f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1799","original_object":"UniProtKB:P49190"}
{"id":"7a0fd7a7-d4e3-4bd4-98e0-fea339408592","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9114","predicate":"biolink:affects","object":"NCBIGene:2692","sources":[{"id":"urn:uuid:14f649c3-e345-4199-a902-d54fd79940b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9114","original_object":"UniProtKB:Q02643"}
{"id":"f014c6b5-2f0a-4e4c-9dd8-240ad30272f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1320","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:4c6f9ce4-2afb-4d6a-aeb9-3068cf824f50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1320","original_object":"UniProtKB:P33032"}
{"id":"9cc50ecf-b6c3-432a-98ad-d16ede66b951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:96711H97SD","predicate":"biolink:affects","object":"NCBIGene:217369","sources":[{"id":"urn:uuid:1a6aa135-78b9-48e7-bc54-8de00ccb5882","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2165","original_object":"UniProtKB:Q8VIH9"}
{"id":"ae4f383d-57db-40fa-9bb5-16c02adec6c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:53836","sources":[{"id":"urn:uuid:5532d600-d007-460b-9e0d-691579234d79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q9BY21"}
{"id":"ab9a2ac9-8461-40b9-918e-8634bd1b8a68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93363","predicate":"biolink:affects","object":"NCBIGene:209513","sources":[{"id":"urn:uuid:45407b38-2e56-4daa-a875-3c9fd9a77cb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5509","original_object":"UniProtKB:Q5QD15"}
{"id":"7349bf4c-c034-4de6-a19a-a9627880ba6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587343","predicate":"biolink:affects","object":"NCBIGene:56339","sources":[{"id":"urn:uuid:e5498224-0508-47fb-9850-c959df0a16d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13111","original_object":"UniProtKB:Q86U44"}
{"id":"2aaaf6ff-06c7-4f5f-8190-bd0a6d1861cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10426487","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:bff12b91-b8eb-4230-92f5-a9db34858a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:291","original_object":"UniProtKB:P08173"}
{"id":"1f048b76-c241-4a02-9116-59ae36405cd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:2ad41bab-08c9-4730-84b5-3a694a398822","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P28222"}
{"id":"dc6cc79c-1863-49d4-9ce8-e75a3c17e02d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JQ11LH711M","predicate":"biolink:affects","object":"NCBIGene:2167","sources":[{"id":"urn:uuid:55ab4ca7-7471-4c00-9377-a9f5dd47b45d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11124","original_object":"UniProtKB:P15090"}
{"id":"26fc12b7-531d-48e1-8aeb-84eb94f868e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3728","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:39b65f7d-5995-407a-92ac-465c48f43d06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3728","original_object":"UniProtKB:P21730"}
{"id":"fc9637df-b03a-4211-81ce-d86da625027c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813889","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:60790a81-99fd-4fe0-9a1c-9ef044d5b02b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5391","original_object":"UniProtKB:O08726"}
{"id":"ade63375-8d22-4dbd-8e5f-b8c2cd26ca45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167667","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:8433830b-22ae-4505-b946-b4b05ea98ec8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:481","original_object":"UniProtKB:P25100"}
{"id":"680d111d-6f6b-4148-8551-e6e9bbefe476","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124226","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:a25b0383-0792-4e6b-a4e7-85c2bd39e0dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:322","original_object":"UniProtKB:P08912"}
{"id":"74f340d0-67cf-4151-8a56-caae3b7a93b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:928QIN0R16","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:45358f58-61e7-4c2d-bc85-dfbf944f19b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:800","original_object":"UniProtKB:P51681"}
{"id":"08209c56-d532-47cb-9354-3dfff9691a42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841259","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:4ff07028-889a-49cb-a9c2-ef73b6147bcb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9005","original_object":"UniProtKB:P41145"}
{"id":"6c6f7ea2-2919-42d8-a26e-aaa0f0efc9fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53766","predicate":"biolink:affects","object":"NCBIGene:309004","sources":[{"id":"urn:uuid:df5d1484-3837-41c5-995f-19d6b7f15a17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9015","original_object":"UniProtKB:Q6TEK4"}
{"id":"202ef665-2572-4ca7-8c07-87a8bc60b6c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24889797","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:2c759dd3-e0a8-4bb2-8b62-aaa918627acc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10500","original_object":"UniProtKB:P41146"}
{"id":"b44e3f05-fc5e-4651-b778-d01d2f448f5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587569","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:853a94df-974c-41e4-9f6a-1aedd37bb010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11706","original_object":"UniProtKB:P0DMS8"}
{"id":"32e3e196-7a1a-4256-9bb7-6e4e76725434","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1493","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:46e581b7-8867-4c35-9498-49d74e6dddde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1493","original_object":"UniProtKB:Q6W5P4"}
{"id":"75cff793-c0a1-4992-819b-621783df2928","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28774","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:15ef8905-3834-4a24-bab0-8e0f20ad88da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2636","original_object":"UniProtKB:P10828"}
{"id":"9c097533-1d62-4da6-86ef-2cfe10493db9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24954989","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:1ffc16a4-96f5-42ae-967f-38e7d9fe22d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7774","original_object":"UniProtKB:P49286"}
{"id":"0aeaa9dc-a402-40b4-850a-cdb00c2899b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10079900","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:60ff7387-b70d-4fb3-8aca-6d556d7a0120","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6250","original_object":"UniProtKB:P25090"}
{"id":"5c2a6ebe-7c3a-4f57-87e7-af56a6285db3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19323337","predicate":"biolink:affects","object":"NCBIGene:2149","sources":[{"id":"urn:uuid:430fc246-937d-44e7-a0b2-4c34f16aa1c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9255","original_object":"UniProtKB:P25116"}
{"id":"a9efe183-6d1e-4bae-bed9-583a48bdd715","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125467","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:a287f99e-4eec-4e59-9e65-79ec8ec0c5c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1265","original_object":"UniProtKB:P35367"}
{"id":"e5e864ae-580b-47ed-8a45-25aadee80b99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755077","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:294035fe-f7e5-47c4-bebe-a4d363605ae6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4102","original_object":"UniProtKB:P39086"}
{"id":"287e5b5f-ec23-4c45-8d41-687e2a3b639f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AW987R473Z","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:7ae2e6ab-8dd5-43fa-940e-a0a731147c04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2071","original_object":"UniProtKB:P32745"}
{"id":"fbea2f6f-4503-45b3-9f44-ec565916eae5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53490","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:8bc63afc-079f-4f8c-9a8f-1e6506540ab9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1022","original_object":"UniProtKB:P25090"}
{"id":"232385b3-6ee3-416e-b6f8-f0b858bbeeeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13947","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:9b0da929-8de4-4fa5-a0b9-fc4abeac6ef2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13947","original_object":"UniProtKB:Q9Y5X5"}
{"id":"9a86d5e5-c286-470a-b430-17e1af15901b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:65UT4V5Z34","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:00d279c2-0555-4881-96ff-ecb47ab7bc58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:348","original_object":"UniProtKB:P11229"}
{"id":"fe7f999e-2b0e-4a73-95de-6e31e89f51ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:b635d620-deec-4d47-91c3-7e6c126fc937","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:86","original_object":"UniProtKB:O95259"}
{"id":"2b61aa43-4efa-4f05-b4d2-c58a3f99d306","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8459","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:02000bfa-1b2a-4eb2-aa78-7fd4e4b2ba55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7281","original_object":"UniProtKB:P14416"}
{"id":"446f7b29-fe59-4078-b408-2a5b5c886fba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:88334","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:16e364bd-fd4c-4d58-a7d8-22e3d270ca31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3431","original_object":"UniProtKB:P13631"}
{"id":"ea96294e-c636-46ab-914a-3b7cd1e43014","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92180","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:d1149c85-4ff8-4f34-9892-95d945a6ba73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5620","original_object":"UniProtKB:P25099"}
{"id":"e3c9a7f4-9846-452d-9bfd-1d8761eabae8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8R6ETA52F","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:699a1be8-2599-4978-8a7f-80142d580db4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12612","original_object":"UniProtKB:P04626"}
{"id":"20ec32dc-1770-4921-8c11-0a2cd4c47276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81391","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:c2b2e45c-4774-4c73-84fb-bcfd32ab7192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1267","original_object":"UniProtKB:Q91ZY2"}
{"id":"27a82753-136f-466a-8283-1329fb56f485","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165412766","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:c686d001-5705-45cb-8633-6a604e50d4aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12523","original_object":"UniProtKB:Q9H1C0"}
{"id":"388d9517-d284-4e09-9f3f-2af17e653545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7640","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:4db52ab9-a96c-4e72-a029-409b6f8da197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2404","original_object":"UniProtKB:P35348"}
{"id":"7dc32cfb-6b60-4666-a66b-4cbca47398f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11373218","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:7f66d604-7acd-4bee-9abe-45187c6fe424","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6471","original_object":"UniProtKB:P31424"}
{"id":"e6007052-6193-4b37-ab08-673d6c747ab4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:9132","sources":[{"id":"urn:uuid:cb270d98-523a-4fd7-a783-9dd74208c51e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P56696"}
{"id":"dfdff01f-41d5-4c24-9f03-0bb38a35f820","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H4X2M2NN5N","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:53798f63-1965-4953-9ece-7026f2013b9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9921","original_object":"UniProtKB:P35968"}
{"id":"0da17749-df66-4453-932b-3102bfff7da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755022","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:aced6d9d-0bc5-42db-a51b-26f27dd57967","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1965","original_object":"UniProtKB:P43119"}
{"id":"3b25baa4-e4de-4008-8926-59cb7913b22d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9791","predicate":"biolink:affects","object":"NCBIGene:84050","sources":[{"id":"urn:uuid:1467d6e7-eb2e-4867-8e0c-3190e19f284e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9791","original_object":"UniProtKB:Q64610"}
{"id":"0d575d08-a4f9-4db4-82d9-6087ca478bf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118796358","predicate":"biolink:affects","object":"NCBIGene:65980","sources":[{"id":"urn:uuid:530feb45-237b-425c-bb0c-4d7241445ff1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9146","original_object":"UniProtKB:Q9H8M2"}
{"id":"eda691ca-1b96-4ecb-bd9d-c4138ea59514","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90545","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:5a36ab1d-7232-4e2c-82ea-d06126a4e5ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7965","original_object":"UniProtKB:P48736"}
{"id":"b7eb21ca-d2a9-4ebb-9206-0e69c588b233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44584947","predicate":"biolink:affects","object":"NCBIGene:5125","sources":[{"id":"urn:uuid:c18c3e38-a4d8-44fa-961f-193af9af018e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8668","original_object":"UniProtKB:Q92824"}
{"id":"3fdbbd64-a532-4b75-9b7e-2b96a5d50d2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5862","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:0e7d8dfe-be15-46bc-ad52-57a484c4bc3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12575","original_object":"UniProtKB:P18825"}
{"id":"13d55f15-a133-43ac-8146-4a8d9f4cd44f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:28Q8AG0PYL","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:5d8c01f0-99af-4d29-81f4-70d1406334ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12737","original_object":"UniProtKB:Q03181"}
{"id":"ac57ccf5-03b2-48bd-b68f-073576d354f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40953","predicate":"biolink:affects","object":"NCBIGene:5600","sources":[{"id":"urn:uuid:1f43d8b4-72ee-4ca8-a8c7-d0018d931d2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5668","original_object":"UniProtKB:Q15759"}
{"id":"1d4de8ef-f8d4-4912-bbca-ed3daaf493f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46229","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:dfe20775-e7bb-4fbe-9e91-7e12c388e2ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1783","original_object":"UniProtKB:Q13304"}
{"id":"ac90d64a-749f-4c00-a0ac-7220be49842a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:939U7C91AI","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:ba9eb002-e58e-4a0b-85b6-9ede4e22c1f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10342","original_object":"UniProtKB:Q01959"}
{"id":"68cac855-d260-4e5a-9d43-09c1bed0f106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44351001","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:37e0656e-1b56-4359-8cb8-1236acbdec73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1507","original_object":"UniProtKB:Q63447"}
{"id":"898269b3-947e-4717-9f45-ba4ca28a2238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13870","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:75939a7a-3831-4ff7-b35c-083425887be4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13870","original_object":"UniProtKB:P43220"}
{"id":"04cc2ca2-b389-49e1-a57a-0fa9c1f345cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:cf837db0-4a8a-4a4c-be73-aebbea33abd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:P15390"}
{"id":"a100e940-2763-4a21-a598-0d3e6bce9bc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4998","predicate":"biolink:affects","object":"NCBIGene:3570","sources":[{"id":"urn:uuid:afddc366-ae26-4bb4-a5a3-bfb21dadf1d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4998","original_object":"UniProtKB:P08887"}
{"id":"fc8bcd71-7239-43c2-80fd-87f381fcc1b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993664","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:f5229a70-f7f0-4296-9bbd-e8855c1b8335","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12606","original_object":"UniProtKB:O43614"}
{"id":"4f0824bf-6937-493d-922c-c93cdba806c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64149","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:10055f79-6d89-4ade-a067-bedf78866008","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:106","original_object":"UniProtKB:P28222"}
{"id":"cd1c832f-df91-4a60-a9d8-4669661c83bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:fde516a4-4b22-4365-b14d-94b8f9d27410","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:P15389"}
{"id":"aa31dd57-81b6-4073-9824-065f483bffed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:af0a939e-07e1-4319-ad89-7365a38ce3b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2486","original_object":"UniProtKB:P63142"}
{"id":"9c6f1cd6-7b41-4023-8b66-3fb2fa2f5846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603904","predicate":"biolink:affects","object":"UniProtKB:P15823","sources":[{"id":"urn:uuid:028eb8b0-bed1-4bd8-b2b4-71b024e9577c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:506","original_object":"UniProtKB:P15823"}
{"id":"8c099c4e-9821-458c-8c59-3272ee0bdaec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:9aff191d-a67c-45ee-9ea3-1beb131ceb40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P28223"}
{"id":"8847736f-0ce9-44f8-a3be-b93b3b8aa2d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9850711","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:0a18a772-730d-4732-9ab6-b53bfc5e2abd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:903","original_object":"UniProtKB:P56481"}
{"id":"4e935bff-7ca5-447e-aded-bd4d245c4683","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925685","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:c77d0f84-a19a-4d25-9eae-2e5bbaa7a6a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10597","original_object":"UniProtKB:P36888"}
{"id":"601b9707-37c1-48b4-8ee4-c3ee47ed4dec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:9f2bd83a-76ee-4b72-aa84-e50dc76d7e32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:Q9NY46"}
{"id":"d8f2345c-66d6-4300-9bf9-7fdbc77468b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155296110","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:849cc3c4-c727-443f-9044-78ccad9e0e07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12381","original_object":"UniProtKB:P07949"}
{"id":"55d62597-4e51-426e-9af3-ba374006f70d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8CZO0970G3","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:769f0878-8016-4b87-88b5-2ea07163b7e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4241","original_object":"UniProtKB:P31644"}
{"id":"fc62f577-9457-4629-89f8-fd99a001df95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841259","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:9bbe434e-9f35-4627-8742-0f88872237b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9005","original_object":"UniProtKB:P35372"}
{"id":"c09d7458-07af-4584-bbda-3a2df5893764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:fb1d9217-c63f-40ec-ac40-383567df4610","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3976","original_object":"UniProtKB:P32297"}
{"id":"6facf98e-1c30-4df0-9395-215cbbd29423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310983","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:8f9cd60b-cb3c-4d1b-99e4-86c6760bf36c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1711","original_object":"UniProtKB:Q9BPV8"}
{"id":"47e43f9f-f62b-4092-bc6f-a7964240b24d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44392752","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:94d96ead-c916-426c-932f-ba46f80d97fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2908","original_object":"UniProtKB:P61793"}
{"id":"f08befdd-5a7b-44f8-bcc0-aee62a56a4a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:56226226-14c3-40b1-a14a-6875724c0a07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:Q62805"}
{"id":"ade436dc-1ffa-4b3c-8b06-57a60eec11e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2448","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:6504ff82-6bca-4812-9be5-69e359c2e8c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2448","original_object":"UniProtKB:Q8BLA8"}
{"id":"29fe3871-674a-48b1-a664-0d748d018a2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4324257","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:082522d2-b4f0-4f49-813f-715eaef4820a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4080","original_object":"UniProtKB:Q13224"}
{"id":"6ead7246-1f78-48ce-a5a0-e0f5fade9c1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8221","predicate":"biolink:affects","object":"NCBIGene:3620","sources":[{"id":"urn:uuid:8f8b3e68-e061-4f2b-aa68-b0dcee3106ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8221","original_object":"UniProtKB:P14902"}
{"id":"145750d7-8d27-4c97-ba64-bb1d5ec4ed96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:893637","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:ec36b8f7-8212-4409-bd22-c0a2e7b2010c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7870","original_object":"UniProtKB:P39900"}
{"id":"7d8ed2f3-6d44-4cc4-b9fa-c08978bb3c1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63599","predicate":"biolink:affects","object":"NCBIGene:6240","sources":[{"id":"urn:uuid:9c19de0e-c038-402a-860b-14f03d07dffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4802","original_object":"UniProtKB:P23921"}
{"id":"6e456f98-0d13-4af9-ac8d-f5e4351ee13e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:127f9b01-d559-4e63-a06f-52a4a61cdc5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P28222"}
{"id":"fe45699f-8e77-418c-bc61-dff5515c997d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11922","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:31ce8795-c0de-46f9-ab30-0cd6f37dd7a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11922","original_object":"UniProtKB:Q8WXD0"}
{"id":"d79a58aa-dd39-4cb8-acc3-47f11754c55d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M6RN4LQ25S","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:a7fc19b1-2501-4ea6-8bef-0e0324c1a054","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11178","original_object":"UniProtKB:O60674"}
{"id":"79a0d4fa-1d1f-40cb-8f71-5ae14311c271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66550979","predicate":"biolink:affects","object":"NCBIGene:1075","sources":[{"id":"urn:uuid:99336db1-0b73-459e-8f0e-819d78561629","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11179","original_object":"UniProtKB:P53634"}
{"id":"c426e6ff-34e3-4555-acb4-683ec3482bd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:e3fa64d6-72e3-4b88-94da-331eb9e83596","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:O15303"}
{"id":"4fa3ecbd-7ee2-40da-9930-247f53315219","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553165","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:8bed1a08-3110-4582-9994-91ae1bb70565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10273","original_object":"UniProtKB:P34972"}
{"id":"2632e7ee-2aa6-4102-a15f-6c981d352fc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4206","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:78d14021-0422-4fc8-b908-0afdc61b28a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4206","original_object":"UniProtKB:Q92508"}
{"id":"a2f06892-54e7-418b-8e48-41cbca476162","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91448","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:37c6930c-9e8e-4276-a374-45b61260f800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5940","original_object":"UniProtKB:P48730"}
{"id":"43ebac04-e468-4188-a92c-230ea9c13e17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:546a7a32-c2ef-4b84-8508-ffaab97c0035","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q5XXA6"}
{"id":"afe14840-ccb6-40d7-8b01-14c03426a780","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:252716","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:fc21e02f-4b44-48bd-af0a-d8695e4ac3d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:466","original_object":"UniProtKB:P0DMS8"}
{"id":"7dfe9cf5-6735-40b4-97cc-3b914d8d2ed7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593559","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:108766e0-8fe6-490c-94a2-344ac8fdd8a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10518","original_object":"UniProtKB:P41145"}
{"id":"f4ff5c9e-29ab-45d7-83db-9299a971638b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947023","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:4e4ea754-30a7-4a10-a458-27a7726004c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3007","original_object":"UniProtKB:P04035"}
{"id":"4279d631-7f83-4ed4-aa11-741ad44769a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2089","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:afb2d724-d383-4237-b6e1-3ea6d14d48bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:107","original_object":"UniProtKB:P30994"}
{"id":"db572c99-e1ac-4804-a973-13cb2764b199","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733035","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:1a3db712-47e1-4c98-9c46-3188460b724e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11314","original_object":"UniProtKB:Q9HBW0"}
{"id":"c5eaee0f-a0cb-4732-a369-fcb7ce8b317c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:961606","predicate":"biolink:affects","object":"NCBIGene:3164","sources":[{"id":"urn:uuid:013d0a85-4b9a-4e3b-9ad7-c4a3a44dad4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12997","original_object":"UniProtKB:P22736"}
{"id":"71dff6ba-a7de-4a59-b429-8a565ca74bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6219","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:b1b6fd78-ac1c-4db8-86c0-15eaeffd2a5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6219","original_object":"UniProtKB:P31422"}
{"id":"be210f3b-f21c-4fc0-a237-05a27aef644d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817488","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:20ba1a8c-b0c4-4080-aef8-cbd0c3325ab3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6165","original_object":"UniProtKB:P30550"}
{"id":"850bd84c-9582-42b4-a76f-adeef21ed6f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13836","predicate":"biolink:affects","object":"NCBIGene:7113","sources":[{"id":"urn:uuid:2d64e167-b860-4e9a-bf29-d6c4b6cf989e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13836","original_object":"UniProtKB:O15393"}
{"id":"c48cc5f1-9422-4bf8-bac3-8b5b417ba416","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6666","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:8b9a8004-8ec5-4f4e-8e63-263658cf40c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6666","original_object":"UniProtKB:P32238"}
{"id":"6e51baf4-b62a-4fbf-a301-b9fbdf6796c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:0c09c3da-f3ab-4c06-bde4-96adfc9ef93c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:O08858"}
{"id":"3aab3c35-aa20-424d-85b1-5e6c1243002d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93752","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:d8583dfa-acbc-42c2-a367-1dfde9680202","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7955","original_object":"UniProtKB:P42338"}
{"id":"99e5cf2e-a1da-4dbc-af55-a964886fc1c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8774","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:c0cd10cc-d863-4530-a9f3-e8e5517d43cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6339","original_object":"UniProtKB:P12821"}
{"id":"b79fd50a-ba1f-4923-a036-421a4bf0229f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:4dab2173-e0fd-4ff9-af30-7a24bdc9f49b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P41595"}
{"id":"f01b67fd-a62a-4266-9e53-adb9c32def87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11125","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:1457ed75-1605-43cf-8762-77e82b72068e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11125","original_object":"UniProtKB:P07766"}
{"id":"1e666f88-80bf-4c76-b8a4-4528871f2b87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2218","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:83cde142-c2cb-4d57-8120-63bfeebcf864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2218","original_object":"UniProtKB:P30559"}
{"id":"a532176d-39c1-414d-979c-fc3251daafda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755217","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:e17bbf04-f6b0-4af4-925c-4374b0b34358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6393","original_object":"UniProtKB:P31424"}
{"id":"d408f4b2-7584-40c3-bef2-63e20ab67a18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91336","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:c6e92b9a-35c7-45e8-8033-dfc4868e3feb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5718","original_object":"UniProtKB:O14965"}
{"id":"05586d29-f105-4304-8aca-15c282048529","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GKF8S4C432","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:7a248dd4-f6dc-4869-a10f-a8e43302c214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9601","original_object":"UniProtKB:P35916"}
{"id":"9d8563a6-ecd2-4ab3-a73a-3a0133fad5de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98Y1I8ZD4M","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:e9e39adb-47b0-42fc-8e8a-095e7beffa48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4082","original_object":"UniProtKB:Q05586"}
{"id":"2bb307ee-8a78-4dc9-92f1-94acf851ce6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3441","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:8d8bdc5a-a69d-4ef8-adcd-b74d31b14bf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:551","original_object":"UniProtKB:P07550"}
{"id":"b174c1ff-32c7-45bf-a124-5933781e8cd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91726","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:818f2291-9985-4fcc-a4bc-8c7a6cb64293","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2705","original_object":"UniProtKB:P37231"}
{"id":"39f27782-48cf-4b32-8c89-9c28c9ac63d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12467","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:9da00c70-3e00-42ff-9dee-07aaef5b76d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12467","original_object":"UniProtKB:P59537"}
{"id":"81d87e1d-b789-4838-ae21-625c2f0f2997","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:703746e7-d2b5-47fd-95af-1807b86d513d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P21918"}
{"id":"c6b95fbb-21e7-4108-b085-c570cc1ae23f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24794417","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:b6ecdacf-7ac9-4dc6-b407-7762cf748e7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4168","original_object":"UniProtKB:Q13224"}
{"id":"1efaeee1-c860-4f8f-b739-26a1d656549f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57928403","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:821cc658-0a6c-4317-9ee4-3c07511cf18e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8315","original_object":"UniProtKB:P52333"}
{"id":"7f9a0606-276d-4558-9563-e5aad6a391c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137017382","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:012098be-eb78-4789-a909-114b80565900","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12611","original_object":"UniProtKB:Q9H2K2"}
{"id":"bde24c2b-6a20-47a3-aeb5-b0308e88827f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91471","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:3f1fe0e6-bc7a-4526-ad02-6d27ca3f0ade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5672","original_object":"UniProtKB:P36888"}
{"id":"0df4b140-e94f-41fc-a3b9-7c50959e0358","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132992142","predicate":"biolink:affects","object":"NCBIGene:8711","sources":[{"id":"urn:uuid:ecd6d835-8a07-4430-965d-9c3243f9f55f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9929","original_object":"UniProtKB:Q13470"}
{"id":"d5bf5d1d-c5db-44d6-bfd4-acb005bd7195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2101","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:ebb05b5f-a79b-4dbb-aaa9-b52f9633c471","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2101","original_object":"UniProtKB:P25103"}
{"id":"c911abb8-d17c-4e49-ae7d-05e2cae71c67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122530045","predicate":"biolink:affects","object":"NCBIGene:23945","sources":[{"id":"urn:uuid:64a8ee16-0047-4696-809b-88100ea782a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11816","original_object":"UniProtKB:O35678"}
{"id":"8847a217-76d9-43ac-b19d-6e664694c858","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102336704","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:4da7673f-2df9-46f7-8373-c0cf9a635d10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9613","original_object":"UniProtKB:P21554"}
{"id":"017f6a31-a431-4be7-b6ae-265e00f627ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:168396","predicate":"biolink:affects","object":"NCBIGene:3614","sources":[{"id":"urn:uuid:d2716a8c-0ae2-47a3-b385-f5e2a4542d0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6832","original_object":"UniProtKB:P20839"}
{"id":"f519f077-836a-4101-8a5b-52910ca57c1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755221","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:17f0228a-06a2-48ae-ad8b-ae525cff3db3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6433","original_object":"UniProtKB:Q8TCW9"}
{"id":"ff0ba903-e4d3-4872-b094-d77154375b81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11659955","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:e449dfb6-0d66-4180-80f2-f85f4416a62a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:8521","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"8db7bb1b-2fe9-4424-be9d-2565c68e79c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4057","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:b6301122-586a-41ee-8cd4-0e16c5139534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4057","original_object":"UniProtKB:Q96LB1"}
{"id":"3b6f525b-7231-438b-b4e2-b7fdb63eeb99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10460101","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:cd8a9cac-51cb-4f99-8340-711144f5aba9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3070","original_object":"UniProtKB:P37268"}
{"id":"89a37dbc-c687-461f-8157-390de9f72b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182389","predicate":"biolink:affects","object":"NCBIGene:91","sources":[{"id":"urn:uuid:0490d937-7a56-48db-bdeb-4b48b875076a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8120","original_object":"UniProtKB:P36896"}
{"id":"cd2d0545-21f4-4d89-b378-f41044cd6fd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2521","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:d6f1bc44-af7f-475a-95b6-7f0469af5829","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2521","original_object":"UniProtKB:P54282"}
{"id":"992f7f95-1be5-4ff9-9dd4-7bcd8f2af7b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91359","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:1344e85e-16b6-4de7-9728-7efc63aaf73d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8059","original_object":"UniProtKB:P48736"}
{"id":"39479852-472f-4887-8f1b-2f0e5af2438d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28125","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:0a3536f2-ecb2-473e-92e8-d58600bd0855","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1051","original_object":"UniProtKB:O14842"}
{"id":"d3391835-b1f5-4450-af8a-06e106e8bd8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177580","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:164ff6d7-4297-4f1e-8416-0907bc59c96a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1623","original_object":"UniProtKB:P41143"}
{"id":"200156d8-c398-46c0-8834-e0c69ef43ccf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130169","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:4f680aa5-5cfc-4284-af26-c0bebc92bba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:331","original_object":"UniProtKB:P08173"}
{"id":"be8e23e3-c14e-4920-a1d0-3280bdfa8ee8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:ee16ea81-5e50-4175-8742-287d04ad324f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P28335"}
{"id":"a26de84e-9e91-41d5-9596-abf6599557ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:a283a87c-ac0f-448e-9ec8-5c87f906060e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P28221"}
{"id":"5de28664-f236-4fa5-abbd-6d0349ebf7d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3907","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:2a43156b-b965-4480-93d5-7cf013b86392","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3907","original_object":"UniProtKB:Q9NSD7"}
{"id":"dba86ff5-a653-4d17-9f02-a796cfca5c7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:1a07dbf4-f078-42ba-bd51-522b7e957c72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P31388"}
{"id":"fa8eeb1c-d8d1-4bc0-af67-7acded02ab67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2212","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:5a8943b0-33da-4d59-82ec-0a1c28642607","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2212","original_object":"UniProtKB:P37288"}
{"id":"05927790-d952-4546-9706-11ec32212190","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311186","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:5e0a841c-6a67-4e20-ab29-650bda2798b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1266","original_object":"UniProtKB:Q9H3N8"}
{"id":"c7525cb0-3d47-4b1d-b596-a733b474c2d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82698","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:397a29d1-76a7-4bac-808a-17b26ae55fca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2890","original_object":"UniProtKB:O43613"}
{"id":"239ac396-6b34-43ac-9be8-199578f447a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13429","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:ff660f7b-4983-492b-b538-7175de3da891","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13429","original_object":"UniProtKB:P29597"}
{"id":"894ef616-19b3-4f4b-b011-a4e130ad9dba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60201789","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:3397ce5e-323b-4d0d-a0df-f97990970344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8379","original_object":"UniProtKB:Q16581"}
{"id":"f5f2fe65-a746-4739-952b-c4077dfb0856","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2218","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:a599e15b-9b7e-49a2-831e-dccbc0a1f6ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2218","original_object":"UniProtKB:P37288"}
{"id":"e9a44e50-5d98-425b-9e20-546dfb5799dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11307323","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:a0caec1d-8536-432a-9c7c-bc83feb80160","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6665","original_object":"UniProtKB:P32239"}
{"id":"35b3af51-b43f-4758-9e7f-8b7d277cf631","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67119","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:7f7170c3-6b6b-416b-a673-1b7b01196d49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1782","original_object":"UniProtKB:Q6NS65"}
{"id":"5b093701-af7b-4874-be6c-75e7c8fe0617","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:51M3FB9B9E","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:ab0d561a-5656-4441-99d9-faa442b7fbc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9979","original_object":"UniProtKB:P41597"}
{"id":"b07512a2-edd7-4f36-b70a-a56ab8fbda8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699450","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:7d144a3c-692b-423e-8537-ea98cb1e2ab9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11147","original_object":"UniProtKB:Q9NYA1"}
{"id":"6f8e808a-d829-421a-9b8f-2a1bd43aae5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2060","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:e72889cb-6155-4c39-9f5d-929fe0fa08ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2060","original_object":"UniProtKB:P30875"}
{"id":"c3c21aa4-d75a-4ee6-a00c-5fa70353cecb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:75d73b57-daf9-4809-b818-79e6275fa291","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P35968"}
{"id":"832020d8-697d-4952-a7e3-54c18e4f8a04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6116","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:369d2a60-6ffb-43c9-924c-b84aed18fb7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6116","original_object":"UniProtKB:P47211"}
{"id":"b2351fbb-1945-4d8d-bb4e-b8e257cd9f73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TE20GB753F","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:5278ef03-de2b-4a95-b83b-6ae7e0b18199","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9930","original_object":"UniProtKB:P09619"}
{"id":"1881241c-b661-48a4-bffb-47172ddc3b33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:83e7dfde-226c-44e1-9cf6-c2dd27ed2e66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:Q9UKV0"}
{"id":"74bb576f-026f-4b09-bb3d-6fd92e0e34fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90488821","predicate":"biolink:affects","object":"NCBIGene:25051","sources":[{"id":"urn:uuid:bf9136aa-3088-46f1-8bce-13eebd2c3b0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6524","original_object":"UniProtKB:P32301"}
{"id":"f1cf5560-26fa-4e1d-9b9c-23d6033618a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5128451","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:630abb23-b853-4661-8663-3e7c0aec9f44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:646","original_object":"UniProtKB:Q61125"}
{"id":"13d25e7b-7816-40af-a5f2-d28e23c97078","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125467","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:002f00fb-b00a-4071-af9d-214115e89656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1265","original_object":"UniProtKB:P25021"}
{"id":"5facf1ab-8f23-4f01-994f-4542d03286fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9949081","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:22b0a2dc-3f20-4564-93cf-15a603e7958d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3136","original_object":"UniProtKB:Q02769"}
{"id":"31923aa8-fe2e-4563-823b-ff545324b02b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139334","predicate":"biolink:affects","object":"NCBIGene:1621","sources":[{"id":"urn:uuid:13257139-a054-4a69-bd28-8ba85c2d3433","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6630","original_object":"UniProtKB:P09172"}
{"id":"8abe6545-5675-425c-bb0e-51ac45180f1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699463","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:a46dd57d-c9e4-4576-8b2f-ffc718fe908a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11220","original_object":"UniProtKB:Q9UBN7"}
{"id":"bbcb7724-899a-47d9-8e68-660388be2c98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177580","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:c298161b-3435-4906-9780-825594ae8210","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1623","original_object":"UniProtKB:P35372"}
{"id":"e97318ad-ead7-48cb-9edd-312c0e4a7393","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035449","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:e2d1150b-a9ae-464b-a037-a28264214ba9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:638","original_object":"UniProtKB:P32299"}
{"id":"68fe3c59-bacf-4cba-ab9d-678019b1c822","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:757","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:e9d1ca40-000c-49c9-9323-03cac87ace36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:757","original_object":"UniProtKB:P32246"}
{"id":"0f5ebe68-addf-47e7-9f3e-1cfe4224ef02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10710647","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:ebe8d3e7-8f5f-4e51-98bf-ebf106b8a443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:395","original_object":"UniProtKB:P25099"}
{"id":"b7a01264-943e-4e01-af61-de12572eaea0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231208","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:897b9e08-678a-4759-959b-498c4fc915eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1934","original_object":"UniProtKB:P30557"}
{"id":"c5cdb6a2-5977-47c4-ad81-41b319d718a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27965","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:e86b0a3d-de70-4191-9673-c865c2ac6af8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8981","original_object":"UniProtKB:Q9Y5N1"}
{"id":"0766b145-3b5c-483b-ba8e-70243c4caec7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:9ec1edc0-273d-4106-912a-c341182726d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:Q08881"}
{"id":"d6b34a89-f001-4764-a3a1-5ab40d9b1dea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604893","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:879f66e3-8f64-4a3e-b5f5-dcc8eff3b4f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1424","original_object":"UniProtKB:P41594"}
{"id":"1c30bfca-1f59-4c23-82f5-f72b9c66c5d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494341","predicate":"biolink:affects","object":"NCBIGene:54814","sources":[{"id":"urn:uuid:c98fd125-510b-43fd-8a99-8aad4d972c7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13400","original_object":"UniProtKB:Q9NXS2"}
{"id":"624c93d0-331c-43d3-ba2a-3f6f94f94c7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9434","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:7cd0fb63-d36c-4222-9dfa-1d9bdc72245f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:592","original_object":"UniProtKB:P30556"}
{"id":"5f8ca47e-4d89-4c1b-8d16-a8355a1037b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4869149","predicate":"biolink:affects","object":"NCBIGene:676","sources":[{"id":"urn:uuid:e98ba56d-fab1-4e38-8aa5-6a80c27d367a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11690","original_object":"UniProtKB:Q58F21"}
{"id":"90634c69-b2c9-4664-aa94-feb4b1e3da97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600335","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:0a6db4ad-8a5e-4a54-b072-f4f57e97b1ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10549","original_object":"UniProtKB:P52333"}
{"id":"9318e69a-d4dd-4451-9125-f01ac6e3f042","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7949","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:f2164874-51dd-4a2a-9345-7b613bdafe1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7949","original_object":"UniProtKB:O60674"}
{"id":"b9338c5e-d87b-4008-90e6-dcf6e5017982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:56R994WX4L","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:ee1131f7-a506-4c0a-b517-2b5da06c28e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7839","original_object":"UniProtKB:P52333"}
{"id":"05d4919b-8bf9-403d-9efb-46c698c8ee0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:950O97NUPO","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:c8e1c710-efab-41b5-ba80-6c9e35dd7ef3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5614","original_object":"UniProtKB:P30542"}
{"id":"1a58ee35-1776-4fd6-81be-4ce1f052a2c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177472","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:f68ea28a-63bd-4f1f-a4cf-a427de09579d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1929","original_object":"UniProtKB:Q62928"}
{"id":"896c8d56-0729-43de-9508-5590da55d76f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104872","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:9b67911e-e796-40b5-b7f2-0d625fb6ad00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5260","original_object":"UniProtKB:Q08499"}
{"id":"b72a5867-2bb3-4450-bb0a-fae1f586ca56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68534","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:5904885b-33f1-4d3d-bb86-9c183571391c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6812","original_object":"UniProtKB:P10275"}
{"id":"4ed402b9-5adb-4f01-9840-256c17fffea8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27607","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:1a67249a-bddb-4605-a929-259e8229d931","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2499","original_object":"UniProtKB:Q8K424"}
{"id":"c3a77774-79ae-4335-b33c-0027cc68846d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559100","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:4bf05da8-8329-4a7a-9f4f-b74fbb036ffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:219","original_object":"UniProtKB:P31388"}
{"id":"785e48e6-c478-424a-9434-36c0f99fedd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6112","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:f73b5c18-84f4-4174-b52d-574a53fb7361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6112","original_object":"UniProtKB:O43603"}
{"id":"1b75df4e-efef-4924-aca4-a84a960598c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185944","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:d33acd81-2798-4764-b8c1-d57639a7bbb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6033","original_object":"UniProtKB:O14965"}
{"id":"dee15dcc-002b-4984-b88e-38ee3aca57f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:33c7348b-3dbc-4e90-9247-9aac857b6df6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"mixed_allosteric_modulation","original_subject":"GTOPDB:4366","original_object":"UniProtKB:P47869"}
{"id":"63d02828-0988-4111-8ec8-0a16523d1e29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827363","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:36ff69c9-1339-4ba4-b3d5-fe979ee78dae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8505","original_object":"UniProtKB:P32247"}
{"id":"85e276ee-0e29-4ce4-8c39-98361e4bd5ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156440741","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:0cd63126-50f5-4980-9fc1-fbd8f47fc8eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12375","original_object":"UniProtKB:P30530"}
{"id":"9de8982c-2696-4805-a114-6289be89d8eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1308","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:397b6dc1-1e4b-4238-b90a-641b41bfcad5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1308","original_object":"UniProtKB:Q99705"}
{"id":"6bb4f765-58aa-4ce1-b920-3df65e65a65d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679545","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:9b5e7fb6-35c1-4419-82c9-836e7730cd61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11907","original_object":"UniProtKB:Q8TDU9"}
{"id":"38fb3168-1e8a-43de-9ba5-afddfc8c4325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:6f95d2f3-b1f4-453d-b3e9-6cb04eab9b96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P31388"}
{"id":"ac9f93fc-1f73-42ac-a706-c24ae0ee5637","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:79885","sources":[{"id":"urn:uuid:78bdadc6-683c-44e8-86d6-b2a73111b1a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:Q96DB2"}
{"id":"e167258e-64b9-455e-9a69-dbdb94d85b60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:755","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:49bc2d46-5a81-4d12-b518-c56f154d6a17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:755","original_object":"UniProtKB:P32246"}
{"id":"c9482d1c-5f91-4763-8360-80422b8a46a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11763","predicate":"biolink:affects","object":"NCBIGene:1191","sources":[{"id":"urn:uuid:280aa740-e203-4d3a-b4a9-efceaaeb5e20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11763","original_object":"UniProtKB:P10909"}
{"id":"a454fad7-ef36-4beb-ba14-6b2b893bcc7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3559","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:5d77d62a-aa28-46a5-b3f8-e2d6ada4c94c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3559","original_object":"UniProtKB:P30551"}
{"id":"ffc26271-418a-42f6-a197-a663fcdaffbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2569","sources":[{"id":"urn:uuid:b1787668-08ce-403b-892b-e63715519aca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:P24046"}
{"id":"af154662-ebdc-4618-a064-8b17f0eeb672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145374","predicate":"biolink:affects","object":"NCBIGene:3418","sources":[{"id":"urn:uuid:856606ed-b21c-403b-bf99-8e17ee5e5f8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8960","original_object":"UniProtKB:P48735"}
{"id":"7050382a-655e-43ef-9bb6-f9d1ecb864cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133823","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:35c5a6b1-8c34-406e-a70c-286910339afe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3592","original_object":"UniProtKB:O60755"}
{"id":"5ba60607-d9b8-4d63-bbd1-6fa792ccfcb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:8593274d-b13f-404d-bb16-56f83ca337a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P41595"}
{"id":"8eaf2def-512c-4f23-bba8-38136b599cdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V2GJ2XVK6G","predicate":"biolink:affects","object":"NCBIGene:10769","sources":[{"id":"urn:uuid:4c25246f-90b1-4a3f-9b39-6f6f039d67e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13145","original_object":"UniProtKB:Q9NYY3"}
{"id":"46f0e90b-b6b7-4226-ac9c-1edf933b3254","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321159","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:859e9aaa-ffa0-43fe-acfb-f253754bb72d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10156","original_object":"UniProtKB:O60674"}
{"id":"4d9e51b0-1c9d-44c4-85ed-d1abe5789341","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5693","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:9e32f75a-20a9-41b9-b063-8953f5893251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11069","original_object":"UniProtKB:Q6IQ20"}
{"id":"2b3d07fc-587e-4776-a554-e2bdb9b2a2bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6147","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:ff72aa5f-ac06-46b2-b5a0-43761d02c641","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:622","original_object":"UniProtKB:P21729"}
{"id":"f5493fc5-44bc-4c57-b4a4-71fd0975c8f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76317442","predicate":"biolink:affects","object":"NCBIGene:65980","sources":[{"id":"urn:uuid:dea0c353-27d4-4ada-90d2-9c96c8cae3b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8824","original_object":"UniProtKB:Q9H8M2"}
{"id":"868a5075-ce86-4023-9e4d-0245c58bc48f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817474","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:9bd9f2c0-419d-47c0-9c21-ae2601a3111e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5357","original_object":"UniProtKB:P47211"}
{"id":"798f0aba-3ca7-466c-a942-046595ff7215","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135666","predicate":"biolink:affects","object":"NCBIGene:185","sources":[{"id":"urn:uuid:635499e8-c962-4de3-9c4e-98709d6c185b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6898","original_object":"UniProtKB:P30556"}
{"id":"d07ac406-ed5a-48df-823f-4480c210d754","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40021","predicate":"biolink:affects","object":"NCBIGene:7067","sources":[{"id":"urn:uuid:6fb7e470-52ac-434e-b88e-ca740c3c5c8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2637","original_object":"UniProtKB:P10827"}
{"id":"f770c6e7-fae6-4bb2-970a-fc2f9d50ee60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232408","predicate":"biolink:affects","object":"NCBIGene:7054","sources":[{"id":"urn:uuid:1b45c23c-9827-4448-b33f-53594a39ac9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5094","original_object":"UniProtKB:P07101"}
{"id":"6c00e3e4-3bd1-4f92-831a-7dbe40f8490f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118556943","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:3320024d-f4b6-4246-b9cc-e1b448d1b984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10365","original_object":"UniProtKB:P42338"}
{"id":"cfd7ed4a-92fa-452b-91d3-607d0c8fcd42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4784","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:ca3966da-8624-4e0f-85ad-6600996a98e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6322","original_object":"UniProtKB:P12821"}
{"id":"22bebc07-6376-412f-a01c-e8df5312f06f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92375","predicate":"biolink:affects","object":"NCBIGene:8560","sources":[{"id":"urn:uuid:995728d0-1401-4139-af30-6236205c32d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6041","original_object":"UniProtKB:O15121"}
{"id":"75fa215f-eebc-47c9-beff-e0f66440a0fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188612","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:d46d80d2-5c64-42cc-afad-3b61d1c0fc37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7916","original_object":"UniProtKB:Q9UBN7"}
{"id":"78ecb467-8869-49c5-ac7d-4e325042d1cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31399","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:8d06d585-bb3b-4c67-b626-e34aaabf3137","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7767","original_object":"UniProtKB:Q02294"}
{"id":"730e519d-a4d9-451c-820f-8e373a60114b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133599","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:8065384b-3baa-4b14-b34d-6fd44cbe081f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:846","original_object":"UniProtKB:P61073"}
{"id":"33b664f8-7815-4fe3-b0ab-f2520d21c66d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44331589","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:4a098171-71e0-4e69-a567-d6585d380881","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2978","original_object":"UniProtKB:P51639"}
{"id":"1093c0da-0860-4569-9da7-00d174a26fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GEZ43HM6NW","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:63ef1c3a-1547-4c0d-bb53-3b0703fc0b50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11659","original_object":"UniProtKB:Q04759"}
{"id":"dfae82fb-9878-412a-ba4e-05b6363d9c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156587563","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:f498ed29-f0b9-489a-8842-a42a5fd5f7b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11662","original_object":"UniProtKB:Q00534"}
{"id":"e2b77c95-edce-478e-865a-9b2019b99453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63977","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:ddb04559-b38c-43de-aa9f-230d00e63594","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6159","original_object":"UniProtKB:Q9NPC1"}
{"id":"ffc1ca40-11e2-4e10-b704-3f0a700106f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CKP8AS5W73","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:04682693-0abf-4a58-8715-f84508a1d987","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11972","original_object":"UniProtKB:Q86WV6"}
{"id":"5fd3114d-eed1-4cbd-9742-6f95c50582e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:34915c9d-e71b-4136-a48a-d296c943e55b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:O88626"}
{"id":"c16304af-bf2c-4dda-ae69-6e87f121dda1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:48ce260f-3942-4adf-8f56-0621b7ae580f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P47898"}
{"id":"01f53495-ae91-4816-b056-048654ab2015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10818542","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:9c4c9cb2-cef2-48e7-9757-082c47f5aafd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3098","original_object":"UniProtKB:Q02769"}
{"id":"5ac84d58-fffc-4a77-a886-21b09c52012d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL413188","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:a3c0b015-30b2-4c06-8425-f982b4c68342","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5991","original_object":"UniProtKB:P49841"}
{"id":"8c52f483-a463-40cd-92ba-51aeecf94400","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13385","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:dda8bea5-0315-43b6-9d81-6993f77e3312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13385","original_object":"UniProtKB:P24941"}
{"id":"fb581acb-c9ba-485e-aed5-559ba3420e7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25020250","predicate":"biolink:affects","object":"NCBIGene:5587","sources":[{"id":"urn:uuid:bebdb74a-8dd2-48e4-8b27-2e57dff8d9a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9681","original_object":"UniProtKB:Q15139"}
{"id":"7f0e0bd2-4ae7-4e2c-8e45-f4a209f32f90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1777","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:801213a1-b29c-4194-a480-a3e157f4115e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1777","original_object":"UniProtKB:Q9BPV8"}
{"id":"01429c53-4d6b-470b-b6c3-5acb4e2ef0dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5897","predicate":"biolink:affects","object":"NCBIGene:65096","sources":[{"id":"urn:uuid:5284a332-b0a4-49cc-b63c-9d9e30e56555","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5897","original_object":"UniProtKB:O88917"}
{"id":"1b3aa68d-686a-48ef-bb84-e1dde296ef30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10154248","predicate":"biolink:affects","object":"NCBIGene:2550","sources":[{"id":"urn:uuid:097875f3-8763-4199-9d23-2f6cbf99ec30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1066","original_object":"UniProtKB:Q9UBS5"}
{"id":"22a273c8-a916-4466-8650-8d110f7336ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139350422","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:ecaf83ee-d94c-4d66-8ea0-28e1e6ca2c5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12093","original_object":"UniProtKB:P30530"}
{"id":"6eb6bcd9-5f74-4900-bfca-07a5fd4327b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135899","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:d6857d2c-926f-4429-acb0-c1c0a56aa7bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2213","original_object":"UniProtKB:P47901"}
{"id":"d192752f-b0c5-4a7d-9fb3-2a46ab8ce4a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0ZZF1V8G63","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:8e59e0ac-bd13-42ba-b1f4-1ec6fff940eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9849","original_object":"UniProtKB:P35228"}
{"id":"596c7a86-f397-4939-80ea-06f5d8845572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92234","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:96becd61-bee5-4f11-b807-1c625956b7a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:969","original_object":"UniProtKB:P14416"}
{"id":"918a328e-d975-46b3-a0a2-a2a6bb2b7c1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9953271","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:2196b297-88d0-496b-a354-29e8b128b353","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2663","original_object":"UniProtKB:Q07869"}
{"id":"52a1a380-41a2-4db6-a91b-3845263dd5bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168510451","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:c4dc91d7-b46b-4d20-b92e-189d4fa6faff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12904","original_object":"UniProtKB:O00329"}
{"id":"9391ac1c-598a-48e4-819e-2713f584783c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:1ab8a364-c461-41aa-9c82-1a6fe6c90fe2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P14842"}
{"id":"65a21f3b-4900-4a15-b033-7d0d9c292519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156705214","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:df9db492-e8a1-4b6b-a75d-a9294a61d264","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12118","original_object":"UniProtKB:P31644"}
{"id":"00624979-a50d-497f-9499-48cccea77a80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030528","predicate":"biolink:affects","object":"NCBIGene:3693","sources":[{"id":"urn:uuid:09b4b42f-a2cd-4555-9d24-2b6357484192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10450","original_object":"UniProtKB:P18084"}
{"id":"06c13208-8faf-4b39-9d04-916627a9887c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25110470","predicate":"biolink:affects","object":"NCBIGene:9294","sources":[{"id":"urn:uuid:db013950-7251-4821-b8b7-19921a84fa73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11312","original_object":"UniProtKB:O95136"}
{"id":"100e7046-d352-47ed-88b7-e1be9a9f3761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45483813","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:eab6c854-ed7d-40e7-a784-e190d6e06c77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12065","original_object":"UniProtKB:P08588"}
{"id":"0bc587be-5906-4a26-889d-1bab7f21e017","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1IGV6WTK9I","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:09c0190c-896e-4013-be16-ce6be7faf31c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2173","original_object":"UniProtKB:P30518"}
{"id":"99fe5a37-d445-4b39-85c2-6e2a63c075fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:96265TNH2R","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:a6f0b3b6-3768-4902-bed8-04865921fcac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7940","original_object":"UniProtKB:P42336"}
{"id":"bff0caaa-d7a1-46b7-a63f-290f37319be4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:a0f79fd0-792c-4632-b8d5-fb9e99d3b104","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P28221"}
{"id":"efc549cb-d796-427a-a06a-ced2d2f43764","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:8b28e1e1-5960-4b6d-b347-110f9436473b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P34969"}
{"id":"3fc4cdad-fe52-4d18-a610-299eb83ecdab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:25fe1698-b0dc-405f-a696-afd3659ae1c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P28223"}
{"id":"77991546-60cb-45ad-b7f0-b57c9bff30eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129140","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:216a391b-5538-4103-ba98-71d307d26fdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8583","original_object":"UniProtKB:P08172"}
{"id":"85a51889-dd9d-4934-8f09-3b0da0439986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O1Q96UZ63W","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:6840ea65-5bf4-4e89-b4cc-e359f3e67383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3281","original_object":"UniProtKB:P29275"}
{"id":"1711bfbf-5330-4b37-a6f9-291c1b3f1275","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699459","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:9aaebce7-b43e-470e-82db-3ad868686263","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11198","original_object":"UniProtKB:Q16620"}
{"id":"a87f7efa-c812-4a76-8412-cd5f096a6805","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:26848","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:64ba4e94-34b3-4d25-99aa-bf7cfbb2d875","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4319","original_object":"UniProtKB:Q5XXA6"}
{"id":"8f58c3ba-a062-4d0a-917a-b411947e3cbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:180C9PJ8JT","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:076613ad-61b7-4227-b6a6-43450e98cd75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7418","original_object":"UniProtKB:P15121"}
{"id":"649bc4dc-fe54-4848-86ef-3f51b3fb01e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:100MIC832U","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:82710981-b11f-4f55-a4d5-e357c422c585","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8430","original_object":"UniProtKB:P50406"}
{"id":"caba4275-96c5-4518-8ce5-8b5f17b9f303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46872626","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:8ec7ec8c-793c-4499-8c4b-506599666c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9496","original_object":"UniProtKB:Q9H228"}
{"id":"da3c6922-d84f-49fd-9f19-b0432eae5634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162435223","predicate":"biolink:affects","object":"NCBIGene:1457","sources":[{"id":"urn:uuid:90a650a4-cf1f-430c-99ee-dcf934490a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13949","original_object":"UniProtKB:P68400"}
{"id":"df868001-6f60-47e7-aa2b-0b6201111e98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3921","predicate":"biolink:affects","object":"NCBIGene:16514","sources":[{"id":"urn:uuid:e2fd6f25-9797-4396-bb8a-937c36215c95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2413","original_object":"UniProtKB:Q61743"}
{"id":"bf13c650-881c-4052-8083-ef9d9f0b5284","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95093","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:715772ba-3b00-4369-9480-bba547343ddb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8974","original_object":"UniProtKB:O00329"}
{"id":"fc6b4e3e-abad-42f6-837e-a68831e54c45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1316","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:14bb0cf6-5d90-4352-b5e5-ed7ab7cf38e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1316","original_object":"UniProtKB:Q99705"}
{"id":"a796166f-8617-48f9-b58d-2ced648b12e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25125014","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:c88d5630-3255-4202-a278-6c24dd318be2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8176","original_object":"UniProtKB:P50750"}
{"id":"f313cd58-fb61-4985-8c45-da6ece76b6e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:d24ad5f4-f55c-4021-afd5-fea9caceefdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1641","original_object":"UniProtKB:P41145"}
{"id":"464af5ba-deda-4920-b33c-5a7bf55b228a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91407","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:4558c7f4-440b-4eec-b612-2681b7d159e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7791","original_object":"UniProtKB:P29597"}
{"id":"38bbccca-1e5d-4682-9bde-b20e30cf33cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311285","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:416942e7-5268-42c1-a6ac-2f65ae1daef8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4600","original_object":"UniProtKB:P48067"}
{"id":"e5e9e222-adc7-489c-a80e-eeb6f87ab9ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53325948","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:164938a6-48dd-4d43-9d7c-469b12a17c51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:119","original_object":"UniProtKB:P28221"}
{"id":"c3589493-044e-4269-874d-1531a91d7bf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:165313","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:7de8ade3-7ea0-4574-8a07-501b313730eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1947","original_object":"UniProtKB:P43116"}
{"id":"4204d788-efe8-473e-bec5-1fad102da554","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27965","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:8ccb4d40-1950-417d-b568-4f53993c2b33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8981","original_object":"UniProtKB:P35367"}
{"id":"bafa85e8-a574-46af-bdb0-e183cc701839","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44398718","predicate":"biolink:affects","object":"NCBIGene:27163","sources":[{"id":"urn:uuid:1e841b51-e92f-4336-90b5-2459bde7730d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5161","original_object":"UniProtKB:Q02083"}
{"id":"2d48efc8-51b5-49b2-93a3-84213e8559bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2273","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:b74f4d63-94a6-48e0-8344-f88e62259902","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2273","original_object":"UniProtKB:P32241"}
{"id":"3b6d75bd-a25b-4c0f-b910-3d2df33a24e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22359367","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:2168fb5f-11a2-4ca7-abaa-537b1020730f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4107","original_object":"UniProtKB:A8MPY1"}
{"id":"3cc6120e-032a-4864-8c19-d541f2cb0616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9868452","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:c03c67f9-90a1-4cfa-b936-52ba57f2227d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:129","original_object":"UniProtKB:P28223"}
{"id":"4e41da4e-a4c4-4202-b53f-d95fa34ed69a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:a4001a51-6df2-4947-bec8-fa1c64d81bd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4075","original_object":"UniProtKB:P39086"}
{"id":"f9177b72-c0b3-4355-8032-93318c2f02d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:187796","predicate":"biolink:affects","object":"NCBIGene:193034","sources":[{"id":"urn:uuid:57bb5ec9-f5f1-4791-bf3e-81fd493121c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2485","original_object":"UniProtKB:Q704Y3"}
{"id":"95d97fc1-37df-4637-bb5c-215a215ceb87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31397","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:5b00cb0b-5c33-4728-82c1-e07ab2098813","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7469","original_object":"UniProtKB:P04150"}
{"id":"b28cebb9-bae1-4865-9840-6f724917aa98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132427686","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:d904614e-17eb-4a4a-99c1-7fbf5a54836f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9759","original_object":"UniProtKB:P41145"}
{"id":"17437690-bcb3-4d08-a307-76002cc13fea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85966","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:47bf5f34-aeff-4214-be47-2198825d2d1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2357","original_object":"UniProtKB:O88704"}
{"id":"c893010e-9a54-40df-9000-32065e043653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:bedacd3a-597f-4170-87af-942cce212dbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P14416"}
{"id":"b291f76b-eafa-4ce8-af39-b3c52142f039","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N03P021J8","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:964f5609-e0d5-4e89-b123-d79221f8cc7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7954","original_object":"UniProtKB:P52333"}
{"id":"93187377-b32a-4c1a-8737-5635290cf56b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311186","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:5cd068f0-909d-47c7-a0c4-cc45ce6d2613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1266","original_object":"UniProtKB:Q9QYN8"}
{"id":"8b033920-9181-4e69-a6c3-cd6e3f17e4ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:10db722b-c9a5-4ef9-af0a-c1c6bcdda2bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P29275"}
{"id":"323dcb41-0d85-4ac3-91bd-a6e86f0e9ec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817494","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:80652da5-40f1-471b-bb3e-1df1a5f4c43a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6248","original_object":"UniProtKB:P25090"}
{"id":"d6a3245a-50fc-458c-b053-4e411d01deab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28051","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:c1006b5c-4e2f-45d6-8f0e-65abe5405ee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2626","original_object":"UniProtKB:Q9UQD0"}
{"id":"ce1d3959-ccde-4d8f-b9ad-bc35bb8bb72f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:9ee56831-21bc-4b0e-acbe-7d833f06c842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:Q13258"}
{"id":"94bf1fba-6979-49f1-9e07-28a1c38f8837","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL445816","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:ae3c058f-aff6-4366-b17e-674ab3cb113b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2194","original_object":"UniProtKB:P37288"}
{"id":"9aaddcbc-68bc-41ef-bbc8-b8de3424ee9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6313","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:beac155d-3f5c-4e6e-8e42-28e17359c5d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6313","original_object":"UniProtKB:P35414"}
{"id":"5e307525-1fe2-45a7-8f92-9b44f4e398d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1500","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:74b5714a-935a-4ee5-93ed-03f42fb69f10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1500","original_object":"UniProtKB:P48145"}
{"id":"df7610a2-6473-4cc7-9b44-2e761c127d9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13852","predicate":"biolink:affects","object":"NCBIGene:1589","sources":[{"id":"urn:uuid:e0256395-c67e-43b3-967f-246a9d6efc9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13852","original_object":"UniProtKB:P08686"}
{"id":"d1ac5e5c-57b7-4632-8361-efb405478caa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827354","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:34ed0d91-776d-4e03-a19a-881b1e962ac5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8381","original_object":"UniProtKB:Q16581"}
{"id":"2b068067-1503-4f91-ad56-e9db7356b2e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:5638faa9-3784-4bcd-b071-69dedaab7793","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P28221"}
{"id":"0d75ab7f-3929-4879-b607-041cb881c2c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162760083","predicate":"biolink:affects","object":"NCBIGene:1453","sources":[{"id":"urn:uuid:115462ba-64f2-4f25-ae24-617f5c8d7aa1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13345","original_object":"UniProtKB:P48730"}
{"id":"f78bf107-f65a-49b5-86a3-a65700d71cf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163388532","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:47d9ca0b-d919-48e1-b054-f714f7cad04c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12278","original_object":"UniProtKB:P00533"}
{"id":"7a54b6d5-45b7-4ec0-8a33-ae4d55d50a21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679540","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:b0078978-d947-427b-bc59-8295e0983987","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11856","original_object":"UniProtKB:Q8NHX9"}
{"id":"83572fcd-a36f-4ca7-8f27-126be6739c84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64131","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:c949ad12-9297-4b22-923a-77ef09f5375e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:73","original_object":"UniProtKB:P25100"}
{"id":"35f864ba-2354-44fa-bab8-b78d1481f1c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5015","predicate":"biolink:affects","object":"NCBIGene:16847","sources":[{"id":"urn:uuid:e054c930-9b7d-420e-9e5c-671b424bc4c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5015","original_object":"UniProtKB:P48356"}
{"id":"dd6bb396-f8c7-4be3-9434-b181bb4c423a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3889","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:d9b651a3-4e37-418b-8680-99beacf31925","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3889","original_object":"UniProtKB:P21729"}
{"id":"870e6abb-59e3-4250-97fc-57ae21e69104","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2084","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:12acffe7-2219-4f57-8a60-bfc212b3a325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2084","original_object":"UniProtKB:P30938"}
{"id":"dc2530eb-10e1-4a86-8293-45873fea5522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90645598","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:3fdc16b2-ddc3-49ad-addb-3c17fca6c361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13155","original_object":"UniProtKB:P23944"}
{"id":"c6756c66-747c-4a47-a389-32851a72c3b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58968","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:351a76b9-bafd-48a0-9892-17cd4c8f27a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6274","original_object":"UniProtKB:Q6RI86"}
{"id":"aa32b2a4-b482-4dfb-8158-12a91f97926d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:3737","sources":[{"id":"urn:uuid:cc91de14-8264-4422-af6a-0283231031ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2364","original_object":"UniProtKB:P16389"}
{"id":"0807e30a-7b67-4bb8-8eac-4ee2c092d1ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25149244","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:231a1278-6bf3-494a-877e-a8f95b9c8f17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1199","original_object":"UniProtKB:P35367"}
{"id":"2928bb50-09a9-4990-b031-48dec8d6e02c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101688584","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:2ea8da3c-64b6-4908-bc0c-c72016add395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10227","original_object":"UniProtKB:Q16581"}
{"id":"5aa80642-182e-4de7-9e3d-855123563bea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:85473309","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:f059fc06-4863-488f-8feb-4fe5693cb28c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10286","original_object":"UniProtKB:Q9UBN4"}
{"id":"93d269b5-43e5-45d3-b0f2-fe29ac728da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101096","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:b97be4bd-ce7f-4f5d-9b53-4166ac697bae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6814","original_object":"UniProtKB:Q9ULX7"}
{"id":"59d26173-374d-4132-b0ae-4adb4518c3ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15118529","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:22a9e451-256c-4953-990f-59754f812cb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:340","original_object":"UniProtKB:P20309"}
{"id":"ab2afaa7-cdbd-4ba4-98cd-ed793fa03ba5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2432","predicate":"biolink:affects","object":"NCBIGene:76856","sources":[{"id":"urn:uuid:58601c9a-69ab-43eb-bf38-15897684b86d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2432","original_object":"UniProtKB:Q80W99"}
{"id":"de6e0bfc-870c-44f4-a398-ce00a814fd27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JTZ51LIXN4","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:4691818e-cf90-432c-b9e5-9a3ab0ab0b82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11413","original_object":"UniProtKB:P07947"}
{"id":"849bce3a-b9ec-4b4d-9cd1-85764254b643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1527","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:1014b486-84b7-4d26-a714-8c3efe7c1d4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1527","original_object":"UniProtKB:Q63447"}
{"id":"76c58313-e56d-41c7-b28a-6190fa911cc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145704693","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:0db5edee-b872-4c0e-a381-baabb8460ae1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10751","original_object":"UniProtKB:P37231"}
{"id":"1b60c2a3-a404-49a0-8db8-5e94c8e2c278","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CY3QT94KWP","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:3e665cd3-421e-404a-be36-15002be10b75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8200","original_object":"UniProtKB:P56726"}
{"id":"f9a9568c-78f8-4cb7-8ceb-924a598fb579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229800","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:5d8d8a76-905a-4c1b-b33c-da259763eb10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2882","original_object":"UniProtKB:P06401"}
{"id":"e460f8f2-4590-4f8a-bb3b-6f6e5cabe91f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25229528","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:992ba953-552e-4b36-896c-5e701ecf49f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8220","original_object":"UniProtKB:P06213"}
{"id":"40727f67-68f6-4d73-9007-79bcde422731","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93463","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:2ad76918-cb5b-4769-aa82-6d2dcc7c2f36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2114","original_object":"UniProtKB:P21452"}
{"id":"959701a0-66f5-4e7d-b58f-98bd4964e9b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:29a9cd73-8005-4cd7-950d-55cbce2877ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P30875"}
{"id":"9bfc9d5d-8d08-42d4-af41-f493fa6b317c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:89872","sources":[{"id":"urn:uuid:54a2bdd4-1d1e-4244-b07e-25b9202ec32d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:Q96PS8"}
{"id":"e714af64-d560-4083-b097-7403c20e2aa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94760","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:e1be2fa6-c279-492a-bc39-c0dd69e5226b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7849","original_object":"UniProtKB:P10275"}
{"id":"e98f9e88-d4d1-4391-902b-17feaa96701e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17939","predicate":"biolink:affects","object":"NCBIGene:9520","sources":[{"id":"urn:uuid:d251a801-072f-4392-978a-c9a716f4fa2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13311","original_object":"UniProtKB:P55786"}
{"id":"bbcb41c6-8793-4003-8dd8-e91d4932ee29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232811","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:3cd3f01c-6fa7-45f6-9471-0e1411b34e96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12074","original_object":"UniProtKB:P50613"}
{"id":"1012e300-1e02-4ff6-9830-db73c1a56cfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93201","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:ff1c8624-b800-499e-90c7-e53a49dfb7a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4347","original_object":"UniProtKB:P34903"}
{"id":"c42137b5-684c-4f71-8571-a225a1fe2135","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:f5fcf31e-ea62-4fa9-a92c-f4ed4b523e9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:P24941"}
{"id":"81ffcf84-b37a-4e27-bbe7-9d46b0533047","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3715238","predicate":"biolink:affects","object":"NCBIGene:7786","sources":[{"id":"urn:uuid:7cd5040c-e0b7-4ddf-a94f-4a1d33fe4b84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9990","original_object":"UniProtKB:Q12852"}
{"id":"237fc2e7-2b12-40a8-aed1-fca6be9fe4c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688563","predicate":"biolink:affects","object":"NCBIGene:10420","sources":[{"id":"urn:uuid:dac1300c-981f-4cbc-9318-e15ab33174bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8119","original_object":"UniProtKB:Q96S53"}
{"id":"7aa21124-93b6-49f9-bd76-05bcb0e668c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567262","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:0a56f5d5-fb5d-47bf-a012-b8d0a4db617b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10406","original_object":"UniProtKB:O43353"}
{"id":"56824cec-bde8-40b0-97d6-b22057f70f32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131502","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:9ee4e6d6-6b09-4c52-9245-2a8e249325c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1878","original_object":"UniProtKB:Q13258"}
{"id":"d7c9109d-3dbd-4ac8-b427-fc661880798d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452040","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:f706fbec-8ba1-46c9-9b39-2b41ca7a461c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9190","original_object":"UniProtKB:P14416"}
{"id":"360e4e6a-155a-4b95-981a-5cae1933ce3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9838148","predicate":"biolink:affects","object":"NCBIGene:14815","sources":[{"id":"urn:uuid:9d1f4bac-ce4d-4a1f-949b-16a77758bcfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11317","original_object":"UniProtKB:P06537"}
{"id":"99f5c9d7-3eab-4ac3-a123-858cc4b5317e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83656","predicate":"biolink:affects","object":"NCBIGene:3326","sources":[{"id":"urn:uuid:0b4331bc-5165-47df-9786-c32d0e199707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9261","original_object":"UniProtKB:P08238"}
{"id":"9c405025-1762-4677-afe2-ec48b38c0272","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2191","predicate":"biolink:affects","object":"NCBIGene:25107","sources":[{"id":"urn:uuid:970783d8-53c4-4db3-85fb-d24d0f656777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2191","original_object":"UniProtKB:P30560"}
{"id":"526149b2-5517-40ca-9918-3ac13a12dfa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2IOB2M82HY","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:69c26000-9bb4-4d5b-bdeb-ece40c7ba391","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9444","original_object":"UniProtKB:P50406"}
{"id":"f4912c83-8deb-43af-837b-2d4bfc217d3a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5130","predicate":"biolink:affects","object":"NCBIGene:79123","sources":[{"id":"urn:uuid:6f2f2118-b6fe-4f63-95e5-d23e39844110","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4194","original_object":"UniProtKB:P55926"}
{"id":"0e5e4644-8100-4c33-b866-8b56b26044a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:5566","sources":[{"id":"urn:uuid:70093247-0bac-4722-877d-4eae9d87ad21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:P17612"}
{"id":"0678a61f-a594-4abf-9177-dd530a2039b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68159303","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:ab86e31e-e917-4960-b0c2-b1ef1995077b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10642","original_object":"UniProtKB:P51449"}
{"id":"db81ea4e-674a-4609-8ae3-effba1b54a8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DIH95YP7J3","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:be1d1bf5-697f-4b0a-8501-36fc6c7b87b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9473","original_object":"UniProtKB:P41180"}
{"id":"b997b2eb-fe6e-4ced-be8f-8c3b22cf0bca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126843232","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:27b4a6bb-9fca-4beb-94fa-8f73a7a7f79f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13053","original_object":"UniProtKB:P32249"}
{"id":"98fe22f6-c3d8-4c49-835e-cb6691392f65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:879OVM0Y1S","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:bcd2321e-7a06-4db8-a414-f6ff865d566f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10043","original_object":"UniProtKB:Q9NQS5"}
{"id":"d957bf51-c2d6-4940-b5cd-da43ae5bea74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7034","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:7e5eb8cb-a943-4ea9-8296-7fc7e200b373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3996","original_object":"UniProtKB:Q9UGM1"}
{"id":"12975683-03d3-446e-b332-ea6f38d5e7b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321154","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:4eec22d6-fbd1-47a5-8d60-b61c6a8308f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10146","original_object":"UniProtKB:P61073"}
{"id":"8708f010-35d5-4686-b0a1-41c3577491b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194337","predicate":"biolink:affects","object":"NCBIGene:117144","sources":[{"id":"urn:uuid:f80c3c45-b113-455a-b93f-cfca34b67aeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4269","original_object":"UniProtKB:Q8NEC5"}
{"id":"4c9f2c2a-38ea-4ffb-ad8f-b8d045362997","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91938093","predicate":"biolink:affects","object":"NCBIGene:5565","sources":[{"id":"urn:uuid:845eb696-5d06-4480-abcf-47fac7d01825","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8821","original_object":"UniProtKB:O43741"}
{"id":"78be1008-de8d-48a8-aade-ca92f23f9171","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:78b627b3-55c5-4f34-8a2c-7130a6c0cfc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:P42345"}
{"id":"cfa661a7-c8ab-4549-b920-172ad851e35a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91107","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:0e7b5913-9f43-47fb-8608-daea1c9b8fd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8019","original_object":"UniProtKB:P49841"}
{"id":"a0c585ff-05d4-4001-ab57-2225360a5dd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91332","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:8b7f3dda-ed05-487e-9e3d-24091b3c8922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9356","original_object":"UniProtKB:Q15418"}
{"id":"3e474249-8b3b-4424-84b7-3983cb47885a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:e3e8e739-73b6-4e0d-82b7-189e159f1ee7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P29274"}
{"id":"6ea86666-0a0d-4f02-9cf4-d491d5336e9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16167454","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:8c034f0c-af0c-482a-839b-38a8866602b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1298","original_object":"UniProtKB:Q99705"}
{"id":"95a0b4ac-6b66-4cbf-9a3b-4e86268d01ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177502","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:0a9b1200-2708-46db-bd96-1760a89703d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9733","original_object":"UniProtKB:P18031"}
{"id":"71e0d938-96bb-4143-91d6-32d9c28c338b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44453784","predicate":"biolink:affects","object":"NCBIGene:817","sources":[{"id":"urn:uuid:23b17f5a-d8c2-46bc-85af-b35a7bc8be19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8157","original_object":"UniProtKB:Q13557"}
{"id":"374737d9-2628-4254-a11f-98e1cb4b3606","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15650","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:ee24f190-b0e4-4dd8-9d8d-5c1139bed83f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3352","original_object":"UniProtKB:Q9Y271"}
{"id":"a0bfaa9a-d824-4f05-81d2-2b430ca4615c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5170657","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:9f0865b1-0ad3-4621-a296-8a9fcca93dec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11836","original_object":"UniProtKB:P35414"}
{"id":"4196ba89-55f3-4fb8-a012-ce325f6a59e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:37e1cce4-0833-4348-a714-669122a57461","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:P48736"}
{"id":"96453161-f951-4f25-ba2c-329b09b1c978","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73222","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:b2928df8-7896-4b71-943e-a6ae9b932ea4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12498","original_object":"UniProtKB:P59537"}
{"id":"0e002e5c-dd32-4e2d-8fb0-a29f40e312a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90217","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:fa058dbc-8f52-4edf-a273-0c00010e70ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5658","original_object":"UniProtKB:P07949"}
{"id":"e0fec6be-1b43-4489-8e68-f2a345ff9f36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:13844","sources":[{"id":"urn:uuid:e535890a-e45b-4b5f-8e20-ede96e3ca121","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P54763"}
{"id":"d637cbfe-86f9-43b1-b81c-e72aa0ecc0bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9945530","predicate":"biolink:affects","object":"NCBIGene:81672","sources":[{"id":"urn:uuid:393a801a-aa6c-426c-a1c9-bfcf01075dc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3341","original_object":"UniProtKB:P35400"}
{"id":"d93c6e89-814c-41be-8733-754597388c68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27485","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:cda5a610-36ce-4555-a301-c1faa3263fd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1885","original_object":"UniProtKB:Q13258"}
{"id":"4c1846ce-b3d8-49bb-9fc6-ca27e2bb84bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2563","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:f76922b9-a095-4484-a5b1-70c98db36d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2563","original_object":"UniProtKB:P63142"}
{"id":"a6527748-7d1a-42ec-8c2e-e4afcd552478","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:2233a112-9743-4800-a91a-214bff41dc73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P08908"}
{"id":"30d3d028-c512-488b-9938-74b0bb5ec495","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44452237","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:8fac3232-2258-4fb2-b426-39ed61284ca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2980","original_object":"UniProtKB:P04035"}
{"id":"c182dacf-07f2-4a19-a1ad-d68d4eeded30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8044","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:ad6deca8-b860-42e2-bfc8-1f9a5d456cdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8044","original_object":"UniProtKB:O14757"}
{"id":"d1df0b67-bfc6-4c60-9fd4-c38780643128","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:573","predicate":"biolink:affects","object":"NCBIGene:27202","sources":[{"id":"urn:uuid:df3c86b1-bdda-4a99-95bc-bb943fd44c91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:573","original_object":"UniProtKB:Q9P296"}
{"id":"cf608ab6-d83a-41df-be68-a9c354f11b58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92874","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:7d3ef9f7-38aa-4f66-8b00-d9a15874401b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:966","original_object":"UniProtKB:P35462"}
{"id":"f16764a0-9418-4108-b3c5-95714d0e6c15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4YL3GT1EV9","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:f4de29b5-73b4-489e-bc3a-c97890fa598b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3473","original_object":"UniProtKB:P25103"}
{"id":"8465acd6-1597-49a9-9fae-b5949baf1d06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2266","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:16f200c0-3580-43da-9f75-b4422f88e514","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2266","original_object":"UniProtKB:P41587"}
{"id":"35f5e65f-8b3a-45ae-9418-84c175682f4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118660867","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:e55e4f48-72f3-41a5-8a77-ee611ebab238","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9170","original_object":"UniProtKB:P49336"}
{"id":"da80de6a-06a6-417a-8b5e-a517bf207768","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4644453","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:25bb7c75-ad6d-4817-8534-a36881e1072a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9157","original_object":"UniProtKB:P35372"}
{"id":"ccc793c7-c4d6-4701-9144-91b3f4f5f1b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:4514b0fe-5b49-4e8d-8d9c-c3b74e69e621","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P14416"}
{"id":"c8eeb9f9-2630-45fe-88cc-bb39e56ebd18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139035063","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:db2b9446-4e76-42c7-ba36-5023c3fdc7cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10494","original_object":"UniProtKB:P34913"}
{"id":"c332605c-b901-4007-8733-2eb4ade62519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63681","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:46103e49-27eb-49de-9aa1-a27df04ab347","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4252","original_object":"UniProtKB:P29274"}
{"id":"33c035aa-dce7-4bfa-9932-ec732391ad54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311320","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:0d0dbda8-24d4-4221-a503-50e9754c2971","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1572","original_object":"UniProtKB:O95665"}
{"id":"75ea2ecd-258d-48cd-b7e4-a5328338ac98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34725","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:cfb09357-d138-4aca-a2cc-b24f5a0fef17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2403","original_object":"UniProtKB:Q12879"}
{"id":"cdfe1c8c-68a5-4301-a4f8-3c9831d5d0ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118124117","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:5299c159-e69b-4705-b701-e70fe29ad0c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12305","original_object":"UniProtKB:P11229"}
{"id":"c4052c26-d811-4ab0-be51-94d3f8b41971","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1X0H7WEC5D","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:79a6ff4f-22f6-4706-be7a-a6d6662a391e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8896","original_object":"UniProtKB:P23944"}
{"id":"46af6523-8b81-4256-828a-32d6a3a06615","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F3YMY7783P","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:841abd3c-5980-491d-ab16-aa52d7adff95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11699","original_object":"UniProtKB:O00329"}
{"id":"fcb4af24-0f9d-43b4-8d46-e2b6a382315d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:8bff4eef-4d42-46a4-b802-099cc0a9d7ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P36888"}
{"id":"eb7bb54e-2e49-42e1-846e-841ec273cf03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22200891","predicate":"biolink:affects","object":"NCBIGene:11069","sources":[{"id":"urn:uuid:f7ea514e-5bc2-482d-ba4b-26ee6187fa75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6556","original_object":"UniProtKB:Q8WZA2"}
{"id":"5ccb4cf2-fc7a-41f2-be2c-8477e85a55d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1048","predicate":"biolink:affects","object":"NCBIGene:14289","sources":[{"id":"urn:uuid:612bf75f-89f9-438d-b408-a6fe8bdc0ab3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1048","original_object":"UniProtKB:O88536"}
{"id":"f8fa3311-83a2-4109-a028-c832ba0f08a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58368068","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:3c1b5a39-f21e-4bfb-aaa9-7f70ab064d9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6410","original_object":"UniProtKB:P41594"}
{"id":"7e253bc5-a6a6-43cd-a33f-2dec4b46e7fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10354234","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:2ec592f6-cbae-4c0c-864b-1a325d4c224e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5846","original_object":"UniProtKB:Q9NQS5"}
{"id":"8dfa45bd-3a8e-4a30-9aa5-2f7291a66043","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0DXG50I4WD","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:7dd24777-1c57-45ec-a6d9-c7cd34166e06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12721","original_object":"UniProtKB:P31749"}
{"id":"7b93a5ec-8796-4f9a-acbd-c932d4dd3808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:56a3f191-0f6e-4547-ba96-9d2331f68af1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P32304"}
{"id":"eb99a8d1-89b2-4791-b967-e1cf6f36011c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KF50235Q04","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:94fd52e0-ccd3-4513-861a-1dc7fb10ebdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7346","original_object":"UniProtKB:P35367"}
{"id":"4b4ec16d-f959-4502-9386-01f1d8a10280","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195541","predicate":"biolink:affects","object":"NCBIGene:29415","sources":[{"id":"urn:uuid:6cda7aff-7091-4847-bb2a-843cb28261e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2917","original_object":"UniProtKB:P47752"}
{"id":"8c921ee8-a27e-4f32-b72e-8f5176a6a682","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135412420","predicate":"biolink:affects","object":"NCBIGene:4357","sources":[{"id":"urn:uuid:bc163ae8-3eec-49f9-a846-41ee0ccd1de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10210","original_object":"UniProtKB:P25325"}
{"id":"eac01c12-5460-4bbc-b90b-dd4ea1ef1f11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6979053","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:a63e8b4c-b74b-4d0e-93ea-e6d565f407b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:288","original_object":"UniProtKB:P08912"}
{"id":"0b36baeb-e2c1-4e94-8709-b4c2ca3d7e35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566612","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:7cb801dd-8fee-4716-be74-7be634789114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8172","original_object":"UniProtKB:Q08881"}
{"id":"d74ec865-33b7-4601-9aad-a415b671fbcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8453","predicate":"biolink:affects","object":"NCBIGene:4854","sources":[{"id":"urn:uuid:29af83dc-1a18-4e8a-ad0d-f9d2c4e34e65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8453","original_object":"UniProtKB:Q9UM47"}
{"id":"4ce556db-62cd-46e6-b0ca-dc9e5bb75f10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:0cd3d370-8bc4-42f0-8148-bdf552754e83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:Q01668"}
{"id":"52d4758f-073d-4177-885e-91e39ab5d34c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11910","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:0447c942-582b-4e14-9495-27c47bf18dba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11910","original_object":"UniProtKB:Q9NSD7"}
{"id":"fa832b02-542a-495a-b1c1-563255f8ecb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:81645","sources":[{"id":"urn:uuid:d976660d-b54a-45aa-9a73-f6bfbd6b20ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P10980"}
{"id":"5fd1632b-088e-4879-90f1-003b8cf252bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2008","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:eb803a61-3183-402c-805e-42f447d5d700","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2008","original_object":"UniProtKB:P32745"}
{"id":"a9d9a7b5-7362-479a-bbac-3b6c9aa4738b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:19511","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:b675c386-41bd-4b30-a5af-f057b73231fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2910","original_object":"UniProtKB:Q9UBY5"}
{"id":"a4eebc2d-09c6-42fe-a56c-c7c53609c7d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:df6e01b8-fab5-4a22-9f23-ce02654c868f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P50613"}
{"id":"02c1deef-14e3-44e8-b2de-8fc9a80681e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9843337","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:862efa5e-64ba-4faa-a40b-293c19c4270f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12545","original_object":"UniProtKB:Q8NER1"}
{"id":"bd2e8f9a-2417-42a8-8a7b-5359929ac3cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821941","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:1b930677-7ced-41ad-a7c6-98383350516c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9099","original_object":"UniProtKB:P31645"}
{"id":"6b5dacf3-be64-490d-8a11-f9b017650ef1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FA554TW3UP","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:0c863864-138f-438c-af95-9ef7a1bb6ad2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9004","original_object":"UniProtKB:P41143"}
{"id":"d71ed103-3966-48d2-819f-492e7f3a6510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23627211","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:f44c69a1-7d34-4631-b22a-ac56673004da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8399","original_object":"UniProtKB:P56817"}
{"id":"0f90345f-e99c-47e5-ba47-4e2a63679acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2Y3T5IF01Z","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:8ddc1eb1-d158-4455-b6f8-fc702e796b46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11583","original_object":"UniProtKB:Q15116"}
{"id":"a05ce9c4-ada1-465e-a954-6f620eda5a2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6QTJ9P2NYT","predicate":"biolink:affects","object":"NCBIGene:8694","sources":[{"id":"urn:uuid:1ea1ccc2-3fd8-41fc-938c-d0510d6b0cd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7827","original_object":"UniProtKB:O75907"}
{"id":"33b9c9ee-3f05-4623-adfb-79891b948dca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SE2KH7T06F","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:cdd09787-0101-4fb7-bcf3-1eb01ec70ab6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5082","original_object":"UniProtKB:P04626"}
{"id":"19e14125-41bf-4dec-81b5-851a60d40346","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:3756","sources":[{"id":"urn:uuid:13ec07f3-6b0b-47e8-9dd2-c4289bd05d6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:O95259"}
{"id":"eb677922-4f8e-4d48-b914-a3dfd01379f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:95286403-86b3-43a7-bb47-e8f4e36b583b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P34969"}
{"id":"b6f28ea9-6138-44dd-91e3-89c836d2e1d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71529752","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:31787fe9-4cb8-4e2f-8407-c091cc2631b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8165","original_object":"UniProtKB:Q13627"}
{"id":"9f4773c3-7610-40ea-8fe2-5fcc0c5cb8d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3594","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:f22379fa-10a8-49a1-856e-9e21def2dc1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3594","original_object":"UniProtKB:O43603"}
{"id":"87b1010b-7b08-43b6-bd29-f06a8b60b6ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0TJ631J0KP","predicate":"biolink:affects","object":"NCBIGene:50488","sources":[{"id":"urn:uuid:ed5c2f4f-9151-4e54-9558-888e4cb9681c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8179","original_object":"UniProtKB:Q8N4C8"}
{"id":"6925cfdf-2800-4419-9227-1278b588ead2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QMS40680K6","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:627eed3c-a1ec-4f24-8f4c-a7709f2e52eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6954","original_object":"UniProtKB:P21802"}
{"id":"d8a71f4e-bd49-4982-a261-e028031e2077","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44310146","predicate":"biolink:affects","object":"NCBIGene:3002","sources":[{"id":"urn:uuid:5b8bc90c-345a-4458-936a-120ccc5f8f60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8650","original_object":"UniProtKB:P10144"}
{"id":"bc045391-73bd-4381-b7d2-4ef6a0ed9633","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:56164","sources":[{"id":"urn:uuid:a8b76db3-9454-4e67-8227-8efe8328c54e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:Q9BXU1"}
{"id":"3722ecd9-8c03-45c3-bd64-2172d7f6b673","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16725999","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:12a3cc78-c666-4597-9af9-86f6e01abb15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6985","original_object":"UniProtKB:Q92633"}
{"id":"a6d300ff-b839-4c82-ad2f-44a87019bb97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138319685","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:e38f803a-7932-48bb-84c2-42b9de6ee78d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12534","original_object":"UniProtKB:Q9Y210"}
{"id":"268539b2-4093-427c-ade0-fcbe375787fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118893637","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:733709c7-735c-411c-a2e9-b155e14f931e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13218","original_object":"UniProtKB:P21802"}
{"id":"8f8fdf16-6df4-4204-b4e4-d9ffa305e1f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24893979","predicate":"biolink:affects","object":"NCBIGene:114862","sources":[{"id":"urn:uuid:dca6cb91-2912-449c-92c3-4dfae02a610d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7723","original_object":"UniProtKB:Q9EQ60"}
{"id":"f349883c-3c55-4e33-87a6-676a6747bbff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7494","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:12e0737c-0d19-4fc0-9054-e630b2c3a275","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7247","original_object":"UniProtKB:P08684"}
{"id":"8d3170f8-575e-4c6b-b3b4-90157c0e8de7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46937420","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:47bc932e-dbb1-443c-9e8c-8eb91b9a8da7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6260","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"77b70fe2-699a-415e-9c17-f761fdb69819","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16584","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:f12abe4c-72e8-4a36-81c7-1b731bd290fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3048","original_object":"UniProtKB:P14324"}
{"id":"2152ec42-5788-4abe-99e1-5a5f486d19d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10221256","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:7688416f-d10b-466c-a489-ef5ea3169986","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:447","original_object":"UniProtKB:P29275"}
{"id":"47d34c6c-23af-4dd7-b271-ccbbc394afd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11646823","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:4aa60b21-4d4a-482a-932a-003e9777bed0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6409","original_object":"UniProtKB:P41594"}
{"id":"b523807f-bcca-4e22-9cc9-e6dd5ffd55e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50996844","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:22af2a6f-2e15-4c96-91dc-2f34e62014a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7805","original_object":"UniProtKB:P49768"}
{"id":"7ad1a988-731a-4e7a-9fde-b12c7695ff71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71548412","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:ce3cca29-8b7b-4abb-a757-9de810bc6f00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9879","original_object":"UniProtKB:Q9H3N8"}
{"id":"872b9a71-7108-493c-8fc7-10a11a7f8fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JZK8P9AG86","predicate":"biolink:affects","object":"NCBIGene:7512","sources":[{"id":"urn:uuid:3051b46e-1ec7-4b20-8c77-7263326711ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8803","original_object":"UniProtKB:O43895"}
{"id":"144ce072-308c-4b4e-a7a7-fcca7a47aca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44123300","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:07862032-0ddf-4d88-a353-2dda6bb3a2d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1714","original_object":"UniProtKB:Q96G91"}
{"id":"7dadde33-807a-45e4-97da-ff8724d576ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46862051","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:4a5c0e8e-3925-49e2-b07c-abb472cdd6b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11438","original_object":"UniProtKB:Q9UKP6"}
{"id":"bbcda8a5-44da-45ba-8ea6-456b58a67ff2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10894911","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:b8d77763-70ce-442f-b137-3f015852a05f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11499","original_object":"UniProtKB:P08173"}
{"id":"82e58338-710f-4f95-ad0e-d2b46da3d740","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827342","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:54ff7455-2804-4171-a4b1-dfc3c9ca907d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1769","original_object":"UniProtKB:Q9H244"}
{"id":"1d210692-5517-4585-af06-68507c3e20e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:181441","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:4820bd03-4a02-411e-a340-6909d84d8111","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12441","original_object":"UniProtKB:Q9NYV8"}
{"id":"b8cd137d-9a9e-48cc-8694-a6644a78780e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4402318","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:f92bd2d5-61b5-4370-bcc9-c3a1f9b32d07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10272","original_object":"UniProtKB:P21554"}
{"id":"8255c1d8-d220-4f5b-8b4a-b93cf4e6146f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U65F5M6BD5","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:a7d9992c-e393-4495-82c6-06da34c02373","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10628","original_object":"UniProtKB:P00533"}
{"id":"1460fa0b-b7b6-4650-a46f-fbeb5f1f39de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6456","predicate":"biolink:affects","object":"NCBIGene:29571","sources":[{"id":"urn:uuid:3aaff464-4bd6-45b9-9f45-c3e2a4fa09ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2623","original_object":"UniProtKB:Q62968"}
{"id":"43a8cc87-4c35-4c56-9c11-d1349af9cfb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2212","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:e8ac8e51-03ba-442d-a51c-f7c5583a5f19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2212","original_object":"UniProtKB:P47901"}
{"id":"d304edea-c942-4f9d-856e-4ea9bb686de3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CER0OPG92L","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:e7342388-d9ad-4bd7-8ffb-da131afa9126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10044","original_object":"UniProtKB:P52333"}
{"id":"14613f9c-b802-47c6-a893-b948bab6d9c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2896","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:9eae055d-4b24-49f5-a47b-3669970a35ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2603","original_object":"UniProtKB:P35367"}
{"id":"34de3076-30d8-4b5b-a465-185f5d33bae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:6553","sources":[{"id":"urn:uuid:d4c064f5-dd44-40e2-b270-6f69d56c1aa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q14940"}
{"id":"e8a030d1-c1ef-45cd-abf9-e5ea1dd589ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71711862","predicate":"biolink:affects","object":"NCBIGene:20274","sources":[{"id":"urn:uuid:b0c33c10-e735-4f19-a37a-60c3d5f088e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11023","original_object":"UniProtKB:Q62205"}
{"id":"cc111620-57aa-4732-9bb8-626869b8a66d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130395","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:9715a0a3-d178-49ae-96c0-a31c069bcca1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:853","original_object":"UniProtKB:P61073"}
{"id":"c0025856-072b-46c2-8e93-bb08914a0ce4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4697","predicate":"biolink:affects","object":"NCBIGene:16531","sources":[{"id":"urn:uuid:0ab76f00-5fc0-4756-9c3e-732bd5095b07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2309","original_object":"UniProtKB:Q08460"}
{"id":"d38f5668-c597-49d3-ace0-8ef73a987969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102216630","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:da43294b-47a5-415b-8644-769553674c83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10287","original_object":"UniProtKB:Q9UL62"}
{"id":"87a13812-071c-43a8-8755-51518962085d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92477","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:e6c49c69-01fb-4226-bafb-f8e6f6c8e393","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:255","original_object":"UniProtKB:Q13639"}
{"id":"293c7454-bb89-4230-905c-7bf8da9d9eaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13880","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:c96ede6d-3be8-4be4-884a-beedc1b681c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13880","original_object":"UniProtKB:P00533"}
{"id":"e39a2949-519a-4211-a47f-1eb0e3963691","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59173","predicate":"biolink:affects","object":"NCBIGene:2147","sources":[{"id":"urn:uuid:0f147c4b-d470-487a-bc1c-fc40a0c87534","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6470","original_object":"UniProtKB:P00734"}
{"id":"422296ce-b5ed-46c6-956c-879fcd1afafb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66561876","predicate":"biolink:affects","object":"NCBIGene:5657","sources":[{"id":"urn:uuid:8ac06bb3-dc6c-4dd3-bcc1-250f50e8bfd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8626","original_object":"UniProtKB:P24158"}
{"id":"a04b209e-eea7-47ee-acfa-35d0fbf2a358","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230483","predicate":"biolink:affects","object":"NCBIGene:3276","sources":[{"id":"urn:uuid:46e6a477-d428-4f46-a675-6060da63a6a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8955","original_object":"UniProtKB:Q99873"}
{"id":"956972d1-1822-4534-b334-ae0b144646bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71601847","predicate":"biolink:affects","object":"NCBIGene:376497","sources":[{"id":"urn:uuid:01070453-be31-45d3-84f3-eb67a20b4bef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8801","original_object":"UniProtKB:Q6PCB7"}
{"id":"854ebf3b-f12d-4dba-b3e5-5181701d32ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177398","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:ed6152d8-480c-430c-bdcb-25c3264fab8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5605","original_object":"UniProtKB:P30542"}
{"id":"e3d6aaad-e4c4-47c3-a5c7-35de130bdb7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3654","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:7a12a94f-7a08-4100-b5d3-48de5effb1a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7147","original_object":"UniProtKB:P43166"}
{"id":"cf7e011d-2839-4e38-9ae6-0efe86dfc5ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4903","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:ee583725-3369-4177-b48d-e56d40f65703","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7071","original_object":"UniProtKB:Q7Z2H8"}
{"id":"75cca3da-7f18-4298-a489-ebea9b362a96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231208","predicate":"biolink:affects","object":"NCBIGene:19217","sources":[{"id":"urn:uuid:081d33e3-4352-49de-b5b3-3b588273ec63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1934","original_object":"UniProtKB:Q62053"}
{"id":"cee33f73-acb4-4391-a6c4-bc9f5d0d3064","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108303","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:3aaa1e5c-8bb2-4895-bdce-6042e3c66c87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3074","original_object":"UniProtKB:Q02769"}
{"id":"ea3b325b-0290-4b60-94cd-7563e95728e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137333453","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:a3a0dd38-2341-45a9-94f6-3c16d3314316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10230","original_object":"UniProtKB:Q9H1C0"}
{"id":"3256280e-1589-496a-b7ec-4b5a7efd5bf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4514","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:20170f0f-b726-483f-86f2-4b323e2ee4b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:355","original_object":"UniProtKB:P20309"}
{"id":"b48c0f75-72a9-4bdf-8fdf-663a2dd2f076","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:7525","sources":[{"id":"urn:uuid:c5e36dd9-d31a-42fc-9ec2-0ec8cb6bb478","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:P07947"}
{"id":"cd879348-d2e7-4cd9-b4b4-003e48f47ba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6456","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:570551cf-5e35-4b99-935c-be391d57cc52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2623","original_object":"UniProtKB:P04775"}
{"id":"98738b7b-7a39-4668-a03c-730bf0073846","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155187445","predicate":"biolink:affects","object":"NCBIGene:65018","sources":[{"id":"urn:uuid:94fa6619-6bff-46dd-9768-c042cf8f6494","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13011","original_object":"UniProtKB:Q9BXM7"}
{"id":"06d16796-783a-40ae-8ad3-970c9d4c8297","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2578","predicate":"biolink:affects","object":"NCBIGene:684516","sources":[{"id":"urn:uuid:72a7fd74-18dc-4577-a21e-15d633455394","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2578","original_object":"UniProtKB:Q63734"}
{"id":"e3c3aacc-7ea7-4cbb-ae18-8000f206974f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GA60WRR45J","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:af844267-b7e8-4fe5-a3e8-85c3802781d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1853","original_object":"UniProtKB:P25105"}
{"id":"046221ce-5bc8-470f-a64a-3360bf365071","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13299","predicate":"biolink:affects","object":"NCBIGene:10927","sources":[{"id":"urn:uuid:6ce467ec-1509-45e4-859f-66a93a629a05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13299","original_object":"UniProtKB:Q9Y657"}
{"id":"f26aaba3-0f3f-412f-9a96-60a069c44013","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:140973b7-ecff-4d8e-98c6-e906285a582b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q92769"}
{"id":"f0a8f9e3-1d4c-44a4-8d36-df8cc9f9c1be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2113","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:7cfd0fd3-710d-46b9-8e43-718a0f14b9f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2113","original_object":"UniProtKB:P29371"}
{"id":"8d3bcf05-86ed-4bc7-af0e-96a095a5dedc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91393","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:b2870e9f-9e1e-4122-b66e-b439571ce973","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9133","original_object":"UniProtKB:P35968"}
{"id":"21e75b7b-4cea-4aaa-88e0-14e1d6443fa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1C854K1MIJ","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:e19c9930-e882-4112-b02a-77950da817dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7888","original_object":"UniProtKB:P42338"}
{"id":"20799e92-3042-4091-84f1-550043fb75c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R318PGH5VP","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:c82c519f-9b0e-4d65-bbd0-f9a40ac507e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8500","original_object":"UniProtKB:P25025"}
{"id":"59a0f582-524f-4421-86ba-534fe2ddda3f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139035039","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:60b448c9-93b2-4d68-94c2-aed2f0c0e689","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11055","original_object":"UniProtKB:Q6IQ20"}
{"id":"b3fe0712-8fbc-49c3-9633-a6c304acf3e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993657","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:b2e5d713-ee70-4782-adcf-5ac8ed5dfdcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12572","original_object":"UniProtKB:O95977"}
{"id":"f5492f55-3461-430f-a0c6-5f0ee3153644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1815","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:9cd3f48a-38f4-49cf-9b36-0224829e90b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1815","original_object":"UniProtKB:P49190"}
{"id":"f2747828-3ea3-4449-88a9-8e49a7d15b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70175","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:79606b5b-bf48-444f-b501-b7d27fc49f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2498","original_object":"UniProtKB:Q8K424"}
{"id":"5082b2b5-db4b-403c-bedd-b9dae2053779","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68584","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:de2c7535-365a-4a9f-a3e5-47583e43a71b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2601","original_object":"UniProtKB:Q9NR82"}
{"id":"e373bfd0-002c-453a-8324-0e6ac12a98c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2222","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:3aa6466d-9e59-49d9-a031-5d05114c6c35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2222","original_object":"UniProtKB:P47901"}
{"id":"2dbf1ad7-b1aa-44d8-9f36-16feb7c1b11d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6102","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:bf8cf389-14d2-43c9-812b-5156db533eb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:650","original_object":"UniProtKB:P32299"}
{"id":"1cd0034b-cd45-4d3c-b63c-c6ad98a062bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167663","predicate":"biolink:affects","object":"NCBIGene:5045","sources":[{"id":"urn:uuid:052fb1eb-f68f-4aff-ba90-a34c6147c911","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8601","original_object":"UniProtKB:P09958"}
{"id":"a9fcaa8b-0832-4660-bf3e-3d705ce5b394","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73275","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:4f56b6d2-a89a-47c8-b80e-f813dc1df2f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7349","original_object":"UniProtKB:P03372"}
{"id":"9db6a5b4-aee5-4fa8-a645-1ffe0a19413b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138454777","predicate":"biolink:affects","object":"NCBIGene:201626","sources":[{"id":"urn:uuid:bf3ec60a-77b5-496d-8e9a-2cd11df46565","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12221","original_object":"UniProtKB:Q6L8Q7"}
{"id":"630563ff-a1af-4dfb-9d0a-766cb2d8d18a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993651","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:df49b95d-27b3-4541-b8ee-e7cf2c200d60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12535","original_object":"UniProtKB:Q9HCF6"}
{"id":"d5b48765-357f-411b-be73-6af46c141848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3889","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:fd9b5502-393b-4545-88c5-c107ab0a4da2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3889","original_object":"UniProtKB:P24053"}
{"id":"0de96d5e-1d85-4947-957b-0d6becd39b1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:a65ae0c2-4732-401c-be3a-45f0b7a3e84a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P29275"}
{"id":"3e357968-aff4-4b20-82a2-62246be94871","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63638","predicate":"biolink:affects","object":"NCBIGene:140679","sources":[{"id":"urn:uuid:66872536-d48a-4bdc-adf9-28dd5c8ad72c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4821","original_object":"UniProtKB:Q9H598"}
{"id":"f7cf6e4d-0e1a-490a-b5f1-b7ee514eaad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63925","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:128f790d-c60f-4d96-bd78-1738318f0c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1960","original_object":"UniProtKB:P43088"}
{"id":"0a507c65-3961-406a-855e-ef4269a8f767","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72312","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:625cd18f-f5d8-4763-ae72-3d165246b4d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2018","original_object":"UniProtKB:P30872"}
{"id":"a30b32ef-f194-466e-8bbf-7a959bd84b04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:0a18a14e-61d7-4f90-a4e4-486fd4e4759c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:Q02156"}
{"id":"a759d670-f77f-4b23-b382-31625a016f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2032","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:368173d5-460b-48c1-843d-36b7bf078017","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2032","original_object":"UniProtKB:P30935"}
{"id":"60497d9c-3ea7-4332-b660-32f6cb335fd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92519","predicate":"biolink:affects","object":"NCBIGene:10280","sources":[{"id":"urn:uuid:933c15bc-74a2-4375-b25c-15ff657471f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12125","original_object":"UniProtKB:Q99720"}
{"id":"9003bd8b-627c-4931-9a8b-e22bf1c68096","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:125348","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:49e5e68c-ad58-479f-9154-25c08fd385b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:458","original_object":"UniProtKB:P0DMS8"}
{"id":"856a8dfd-4fcc-44ed-ba65-8d37ee8255ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135613","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:ebca9876-c8f9-41f2-ad98-a8357749ceda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5596","original_object":"UniProtKB:P29275"}
{"id":"684cd70c-e2b4-44cf-97d5-d26106831622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8238285OA","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:2a2f32e4-a35b-479a-8afe-056ada79fd9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9307","original_object":"UniProtKB:P56718"}
{"id":"b9d6a8d7-6876-4ec3-9911-9053f122a345","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:64a8cb3c-fde7-4e12-94cb-3a7afe7ebab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:P35968"}
{"id":"68f116ae-ff95-4aeb-814b-4667180d67c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:91883d69-6286-4602-93d3-0bb36809489c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:O60285"}
{"id":"083c6043-f630-4745-9cad-a304518149ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6329","sources":[{"id":"urn:uuid:1e72657f-14d4-407b-85e0-90e81bbad472","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:P35499"}
{"id":"1c1c0d25-85d7-4ddd-9f3c-d435b8910af9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9990429","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:e7be0a6d-ab4e-41f0-b362-3e32164a1dd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1429","original_object":"UniProtKB:P31424"}
{"id":"5015fbbf-35c3-4c26-89df-e3b8fb0a6318","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:22068","sources":[{"id":"urn:uuid:2885b17f-7f84-4fb0-86b7-5346033f8d8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q61143"}
{"id":"214536b5-51bf-4e67-81e9-cca0b5791058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122211","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:5960eb67-2062-43b7-9db6-2157748b51fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:524","original_object":"UniProtKB:P18825"}
{"id":"6a8132e7-5c98-4e74-88c1-8a9ef455e8cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WYD79216A6","predicate":"biolink:affects","object":"NCBIGene:24784","sources":[{"id":"urn:uuid:2cf0d3df-3806-4f7b-b94a-ceb2eb4c7a95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8449","original_object":"UniProtKB:P26433"}
{"id":"fe1aab6c-90d0-43f5-8599-ffb84edabf4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2227","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:57594970-9e2f-4b02-9322-b078c71e07a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2227","original_object":"UniProtKB:P47901"}
{"id":"c6517902-1713-40ca-8c4c-c24b95eb371b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:8016395","predicate":"biolink:affects","object":"NCBIGene:57396","sources":[{"id":"urn:uuid:3f00ae4d-1cc4-49de-85fd-06a8b9ae0d28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12974","original_object":"UniProtKB:Q9HAZ1"}
{"id":"77e6987b-3bb6-4a0f-a01c-1a2afde6fc0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CW55R761RE","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:6366920e-af7d-4743-bc8a-1b29ef16fc16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:290","original_object":"UniProtKB:P08173"}
{"id":"ca5480bb-8a7e-4141-a543-d9cf80002e75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25015677","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:dba33ded-9a4b-4489-ae1a-757697f14191","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9403","original_object":"UniProtKB:P33981"}
{"id":"13f893a1-1f76-4f3a-9bf5-9aba94787749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827379","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:dc9cad61-5532-47e8-805f-cc262cbc07fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8600","original_object":"UniProtKB:P11229"}
{"id":"39d133ad-c0c3-4b95-a221-016cd32b524d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34849","predicate":"biolink:affects","object":"NCBIGene:24208","sources":[{"id":"urn:uuid:fd47d2ac-0a6e-4f42-a8de-f3f51cb676b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2859","original_object":"UniProtKB:P15207"}
{"id":"abcaa62b-dd2d-40d7-ace3-4765e4161196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118414536","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:0ac05bd3-0add-44a1-9e4a-53afb9d02414","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9666","original_object":"UniProtKB:Q9NWZ3"}
{"id":"bbe69c97-0abb-4e1a-8423-b838789a8f2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422755","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:4a07dc81-71b7-4e06-be70-388c790362ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13022","original_object":"UniProtKB:P0DTD1"}
{"id":"3c4a4b0d-459d-42ff-82fc-9d7d9f00704f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133818","predicate":"biolink:affects","object":"UniProtKB:P57059","sources":[{"id":"urn:uuid:6bf53743-165b-42e9-aa4a-05696ad40249","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8049","original_object":"UniProtKB:P57059"}
{"id":"99c637c7-32f8-4931-b2d0-1fa283965240","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:22Z53X5LHF","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:874838cb-5f34-4452-831a-ec19950dd010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10632","original_object":"UniProtKB:O60674"}
{"id":"3683feac-6d69-4330-8613-6b2e1b9ff31a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:38335241","predicate":"biolink:affects","object":"NCBIGene:5653","sources":[{"id":"urn:uuid:d2c87edc-a771-4ca7-bd0f-4995572b0062","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10575","original_object":"UniProtKB:Q92876"}
{"id":"956c7866-76fc-40f5-b5a0-8735d20826ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9065","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:63acb54c-4cb6-4b11-8351-413276313eaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9065","original_object":"UniProtKB:P41143"}
{"id":"3af6208f-e5ab-41cf-a424-bab64c6440d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16033","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:b8da8a86-2d7e-4863-8144-a6f4f5627eb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12607","original_object":"UniProtKB:P50391"}
{"id":"f808c35a-9014-4c0b-a6fa-81c81fc1e0c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1513","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:b2192acf-f5cb-4a49-9397-6926afb7236a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1513","original_object":"UniProtKB:P50391"}
{"id":"018288b9-957c-4c57-84e5-e5991df2335d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19DG7G1U5Q","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:0ee0866c-5183-4a46-8dbe-d0eaa1566e1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8917","original_object":"UniProtKB:P42336"}
{"id":"388ba849-427e-4736-9e6b-7fe56b673c5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2328","predicate":"biolink:affects","object":"NCBIGene:3742","sources":[{"id":"urn:uuid:3451abc3-ed16-405b-9ee1-cb14080b48c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2328","original_object":"UniProtKB:P17658"}
{"id":"b3fdcc3c-af73-4cbb-a837-8942d940921c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177765","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:e177ce96-50d9-44a8-8311-858fa1d85795","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8498","original_object":"UniProtKB:P25025"}
{"id":"69e4a0fc-9341-430c-85ee-4958788dd998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C88817F47Y","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:ff3ddcdd-7365-46fe-89cc-47c76eba0fec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8918","original_object":"UniProtKB:P42338"}
{"id":"ba7e23a1-11e1-4b5f-916b-ae2d3e068da0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177643","predicate":"biolink:affects","object":"NCBIGene:25652","sources":[{"id":"urn:uuid:ef0df5be-f594-4877-8bef-3927a6012ce7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1956","original_object":"UniProtKB:P43118"}
{"id":"c006e001-d3bf-444d-a6fe-6a4580583e1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:5a8a4401-1607-47c8-8939-41e8df8d9687","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:P49336"}
{"id":"1b534ce3-4a17-4fd7-bc21-4d4417b04cdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:114115","sources":[{"id":"urn:uuid:da965127-7b45-47ff-989a-01aa9b230cb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:P49653"}
{"id":"2141a8f5-f8c8-46f8-be7c-cba6f77f9e2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:73695a84-bc51-4aa3-b15e-515fad859ce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:317","original_object":"UniProtKB:P08482"}
{"id":"1ed4569f-483d-48cb-b12e-f12ec215873d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:d84aebb1-b01b-48da-8ee6-fb223b993a6f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:P50613"}
{"id":"3b691346-304d-4008-a31d-0a7538f2d680","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95066","predicate":"biolink:affects","object":"NCBIGene:10110","sources":[{"id":"urn:uuid:5663bf12-94b1-437b-a01b-f3cd6233abf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8040","original_object":"UniProtKB:Q9HBY8"}
{"id":"fb6b91b4-8f18-45dd-9beb-4b8559d39c5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5065","predicate":"biolink:affects","object":"NCBIGene:8795","sources":[{"id":"urn:uuid:cc866e31-fe4d-479d-bf45-a2d8fe5d84cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5065","original_object":"UniProtKB:O14763"}
{"id":"14dc2ed4-613c-43e7-91ab-d4e09763a737","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K9C42672RH","predicate":"biolink:affects","object":"NCBIGene:2268","sources":[{"id":"urn:uuid:133d8236-1486-425d-af33-97b5c8adaea2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8070","original_object":"UniProtKB:P09769"}
{"id":"5a524813-432c-46eb-b9fa-a75212e37d46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15899","predicate":"biolink:affects","object":"NCBIGene:10654","sources":[{"id":"urn:uuid:ca5d3d10-8904-487b-a60e-e10d3c7cb5a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3047","original_object":"UniProtKB:Q15126"}
{"id":"9db8bdbb-2c8f-4724-91ee-b2b8295ae3c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90724","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:c136739b-cd62-40a5-9772-0f4b6b78162d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3317","original_object":"UniProtKB:P20272"}
{"id":"5a349f71-b984-4e8a-b09a-790c76fe3596","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:61b07c7d-b6f7-426c-a39c-58fa70e25a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:P17948"}
{"id":"d3aea3ff-e7b7-4379-a654-1753e6e64b06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:4010455d-cd0d-4b1c-aed8-2ae8d7fc4397","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q9BY41"}
{"id":"0ad23c9d-28bf-4858-86a9-3f70203054af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4067175","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:d6310db1-1ffc-43ae-ba51-9dd7bc289185","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4067","original_object":"UniProtKB:A8MPY1"}
{"id":"512eb077-7054-4325-b3e6-0ae92088d152","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50990924","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:ec5fe361-36ff-42c6-8a31-38d8c1bb1775","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8805","original_object":"UniProtKB:Q8NEB9"}
{"id":"8b19cb4f-642f-4e2f-9d10-8bdc177ceae9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:a89e624d-9c5f-4a5b-b5a4-17b1f4a9958b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9HCX4"}
{"id":"40e7e55f-49f6-44bc-ba7a-d9fb3cedb748","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27584","predicate":"biolink:affects","object":"NCBIGene:25672","sources":[{"id":"urn:uuid:39ff55c4-031a-4ef8-9501-5b10faacf3ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3452","original_object":"UniProtKB:P22199"}
{"id":"ca4c0574-2170-4601-9d4c-20e9bf289500","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996538","predicate":"biolink:affects","object":"NCBIGene:80351","sources":[{"id":"urn:uuid:06c70b7c-2589-4a1a-b693-f83acb7c401d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10672","original_object":"UniProtKB:Q9H2K2"}
{"id":"84126cb1-f09a-497f-8c71-4f371658533d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49040","predicate":"biolink:affects","object":"NCBIGene:29881","sources":[{"id":"urn:uuid:6915318b-7165-47a9-a43f-0cb02b890cb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6816","original_object":"UniProtKB:Q9UHC9"}
{"id":"918ad420-b631-4c0a-b127-26c18cc9597d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81390","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:44a4f544-3233-48fa-9ad9-b2ca2bd563cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1251","original_object":"UniProtKB:Q9QYN8"}
{"id":"cea0bf70-3879-4528-b25a-80c5d9aaf66e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:16491","sources":[{"id":"urn:uuid:0c359d7f-3255-46d5-a4fa-eb3b0eccb570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P16390"}
{"id":"3a4328cc-9cf9-4887-9202-33feb2957619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1546","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:8ab30607-4b17-4e43-8cd5-e4db4131a5a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1546","original_object":"UniProtKB:Q63447"}
{"id":"a0b197f2-156e-4540-b126-3123ce7f5467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:8e15590f-762c-4626-9575-f608bc3b4fe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:P32304"}
{"id":"358e3a96-77ef-4c8f-9747-1f5c2fec9662","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E58MLH082P","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:92f40644-8d76-4dd1-b3ef-2bc6243cdc3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9042","original_object":"UniProtKB:P41180"}
{"id":"cf0fb2ff-2109-4eb3-8033-8519027af3de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:102","sources":[{"id":"urn:uuid:4121bdce-12d5-4864-b4e0-4bdd6320cc0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:O14672"}
{"id":"fb76554f-eb4a-4952-b93a-042c2b4dc1cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0896DN89BF","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:42d938f8-e4c4-4208-8833-a9f747ac6ca2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6427","original_object":"UniProtKB:P31424"}
{"id":"2a36bd5d-3730-4b4d-8b58-ef6f8e12d26f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2H6KVC5E76","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:af253ca8-3490-4df3-840c-dbba5078652e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4277","original_object":"UniProtKB:P31644"}
{"id":"70c4ab09-b3b4-4e23-857f-3718041743cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:8f5e9874-6c4b-4492-b876-c56a029941f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P30557"}
{"id":"b34e032d-42f8-4609-b7cd-774729f8623b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182183","predicate":"biolink:affects","object":"NCBIGene:121278","sources":[{"id":"urn:uuid:d4cca8f2-170f-4b82-8e97-2a11367b55ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5126","original_object":"UniProtKB:Q8IWU9"}
{"id":"5c94f86f-3659-42d6-841d-cf11dadf3dbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5898","predicate":"biolink:affects","object":"NCBIGene:65096","sources":[{"id":"urn:uuid:b6c63741-eb76-4135-9c54-23bd3827c782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5898","original_object":"UniProtKB:O88917"}
{"id":"fe570dc1-f797-4982-9955-09ee2a110d8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817484","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:18a7cef5-5700-41de-9287-ccdb4e4a04e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6117","original_object":"UniProtKB:O60755"}
{"id":"979cfaa6-a4e1-4df4-a323-bcb22daf0c06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:86c00e35-1321-449a-a3e1-410a48bbfb56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:P54282"}
{"id":"fb08bf3b-916b-4937-87f5-0f23efbcf368","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10894633","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:fc9c8036-880c-4133-ba7c-2486d7a88e99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1723","original_object":"UniProtKB:P47900"}
{"id":"a05d23c8-0e1a-4e1c-b2ed-b6e3cc55dd02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132374","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:65b7c81b-af10-43f4-8af6-d86fd99473be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2535","original_object":"UniProtKB:P54282"}
{"id":"746ac3b0-6205-4034-a0f7-5fbb225977a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:615","predicate":"biolink:affects","object":"NCBIGene:25264","sources":[{"id":"urn:uuid:af1c1c11-9fb1-44d2-b413-011bb72c3f93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:615","original_object":"UniProtKB:P24053"}
{"id":"ad85bc84-d7ff-4948-bece-8d003f56b599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:80c9b3bb-fe22-4bd5-8986-7f8c05047a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P21917"}
{"id":"e0d5b935-a4d4-44f0-be87-c8522593868b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1546","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:3e1f9218-ecb1-4bd4-bf8d-812962cfbf4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1546","original_object":"UniProtKB:Q61041"}
{"id":"412148ee-7d48-4d4f-b596-91e2197a19b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63976","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:64a01bb0-1891-4487-b606-43906af4c7e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1901","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"558a88b6-96ca-4f56-bcf5-7131fc29701d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91332","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:348bca27-a916-4725-9782-bbe192deb8b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9356","original_object":"UniProtKB:Q13464"}
{"id":"3e6f3791-90a5-4604-a00c-6adb1a4f7b63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:58972","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:f66a2f64-a16a-4cae-96f0-671be208e714","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6283","original_object":"UniProtKB:Q8BLA8"}
{"id":"aa1296e4-ef9b-44eb-a53e-b213589fcc1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3837","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:6cbd69f7-ca3e-4517-aa43-d55a888f1371","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3837","original_object":"UniProtKB:P24530"}
{"id":"b3533fe4-e2ce-40d4-8355-e5f9302bb4fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:127342","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:d6ee8d9b-9c68-4848-bfca-3c33929dbfb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7118","original_object":"UniProtKB:P23975"}
{"id":"7f68d754-a122-4278-a9d6-30215af04db8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114904","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:65d748ca-07ad-497f-81a7-4a14e96f5c78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2196","original_object":"UniProtKB:P37288"}
{"id":"f3f65331-bf4f-4480-98a9-e2fff2eeed22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53027","predicate":"biolink:affects","object":"NCBIGene:59264","sources":[{"id":"urn:uuid:352679ac-97f6-447c-9b7b-3362ca03b470","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3413","original_object":"UniProtKB:Q9R0Q2"}
{"id":"d7bd600e-b240-4b28-b502-707b2618b249","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1555","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:f636a454-2aac-4bbf-9be6-cdf3699f1dec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1555","original_object":"UniProtKB:Q63447"}
{"id":"dc4546dd-2bdd-46b9-a08b-3667ed900ee5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699447","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:6c361850-3693-4834-b322-3b1ed4add0cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11144","original_object":"UniProtKB:Q9NRA0"}
{"id":"3cbc647b-aa84-43e5-9f38-5af22d15bd99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:5585","sources":[{"id":"urn:uuid:2b6b5993-ee29-445e-ace5-d57d95884811","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:Q16512"}
{"id":"4bf6745b-f17a-494f-a834-2bd26683014f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6ZA31Y954Z","predicate":"biolink:affects","object":"NCBIGene:23765","sources":[{"id":"urn:uuid:806dc262-68d6-45c1-b059-5182de33e8ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7540","original_object":"UniProtKB:Q96F46"}
{"id":"8a2ec70f-9af3-47e1-8f7e-5caf952d1291","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7NL2E3F6K3","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:4320977d-f12c-4f67-8ba3-6ba22ad87120","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9744","original_object":"UniProtKB:P00742"}
{"id":"e8a2099d-a8e1-4bd5-83cf-7a3de58e126f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183901","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:69000a6b-bd40-4ff6-82e7-b8f536cd8131","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6196","original_object":"UniProtKB:Q9Y271"}
{"id":"6f47d40e-fdc7-4b64-be7e-088fd3b986fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16135415","predicate":"biolink:affects","object":"NCBIGene:774","sources":[{"id":"urn:uuid:0620105c-0946-46aa-b48a-485466761381","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2536","original_object":"UniProtKB:Q00975"}
{"id":"11fc84ba-c112-45aa-8600-540b9528f99c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:148293990","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:2d613f16-ca71-4ab6-8555-7155c57b62af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11950","original_object":"UniProtKB:Q07343"}
{"id":"e52a86c7-2e46-43f6-b1ef-bda4b5a6148d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168665407","predicate":"biolink:affects","object":"NCBIGene:5588","sources":[{"id":"urn:uuid:835aed44-41e6-4197-a038-da6ef5ec53e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13089","original_object":"UniProtKB:Q04759"}
{"id":"726fe6f1-ffed-4185-9bd3-1efc50f10b7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:f2f3ac42-87f1-410e-ad40-f136943cccd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P08253"}
{"id":"0970feaf-05c9-403b-9fb6-e687825bd266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53232451","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:50411e17-8765-489c-bbb0-2babaf37b7f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8123","original_object":"UniProtKB:P07949"}
{"id":"34059497-4b74-491d-a384-f810cc9a20b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50922","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:4796ac3c-580e-455e-9af1-95db0ea133f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:40","original_object":"UniProtKB:P28566"}
{"id":"d4129853-d979-4433-9718-6a22cefc3b4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12907","predicate":"biolink:affects","object":"NCBIGene:23166","sources":[{"id":"urn:uuid:e2b079e1-9e1b-4b9d-8c05-4c182dc8c8ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12907","original_object":"UniProtKB:Q9NY15"}
{"id":"d2716e0d-2287-45c9-bd44-7a356f3b4248","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21202952","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:996ee9ad-6cf8-4fbc-947d-feed2dd7243a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4208","original_object":"UniProtKB:Q13224"}
{"id":"30ff4db3-ccc9-48b0-9415-51ddf34765b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27960","predicate":"biolink:affects","object":"NCBIGene:4842","sources":[{"id":"urn:uuid:a8fed016-6b60-4b27-ba71-f3bff99ce7f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8759","original_object":"UniProtKB:P29475"}
{"id":"1c00fd37-4209-4fca-9054-7a7b86ddf751","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15996","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:d3c57034-3a29-4698-880b-255e7911bfa3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1742","original_object":"UniProtKB:P97794"}
{"id":"37565976-a4c4-4a7e-89a1-76a22ddf6378","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232381","predicate":"biolink:affects","object":"NCBIGene:9175","sources":[{"id":"urn:uuid:8954533a-5d0f-4c29-bcf7-393a90556422","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9355","original_object":"UniProtKB:O43283"}
{"id":"3821553d-733f-44bb-9844-1055544a0933","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KKV299446X","predicate":"biolink:affects","object":"NCBIGene:4311","sources":[{"id":"urn:uuid:873e199b-55f8-4ecd-8346-32b26b478b32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6506","original_object":"UniProtKB:P08473"}
{"id":"7b5827d0-e97f-4e7b-979c-18b7b7485e10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:84329","sources":[{"id":"urn:uuid:d12873e2-0164-4fae-bf99-f4b703f70f45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:Q96D96"}
{"id":"a0b75f9d-2251-4102-a57b-12436e37f060","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321155","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:2f6ed2c7-7241-4c17-a3e8-0fca81dd82a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10147","original_object":"UniProtKB:P23458"}
{"id":"d47dc924-1bd6-4138-b252-0996d566a27d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8405","predicate":"biolink:affects","object":"NCBIGene:10568","sources":[{"id":"urn:uuid:5405c871-e1dc-4524-ae3e-b0a9ea90f38f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8405","original_object":"UniProtKB:O95436"}
{"id":"930faff9-4649-4115-a3d5-54d14a67a7f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231400","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:f68cddc5-3983-4cc1-9545-41d10f3ae517","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9144","original_object":"UniProtKB:Q13822"}
{"id":"53de3128-5ece-433f-8daf-615478283bd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072556","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:84edd998-8bee-4240-9841-cf2865feebb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8999","original_object":"UniProtKB:P23219"}
{"id":"79556308-cb87-47b8-bc70-3746cd059483","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232556","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:bca966f7-fc6a-43b5-b67f-d7c26598384b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9039","original_object":"UniProtKB:P11362"}
{"id":"46c73f86-caa0-4c0f-a23d-8a9f602e5c0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61400","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:46550a9a-69fd-4ca4-b15b-ecc299f258e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9176","original_object":"UniProtKB:Q08881"}
{"id":"3d46d556-ae45-49d1-86ee-a88bc4957c55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C6RWP0N0L2","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:fd5cd888-3d74-40db-8538-589a7d3e714c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8126","original_object":"UniProtKB:P11309"}
{"id":"24bc6664-9812-4418-9be2-f4e435d13862","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611894","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:71d7af85-ad8f-4777-b132-8e2713623b02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9997","original_object":"UniProtKB:P42338"}
{"id":"58d39325-cc89-4151-b4f4-df779a78c989","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3176","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:0e8350d7-448b-4aa1-a417-428486da32a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6797","original_object":"UniProtKB:Q9ULX7"}
{"id":"718d6db5-a9c0-4393-8af9-663ac6df6045","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O1Q96UZ63W","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:019bb4f2-713d-41df-8958-8d270c337e9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3281","original_object":"UniProtKB:P0DMS8"}
{"id":"e4d148b7-5f5d-4454-b661-1b159d98d8f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166177189","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:2f0ce55f-bf8b-4260-a35e-ea1a4c2f0305","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12518","original_object":"UniProtKB:P27815"}
{"id":"b0c0dba5-6e36-427a-8af1-34e4a2dae611","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6519","predicate":"biolink:affects","object":"NCBIGene:242093","sources":[{"id":"urn:uuid:49fad081-4f78-4c89-bb8a-1506cb407792","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6519","original_object":"UniProtKB:Q7TQP4"}
{"id":"d5e01fc4-22d1-49f4-a602-05c1c1c9b20f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:26945","predicate":"biolink:affects","object":"NCBIGene:9975","sources":[{"id":"urn:uuid:100da2ec-d171-4f77-80fb-58a61c2357d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4349","original_object":"UniProtKB:Q14995"}
{"id":"122ac6f9-b952-4c3a-ab39-dabdb95b8085","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50815","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:3e4ef3cc-d38f-4798-86d2-b52edb24f88f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7091","original_object":"UniProtKB:Q9Y210"}
{"id":"0f316c55-4d8a-4da2-b18a-78e7d2e437c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5897","predicate":"biolink:affects","object":"NCBIGene:171447","sources":[{"id":"urn:uuid:fa1ce84a-87e7-4232-a3ef-b75605fa0a1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5897","original_object":"UniProtKB:O88923"}
{"id":"67b47269-3b04-49fc-bbe3-80a927c1db0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145371","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:75f09da0-66c8-49b0-8d88-6cc2b38bc4de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7921","original_object":"UniProtKB:P36507"}
{"id":"bf60d521-35b7-46ed-9ee1-0b2f1dbf9ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6139","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:62a01a8a-85d5-48ef-adba-9dc41f68c166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6139","original_object":"UniProtKB:O08726"}
{"id":"a4fd2bea-2145-4965-a87d-72062fd55fa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:c1d3f6b0-c835-471d-bea9-f8744e5a414d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P09619"}
{"id":"8b41db3b-262e-4fff-8934-962a27c27a44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13302","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:1ee89c61-9cd9-4b73-9cfb-15cc0e6b91e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13302","original_object":"UniProtKB:P36888"}
{"id":"937ec8c4-453f-45a7-af35-533feaf1f47f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:752","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:03073308-b76d-4924-8449-5f2dd1feacef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:752","original_object":"UniProtKB:P32246"}
{"id":"c6fda968-dd46-4804-a2ac-02d0c37436ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553174","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:8565388f-cb32-408c-9dac-7891b2b377f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10343","original_object":"UniProtKB:Q14164"}
{"id":"e8402ba0-2e85-4ff9-abe4-6ace4379a5f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813904","predicate":"biolink:affects","object":"NCBIGene:4353","sources":[{"id":"urn:uuid:8c71e441-d746-4bca-b288-6a8c57842cf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10051","original_object":"UniProtKB:P05164"}
{"id":"38676f2a-597f-4b63-bb69-ef6813cd28e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183901","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:b1379deb-2090-4dd2-82d6-a35988e428c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6196","original_object":"UniProtKB:Q9NS75"}
{"id":"908f0364-6aed-4b17-9445-733e3341e14c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10304110","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:958b8776-e9d0-4d27-a972-77409958b14e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:792","original_object":"UniProtKB:P51677"}
{"id":"0f3db05b-ddc7-4ae2-a873-281fbddf8b82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45951","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:c8cc3ed2-8f86-4d6e-be14-50fbc2567e16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:214","original_object":"UniProtKB:P28223"}
{"id":"80a00ca0-470a-4c46-ba38-b6942e9b139e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94559","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:c8ff44c4-e8c7-4bcc-8072-687ae8b9a46f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1214","original_object":"UniProtKB:P35367"}
{"id":"99e81683-ab76-4672-8966-cbfad5372262","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143117","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:1c6845db-9769-486d-8e83-86f8cf33f607","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7476","original_object":"UniProtKB:Q9UM73"}
{"id":"522ed84d-138c-4bf5-b27c-af9faa068eea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:44a3dbcd-b661-4f45-98e6-7777f65c1cdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:O43318"}
{"id":"b76f1e69-3450-47b7-9c5e-7172da74655c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T678746713","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:df780a40-0b5a-4892-9416-2c89ee473bd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9174","original_object":"UniProtKB:Q02763"}
{"id":"52a6417b-50d8-4498-bace-55d696bd4276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9654","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:47c099b1-e5eb-4042-aa84-d2853208638d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:213","original_object":"UniProtKB:P14842"}
{"id":"8ffa4261-3286-4a91-9365-a14f45d0cd87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:51035721","predicate":"biolink:affects","object":"NCBIGene:50507","sources":[{"id":"urn:uuid:f41a17fe-6cbf-4191-85b2-c7f7b1f20d4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9931","original_object":"UniProtKB:Q9NPH5"}
{"id":"6706607c-e5f7-434a-a2bf-c2997b85667b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y1HYC6SO3F","predicate":"biolink:affects","object":"NCBIGene:3676","sources":[{"id":"urn:uuid:287cea99-1392-4a67-a395-e063d205b745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10511","original_object":"UniProtKB:P13612"}
{"id":"0935decf-8c39-4e18-9b8b-88fa59fc41da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18050","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:08553aa0-e522-4155-b893-051af08972fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:723","original_object":"UniProtKB:Q5T6X5"}
{"id":"b3282104-c57d-488a-b7eb-50b1197b01fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:253342","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:eef2c77e-5b40-413c-9015-f5e0de53edba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2296","original_object":"UniProtKB:P46098"}
{"id":"67275089-47e4-4f81-9711-e7eb72f88067","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10313386","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:4935a772-0b8b-485c-b78a-b9a00bed1bd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:287","original_object":"UniProtKB:P11229"}
{"id":"5621d70e-a35e-4680-8891-2f55c208e882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139035063","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:f43d6a22-6801-49c5-a577-a02860a189f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10494","original_object":"UniProtKB:P35354"}
{"id":"9db60642-362c-4732-a947-9b284d597600","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1680","predicate":"biolink:affects","object":"NCBIGene:18389","sources":[{"id":"urn:uuid:35767b1e-000d-422b-9d5c-bb254fe911e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1680","original_object":"UniProtKB:P35377"}
{"id":"e51c2e8a-3572-4f57-8681-2fdcde140fad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10197","predicate":"biolink:affects","object":"NCBIGene:8325","sources":[{"id":"urn:uuid:9ad90753-b742-4fc4-828e-06e8a516cc49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10197","original_object":"UniProtKB:Q9H461"}
{"id":"571ced90-8e88-47b9-80fb-3d2ec3cc2c9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74766530","predicate":"biolink:affects","object":"NCBIGene:23235","sources":[{"id":"urn:uuid:b95c9ee3-1a54-4f6b-936a-2eb852342e02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9581","original_object":"UniProtKB:Q9H0K1"}
{"id":"81308a66-9c30-4d9a-8ba7-7035db3a214f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25147749","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:fa700e74-472d-496e-9de8-d7197d94e3e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2899","original_object":"UniProtKB:P61073"}
{"id":"b902cad9-8a98-43e9-a998-1e696f002e3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109549","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:c5e707e8-8861-4f52-9931-72c592b2c308","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1356","original_object":"UniProtKB:P48039"}
{"id":"75b0ac28-bd62-4665-a6cb-9fdea6dad651","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6523","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:ebbd108d-7d2a-4149-a93b-bf2522036675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6523","original_object":"UniProtKB:Q02644"}
{"id":"8adfa8c6-d36c-4316-93e9-28789cb489e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139512018","predicate":"biolink:affects","object":"NCBIGene:5781","sources":[{"id":"urn:uuid:320923f8-e6e7-4c56-9432-654dea3b426d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12970","original_object":"UniProtKB:Q06124"}
{"id":"221b41ac-5dbd-4723-a5da-c091770a4e61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:56666","sources":[{"id":"urn:uuid:4eccbee7-75ce-4438-8b74-e8be5ede0e1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q96RD6"}
{"id":"99ac280e-6fb4-4373-87da-c7ce53e0ae85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90647159","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:83c36399-87d0-45f7-8f39-e121b7e9a5f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11940","original_object":"UniProtKB:Q02750"}
{"id":"e77fe220-d302-4ca3-b937-9e42a9e3edfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13395","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:90905525-159d-4ba2-a17d-a29e6015256c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13395","original_object":"UniProtKB:P35372"}
{"id":"29cd8157-2129-4f3d-b11b-e22fc990cad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65408","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:2355071b-3668-4bb4-9439-08683880a5f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9675","original_object":"UniProtKB:P59540"}
{"id":"194c6884-af66-4090-abcd-ec8ab906e099","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41423","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:7ba26b8a-69ba-4e51-b41b-9f2f82bfbcc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2892","original_object":"UniProtKB:P35354"}
{"id":"bce3e97f-50a4-497c-926c-a8c86b8b0027","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M7X64VTLI","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:1745e8da-6b94-42f9-9f73-e05e125e7ca8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13204","original_object":"UniProtKB:P11309"}
{"id":"bebb0031-cd32-4199-8c0b-dfdc3729668f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40287","predicate":"biolink:affects","object":"NCBIGene:4842","sources":[{"id":"urn:uuid:6a59defb-7404-4c14-9003-bb259d174d57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5127","original_object":"UniProtKB:P29475"}
{"id":"778d5502-948a-47c9-8c0a-72d2d7225047","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9904703","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:1ac11e87-2172-4afe-a669-395d5d4cb30a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3363","original_object":"UniProtKB:P23385"}
{"id":"529b5c9f-5bcf-4f98-b106-daa53774d652","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34687","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:232549a6-5827-47c9-bee9-7b9685446c94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6295","original_object":"UniProtKB:O75762"}
{"id":"ed7b5c67-97a2-4faf-9f4d-d2bc6df464d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:151129","predicate":"biolink:affects","object":"NCBIGene:684516","sources":[{"id":"urn:uuid:d22d9910-d73f-445d-87b3-d303604364a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2577","original_object":"UniProtKB:Q63734"}
{"id":"cfd12205-9aef-4be8-9cc6-715f5e1c61b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8764","predicate":"biolink:affects","object":"NCBIGene:3615","sources":[{"id":"urn:uuid:a5e7724b-738b-4c8e-ae2b-4abf1d93ddc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6831","original_object":"UniProtKB:P12268"}
{"id":"7f5ef081-c69e-4000-b2b6-d6c812018de6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232354","predicate":"biolink:affects","object":"NCBIGene:171087","sources":[{"id":"urn:uuid:219892cd-d85d-4bb9-b9cd-26764b2b0b46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11302","original_object":"UniProtKB:P63031"}
{"id":"3cc6e46c-820a-4218-9835-145f46b6c457","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9674","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:ec360457-5c25-43b6-9e40-83b25295c979","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7313","original_object":"UniProtKB:P31644"}
{"id":"b1bfb01d-69d5-4547-982b-f8a1786405e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:624746","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:30fb492d-6e80-4136-9de7-b335e571800a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1565","original_object":"UniProtKB:Q15761"}
{"id":"151aab71-a9da-4604-a5ac-b42141902ef1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6427","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:252b6ebf-161a-4d7a-8a45-95312d266b34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1175","original_object":"UniProtKB:P30969"}
{"id":"5b5c2981-e9c2-42b5-bf1a-4431acdf5536","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15118529","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:f91bcd6a-3677-43ae-bc97-ce243f5ab34a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:340","original_object":"UniProtKB:P08173"}
{"id":"3ad74fb2-a9cc-4be9-ae20-31f923c330ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:771","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:7cbf8fec-0ae2-4fb8-b85b-7ab02f2851a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:771","original_object":"UniProtKB:P41597"}
{"id":"55c57ad3-b30e-4bfb-944d-ae6878911561","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90217","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:29eb9cf0-2dc3-4d8e-ac74-b764dbd6c784","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5658","original_object":"UniProtKB:P09619"}
{"id":"202e7fea-a5c9-445e-9a0c-6831ad98e81e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66665322","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:49b73df7-b8e7-4048-bd7f-52de783a2a35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9822","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"e8c0ad67-6c94-45ec-a559-9a80cd827e30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:216241","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:5160d4e4-75b2-48fc-b091-3930ad627d81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2654","original_object":"UniProtKB:P13631"}
{"id":"eea190dc-351f-474f-8e2d-21012eb6c10c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:931","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:a62028ff-868d-45ac-9239-919b0563b6f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:931","original_object":"UniProtKB:Q13324"}
{"id":"07fec47b-b513-44ac-8584-90f211a9720d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:486830","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:16b42f90-380f-4295-8c1a-c18a4db0772a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:768","original_object":"UniProtKB:P41597"}
{"id":"14aecc26-a488-4f3a-b1fd-c215790ca3ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132337","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:db66a170-2958-4c59-858d-40904eb08d22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:238","original_object":"UniProtKB:P97288"}
{"id":"6446fda8-0d7a-4cd7-816b-3f82e3460711","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:10298","sources":[{"id":"urn:uuid:4c62df4f-7c31-4262-81d6-afef3fbf4542","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:O96013"}
{"id":"445c324e-e0d8-4fa8-ac36-f4f596c8cd6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:153610906","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:377d210a-ea3a-4543-97f9-3f70c3899ad8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12484","original_object":"UniProtKB:P45984"}
{"id":"3639e248-6114-4e08-a71e-28987b440c5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44547183","predicate":"biolink:affects","object":"NCBIGene:1592","sources":[{"id":"urn:uuid:f0b894ad-c923-4a2d-92ed-1b19f94a3c4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8790","original_object":"UniProtKB:O43174"}
{"id":"50ce086d-33fe-4ab1-9404-79541e32c74a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:0c205de7-e0f9-4618-b0bf-a2731352c6ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P30680"}
{"id":"9e65c856-619c-49d1-a5c7-a42aa4c4c999","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813912","predicate":"biolink:affects","object":"NCBIGene:240","sources":[{"id":"urn:uuid:c0c8ca59-979a-48c8-84c4-123b7d24bf33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10079","original_object":"UniProtKB:P09917"}
{"id":"807a3439-8d63-4217-acbb-60b750634991","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4545574","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:718e97dd-176d-44de-adce-bc39af680c6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1406","original_object":"UniProtKB:O15303"}
{"id":"9bb7f306-39ce-4250-b6c1-14eef5ab0b6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168842984","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:0af2af52-8d79-4adb-bb91-864923dc2a4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13940","original_object":"UniProtKB:P08581"}
{"id":"8c23e8c8-22d8-4211-ab1a-6ce9fe15479b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:160283094","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:a8041d43-5867-4b53-ba94-f4e32a4596a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12387","original_object":"UniProtKB:P00533"}
{"id":"8c7482f2-f184-4273-a4cd-6c0c51019134","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6427057","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:93aad405-a3ef-4fad-97fc-b38ca18fce59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2373","original_object":"UniProtKB:P36544"}
{"id":"f7f1309a-31e6-4955-bfbe-58f19fb826fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:c28224ec-c0b2-40f6-b0e0-d975f8252603","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P08172"}
{"id":"36404a9e-a8d1-4ffa-aaf8-11c15b9363d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53378752","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:b8989175-bf5d-4852-8a6a-c55277711760","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10283","original_object":"UniProtKB:Q9HCX4"}
{"id":"f1d89082-58d7-42f5-bc71-69754badf89c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9796408","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:bb456762-164f-4e0c-a56e-b1ea86f06a47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:170","original_object":"UniProtKB:P28335"}
{"id":"70519d80-1d54-4495-8b6c-b83edd3aea16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:23a0b045-e9a7-49c8-89e7-6e124bbf547b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:P31421"}
{"id":"42a61a56-3e7d-43a0-8a44-30835f374478","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311382","predicate":"biolink:affects","object":"NCBIGene:7465","sources":[{"id":"urn:uuid:e0b99189-6514-48d6-81d7-4ed3487c2f44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8183","original_object":"UniProtKB:P30291"}
{"id":"494f6e3e-3d94-4cb1-a570-fdb1e71c39c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:67119","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:ea9a3be5-182f-4c36-b2da-baa62ae898ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1782","original_object":"UniProtKB:Q13304"}
{"id":"35bde0f6-7d7b-4231-b1cf-c549ff107b63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1172084","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:980cd4b2-479e-4235-a9d1-2d5bf45c93a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5564","original_object":"UniProtKB:Q9Y2T6"}
{"id":"dae555a2-0f4b-426d-878e-558dc56baee6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71466","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:2de1edde-244a-4c80-bdbe-74758c86cb7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2661","original_object":"UniProtKB:Q9Y2T6"}
{"id":"4df25719-49ea-4b16-95b8-699e599fca1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:2c69df95-c8c0-4199-b5d2-9ddaee66dcbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P07550"}
{"id":"b2407b13-b7ab-4abf-bdf4-84ca36323f55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61399","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:aa4e51a7-3292-47ac-9faa-baccdfa46197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5675","original_object":"UniProtKB:P00533"}
{"id":"cdb60db2-b80b-493d-97ba-4d4d7f1e6fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3970","predicate":"biolink:affects","object":"NCBIGene:8973","sources":[{"id":"urn:uuid:4c87db01-23a2-4618-83d0-54e4e6627ead","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3970","original_object":"UniProtKB:Q15825"}
{"id":"61060379-85db-444d-937f-881cc346ca3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9891167","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:1d029e35-b441-4b39-8243-8ce19e140690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:491","original_object":"UniProtKB:P35348"}
{"id":"f5734b62-bf50-47b4-b0b4-b1e4a3e302ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:cdd66793-d24b-4d6c-be78-45b533caf5ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:P36888"}
{"id":"cf97ecc8-0b13-4b9a-b92f-96585f34d341","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:89994f32-d3d0-489f-88c3-6df3482de1b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P08172"}
{"id":"38cc680b-faeb-4744-9145-dcf708633a85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91666633","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:5c049dfd-09e0-43c3-9a77-07c6b95941af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10003","original_object":"UniProtKB:Q9UQD0"}
{"id":"b4837772-2e1b-456f-9593-55831f10f00f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PV6YEC8983","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:8abf98f0-e845-48f7-81ec-0774205a1d6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4166","original_object":"UniProtKB:P42262"}
{"id":"20d9ec3b-19be-47c7-bff4-54fe9e9c52f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122670075","predicate":"biolink:affects","object":"NCBIGene:4056","sources":[{"id":"urn:uuid:d6a2b5b0-3e87-4a8e-b24e-b037e211637c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9555","original_object":"UniProtKB:Q16873"}
{"id":"89fb8f5a-0e18-41b9-a619-d93e60632192","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5134","predicate":"biolink:affects","object":"NCBIGene:5241","sources":[{"id":"urn:uuid:08a5e8d0-f12d-4c2b-ae98-c7029b5f7193","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7080","original_object":"UniProtKB:P06401"}
{"id":"0c9c2e66-44c9-4810-9afb-c6cf8274b23b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129887154","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:b9b02765-6f2d-4a8f-bffb-a25d28964220","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2269","original_object":"UniProtKB:P41586"}
{"id":"55e81a69-a026-4744-bb92-08958a6b8c86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129165016","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:ee1a2548-a35c-41d9-8c67-bd38bca042bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12350","original_object":"UniProtKB:P52333"}
{"id":"6f806513-bd00-4c72-b08f-ad53c09bfc7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95071","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:0403302c-72e1-4b3e-9f56-58d64d50c823","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8365","original_object":"UniProtKB:Q969S8"}
{"id":"f01d40ab-1cf0-45d4-96dc-f541cff02193","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VQ1AN3OO42","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:78463349-bca0-45e3-8f03-fe29afc19bd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13223","original_object":"UniProtKB:P0C6U8"}
{"id":"2e185877-0f9b-4481-a420-5fe75b8dcef2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138674003","predicate":"biolink:affects","object":"NCBIGene:619580","sources":[{"id":"urn:uuid:b484bebe-2d9b-47e8-a0a3-c6045a9438e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12314","original_object":"UniProtKB:Q5U2N0"}
{"id":"16ae7278-50ee-4437-a634-82a81215c6c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6L5D03D975","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:d5f03e3f-38bd-418c-bf35-34e41a123e00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9914","original_object":"UniProtKB:P10721"}
{"id":"e14429af-db08-47b8-95f6-fa8ee5548aa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3842","predicate":"biolink:affects","object":"NCBIGene:29555","sources":[{"id":"urn:uuid:c897ecc3-320e-483c-8a93-e518196a0c27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3842","original_object":"UniProtKB:P35000"}
{"id":"b8af5289-45e2-498e-b2ed-349d03575bdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10660","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:f1d73714-2154-425d-8062-3ccbb0feed32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10660","original_object":"UniProtKB:P30988"}
{"id":"993e075a-1421-431b-aca7-345f0d369860","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FI3KTC550","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:97c89993-7265-47c0-8560-6b2e4577a29d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4327","original_object":"UniProtKB:P47869"}
{"id":"67c63a79-ae40-4a07-baee-d7451b8909a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145431","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:30ede517-b1dc-4125-b420-60baccc74773","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7046","original_object":"UniProtKB:P43166"}
{"id":"d4762ef6-60b3-4165-900c-ec51f05d0962","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:c569115c-8212-4e86-b245-2de3007d8d44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P18825"}
{"id":"7d9e122a-ce8f-44f3-abbf-1501ca1a5051","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5PC250KSSH","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:1b2c49bd-92fa-4423-b7cb-7afb3e863ae2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1737","original_object":"UniProtKB:P51582"}
{"id":"8d5b3cb1-17d5-4f8d-a5aa-578923829fde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6438","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:e0db1d1b-d030-4f2e-b732-83a6ee70de75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:570","original_object":"UniProtKB:P13945"}
{"id":"da691a89-fee9-4d75-aaab-483fed8f1e39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:96e77872-8c33-4306-8d53-60717fb3f3a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1399","original_object":"UniProtKB:P31422"}
{"id":"c843f8a1-ebbd-4a02-b8d0-b36e5e228912","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4358","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:dd52d42a-d9e0-4895-a386-4370f83e60f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4358","original_object":"UniProtKB:P49682"}
{"id":"dd59d76d-0a7a-42b2-8103-c432e7dfe453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1649","predicate":"biolink:affects","object":"NCBIGene:4842","sources":[{"id":"urn:uuid:4d8d81a1-9efd-423c-9b20-c46451039305","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5113","original_object":"UniProtKB:P29475"}
{"id":"5a7ae29d-00f6-48c5-8125-1f142e8b8122","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57999583","predicate":"biolink:affects","object":"NCBIGene:3707","sources":[{"id":"urn:uuid:2f5c0bf3-5687-455e-b6e8-86cb6c2e6d1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9548","original_object":"UniProtKB:P27987"}
{"id":"2b9c58d7-71b6-46ae-8f9b-468faa5c8cc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:adffb169-6507-4378-8efb-eb8b7002e8c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:O95180"}
{"id":"9800836a-cc5d-4208-b0e4-11417789138d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YTL7A418KQ","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:fd56ee25-8a6f-4218-b795-a8056dbcc58d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8391","original_object":"UniProtKB:Q13547"}
{"id":"5fd5af5f-3999-4768-ae90-9b67d254b20a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:149226","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:ae3b2c3c-5573-43a1-a7bf-bf7b3b7480de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:557","original_object":"UniProtKB:P07550"}
{"id":"ba958ed0-ae55-4bb4-b57c-2481483d139a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:445501","predicate":"biolink:affects","object":"NCBIGene:23770","sources":[{"id":"urn:uuid:e8d13968-9416-45eb-b2b9-8fe2e782ea78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11483","original_object":"UniProtKB:Q14318"}
{"id":"052301c1-3ae9-4e98-95f3-db5ce1344924","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95077","predicate":"biolink:affects","object":"NCBIGene:7403","sources":[{"id":"urn:uuid:b9bbcc55-65ef-4ffd-b3b6-cf1b766a444a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8979","original_object":"UniProtKB:O15550"}
{"id":"a1fc2e60-c92b-4d78-9543-85cc7980a60c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92732","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:d105af49-0979-4a43-9298-828a5f9006f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8245","original_object":"UniProtKB:P17948"}
{"id":"100231ad-7026-4776-bd38-da818475e54c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90524","predicate":"biolink:affects","object":"NCBIGene:5287","sources":[{"id":"urn:uuid:88a0aa13-a1ce-49c9-af3b-20a37214592f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5701","original_object":"UniProtKB:O00750"}
{"id":"f096376d-bf42-43f4-83b0-f38bcba4c7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70707","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:762c1f9a-b4a1-4782-9461-3c478f83e690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7427","original_object":"UniProtKB:P35462"}
{"id":"c74cd819-e8b4-4c4e-8cc1-07686783ea1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:98Y1I8ZD4M","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:e2885e10-a3ea-4bd7-8892-cd8f23cfb7e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4082","original_object":"UniProtKB:Q13224"}
{"id":"2e11271e-a5fc-42bd-b708-a8b2e8e76f80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:57144","sources":[{"id":"urn:uuid:68b604a8-cb43-4fbb-915b-a4f05e978ff0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q9P286"}
{"id":"c906a1f6-b6c6-4682-b15b-2396280ad5f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:a514392a-5a30-45e3-8450-2250c5e53ee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P35462"}
{"id":"39b69f56-5788-41f3-bafd-2c8390dfca83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7851","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:ce300fb8-21dd-46c0-9b98-3fd4dda2dc15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:302","original_object":"UniProtKB:P08482"}
{"id":"1f98748f-31fd-4443-b914-febd29bdac3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25227533","predicate":"biolink:affects","object":"NCBIGene:497009","sources":[{"id":"urn:uuid:c8f1f538-2e08-4c1e-8ab9-11f3ad6f8dd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6493","original_object":"UniProtKB:Q5KTC7"}
{"id":"a17d9291-66e5-41af-93b6-52b4d2662ac5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:768FW21J3L","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:8ab161ca-ba46-4f19-880c-f12222f2b655","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7886","original_object":"UniProtKB:P35968"}
{"id":"599e9af3-c75d-4c1e-a8b1-a7d7a5b27813","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156525534","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:57341434-8668-4daa-b146-0f5b7f042029","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13336","original_object":"UniProtKB:Q9UBN7"}
{"id":"443f66eb-55af-4c11-997e-97e84a0780dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42596951","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:4184f4e3-1fbe-4dd5-b15d-5ab2be5da30d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4040","original_object":"UniProtKB:P35408"}
{"id":"3d12ab52-4ba7-4239-abed-0385013f85a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:55285412","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:9a436ff7-ed80-4e1e-8e26-8c4679770e32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4143","original_object":"UniProtKB:P28476"}
{"id":"795a5f85-8cbb-4833-97a4-15b900045643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2235","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:aa619cfc-addc-4b10-a7c0-9cbd5c4f44a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2235","original_object":"UniProtKB:P30518"}
{"id":"2a38046a-8c11-486d-8557-a69626f4e46f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U3T5W003VP","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:507dcbe1-8529-4a37-a1b3-22fbf82df37d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11730","original_object":"UniProtKB:P06239"}
{"id":"17c8ed7a-ee68-40ef-abbd-d90576ba42e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:64ONO62P28","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:b7877edd-03ee-4f7a-a748-5952df4c5426","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9303","original_object":"UniProtKB:O43614"}
{"id":"a15f7aa8-c5fa-4c0a-9a7d-ebc0c9975a9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93175","predicate":"biolink:affects","object":"NCBIGene:6916","sources":[{"id":"urn:uuid:f1880539-0f58-4a2d-a67a-ed5c3ac56a9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11379","original_object":"UniProtKB:P24557"}
{"id":"75556a8a-dbaa-4eb0-b621-a1e30aa5ab96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2214","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:269b2b42-dcb4-4d5e-80b3-ce7d7e38eb33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2214","original_object":"UniProtKB:P37288"}
{"id":"a20c65d8-752b-4c4b-8263-f952389e9acd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233593","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:391a501b-d96e-4146-b2e3-62eee2fddad0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9913","original_object":"UniProtKB:P10721"}
{"id":"0615d4da-f348-47e0-9856-7ce7a3844149","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:4b2df3fb-c67f-4051-a522-2ab1ff1ef2cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:P30874"}
{"id":"6e093d1d-6c98-4636-a75d-e87041f160e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61058","predicate":"biolink:affects","object":"NCBIGene:1644","sources":[{"id":"urn:uuid:b22c7518-25cd-46eb-a7a0-26cd6853e5e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5217","original_object":"UniProtKB:P20711"}
{"id":"5f59d89d-a391-426d-9c95-3216ef095d0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16122556","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:d91e763c-9f07-4ed3-a673-8fca0a469b07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7978","original_object":"UniProtKB:O95749"}
{"id":"7e7bcccb-e7ca-40e2-8b7e-9f2ba049a3d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312463","predicate":"biolink:affects","object":"NCBIGene:27005","sources":[{"id":"urn:uuid:00cf874a-a6e5-4a84-8d24-5b27695f91ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12479","original_object":"UniProtKB:Q9UK80"}
{"id":"7fc0d5e4-5ca5-4853-9c06-6e76c0dd5388","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:e24c17e4-3d06-4f06-a24b-3def5c09b83b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P19020"}
{"id":"38d70b40-4cca-4a3f-9c0b-dc74661a039d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167495591","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:8cc5ab29-604a-494b-b9e3-9e1e82134dea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13845","original_object":"UniProtKB:P00742"}
{"id":"978dca51-7022-4553-844e-fa150d78b064","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135957","predicate":"biolink:affects","object":"NCBIGene:5478","sources":[{"id":"urn:uuid:9f1b6784-9b81-4874-9866-9d097847f6c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11388","original_object":"UniProtKB:P62937"}
{"id":"a3ec2e9c-55ae-4042-a989-77b2a8d88f00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:596810","predicate":"biolink:affects","object":"NCBIGene:22368","sources":[{"id":"urn:uuid:442414da-fab4-4333-94b8-8d037cdb8f64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2494","original_object":"UniProtKB:Q9WTR1"}
{"id":"03564f9f-10ee-49df-bd18-3878c0218f76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9885936","predicate":"biolink:affects","object":"NCBIGene:132","sources":[{"id":"urn:uuid:72eeeae4-9da0-4abf-97fe-1297a8603f73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5130","original_object":"UniProtKB:P55263"}
{"id":"49a60a5b-489c-4e66-8cd9-6a30b8483d37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10356116","predicate":"biolink:affects","object":"NCBIGene:1188","sources":[{"id":"urn:uuid:98655831-ab10-45b2-9a7d-570e149a0211","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4104","original_object":"UniProtKB:P51801"}
{"id":"136eaf24-31cb-4728-bc8e-05eb6bff3d9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11491","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:7eac9cf9-3ff6-4b9d-ae77-6d4dcdff7c57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11491","original_object":"UniProtKB:Q9GZQ4"}
{"id":"af704cb3-0a73-4b65-b6ef-e11818f2c21e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91628","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:6825fe3e-1949-4702-9677-d8784862cb66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:541","original_object":"UniProtKB:P13945"}
{"id":"a0505566-d79d-4034-ac04-ed3d78cc47fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O937X0Z5EM","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:d74da28b-055f-4af9-a8b6-b582df582d25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2689","original_object":"UniProtKB:P37231"}
{"id":"48411358-91d6-45fe-8f0f-1f3d09c521be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93752","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:df28ca2d-7fbd-447b-97cb-41ed35b29b12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7955","original_object":"UniProtKB:P42336"}
{"id":"1efc7bd3-310e-4e81-a8d7-c7535c8a59fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80229","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:2cee9b53-4cfe-423e-b760-d61c93281580","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:616","original_object":"UniProtKB:P30550"}
{"id":"814f6589-4150-4509-a4f4-079c87692e49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3086547","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:41d640ce-ef51-4bea-8416-2c646eaeea45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:244","original_object":"UniProtKB:P97288"}
{"id":"740b67c4-e5ef-4783-871c-1984a87bbec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50169","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:2e8f89ed-15e4-48a5-9094-ed08e75735b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4108","original_object":"UniProtKB:P31644"}
{"id":"8bd797e2-d844-4c50-96b6-e850a86037bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10486131","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:71437acb-f5df-4a0f-b8d9-dd586f067d05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1621","original_object":"UniProtKB:P33534"}
{"id":"a9f461cf-c5d7-4ab6-a26e-54bf62436f11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45485268","predicate":"biolink:affects","object":"NCBIGene:1889","sources":[{"id":"urn:uuid:48d340eb-ded9-44ef-9397-bf015ad8cf30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6562","original_object":"UniProtKB:P42892"}
{"id":"dfb9d1a9-78a9-43db-9582-f3e1f4b29f27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130431484","predicate":"biolink:affects","object":"NCBIGene:100911581","sources":[{"id":"urn:uuid:5f0a4891-9479-4417-a190-c74c016964cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10124","original_object":"UniProtKB:P97612"}
{"id":"bb3decd8-c751-4173-ad44-662ff16ed5a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133809","predicate":"biolink:affects","object":"NCBIGene:2677","sources":[{"id":"urn:uuid:cd24023e-8ee2-44aa-a718-4060bc305d4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6960","original_object":"UniProtKB:P38435"}
{"id":"7d17000e-6259-4508-a799-dad47535d898","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13420","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:ef34502c-5c81-4da0-90cd-be0453109646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13420","original_object":"UniProtKB:Q06187"}
{"id":"1e738e3f-956f-430d-9960-2de2adc67447","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25183622","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:cadd0386-91c2-4809-b696-38c1a760b675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9014","original_object":"UniProtKB:P45452"}
{"id":"2dc38424-9a80-4de9-a85f-369e0e6ee109","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44446672","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:5c3d221e-fe6c-4abb-a9e1-77fb4860d7fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3011","original_object":"UniProtKB:P51639"}
{"id":"fa425e0b-6d54-481e-9ac7-45a144d2e8e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1005","predicate":"biolink:affects","object":"NCBIGene:1910","sources":[{"id":"urn:uuid:74fc93b9-9e1d-437d-bf16-b377dffa6013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1005","original_object":"UniProtKB:P24530"}
{"id":"57fe988d-d1f8-46a2-a44c-4834f4ed85a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91351","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:627fd970-2033-416a-8fbd-0df9ebf797ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8204","original_object":"UniProtKB:P31751"}
{"id":"e353c559-ed48-493d-adb6-3de84f24562f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2709","sources":[{"id":"urn:uuid:8dac8017-369e-4e4a-b41d-1eed4d70c3d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:O95377"}
{"id":"7dc1db3e-880a-41d2-b8d5-116222beafe9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177647","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:8e555e62-dde0-4c6b-b77f-1ddb90c20734","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5604","original_object":"UniProtKB:P0DMS8"}
{"id":"b72177a1-c98d-43fa-be57-eebeac517698","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6717","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:c8865f25-732a-4c99-b7bd-8e5b4b4e4df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2593","original_object":"UniProtKB:P35354"}
{"id":"0d220f14-3013-4ef2-a317-3d4a3bdeea99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4854412","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:9ba21455-2a01-436d-bca3-cbed979414eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11837","original_object":"UniProtKB:P35414"}
{"id":"2a346ec8-7949-4af1-875a-51389abbe44a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755180","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:f7d2799b-7b91-4770-9969-af9a06a77990","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6176","original_object":"UniProtKB:P28336"}
{"id":"1d351e48-3a32-4210-b4e1-6bb3a34b01e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:353174","sources":[{"id":"urn:uuid:51250ff6-9b52-47fd-855b-824315dc6d3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:Q401N2"}
{"id":"1004cae1-c310-453d-b00b-8e17b8650619","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44240744","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:41ad3a2e-ed14-4857-bb83-35bd4eadd23b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3966","original_object":"UniProtKB:P36544"}
{"id":"d812e449-4e82-4cd3-926b-72a884fc0a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5834","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:0a788a1e-25c8-4e31-92d1-32aec06ab627","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2764","original_object":"UniProtKB:Q9Y210"}
{"id":"66da6c16-7453-46fe-a8eb-19dd6f264b68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:916","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:ea272529-e4ef-45e0-8bcb-e73aae4a2439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:916","original_object":"UniProtKB:Q13324"}
{"id":"a6783ad4-6e63-43a1-8edb-e40989b042c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8925","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:aeb57af1-2773-453c-93f4-b9be0a7316f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4303","original_object":"UniProtKB:P21817"}
{"id":"65a05d0f-7c90-4483-830c-99b1ddf8039d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DRZ23E4F7","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:71a55a2f-d143-4c7e-932e-b700b2501da4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5619","original_object":"UniProtKB:Q60614"}
{"id":"751ad3de-6bad-4576-b6fb-8b080ef12fe6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13527","predicate":"biolink:affects","object":"NCBIGene:5795","sources":[{"id":"urn:uuid:ed9e1b37-4e92-4f14-aaaa-63ad6e9ade26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13527","original_object":"UniProtKB:Q12913"}
{"id":"cedcdbc7-13a4-4920-a188-60ceb602ecde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4415","predicate":"biolink:affects","object":"NCBIGene:12776","sources":[{"id":"urn:uuid:225b3c8f-f3bb-4949-a4bd-fc2485c0f28c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4415","original_object":"UniProtKB:P56484"}
{"id":"78337cc9-6542-428b-843b-cb2375603702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95129","predicate":"biolink:affects","object":"NCBIGene:25324","sources":[{"id":"urn:uuid:620c9185-11c3-4a02-ab04-c71472231650","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:240","original_object":"UniProtKB:Q62758"}
{"id":"ef3d0d42-e553-4ba5-9efe-b790e7fee85b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4466","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:9e1d295a-c01d-44c8-b353-a49c25555512","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:521","original_object":"UniProtKB:P18825"}
{"id":"8d302fed-6288-4568-9098-d1ddd40c3c64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155128494","predicate":"biolink:affects","object":"NCBIGene:8726","sources":[{"id":"urn:uuid:a8e0e553-7480-41c5-8db7-7f485ebbd448","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11523","original_object":"UniProtKB:O75530"}
{"id":"be586033-b5ed-4d6a-bbef-3c84f5001150","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:228259","predicate":"biolink:affects","object":"NCBIGene:56950","sources":[{"id":"urn:uuid:646296a3-7c43-4258-9c0b-28e5f472370d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7021","original_object":"UniProtKB:Q9NRG4"}
{"id":"319ae3c6-0a67-47cb-8903-fd1a974f5e7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4853","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:5d7b3392-b556-4573-b9f9-82fc3b765192","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4853","original_object":"UniProtKB:P20594"}
{"id":"65f34eda-a2f5-48e8-8fa9-698d1390a523","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3DSH8LL4L","predicate":"biolink:affects","object":"NCBIGene:54814","sources":[{"id":"urn:uuid:3aa594a4-a5d8-4a0e-a759-4e184b665260","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13397","original_object":"UniProtKB:Q9NXS2"}
{"id":"839480d1-7605-4b53-a845-a6f9f71629cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93765","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:059d1856-fad5-43c8-8565-6f4e7bf0ad14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5969","original_object":"UniProtKB:P11802"}
{"id":"2d29bca1-b339-48d5-8bc0-5211b6fb4c0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44386062","predicate":"biolink:affects","object":"NCBIGene:25555","sources":[{"id":"urn:uuid:4acc8cf9-6145-4b51-894a-f136a4385842","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2019","original_object":"UniProtKB:P30937"}
{"id":"9ef5fbf1-b7ad-44b1-bb15-e14ff213f3c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77733","predicate":"biolink:affects","object":"NCBIGene:246153","sources":[{"id":"urn:uuid:56c6485c-6252-486b-bca7-dc4811cbb252","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2406","original_object":"UniProtKB:P22462"}
{"id":"93fc0e2e-84e1-4671-93db-e1bc85ec19e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6186","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:d5ecc4be-8b1a-4475-b762-760da4912774","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6186","original_object":"UniProtKB:P35414"}
{"id":"918a6749-4b45-4b92-8d2a-9f9803570c68","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:04XB9TB8OL","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:79b0420c-ab4b-4c75-9e19-629cc021fd15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9277","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"8f7321fd-99fd-4c07-8d28-524ead6b575b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NCS2VAH93R","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:a5f8fe4b-efc7-457c-a896-7ed5a3c01f33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8436","original_object":"UniProtKB:P14416"}
{"id":"8b977cd1-f3e9-4f77-810f-95cfd35cbd34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801160","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:2a10a10a-c56d-4265-bc9e-959ef31a0739","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9699","original_object":"UniProtKB:O43318"}
{"id":"6d869911-2473-460d-a0d0-dbc0f7c49ce8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75658JDG29","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:93018be1-7719-497e-9627-006c5c5c987e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12720","original_object":"UniProtKB:P42338"}
{"id":"a690bbc3-e30b-4c77-9150-adba719b8ff1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:6793","sources":[{"id":"urn:uuid:bfb09961-bd26-4f17-928d-e19c2fa4d804","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:O94804"}
{"id":"85e3a312-c222-4be2-8325-6466311b36ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7N13IK9LNH","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:b85af0f5-8fe5-4266-ab8c-f6eefeaa6a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10354","original_object":"UniProtKB:Q13535"}
{"id":"d1a2efcc-380b-4852-a087-65238d78f53b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5707","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:0d0b203d-5b80-4159-a5f5-f18a06d7a301","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:323","original_object":"UniProtKB:P08173"}
{"id":"01d7d008-e5de-4cdd-9360-a1440ebb4324","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131152","predicate":"biolink:affects","object":"NCBIGene:10765","sources":[{"id":"urn:uuid:75ca7b83-6d46-4418-9d80-0b843aa4bd10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7027","original_object":"UniProtKB:Q9UGL1"}
{"id":"d23c320f-68af-4e33-96f8-8abc28b4de94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3892","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:e0cd5dcd-3720-4f60-9539-dcca60026c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3633","original_object":"UniProtKB:P33032"}
{"id":"2cf064e4-bc8f-4f12-8835-835255685c51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10832988","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:5deafe7d-4139-4fb5-ae48-ab0b345ad613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1957","original_object":"UniProtKB:P43088"}
{"id":"1c34d51d-a42a-49df-82fb-a09d763cd464","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827355","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:30618b5c-ac66-4ec6-8160-6b6c7c6bf9a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8384","original_object":"UniProtKB:Q16581"}
{"id":"0cf91947-d053-4be7-acaf-b4ddbda7a698","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121499171","predicate":"biolink:affects","object":"NCBIGene:54454","sources":[{"id":"urn:uuid:81bacce1-f66d-4c45-9945-e3ea7dab65fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9521","original_object":"UniProtKB:Q9ULI0"}
{"id":"2b1e7a70-8829-4aa1-b95a-18dc5f1c2f98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:127534","sources":[{"id":"urn:uuid:af12e5bc-735f-4c19-9cb6-b4571f757878","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q9NTQ9"}
{"id":"43eb3d4a-af9a-4783-b932-8e36afd707ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45713","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:e22c855c-3e30-44fe-b16f-c8f94653add7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8741","original_object":"UniProtKB:P35354"}
{"id":"6cb2b31b-65d8-4fcf-bead-49f7f5ac7817","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44370460","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:c6b97b01-63a3-4b59-b342-8bfededde0a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2969","original_object":"UniProtKB:P51639"}
{"id":"1b667876-b8e8-476d-b9ba-e08e27f9141d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5748434","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:3b377c3e-3d4d-4003-85ab-2308519481c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:899","original_object":"UniProtKB:P30553"}
{"id":"1998b6ce-81d6-437c-9e28-7552c696485a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18295","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:d9094b6c-9a48-4c9c-a46d-e9a89ae3656e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1204","original_object":"UniProtKB:P35367"}
{"id":"69177f71-d92a-4d6f-b995-379627b81a6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11824289","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:1965fe7c-002c-4c0c-b1f1-78956122b12f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4094","original_object":"UniProtKB:P47869"}
{"id":"6bee141f-709f-4289-93bb-a94b20841fd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:5a68a8be-3a5a-4e16-a180-5ec6c4a3f7f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:P50613"}
{"id":"a38c2116-7dc0-4460-9d9f-231609f525be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:150782011","predicate":"biolink:affects","object":"NCBIGene:7398","sources":[{"id":"urn:uuid:47adccc8-ab87-4963-bd21-ec04a782568a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11964","original_object":"UniProtKB:O94782"}
{"id":"bd64db36-8ce6-437c-90b3-a3e8b03a78a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:63464560-d0ae-4cc3-89a8-e633eeddb2cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P31388"}
{"id":"25c660af-0ac7-4aab-9120-7b222dff5e44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46883775","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:c119f540-cfc5-4875-b7e7-ec29cabe6e54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11095","original_object":"UniProtKB:Q16539"}
{"id":"8b33978d-5ab4-4fb4-a246-e9522b392e93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231416","predicate":"biolink:affects","object":"NCBIGene:25248","sources":[{"id":"urn:uuid:7f85ea0c-4c0a-4edf-8052-67c662ac3f2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9257","original_object":"UniProtKB:P20272"}
{"id":"16509ec8-0d1e-4f50-b971-7735f8f684b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135377","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:eea7085a-7638-4fef-9316-d533af9da76a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:552","original_object":"UniProtKB:P07550"}
{"id":"5b3658e7-8911-4e69-983f-1dd566846053","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7465","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:cefef29f-d04c-468b-beab-562eecb78519","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1639","original_object":"UniProtKB:P35372"}
{"id":"c8f071d1-a901-4707-9dee-f14828e0692f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136237316","predicate":"biolink:affects","object":"NCBIGene:8658","sources":[{"id":"urn:uuid:042fe101-18f5-48f0-b32f-01ff860a6f56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10674","original_object":"UniProtKB:O95271"}
{"id":"b409c10d-28f5-4e89-ba31-788d253c22cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27974","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:6c392294-0d19-4f27-ba15-4100dbc1e6c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2821","original_object":"UniProtKB:P03372"}
{"id":"9467339b-e8bf-418d-865f-ed768b72fffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10046145","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:a39f4497-b696-47a6-b950-6efb8f59ddd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5610","original_object":"UniProtKB:P25099"}
{"id":"125d7594-cda2-41ce-9549-580dafa07d77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:5298","sources":[{"id":"urn:uuid:8aa28208-0cbe-4d5c-8d46-7474946c4297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:Q9UBF8"}
{"id":"4ae20b48-0ff9-4ba1-bbb9-4b6c20044c78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:2103","sources":[{"id":"urn:uuid:b3835041-6b97-4a46-acbe-30d4d8361ce9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:O95718"}
{"id":"4463f8c1-3017-4a6b-934b-1445bc4475e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177650","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:cd688c21-a323-4319-94fa-4c2b3c62bb57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9654","original_object":"UniProtKB:P04150"}
{"id":"ba65250d-b971-4b06-be7c-b1abc9e08930","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:9312","sources":[{"id":"urn:uuid:ae2250ed-fe85-49ba-a92b-0bb7dddebbec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:Q92953"}
{"id":"c60f3ef4-ea8b-4479-930d-8e7f637a4e66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46868971","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:9d38ba0f-45f7-4f6c-81bc-482effaf91c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8159","original_object":"UniProtKB:Q96GD4"}
{"id":"4d7d4d7c-68e3-4960-a724-9fb02112a351","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U2H19X4WBV","predicate":"biolink:affects","object":"NCBIGene:57396","sources":[{"id":"urn:uuid:88b31ee7-8baf-47d2-a03a-5c9a650b6de0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10167","original_object":"UniProtKB:Q9HAZ1"}
{"id":"f79e38b3-4d20-45e8-9f7d-b416243e5c28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136042","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:f35313ed-0cfd-4955-aaa1-4aaf8312b0ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9906","original_object":"UniProtKB:Q86TI2"}
{"id":"440a2be4-ed78-4498-8dd4-e461222a9c91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4463007","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:58e4354c-fde3-485b-8b8c-6aad02ef630a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10527","original_object":"UniProtKB:P29597"}
{"id":"ca4cb4d4-26a0-4ad3-8417-fa6286ea75eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8435","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:18f14dc8-0744-4f03-b66a-9b3ed4ed5297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7279","original_object":"UniProtKB:P14416"}
{"id":"f02af499-2ec9-425e-aba0-91275f0f0936","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:85473438","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:9612a402-0395-4727-b7ff-0364a27849e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10291","original_object":"UniProtKB:Q9UBN4"}
{"id":"c9b927b4-319f-4a38-a5a1-dc08b24e7c32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16284","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:e2f15a71-9b44-488a-a06f-e977ed57fbe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1760","original_object":"UniProtKB:Q96G91"}
{"id":"58177c71-c71b-44da-8f3d-e9be09c0ecd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:16485","sources":[{"id":"urn:uuid:8e17df19-bc71-4edf-a805-0cc8e22fa010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2486","original_object":"UniProtKB:P16388"}
{"id":"3be37e6f-6870-4b8d-a93f-018204103b3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:189762","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:406279be-be63-4d64-a536-26ae15c2ff32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1764","original_object":"UniProtKB:Q9BPV8"}
{"id":"0ea59089-93ff-4180-901d-466827658b98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:74545","predicate":"biolink:affects","object":"NCBIGene:79017","sources":[{"id":"urn:uuid:f9e19f65-c5d8-458c-8c59-124aa0b3914c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11402","original_object":"UniProtKB:O75223"}
{"id":"d7f5f26c-c77c-40d6-93d9-2f91b90a8482","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6272","predicate":"biolink:affects","object":"NCBIGene:7054","sources":[{"id":"urn:uuid:c820e26d-3a07-47d0-86e0-782e0172569a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5117","original_object":"UniProtKB:P07101"}
{"id":"82297a04-3693-4294-a6f6-b14c8591b0b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34468","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:079ca98c-c770-4fcc-9e2f-63ac62320feb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4081","original_object":"UniProtKB:P42262"}
{"id":"2077e528-ee2e-458b-b83c-061644e03b2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:175753","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:c4bca269-58c7-45fd-824f-2ef5630d42a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:470","original_object":"UniProtKB:P30543"}
{"id":"d93ba8bb-59ca-48fc-a4c2-12b87b954721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25098573","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:2de97e0d-0de0-4937-9eed-c6eea846b58d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5587","original_object":"UniProtKB:Q5NUL3"}
{"id":"2b557133-7339-4949-bab9-9cce29c3b82f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2272","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:347743e0-fdbe-4a94-852e-27da1563cb99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2272","original_object":"UniProtKB:P32241"}
{"id":"b0a8bbff-2f5e-45b1-b672-19f72c24055a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91108","predicate":"biolink:affects","object":"NCBIGene:130399","sources":[{"id":"urn:uuid:2a1333b8-cf0e-4c6f-a4b5-9684df68a6ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8216","original_object":"UniProtKB:Q8NER5"}
{"id":"89e9e93b-d956-4078-8ac9-0c79ca5cead5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:33182ac9-a978-4b06-8d5f-3e92d5070abe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:317","original_object":"UniProtKB:P08483"}
{"id":"dee28d92-d127-4245-b5fd-dd5fbace9ab5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39585","predicate":"biolink:affects","object":"NCBIGene:1644","sources":[{"id":"urn:uuid:51601469-353f-4788-8d72-2974684dcbd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5159","original_object":"UniProtKB:P20711"}
{"id":"3bc30f89-607d-4072-ba27-83d01d199f26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10588","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:4f3d660e-48ce-4e45-880b-2340ef97a9a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:142","original_object":"UniProtKB:P14842"}
{"id":"512ea429-d677-4e3a-8241-064e385acd4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122703613","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:86ca0229-bef4-45f1-a62e-1fd3362f7e54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10132","original_object":"UniProtKB:Q13546"}
{"id":"a3808fc4-2833-4242-a777-d448a434a0b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:edf203bb-bf32-4dac-b805-b82012ba5781","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:P50750"}
{"id":"67d2c979-b863-4837-9fd1-48d9696e3c71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911338","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:96cf022b-fe6f-47ea-bf2c-c0ec71dc0cc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10437","original_object":"UniProtKB:P31751"}
{"id":"d694b783-fdea-45fe-898d-f248cf943866","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:3cc5eb86-39d9-4850-9e50-00f51d196c07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:P78527"}
{"id":"c18e180e-e1c4-4503-9d2d-3b7afa269a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Y9ESM282DO","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:f5c9b280-6137-48fe-91a9-ce0bf013dde4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:985","original_object":"UniProtKB:P21918"}
{"id":"9962e936-5b7e-4245-969b-a3552922695c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135530","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:7d0d6d0e-4793-4791-b56e-c5c4335d1eab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7483","original_object":"UniProtKB:P08173"}
{"id":"86bd3a4e-eae4-4b74-b1a0-82770df2ebd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132552","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:10134a58-fdc7-4b5e-8bca-6603a7742861","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:110","original_object":"UniProtKB:P28222"}
{"id":"6d05506d-2a08-4c52-b2c3-c106ca4c46b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85662","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:b2bd5c5e-d84a-4451-a087-cf48847a017b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7387","original_object":"UniProtKB:P43220"}
{"id":"fcec374c-f5f8-42f0-8135-68cec42be0cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12513","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:6385f1ba-10cd-4717-b409-43c443ac2fb7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12513","original_object":"UniProtKB:P21730"}
{"id":"cbe905c8-25ba-48c8-88bf-3fb4eb5a2271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10400683","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:2de7cec1-44ab-4464-a927-0ccd0dfeada5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6448","original_object":"UniProtKB:P41594"}
{"id":"81f1e31d-6bb6-4cff-bba3-aac164bd6db7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:74MLR03FLC","predicate":"biolink:affects","object":"NCBIGene:6554","sources":[{"id":"urn:uuid:ee8e457f-8e51-4479-9b1f-5834e77d385c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:63","original_object":"UniProtKB:Q14973"}
{"id":"c80af373-d682-4c2f-af85-d70a9abdcf7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16129665","predicate":"biolink:affects","object":"NCBIGene:24167","sources":[{"id":"urn:uuid:8dd36cd2-5ccc-4316-b209-9bf8e85009e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1155","original_object":"UniProtKB:P32215"}
{"id":"d023c8fc-052f-4f2c-b098-4d682460a151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1470","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:e0542744-b065-4bc2-bfcf-037f3fb04506","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1470","original_object":"UniProtKB:Q9GZQ4"}
{"id":"632391a8-aad3-4f42-97ea-0d9bc923f43e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132992142","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:0099f543-e645-4e7c-95b2-f764c0aabc31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9929","original_object":"UniProtKB:Q15303"}
{"id":"9ecea019-dc18-43b9-96bd-f5c97bbf7321","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6852167","predicate":"biolink:affects","object":"NCBIGene:5298","sources":[{"id":"urn:uuid:3887fdcf-ec0b-4afe-b985-66d82fe5b7f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6062","original_object":"UniProtKB:Q9UBF8"}
{"id":"93e26256-8ab9-4a72-88f5-1286f59a9890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1990","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:c2034718-881c-472c-9938-774739597e30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1990","original_object":"UniProtKB:Q8WXD0"}
{"id":"d85e0753-0688-41cf-b643-b614c4938ab4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321148","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:1bdb5941-dbbf-4db1-9cb1-c4dbcc6fb537","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10108","original_object":"UniProtKB:P06239"}
{"id":"74a343de-539c-43aa-a728-688a70909b82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZN0X0Q76F1","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:591f9c40-bf52-4b4a-82b3-6c79fad30cdb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5965","original_object":"UniProtKB:Q15303"}
{"id":"f83eb54d-dcd9-401a-8b6e-304d2a9705b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8931","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:cad79de1-5d51-4888-9961-997380e5ca83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8931","original_object":"UniProtKB:P04626"}
{"id":"ac306f0a-226b-4552-b847-8536dbb68b7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1328","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:a43652db-6778-408e-b81b-273c189498a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1328","original_object":"UniProtKB:P41968"}
{"id":"6a143040-63b7-4823-a525-8ff60c256208","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53340664","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:680aea2f-90a7-4644-9691-a12497bf9166","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8074","original_object":"UniProtKB:P12931"}
{"id":"750925f8-ab2f-423b-be35-45e100796aae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137364063","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:c6258a96-e72d-44e7-9a72-74fbe02e2d6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12170","original_object":"UniProtKB:P21728"}
{"id":"460ce3fd-1e80-4d3a-82a6-96d208e9f089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78320","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:63be2efb-b4e5-480b-bfe9-c5ab63cc3361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2932","original_object":"UniProtKB:Q9BXC0"}
{"id":"54718e15-1c49-42a7-982f-adbe293ab54a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030528","predicate":"biolink:affects","object":"NCBIGene:3690","sources":[{"id":"urn:uuid:8bfdeff1-ca6b-4bfb-a367-b79f64316e98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10450","original_object":"UniProtKB:P05106"}
{"id":"3dd4e944-027f-4895-8da7-bb539c14b372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54760053","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:e9138764-b667-4f7e-8031-0ed07a2c352d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8095","original_object":"UniProtKB:P36888"}
{"id":"777f0ba2-5755-4b95-b206-4d91ec17f6bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91418","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:3757dad9-4407-4c14-beba-fcfa80ce7328","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5679","original_object":"UniProtKB:P35968"}
{"id":"0f0680f4-b2ef-4a06-83d3-e69d25e896f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167673","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:0887db22-2654-41f1-acb9-81d11cc8158b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10387","original_object":"UniProtKB:P09619"}
{"id":"a3154d6f-6763-4797-97c3-a64301ba111f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CJN36EQM0H","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:e05535bb-e2d1-4b43-bb9d-68a66543a1de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9662","original_object":"UniProtKB:P04626"}
{"id":"42f3250c-c10b-4ce3-b7de-c49fa3455f5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230506","predicate":"biolink:affects","object":"NCBIGene:200576","sources":[{"id":"urn:uuid:58e06ea2-dfaa-43f8-8363-0cdd56baf5de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9859","original_object":"UniProtKB:Q9Y2I7"}
{"id":"be27f39d-b2ce-4aba-b970-6f5e6cd2ca46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T61871RKRI","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:0f70d6cf-60f4-41a3-965c-b9627644e820","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5707","original_object":"UniProtKB:P11802"}
{"id":"c8d17578-08bf-49bd-8e6c-cd4bde3bf170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8435","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:051c1877-33c4-4a39-b252-28cf491ad04e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7279","original_object":"UniProtKB:P35462"}
{"id":"8549e24f-04de-48c7-aacf-e90749ab9df0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232982","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:7bc126f6-8840-4670-9c8f-21de91bccfe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:188","original_object":"UniProtKB:P28335"}
{"id":"ee11f395-ea54-4e68-98e8-67a696267a62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42491","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:9834c615-75f8-48a7-8602-451354dcff04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:409","original_object":"UniProtKB:P29274"}
{"id":"19d7649b-02f4-4fbe-932d-c39c586e8f0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1997","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:635144cc-bb91-41c6-a945-bf629d31624b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1997","original_object":"UniProtKB:Q9NSD7"}
{"id":"d5eb1ffd-323c-43d2-af2d-8ec33f8f9bd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755185","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:3ba00df5-ab80-4dd8-a43d-f684cdbc158e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6194","original_object":"UniProtKB:Q9NS75"}
{"id":"0fa4cfff-77d3-451d-9623-535038840332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:29250PP3ON","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:bf060e6e-cee1-4ee9-a352-b35d7d1805cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7860","original_object":"UniProtKB:P43235"}
{"id":"56362cfe-d41f-4341-b8fb-639d189bad10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:173871","predicate":"biolink:affects","object":"UniProtKB:P18901","sources":[{"id":"urn:uuid:fb62a537-b8d0-4908-a14e-a100f7807386","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:936","original_object":"UniProtKB:P18901"}
{"id":"7022f11d-e864-406d-a01c-07fa547b8b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118701008","predicate":"biolink:affects","object":"NCBIGene:23043","sources":[{"id":"urn:uuid:10727f24-0040-4bd3-aba9-c825eb4fdee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13265","original_object":"UniProtKB:Q9UKE5"}
{"id":"c0604e1c-7d67-4099-b6a8-ed955e86593c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:1856a4b4-e503-4d40-bc2e-44e5d429b0be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2522","original_object":"UniProtKB:O95180"}
{"id":"31ce43fe-02c8-48e7-816d-6fe06e9a1e20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23656549","predicate":"biolink:affects","object":"NCBIGene:3276","sources":[{"id":"urn:uuid:2fe57921-5d59-4bc2-a001-a783d4e471fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7029","original_object":"UniProtKB:Q99873"}
{"id":"40feb9b9-efcb-4615-95f4-4faf482a09f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50138","predicate":"biolink:affects","object":"NCBIGene:100359982","sources":[{"id":"urn:uuid:49b67f51-3269-4231-8b4f-43ff539b392e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12601","original_object":"UniProtKB:P38718"}
{"id":"56832a3a-6c41-4fe0-9068-7a240b31e5c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10813088","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:c50ea769-464d-43f6-ad74-9a199c982753","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:398","original_object":"UniProtKB:P29274"}
{"id":"f45683f3-b422-4401-857b-76833891d339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182364","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:bf0f521a-f087-49cb-bf02-819e8b5c1ce0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8144","original_object":"UniProtKB:P36897"}
{"id":"9adc2233-6308-41a3-bc1b-4bc586121b05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134191471","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:a3b8d282-9ade-44df-9fbb-e65286ea9493","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10135","original_object":"UniProtKB:Q14833"}
{"id":"c87c7df8-af5b-4810-812a-6eedc5bdd85b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:178a73e3-cb87-48fb-9771-5088d8d3094f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:O15379"}
{"id":"35926b90-056f-420e-ad5f-68068156e96b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28821","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:da6f124f-b1a4-4f5c-aa3b-09d0787ecfe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2489","original_object":"UniProtKB:Q8NER1"}
{"id":"a12c2ddb-7c0a-4742-9b4a-d24fdebd8969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16660135","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:d5558233-8257-48e1-93dc-3ac9e8f79dec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8767","original_object":"UniProtKB:P23385"}
{"id":"70d79798-2fc5-4609-9d0e-3598c65a3e75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10098735","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:899ed8cf-a24b-4cc5-b140-c743286924a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:789","original_object":"UniProtKB:P51677"}
{"id":"b1640248-08f1-4b06-9be9-213fc5404004","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90933","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:19f87e56-f16a-4353-bd73-34938e3950b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7671","original_object":"UniProtKB:P35462"}
{"id":"49b9cae3-8dbe-4aef-bb0e-83bee5e14068","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137367538","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:c8a71e5d-0320-4fd5-8aee-dbc061323ce1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11960","original_object":"UniProtKB:Q86WV6"}
{"id":"9504cf0f-adde-4901-a639-a9cbee1a1676","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83531","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:231df734-fd78-4138-b95e-b684068499d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7428","original_object":"UniProtKB:P27338"}
{"id":"7fae6ca6-e3c7-4c7e-a125-3b82d5423703","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AIQ4OWD0RA","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:ba358d41-e7b8-47bf-a188-6db2070b8701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8527","original_object":"UniProtKB:P42338"}
{"id":"aa1b88eb-b436-43df-8ce0-601dbffb574d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"UniProtKB:P52188","sources":[{"id":"urn:uuid:092c99de-8612-453d-92f3-87eab484689e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:P52188"}
{"id":"ab3c51b3-b71f-47c9-8a00-2aa428f38b9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110176","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:6a694167-4bdb-4dba-ad89-0682e25b5deb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3264","original_object":"UniProtKB:P08173"}
{"id":"fdaebb43-327d-4612-9f14-c1301be60ac2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PY79D6C8RX","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:61479e0a-a91c-4c3c-8891-6052268274d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7453","original_object":"UniProtKB:Q5XXA6"}
{"id":"ef231049-3538-454a-addf-4bf11080d49a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311134","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:41c6196b-f10c-457a-abe2-4ba36c70005a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1349","original_object":"UniProtKB:P48039"}
{"id":"b8599a63-3821-48d2-80f8-5daf70c452ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:4194c6f2-f8ab-4721-b002-968953c5f775","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:343","original_object":"UniProtKB:P20309"}
{"id":"4c2b8692-0833-46bc-8f5a-7a7cdb9fa0dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035228","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:5451cd2b-3591-4f4c-94f9-3c6c85a0ee8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4324","original_object":"UniProtKB:P51575"}
{"id":"dd860800-aaa6-4c95-8482-8f35aaeb00b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53868701","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:3d46815c-9734-47c9-afad-e02065e601eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9529","original_object":"UniProtKB:Q86X55"}
{"id":"b5575707-2efd-4f20-aa96-2468ac7bba2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:3055","sources":[{"id":"urn:uuid:1f0e1928-209b-4f9f-8b3b-b08a0be691c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P08631"}
{"id":"40a9e0d8-8a46-4053-ab18-0ae8f945d3a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311092","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:955bc85b-0918-4e97-8356-96f1ac434a38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3530","original_object":"UniProtKB:P51677"}
{"id":"2f2ab0b4-367f-4bea-92ec-a3b2b1ada0c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925847","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:6d8d0f4e-55a8-48ed-b650-887b27b7138b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11543","original_object":"UniProtKB:P0DTC1"}
{"id":"f9657444-133e-4780-a45e-79e7c7c0fa58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947030","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:d389db73-b7db-43cf-a972-0f163520623a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3010","original_object":"UniProtKB:P04035"}
{"id":"72fb883e-c425-44d7-afb6-efbf6a2a3688","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1821","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:416fec3c-6163-4b1e-8efe-8f12e2d526ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1821","original_object":"UniProtKB:Q03431"}
{"id":"08dbbaa8-40ba-4e97-8738-1e42dfc893e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7568","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:e5cb8629-2315-4bcb-ba90-53ec5e73d593","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7568","original_object":"UniProtKB:P35498"}
{"id":"1e707d79-d917-4337-a286-04ed1be14d8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5838","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:76dffb13-0ac9-4b40-8a26-b48799056b55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5838","original_object":"UniProtKB:P21462"}
{"id":"69805f53-018c-4640-a5cc-dd7d6db94781","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94691","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:3898949a-aa64-42f9-90ae-75f6b95fc3fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5715","original_object":"UniProtKB:O00329"}
{"id":"ed4be5c0-9f94-4fee-a9ad-3f4d511f6032","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65353","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:185521a0-45ba-4045-a6ac-a58bbe37ef7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2941","original_object":"UniProtKB:P41595"}
{"id":"667ff4b8-ae63-44e0-be9b-80557a7107f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9989449","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:3be95512-5799-4cdf-b17b-23ead5861023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1260","original_object":"UniProtKB:Q9QYN8"}
{"id":"36bf376b-cfeb-435d-9691-f42a4d1603db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W34UO2M4T6","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:24704484-4f4b-4f41-b0cd-a42c169b5daa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5661","original_object":"UniProtKB:P07949"}
{"id":"a360e315-1141-490f-a8cc-100669535616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:f24e2d2a-9bb1-4c72-a931-f3e8ea623c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q6RI86"}
{"id":"79e21cef-ad4d-4b25-ba6c-93790b41b14c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SIS5BFO4WL","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:a1c92253-2a59-44bf-ac72-32248b25017b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8427","original_object":"UniProtKB:P41595"}
{"id":"70fd0752-20ef-4231-8645-1f588a6e9521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J9F5ZPH7NB","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:cc412cc8-42a5-4ea8-82a9-5542cf118ba7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5858","original_object":"UniProtKB:P35408"}
{"id":"869837f5-085b-4258-9ff9-ad1c82f1dc89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:cb28df2b-8e0c-4595-857c-8a419ed09f8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P35375"}
{"id":"b96cf26f-04b6-4964-9697-631f6ff508b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2620","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:c7a815ba-b42e-4c2e-81ff-260ebe60b085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2620","original_object":"UniProtKB:P04775"}
{"id":"e0e237b3-90de-4814-aa27-115bb6334acc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5193007","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:7daafc11-fd57-4840-b18d-e3d4ce6cfb1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5943","original_object":"UniProtKB:P49841"}
{"id":"2da373d8-b248-40ca-8240-96cd8a01f6ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3601086","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:6c1356fa-e257-4bef-ba0f-fe09698381c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4294","original_object":"UniProtKB:Q9EPK8"}
{"id":"3332557b-4dcc-4982-98d4-d03918655b96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3783","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:97afa5ee-4644-480a-981d-3b7f3836632d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3783","original_object":"UniProtKB:Q02644"}
{"id":"e448d880-e498-417a-aa8f-6bc19d4f220e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5352127","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:b464c6c8-e7ab-4251-a3ea-d68107042e74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3227","original_object":"UniProtKB:P08908"}
{"id":"6da6aa11-5534-4a55-b1f8-5f8d86228c74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3596","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:80e91788-d01e-4800-8cd4-b63bf068aff2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3596","original_object":"UniProtKB:O88626"}
{"id":"d9083354-52f6-47ec-bbe4-09afd8d1d347","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85994","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:2fa41755-3a80-4e6a-8b88-8b6e9635295a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7426","original_object":"UniProtKB:P35968"}
{"id":"5307060c-22f3-4ab0-a0a4-6753bfbdba83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:3355a3d6-b69f-49de-b1ff-1edbfd61f4bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P08908"}
{"id":"1e9c25f8-55ad-49fa-91b5-6c2042eb1e6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109558","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:af68bf53-7f42-4fb8-9a32-bf444f601951","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1343","original_object":"UniProtKB:P49286"}
{"id":"986818c2-3870-49e8-99d6-280e8607f1c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600321","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:7551ea93-a740-4c06-ab2c-45d701cbed54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12915","original_object":"UniProtKB:P40763"}
{"id":"556f1b9e-aa26-4eae-ab0c-c60f0f381260","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:f2f477e5-5fcf-4741-bfc7-e4af50781089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P29276"}
{"id":"4981bec6-2e89-47c3-9e25-31d272fc25b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:391960","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:a1c8ca2e-f0d3-44d8-b41b-03d641ae02c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:321","original_object":"UniProtKB:P08172"}
{"id":"b91afa39-dd3b-49b3-8960-320a6d2412be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101882819","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:2c51043b-dcc3-4ebd-a2eb-7d1638f625ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11235","original_object":"UniProtKB:Q9Y5X5"}
{"id":"ca94b51e-dad9-4d03-955a-515440625f45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166176959","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:40e2dcb1-7f13-4161-beee-f10675ecc325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12311","original_object":"UniProtKB:Q9Y572"}
{"id":"13c0f688-0727-459b-8869-70ccb1202c60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63619","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:3f676d2d-2640-4a2b-9a2b-d1424005995e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2561","original_object":"UniProtKB:P07550"}
{"id":"815a7085-4d00-4164-9d43-c3992c4847b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11515548","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:76421d8f-53f9-4f2d-b411-3341f75bb205","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6355","original_object":"UniProtKB:P23385"}
{"id":"2d1725bc-4425-4749-9ef7-42dcf4b09b1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3896","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:f6f90208-4f28-451e-a2a2-62300278e127","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3896","original_object":"UniProtKB:O43603"}
{"id":"26a81b2b-f027-4ed8-a32f-510025c62b5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:2705","sources":[{"id":"urn:uuid:16998c82-2599-4e92-a928-d04d9d439ea7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P08034"}
{"id":"95bfe503-6bd4-436d-9eb2-48b191999443","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10136","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:042fa27b-3ba7-4e45-8ed0-04e3e5d1c8b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2428","original_object":"UniProtKB:Q8BLA8"}
{"id":"592bafe3-9914-43ec-8384-950b852a41e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3594","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:d655b174-f0a4-487e-8d5a-c6721e5f1273","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3594","original_object":"UniProtKB:P47211"}
{"id":"4931b426-8922-44ae-a58b-6baefab7b2b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:81d71802-4f3b-4f67-9166-4ef2b245dff0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P31421"}
{"id":"942e4865-7955-49d6-9ce0-1b750758f437","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:841618d3-c7ea-4d89-8846-abfc1e00427c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11859","original_object":"UniProtKB:Q9UGI6"}
{"id":"e036b4b4-f12e-4bd8-8649-cf521d9eee07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:1f5b1998-02bd-4291-97ae-c313651d3cb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P47898"}
{"id":"bc15aad6-e946-4008-98f5-f24fcb1028e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCL936W835","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:53702988-9340-4ef1-b4d6-0a7fe1ffdc7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7743","original_object":"UniProtKB:O00329"}
{"id":"7737022b-ed25-4ac1-aee3-95aef24b946f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2D9N67F58G","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:8bdbddc8-e8f1-40a2-ab6d-79b12b2881c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5691","original_object":"UniProtKB:O14965"}
{"id":"7ce4b0d1-3aaf-4cc3-a481-023245b54dac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1329","predicate":"biolink:affects","object":"NCBIGene:17201","sources":[{"id":"urn:uuid:47dadf9a-82da-447d-b097-edc9d6bdbd75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1329","original_object":"UniProtKB:P33033"}
{"id":"753ce6c1-f7dc-4270-ac1f-75a4057ce4c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46232606","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:b72af5cc-4578-4997-ad20-a053eea12697","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8606","original_object":"UniProtKB:Q99685"}
{"id":"918ca7f8-2058-4592-aff0-2536ae78058c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:2e4cff1c-7dc4-4a60-b723-0d32113e105d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9UGI6"}
{"id":"908acdaf-c47a-49a2-bb68-95c97e2584dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15951636","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:8a2acfb3-4904-475e-8eca-834ecd4599ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9893","original_object":"UniProtKB:P27487"}
{"id":"1d5620ef-248c-48a3-ad50-8ef79ab77551","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:67RM91WDHQ","predicate":"biolink:affects","object":"NCBIGene:1263","sources":[{"id":"urn:uuid:f15e407f-dfe3-4925-9274-6a17a0136c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7918","original_object":"UniProtKB:Q9H4B4"}
{"id":"a9af28b4-6caa-428f-bb78-e05482cbf4df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311416","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:a6e8c04f-4355-427e-8dce-0d9c7a75c0d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:250","original_object":"UniProtKB:Q13639"}
{"id":"838f365d-1d71-4d3f-801b-6484ca3de683","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:4486","sources":[{"id":"urn:uuid:87bd002c-a661-4e13-8d59-0d57bb280ea5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:Q04912"}
{"id":"78b0ab6b-c330-49d7-a8c3-d4459c79b4b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133538","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:3bebb46b-030e-48f6-98c0-44264eaa6d1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:724","original_object":"UniProtKB:Q5T6X5"}
{"id":"089fc658-d40c-4ac9-ba99-32ff8dcd62c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:10ab6f21-cb4e-4742-a1cb-d69411553987","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P32305"}
{"id":"bf46b6e1-9320-4edb-9cf9-451aee30e056","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M4PN46N313","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:9977e07a-b6ad-4f0a-811c-2e2db885f783","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:334","original_object":"UniProtKB:P08482"}
{"id":"e2a357b3-31ef-459d-bb3c-89afabe84610","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1524","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:3112207f-69f1-4acc-81c3-e205ac199ee9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1524","original_object":"UniProtKB:Q63447"}
{"id":"7246a675-d59a-4dc8-b240-aa5606099006","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7872","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:18c616d4-b89d-4dcd-a21a-c03566dd6bd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2174","original_object":"UniProtKB:P70536"}
{"id":"77d07d82-286a-44ed-8fd6-1ab4ba3ab27f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:9871a0da-ee4d-48df-ac86-3685440d51ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08483"}
{"id":"32f3abe7-3a8a-44fa-be59-36b34bf8f440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813885","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:ddb1ff9a-5307-4cde-aadb-02876bfef5a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3891","original_object":"UniProtKB:Q13324"}
{"id":"193cf114-95fe-4a41-b2d1-240dc1a15bcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44349317","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:198ccf92-100f-4ffa-99e1-cd41589a1335","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2965","original_object":"UniProtKB:P51639"}
{"id":"b63ebc02-3b1d-4ee3-9b16-af4e7e0c92d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91327","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:a9cf85e6-bf0b-4d78-bafd-5c14a132fe7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6058","original_object":"UniProtKB:P35968"}
{"id":"76af2177-bdb2-49e6-8f4a-e0b752aed242","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53402072","predicate":"biolink:affects","object":"NCBIGene:3146","sources":[{"id":"urn:uuid:782dc399-857c-4dec-b1a9-27d48ebf1936","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13325","original_object":"UniProtKB:P09429"}
{"id":"07d98e31-3851-4e53-bb64-51e76cff3c2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83766","predicate":"biolink:affects","object":"NCBIGene:10039","sources":[{"id":"urn:uuid:f48271c0-f0dd-4a66-a176-a05abf78074d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7519","original_object":"UniProtKB:Q9Y6F1"}
{"id":"a978c385-3954-49c2-b96a-1e4620b43261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60148519","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:9f6d031a-757a-440f-a068-f74715921628","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6535","original_object":"UniProtKB:P25774"}
{"id":"907f4d80-6b3d-4cff-8c7b-3e72ab511aed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9826034","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:12740831-d382-46d8-86a4-491888e1980a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1669","original_object":"UniProtKB:P41145"}
{"id":"3353fe71-ce97-4bfc-9a37-ef63a9565754","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:41dfd43a-cafb-4678-9b95-c640e7295756","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P43114"}
{"id":"81ff7d6d-6179-49c2-a74c-63442b3afac8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132049","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:c2ee5392-7afe-40e9-aa17-3db8ffdb2b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:180","original_object":"UniProtKB:P14842"}
{"id":"cc107da5-9852-4e88-855d-67f091bd08ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137113","predicate":"biolink:affects","object":"NCBIGene:676","sources":[{"id":"urn:uuid:b2a647a6-0a7f-4ea3-86fa-087670737cc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7511","original_object":"UniProtKB:Q58F21"}
{"id":"8a14c38a-18ef-4079-8b21-e823c00d59b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:d634ff1d-035c-4c5d-a2ea-f4f3fac82628","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P28335"}
{"id":"7f24239f-d950-43ac-9d3c-c394dfa2fc01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91399","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:fe083c4a-203b-4d8c-aaca-1fba22331b43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5670","original_object":"UniProtKB:P06493"}
{"id":"df9cdede-cf37-4673-9e36-8c7cdc7c770f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9125","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:e6a8c352-532d-446b-bb66-9f55c8c20a8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9125","original_object":"UniProtKB:P00533"}
{"id":"dbd2e43a-52f6-43d1-b730-a21af4692c82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233412","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:b6ed44b5-7aeb-4589-8aa6-a500eebe1e62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9320","original_object":"UniProtKB:O95977"}
{"id":"e2e139e1-ca1d-4998-8529-ef410a6dd301","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5267B75F6S","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:a265374e-587e-4f74-8fca-11b1234e5a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6705","original_object":"UniProtKB:P51639"}
{"id":"c39b78dc-e245-4855-9ce9-85b8fedaeac2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:57369","sources":[{"id":"urn:uuid:570ee759-d7f4-4e6b-b35f-15f22b61088f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9UKL4"}
{"id":"56988b17-8e7f-4f2b-94de-5d07ce41893f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9R2G075611","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:5051cdce-fb26-40ba-af73-5939828af933","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8060","original_object":"UniProtKB:Q9UQB9"}
{"id":"719a82f5-90a7-4122-b2e0-689464a600c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:40df390d-fcda-4d16-bdf7-5f1f8f498e67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:Q14524"}
{"id":"02150ad4-fa0f-409e-a4db-cbf984019f1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53466122","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:752031cb-e6c8-4432-8706-cb8e8b64f46c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12943","original_object":"UniProtKB:Q86TI2"}
{"id":"191515df-f737-4889-92d7-81789109eca0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311375","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:b7dfe038-ea95-4229-82ee-1e545ba23421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2016","original_object":"UniProtKB:P30872"}
{"id":"f4baaa14-6323-4a50-af04-60610d2ddcbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139368780","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:ae0846d1-eaf5-4f8e-bfeb-4f292cf1c9c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13195","original_object":"UniProtKB:P07550"}
{"id":"9affe1a3-22e4-45ca-9bad-8c0d601bfe4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452170","predicate":"biolink:affects","object":"NCBIGene:65975","sources":[{"id":"urn:uuid:7f14126a-4f50-4d51-9a85-0151412a785b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8190","original_object":"UniProtKB:Q9BYT3"}
{"id":"cd320ba5-fa15-403d-9c38-fd90545de63f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2044","sources":[{"id":"urn:uuid:d9f1e4ea-c404-4931-b0c9-1557204fb928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P54756"}
{"id":"98e7572a-78c4-405c-af13-66c32982d4fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:171382","sources":[{"id":"urn:uuid:40f9982f-6139-491d-9ec3-61105ebb9c0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q8R4D5"}
{"id":"ff01ef98-304b-4b08-9a93-5305633d3257","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:132cec30-6b37-41c0-99cb-35525c7d41b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P28223"}
{"id":"7409ffe1-f4b5-48ae-895b-4395cf5448a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:764","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:5ad3e250-7a15-4f1c-ae21-47be346b8b25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:764","original_object":"UniProtKB:P51681"}
{"id":"56780de7-f2d1-48cb-8954-2b1ab135bec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8734","predicate":"biolink:affects","object":"NCBIGene:23657","sources":[{"id":"urn:uuid:1f55dabc-38d0-43f2-a7e4-64e85cd6151f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1372","original_object":"UniProtKB:Q9UPY5"}
{"id":"5965d1ad-0fbf-484f-a694-1b407c9df05f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3764","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:8e432533-732b-4464-9332-d24eb1b14061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2330","original_object":"UniProtKB:Q8TD43"}
{"id":"303c0f1e-728f-4846-91f8-fca0144bc905","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6138","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:3da0f047-2b71-49ae-ab75-d30c83960292","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6138","original_object":"UniProtKB:O43603"}
{"id":"49c7edec-1467-4e03-bea4-d4a2444887c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11911","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:3b5391f1-9bd8-47b8-a08d-a785e9b306f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11911","original_object":"UniProtKB:Q9NSD7"}
{"id":"0315e62c-a74a-4276-bc07-36b4c0b1c52d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231416","predicate":"biolink:affects","object":"NCBIGene:1675","sources":[{"id":"urn:uuid:ed7fd0f3-c545-4b75-9ddb-29dc18c11fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11988","original_object":"UniProtKB:P00746"}
{"id":"3f7fd3f6-5866-4098-ab30-2d899bb13b53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890547","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:b759b918-a60a-43ca-a0c2-8c0b1f179043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:490","original_object":"UniProtKB:P43140"}
{"id":"be16f33b-1efe-4cee-be3d-e04800880812","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92418","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:589f6797-9653-4f62-bbc1-105c69a80c62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:295","original_object":"UniProtKB:P20309"}
{"id":"b76ccfec-a8f2-4f17-8e0e-49fc51a5cbf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8058","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:6bb6e223-288c-4d9a-a8ef-0e132a7eeba4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4282","original_object":"UniProtKB:Q14957"}
{"id":"ea83217c-b865-4f80-878d-df3651d19202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CER0OPG92L","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:d8537f7e-f914-4388-b117-87cd4cd26cd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10044","original_object":"UniProtKB:P00533"}
{"id":"f85febbb-4570-4eee-a653-9c0f1ac32e02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57325421","predicate":"biolink:affects","object":"NCBIGene:6197","sources":[{"id":"urn:uuid:e0a2c5be-ca8b-47d0-ba3c-1c03dc2e85ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8139","original_object":"UniProtKB:P51812"}
{"id":"6f1a6150-1430-4112-be52-8071458f5a73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44634573","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:8dac31c6-7b30-46c0-a032-04dd8c8a099c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9168","original_object":"UniProtKB:Q6W5P4"}
{"id":"631d41fa-7cf8-4759-91a6-387d9d21cb7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11158623","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:ed984fed-8b35-4f08-b648-fc6c1fa0a17d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6226","original_object":"UniProtKB:Q14832"}
{"id":"8f27feeb-3e0c-4da0-8a15-9d85a5df9b62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132086","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:b02d0850-a772-4291-aef8-c7c50876ab59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2641","original_object":"UniProtKB:P13631"}
{"id":"e5654493-6588-4149-9381-53d440fc5353","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:272","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:a59dff18-4351-498c-8662-f80b9a45b8ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1647","original_object":"UniProtKB:P34975"}
{"id":"f0831425-9d18-4b9c-ba05-de2bdaa62d73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73378","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:9da31752-b21a-46ae-b310-80ca25dceabe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:206","original_object":"UniProtKB:P50406"}
{"id":"28713b06-3bfb-457c-840c-1940f837f56c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10457630","predicate":"biolink:affects","object":"NCBIGene:6713","sources":[{"id":"urn:uuid:75ae74dc-1935-4292-8be2-6fe60b987298","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8794","original_object":"UniProtKB:Q14534"}
{"id":"db8b666d-be28-46f8-a3da-0f2a02f51453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3175","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:aacf26a6-1b5c-483d-b5f9-0370980886e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:520","original_object":"UniProtKB:P08913"}
{"id":"560b9c7a-d206-484e-bb88-aa6b3f96ee60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129234005","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:930f6be3-1ef3-4908-8f68-4c2566dc9444","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12239","original_object":"UniProtKB:P51451"}
{"id":"48810495-1d60-4617-a383-c04477737531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10015055","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:fa677390-7319-42a1-9c6d-7f997a8f0a2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1212","original_object":"UniProtKB:P35367"}
{"id":"c608c42e-c9e7-48a6-8fdc-fff7c66939bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231615","predicate":"biolink:affects","object":"NCBIGene:6789","sources":[{"id":"urn:uuid:45913cb5-6a4a-4719-a660-53d13b2f287e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11812","original_object":"UniProtKB:Q13043"}
{"id":"119302d6-8920-4a1d-ac0d-5157e92199c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:1b84b900-a90c-471e-a7cd-a97b573b49b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:O14757"}
{"id":"61891811-d6f9-44f9-87f7-d4fef393cbe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:12374","sources":[{"id":"urn:uuid:f0780f14-5aa7-4e4e-9701-35d62420fe2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9QY96"}
{"id":"2eb359ca-5f1c-4055-adc5-7cf6d0d3db2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL3764617","predicate":"biolink:affects","object":"NCBIGene:56848","sources":[{"id":"urn:uuid:31f2b758-d55e-4b23-9793-1ae0ad76e9f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10219","original_object":"UniProtKB:Q9NRA0"}
{"id":"824f774f-9906-4123-8386-b9bee791a42c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45380979","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:5cc7a8aa-a7b9-4dfe-8453-60c1459d108c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7874","original_object":"UniProtKB:P24941"}
{"id":"e4489d7d-775c-4491-ad86-c073dbd79d4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:7938c02a-c7bd-4990-a64a-61c7b05971fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P31391"}
{"id":"95fff551-6b1b-404c-a752-475450b01bdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94504","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:3c0f44db-26c6-4556-822e-975d58d6a510","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8464","original_object":"UniProtKB:Q9UBN7"}
{"id":"c627d04c-b21a-4715-8f77-a45990eea719","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A7CGH459FN","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:a113b750-6c7f-4c85-bbeb-749b6ba5188b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12766","original_object":"UniProtKB:Q01959"}
{"id":"9514ad90-461a-40f9-b45f-47ffd46e2d09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121322599","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:9bed72f8-d9b6-4ce4-8c2b-3ae6ce740bcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9332","original_object":"UniProtKB:Q15910"}
{"id":"31caeb80-574f-4c38-a485-51530f7b7452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B67UFT75QS","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:d4b825ee-9cba-4f14-9b06-4fd316ab2f9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9821","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"e95417bf-eb74-4670-8b44-7d79d6548b4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2772368","predicate":"biolink:affects","object":"NCBIGene:112","sources":[{"id":"urn:uuid:859ae76e-f6ea-4160-836a-4f6b28a8cbfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5233","original_object":"UniProtKB:O43306"}
{"id":"53759f1e-6069-45df-a3db-7c45cef7f189","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:ab5af3ad-c04e-4e59-b84a-ae62a02b231a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q9UKV0"}
{"id":"bf64906a-023f-4572-a0bf-fd906003489a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:7e11bfcf-d32a-4c11-8064-0f29374bed1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P28223"}
{"id":"4a49fb62-136c-40f9-b3f5-9ac81a48ef1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9067","predicate":"biolink:affects","object":"NCBIGene:24603","sources":[{"id":"urn:uuid:28da2cc2-d3ce-43bb-a290-a167b0fc8c56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9067","original_object":"UniProtKB:P18910"}
{"id":"0cec2a86-4332-48a8-8192-7d9352f9db87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3603","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:1da812f8-36c1-4b09-9f2e-ca54fc9e12e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:308","original_object":"UniProtKB:P11229"}
{"id":"876b4a97-2897-4ab2-b0be-c38ecea28692","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:6cb68b72-9ffb-4389-b2e6-95d5b18b093d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P08908"}
{"id":"80f19009-6ec6-4d44-a5e8-5c1ca4af941e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164861551","predicate":"biolink:affects","object":"NCBIGene:56659","sources":[{"id":"urn:uuid:9f7ea93c-7881-4999-a5d7-82a7df51a772","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13373","original_object":"UniProtKB:Q9HB14"}
{"id":"6b9308ac-9838-4461-bc4d-2d6f1489061d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827348","predicate":"biolink:affects","object":"NCBIGene:9934","sources":[{"id":"urn:uuid:086f0831-fbd9-4276-b450-25b4510490ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5908","original_object":"UniProtKB:Q15391"}
{"id":"4438706f-c7a5-4581-a423-7bbabfba465f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27584","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:55c654a2-77d6-4ae3-80d2-ab83e870371d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2872","original_object":"UniProtKB:P08235"}
{"id":"94e88179-4729-4193-bd94-53cab7c9d807","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132086","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:f7b69116-369a-444f-ae75-dd46e1459499","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2641","original_object":"UniProtKB:P10276"}
{"id":"4ba85b01-8594-4f64-a103-8da75e19f7b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15234606","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:6af3a301-7523-4d8a-96d1-1143ddb1acf2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10226","original_object":"UniProtKB:Q16581"}
{"id":"96cd95d9-d4ad-4e28-ac7c-ce4ad0fc7094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3699","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:3f1c0871-09c0-4e98-9354-fd0a48c987ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1231","original_object":"UniProtKB:P25102"}
{"id":"11dfc268-fbd4-4f1f-9b34-e231ebeada38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44134520","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:13f1fd55-8d8a-4b8b-9397-ab00dfb7ba34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2257","original_object":"UniProtKB:P30083"}
{"id":"b89dbd8c-68fc-47d2-842f-683bf272896c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:fa28ff47-f96a-44c7-a1f4-e7c04e93f1ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P08913"}
{"id":"8d15ac62-f319-4f08-afd9-0057d89fa277","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2170","predicate":"biolink:affects","object":"NCBIGene:25108","sources":[{"id":"urn:uuid:4eba3b70-0546-4d7a-b193-d62fdb11d8d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2170","original_object":"UniProtKB:Q00788"}
{"id":"2e473388-02e1-4c72-9381-03fa5053767d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90448438","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:a611a87e-255e-49ee-b49e-b264bcc57346","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10089","original_object":"UniProtKB:Q13546"}
{"id":"2131d9f2-539b-4633-a689-f51c51e9be8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699459","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:8c0f1ca4-8418-4afb-b5b5-bf63f6571320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11198","original_object":"UniProtKB:P04629"}
{"id":"6ce4f105-7c21-43d3-ac12-7410046a8334","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18437138","predicate":"biolink:affects","object":"NCBIGene:1230","sources":[{"id":"urn:uuid:e359bb73-14ba-41bd-a99a-c4f8a35db492","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10750","original_object":"UniProtKB:P32246"}
{"id":"761e4235-9af9-4259-ab13-94020fcd5cb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9137","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:efebb0dc-5ff0-4337-84e5-6ba081e364e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2586","original_object":"UniProtKB:P31645"}
{"id":"a276473a-041b-4f63-9c1e-cce7bf8ca0f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6498","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:7a865222-faf9-4329-b370-3eae16ee69b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1034","original_object":"UniProtKB:P25090"}
{"id":"f49cf4cc-412f-47eb-800c-f76d4e6e2eee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34146","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:4d88c6a6-07cd-4f32-997a-a821ecf5e85b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3404","original_object":"UniProtKB:Q9NPC1"}
{"id":"086ce1e7-ba56-42a8-b214-de47118c90c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93348","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:e96c9b2c-03e4-4956-be8a-e83eefe69358","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:495","original_object":"UniProtKB:P25100"}
{"id":"8170a04a-2f28-4da3-b24b-6e71159fd063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2576","predicate":"biolink:affects","object":"NCBIGene:25736","sources":[{"id":"urn:uuid:bc76b0eb-c63f-4b1e-a494-ad5090f1b5d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2576","original_object":"UniProtKB:P15387"}
{"id":"c19ebed4-eb8e-4cc0-993b-c3c9cea31cf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86296048","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:73091a4d-20c5-4889-a124-a0de4872a953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11890","original_object":"UniProtKB:P34972"}
{"id":"c9ad9e57-8fcb-4f6f-9b58-f82194acae62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24881008","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:4c83bef4-6552-4870-a0b5-f30b68884214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4110","original_object":"UniProtKB:Q8NER1"}
{"id":"48842c7f-6f63-423d-a415-e6194d6382c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030518","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:f6ac47f6-f81b-4d23-8fa1-59542e18a41f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10420","original_object":"UniProtKB:Q08345"}
{"id":"4babf297-a692-4284-b562-23d99e264d25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:2044","sources":[{"id":"urn:uuid:114df853-e9a1-4c55-b8c9-586c8fc6d76d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:P54756"}
{"id":"e4ad9f58-214c-4ba7-a101-e712b5603359","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:f4e67d3d-047d-4a2e-b761-7303297c536a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P18825"}
{"id":"ad99e874-9ea7-4eed-871b-afbef8ae0bd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135565610","predicate":"biolink:affects","object":"NCBIGene:4352","sources":[{"id":"urn:uuid:9ec5ba34-4a05-4402-9917-a7ba3228b836","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10657","original_object":"UniProtKB:P40238"}
{"id":"afe7f2b4-c8f4-4eac-b3fe-41a305919fc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44569287","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:a266a714-6796-41f2-aa83-69318430ccce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3079","original_object":"UniProtKB:Q02769"}
{"id":"f2f309f1-8925-498a-bc1d-0b8efde315e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:61cba20d-4e2a-42d7-9f0c-0b842eb8b383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P0DMS8"}
{"id":"a8fb81a9-f557-404c-b0c8-b67afa8aa5e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:311","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:b6629776-121a-4d70-a59f-e41a0607c9a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:311","original_object":"UniProtKB:P08173"}
{"id":"a0efe30b-8c36-4c22-9985-a47938117808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104766","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:f21f4b22-67c4-44c1-9c20-5819a7ecfeb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1365","original_object":"UniProtKB:P23385"}
{"id":"87df0028-ecd1-4766-a931-bdbba6486cb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817422","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:ee09761c-7b20-4fcd-ac35-ef0991fe4ced","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1549","original_object":"UniProtKB:Q63634"}
{"id":"cbb291e7-281c-494b-9534-23c8051bc382","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91368","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:287d0cc2-3443-459b-b988-3cbaae93adc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5693","original_object":"UniProtKB:P17252"}
{"id":"8c84b99b-f9e7-472f-b3be-b86865e9f1b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185746","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:cc849345-817a-4659-8c4d-baa3475f8c79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7058","original_object":"UniProtKB:Q9UBN7"}
{"id":"42373c45-fb07-417f-94ab-12465012eb5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6917952","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:89aec4f8-37f5-445a-8413-7a78f7f6d23c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2223","original_object":"UniProtKB:P30518"}
{"id":"524e53b3-99d0-4450-9097-f49a1619e572","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76591","predicate":"biolink:affects","object":"NCBIGene:10062","sources":[{"id":"urn:uuid:0551cdb9-70ab-433f-a8a5-79ab1cf779b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2752","original_object":"UniProtKB:Q13133"}
{"id":"e82611f9-ffde-460d-a7d8-79cdf9a7dd28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:338567","sources":[{"id":"urn:uuid:7cb99296-bf2b-4479-aaa2-51bb780522f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:Q7Z418"}
{"id":"e26d86de-68f4-431c-850f-32f9e8d64246","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801483","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:55aaaad9-08ae-417b-b74c-d3e672049043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10547","original_object":"UniProtKB:P50750"}
{"id":"7331f857-187d-4c97-b051-6e76619f645e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030522","predicate":"biolink:affects","object":"NCBIGene:3294","sources":[{"id":"urn:uuid:3eeff482-8eb3-4e9f-8dae-0bc87ae0f140","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10438","original_object":"UniProtKB:P37059"}
{"id":"2be251df-abfa-472e-9447-9a2c87d4caff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947031","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:d1eb4f7a-aabd-4702-a963-2bb2ce5ed262","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2999","original_object":"UniProtKB:P51639"}
{"id":"6a9b5004-2e97-4556-aaf0-9064bfd94440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30768","predicate":"biolink:affects","object":"NCBIGene:2867","sources":[{"id":"urn:uuid:bed676cf-bbff-44b3-bf3f-cb625a2321c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1062","original_object":"UniProtKB:O15552"}
{"id":"5dfd4dfe-a8ad-4bcb-971b-1632833e6369","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2161","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:3bce9c14-5210-4598-9cea-10727c2a7161","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2161","original_object":"UniProtKB:Q9UKP6"}
{"id":"d585ed57-b581-4002-a58e-0c1bcaaf33a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:4e5c2ccf-496c-48a8-9fd2-be754fb92f37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:Q9Z2J6"}
{"id":"b7cb1d40-cfa9-43fe-884a-4b858f7c07bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:12WJ62D047","predicate":"biolink:affects","object":"NCBIGene:116085","sources":[{"id":"urn:uuid:7e793439-2864-4aec-9168-b700b58a2944","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9327","original_object":"UniProtKB:Q96S37"}
{"id":"cf61589f-9cfd-4aed-a343-868cd2e1cf37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57330144","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:63ea8bf0-8a1f-4513-850b-7da407ba2f3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8034","original_object":"UniProtKB:P49798"}
{"id":"8994cbdf-e92a-46e3-8983-c44c14b0f3f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5841","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:dbfe90a4-4f6c-4e83-bcb7-3a59f967f4d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5841","original_object":"UniProtKB:P21462"}
{"id":"48c028dd-d932-40ed-93cb-9acf5b55687c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755227","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:988de828-e4df-4eee-a6ad-8c99d85d6404","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6580","original_object":"UniProtKB:Q9HBW0"}
{"id":"41de901a-5b08-47b8-bce1-5df9c475f156","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947015","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:a9cb846a-959d-4056-b6f2-8f50c162d3ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3204","original_object":"UniProtKB:Q62967"}
{"id":"b639c276-dfcc-454c-a45f-d8aea622f1c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q56UE7E40Y","predicate":"biolink:affects","object":"NCBIGene:101","sources":[{"id":"urn:uuid:5b1e2597-b2f7-4f24-a162-f3db3a7ca44c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8679","original_object":"UniProtKB:P78325"}
{"id":"ca422d17-4f77-4bd3-8a2e-2aefd307369b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132369","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:cd5940a4-a6cf-4260-9681-dd09c6fdb2cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2280","original_object":"UniProtKB:P32241"}
{"id":"b4e301b0-f5bf-4fa8-b212-6164544f8791","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:193137","predicate":"biolink:affects","object":"NCBIGene:331","sources":[{"id":"urn:uuid:0eee2847-0a76-4b1a-af6f-c84a08587831","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7912","original_object":"UniProtKB:P98170"}
{"id":"599452ad-9e47-4403-bf16-c28b2fc4dac1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75253","predicate":"biolink:affects","object":"NCBIGene:5297","sources":[{"id":"urn:uuid:d4cbcf76-eb05-4e44-a95c-9e675bba72e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9201","original_object":"UniProtKB:P42356"}
{"id":"91f6b08d-5979-4395-bf21-91d86a74c7b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131490","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:2a1fb6c2-f9ab-4ad7-a848-d47855608fce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8018","original_object":"UniProtKB:Q00535"}
{"id":"7af6f4ed-e10f-4d7e-a14d-7d5694b683e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6456","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:67b25bb9-a544-41c5-a74f-ede379c26485","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2623","original_object":"UniProtKB:P15390"}
{"id":"4b44d54c-a046-4c46-8239-fdfb26ef6406","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92890","predicate":"biolink:affects","object":"NCBIGene:2185","sources":[{"id":"urn:uuid:122cff38-cb2f-4a66-ad18-375877cc658d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5923","original_object":"UniProtKB:Q14289"}
{"id":"18cd3570-5ceb-448b-81f3-1763c2435992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16755","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:a079ab4c-d0e4-4f74-be86-01a8d4cb53e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:608","original_object":"UniProtKB:Q8TDU6"}
{"id":"65f0f617-275c-4d2d-bcd4-e9c3916c2307","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2M8K8ZJJ5U","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:dd5a905e-582d-4023-99a1-b51f2f29c085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4287","original_object":"UniProtKB:P31644"}
{"id":"bcb353bd-dc25-408f-9a66-8325be5237db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817471","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:4e2f42e6-532a-4c0c-b657-c71023ee2cc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4449","original_object":"UniProtKB:P49190"}
{"id":"a78c4820-6921-4a67-b3df-04c363208882","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71533431","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:8a11ae0e-167c-45b0-87fe-9c6a74ed65a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7775","original_object":"UniProtKB:P48039"}
{"id":"a7898523-9989-4645-acc8-bba6cec019f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17183","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:0aa67ca3-06e1-4ec2-bbda-4c883c268a80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11563","original_object":"UniProtKB:Q9UGC6"}
{"id":"d3a564cd-12ba-4e8d-a762-424162c16fbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:7660553e-5c01-4b30-b0d6-0fbcd4d7ac6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P08913"}
{"id":"73530f1d-956a-4cb9-ae7d-639fded0a277","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18258","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:e73843ea-3f50-4756-85fa-1f762df21d66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2634","original_object":"UniProtKB:P10828"}
{"id":"5cc29fc8-ac95-430f-ba7d-d2a2c7fd49a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122552662","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:c8629ff3-7801-43ec-96fe-b3db583e2f5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10020","original_object":"UniProtKB:Q02127"}
{"id":"eef39247-00e6-4c08-95cd-59b8dd89c140","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6255","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:bb27d37e-c135-4a61-a361-6fc7baeda1e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6255","original_object":"UniProtKB:P31421"}
{"id":"669300f3-a2a2-4752-a12f-02e004399d25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137628688","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:7b64db33-4322-4bd2-8727-98cf85245294","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12986","original_object":"UniProtKB:P00533"}
{"id":"b63b290a-70d6-45ec-994b-1db5bd5fdac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:3029c611-08a0-4e32-a451-01bcf2f5274f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:O15379"}
{"id":"2a31c5e7-8af4-4b87-a913-18bde7ad83d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L08J2O299M","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:3ca84a77-05fa-415f-963f-676db5bbb44d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7794","original_object":"UniProtKB:P42336"}
{"id":"6be08d59-c27e-4570-8886-18a0c9ad802b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755212","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:c623d10f-ff7e-4c9f-a502-8574645f3d43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6366","original_object":"UniProtKB:P41594"}
{"id":"0a32e55f-6ed2-4df1-8781-00c5a34dbc2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:4a2fca03-9ccc-490e-a992-06043f6ccd5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P34995"}
{"id":"eb68df49-7c59-4b43-9396-0729731c7327","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12992","predicate":"biolink:affects","object":"NCBIGene:1493","sources":[{"id":"urn:uuid:09710f6f-4e4c-46a4-91b6-0824f1cc7108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12992","original_object":"UniProtKB:P16410"}
{"id":"aa1548c3-7810-4b10-b0f7-5c604d4fda93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659803","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:e4ff855e-cae3-4b26-98f4-87771758eca5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6338","original_object":"UniProtKB:P23385"}
{"id":"62953798-6ecb-4e51-91cd-d0d56ace4df4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50729","predicate":"biolink:affects","object":"NCBIGene:7153","sources":[{"id":"urn:uuid:17a08fec-ec59-4960-82e4-b7f70f966612","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7242","original_object":"UniProtKB:P11388"}
{"id":"418b5fa9-ba12-4762-b69f-80a6105791ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109731","predicate":"biolink:affects","object":"NCBIGene:2161","sources":[{"id":"urn:uuid:a313adb7-6cfe-45bd-a420-2f1a03601120","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6553","original_object":"UniProtKB:P00748"}
{"id":"20b7c0c6-cadd-4370-8147-f833f2dc64ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:68304fed-bd04-43f7-9a3d-a6b692a32646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P42681"}
{"id":"6f745b85-a823-466b-b09d-201755ad0634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53384864","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:b640a50a-ab7e-423d-9ce5-ebd2aff81701","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6411","original_object":"UniProtKB:P31424"}
{"id":"75fced7d-f73b-416b-8f71-f207529af998","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827346","predicate":"biolink:affects","object":"UniProtKB:Q61618","sources":[{"id":"urn:uuid:d328ab32-418f-4935-851d-fddef29f7740","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5622","original_object":"UniProtKB:Q61618"}
{"id":"eccf26f6-df1b-488c-bc5e-0687221eeb04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24863112","predicate":"biolink:affects","object":"NCBIGene:140609","sources":[{"id":"urn:uuid:a86f0dc7-d2da-4bcb-93d4-14cffec1be71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8205","original_object":"UniProtKB:Q8TDX7"}
{"id":"c9dddfb8-076b-4317-b0d4-3d41299e1c02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:213050","predicate":"biolink:affects","object":"NCBIGene:1215","sources":[{"id":"urn:uuid:35579d80-de4f-480e-90a5-a18f14cd8028","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6503","original_object":"UniProtKB:P23946"}
{"id":"6f2fe5a5-b4d5-4229-8685-9c747036653b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:6262","sources":[{"id":"urn:uuid:b29a8889-379f-42bc-b2eb-b4f84ff779f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q92736"}
{"id":"a66d267d-8238-4fbb-92b6-f5d90276f66a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135578","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:d41f1d83-adcf-44e7-9954-a0409ae3830c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1917","original_object":"UniProtKB:P43115"}
{"id":"6b5841cf-653d-47ec-aab5-dd3854cf8d93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5812","predicate":"biolink:affects","object":"NCBIGene:319239","sources":[{"id":"urn:uuid:771f517d-2145-4080-ae2d-2dc7bc84093f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5812","original_object":"UniProtKB:Q8BZP8"}
{"id":"f461aaf4-bb2b-4768-9ca8-0c39ca444146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1697","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:8db464ef-fca1-47ad-8693-06d85c746860","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1697","original_object":"UniProtKB:O43614"}
{"id":"f7b37f22-99de-4a2f-bf2d-d101e55a6969","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:098089a5-8263-4fc8-8350-573d2d49becc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q9UBN7"}
{"id":"7aa12050-9dcc-4a0e-915f-34e8b81d680a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46944265","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:ac08c1b6-0fb3-43bd-9202-02c8da347396","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7853","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"1d57e8ed-7fba-47c6-a56c-9d14cf7ea066","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92110","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:d30b3253-3818-4a2f-8b5d-253cb59a266f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8594","original_object":"UniProtKB:P08482"}
{"id":"17e29289-38d4-4a9c-bdfe-28a1c8528fdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54SQ9B412I","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:2f2267c7-423f-465c-aa8d-50df5bbd8ae1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6439","original_object":"UniProtKB:P41594"}
{"id":"90247d2c-00b3-4061-ad75-e5382606cc24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817391","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:e11456ea-5b89-40a0-b6b4-b440fb1e6f15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1137","original_object":"UniProtKB:P43220"}
{"id":"84fc9496-f3f1-4a88-ae58-a654df9bc4d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9937534","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:4c64bc57-e053-47c8-b49e-30164d8d0669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:621","original_object":"UniProtKB:P30550"}
{"id":"381491d1-3c62-4e6e-a6f6-77787e189482","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47520","predicate":"biolink:affects","object":"NCBIGene:1583","sources":[{"id":"urn:uuid:6de7bc5d-1692-488e-b420-1884fa21105b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8871","original_object":"UniProtKB:P05108"}
{"id":"1b04b623-02d7-43e9-ae66-986252ad6543","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156735500","predicate":"biolink:affects","object":"NCBIGene:9293","sources":[{"id":"urn:uuid:ec4eabae-088b-43b8-80f9-ff96154e4041","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13909","original_object":"UniProtKB:Q9Y2T5"}
{"id":"35d77913-50a1-4243-a65a-eeca58823954","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29009","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:49dbddcb-0bdb-49c0-8c8a-1642dd768068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1242","original_object":"UniProtKB:Q91ZY2"}
{"id":"3b24d622-3dc2-4255-bf3b-271007acf5c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311382","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:c62927f2-e525-48ab-9122-2a45a6ccdb38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8183","original_object":"UniProtKB:P11362"}
{"id":"c9812973-3777-43f6-aff8-5ce8b8cc1085","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135494270","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:1f6b91d3-d4db-4601-96e9-36619beb7909","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:376","original_object":"UniProtKB:P30542"}
{"id":"bf70c8c5-5fb8-4e60-8938-06c20f912229","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166101565","predicate":"biolink:affects","object":"NCBIGene:55811","sources":[{"id":"urn:uuid:484e039d-9fd9-4eaa-8ab6-9041d82ca13b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12309","original_object":"UniProtKB:Q96PN6"}
{"id":"18634319-a0bb-4b32-8b0e-b0987b60e5f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42491","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:862f294d-afcc-4b45-ac83-ee2681606d53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:409","original_object":"UniProtKB:P0DMS8"}
{"id":"4f3b3adf-8678-448b-a417-0e264183c242","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75261","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:4a013efa-7497-4446-b206-354525ca1185","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2646","original_object":"UniProtKB:P10826"}
{"id":"419c3df9-608e-4233-8f18-b55f36a88f33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231409","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:56ba631d-31c7-49c0-be8d-a71d5661ae3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9192","original_object":"UniProtKB:P41145"}
{"id":"660a78ea-1602-452d-8395-5323652feb69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2158","predicate":"biolink:affects","object":"NCBIGene:217369","sources":[{"id":"urn:uuid:0cb28307-c713-4088-a125-562c14d09e52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2158","original_object":"UniProtKB:Q8VIH9"}
{"id":"a6163e75-1a0a-4429-bb3a-d5b955239ccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24802717","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:67334190-2d36-40d3-a5a6-3f1a9c78091a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11625","original_object":"UniProtKB:Q9Y233"}
{"id":"38526747-dc77-49a4-a4ce-6f2ffe9e6e73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:6f32647c-8f74-463c-a0a3-e824ce09a9d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:Q13153"}
{"id":"67b90db2-208a-4959-a937-5efb6e2f2bfb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121373418","predicate":"biolink:affects","object":"NCBIGene:1387","sources":[{"id":"urn:uuid:ebd8be7e-d593-41f3-b6ee-923ddaf077c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13247","original_object":"UniProtKB:Q92793"}
{"id":"6a3cec6a-c800-4f78-be26-cd311037567f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3793","predicate":"biolink:affects","object":"NCBIGene:3973","sources":[{"id":"urn:uuid:35cd046e-69a9-4a79-a5ad-1772cc719fd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3793","original_object":"UniProtKB:P22888"}
{"id":"04d87d74-104e-406a-bab8-0c301f5f88ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135361","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:181849d5-a709-42e8-b5f0-8802c6541f55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:317","original_object":"UniProtKB:P08172"}
{"id":"d8915c4d-441e-41f1-b23c-59cc1affc67d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4Q52C550XK","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:54614084-809f-4094-b186-2f0dba1d4387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6777","original_object":"UniProtKB:P11836"}
{"id":"f5cada66-2640-48f6-abc1-7b3526cb997c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6950","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:02a3b114-2a9f-4f35-82a2-2857834df250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7241","original_object":"UniProtKB:P28223"}
{"id":"b5dc1c24-f8ca-4d49-b221-3c1767d40728","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3867","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:4f1d6995-8b0a-49aa-8783-52c771c5439d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3867","original_object":"UniProtKB:P37288"}
{"id":"0402f3c5-2d42-46de-861a-a4e65230e69d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80249","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:ace83232-3ba7-4bae-abcb-e100fffbbc2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2020","original_object":"UniProtKB:P30938"}
{"id":"3d659ec5-9e29-4136-b043-7475b881fccc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16119086","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:6cd7bb32-dcd1-4977-9f79-17d46b2024c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9058","original_object":"UniProtKB:Q9Y5N1"}
{"id":"54719934-d417-4294-b2c8-57d5d5151dbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3215","predicate":"biolink:affects","object":"NCBIGene:56543","sources":[{"id":"urn:uuid:5d634fdd-a4bc-43ab-a0c3-bb160252b7a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2397","original_object":"UniProtKB:Q9Z0V1"}
{"id":"48e7d4e3-6af9-4f27-8089-832e81c8a18f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7567","predicate":"biolink:affects","object":"NCBIGene:81574","sources":[{"id":"urn:uuid:b5942727-7c53-4751-8843-befff182f3c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7567","original_object":"UniProtKB:P04774"}
{"id":"f38aae03-caba-4a5d-9070-8e7304a6cc05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P76B05O5V6","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:8c81618b-220d-4073-9fb4-eaf1496ffef2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5586","original_object":"UniProtKB:P30968"}
{"id":"8c7a13b2-0626-4d26-9492-11507ab60c29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232381","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:eea441e3-2a9f-4391-9de4-ce09b8da4bac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9355","original_object":"UniProtKB:P23443"}
{"id":"135a92d0-f47f-4e69-ad3e-5fff790903c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34799","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:2b94b130-1095-4a11-bd49-75b435eea308","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4226","original_object":"UniProtKB:P47869"}
{"id":"661dcba3-b28b-479f-a210-cc8f9aeb897a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11248240","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:7419de95-dba5-4066-ab9a-882cd37752fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5601","original_object":"UniProtKB:P25099"}
{"id":"6ce42c72-ecc3-4b02-a32f-179b7999dfd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:874OEY3JEJ","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:fa680cfa-b912-4ff5-9b8e-8652325da043","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10375","original_object":"UniProtKB:P34998"}
{"id":"9da5cb9b-7b0b-4600-8dfb-a2254ecabc52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1513","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:e48e9dbd-0803-4b01-9b4b-5414d1065619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1513","original_object":"UniProtKB:Q15761"}
{"id":"87117b8d-3bd4-4df8-b44d-0162441e4f09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71624791","predicate":"biolink:affects","object":"NCBIGene:780","sources":[{"id":"urn:uuid:caad962b-669e-4b1c-b084-1b89e850c524","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8164","original_object":"UniProtKB:Q08345"}
{"id":"352fd095-0838-4b12-8cd8-12e8b20ecdc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DO9M06BFRJ","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:c3d4ec3d-d0aa-4801-8831-4fefc5ce0558","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:979","original_object":"UniProtKB:P30729"}
{"id":"a5e5b4df-4d7a-4879-bae9-9d98e4b67494","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6780","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:6eec0f2d-813f-495a-b05b-c135e64c4e64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7227","original_object":"UniProtKB:P21728"}
{"id":"5061f44d-1edc-4283-b7ec-0d51d5faf1bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154730265","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:7e646c90-881a-46f8-88c8-22c3f7482577","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11849","original_object":"UniProtKB:Q8NHX9"}
{"id":"39642d3b-ed46-4463-98a6-3b89fe961560","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13946","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:722faa52-d7be-41db-8f0c-84f68eb227e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13946","original_object":"UniProtKB:Q9Y5X5"}
{"id":"391f6cdf-04b0-4104-8005-41e87664d4d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3596","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:08375416-625b-46b6-a230-17848c87272f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3596","original_object":"UniProtKB:Q62805"}
{"id":"b87c7d89-c003-4b49-8225-7386182be1f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164938183","predicate":"biolink:affects","object":"NCBIGene:23043","sources":[{"id":"urn:uuid:6dd810c9-12d1-4e46-84d4-16b9b1af3d06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13279","original_object":"UniProtKB:Q9UKE5"}
{"id":"7b7a1ba7-4df8-4e35-b1c2-56df723ac64d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71580330","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:d3ff7547-9710-4e05-8731-26db2bcc532a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6420","original_object":"UniProtKB:P41594"}
{"id":"8a3913eb-8e0a-49b4-ba2a-c7da7f03fcdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7737","predicate":"biolink:affects","object":"NCBIGene:3736","sources":[{"id":"urn:uuid:886139c5-5fd3-4d09-bc73-a5dfc3de7a33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7737","original_object":"UniProtKB:Q09470"}
{"id":"c354df81-b1d8-4d41-b717-51b51a7bf404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16978","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:ac82633f-1d62-425d-9ff7-c0a28d105d33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3354","original_object":"UniProtKB:Q6NS65"}
{"id":"358b794d-2181-4d15-a315-69e33a33a26f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:4058","sources":[{"id":"urn:uuid:928d8f1c-fffe-4701-9bb8-c4943bad798a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:P29376"}
{"id":"6a6d06ec-d47d-438a-83b0-1a1f5c4a9245","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:774","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:03cf3b99-f907-4469-98d4-0c8d8bd72046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:774","original_object":"UniProtKB:P41597"}
{"id":"c0038f01-380a-47b2-8b76-fbc0cdbcff67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:S4L4MM20B6","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:5a130a8d-e504-458d-ba49-523f8cd62772","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10516","original_object":"UniProtKB:Q15910"}
{"id":"002f7211-d599-4ff5-937a-5e2ecc77f769","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6180","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:614d0278-950e-40d8-b484-76acea2abe37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6180","original_object":"UniProtKB:P30550"}
{"id":"6daacc4e-0bd0-481f-b0d0-b0b0d4591c1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42628843","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:56feeb9b-4815-40b2-a5fa-02b30635ae4a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9815","original_object":"UniProtKB:P04049"}
{"id":"8d0e33e8-99a1-4e8c-9127-003067c1527a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118866105","predicate":"biolink:affects","object":"NCBIGene:23821","sources":[{"id":"urn:uuid:16b365eb-28b4-4f6a-83fe-302c018c9bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10520","original_object":"UniProtKB:P56818"}
{"id":"10687516-7ba8-4b64-bcdb-9ae5fbc28943","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:721809WQCP","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:a2c7e6c4-ed1e-459f-99cb-ad1610191b95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5263","original_object":"UniProtKB:Q9P1W9"}
{"id":"2a038d1c-8d32-480f-bba9-30696dab4935","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17757220","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:c78e72bb-ad34-461f-8eae-ae4c51259c39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6982","original_object":"UniProtKB:Q9EQ31"}
{"id":"643a35fa-9711-4fea-9faf-d87e946c4a36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50902958","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:b5c23145-5bf7-442a-8683-753cf782ee32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:6262","original_object":"UniProtKB:O88704"}
{"id":"2af5f821-35f5-43fe-b99a-7edd377d6e50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67448186","predicate":"biolink:affects","object":"NCBIGene:55872","sources":[{"id":"urn:uuid:775c07e4-1a52-4412-8e8c-d7b037b5becb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7813","original_object":"UniProtKB:Q96KB5"}
{"id":"8da78db3-21f9-4533-b985-01a5d1abf87b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31638","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:f86fdec8-da2a-41dd-bbc6-62b8cbf75348","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1015","original_object":"UniProtKB:P03372"}
{"id":"417a0469-348d-4325-88f5-4d85f08007bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11510199","predicate":"biolink:affects","object":"NCBIGene:5300","sources":[{"id":"urn:uuid:28807ca7-cccf-4dc3-81f2-b06463ea5cc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11398","original_object":"UniProtKB:Q13526"}
{"id":"ffd44a14-3084-4bdd-a2ae-abbf90cabc9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:e5e57c21-4647-4c54-b8c5-a78c8fcccbbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P29276"}
{"id":"cb279614-dcf5-4cfa-9b6c-a47847037aeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13293","predicate":"biolink:affects","object":"NCBIGene:8797","sources":[{"id":"urn:uuid:219bd37c-11f1-4eb7-aadb-c0f6b336ac37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13293","original_object":"UniProtKB:O00220"}
{"id":"ef336b83-4284-4a23-8fe7-55aacf2fd533","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2006","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:b23b2511-08f7-4087-abb9-1302cc2d90b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2006","original_object":"UniProtKB:P30872"}
{"id":"cb8a36b4-502d-4016-91c6-b46f43869763","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T61871RKRI","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:54faaf53-21cc-4eb5-84ee-d4af256fad54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5707","original_object":"UniProtKB:P24941"}
{"id":"f991c5ef-99e6-45da-af61-ba8b8c38d915","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:186187","predicate":"biolink:affects","object":"NCBIGene:11770","sources":[{"id":"urn:uuid:8a16f655-62af-4b39-bd85-77b35b7dc19c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6736","original_object":"UniProtKB:P04117"}
{"id":"acb2bbac-9bce-4928-b06e-f5d411c29a38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:81KHI46E5L","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:1cdb1d29-799b-4d70-9855-4af566d7a55c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:81","original_object":"UniProtKB:P08908"}
{"id":"0a1d15b6-e0b8-4d16-9e8b-a65f55161b1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4009","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:2f3575f1-79d6-4118-aea5-e33a81c4a66d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4009","original_object":"UniProtKB:P32297"}
{"id":"3d0c882d-70a0-4e99-aaa8-e89ec5c9d0b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:0022f8d7-22c3-4d82-bd04-5dfb74c75183","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:P07949"}
{"id":"034c2f8c-1a05-47e6-8e1e-eef71809c54e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2686","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:6fbebc90-ee03-45ca-a61d-17db76f88fe6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7202","original_object":"UniProtKB:Q14432"}
{"id":"54229b8a-7385-46f4-8a65-0a32552f472e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146417","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:ee40a1f1-ae8d-4b82-8ab5-c308f6b7ef80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1839","original_object":"UniProtKB:P25105"}
{"id":"9561fd59-a8bd-431c-9470-cfadb849849d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TXG28R7G4Y","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:1f49577d-f949-4e22-950e-6dc7fe1fd488","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:496","original_object":"UniProtKB:P35368"}
{"id":"f5a70eef-717b-4b09-9ad8-22ef02b74dcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121918","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:0411b78b-29c9-42d5-bcf4-3e10e9b7dfe3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4239","original_object":"UniProtKB:Q13224"}
{"id":"3e532f3a-e13a-43ee-b7d0-b3554a8b7cba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4324257","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:832e0427-a2b9-4cad-a929-419988602c24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4080","original_object":"UniProtKB:Q05586"}
{"id":"b9e826ff-edad-4274-b463-6985a4536f4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93369","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:306258ed-57ed-4677-8409-9f1538db6f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:85","original_object":"UniProtKB:P28221"}
{"id":"19414435-8522-483f-87ae-22e2f5324f54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C6RWP0N0L2","predicate":"biolink:affects","object":"NCBIGene:1613","sources":[{"id":"urn:uuid:50c9576f-9b99-4bde-8b67-36d2805f4102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8126","original_object":"UniProtKB:O43293"}
{"id":"942d4915-15d3-45d8-8ce4-5c77e32e2f5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287855","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:69b12e61-1fc3-491c-8801-4a5113e5f65b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6024","original_object":"UniProtKB:P42336"}
{"id":"dec47462-9c80-42ce-ad30-f0859dcc1798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46906163","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:ea52bd34-d4f1-4943-97bd-e6f0b21d8c1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3024","original_object":"UniProtKB:P04035"}
{"id":"9cffdbca-8b6c-43f9-994c-70969ba28df4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2580","predicate":"biolink:affects","object":"NCBIGene:16506","sources":[{"id":"urn:uuid:7da8c7db-0ff4-4b3d-a34c-2bbaefda1893","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2580","original_object":"UniProtKB:Q03719"}
{"id":"297bf7f6-f780-485a-9c0a-9f8e2877114e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13573","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:568fc5f3-cbee-480a-9d62-b92fb523aee2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13573","original_object":"UniProtKB:P0DTD8"}
{"id":"0accdb62-df94-486d-93b1-76c9a1e8c602","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6950","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:bba59fdb-3488-4060-95ba-8f3cedf1430d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7241","original_object":"UniProtKB:P18825"}
{"id":"281f0375-5575-428d-8ba8-ffc539bcd787","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:582124","predicate":"biolink:affects","object":"NCBIGene:9517","sources":[{"id":"urn:uuid:12105ab0-bd8d-4934-b918-3bd885195f01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6664","original_object":"UniProtKB:O15270"}
{"id":"3ffc834a-92f3-4eff-8555-1a5e5723892a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:dad9346f-9f1f-44e9-90cc-2c913fdd1add","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:O88703"}
{"id":"cdac2a8b-209a-4ccb-8179-a71d6f221386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71219","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:74de01ef-ab3c-4685-b7d7-0649d61b0078","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5698","original_object":"UniProtKB:P17948"}
{"id":"bc9ff696-7bfd-4736-91fd-7385546c627e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"UniProtKB:P25102","sources":[{"id":"urn:uuid:64e17766-f200-4eb8-bad9-59a54d8b98f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:P25102"}
{"id":"6487ece2-ebcb-4beb-9de3-48e37d118fda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LDJ89SS0YG","predicate":"biolink:affects","object":"NCBIGene:916","sources":[{"id":"urn:uuid:18e628e0-864a-4abd-ae43-cf46b08c4d1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"antibody_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12298","original_object":"UniProtKB:P07766"}
{"id":"27fa5042-a00f-47aa-afc6-96525fdbeb23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6485181","predicate":"biolink:affects","object":"NCBIGene:353250","sources":[{"id":"urn:uuid:a2af3b3e-20b3-431a-9a38-c8e57f7df45a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1591","original_object":"UniProtKB:Q80Z39"}
{"id":"6098946b-6a9b-420e-adf9-d8a8b361598d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:aca4f191-9a4d-4167-a9ef-1658a5d44ac2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1641","original_object":"UniProtKB:P33534"}
{"id":"22d487e0-004b-442a-9c7a-0c617e68e7c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6D848RA61B","predicate":"biolink:affects","object":"NCBIGene:25235","sources":[{"id":"urn:uuid:b44f4040-2e41-4ea0-bd9d-087cd4d9b404","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12013","original_object":"UniProtKB:P16310"}
{"id":"60a28fab-5540-4f09-a033-c225c68e9570","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L1V1K2M4V","predicate":"biolink:affects","object":"NCBIGene:25605","sources":[{"id":"urn:uuid:02bae6a5-cd2c-4aa8-b525-52b69190f1e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4461","original_object":"UniProtKB:P56719"}
{"id":"cda3d4b4-5c68-4b21-928d-184f883248dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92537","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:63866262-d473-4a0a-8391-3f7648c79976","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:28","original_object":"UniProtKB:P41595"}
{"id":"0cdcf5a8-9ac7-41c3-9673-674925f84514","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4778","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:fdd3e724-e609-4adf-b4a5-a710a54c3362","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11209","original_object":"UniProtKB:Q9NQS5"}
{"id":"a6a096e1-a028-4715-aaa7-2373aa9ca180","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10682","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:17c36bfc-69b8-4ee0-906a-52467df189c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10682","original_object":"UniProtKB:P40763"}
{"id":"0a0d274a-9991-4989-9a07-344e7b472b29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53233900","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:4e8ce3c4-fa0d-473c-959b-b480eb6d8b5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6213","original_object":"UniProtKB:P23385"}
{"id":"99b9e822-7fed-4a7b-9cc7-17ea5cba0f83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90170031","predicate":"biolink:affects","object":"NCBIGene:5650","sources":[{"id":"urn:uuid:dbc413de-2954-4686-874f-b6d2cd3de8df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8483","original_object":"UniProtKB:P49862"}
{"id":"afa8f9b8-c0ee-4ff6-9eef-18de21ac5224","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11824289","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:3dee4a47-2c96-4728-b61a-e61c545cabcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4094","original_object":"UniProtKB:P31644"}
{"id":"9f81d906-540c-4cb4-b7da-5cfe7d8d4226","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53316847","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:251b3a24-9b47-4902-b293-94d212ff6b7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6334","original_object":"UniProtKB:Q13255"}
{"id":"45ca587e-0bb0-421d-a080-5254f291a6af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17364","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:c34f1c6e-7685-4960-95f9-dae54cd7b68a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6511","original_object":"UniProtKB:Q12879"}
{"id":"ce864c97-36b0-4011-a17e-176a6dc2bd79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9797370","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:6dfa9f88-ec3e-4b63-9666-4c1c9b7c6ff3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6020","original_object":"UniProtKB:P09619"}
{"id":"1bd82678-6085-462f-8ae0-27fef62f6fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4052597","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:25a9d5df-20d8-48a0-9d2f-11ff24e79ff3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6229","original_object":"UniProtKB:Q14833"}
{"id":"2df68aa3-55c0-4223-a521-c99d2e8fa8c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:28PGH5X4OQ","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:a427e6c9-708e-4a69-9d3d-bda212e334e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8432","original_object":"UniProtKB:P34969"}
{"id":"67cc8429-169a-4313-a121-4f15e3cdbea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134716","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:24c68b15-71c1-4af5-bf00-3427e5ac31d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7672","original_object":"UniProtKB:P14416"}
{"id":"ae29f8bc-f2d6-427a-a5b6-48233049db72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102129367","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:fca31c05-2fc5-41a2-ac1b-8fa748259a92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12469","original_object":"UniProtKB:P59540"}
{"id":"3eaaa250-91a2-488e-b303-bb8f15320ddb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KF50235Q04","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:7ac93e4e-9c3c-4856-acfb-a66f3b188f15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7346","original_object":"UniProtKB:Q9Y5N1"}
{"id":"18b210d9-08b1-4670-b66a-351981d365d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92749","predicate":"biolink:affects","object":"NCBIGene:2872","sources":[{"id":"urn:uuid:b9a8e36e-f136-4e77-968b-b8154cd0fdd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6010","original_object":"UniProtKB:Q9HBH9"}
{"id":"531ad998-54b9-4da0-8095-90dc1771eb06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18357","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:c39877db-d2b3-46de-94a1-8a9996fa46d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:505","original_object":"UniProtKB:P35348"}
{"id":"ad651041-a52a-4900-a7f3-b2c248bb12b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:935415","predicate":"biolink:affects","object":"NCBIGene:10765","sources":[{"id":"urn:uuid:a6cd6ab0-12c0-4745-9929-3d14e0c89f8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7026","original_object":"UniProtKB:Q9UGL1"}
{"id":"585731ce-1703-494f-8f38-fd2ea2b9ce22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:56S17Z6X9M","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:457fd071-8a5c-416f-9fd7-f6621d1b63b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1185","original_object":"UniProtKB:P30968"}
{"id":"da2da3ac-e953-4273-a5a4-9f206927818d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5Q7I1WL2UY","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:2c6cd099-1176-40b3-8209-16325d217667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:20","original_object":"UniProtKB:P08908"}
{"id":"6291c786-07f3-43cb-abc9-8cb36a0c4f18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9887077","predicate":"biolink:affects","object":"NCBIGene:29256","sources":[{"id":"urn:uuid:8d918bfc-275a-487b-8e75-72a34ae7eb11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8868","original_object":"UniProtKB:P35370"}
{"id":"efdc866d-8c0b-420e-899a-6dd72df40b2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41922","predicate":"biolink:affects","object":"NCBIGene:2103","sources":[{"id":"urn:uuid:800fb071-1fc7-460f-8dd3-b9bb9eff0551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2801","original_object":"UniProtKB:O95718"}
{"id":"3d6182aa-9e41-470f-a558-073f9b2da243","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:a7bc7e49-d2e0-45c8-87ca-369f0e9a5454","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:P18089"}
{"id":"313cd4e7-e920-48a1-9281-cd8e79f0de1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0W13ZI072Q","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:09ea1dc9-ab9b-452d-ae74-90b1ab556c3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1664","original_object":"UniProtKB:P41145"}
{"id":"cc2a5426-c295-4790-bb52-2ec2350e6d16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139415233","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:7f02d1f6-8cf0-4b36-a039-2486f7b3f0fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12865","original_object":"UniProtKB:P30530"}
{"id":"285d3d60-76a3-4f9a-94c0-0a950a867b9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16181638","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:7b8a9e3a-878c-4f91-b24c-12ce768db35d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4161","original_object":"UniProtKB:Q14957"}
{"id":"49da0641-e6d5-4018-b59a-6718129907a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79615","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:d717b37c-5904-4f49-8b22-fa37d48ec4ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3503","original_object":"UniProtKB:P32239"}
{"id":"14ce52fd-ea01-4178-9dce-588c7d8cff2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231364","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:6f364bb0-277e-4b05-9703-c68e53e11f53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7934","original_object":"UniProtKB:P06493"}
{"id":"c8df707f-d7fa-4613-996d-654717676bf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6474","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:b4c52870-1b69-4dbf-8bd0-5096e1c52cf0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6474","original_object":"UniProtKB:Q13255"}
{"id":"3cd9ea42-dc1c-4aa0-aea0-a8689b74ab15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2898877","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:12be6c35-0f78-4c4b-98d7-3f9fe9d7450c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12257","original_object":"UniProtKB:Q5XXA6"}
{"id":"fa72f786-b1a7-4e74-bc2c-132d85447549","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76016","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:b3908239-d556-4e8e-89f9-1fae709df745","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7351","original_object":"UniProtKB:P50406"}
{"id":"6ebe5833-b43c-4320-b0fa-ce64e4582dd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134846","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:68947d5b-fcfa-4198-917b-3e50a0eb64fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:306","original_object":"UniProtKB:P08173"}
{"id":"a56dbf73-fb26-4429-be2f-3dc5815b8b72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9557","predicate":"biolink:affects","object":"NCBIGene:2208","sources":[{"id":"urn:uuid:67317777-bbbe-4274-ba5c-76d225e7a367","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9557","original_object":"UniProtKB:P06734"}
{"id":"10e5fce6-fb22-4f3c-9926-1a2ace56717a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46852450","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:e46d071a-72e3-47b2-a3c4-f3454bd47b6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9663","original_object":"UniProtKB:Q92769"}
{"id":"c638f158-234e-41f7-abb1-fed124725060","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40303","predicate":"biolink:affects","object":"NCBIGene:15357","sources":[{"id":"urn:uuid:d6d35446-fdb0-4d91-8961-7b7f270cac42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2739","original_object":"UniProtKB:Q01237"}
{"id":"522f9470-a4f4-43d4-9c7d-c74e38baf445","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167671","predicate":"biolink:affects","object":"NCBIGene:8877","sources":[{"id":"urn:uuid:fc20cf60-ba79-47aa-83ac-67fb71413143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10641","original_object":"UniProtKB:Q9NYA1"}
{"id":"542c9185-4692-47cb-9584-4a79bfe6e2e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4470981","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:23a456a8-6247-4729-b036-2129358ed73e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10429","original_object":"UniProtKB:P53779"}
{"id":"543f4ad3-d929-4668-afad-870320be1f76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52670832","predicate":"biolink:affects","object":"NCBIGene:676","sources":[{"id":"urn:uuid:9289be4b-4c4d-4223-acb8-3c00fc07bc2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7524","original_object":"UniProtKB:Q58F21"}
{"id":"8626d1a8-e4a2-48e3-8c53-2b606b5a9143","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92476","predicate":"biolink:affects","object":"NCBIGene:57468","sources":[{"id":"urn:uuid:e608d880-8709-48b9-9827-09a43f0cace7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4665","original_object":"UniProtKB:Q9H2X9"}
{"id":"da234629-fd2b-47bb-ae1b-b6a4ad9b2d7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:0886fa6f-923c-4a3f-86ee-9a60fe4b40c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P30966"}
{"id":"e8a67938-0ff6-4db9-9c2e-cfed78178c37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T5490K8I7S","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:91791316-3ad5-429d-b1b9-693fcf66aecb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5948","original_object":"UniProtKB:P06493"}
{"id":"79a510d9-faf5-4f57-8825-217d0fe1a051","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:343450","sources":[{"id":"urn:uuid:ddd77b69-5ccf-4bd5-b8f5-65b840865d7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q6UVM3"}
{"id":"9e7d02db-3b9a-4222-b0de-d10e8c0f2c16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:b0a8e9bd-9f84-49d6-a477-2a16000b8d89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P41146"}
{"id":"705e2230-7e5e-4eb3-9ce0-4b2ee32214c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9957278","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:fe8d3ab0-a38d-4876-ba6e-7d7201309512","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1179","original_object":"UniProtKB:P30968"}
{"id":"2679e74e-c7c1-40e3-9c3c-dd466c4822db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:5f040590-6d54-4710-a193-9503135e1e9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P34969"}
{"id":"6866006b-6940-478d-aeb5-308189e11406","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:166834","predicate":"biolink:affects","object":"NCBIGene:59272","sources":[{"id":"urn:uuid:5fbab968-4a4c-4d6a-8851-bc542adfe03d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7866","original_object":"UniProtKB:Q9BYF1"}
{"id":"81e5b614-d23f-485e-809f-a9e91c8920a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5739","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:9e3fadf8-0f8e-4204-915d-6cec4e2415d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3884","original_object":"UniProtKB:P30968"}
{"id":"96ec58a3-a9e8-4ea9-b231-936d8e789c89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5294","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:5133bdbb-197d-4c54-ae9b-2de97f1c3177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5294","original_object":"UniProtKB:P42574"}
{"id":"261e01ea-97a3-49c7-9a28-c3f59a4e5ff3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081958","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:5920eb3e-e046-45ec-b04b-af51ef213fdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9845","original_object":"UniProtKB:P35408"}
{"id":"2f7325de-9464-46fc-a73d-d5ac0160e1de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16731","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:16e76be7-a634-4a86-bc93-89e4c0ca4541","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2423","original_object":"UniProtKB:Q8BLA8"}
{"id":"1d3577b8-28d6-4213-a184-8a52fc1d334b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94688","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:58e4182f-e1e2-41d3-8abf-fe4c6db117cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1596","original_object":"UniProtKB:Q8TDS4"}
{"id":"2dbd5b6d-90f0-4ef0-b92f-94d315834541","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817479","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:5a288852-23bc-4ba4-af30-36e5422ac39e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6083","original_object":"UniProtKB:O88626"}
{"id":"6d9217b1-dd2b-4376-a90c-d039495a2c93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1FI3KTC550","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:7a492c4c-50f9-469a-a131-e5180a6fa0da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4327","original_object":"UniProtKB:P34903"}
{"id":"fcb50529-c519-4edd-98fc-a8f0046d235f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:d60bbf0d-5403-4f23-993a-0c45b8473cf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:Q60614"}
{"id":"ffc689a6-8306-43dc-9335-a92a4c488460","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163264127","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:b720560c-bd83-411f-af8f-7748b89849cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12337","original_object":"UniProtKB:P13569"}
{"id":"cc286acc-0792-48ca-a592-6c664ce19458","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71711862","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:6a34876c-fc56-462b-9aff-8fa3c68befe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11023","original_object":"UniProtKB:Q15858"}
{"id":"f73dd306-f84f-437b-af92-31e72b3571f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90863","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:9a4c83f5-da29-4008-a122-5a64cd3b2311","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8199","original_object":"UniProtKB:Q99835"}
{"id":"e0a1a445-54db-460e-a906-f340f970f77e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4967","predicate":"biolink:affects","object":"NCBIGene:3454","sources":[{"id":"urn:uuid:15ddacef-1a42-4ad3-9106-782cdb5022e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4967","original_object":"UniProtKB:P17181"}
{"id":"fedc07c2-da45-493d-8c7d-fc20d1d15331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9486","predicate":"biolink:affects","object":"NCBIGene:6564","sources":[{"id":"urn:uuid:fd1edd6b-3174-422d-9d74-a491cacd0928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9486","original_object":"UniProtKB:P46059"}
{"id":"604a694c-5b1e-4b7b-8a64-e82fdd8e514d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2430","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:e8b4c505-d118-4da7-924d-44bdaf14fe13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2617","original_object":"UniProtKB:P04775"}
{"id":"e41f5d1f-729d-40a7-ab04-46e3ec6e96f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94392","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:bd9df6db-ec71-4e17-9c19-4c862069464d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10019","original_object":"UniProtKB:Q12809"}
{"id":"516b6ed2-d865-4e31-911f-bb22b710ea6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231417","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:5da04358-5c25-443d-9b2c-f908fe04e5d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9259","original_object":"UniProtKB:Q86X55"}
{"id":"07340009-9901-49dd-9a21-99a21100efb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0ZZF1V8G63","predicate":"biolink:affects","object":"NCBIGene:4842","sources":[{"id":"urn:uuid:7fb0fc62-885f-4fa8-a201-82269de6b4e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9849","original_object":"UniProtKB:P29475"}
{"id":"66b7ac5d-60b8-4ecf-aeca-b162921e8d70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2H6KVC5E76","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:fe5b2ca3-6b14-4d98-aa90-1839aca83dd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4277","original_object":"UniProtKB:P47869"}
{"id":"219038ee-1e41-4315-af29-e640349d793d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11224758","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:f114a6e7-d13c-4854-a8b9-62618c3a563b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8435","original_object":"UniProtKB:P08908"}
{"id":"f34d5015-0e32-4121-a1a9-5fe91c28e52c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:169a3bec-109f-4d5c-9687-f1a02eb4ef4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q969S8"}
{"id":"b8e80857-ef76-48e3-96e0-cacbe5bc19df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3594","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:91a5a916-29e1-4fa9-9b91-08a10d635a4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3594","original_object":"UniProtKB:O60755"}
{"id":"947a7eb4-bf99-46f2-ab2a-3a9223cad669","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OF68Z8HK6V","predicate":"biolink:affects","object":"NCBIGene:8694","sources":[{"id":"urn:uuid:0502d471-ab72-4e6c-abbb-69f073775b94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7828","original_object":"UniProtKB:O75907"}
{"id":"7c4bd828-94c2-4ec4-9eab-aed26de4676d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1505","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:947eaea4-ddb6-45eb-97b3-4ddbb30ab0f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1505","original_object":"UniProtKB:Q63447"}
{"id":"a5cd696f-6b25-41c6-a54c-bfce90be9fab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755040","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:d6972b1a-0fe3-4601-a5aa-14f2b8b70da7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3278","original_object":"UniProtKB:P11229"}
{"id":"dd4ecc80-a75d-4dd5-b7a8-c0cd66f6127c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118522534","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:24b9a138-a24b-4a5b-93ef-127561dbdf48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12318","original_object":"UniProtKB:P29597"}
{"id":"76ed679d-98b9-4a59-9662-86ada5eedeb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16595","predicate":"biolink:affects","object":"NCBIGene:3710","sources":[{"id":"urn:uuid:3e25dbf8-fd40-44db-97a7-f91b2ba206a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4222","original_object":"UniProtKB:Q14573"}
{"id":"77dc5fbb-ce03-44b3-8733-1d8e6229ba76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:449744","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:1938c91c-f55f-449e-a994-d59a708103fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:500","original_object":"UniProtKB:P35348"}
{"id":"49857fe3-887e-481e-b579-2d751dec50cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9882793","predicate":"biolink:affects","object":"NCBIGene:210198","sources":[{"id":"urn:uuid:2dd702f3-f5d5-4afc-ba4e-02727789d6ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:719","original_object":"UniProtKB:Q8K4Z6"}
{"id":"82359c2e-19f3-45ac-ac43-be3a67a9f68b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44450494","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:b87ef680-7796-4c82-a629-10a33ca5a922","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1880","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"7f121466-0fee-4eb7-afb9-c6aa4c19a31b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"NCBIGene:10298","sources":[{"id":"urn:uuid:b836d607-3177-4901-9ec9-60129f5e0786","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:O96013"}
{"id":"9c484a9e-77c7-4678-afab-eb74f53b74cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:119915","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:4a59aa87-1649-4e0a-8361-29201d630dd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1626","original_object":"UniProtKB:P35372"}
{"id":"33fe9e71-0a88-4cc6-aef1-0163cf2d5c80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169262739","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:cd813134-0224-4bcc-95d4-82e7d61f29d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13370","original_object":"UniProtKB:P15056"}
{"id":"ea292ef6-8216-4ca2-b05b-2b3a09b11025","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817417","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:2d6d715f-da7f-4e49-8810-cee9cb7c761f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1508","original_object":"UniProtKB:P50391"}
{"id":"3abeee8e-4501-40b7-ae08-c95341f647b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11773","predicate":"biolink:affects","object":"NCBIGene:7037","sources":[{"id":"urn:uuid:08cd88f6-8060-42ea-a6a0-fdc73bee8f87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11773","original_object":"UniProtKB:P02786"}
{"id":"21f29bb9-11fa-46da-97cf-788825aa1ad7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:6e6a6fd7-cd1e-44ca-b4fd-afb4105c3f3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:P25099"}
{"id":"dc0b762c-9f2e-432a-878f-3fc8b64d339e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:a4c65a02-81db-4c7d-ad2b-f807a90ab6e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P10721"}
{"id":"4cdbd8a5-3cfd-4ace-82a1-15720d3a1ee0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755207","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:ff0cad7d-1171-4cce-a838-6deed2a59c54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6337","original_object":"UniProtKB:Q13255"}
{"id":"01531683-0e12-4af7-b916-9e73cb73a200","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93748","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:eb7c7e4f-c040-4018-baa8-ce9775eaa86b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11207","original_object":"UniProtKB:P22460"}
{"id":"8fc747ba-56e5-4ea1-a711-32bca89ca599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:68667","sources":[{"id":"urn:uuid:256fed0a-11e7-4365-8d3c-19716794e838","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:Q7TN37"}
{"id":"b2d60ff8-4195-4921-bd67-d91d554aea7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3774","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:b89d9103-5637-4a24-acbf-cd2a6a5b551c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3774","original_object":"UniProtKB:P21730"}
{"id":"c1864980-7633-4f6b-8d09-61517841f4ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93078","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:77c6a8fd-ad20-4713-a4d1-80eaa7c15f60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6055","original_object":"UniProtKB:P35968"}
{"id":"15b131e1-9093-4d4e-b843-4901f09d0797","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9867345","predicate":"biolink:affects","object":"NCBIGene:8399","sources":[{"id":"urn:uuid:c5e8e6fd-d2bf-418c-8cd5-01577d3344b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8787","original_object":"UniProtKB:O15496"}
{"id":"24184570-fd15-4b38-a950-1f8ff1e20770","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4085233","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:fd580009-1263-4e69-9dfd-e1c906bd5fa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10281","original_object":"UniProtKB:Q9HCX4"}
{"id":"473a582b-fe66-49cb-be2c-ea6abcd7ee47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2041","sources":[{"id":"urn:uuid:ba87c3a4-caa2-4519-b269-594853e336ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P21709"}
{"id":"e02a5f9f-e54c-4292-8418-e7e35402194b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17407","predicate":"biolink:affects","object":"NCBIGene:81727","sources":[{"id":"urn:uuid:4f909937-be96-4c2e-91bb-29676438c7b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3050","original_object":"UniProtKB:P17256"}
{"id":"14fe6e28-9b1f-4a97-b78b-2347626b3160","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91428","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:3a8ed8c7-49e4-416d-9536-b0c23c435ead","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8244","original_object":"UniProtKB:O00329"}
{"id":"47a13468-ce7b-4d83-9096-810fc90fe1e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1DQI1B52Y","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:de0a6a53-dda5-45e1-89a8-e744ca2abc7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9429","original_object":"UniProtKB:P31751"}
{"id":"0d9368a4-abbf-4f3f-85ee-7e21e3debc2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25077385","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:0053f5ad-4f46-4ed7-bee2-73251344f1b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:607","original_object":"UniProtKB:P35414"}
{"id":"b741e2ca-f26d-4559-90e3-4556284e30b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:93ee55a1-afab-4d1f-9314-31c4aa3b26cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:P12931"}
{"id":"93521c50-67be-4e16-9aed-5eb432c4c4c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5283035","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:87fefe55-8283-40ca-99c6-d41ba36ec5cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1877","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"76272620-261e-4425-9461-0aa30da9681b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6312","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:3a80ffa9-93e5-4724-8f2b-de33f7f54be5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6312","original_object":"UniProtKB:P35414"}
{"id":"c16803a9-2a0a-45e4-871e-c4dc0d50d266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9139","predicate":"biolink:affects","object":"NCBIGene:11309","sources":[{"id":"urn:uuid:6015304b-7564-4931-b322-c0af5257d806","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4743","original_object":"UniProtKB:O94956"}
{"id":"4326ad2f-fd94-4949-9610-1de647e43d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3N422P20J8","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:3f130bf1-ff8a-4595-baf9-8eeb00fbe620","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4368","original_object":"UniProtKB:Q16445"}
{"id":"59bcf95c-144d-4708-8d8e-0e83396e1302","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JUA77QEU32","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:1cc39a47-9fa1-430a-ad2f-f3569a08566c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:272","original_object":"UniProtKB:P34969"}
{"id":"59afd50f-087d-4a6b-a955-82b10173d014","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34496","predicate":"biolink:affects","object":"NCBIGene:29933","sources":[{"id":"urn:uuid:086f57de-f04d-4967-a17b-2a94715467e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5567","original_object":"UniProtKB:Q9UNW8"}
{"id":"9bd1c245-43e3-42cf-9f31-eb57ce25099a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CZ9KU41DVB","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:f68f1749-46c4-43a2-a2d0-a1dc8cbe899b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12568","original_object":"UniProtKB:O75762"}
{"id":"45d1bfba-0d8e-4a03-b019-4f044c5274c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92338","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:ce60e4e1-49c8-4ad6-9cab-65d63709b9bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11742","original_object":"UniProtKB:P27338"}
{"id":"4327a316-3151-46f2-a91b-cf5620d1722a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15343","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:b1ce0fa9-70eb-4aec-8a37-26904223cf28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6277","original_object":"UniProtKB:O75762"}
{"id":"569a49f1-a015-4a2c-a0fe-4aca30669f6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E9M363811V","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:2bf6110a-a6cc-4f4d-8088-937c349d1aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8104","original_object":"UniProtKB:P35968"}
{"id":"9cac13f4-fe9e-45b5-8d19-d81325d12f85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10174453","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:08e5125c-849d-429c-b7af-ceaf45ab3077","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3398","original_object":"UniProtKB:P41231"}
{"id":"779fcd14-a8a7-4d6e-96bf-c171871fda8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132316","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:4e541bab-f328-4803-82f6-d12cc356ab8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1643","original_object":"UniProtKB:P34975"}
{"id":"04e65ebd-11cc-4d74-8b5b-4584684fd4ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O609V24217","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:a82b22ea-e64d-4599-b56d-b9c393f21220","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:980","original_object":"UniProtKB:P21917"}
{"id":"410625f9-7254-4f0c-b628-9d08871a2ac5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50659","predicate":"biolink:affects","object":"NCBIGene:3741","sources":[{"id":"urn:uuid:4bfb548a-e485-4a77-8952-9a0e4d082ab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7465","original_object":"UniProtKB:P22460"}
{"id":"2860f723-4745-48fb-b829-726d8bd5fa23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:950O97NUPO","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:8888c326-c05f-41cc-85d0-48df0b9ced9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5614","original_object":"UniProtKB:P29274"}
{"id":"9b9cb50c-4480-48ae-a380-839f251e35da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2045","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:46fe6c26-a472-4a16-8582-3e1c44200732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2045","original_object":"UniProtKB:P35346"}
{"id":"b6a846fc-0b3b-4086-bfae-5cc23933c580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91790","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:9753e951-1131-4ca7-be16-3e49132f1624","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:186","original_object":"UniProtKB:P41595"}
{"id":"f5bf4aa2-06e6-4952-8bb1-0d19435babee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6241","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:11feb11d-3795-4d57-8000-9deaf9713fd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6241","original_object":"UniProtKB:P25090"}
{"id":"9a420920-7fbf-4b37-9054-71585a34024f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79988","predicate":"biolink:affects","object":"NCBIGene:7068","sources":[{"id":"urn:uuid:6f6c2837-c2e7-4e35-bfcf-e2508fff812f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2639","original_object":"UniProtKB:P10828"}
{"id":"59aecc21-f07e-4932-860e-93c9c628fe9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9568","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:cec843e2-3da3-44d0-924a-bf1529f6d16c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9568","original_object":"UniProtKB:Q96LB1"}
{"id":"8a26d963-d1c0-4ea2-ac84-1f58b2cb0947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134442338","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:d9d199a5-5138-4fba-a3e4-13414a8e856d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13489","original_object":"UniProtKB:P10721"}
{"id":"45c987b2-b15f-4c1d-af5a-958e818f7242","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LQ52UF48A","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:0ccf112d-dd1e-470a-9bbb-39bf526ba61d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5945","original_object":"UniProtKB:P50613"}
{"id":"7989be2f-f9b9-4819-90ee-88c6e4f35b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81528","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:b58909a1-f8b7-4798-affb-4f9c062ee623","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1641","original_object":"UniProtKB:P35372"}
{"id":"412850ae-3cbc-4d3d-8842-6eb144155449","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:921","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:6bc5b435-7260-4449-89bc-18c6b8f666e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:921","original_object":"UniProtKB:Q60748"}
{"id":"c2349d73-7847-4ed7-83fa-cd96083f5b6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73283","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:73134b68-7d7a-49a4-a330-1e65e744bee5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:375","original_object":"UniProtKB:P29276"}
{"id":"3a273d23-204b-44ea-8234-45a228ac516a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10336627","predicate":"biolink:affects","object":"NCBIGene:7512","sources":[{"id":"urn:uuid:71d8b05a-95e9-4c16-80d9-55fb031dc81f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8632","original_object":"UniProtKB:O43895"}
{"id":"ac7b2633-1368-4926-becc-4e4fb8cb1e6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132990963","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:0ea22234-7a99-4352-8923-0a70607fde84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10727","original_object":"UniProtKB:P35372"}
{"id":"285033fb-b987-438d-bda7-4436543f9291","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66558287","predicate":"biolink:affects","object":"NCBIGene:6999","sources":[{"id":"urn:uuid:254eaa6d-4687-45b2-ae11-5f487f414180","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9019","original_object":"UniProtKB:P48775"}
{"id":"87e0ea48-5b38-4381-a9fc-018d6f3e7285","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2551","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:61276c61-82a0-4566-b45c-8d2142cb4463","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2551","original_object":"UniProtKB:P63142"}
{"id":"be048b80-1a38-4fab-bf5c-d40ccd0f955d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4162","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:d26ab77e-48c9-48de-a4f9-eabe8ea35c57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4162","original_object":"UniProtKB:Q13002"}
{"id":"541f6795-88f7-4944-9e2a-d3b47f844c16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996522","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:43581d04-608b-40df-a8de-79775962fff4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10585","original_object":"UniProtKB:P51681"}
{"id":"d9c91390-aeae-442a-8886-95f9ae962423","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5312137","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:b9e9c0ac-cf80-4f94-b19f-a6d6faf1b4ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6044","original_object":"UniProtKB:Q96GD4"}
{"id":"6bfc1853-8b10-428a-bf06-306d882bcb43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL69234","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:e4440a51-0e92-489e-bab0-a6d1848e3942","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1725","original_object":"UniProtKB:P51582"}
{"id":"9fa9e8ad-262b-4057-bd7c-4d9f7be1db99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11477","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:d5da0192-67d9-4131-89d4-7000d2083d28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11477","original_object":"UniProtKB:P51787"}
{"id":"263b9b65-4ae1-48c8-aa42-8cfe5a69ed24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25025654","predicate":"biolink:affects","object":"NCBIGene:12209","sources":[{"id":"urn:uuid:22046e1a-30bd-49e7-84a2-77a139f9fa04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8506","original_object":"UniProtKB:O54798"}
{"id":"1b4b4130-1c56-4df4-8788-38b294158213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:645R07LF0D","predicate":"biolink:affects","object":"NCBIGene:196","sources":[{"id":"urn:uuid:211c64d4-6a2b-4a73-a2ee-90025804da4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11110","original_object":"UniProtKB:P35869"}
{"id":"b6ecc2f8-8ae8-45df-83a5-42896d069fa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2707","sources":[{"id":"urn:uuid:442e8dcb-14c3-43f4-88e7-1479d1ad3968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:O75712"}
{"id":"a5fcbe2e-9e9e-4941-8121-3cbf2925781e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:564AW1RR37","predicate":"biolink:affects","object":"NCBIGene:80228","sources":[{"id":"urn:uuid:e434a3f6-2fe2-4fdc-be4a-8344feb82cd7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10087","original_object":"UniProtKB:Q96SN7"}
{"id":"09dcc321-97e1-42fd-a8e0-7dfcfe83a96e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:5871","sources":[{"id":"urn:uuid:9e360a86-1d5a-4329-810a-96068b7af27f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:Q12851"}
{"id":"84f6e1cb-1d3a-484f-afdf-ae4d39254670","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9591","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:b9503c61-5799-4670-ab32-a8ca33845fab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1667","original_object":"UniProtKB:P41145"}
{"id":"882d33a4-3b22-4942-9998-978a75f2414e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:375519","sources":[{"id":"urn:uuid:b4bf92e4-78dc-4b04-819b-a180271476e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:Q6PEY0"}
{"id":"b70bb4af-feb9-424f-b8b4-b3046c7eb818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:ce726262-e4d6-4531-9907-083aba452f99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:Q62928"}
{"id":"979ca943-fc0c-4847-9f9b-6fd0f3efaf9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1529","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:3e36ecc6-8845-42e7-a695-deac94d42065","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1529","original_object":"UniProtKB:Q61041"}
{"id":"de2f153e-eb9b-476d-aeaa-2d66317cd57c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:5d28f252-b7b4-4605-95f4-b020bd04d56a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P50750"}
{"id":"8d2dcba9-44d7-49a0-9a82-6636947bf1e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8586","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:b56459ee-60cc-4df1-907a-c217e8c69de8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8586","original_object":"UniProtKB:P20309"}
{"id":"aedb4d05-6e21-434d-9b1b-c2d086415f1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130339268","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:af01ba43-a786-4f07-bb5b-6cf9b3611eb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11613","original_object":"UniProtKB:P23458"}
{"id":"d6e3e25b-393c-4636-a3f6-282935c8a81d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8081","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:6185073e-227a-4dc0-8576-69c1b31326cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:502","original_object":"UniProtKB:P08913"}
{"id":"fe96fe50-43f2-4a90-8d72-56288a3aa474","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35056","predicate":"biolink:affects","object":"NCBIGene:5023","sources":[{"id":"urn:uuid:9896ba59-044b-46c0-936d-4b4270288b7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4093","original_object":"UniProtKB:P51575"}
{"id":"4efc952b-f3da-467b-8111-6c7f220de9bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081959","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:d2d3db1f-f6b3-41d0-93df-1225e3c67891","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9871","original_object":"UniProtKB:Q9NQS5"}
{"id":"daa052bf-3ab8-4267-917e-5e271073a9cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5106","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:de93fddb-bcbd-4885-8b0f-63419e15b209","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7076","original_object":"UniProtKB:P04150"}
{"id":"f3160bda-f7d0-44cd-83cb-bfdb0ac0c7a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4874764","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:5ee7c1ae-480f-442a-bebf-a01b29cf9e3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13425","original_object":"UniProtKB:Q14330"}
{"id":"9b179994-890f-443d-89cb-42caa72aefd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166597670","predicate":"biolink:affects","object":"NCBIGene:165631","sources":[{"id":"urn:uuid:e518a0dd-7be4-4d94-a9b1-8ee1c55f3b83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13121","original_object":"UniProtKB:Q460N3"}
{"id":"af0e1c7e-5839-44d5-b04d-575fccf0720a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11963503","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:4fd15569-84d8-4cdc-a2cb-f5cc9818cf8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8688","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"1b0c1192-c563-459f-9b0f-38bd59a2f98d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109558","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:f8cf78b1-7f3f-44c7-bf91-1559d7f43619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1343","original_object":"UniProtKB:P48039"}
{"id":"2f79be73-bc77-4c25-bcb4-6f53daabdec4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139047","predicate":"biolink:affects","object":"NCBIGene:9451","sources":[{"id":"urn:uuid:fa46aa4c-c874-4bc3-9e02-578d2c579e91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9544","original_object":"UniProtKB:Q9NZJ5"}
{"id":"fc4410fe-274d-4b66-929f-7c1c20f88d07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1467","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:a636e5d9-0458-4dd2-ae23-0d61fc7b59c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1467","original_object":"UniProtKB:O43193"}
{"id":"97c7979c-f106-40e6-8a3a-35283c59dd61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1333","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:9eacd135-ca23-491f-9235-7907e8b13fe7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1333","original_object":"UniProtKB:P41968"}
{"id":"ac874858-2f4b-46a2-b147-ed107b41a1f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67376285","predicate":"biolink:affects","object":"NCBIGene:2194","sources":[{"id":"urn:uuid:eccf7322-269c-460f-aedf-871a079f4e19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8605","original_object":"UniProtKB:P49327"}
{"id":"ed0685ea-a398-421f-bf9e-5411a51512ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6887","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:5e8e24bf-5378-4625-b170-4264d467be4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7236","original_object":"UniProtKB:P23975"}
{"id":"11d5ba27-d11c-49e4-9912-d1430ea073a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93641","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:f1aa8ca3-eeba-41c0-9c6e-97466cad7a82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5924","original_object":"UniProtKB:P24941"}
{"id":"d0dea148-6682-450e-a5f1-386986d8e095","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9802572","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:f0f832c5-ebea-4f9b-8b97-adb838206b78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2070","original_object":"UniProtKB:P32745"}
{"id":"8086d9fa-01be-4a6d-86f1-f638590dda92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82701","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:4986a86d-4e01-4e66-a936-cc08747bd9a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6741","original_object":"UniProtKB:P48736"}
{"id":"615a94bd-32d8-4af1-a482-c233a1b0cd26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:c38462ef-5446-47e4-ac1f-03e96587318f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P08908"}
{"id":"f06e6739-47aa-4c6d-8493-680a74b3c611","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15230201","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:895dc46b-16f6-4b3a-82d5-955dd8dcab4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3166","original_object":"UniProtKB:P14324"}
{"id":"a3fae949-8f45-4d24-925c-b443c9bdb20e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:fe0865e2-2226-429d-b10d-93751b23d879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P28335"}
{"id":"1c218c34-9743-4e18-af0f-c410638da41e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2277","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:036d465e-00a3-4f67-ba4d-5a9610cc4188","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2277","original_object":"UniProtKB:P41586"}
{"id":"4574ee06-cfb2-4eb3-8a63-4ec494d0b76d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21779964","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:c2509f75-dff0-434f-96fd-a31669257446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1604","original_object":"UniProtKB:P41145"}
{"id":"18362d55-e862-43ca-a863-361a004660ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11704260","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:53fb0549-46b8-4f6e-b566-879db16030f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4604","original_object":"UniProtKB:P48067"}
{"id":"1be2d1e7-c69a-4591-8b95-ff5184814842","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24885053","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:85a43b86-f7de-4ae9-8d98-6ed29a33f221","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9313","original_object":"UniProtKB:Q92952"}
{"id":"9629cb53-1426-457f-8405-80f769b8c3f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6182","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:935a4fce-d424-4bc2-8d89-ba88ac5e03fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6182","original_object":"UniProtKB:P30550"}
{"id":"a5ea0d2f-2734-4cc5-be2f-b03a0d3a3440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1JL033A2D0","predicate":"biolink:affects","object":"NCBIGene:3685","sources":[{"id":"urn:uuid:a9c3eee7-c105-484c-a255-baf75ea2162d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9689","original_object":"UniProtKB:P06756"}
{"id":"3f673e9d-dac5-4600-9bc0-b1be54b9e6e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135890","predicate":"biolink:affects","object":"NCBIGene:84022","sources":[{"id":"urn:uuid:5aab9cb5-7903-479c-9cf3-6f134632037e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1092","original_object":"UniProtKB:O08725"}
{"id":"95a330ab-ae45-4b17-8ee6-9c37b6e2db0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081971","predicate":"biolink:affects","object":"NCBIGene:838","sources":[{"id":"urn:uuid:461a13de-aa16-4b96-8393-be77f1a808f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9901","original_object":"UniProtKB:P51878"}
{"id":"d28bd441-35fb-4543-8e86-84258404656e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6H35LF645A","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:40be0d64-7c26-4aae-bba7-d50141ed605d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3994","original_object":"UniProtKB:P43681"}
{"id":"b8b47aac-82e4-4ec0-968e-37f97f755d40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1096","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:579667e5-ded7-40bf-aa33-e2328f925f67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1096","original_object":"UniProtKB:Q92847"}
{"id":"28262f93-45a9-429b-afb0-be59c81a4b3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755243","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:9b99dd63-2804-4a4d-af84-36de58c42b4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6734","original_object":"UniProtKB:P17764"}
{"id":"863cd781-8255-45e8-8ae3-8e65613a2cb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:455fb389-9792-4986-b3de-628e85391005","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2391","original_object":"UniProtKB:O14649"}
{"id":"dd580d68-5622-4c6a-a31b-f136c156718f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13316","predicate":"biolink:affects","object":"NCBIGene:25051","sources":[{"id":"urn:uuid:09dc48f7-35f8-4b99-b2b0-bb30cdbe5ab3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13316","original_object":"UniProtKB:P32301"}
{"id":"2e4a146f-9028-440b-91a4-e1398e8f2de8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90679","predicate":"biolink:affects","object":"NCBIGene:23178","sources":[{"id":"urn:uuid:5306ab51-10c9-4df3-b558-1f56486dde45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5704","original_object":"UniProtKB:Q96RG2"}
{"id":"7f116337-e4f8-42ac-a33f-cc44671c5791","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118278442","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:45e43840-9b43-4ed8-bb67-273cff946e82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9908","original_object":"UniProtKB:P31644"}
{"id":"69d1e4d8-0dfc-494e-adef-e086cd7bb5e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358893","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:d739b2a9-70cc-4ab6-8c0f-da475a67e2a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:332","original_object":"UniProtKB:P11229"}
{"id":"0dc33c6e-00f8-4859-a4a0-8d58cc810bf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91336","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:1d0a7198-4b3f-4958-ba1b-d0b856e120ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5718","original_object":"UniProtKB:Q9UQB9"}
{"id":"e12c0595-149b-49e7-b4e0-f0d395659b46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188072","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:d0cb7b97-6404-4364-af68-f1f23102a90c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:67","original_object":"UniProtKB:P28566"}
{"id":"589a32c1-9703-4f4c-9587-0457b2bc7acb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9109","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:a11c9ad0-c3c3-4bc5-93fa-58578e0280b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9109","original_object":"UniProtKB:P07333"}
{"id":"785ef641-839f-4324-9598-59e773952e9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:19216","sources":[{"id":"urn:uuid:11dfce5c-3c8b-45e4-a1ff-1aedd696ef3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P35375"}
{"id":"b6d883b3-86ff-4559-b054-a903727e421d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135679","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:58be1305-f799-446d-a7f7-9fb156e9be1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1586","original_object":"UniProtKB:O95665"}
{"id":"b8a99924-d670-437c-a1a6-b85d76f9fe7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:1a24cb48-238d-4b7a-bd2c-3a6b9a092cd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:P11309"}
{"id":"ff9aa887-c956-4533-b606-10a9fd7a4d93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393291","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:b919c541-23d6-4653-9dc7-6f24540bc9f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10389","original_object":"UniProtKB:Q9Y572"}
{"id":"af550ed1-05e4-4aed-8305-1b8cbc6ad106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:5819e0e8-12dd-4a28-8063-b011dc278200","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:532","original_object":"UniProtKB:P08588"}
{"id":"90879c9a-ebff-4bda-8ba5-c525c8a89adb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169449361","predicate":"biolink:affects","object":"NCBIGene:91746","sources":[{"id":"urn:uuid:0c07699f-cc62-41e2-86a7-1e5a9f23084c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13394","original_object":"UniProtKB:Q96MU7"}
{"id":"e8eab1ad-312e-4269-b901-20b3367f324d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195521","predicate":"biolink:affects","object":"NCBIGene:25255","sources":[{"id":"urn:uuid:8b78634a-acd3-47a6-9e24-e803f77bd5ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8167","original_object":"UniProtKB:Q63470"}
{"id":"c8c5eb78-b3ec-4e26-9bd1-300781df8a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L9P2881C3H","predicate":"biolink:affects","object":"NCBIGene:22171","sources":[{"id":"urn:uuid:331a40eb-f4df-4f58-a72c-8f0b76554421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8278","original_object":"UniProtKB:P07607"}
{"id":"944d9df0-8f87-45bd-a559-7e010f1582b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:ba66f5b2-2480-4866-a156-ef236229869c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:P46098"}
{"id":"f770dc60-8b12-4f77-a9db-3db40b8a5c37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:107681","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:6619149d-ca9d-4ee4-89fe-dcf0aa60431b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6079","original_object":"UniProtKB:P25105"}
{"id":"7246de73-32d4-4f1f-b8a1-01f325a158c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31403","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:d1150219-98f8-488c-a068-44e53e87cd06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9072","original_object":"UniProtKB:P61169"}
{"id":"85d74087-dfbf-4fa9-9b8d-df0d673bdffa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92005","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:ef580656-da55-4672-b843-4ddd11e09fbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:23","original_object":"UniProtKB:P08908"}
{"id":"d3e70fcd-30a4-47e6-bfef-1cabb8012da9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91931649","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:07ec88f1-e60a-42e1-b0d5-418c9262f039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1531","original_object":"UniProtKB:P21555"}
{"id":"949113f1-0852-44e0-9068-c88a7f061d4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10090192","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:496430a7-0916-4660-9b24-d9b8c64194a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2652","original_object":"UniProtKB:P10826"}
{"id":"09b7cb86-8a9c-46f7-b6ce-d314c23ffbb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71059525","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:68612698-2551-4452-83c6-bc528a6e6db1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12211","original_object":"UniProtKB:O14684"}
{"id":"896a3ec6-2119-47ee-a974-1b1f9ba41052","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1559","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:d20ee0af-c3fc-4189-81a0-798620b035fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1559","original_object":"UniProtKB:Q63634"}
{"id":"ec11274f-da4e-4544-bfcd-352cc6b029f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45652","predicate":"biolink:affects","object":"NCBIGene:1134","sources":[{"id":"urn:uuid:c86cc79c-a47f-4be2-856f-a91d3267c670","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4004","original_object":"UniProtKB:P02708"}
{"id":"77b142d4-3ac5-491b-b52e-68acfc15f843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135379","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:21b5de08-df15-4cd0-80a0-13928722a0fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:84","original_object":"UniProtKB:P28335"}
{"id":"def8b587-fae9-473f-80ef-089b1a3ba372","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188626","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:88432e4e-af55-4541-957b-6d3cde622801","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4158","original_object":"UniProtKB:O75762"}
{"id":"e6925500-d31f-42b7-8349-0dcdc3a85b8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89560738","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:7d277616-76d9-47b8-8011-f96487958336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7039","original_object":"UniProtKB:P04201"}
{"id":"85cdee8a-e7c5-4b6f-b0ff-40824c3b1c98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71548412","predicate":"biolink:affects","object":"NCBIGene:225192","sources":[{"id":"urn:uuid:a09f86d8-018a-4632-8b66-3d6aaffbc143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9879","original_object":"UniProtKB:Q91ZY2"}
{"id":"d67b3a6d-9638-469a-b360-b0912989335b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:1acd5307-f6c4-4046-91ae-8a6a4f4b9f3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P22894"}
{"id":"279a013a-9205-49c6-9b30-1af624e12702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081968","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:2d6f4876-7cb8-4305-b4b5-3f1372912141","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9897","original_object":"UniProtKB:P34913"}
{"id":"36f50c25-2fa2-48e3-a4b7-70c90b846477","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91083","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:7a8caae1-e9ee-4964-9f5e-ddcd10f3d468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5056","original_object":"UniProtKB:P09619"}
{"id":"2168457b-8c97-4f11-8da5-90d825750b77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146448902","predicate":"biolink:affects","object":"NCBIGene:90","sources":[{"id":"urn:uuid:79175d60-1657-4167-bdf7-8b89373d22e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12485","original_object":"UniProtKB:Q04771"}
{"id":"445889f8-3296-4145-b664-17613313df4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114756","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:4f00a6ec-876b-4d0a-9d3e-d37a2c003d47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4078","original_object":"UniProtKB:O15399"}
{"id":"b3ac2fcd-8a2f-4600-8859-f362763e1118","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64156","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:3f1bebe6-151b-4b21-a3e8-0ab585864260","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1250","original_object":"UniProtKB:P58406"}
{"id":"5de7de74-ce1f-4cc4-a750-3a8d7f2f248c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8809","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:ce0afd11-5112-4451-8a16-2e0e8f082310","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2491","original_object":"UniProtKB:P15388"}
{"id":"1dd4e926-6088-4e20-a15d-bb4812900720","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46845425","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:29543a8e-5329-4428-bbcf-f1dadaa20313","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8504","original_object":"UniProtKB:P32247"}
{"id":"3e47465e-07c6-4063-b747-023d6d0b5f98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c747d328-9a3a-460a-b538-51cc07cf168c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q13258"}
{"id":"e9160ce5-9414-4a39-a0ce-e3c8623fbe9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138105941","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:416648e6-b264-4fe5-ab02-6f378112dd12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10357","original_object":"UniProtKB:Q00535"}
{"id":"e59a0e56-7adb-4c8d-a57e-55e122eaf38e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1867","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:51726676-2696-4ecf-9df2-15454b49ebe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1867","original_object":"UniProtKB:Q8NFJ6"}
{"id":"105a583f-66d6-4289-95a3-034b506f0ea3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15407","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:b378a6db-8183-469a-a5d5-a23a60ebd5cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:556","original_object":"UniProtKB:P07550"}
{"id":"850d9f78-65be-4100-a6ba-cf610692c355","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6C9UKZ0CYE","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:7b87de93-0796-4f71-ba75-0b48b1b32fde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11281","original_object":"UniProtKB:P08235"}
{"id":"95f7cdd2-5626-4d1f-b4d9-5357e34a33fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89576","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:80f21951-45f5-4e2f-97f7-e79743f85df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:265","original_object":"UniProtKB:Q7Z2W7"}
{"id":"58bfbaa9-0d5c-49db-addb-8beaa6383566","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90682","predicate":"biolink:affects","object":"NCBIGene:5286","sources":[{"id":"urn:uuid:78a060e1-d34c-41e0-8d2d-32c92f17ba1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8839","original_object":"UniProtKB:O00443"}
{"id":"7177c998-bfa8-4b11-8522-9ec156fccfa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:15561","sources":[{"id":"urn:uuid:88bea07c-ae18-446e-9e4c-871b0576182f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P23979"}
{"id":"aef9f3a2-f028-4856-a335-ed81661b3738","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2259","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:4914ec8b-2552-4443-9eca-7b681acb84ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2259","original_object":"UniProtKB:P32241"}
{"id":"123f768f-ff7e-425a-943f-b48d71d27c50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366971","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:30c360d9-6c01-4bea-a49a-f045edb5a437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11786","original_object":"UniProtKB:P08183"}
{"id":"cb2510d8-75b0-4bf1-9099-3fd67bfed45d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:190974","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:1d6a0e7f-c204-48b7-abfb-ed0fe092d159","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5057","original_object":"UniProtKB:P08581"}
{"id":"d705f3f5-9377-4c60-a3aa-4c97eca9f841","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70689167","predicate":"biolink:affects","object":"NCBIGene:9407","sources":[{"id":"urn:uuid:52a834a3-5f63-4dc8-a485-54e555c3ae06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8624","original_object":"UniProtKB:O60235"}
{"id":"fe5467f0-c50d-4121-b569-6329a2b4fa61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15844","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:3428403c-9b42-47e0-b38f-64b4bc0b94cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4224","original_object":"UniProtKB:Q5XXA6"}
{"id":"e8674b76-9926-4959-9e39-72f8de944be8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2344","predicate":"biolink:affects","object":"NCBIGene:276720","sources":[{"id":"urn:uuid:a50e5ef2-4d23-4901-a502-6907ddd606dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2344","original_object":"UniProtKB:O70596"}
{"id":"0e554371-77d6-4e8b-bb0b-5247806f256a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79993","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:bbcf02f5-dc8c-45b5-b753-361a25e27bd3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3442","original_object":"UniProtKB:P37231"}
{"id":"1cb89a43-4877-401d-9983-099a56c1353b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9952446","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:9d89eae8-a21f-4c25-a1a8-1dc42568ac10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4251","original_object":"UniProtKB:P42262"}
{"id":"b77344dd-9adc-4d9f-94bb-25544d860092","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61033","predicate":"biolink:affects","object":"NCBIGene:462","sources":[{"id":"urn:uuid:ac556029-c861-4ebf-9e20-26dd5ae61fef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6819","original_object":"UniProtKB:P01008"}
{"id":"2750bb40-abaf-4c05-bfd6-356675284e7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7939","predicate":"biolink:affects","object":"UniProtKB:O89049","sources":[{"id":"urn:uuid:12f88758-0526-4878-acfe-825845995d17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12428","original_object":"UniProtKB:O89049"}
{"id":"322b3558-690f-4a29-babc-1521dca3c57e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:b912e5a8-0d62-413f-9faf-e978d28f5c80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P32745"}
{"id":"2ffcdc83-da34-4b07-b105-bef7d9998b26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6172","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:409c3a1e-0448-4195-88d9-b1072bbf770e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6172","original_object":"UniProtKB:P28336"}
{"id":"491c6288-13db-4a14-9c8e-0be2fbfbfd2d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11474","predicate":"biolink:affects","object":"NCBIGene:286920","sources":[{"id":"urn:uuid:73f2036b-aaeb-4f82-98b5-b2e4e68f593c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11474","original_object":"UniProtKB:O35240"}
{"id":"4a9c89ac-cb25-4fbe-8fad-a93c7b73a643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231618","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:8bf6c8ed-6d99-4095-a014-f42902c6f042","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2817","original_object":"UniProtKB:Q92731"}
{"id":"4babc060-8150-4fbc-837d-9fe59b902bee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229722","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:4b16f5d6-9143-4bb9-aae0-cc955ccb5215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12073","original_object":"UniProtKB:Q13535"}
{"id":"734e0ed3-578c-44cb-836b-741bbdb55b8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3JL137394Y","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:cd568e6b-81f5-4bea-954e-402738ea82f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7695","original_object":"UniProtKB:P28845"}
{"id":"2470fb01-df8c-48ad-96ec-90d3dc1b1b06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90645049","predicate":"biolink:affects","object":"NCBIGene:5689","sources":[{"id":"urn:uuid:3f5d0747-6f4b-47a6-b1e6-65acfb3f3d73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8618","original_object":"UniProtKB:P20618"}
{"id":"ea678ae5-3034-4b75-8eee-7409caad1168","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"UniProtKB:Q9JJX6","sources":[{"id":"urn:uuid:79e41b6c-38d8-46bf-a7aa-74a24eca1153","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q9JJX6"}
{"id":"6222dc20-e6e4-4490-af58-6e3d92fd6a98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:28234","sources":[{"id":"urn:uuid:24210b81-2d5c-4cae-a751-5ca5b69113e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:Q9NPD5"}
{"id":"42febd18-3a23-4fee-94b0-16493de10ed9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9RL37ZZ665","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:be604c65-7a55-4bc4-b23b-e1f3f962b2fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7816","original_object":"UniProtKB:P09619"}
{"id":"5352e39c-3274-4622-ad86-8021f35c11e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48273","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:5b44a567-e49f-4be2-91a1-d78336a3fdfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:51","original_object":"UniProtKB:P08908"}
{"id":"61d12594-5343-4598-acfd-8829c5d8816f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77936","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:3490f671-db2a-40d1-8284-735b5b8a10ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5280","original_object":"UniProtKB:O00763"}
{"id":"a85261d1-77b3-401d-ac02-66bcccb3360d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154733031","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:9ea4e76a-9943-40a5-9d7d-b4628be3a2f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11261","original_object":"UniProtKB:P32247"}
{"id":"d9f486c8-ae09-425f-87d5-da9617d7b164","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118110201","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:311f3b16-47b3-482f-bc8f-202422450d2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12320","original_object":"UniProtKB:P30530"}
{"id":"ac506f60-c6fe-457e-99b5-cb922c2f2992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5123","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:25b1fc49-b98f-455b-97f1-e20cadd9f140","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:204","original_object":"UniProtKB:P32305"}
{"id":"f62aa272-8942-4752-9145-c60181426d16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310960","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:6718e931-b263-451e-ae38-8227d6a02439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:459","original_object":"UniProtKB:P0DMS8"}
{"id":"e9e5a091-5f3e-4ff1-a94e-26eedfbcf13b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50138","predicate":"biolink:affects","object":"NCBIGene:347411","sources":[{"id":"urn:uuid:05bb8d1b-0f03-405c-b2b3-6678586608f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12601","original_object":"UniProtKB:P0DKB6"}
{"id":"26e7fd32-ed18-496d-a58c-1a958eeba1be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3188786","predicate":"biolink:affects","object":"NCBIGene:2840","sources":[{"id":"urn:uuid:3ea71318-708e-4195-b237-a47a78b49fd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5519","original_object":"UniProtKB:Q13304"}
{"id":"26736f96-4efa-4969-9739-58cbe98f43fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311459","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:6b570599-58ff-45b2-a857-c4d643ba5bae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1418","original_object":"UniProtKB:P31424"}
{"id":"ef812d77-c959-4514-8bb9-c9c0c1c9313d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90217","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:fa6a3731-c15b-42ff-95d0-8ae26c12b54c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5658","original_object":"UniProtKB:P10721"}
{"id":"70466f1b-773b-43f2-91ba-92533419acc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3037130","predicate":"biolink:affects","object":"NCBIGene:4158","sources":[{"id":"urn:uuid:57892070-f220-44bb-adc9-fbdcd06a576f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1332","original_object":"UniProtKB:Q01718"}
{"id":"35146e65-21fc-40a4-9edb-b789b95ed57d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2509","predicate":"biolink:affects","object":"NCBIGene:89822","sources":[{"id":"urn:uuid:47107875-532f-43a7-967a-bbdeb954a41f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2509","original_object":"UniProtKB:Q96T54"}
{"id":"21555256-aee9-4e23-9b8a-beb8c2079a1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92637","predicate":"biolink:affects","object":"NCBIGene:836","sources":[{"id":"urn:uuid:c5293ec8-34a8-4021-8031-4853ae111225","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5143","original_object":"UniProtKB:P42574"}
{"id":"0928fd67-1fe8-4bbc-97d0-59dccd1e54e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR6E47E4WN","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:b02cd6a9-3759-4743-ba90-9bf45ae3e216","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3165","original_object":"UniProtKB:P14324"}
{"id":"32961405-32ff-4cef-b532-48441a33b235","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8531","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:be82b2c8-b39a-4dd4-8298-6eeab295b6f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8531","original_object":"UniProtKB:P61073"}
{"id":"8bdda428-01fb-4976-b7e6-26c5ce7e1744","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32010","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:1c0a9cc4-d1b7-4456-b4d1-f63c81e1cd47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4288","original_object":"UniProtKB:P48058"}
{"id":"6af6be20-8c09-4ad3-80b4-6de4bf86edc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13827","predicate":"biolink:affects","object":"NCBIGene:43740571","sources":[{"id":"urn:uuid:3601e0b7-32ee-493a-920b-6a37c1b8e440","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13827","original_object":"UniProtKB:P0DTC5"}
{"id":"08083909-615b-42b9-a250-3ecb5c36abce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817471","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:8386c5a5-c0f3-4807-8ac9-c2b4357e2f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4449","original_object":"UniProtKB:P70555"}
{"id":"e7013958-8ff3-411f-8145-b36af66cbc23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166642477","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:cb3bd397-1c9b-4cc3-b41b-cadeee9afe02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12356","original_object":"UniProtKB:Q9BY41"}
{"id":"96a3af7c-9ea8-43db-8619-437ca7e1103e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3756","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:627d4d5b-89ad-4ce4-9e83-37133566b974","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6963","original_object":"UniProtKB:P14867"}
{"id":"d32c12a9-e2c6-4d6b-a41e-126a255d0135","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44433047","predicate":"biolink:affects","object":"NCBIGene:8720","sources":[{"id":"urn:uuid:76127398-db27-4d31-97b6-66d51d8a7ce4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8828","original_object":"UniProtKB:Q14703"}
{"id":"b2cf4453-4a94-4e01-b65b-53610f0b92dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:a9c5f7bc-4e47-445a-baae-238e8481df49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P35462"}
{"id":"4aa7a3a7-52a1-4d11-a57e-02acf7ee004e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163409083","predicate":"biolink:affects","object":"NCBIGene:6654","sources":[{"id":"urn:uuid:c7cd0525-fa85-41c1-8700-c36b6f97bed2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12069","original_object":"UniProtKB:Q07889"}
{"id":"09f4485b-50a4-49c3-8799-16cd2c7ef4f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9HGW1H8S2M","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:54ddb730-3fdc-480a-b434-8b496343c150","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10242","original_object":"UniProtKB:P23219"}
{"id":"a4e4f95c-c132-489c-85cc-c9fe48bd5294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92401","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:d3bdbb17-3d03-41e9-900e-760ca0f63e0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7505","original_object":"UniProtKB:Q9UBN7"}
{"id":"253e3e08-f3b1-4983-a76c-91e5fab75895","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146013180","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:27b37955-8e2e-42ff-a952-199c060d4ede","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13212","original_object":"UniProtKB:P07949"}
{"id":"e2b5dcee-6511-4e14-921a-83e459805224","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136042","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:e27e2cf2-040e-485a-8d7c-f556f0c6578c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9906","original_object":"UniProtKB:Q6V1X1"}
{"id":"934354f3-0860-4093-a37c-5e52c955e644","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25125014","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:c8fce0eb-39e6-412b-ab4a-0404c4f5e54a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8176","original_object":"UniProtKB:Q00535"}
{"id":"4577de0e-74e1-463e-b824-214d8bce8f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:2101","sources":[{"id":"urn:uuid:9028fc93-c29b-4b48-a6cd-2b51b7449b5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:P11474"}
{"id":"bebed05e-b421-4827-95de-3ed53ac57002","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:54758482","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:a2e1a96c-850d-46f9-a1b8-b199ef4d2b7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8215","original_object":"UniProtKB:O14757"}
{"id":"8be58f20-df94-4732-82b0-1b95eb061018","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2062","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:5c557993-5008-475e-9499-3d924d5c5521","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2062","original_object":"UniProtKB:P35346"}
{"id":"4568de92-8e4b-4d6a-a21d-139433de2174","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659967","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:39854254-9aaa-41fb-9601-362758e3fcb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6345","original_object":"UniProtKB:P23385"}
{"id":"54e4180e-d0f1-44ea-9bec-5c6c703b3339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:770","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:6f640ed0-3783-460e-aefd-f836bab0b87e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:770","original_object":"UniProtKB:P51681"}
{"id":"f061d971-b6f5-43a2-aac3-14f9d902ee9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2162","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:0173ce52-c189-44a4-a11f-e5b0095dd963","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2162","original_object":"UniProtKB:Q9UKP6"}
{"id":"18e752b1-e089-40ac-b721-0fd3986b7d32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"NCBIGene:19065","sources":[{"id":"urn:uuid:4a424477-15a6-407b-9593-1b6cdf0bc8fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:Q61041"}
{"id":"37350dab-9ac5-42fe-bed4-ac2703175875","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101879981","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:dcf7e7e6-987b-4ab4-858e-8f7a1d704f0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9010","original_object":"UniProtKB:Q9GZQ4"}
{"id":"6cd0c69e-61c8-4276-b287-765871726d20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188559","predicate":"biolink:affects","object":"NCBIGene:5916","sources":[{"id":"urn:uuid:31c7a35d-8eb3-4386-bc99-bee45072b119","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8276","original_object":"UniProtKB:P13631"}
{"id":"75ee7de8-c334-44fe-961a-ddb8cfe6c8df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2058","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:3cfde780-7674-490f-a611-d4518bfe81e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2058","original_object":"UniProtKB:P32745"}
{"id":"f78c6321-ddc1-4d43-9eff-da086ebb2cb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40730","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:ac36656a-763f-4023-a8fa-b030cedc1afe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5092","original_object":"UniProtKB:P21589"}
{"id":"edfc0c3e-565a-428d-9509-1f640792f04c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6120","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:33408c94-c3ee-4c52-a076-62b32dd679df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6120","original_object":"UniProtKB:Q62805"}
{"id":"42cc09dd-349f-4501-94d9-e6bb449adaa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68595","predicate":"biolink:affects","object":"NCBIGene:5476","sources":[{"id":"urn:uuid:4422d653-02d7-4fa1-9117-9f6cf9a20ab7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7871","original_object":"UniProtKB:P10619"}
{"id":"3289bafe-7b98-4948-96c8-534b6ef94b0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311372","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:46ad4399-af1a-49c6-9bc4-eb28ed29dc5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2050","original_object":"UniProtKB:P30680"}
{"id":"e0a2fb04-78fa-4131-9315-3e6d660f74e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13787","predicate":"biolink:affects","object":"NCBIGene:255738","sources":[{"id":"urn:uuid:434a1054-9cd9-4ec2-a939-4d9997f99dd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13787","original_object":"UniProtKB:Q8NBP7"}
{"id":"6db47335-7e94-47b4-b8cb-b4ba37ee9545","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29009","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:3df610e0-9e8d-4142-a777-580778901383","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1242","original_object":"UniProtKB:Q9Y5N1"}
{"id":"34fca4f0-050a-42b7-be72-91f2491e8fd4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16264","predicate":"biolink:affects","object":"NCBIGene:140795","sources":[{"id":"urn:uuid:fc9c9d35-b0ef-47c8-8848-48a7c4f94864","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1779","original_object":"UniProtKB:Q9ESG6"}
{"id":"c9548364-9520-4b7b-bef9-b29fbe0a6015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155925850","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:63b45fd7-6b2c-4908-827b-3eac37dd55d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11565","original_object":"UniProtKB:O60674"}
{"id":"c50bff46-8342-4a4e-9488-446367cc4132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593561","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:3686c280-db2f-424f-9b93-653bf21674de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10530","original_object":"UniProtKB:P11802"}
{"id":"440d378f-c0f0-4773-b20e-31af7a91dffa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180498","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:944a189f-9d19-4f07-9204-56a24b23aa62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4355","original_object":"UniProtKB:P32249"}
{"id":"5cb6c4d2-ec30-4c07-a9c2-367e3dc948f6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RN3X97C29H","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:19aa600e-76fe-416e-a30f-93acb4095b30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:783","original_object":"UniProtKB:P41597"}
{"id":"8eeb604b-d689-4f16-8558-aa69d1119787","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9892288","predicate":"biolink:affects","object":"NCBIGene:39","sources":[{"id":"urn:uuid:d416a9fa-ba49-4f6b-89f3-61941730755e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10150","original_object":"UniProtKB:Q9BWD1"}
{"id":"c7e936d0-d2b0-4690-b68e-962a1cbc33c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:681850","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:bf0af773-2208-46a8-ad87-a1926cfb5872","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2203","original_object":"UniProtKB:P30518"}
{"id":"ce9915cd-6b66-44f5-831a-df84da46265e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:19ORU63E06","predicate":"biolink:affects","object":"NCBIGene:3832","sources":[{"id":"urn:uuid:fecaa901-2f1e-476a-972b-383245464244","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7708","original_object":"UniProtKB:P52732"}
{"id":"3be0c9b5-bbfd-49de-8a64-7923ca1640f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:aebb92f1-85df-43f9-b9ed-2f3860e674c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:P28476"}
{"id":"638fd45a-6e1e-41dc-b24c-030cdda5c10f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57336054","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:dc34de7b-be29-4a3c-affc-9ce1e1edc266","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11233","original_object":"UniProtKB:Q99571"}
{"id":"8f78cf94-cdab-41dd-97d0-541914ac1088","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3970","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:5e9d6e26-5487-4134-8c10-41a0b534e475","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3970","original_object":"UniProtKB:P32297"}
{"id":"deac736b-27d1-4ebe-9157-b97c4db78c8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16973","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:df504d25-4aa8-4d19-918c-4b4ad66ec03b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2871","original_object":"UniProtKB:P04150"}
{"id":"ca2594da-a15a-4043-adb4-21cfa0766ad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:05HYK3CV9N","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:02d222c2-3f82-44b2-964d-3cb95bb94095","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10466","original_object":"UniProtKB:O00329"}
{"id":"a26d8d61-fedf-497c-a725-371f5cc7093a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072550","predicate":"biolink:affects","object":"NCBIGene:27443","sources":[{"id":"urn:uuid:c6916caa-f160-4e8e-923a-654a0ab4fea1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8951","original_object":"UniProtKB:Q9BXF3"}
{"id":"c9dac2dd-e842-47c3-a45b-020faea45a52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817418","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:93461090-d06c-4a89-ada4-abc27b3a951c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1510","original_object":"UniProtKB:Q9ERC0"}
{"id":"e3c8475e-fa82-408a-9870-da7a530c6c6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YET2XNU791","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:17b8f501-f476-4090-bc29-b0b4687d8303","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10461","original_object":"UniProtKB:P24941"}
{"id":"4e8129be-6b2f-4189-ab02-20cd3e3233db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0K5743G68X","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:fc7a6cf4-87fd-4cb8-b279-a80b681df2bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9302","original_object":"UniProtKB:O43614"}
{"id":"23b39a66-a65e-4dc9-9170-53664d5c8683","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:612","predicate":"biolink:affects","object":"NCBIGene:14829","sources":[{"id":"urn:uuid:b2834bb3-ce14-4fcf-aaeb-a82c26d01c97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:612","original_object":"UniProtKB:P21729"}
{"id":"6150bcec-d5fe-47a1-97a8-24c03feff3ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1166","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:322c4b62-f2d2-484b-b6a9-6995f7ebbca6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1166","original_object":"UniProtKB:P30968"}
{"id":"6cb215b5-3caf-4ba4-844b-62c24c48652b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:337294","predicate":"biolink:affects","object":"NCBIGene:59272","sources":[{"id":"urn:uuid:b2353480-53aa-471b-9bfa-dd193921b11f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7867","original_object":"UniProtKB:Q9BYF1"}
{"id":"c8d5a07a-90c2-48cf-a687-b0d97c81bde0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:eb3bdb04-4164-45ee-9fcb-ec390606c5a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P08483"}
{"id":"5b22b048-170f-43fb-9315-f11b3582d745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137029447","predicate":"biolink:affects","object":"NCBIGene:6595","sources":[{"id":"urn:uuid:8b1081b0-523e-4afa-876d-2eaa1ed7780c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12206","original_object":"UniProtKB:P51531"}
{"id":"c676b958-327f-48e0-8b9d-1c51e6287019","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5300","predicate":"biolink:affects","object":"NCBIGene:839","sources":[{"id":"urn:uuid:61357961-f1cd-47d8-81ee-cc226bb5438a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5300","original_object":"UniProtKB:P55212"}
{"id":"fae9393f-6b08-42f3-a0b6-29d8b474619f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156735923","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:70aa8c74-05fe-4c82-b082-087008679698","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12687","original_object":"UniProtKB:Q06187"}
{"id":"e877a5dd-dba5-4281-9220-b72051f9a227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155434855","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:8c75ba23-61d8-4e98-b815-182b6ab66a73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12096","original_object":"UniProtKB:P04049"}
{"id":"4adf5505-5823-46b4-ac1d-d17d4bdb6a4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827387","predicate":"biolink:affects","object":"NCBIGene:4924","sources":[{"id":"urn:uuid:63c9894b-6f18-47ad-9e4a-b73262673bb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8702","original_object":"UniProtKB:Q02818"}
{"id":"4b5cb0ab-a616-4cd8-a693-7e85850da579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947040","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:af09e918-138b-4471-85bf-a5fe2d058afa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3014","original_object":"UniProtKB:P51639"}
{"id":"67e8e04c-26a5-4969-b9fd-31c0fb7f18a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91362","predicate":"biolink:affects","object":"NCBIGene:6795","sources":[{"id":"urn:uuid:fa855057-de17-4a3f-951e-12662f5595a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8358","original_object":"UniProtKB:Q9UQB9"}
{"id":"f1392efe-2462-40fc-a08c-023e4ac04cc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10124","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:ce0ec4ad-d291-4854-a01a-30348ed17165","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:60","original_object":"UniProtKB:P30939"}
{"id":"67948b35-0842-49b6-be68-39bfa28ac8ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2210","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:6d361953-60a7-4695-9841-921e409a81b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2210","original_object":"UniProtKB:P30518"}
{"id":"d0f089c1-ca62-4cd2-8ee4-eb188f6e6a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8228","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:61168eee-91d1-4151-9bcd-30441ba8676a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2694","original_object":"UniProtKB:Q9HCF6"}
{"id":"4805ecf8-7b84-4fec-a1a0-1872adff2f75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34973","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:66c6e5cd-b68d-4e4d-9111-c38557c83bb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4155","original_object":"UniProtKB:Q13224"}
{"id":"e204cd5f-f5d0-4343-bd7d-2d05774fa2f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10037815","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:2de7ba01-0d1f-4d56-93b6-c09a4527221f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1206","original_object":"UniProtKB:P35367"}
{"id":"0fd51db2-e398-4bb1-8ae9-fa1f5885c840","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1496","predicate":"biolink:affects","object":"NCBIGene:2831","sources":[{"id":"urn:uuid:e5e35535-27f5-45ba-9985-8cf1f2957291","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1496","original_object":"UniProtKB:P48145"}
{"id":"03fa50d1-d9fc-43e9-9513-17d6c77b0a2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71611462","predicate":"biolink:affects","object":"NCBIGene:699","sources":[{"id":"urn:uuid:137bf796-0bf4-4575-bf33-a0334a0732ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9126","original_object":"UniProtKB:O43683"}
{"id":"5c98e501-75ae-4cab-ae8c-a86e72cada08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3662","predicate":"biolink:affects","object":"NCBIGene:10663","sources":[{"id":"urn:uuid:48f632c9-7838-497d-b004-ef8135435bf1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3662","original_object":"UniProtKB:O00574"}
{"id":"8a6e4b4f-7a9a-4217-a2f2-b9078aa8ac51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11537456","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:c746342f-7d6a-4421-991d-2dbabaa6df6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6354","original_object":"UniProtKB:P23385"}
{"id":"99e132f7-1963-4db1-a0d1-8aeae7f3b1b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135743630","predicate":"biolink:affects","object":"NCBIGene:6999","sources":[{"id":"urn:uuid:8b4a93f8-c3d5-4f6b-9b61-9c09602f9dd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9016","original_object":"UniProtKB:P48775"}
{"id":"59c09da0-94ce-43d2-9235-96674eb423a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8522","predicate":"biolink:affects","object":"NCBIGene:128674","sources":[{"id":"urn:uuid:338eba8f-1992-42c6-bd5f-3c9f401e1d91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8522","original_object":"UniProtKB:Q8NFJ6"}
{"id":"646ac50a-cad8-4820-940c-e37f34f490bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:95899848-907d-4bbf-a2e4-62a68049f3e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P21731"}
{"id":"66a9a4c0-ee6e-4497-95a9-89ce5043d94f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110187","predicate":"biolink:affects","object":"NCBIGene:7166","sources":[{"id":"urn:uuid:a3d0f8ae-0249-4cad-8c6b-327824ce33b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5240","original_object":"UniProtKB:P17752"}
{"id":"f5ba104e-3491-4478-bcff-5f64e02aa456","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103966","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:d0a141b9-f28a-4feb-afd6-8f97d28820a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6077","original_object":"UniProtKB:P21918"}
{"id":"f6167b35-3d20-4723-a0c1-2e831ffb1a7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:776","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:9facaf4c-993b-4eff-ba81-d7bf19792d51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12965","original_object":"UniProtKB:P03372"}
{"id":"bbceb4fd-e7ba-40f9-8b66-2f1fe9a928ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10301396","predicate":"biolink:affects","object":"NCBIGene:3680","sources":[{"id":"urn:uuid:8f0bc4a2-a3d9-4fd8-adc4-1c7692657f26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12045","original_object":"UniProtKB:Q13797"}
{"id":"32953967-4a0c-476d-b241-c005d7b35310","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LQX7RFK8MZ","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:35938140-c3a7-4535-b624-0f113a2955c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11622","original_object":"UniProtKB:P21802"}
{"id":"24c77adc-22be-44f1-8a9f-8883307436aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:50835","sources":[{"id":"urn:uuid:f1f19f4d-4af1-4b96-9e9a-be9b938cc893","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:Q9NYW1"}
{"id":"07977796-24f1-41c3-9a8d-5f7935304c23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2185","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:0b40d501-a66c-4fab-9e31-b22c87fc1bba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2185","original_object":"UniProtKB:P37288"}
{"id":"face5255-2cf1-4cde-9f4b-ce7509498b6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72795","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:48d5bde1-68a5-4049-bc8e-75ce446b5336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6160","original_object":"UniProtKB:Q9NPC1"}
{"id":"6a5745b3-36f1-403e-b588-d4c5c62425f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57345941","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:69baabd1-0f8b-4fe7-ba96-0a276e38982c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10474","original_object":"UniProtKB:Q12866"}
{"id":"40ca7be4-e58a-4a07-ad73-753ac44ba7cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91380","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:9a7627e7-60bf-4f14-9f0b-00baecad4d9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11665","original_object":"UniProtKB:Q5S007"}
{"id":"d3f27e94-4b3c-4b07-b313-4e614da367b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:84329","sources":[{"id":"urn:uuid:f1975a75-4e04-4357-bd47-84959fae76d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q96D96"}
{"id":"2979f1af-f211-4c1c-8dd5-c5da683be12d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9864","predicate":"biolink:affects","object":"NCBIGene:920","sources":[{"id":"urn:uuid:13ec7174-c480-47e2-8387-33a611d504e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9864","original_object":"UniProtKB:P01730"}
{"id":"1dc70e18-a9af-4005-a731-efd43ee528a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:51a659fe-a69d-4de4-ad34-28991dfbecc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:Q9H3N8"}
{"id":"b46def86-b6cf-4754-b2fb-672e18618493","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92489","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:24c3c431-2b3d-405d-abb8-f32b9b5b783b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2927","original_object":"UniProtKB:P21453"}
{"id":"4a3934df-9e57-419f-bfed-1fb4203a1f0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656733","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:c49a49b4-2fdc-4762-b9e7-b26280d5de12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2320","original_object":"UniProtKB:P70605"}
{"id":"dfc112d4-9505-425c-b0b2-0012ffb63f3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75170","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:5ad93826-2eed-4078-bf6b-c66df7001390","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3057","original_object":"UniProtKB:Q02769"}
{"id":"c27d9c63-30e7-43c4-a918-9bc9e5ffc2dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4092332","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:2f146f93-4d94-41d9-a6d3-95f8f02c3928","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:12405","original_object":"UniProtKB:Q16445"}
{"id":"197ee85b-d393-445c-b69e-868b41d82826","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:773HER9B6T","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:56cc1ef6-fa5f-4fd3-b01f-701013b2da96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4218","original_object":"UniProtKB:Q12791"}
{"id":"cf5068ed-ef56-46d7-ab66-43bb2d22edf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925664","predicate":"biolink:affects","object":"NCBIGene:8726","sources":[{"id":"urn:uuid:79f295aa-75c8-43d3-ae3b-40a46c4cf6f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11784","original_object":"UniProtKB:O75530"}
{"id":"b4365ecf-5a76-42bb-9402-3dfbea49d275","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167655","predicate":"biolink:affects","object":"UniProtKB:P49356","sources":[{"id":"urn:uuid:541ac6a3-d2b3-4989-b46e-fe104fa86db0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8026","original_object":"UniProtKB:P49356"}
{"id":"88957ded-c3cf-4db7-8902-e7f0867899fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947011","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:42d58303-1448-4065-a0bc-d7a99dc914d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3126","original_object":"UniProtKB:P37268"}
{"id":"d8993e96-fa10-401a-bf53-9797e336f4f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10270","predicate":"biolink:affects","object":"NCBIGene:9002","sources":[{"id":"urn:uuid:7d21b94e-1100-490e-994f-ed9c0779a4c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10270","original_object":"UniProtKB:Q96RI0"}
{"id":"4d86100d-166a-4f27-b41a-27a37767348f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U3T5W003VP","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:e071889b-2a43-4514-9611-b57d46e94676","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11730","original_object":"UniProtKB:Q06187"}
{"id":"ae4daca6-9701-4da0-9fd6-0323d32f2fce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61397","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:f27f1bc2-6d05-4f5e-8a45-0dc06a39477b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5686","original_object":"UniProtKB:P04626"}
{"id":"339633aa-30f1-481d-aab2-3525b3cdbfbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177662","predicate":"biolink:affects","object":"NCBIGene:1591","sources":[{"id":"urn:uuid:0b18229f-2f29-4903-9d24-0e043674a33b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11382","original_object":"UniProtKB:Q07973"}
{"id":"146244e8-1a68-4bdf-9839-055f03147786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14407285","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:e6bc81e7-a7e0-4405-b89a-1ed29ba5cbbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11560","original_object":"UniProtKB:Q9UGC6"}
{"id":"018f64e8-0d67-425d-bba5-c02b20e21a52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10097314","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:1cfb75b0-2442-4b0e-aa7b-78c717a565e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5650","original_object":"UniProtKB:Q8TDV5"}
{"id":"8e7a06dd-3c31-47b1-a35f-98859fd8562a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679547","predicate":"biolink:affects","object":"NCBIGene:1240","sources":[{"id":"urn:uuid:821db599-d6fc-411b-9d23-6f5f003f7160","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11936","original_object":"UniProtKB:Q99788"}
{"id":"8162feea-70e0-4f35-bc8e-32f9e20c44e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:DRU6NG543J","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:9d81667b-ccfc-4ddd-805e-2e4680f149e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7837","original_object":"UniProtKB:Q06187"}
{"id":"32acfdc2-c214-46cf-9c7f-341cad965312","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:aad2eefd-3af9-4050-a1e5-b582310e11c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P28566"}
{"id":"0111d010-d46c-4b14-99dc-d81b71c65369","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11281345","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:d25a53e4-101d-4e23-b909-0c31f1e7a443","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6258","original_object":"UniProtKB:Q14416"}
{"id":"e737397b-c151-40fe-913a-edf9b1423c7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92943","predicate":"biolink:affects","object":"NCBIGene:6536","sources":[{"id":"urn:uuid:676ab8df-6f0b-441e-91e3-1ca12b2e76fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4618","original_object":"UniProtKB:P48067"}
{"id":"0dbcbea6-4ca6-488a-ad9d-bf9751a2000d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4521NR0J09","predicate":"biolink:affects","object":"NCBIGene:23411","sources":[{"id":"urn:uuid:e1edc8fc-90bc-477a-9f78-f0bd82411918","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9515","original_object":"UniProtKB:Q96EB6"}
{"id":"d6173dc2-3fc4-4183-a70b-161f14786380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5122","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:6907f6a8-57c2-44dc-a356-674d9f7088e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:279","original_object":"UniProtKB:P31388"}
{"id":"eb6bd2c5-46a3-4297-94ff-5eb5282d0be6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71506845","predicate":"biolink:affects","object":"NCBIGene:10110","sources":[{"id":"urn:uuid:9794f33e-e75b-40a1-8647-d7b14ae3290c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9423","original_object":"UniProtKB:Q9HBY8"}
{"id":"92017541-aee7-485d-a39a-ef62252b1e5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9863342","predicate":"biolink:affects","object":"NCBIGene:20182","sources":[{"id":"urn:uuid:cfb708c4-b20d-4b9c-b122-bc5a1f467e51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2811","original_object":"UniProtKB:P28704"}
{"id":"7408f9f4-f130-41fc-bc28-a757c151e820","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12504","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:9d38ccae-975c-4e72-bbab-6529300ea8f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12504","original_object":"UniProtKB:Q8TDU9"}
{"id":"4c774fdd-bde6-4e75-b52b-fbe1ea0f8bcb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137319706","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:0523c849-de48-47f5-b457-588d0a2690f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12175","original_object":"UniProtKB:P43220"}
{"id":"00566560-0f4b-40a5-84f7-f079555837e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162366965","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:91e5e2f8-c9b0-42c1-af9a-a62c152fcee6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11732","original_object":"UniProtKB:P78527"}
{"id":"5e83e3df-88dc-4220-b40e-9088eb9e8416","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230775","predicate":"biolink:affects","object":"NCBIGene:1515","sources":[{"id":"urn:uuid:d1305835-9167-4f3c-a1b7-021fb181f6e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11377","original_object":"UniProtKB:O60911"}
{"id":"771cc8ac-ea9b-4192-94a1-efa908fd5fca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2189","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:c73a79d5-5d76-4e31-a18b-a350c25e15ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2189","original_object":"UniProtKB:P70536"}
{"id":"8d901b07-895b-4a00-9615-dcacd968851d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138628908","predicate":"biolink:affects","object":"NCBIGene:657","sources":[{"id":"urn:uuid:a5cab76a-6919-4f68-a198-138903e64eb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11888","original_object":"UniProtKB:P36894"}
{"id":"489d3e1b-3437-413e-bd64-17abeb5888d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:935afd41-3c70-4507-84b7-c38e706394a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P28222"}
{"id":"dae47291-e75b-4843-900e-d5ef2b25f2a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92762","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:46eabe52-7494-4ae6-bd17-51a4cb383656","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:274","original_object":"UniProtKB:P50406"}
{"id":"8a0b2d39-feda-411c-aae3-c1dbcc4592e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118522534","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:9fb8d56c-76e0-4f75-aefb-8a782c567c10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12318","original_object":"UniProtKB:O60674"}
{"id":"fa5ad404-c456-439c-9a04-171633de2a0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167312378","predicate":"biolink:affects","object":"NCBIGene:345275","sources":[{"id":"urn:uuid:463d33d8-07a4-4a60-8c8e-b84a80995bd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12478","original_object":"UniProtKB:Q7Z5P4"}
{"id":"9471b10e-16db-459a-b6ee-4dd9ff9a1142","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11206949","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:7fcb0e15-b47d-4af3-8c31-7b7adcf9bb19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6447","original_object":"UniProtKB:P41594"}
{"id":"2af9b859-f328-46af-8d28-8a3e9fd02957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:2348141d-5c8f-4d44-82c9-7a9743eb8df4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P10721"}
{"id":"6dc8169d-02c1-49fa-9638-31cf295e04e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131967","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:2459d29b-417b-42e2-84bb-3785a1239041","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1046","original_object":"UniProtKB:P25090"}
{"id":"18f57af8-0bd7-48d4-ba73-e7cc14abe6e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3542","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:515e3c91-c954-4f41-914c-4f4fa68701eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3542","original_object":"UniProtKB:P48546"}
{"id":"35c08b49-b535-451f-beb4-8b7b6a99df11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107660","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:b6dc8d21-2c1c-4443-bd13-81ddba174ef4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2361","original_object":"UniProtKB:Q05586"}
{"id":"6ff346a8-aeae-4f1c-b4a3-f05766645c44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:0b84d9a1-5408-4450-a62e-db93f9c84877","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:O94759"}
{"id":"467eb972-1239-49a0-84a4-8da674423a4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:42ee1e29-ac82-4e68-bc07-cb0b2fd5de11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:P23458"}
{"id":"a2504d5e-8b40-43c8-a5fe-bb4e56b54452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679536","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:6de497d7-0e1e-4a84-94b1-5b26b2b2f467","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11846","original_object":"UniProtKB:Q9GZU1"}
{"id":"b9977e4d-5728-46c8-b8e6-9773d9e65f8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13797","predicate":"biolink:affects","object":"NCBIGene:6272","sources":[{"id":"urn:uuid:8028e6c9-5cad-42b9-b407-6774357244ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13797","original_object":"UniProtKB:Q99523"}
{"id":"3beac450-2640-42f6-b339-0af129768bed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817486","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:e01f4013-84ff-48ff-9822-6507474ddf1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6123","original_object":"UniProtKB:O88626"}
{"id":"01f7380d-be79-4893-87ef-7403c7c4dee2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2DRZ23E4F7","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:f59cbc97-faac-47df-8633-03d9f8bff2c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5619","original_object":"UniProtKB:P30543"}
{"id":"c7098094-1e4a-4c4c-b919-ecb89111c1e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194186","predicate":"biolink:affects","object":"NCBIGene:2696","sources":[{"id":"urn:uuid:7842fd48-9ec4-4570-8681-141bc54604c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11429","original_object":"UniProtKB:P48546"}
{"id":"d22e3109-5a8e-4376-88ee-6e25a0eed9cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:5110ddef-e810-4ab9-912e-fa12f5982039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P13945"}
{"id":"358b9e37-fcab-40e2-93d4-96b3c8a9d0c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232587","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:fd5435d6-3cc4-489e-bd7a-3e8d516e81c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9527","original_object":"UniProtKB:O14744"}
{"id":"430b07e3-e1fd-44f0-901d-4a1afffa5ed7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FQK825B5DX","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:35a253d8-4afc-4924-87ea-74a2543a6e53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8862","original_object":"UniProtKB:P22455"}
{"id":"f30d7570-5277-4181-a6b0-9dd6c41a8f00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E1V875I8DX","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:8d936025-a594-4968-8510-4697c9852175","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6057","original_object":"UniProtKB:P35968"}
{"id":"4759b60a-309d-4317-a640-21367bcee298","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10078814","predicate":"biolink:affects","object":"NCBIGene:5225","sources":[{"id":"urn:uuid:272722ce-f9a9-4dec-8415-dd97160a6bfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8634","original_object":"UniProtKB:P20142"}
{"id":"c50eda21-a709-4a70-9d9e-b1ecf9c84620","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71466","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:af1de3ff-5a49-4787-a5f9-26173fdc699c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2661","original_object":"UniProtKB:Q07869"}
{"id":"4969bad2-5ea1-4146-8f8c-0b13bb5d00a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4319354","predicate":"biolink:affects","object":"NCBIGene:29933","sources":[{"id":"urn:uuid:83117b12-69bf-46d2-9fda-1ca274d30a0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12944","original_object":"UniProtKB:Q9UNW8"}
{"id":"76fea253-0be2-4466-bd7d-86129dcf4f54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58392644","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:d7d4ba5d-a4bc-4cf7-b6b7-f472f26fa226","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10005","original_object":"UniProtKB:P04150"}
{"id":"80200c51-3155-4f52-9d21-fd4330480783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131409","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:9a0a1a3c-2b54-4139-9aa9-d793bd3a64c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6086","original_object":"UniProtKB:P47211"}
{"id":"bb0129d1-d5cd-483d-9408-c416fc7f84ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27552","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:df713674-0435-42d8-99e5-bca9fa211a00","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10299","original_object":"UniProtKB:Q9HCF6"}
{"id":"d980d560-9f6f-4f00-a856-b22634216441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310960","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:5a165ec5-eb27-407b-9295-f886f6689e08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:459","original_object":"UniProtKB:P29274"}
{"id":"037bea93-09ed-4d7b-ada2-a1f8595c6b1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16181638","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:66b3c326-34bd-4f6a-a4e9-00790a698065","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4161","original_object":"UniProtKB:O15399"}
{"id":"7ad07164-2bd9-4425-9cfd-5ef765804286","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2524","predicate":"biolink:affects","object":"NCBIGene:1565","sources":[{"id":"urn:uuid:69469339-af26-46b2-ae8b-adebc0008ee4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8746","original_object":"UniProtKB:P10635"}
{"id":"84ba6397-f062-4579-bd58-7e73e2a27877","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827386","predicate":"biolink:affects","object":"NCBIGene:23569","sources":[{"id":"urn:uuid:f06f3071-74d6-4148-8df7-24624b2547db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8684","original_object":"UniProtKB:Q9UM07"}
{"id":"a49882ee-7dae-4445-85cb-72676bd280a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6101","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:bc789cb6-eb42-4e6c-94a6-884773b29b63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6101","original_object":"UniProtKB:O60755"}
{"id":"17c1f195-0cae-4c2c-bcc8-58d9316728ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34605","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:dedd34fa-bb28-4d90-a99a-f6fd5f6b7b59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4165","original_object":"UniProtKB:P42261"}
{"id":"dea0a978-c6d7-4e4e-9b51-0a73e7a8aed5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q2640DPW33","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:8636e133-97e8-4c9c-a4d5-8aa7aca015d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10724","original_object":"UniProtKB:P35372"}
{"id":"54627481-0eab-418d-a23a-46af5aacdeb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91357","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:78c86a84-7b99-4a5a-9e4b-bd78d305cd1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8007","original_object":"UniProtKB:P35968"}
{"id":"05cb9101-c4bb-426d-99fe-63053e3ec206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135796589","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:1b96781f-d749-4044-a70d-efeb587032fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4512","original_object":"UniProtKB:Q99808"}
{"id":"aead57ce-1612-4e11-96ae-da56d14f6d6e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17865255","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:a44308f7-0b44-4e17-9458-95c4ee712f2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5436","original_object":"UniProtKB:P11229"}
{"id":"f08259c5-d5ff-4faf-98a7-6553823cbe04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1174","predicate":"biolink:affects","object":"NCBIGene:14715","sources":[{"id":"urn:uuid:9997422a-56f0-441b-bff9-9c7734cb08bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1174","original_object":"UniProtKB:Q01776"}
{"id":"776febd2-a716-4088-9eb6-9b2f550bceaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5893","predicate":"biolink:affects","object":"NCBIGene:222236","sources":[{"id":"urn:uuid:20fed890-3064-4bb4-b47e-237439f3519b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:7203","original_object":"UniProtKB:Q6IQ20"}
{"id":"6fef359b-580d-49bc-a8ad-2a994b311634","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30830","predicate":"biolink:affects","object":"NCBIGene:27198","sources":[{"id":"urn:uuid:180090a7-ac9f-440f-96e5-3a0f747cbc97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4711","original_object":"UniProtKB:Q9BXC0"}
{"id":"4b40b195-7c7e-498d-b92b-a637c4de0db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78373","predicate":"biolink:affects","object":"NCBIGene:5581","sources":[{"id":"urn:uuid:5ee4cc12-75f1-4b22-9041-0a873c19b1f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5953","original_object":"UniProtKB:Q02156"}
{"id":"cfaf582f-8ba2-4191-8828-293a16b4de48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134846","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:6d831e52-e029-4084-84eb-f08d0368939a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:306","original_object":"UniProtKB:P11229"}
{"id":"e8800beb-2105-4d96-b7fd-5506dd7dd5c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91799238","predicate":"biolink:affects","object":"NCBIGene:1902","sources":[{"id":"urn:uuid:b3b86612-38de-44a0-af1b-8db05f62c871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8588","original_object":"UniProtKB:Q92633"}
{"id":"4dd30f18-d024-466c-b0c8-b3330725daa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11743147","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:70b40bf0-8e19-49a1-af50-e0e81c641a80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5851","original_object":"UniProtKB:P43119"}
{"id":"8bd5a569-6a3a-436a-86d7-1284775da579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13637","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:0b27e33c-b202-4736-a977-c2806a7cab42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13637","original_object":"UniProtKB:P08172"}
{"id":"ffe10309-1eb6-4bab-85f3-6eaccef9ead2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:B1X701S0MV","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:330c4680-e7da-4b7b-b773-9c276054d176","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1595","original_object":"UniProtKB:Q8TDS4"}
{"id":"805c4c12-f81d-4429-b28b-b7069094cc53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195326","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:cec7747d-896a-4d69-8c4f-06ee2dc57826","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1323","original_object":"UniProtKB:P32245"}
{"id":"c7d412fd-2be1-4421-b550-0921e6621e96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80308","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:8f48f8f6-02e8-4819-910b-29ffa78e9e70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2098","original_object":"UniProtKB:P25103"}
{"id":"e8c61b28-aee2-4536-87dd-c16a666bf1f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3DGD69C6PV","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:f659c5d3-a05a-4ece-b20a-eada6526471a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7741","original_object":"UniProtKB:P08069"}
{"id":"379c7500-618b-4264-8ff6-522d2114e20c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817489","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:7757249a-13a2-4893-9041-87e4129cf2a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6166","original_object":"UniProtKB:P28336"}
{"id":"ac2442e5-fb8d-4433-82be-fbf944644457","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:803c4813-1ba1-47eb-8089-30cf7fc30357","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08912"}
{"id":"f44e4334-1a6c-42b1-9627-9b63032c0549","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73386882","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:a3a77848-6b68-4785-91fc-e290605ef58b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9169","original_object":"UniProtKB:P33981"}
{"id":"f5dceeaa-a2b1-4cc4-97a8-dd33e75c8d6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129188708","predicate":"biolink:affects","object":"NCBIGene:747","sources":[{"id":"urn:uuid:56bdc31b-ee9c-469e-9c86-8432471238a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10243","original_object":"UniProtKB:Q9Y4D2"}
{"id":"71c920f2-8a08-4c72-861a-2495056b1b7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:79858","sources":[{"id":"urn:uuid:c34197e1-6226-479e-84bf-9834e62998c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:Q8NG66"}
{"id":"1207ab35-4fe6-4aa4-9627-92254ba40bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12009","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:8a114e83-d9ca-4cbc-a3f3-5a9e9999baeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12009","original_object":"UniProtKB:Q5S007"}
{"id":"351127c4-524a-4c08-9bf9-6b204020bd1a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9460","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:b9214d2a-2cb7-4377-a00b-0a284c0010fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7303","original_object":"UniProtKB:P11511"}
{"id":"dc7f7084-2f4c-488f-825e-b954632a262b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138628908","predicate":"biolink:affects","object":"NCBIGene:658","sources":[{"id":"urn:uuid:22f8a1c9-df81-44c7-82de-a1af1da4cf5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11888","original_object":"UniProtKB:O00238"}
{"id":"68953504-ddc0-4f75-9fb5-46cf85e07c9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230504","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:36eea4a9-f4cc-485d-b38b-660a4713e929","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8237","original_object":"UniProtKB:Q15910"}
{"id":"8e8d7843-b8da-45eb-9a9e-76d0753a28e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11960895","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:f9ba8fe1-5363-4d7f-a7ed-a1402d23e8c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9304","original_object":"UniProtKB:O43614"}
{"id":"8b7c2a81-507f-4c64-b100-a3b391bc8880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TN7CUD1NGA","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:0975c6aa-a634-41ba-ac24-0eead24a9727","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11414","original_object":"UniProtKB:P22607"}
{"id":"33092a30-b1f1-49b3-a0d4-73a589f94ff2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947075","predicate":"biolink:affects","object":"NCBIGene:13611","sources":[{"id":"urn:uuid:01fe539d-bda9-4eb3-9922-5416c2864a69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2923","original_object":"UniProtKB:Q9Z0L1"}
{"id":"cc2b3b59-9e1c-444f-bd7c-7b5f73389762","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:54263","sources":[{"id":"urn:uuid:51cb6af7-8982-4301-991a-9a223f1e3b69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P70605"}
{"id":"a8451571-805b-4ba4-b537-582749977857","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:919","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:73bde587-5d48-46de-8ad7-5161648b4f6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:919","original_object":"UniProtKB:Q13324"}
{"id":"5ba39272-de2a-4325-bc81-dafbbebb7fef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9566","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:eec313a5-0d41-4398-9e23-e0b712e2dcd5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:100","original_object":"UniProtKB:P32305"}
{"id":"cd4e9b9d-446a-4ecf-98cf-4bde38e68f2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16164","predicate":"biolink:affects","object":"NCBIGene:760","sources":[{"id":"urn:uuid:9a028fd5-b0d4-4685-b61d-49a7dfa74f39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13596","original_object":"UniProtKB:P00918"}
{"id":"cf11b963-600c-47d5-b8f0-02c58c2c43f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3S9RX35S5X","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:c8555b2d-90a3-427c-99fb-332a93d4d5cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8952","original_object":"UniProtKB:Q9UBN7"}
{"id":"cd5a4a78-6e67-4a1b-850c-5be49ef9022c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2637PDX9SI","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:ed1d69d2-32c9-4285-a35d-0e61f88e23bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:873","original_object":"UniProtKB:P32239"}
{"id":"9e093822-53f9-4dd4-8dd3-9e9634cef4d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162641720","predicate":"biolink:affects","object":"NCBIGene:23043","sources":[{"id":"urn:uuid:5657b5f3-ad26-4655-b863-17393e9ebfab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11833","original_object":"UniProtKB:Q9UKE5"}
{"id":"a67f0ebe-af6d-4b46-a37e-771d65463c70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1545","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:3b556a6a-850d-4a2e-b963-bf93755f84da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1545","original_object":"UniProtKB:P21555"}
{"id":"1b11f2f0-7cf8-4388-b9ba-f8a49e1fabb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:48a1c17e-f8f7-45f9-8576-a73080593224","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q7Z2W7"}
{"id":"79dd702d-7415-450e-b88b-07980f4eb37b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:772CP7W12N","predicate":"biolink:affects","object":"NCBIGene:887","sources":[{"id":"urn:uuid:5f0e2787-bdbf-4e4a-8747-d619b976e899","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:888","original_object":"UniProtKB:P32239"}
{"id":"28f1cc7d-dfbd-4a50-8749-a184d113d263","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:492392","predicate":"biolink:affects","object":"NCBIGene:50837","sources":[{"id":"urn:uuid:55246abf-a479-443e-b232-63856bcb0666","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12436","original_object":"UniProtKB:Q9NYW3"}
{"id":"ed7401ff-5384-456c-ba97-721df85e1988","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101615586","predicate":"biolink:affects","object":"NCBIGene:1565","sources":[{"id":"urn:uuid:12b17ab9-49fe-47d8-bda6-8b8c47df9a7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13592","original_object":"UniProtKB:P10635"}
{"id":"a18586fa-4228-409c-a5f7-b3580ef54682","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131512","predicate":"biolink:affects","object":"NCBIGene:5740","sources":[{"id":"urn:uuid:8829f203-63e6-4beb-835d-3c879d945d60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5281","original_object":"UniProtKB:Q16647"}
{"id":"56097cb5-f17f-4991-8a68-b05e8d846829","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16051023","predicate":"biolink:affects","object":"NCBIGene:5347","sources":[{"id":"urn:uuid:781ba92b-2560-4394-b2f3-c2730e5d22af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8150","original_object":"UniProtKB:P53350"}
{"id":"920dff50-b506-45d0-ba98-1f12f244bdfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623363","predicate":"biolink:affects","object":"NCBIGene:7150","sources":[{"id":"urn:uuid:117f25fc-66b5-4d1f-8206-71daa2752874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8261","original_object":"UniProtKB:P11387"}
{"id":"680276c5-5d91-42e0-9ff9-106ba7f28f6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6H81G454I7","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:b77c9baf-1dd5-4fac-b817-061d99edc0b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7678","original_object":"UniProtKB:Q14416"}
{"id":"a8ef3b10-c764-4e5a-bb8d-1b490774c000","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94306","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:3033a28a-9ab0-4c5a-99ce-730b4ac83006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9664","original_object":"UniProtKB:Q9UBN7"}
{"id":"c424d801-bb74-4b76-b4c3-8396b96959b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6G5F6ESV5I","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:930687de-b8ef-4153-b45c-f48f0bbc352a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:71","original_object":"UniProtKB:P08908"}
{"id":"34256dc1-f63d-4cec-ac0b-552c50f286c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9821498","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:6848aca5-f7dd-47f9-80a7-e13f45d40d5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:167","original_object":"UniProtKB:P31388"}
{"id":"800ce5f5-acee-4ae2-b7d7-bec111b433c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90195","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:ad7934ae-a769-43db-8382-9e809dd84a51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8367","original_object":"UniProtKB:Q13547"}
{"id":"a8ddbcf0-2021-44ba-a6fa-155eff504de1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66855377","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:6485686f-0507-4c45-9d2f-771d1d0209a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5906","original_object":"UniProtKB:Q9H244"}
{"id":"008cf440-808f-41c9-9c4b-1edb188c31fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:059cd68c-465c-4e0b-9a95-37dc77463480","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P16234"}
{"id":"845830db-369d-418e-b886-603e2737b620","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71727668","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:111295aa-27c5-47dc-a44c-b7a77667ab38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9803","original_object":"UniProtKB:P23458"}
{"id":"8a6a2dd0-8deb-49c2-909e-7163e7458da8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72944991","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:a6396041-5153-413e-9321-95ff2753b622","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8509","original_object":"UniProtKB:P32247"}
{"id":"e5209ea2-807b-4c8b-8e86-c75f8dcc5ebf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44467360","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:db4639e3-6629-48a8-a5f4-7763e3e17adc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9197","original_object":"UniProtKB:P56817"}
{"id":"e1953cd7-fba3-4479-8795-a04a6f3de110","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1501","predicate":"biolink:affects","object":"NCBIGene:2832","sources":[{"id":"urn:uuid:d71cf998-207a-4d31-ae9b-2b428fa46ad1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1501","original_object":"UniProtKB:P48146"}
{"id":"43cf3680-0887-4abb-aa64-1f4496b19bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195398","predicate":"biolink:affects","object":"NCBIGene:4314","sources":[{"id":"urn:uuid:34d5cf1e-edb1-4c14-a796-004e599a46d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5145","original_object":"UniProtKB:P08254"}
{"id":"ad65367e-9367-4867-bf0b-49b583b2c77d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"UniProtKB:P35560","sources":[{"id":"urn:uuid:8a6eb8d2-60b9-43f8-afed-83e230d493ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:P35560"}
{"id":"369eac46-e8fc-4717-8ef9-c3a480127d2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79995","predicate":"biolink:affects","object":"NCBIGene:7376","sources":[{"id":"urn:uuid:8812a0a1-fd97-4314-bb53-efe3505bf3a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2754","original_object":"UniProtKB:P55055"}
{"id":"34d87bb9-27f7-40df-b430-e9012895743a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2252724U5N","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:47c696ca-bb0e-4f82-9067-225e33491262","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7647","original_object":"UniProtKB:P00533"}
{"id":"efe03704-38b8-41f0-ba4f-71ba005b7c1d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1125","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:c21364e6-0f29-4fd7-b5f6-0219245f11c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1125","original_object":"UniProtKB:Q02644"}
{"id":"7049f28e-0db7-488e-ba8c-dbbada0a05ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10028830","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:25c1f328-0e27-4f24-b5b6-a77a87be9500","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3932","original_object":"UniProtKB:P13945"}
{"id":"cdd93588-9ec3-4a04-9f35-bdeb5cadec46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92223","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:ed33c6c5-bfc7-4587-8db6-8178c9f044c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8366","original_object":"UniProtKB:Q13547"}
{"id":"ea0ae7b5-01ee-40ec-96e4-1badfff77e92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2613","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:145b523a-d3a3-45f8-8b80-1984130af319","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2613","original_object":"UniProtKB:Q9UQD0"}
{"id":"f71cd998-0a11-4bdf-b4de-df76cfe2bdc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:7e96fb28-280e-4349-a4dc-92330dd96b33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2844","original_object":"UniProtKB:P29274"}
{"id":"cb07747a-7590-437d-8208-035098162830","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135903","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:47004b6c-b400-406d-8472-29d21be7f4b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2086","original_object":"UniProtKB:P25103"}
{"id":"60aa06af-e3c5-4f07-acaa-0d0f9e793797","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90687","predicate":"biolink:affects","object":"NCBIGene:10498","sources":[{"id":"urn:uuid:95df0717-1e22-49ba-ab6c-b74650173100","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9258","original_object":"UniProtKB:Q86X55"}
{"id":"b44e6c02-7508-4269-836b-45549f354220","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:101085","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:ca9ff98f-ded1-4486-973a-98e23d132de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6807","original_object":"UniProtKB:O43570"}
{"id":"88e27b61-5fd8-43b6-85d2-b202e46c6ef8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EW71EE171J","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:6230633d-e2bd-46bf-b961-dd4520eaf3b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:185","original_object":"UniProtKB:P28335"}
{"id":"c3c1a898-9a55-4ef2-ad38-5e29d0d56daa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2613","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:4f51b81f-947a-44ea-96b0-426a75192c9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2613","original_object":"UniProtKB:P35498"}
{"id":"0e96df1c-e50c-4254-a700-ae28413dce29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34807","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:2fe5fe5a-505d-4d8d-bc33-acd0349c257d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2592","original_object":"UniProtKB:O43526"}
{"id":"94160d71-d3b7-4be2-aa75-92ba1fcc03e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:114756","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:0d3e2ba6-07d1-49b2-9fa8-0dd27340fa44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4078","original_object":"UniProtKB:Q13224"}
{"id":"e9a14f9d-db51-4efd-a047-9f0b7989b414","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8058","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:53a82468-5ff2-412f-a294-9f62f0110469","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4282","original_object":"UniProtKB:O15399"}
{"id":"a9fc46ea-52b1-4bb4-b0e2-8dfb83d0166f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12544","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:0ccb0b6e-90ec-47e5-9aca-52ab1c7ed0bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12544","original_object":"UniProtKB:Q8NER1"}
{"id":"f2d2fda5-9f58-4dd2-ae85-1091e87f4c34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0W13ZI072Q","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:2dcc632c-ab10-491d-865c-db34f1e37732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1664","original_object":"UniProtKB:P35372"}
{"id":"6bcd0d5c-9fa3-4936-bad4-f076d071d6a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:cb307221-2254-4d72-82d1-bc5bed55478c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P17948"}
{"id":"46e95f08-e974-4cdd-837d-cd90727a95ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827346","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:b8c43623-c683-472d-927f-b2b22f7891c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5622","original_object":"UniProtKB:P29274"}
{"id":"e3856ce0-9cf9-4ae8-b80a-e09fd5968232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XO01711URG","predicate":"biolink:affects","object":"NCBIGene:2830","sources":[{"id":"urn:uuid:390af3d9-3c1e-43fc-ae4a-ff442a058711","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11514","original_object":"UniProtKB:P46095"}
{"id":"c45eca04-fd45-437c-8964-9c79ae576b37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34888","predicate":"biolink:affects","object":"NCBIGene:1188","sources":[{"id":"urn:uuid:24a4271c-fa33-4946-b1d3-00c7152b7ad4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2439","original_object":"UniProtKB:P51801"}
{"id":"0e1a3753-e59b-447d-a860-53151fc4cacd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135566612","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:98d9447a-9111-459f-9aa2-27ca3304edd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8172","original_object":"UniProtKB:P42681"}
{"id":"2e94f588-3091-4c9f-9f22-e504f5a2e412","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:662a993c-f960-40e6-81e7-2b10c1341556","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P43140"}
{"id":"a4665589-7742-4a6b-b242-00c9159396ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:dd8ddbd4-8c0f-41ed-a693-10c52db6cb1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P34980"}
{"id":"332b56bf-8018-49ab-9d46-b92e1ce0552b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:ef902b1a-7cdf-4f4b-8100-7382e86ab684","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P14780"}
{"id":"9774bb48-4644-4eb3-99ec-75ac900417f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2466241","predicate":"biolink:affects","object":"NCBIGene:340024","sources":[{"id":"urn:uuid:a1ad42f8-10b6-4879-b6b3-f4fce98ef981","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11227","original_object":"UniProtKB:Q695T7"}
{"id":"754cfe4b-6a7d-4035-ad6e-414e6d8e6f08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11753159","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:7bfcd6f9-f7c7-4c54-a7c4-9dc97298fa4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7679","original_object":"UniProtKB:P51677"}
{"id":"2eb0c537-2c1e-4e41-9dc1-66611729457e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156440741","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:e4c9fe5f-acbc-4606-bb14-0dc17144229f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12375","original_object":"UniProtKB:Q12866"}
{"id":"a922ce35-f65c-4b55-a4e8-0c9cdcdd97d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9221","predicate":"biolink:affects","object":"NCBIGene:5657","sources":[{"id":"urn:uuid:b5bddc16-57b0-4e33-9916-29f66b3583e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9221","original_object":"UniProtKB:P24158"}
{"id":"764f18bf-06f9-403c-838c-ab53cb8db4b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:49de0817-6c0e-49fa-b27e-193c686127db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q8BLA8"}
{"id":"e4562ea2-f24f-46ea-9a6f-5ddc4d5f2ea6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135652","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:2ac2075e-f814-416b-8079-c14c939e90be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12488","original_object":"UniProtKB:O95180"}
{"id":"da493396-edff-47fb-8044-87b0d2722332","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138911338","predicate":"biolink:affects","object":"NCBIGene:6195","sources":[{"id":"urn:uuid:960f4dfe-b8c5-412c-8e75-837be8275855","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10437","original_object":"UniProtKB:Q15418"}
{"id":"94b29d67-73ef-43ca-b50f-ce1fbb0ad7f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91435","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:84e25604-cb89-4c4a-bf87-97a5dd794cf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5657","original_object":"UniProtKB:P10721"}
{"id":"8f8cddae-3ca5-4ad7-a331-70e5bb2c5c3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2219824","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:0702f9e7-4ff0-439e-911e-630460086cd1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6713","original_object":"UniProtKB:P48449"}
{"id":"87ffa202-5b38-4f3a-a641-6581f0a4261c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817417","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:421ac09f-9034-4963-bed0-1dee2c2337a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1508","original_object":"UniProtKB:P49146"}
{"id":"466765ee-c9df-4e26-a01e-a7f150fac8ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91885483","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:88f3b8ef-2946-4dc8-9aed-82edddf1d496","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10009","original_object":"UniProtKB:P31424"}
{"id":"7a7cc887-8560-431c-83c5-f022c5181e51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GJ0EGN38UL","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:02f221ce-54ec-4290-b741-c7da2c70c1bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5867","original_object":"UniProtKB:Q92847"}
{"id":"380f0505-72bc-40d5-a711-7f3bf05716d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6979053","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:30fe7c49-06d1-4fd0-8e71-c45e838fb050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:288","original_object":"UniProtKB:P08172"}
{"id":"3de1963d-ace8-4209-8574-3d6cba9e967f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92636","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:87ea89ec-7e7a-468b-8232-a1b8a4566df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5288","original_object":"UniProtKB:P45452"}
{"id":"a1287e88-30c8-4ae2-9724-a8ab8673d102","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15428","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:9600675d-3780-4ba8-9807-dd069d46464f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:727","original_object":"UniProtKB:Q12879"}
{"id":"f8d909fe-aa6a-4450-ac76-c4ee511117a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7928","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:4743f11b-9ec6-47be-be72-7c273945353e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7928","original_object":"UniProtKB:Q9GZQ4"}
{"id":"99c3d591-3426-4b83-b028-ae2d06ffa8eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82713","predicate":"biolink:affects","object":"NCBIGene:1432","sources":[{"id":"urn:uuid:594c297f-ae26-4c9f-8755-b82881062f06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6038","original_object":"UniProtKB:Q16539"}
{"id":"b5e8e024-4194-43c7-bca1-e7a980b7c463","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8925","predicate":"biolink:affects","object":"UniProtKB:P29319","sources":[{"id":"urn:uuid:d2b4e938-ef9f-443f-86d1-0c58e1c6f630","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8925","original_object":"UniProtKB:P29319"}
{"id":"e19f00b2-4363-4740-be8f-10540de359ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LG47VG1ID","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:e80a5ca3-b37a-431c-8e99-855ea0cca008","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:380","original_object":"UniProtKB:P30542"}
{"id":"2ed20204-c44f-4876-a16d-e4cdb0809912","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1578","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:42adaaeb-869f-4a37-9403-1caa90cf14f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1578","original_object":"UniProtKB:P70310"}
{"id":"ed201a7a-6d73-41a9-879c-30c4d7f2253e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2008","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:cc03a0e2-b24b-4a54-ba0b-547c57396f2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2008","original_object":"UniProtKB:O08858"}
{"id":"94cda08f-38b2-40a5-aff0-f772b7871e39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1680","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:965a435a-92b4-489f-8b3e-726367dae417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1680","original_object":"UniProtKB:P41146"}
{"id":"4c9e7b85-c8f1-4766-a208-8496ff6f1e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:85f6dae6-2e23-4b42-9517-7e5e26f0bf9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P31391"}
{"id":"eb2f8438-67e9-457a-ba51-8a6ee44325f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T4RS462G19","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:b86e46de-b06c-456e-956c-6cb2362648e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11136","original_object":"UniProtKB:P00533"}
{"id":"2e0354a5-10c3-4c01-bf93-c3e85f8e8540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51066","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:ac98e229-fe1a-479c-a35e-9dcf5be0598a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7155","original_object":"UniProtKB:P25100"}
{"id":"02b0f72f-ef4b-463c-a10e-785a72267f3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135018","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:594ef0e9-8bb3-485b-9afe-80235a701ade","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1610","original_object":"UniProtKB:P32300"}
{"id":"2b6fdf76-aea7-4171-bdc6-74a5aa2e285a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6102","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:fdca15d8-e366-4bf3-9892-19257ed114f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6102","original_object":"UniProtKB:O60755"}
{"id":"bdca21c1-4d9f-4e61-8671-b012a195e6e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4325","sources":[{"id":"urn:uuid:fa68853d-b8fa-46a2-b88c-c3098be564b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P51512"}
{"id":"4dc7b985-8564-40b9-88f8-761bc0ad9d6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311001","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:e48229bf-d603-4e3b-995c-d59bd5393c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:341","original_object":"UniProtKB:P08172"}
{"id":"9108c846-5a8d-441e-977c-2d9044c3e6bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LN4A42V962","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:eebaaf5b-e826-46f9-bbff-5ebad9189022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10241","original_object":"UniProtKB:P23219"}
{"id":"ea3560da-3367-4569-b75d-a6106cfb99fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5421918","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:37dcb3c0-37dd-40f3-816b-d6316d6cb2e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13407","original_object":"UniProtKB:Q6RI86"}
{"id":"b0af4e85-f91a-4f99-990d-0882675b9447","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17053","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:d00ca6af-7d25-4bae-b95a-c60860a4fa40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3309","original_object":"UniProtKB:Q05586"}
{"id":"dc21becf-f051-465a-bec7-e0635df2375f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AC7QO6038O","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:59dc80de-40d7-4484-948c-c6c67a279e1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6308","original_object":"UniProtKB:O75762"}
{"id":"2e3285f1-6c15-4591-969b-8a7c9d8c3ff6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16618023","predicate":"biolink:affects","object":"NCBIGene:9429","sources":[{"id":"urn:uuid:3d7a184b-9e0a-423e-bc4d-52e277ac772a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"non_competitive_antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10372","original_object":"UniProtKB:Q9UNQ0"}
{"id":"00b2f17b-d1c4-45b6-bbd0-b7e923c1162a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111174","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:646d51a1-3d85-453b-aef9-754e91246118","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:309","original_object":"UniProtKB:P08482"}
{"id":"dec21890-8f67-4bd3-95fd-396df1459d21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8238285OA","predicate":"biolink:affects","object":"NCBIGene:230777","sources":[{"id":"urn:uuid:7ba8e008-d721-48fb-baee-2e21569e9912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9307","original_object":"UniProtKB:P58307"}
{"id":"d25f9873-93e1-42a7-8eb6-83acd79ea6cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16131028","predicate":"biolink:affects","object":"NCBIGene:24807","sources":[{"id":"urn:uuid:e7cd12fc-fcf1-4205-a37a-a4e807a9175b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2097","original_object":"UniProtKB:P14600"}
{"id":"b91916a1-9195-43c0-8228-a780c1955dc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:8f03544b-42d1-4018-b3fb-4b047bf98fba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P29274"}
{"id":"88b384f8-f12f-4ea8-b593-97e7b81706b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58221549","predicate":"biolink:affects","object":"NCBIGene:9020","sources":[{"id":"urn:uuid:da86d73c-d01c-4fc0-825e-d37da488439f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12186","original_object":"UniProtKB:Q99558"}
{"id":"c144d088-7878-42ee-9126-f69cc3749a7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:c07057e8-2726-43de-9b4e-d4fabd3b4ae8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:Q9BWU1"}
{"id":"d4633d18-ae1f-4384-a3f0-29dd9bea3714","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:2e97f613-6e26-4410-947a-e5ba9aab5abb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P32305"}
{"id":"89d5f6d5-fb4b-40c7-8ec8-08d7b8c979d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:100126572","sources":[{"id":"urn:uuid:db69fe02-2ebe-48bf-8e4f-5e9efe0d881d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:A6NN92"}
{"id":"91ac96c3-8edc-4616-b50b-40e27051afa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94449","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:c938af26-c72f-4f77-aed5-9a61fce1783c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7459","original_object":"UniProtKB:P08172"}
{"id":"8e0ca851-518c-48b3-8947-c58be7194452","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136189563","predicate":"biolink:affects","object":"NCBIGene:5587","sources":[{"id":"urn:uuid:cc149f1d-2102-44d4-acba-a76ce8278905","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8048","original_object":"UniProtKB:Q15139"}
{"id":"a34a31f9-6739-4846-83bc-9fd755205660","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2668","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:44d7d6e5-30a2-480b-b8d5-85afcce9c9cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6981","original_object":"UniProtKB:Q01668"}
{"id":"763b23c0-b124-4c19-b7d1-375038aaa1c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91452","predicate":"biolink:affects","object":"NCBIGene:2185","sources":[{"id":"urn:uuid:72f0a998-7043-44f9-9717-06c2f875fc45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9382","original_object":"UniProtKB:Q14289"}
{"id":"9f535428-5776-4f32-b8a6-c10b8209c678","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68551","predicate":"biolink:affects","object":"NCBIGene:25711","sources":[{"id":"urn:uuid:b8a4f438-d4ff-494f-98c6-7e7bced065f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5017","original_object":"UniProtKB:P23897"}
{"id":"6c447621-d5a2-4eca-a972-9e5f58f2a342","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131180","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:8957ecbf-b91b-41a9-af77-112cd627618d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:567","original_object":"UniProtKB:P08588"}
{"id":"865547a1-5996-4cc4-9c96-b61a65fa573b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94534","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:e2116179-05f5-4459-8f3f-02ac111ab94e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:47","original_object":"UniProtKB:P28566"}
{"id":"9641d61a-a81b-496c-9979-411fe2366b5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K9C42672RH","predicate":"biolink:affects","object":"NCBIGene:4293","sources":[{"id":"urn:uuid:d7c698dd-5d65-420e-a2f7-f5701b947725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8070","original_object":"UniProtKB:P80192"}
{"id":"7a762c19-9e49-42d3-833f-5f3deb2353c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121513880","predicate":"biolink:affects","object":"NCBIGene:59341","sources":[{"id":"urn:uuid:26042b39-fde1-43be-b276-40bbf744aebe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10304","original_object":"UniProtKB:Q9HBA0"}
{"id":"01af3581-83f0-4cfe-ba86-710a7184c794","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4575","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:fd9cee0f-caa0-4378-bb48-04085a909552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1616","original_object":"UniProtKB:P41143"}
{"id":"f5caee1d-81d0-4598-a4e9-569c73297ac5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18397","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:3af75c81-244e-4c10-8d61-c4471e249626","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2144","original_object":"UniProtKB:Q923Y8"}
{"id":"5872544f-c008-4be2-bd9b-c783870a95d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:520985","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:412b5d86-ad18-4ee1-a0b8-35dbd96a6f93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7110","original_object":"UniProtKB:P28222"}
{"id":"258dc099-5505-4369-addd-32d1ca423c45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92607","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:0c66544d-c739-42d8-9a7a-8550fbab347b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:150","original_object":"UniProtKB:P08909"}
{"id":"bbe2804b-cd9d-4cb3-9e1f-db53f98604ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93363","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:10118846-7c3b-4b78-97f6-06a84dd8d665","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5509","original_object":"UniProtKB:P18825"}
{"id":"6b99b2a2-c5ae-4eec-af2d-5686508b9f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53326807","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:9c102253-b93e-4449-9a66-74769234081d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3471","original_object":"UniProtKB:P25103"}
{"id":"bb881770-f3c7-4628-9c17-d6cb7d7fde62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75377","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:8930dd87-8e8c-4735-a05d-ed8941e87ea2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2284","original_object":"UniProtKB:P46098"}
{"id":"586df1fb-7369-44d5-baab-ee062388e636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91807","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:534a487e-97aa-4385-8688-29436fe06f88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12578","original_object":"UniProtKB:P07550"}
{"id":"3e3cb520-8925-453a-9ce2-1a74a33bd739","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71956","predicate":"biolink:affects","object":"NCBIGene:3320","sources":[{"id":"urn:uuid:9857ba91-bd41-4543-b9e0-5f361e0b2d78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9827","original_object":"UniProtKB:P07900"}
{"id":"74c1c608-ed29-446b-94be-75ba2a88de6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9CD894KUMJ","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:5a550d9d-22de-4e55-9bb9-32d173d0155c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5816","original_object":"UniProtKB:P43116"}
{"id":"34c9d650-49c2-4b5e-b5d4-e857641e4639","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135755","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:454e9fd8-2606-43e0-b29a-423670dee02e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1919","original_object":"UniProtKB:P34995"}
{"id":"f292beed-aecc-4e45-ba09-53e867d7d9c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34727","predicate":"biolink:affects","object":"NCBIGene:298521","sources":[{"id":"urn:uuid:1a115c89-b133-4f50-93bb-7ac50ebe37ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4181","original_object":"UniProtKB:P42264"}
{"id":"c0218f44-2cd9-4256-9a22-ee4e98cf5356","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:653","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:519beea2-02a1-49f6-95cc-243e2c8552d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:653","original_object":"UniProtKB:P32299"}
{"id":"876cf0ac-b2fc-4234-8fba-78e0a34b47b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59896759","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:7e3bdf7f-a563-4cd4-8145-6289daa40238","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4369","original_object":"UniProtKB:P34903"}
{"id":"c55f6502-3298-4017-9c8e-6af25b95c365","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:209090","predicate":"biolink:affects","object":"NCBIGene:23581","sources":[{"id":"urn:uuid:cf368901-dafb-4005-9280-0d6d6ae1c0dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8674","original_object":"UniProtKB:P31944"}
{"id":"71d956b2-a618-4de2-ac8d-324c9b269279","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813890","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:f5da2a49-f11a-46d8-a163-a7a3be20cb35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5836","original_object":"UniProtKB:P21462"}
{"id":"0a325a7f-aef2-4846-8c05-037e11272cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:5cd84e07-586e-40b8-981e-0a1139eba2d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P35408"}
{"id":"f1de40df-18a2-4ed1-a469-b001c5415272","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2527","predicate":"biolink:affects","object":"UniProtKB:Q07652","sources":[{"id":"urn:uuid:15ead292-df2d-429b-927f-07e9a8fa9258","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2527","original_object":"UniProtKB:Q07652"}
{"id":"842c28ac-94a5-40c2-ad12-136d205cf4dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156881893","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:a871aed6-cddf-47e3-983c-c0f6e34a024e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13932","original_object":"UniProtKB:Q99808"}
{"id":"896349a3-b572-46c9-8201-c2e147f46ec6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46864270","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:0e69bf96-1376-4a09-86d6-d63dbfa9c03f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8170","original_object":"UniProtKB:P16234"}
{"id":"19f38fc9-f468-40ed-840e-c4cd21f54058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10512636","predicate":"biolink:affects","object":"NCBIGene:762","sources":[{"id":"urn:uuid:96be2278-b3b9-4e8d-a4bb-a2121c913972","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10433","original_object":"UniProtKB:P22748"}
{"id":"eda6cce1-64ba-43e4-87e0-1c51780dedc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64629","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:f4eb73e0-5075-43af-bd46-389a5970ff6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:147","original_object":"UniProtKB:P30994"}
{"id":"ce599e2a-a5d6-4ad6-a333-2eb344f985cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L4C1UY2NYH","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:65943673-b9a0-48e9-8a38-1e5ad50324f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9636","original_object":"UniProtKB:P42336"}
{"id":"c6079266-f55b-4f55-ad21-1cd4d4eecd9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:1847b3af-9e0d-46cf-8425-76806a0e4ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P28566"}
{"id":"f8697970-8c7f-4462-bcb1-a66d11cd8858","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3762","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:3f88bada-46c0-4aa8-92b7-38c9ee16d1a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3762","original_object":"UniProtKB:P25929"}
{"id":"63431411-3925-4249-98bc-1f0ed77db114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9927707","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:02c4ac5c-05cc-4b24-9f45-f54f7c11ddde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4248","original_object":"UniProtKB:P48058"}
{"id":"0c76bb42-fe5d-4a21-8e24-b7232d603338","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16659801","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:6b703c1b-6621-4e0a-ba43-09e2f53fb725","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6346","original_object":"UniProtKB:P23385"}
{"id":"70985690-c4d7-46a3-a196-17af6d8b2e87","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9596","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:a01f0f60-0652-4afd-a43d-db05a18367ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9596","original_object":"UniProtKB:P21589"}
{"id":"08704375-0d76-4d98-84b0-efc66ade1794","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11442117","predicate":"biolink:affects","object":"NCBIGene:6547","sources":[{"id":"urn:uuid:e380e7c3-e311-4da6-8eac-14ab9b9c9cc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9484","original_object":"UniProtKB:P57103"}
{"id":"abbbdd93-1213-40cb-8656-a962e519880c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946093","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:ef168c95-1fd4-4d6e-9609-b36052d17324","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10598","original_object":"UniProtKB:Q8NEB9"}
{"id":"38fc585d-4fb1-46ce-81b2-6864fa7b9776","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:18f9a760-607e-46dd-b0e8-0693717c3e27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P23415"}
{"id":"9d4e9f18-36c6-41ae-bcb3-98cefd95021b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10202471","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:fb998d84-df44-43d2-8213-b22c7e648bac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5949","original_object":"UniProtKB:Q00535"}
{"id":"e423ff02-d515-4a5e-bd1b-3d30c83aa701","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104162","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:880f2fc5-10fb-4466-aa11-8eb650a97d8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10104","original_object":"UniProtKB:P08912"}
{"id":"4bd4955b-d848-4480-8d9f-30582f61cc80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36704","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:29b79552-c60f-48a2-9de9-e48495968ce6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5003","original_object":"UniProtKB:Q9NYK1"}
{"id":"dbf0e3b9-5744-4015-8b0c-78918493b725","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44354270","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:2008c88a-690f-4764-bf8a-b081b9ae66a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2961","original_object":"UniProtKB:P04035"}
{"id":"e286ea53-b53e-4f56-819e-6b1bc3075885","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4RZD8LK83V","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:8313c4e2-a998-437a-9863-7810c586e165","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11679","original_object":"UniProtKB:Q02750"}
{"id":"53e0c4c0-197d-4852-9514-b091c936e553","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95093","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:049d6a55-af68-4d23-a89f-ee8b4c78e013","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8974","original_object":"UniProtKB:P48736"}
{"id":"8e422e1e-b27f-41e9-a618-2b08014a8520","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:104916","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:3b51efb8-2a8e-4276-ba7a-963581f02de1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4156","original_object":"UniProtKB:P34903"}
{"id":"27ca513a-5f7b-4afc-acea-ac9a5b397997","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:c99f6f58-461c-444b-b651-c7a5e22994b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P19020"}
{"id":"0ec19c2d-ea4a-463c-b7ba-96db8f447176","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N2NOA4CE04","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:7b01a97b-61cf-4d1f-aa84-c6906af67e64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4117","original_object":"UniProtKB:Q8NER1"}
{"id":"a0da8952-208f-4c8b-9079-57e2c278cb0e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7LQ52UF48A","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:899ad7c1-7920-41e9-a065-885d33ceecb2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5945","original_object":"UniProtKB:P24941"}
{"id":"1e9f2ac3-85ea-4414-9dea-034e1b0081b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817490","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:26a945e4-386a-442f-a9d3-57c1e7db1829","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6168","original_object":"UniProtKB:P52500"}
{"id":"7e15219a-1ba3-4d6a-bd99-460070799a8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817469","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:46f31370-ff3a-49bd-9bfc-a1c70a593ccf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4372","original_object":"UniProtKB:Q8WXD0"}
{"id":"d35bcd44-7c48-49f5-9c27-ab7473c8fcb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183227","predicate":"biolink:affects","object":"NCBIGene:5726","sources":[{"id":"urn:uuid:53e9fab8-2462-4b57-9561-8986aaae3edf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12495","original_object":"UniProtKB:P59533"}
{"id":"bef892e4-00d9-4af0-8b13-ee66ab0c3089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49872868","predicate":"biolink:affects","object":"NCBIGene:1559","sources":[{"id":"urn:uuid:0ae3e61b-62f1-4c5e-9f09-74e9e1e3d12d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8777","original_object":"UniProtKB:P11712"}
{"id":"df7ff541-6860-477c-9c6b-50715d2e3b8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NMZ08KM76Z","predicate":"biolink:affects","object":"NCBIGene:9971","sources":[{"id":"urn:uuid:51806fd9-4d21-4809-82b5-352d538bea18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9725","original_object":"UniProtKB:Q96RI1"}
{"id":"a635f855-f76c-463b-9132-4c32bc6c3df0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16219332","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:9af37901-abe0-4122-9ed6-59e98e27afb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:990","original_object":"UniProtKB:P25101"}
{"id":"1f790817-e446-426d-989d-fd5fe7ce295e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:41b28db3-171c-4e18-9fea-22427beab04b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P35462"}
{"id":"217b5dbf-cc72-426d-8e7d-9f0513bb1ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32087","predicate":"biolink:affects","object":"NCBIGene:14764","sources":[{"id":"urn:uuid:07aba894-4ff2-45b0-ac10-9afb3907a64e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1911","original_object":"UniProtKB:Q9Z2J6"}
{"id":"7a345f8a-c380-461c-ac3b-a9c273eae738","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:632","predicate":"biolink:affects","object":"NCBIGene:12209","sources":[{"id":"urn:uuid:f7c5a408-11e6-436a-9643-ab339275cdf5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:632","original_object":"UniProtKB:O54798"}
{"id":"2090ac98-c581-4521-bf28-a444b90fdbf1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3011","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:864d8c9d-0899-4d06-b198-66449c2d84c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6374","original_object":"UniProtKB:P12821"}
{"id":"a59f3598-1a00-4b06-8c56-8e8b39a881ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YI437801BE","predicate":"biolink:affects","object":"NCBIGene:1233","sources":[{"id":"urn:uuid:844c978b-dcc3-43fc-8495-70c36a69304f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6477","original_object":"UniProtKB:P51679"}
{"id":"d3d04ee6-20ec-4c11-83d4-aa933b928bf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XE10NJQ95M","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:b073a317-56b1-4f27-a276-0282148e31b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10645","original_object":"UniProtKB:O00763"}
{"id":"13f2e759-de84-4b49-b5e8-9c70e4bc6527","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155411202","predicate":"biolink:affects","object":"NCBIGene:23522","sources":[{"id":"urn:uuid:e03377c1-54d9-4043-aa52-5af944174109","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12938","original_object":"UniProtKB:Q8WYB5"}
{"id":"05b7248d-dcae-43dd-9970-423cdb929771","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91712","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:9bce1234-a1bc-4e63-a91e-1df1bd7d1764","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2285","original_object":"UniProtKB:P46098"}
{"id":"6a77ffe6-4d9a-4082-89fb-5f44828db1cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9067","predicate":"biolink:affects","object":"NCBIGene:4881","sources":[{"id":"urn:uuid:29a76f5a-dc6e-435d-a5f2-ac4d0008999a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9067","original_object":"UniProtKB:P16066"}
{"id":"ee7845a3-dd2e-4766-8c6a-aa714278a4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163358784","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:ebedfd72-f172-4d1a-9dcd-60db81e38a87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11993","original_object":"UniProtKB:P0DTD1"}
{"id":"9fe6ddf2-3a55-43cd-9f90-97208f9aaaaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593558","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:7c67be8f-f13f-4464-bb53-0199ec27f154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10502","original_object":"UniProtKB:Q99572"}
{"id":"e6ae4868-6394-48ba-b90a-9876b52532b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125640","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:214e4dd7-5d12-4a16-ba2e-91c61c50491a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:372","original_object":"UniProtKB:P29274"}
{"id":"b0786038-e736-452c-b659-ff0901ccc238","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3359","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:255928de-6cbf-4a39-b53a-5245e66bf07a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10600","original_object":"UniProtKB:Q6RI86"}
{"id":"a13f704f-4929-43f1-a868-9fcc41fe62cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:bb42f516-0a67-4f5b-9b6c-a30ce6d75a9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P31388"}
{"id":"f7eec507-4683-44e0-b618-6f0c64a59761","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:1e44bc72-219c-4b10-a01a-6b552d61a15f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P28335"}
{"id":"b63e6d3b-0db8-4caf-8101-18e1eab2f2c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79560","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:eaa47bac-4756-4578-b313-851ca14c95f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4210","original_object":"UniProtKB:P42263"}
{"id":"77d184db-b320-40ae-ab9a-2cdc6e9d2933","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44583582","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:d6df4821-9c99-447e-a2dd-693831c6ef09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5904","original_object":"UniProtKB:Q9H244"}
{"id":"bdc2b0ec-ed14-4f08-9b73-0ba345e880af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10344307","predicate":"biolink:affects","object":"NCBIGene:4325","sources":[{"id":"urn:uuid:f9d227a1-e075-4d25-9e1e-959d377c4c6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8629","original_object":"UniProtKB:P51512"}
{"id":"b51d925a-f6ba-4a90-8e51-f5645e3f5ad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135123","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:14410a9e-602b-4bf1-a8e6-e8cb4d6258c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:550","original_object":"UniProtKB:P07550"}
{"id":"60df9d5f-de02-4bd3-8fc3-2f00712e97d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78432","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:fd766723-cb4d-4a17-b5a1-24c0f0126d38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7397","original_object":"UniProtKB:P08069"}
{"id":"cafbece2-1689-404a-bdbe-e2f8de2cfaf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3165","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:f85a31aa-46aa-44d3-a061-e0c5e3f9aaab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:649","original_object":"UniProtKB:P32299"}
{"id":"30a65277-148a-472f-8838-34634d65bfc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72202696","predicate":"biolink:affects","object":"NCBIGene:699","sources":[{"id":"urn:uuid:ee824f03-a763-49f9-a8f7-0f5d14f4ee37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8111","original_object":"UniProtKB:O43683"}
{"id":"ae7120c5-f1e6-4a5a-bb7e-0bd4ceee924e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:6157b217-621b-4089-854e-0144ef912829","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P41595"}
{"id":"cf1214f0-7dc6-478d-8322-3929520dd106","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817437","predicate":"biolink:affects","object":"NCBIGene:24875","sources":[{"id":"urn:uuid:0b39cfde-ab59-4a01-9804-a6a8db8faf03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2268","original_object":"UniProtKB:P30083"}
{"id":"eb0d6e41-649b-4f24-8478-c82825d9a5bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:652","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:874eed4c-4a3d-4828-98f2-e1eb3c252a86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:652","original_object":"UniProtKB:P46663"}
{"id":"d55a1a6d-501e-4ea9-a24e-ddaf350b6a50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4801QYW816","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:b3bec72f-3aae-4f69-b039-b67e64a1ad67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10000","original_object":"UniProtKB:P43405"}
{"id":"a0ca712b-6a3c-4831-930e-423b34f5bf5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124203831","predicate":"biolink:affects","object":"NCBIGene:284111","sources":[{"id":"urn:uuid:aeca5833-6334-44f2-9938-db619738ec27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12850","original_object":"UniProtKB:Q86YT5"}
{"id":"950e3e3f-c33b-440e-88f0-7e9371a2c975","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:c301e644-954c-4ef5-bc5c-c6511d9f2f9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P28222"}
{"id":"dc444200-9388-4175-bacc-1735afb232ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53317992","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:0b61b179-267d-4af7-be32-7d59e3aec6dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3248","original_object":"UniProtKB:P30994"}
{"id":"29541d58-ea79-4e48-983c-957d553fc117","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O12H7VFU6P","predicate":"biolink:affects","object":"NCBIGene:1269","sources":[{"id":"urn:uuid:adce950a-42e2-42be-a3dc-c1ac00c6a3f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12751","original_object":"UniProtKB:P34972"}
{"id":"62b53724-5e9b-4313-99b4-f2afcafda733","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:75658JDG29","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:72315e17-db41-4477-af8a-621a64a989ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12720","original_object":"UniProtKB:O00329"}
{"id":"0f2fc98a-0fed-44ac-8b5e-6b4b1640e34e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16495618","predicate":"biolink:affects","object":"NCBIGene:23657","sources":[{"id":"urn:uuid:af7bd421-03d4-4cd2-bc46-2346d0d44ba5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13931","original_object":"UniProtKB:Q9UPY5"}
{"id":"5846246f-875a-4fce-8c0c-abff2792ecb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X8BW0MQ5PI","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:006df70d-635c-47a2-8199-b21fef7cb9de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11757","original_object":"UniProtKB:O60885"}
{"id":"ef27b180-db93-4153-a71f-cc959316eb5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9455","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:2a3951e2-2438-4c15-913d-4dd8eab43e92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9455","original_object":"UniProtKB:P55085"}
{"id":"2f38bf8f-b3c1-44aa-b400-205b2d5b2f05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:3763","sources":[{"id":"urn:uuid:9ef7cb16-48c7-479f-be60-1a05d707d728","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2340","original_object":"UniProtKB:P48051"}
{"id":"a784dc70-288b-4b37-9bc5-40ca1a6b6de0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71311710","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:cbf75546-3baf-4b64-9aaa-20382f95b9cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1475","original_object":"UniProtKB:Q9HB89"}
{"id":"7578e65f-67e7-4ed9-8578-51da8ee10577","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:456faa16-cbb8-4d64-89ba-c9d56b008a7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:Q9NY46"}
{"id":"89db2ff5-94e8-495f-8768-184f01917271","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92190","predicate":"biolink:affects","object":"NCBIGene:3274","sources":[{"id":"urn:uuid:c3111d31-826c-4da8-8845-466c57abcca8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3959","original_object":"UniProtKB:P25021"}
{"id":"e70e7a41-c7dc-4c53-a459-771b8a6073d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164885960","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:b1809ba2-e679-480d-95f5-3841e6b07da2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12150","original_object":"UniProtKB:P29274"}
{"id":"4f3f45ce-7000-464c-970c-69956f6a625c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37550","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:21b40d75-f62b-4597-8241-109953c287bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:911","original_object":"UniProtKB:P21453"}
{"id":"e8eaf55d-7f5a-4ec2-866d-d48ec5304f8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:25187","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:8d5f034c-9e3d-4fc0-b87f-f7a1ecff50e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2430","original_object":"UniProtKB:O75762"}
{"id":"3de8ff33-a4a2-47a3-a92f-c756d046c72f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25025654","predicate":"biolink:affects","object":"NCBIGene:260319","sources":[{"id":"urn:uuid:e0e1990c-03c3-43ff-bb14-34684e5c7d7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6189","original_object":"UniProtKB:Q8K418"}
{"id":"1b98323d-bd7a-4603-99d8-91f3dc2199c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80000","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:86c62882-65a6-47a1-91c7-10f0e1c32fbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2835","original_object":"UniProtKB:P62508"}
{"id":"5e2e9ee7-f363-4d99-b202-5c93aac4d16e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177440","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:c96072bf-e60b-4e11-97e2-959c7ce79623","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1640","original_object":"UniProtKB:P32300"}
{"id":"52c991ae-ad3b-4f94-8862-05c443ffa2ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64159","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:c4a3f502-bc6d-4060-9746-2045074200cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1426","original_object":"UniProtKB:Q14833"}
{"id":"18f6502e-6e9b-4278-8620-9f95dfaa5c26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:230a8328-6f54-49c0-bfcf-4a955a5b3849","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P28335"}
{"id":"500a91f9-9fc8-455d-a2db-f2ac499989d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61080","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:3770f7c2-bb0d-4f22-a1b3-3cf966d50409","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7006","original_object":"UniProtKB:Q8WUI4"}
{"id":"07f94448-7f14-4b2d-83c4-774548874a97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13302","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:3aa80e69-85eb-46a0-8769-d8a89bc2cbf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13302","original_object":"UniProtKB:P30530"}
{"id":"7c7bbac5-4d27-47f6-a034-58f7864ddf35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11158","predicate":"biolink:affects","object":"NCBIGene:25245","sources":[{"id":"urn:uuid:5649cec8-c7fa-4ae2-95fe-cc8af01d4052","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11158","original_object":"UniProtKB:P25023"}
{"id":"f0cf264e-690d-4192-b544-c89d77f83fbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:631c4881-fa2c-436b-8b90-68263b0db0b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:O94759"}
{"id":"4e302687-ddd8-4bf6-95ec-1cf510a98d37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:77109ff1-941f-429a-af1d-73d622fde453","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:P24941"}
{"id":"86418121-76c5-4a26-90b2-4fe1dbd13ffd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76850157","predicate":"biolink:affects","object":"NCBIGene:9312","sources":[{"id":"urn:uuid:76db507e-4bac-4ca0-8914-c273cbc6b9ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:11478","original_object":"UniProtKB:Q92953"}
{"id":"fa92410b-cd77-4333-aae9-4ad7a0631d12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1527","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:dda81d30-fa0a-465e-bea1-9a7111a1ac38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1527","original_object":"UniProtKB:P49146"}
{"id":"80f81eff-0faf-4fd4-829d-a3ad6ef20f25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165437860","predicate":"biolink:affects","object":"NCBIGene:9101","sources":[{"id":"urn:uuid:11b29ca1-9a4c-498f-b5d0-886546edc646","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12224","original_object":"UniProtKB:P40818"}
{"id":"a3d47832-a496-4ad2-9e1b-232a8c41c7de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146651362","predicate":"biolink:affects","object":"NCBIGene:79671","sources":[{"id":"urn:uuid:b4d2e896-e025-42bc-82bd-cc6a51dccc01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13384","original_object":"UniProtKB:Q86UT6"}
{"id":"defc38bc-dd06-4805-9ead-df2ba4701f16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73295","predicate":"biolink:affects","object":"NCBIGene:8001","sources":[{"id":"urn:uuid:6497163d-038f-490e-a66e-7ac49323367d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:733","original_object":"UniProtKB:O75311"}
{"id":"5e84ed62-c859-45b7-99a6-e0167284c4bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7494","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4788c6ca-8eea-4ddb-a04f-571ef81d1ad7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7247","original_object":"UniProtKB:P28223"}
{"id":"7f737877-03e0-4ce7-bf43-b5c561705ed3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:271b0e74-81f2-42ab-a912-f867c187535d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P08913"}
{"id":"d815d491-63c4-4b03-8a0e-4c171bfd75d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:681569","predicate":"biolink:affects","object":"NCBIGene:6240","sources":[{"id":"urn:uuid:58a11814-e940-44d8-851a-0b33c26dfccb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6802","original_object":"UniProtKB:P23921"}
{"id":"585afece-051b-455d-b6c3-4c2598d81fb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:6263","sources":[{"id":"urn:uuid:3c393d21-f4d4-4e01-ae32-7cc8f4f93dd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:Q15413"}
{"id":"0a3f2166-4db3-465d-80b2-b9b3947e6bbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52894","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:59a8e027-c61d-48cd-a6f8-bb3a4309984a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4607","original_object":"UniProtKB:Q7RTT9"}
{"id":"9a9ced97-391a-44b2-aacd-d0acf40756ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167600","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:6459bdc2-acbf-451f-a149-8a20e178a6c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9619","original_object":"UniProtKB:P23458"}
{"id":"953ba59d-d8ad-45b1-90a2-aa9daada4752","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63937","predicate":"biolink:affects","object":"NCBIGene:146","sources":[{"id":"urn:uuid:9c0e9f42-9005-4d01-8731-49ebb920737e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:486","original_object":"UniProtKB:P25100"}
{"id":"1c96bc2f-ba15-41c0-a8b3-bb263aba331f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:108599","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:9176a384-cf48-478e-8b81-25919798de6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3","original_object":"UniProtKB:P28566"}
{"id":"7ad86487-407b-471a-87b8-3dc65f5d4a76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137213562","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:8d226bc5-209d-467e-a26d-2437999d687e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10676","original_object":"UniProtKB:Q9UGN5"}
{"id":"03969875-4d1c-4efc-9a49-782cc67b5342","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z5MR2Y1IJJ","predicate":"biolink:affects","object":"NCBIGene:6524","sources":[{"id":"urn:uuid:8b771604-b130-48f2-88ef-7ca321a678f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11905","original_object":"UniProtKB:P31639"}
{"id":"79f2dea3-df90-47d4-a670-853541a9f89e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321152","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:950f0849-e15f-46db-a5ca-3ed30d81e0f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10139","original_object":"UniProtKB:P40763"}
{"id":"0a48ca95-5648-4231-aee4-04cb121c2fdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94186","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:8e8c7500-4e08-4e76-b889-b415e0bfb892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9702","original_object":"UniProtKB:Q13547"}
{"id":"fb46992e-e99b-4ad1-90ff-e5d6f5a3485d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LFR1253W75","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:84e7f5f3-bbdc-4ebc-be52-d095cb2f9866","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5946","original_object":"UniProtKB:P17948"}
{"id":"5a9e69d3-2c72-4e35-8136-197eeea58a03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LPU25F15UQ","predicate":"biolink:affects","object":"NCBIGene:177","sources":[{"id":"urn:uuid:ddb2139f-fb04-4d40-a53e-7843623248e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8317","original_object":"UniProtKB:Q15109"}
{"id":"84ac34df-1e18-4d84-a68f-17aaa519557c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131698387","predicate":"biolink:affects","object":"NCBIGene:5315","sources":[{"id":"urn:uuid:d9519aa3-0547-440a-87ce-77378f630ea9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13523","original_object":"UniProtKB:P14618"}
{"id":"5f029f93-023d-4cc1-ad4e-8b98860ca8db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85010","predicate":"biolink:affects","object":"NCBIGene:4352","sources":[{"id":"urn:uuid:f264f4a4-4b59-4e68-8dea-a7434edb7a4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6961","original_object":"UniProtKB:P40238"}
{"id":"838499cd-f9fc-4a3f-b8a7-de8bad1f70d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841284","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:b0586f43-f1da-46b7-974d-7d5df560c2f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:423","original_object":"UniProtKB:P29275"}
{"id":"841fa353-4fdd-487d-b19f-ea50605dd9bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16000100","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:c4ef035c-4783-4b6f-84bb-d0a80b09f6f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6421","original_object":"UniProtKB:P31424"}
{"id":"3550014a-5a9d-4071-b5e0-8f1920acaab2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EOB0N7BOY4","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:b8a5acac-0be4-452d-98f5-2b6ece0a01d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13215","original_object":"UniProtKB:Q86V86"}
{"id":"739da43d-4d51-4d71-89a6-6f81374524ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10685","predicate":"biolink:affects","object":"NCBIGene:9340","sources":[{"id":"urn:uuid:a47253c4-d4d5-4d74-9703-fe499db58663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10685","original_object":"UniProtKB:O95838"}
{"id":"354b5315-ebea-4945-b7df-1d56ce085bbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5720","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:08e7d96b-2a6d-4947-944f-26cdd35e9bbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:324","original_object":"UniProtKB:P08912"}
{"id":"a922b691-2ea3-425f-834b-6bb266f59faa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50662","predicate":"biolink:affects","object":"NCBIGene:4322","sources":[{"id":"urn:uuid:0cbdad48-ba43-44c2-b675-8ee415e2fe6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5220","original_object":"UniProtKB:P45452"}
{"id":"68d4d65d-7e6a-48e9-b809-5ae3170196e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:f5cfaf8e-e4bf-4124-8ea0-ffcb088cfc4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1974","original_object":"UniProtKB:P21731"}
{"id":"5eddedd7-f254-477b-9b38-dcea42c9154b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11750118","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:8360fc79-8763-43c0-85d3-d2c839cb1702","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9253","original_object":"UniProtKB:P23219"}
{"id":"c5a5e6ec-9c23-4f1b-a404-eb2c7877fdf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47943","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:f64afef1-7c75-43ec-9562-94154622927a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4133","original_object":"UniProtKB:P42263"}
{"id":"e9e2e811-a3ea-4138-b1b9-5b760142c83f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:1d98f28c-b0e6-4e0d-ad6e-88eb9b46e634","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:Q62928"}
{"id":"36d00907-5e48-4168-ade9-766df0883f1e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1529","predicate":"biolink:affects","object":"UniProtKB:P50391","sources":[{"id":"urn:uuid:e8ed25d6-c7ca-4143-9433-f5474f74f663","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1529","original_object":"UniProtKB:P50391"}
{"id":"1e2be137-bda7-428c-9070-e0b7d8f8a89f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3742","sources":[{"id":"urn:uuid:02db235e-5ff5-4226-b0c2-57eb16a3d17f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:P17658"}
{"id":"bfb997ab-a65f-4727-a29e-ab95ef5ff80c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63587","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:9ea805ae-c3db-42da-a8b1-dc70a8c0f157","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6813","original_object":"UniProtKB:P07437"}
{"id":"14765b85-9af4-4f8e-b483-69c77980c2c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91362","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:36f58c6e-c7f6-4710-b970-5452119e583b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8358","original_object":"UniProtKB:Q96GD4"}
{"id":"0acf4a74-78f0-47da-b1cb-7d686eed0463","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8772","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:0aa663af-88ae-4f62-88a2-98297612ba71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2820","original_object":"UniProtKB:P03372"}
{"id":"c119e989-869e-454b-839d-333954b46b9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74766530","predicate":"biolink:affects","object":"NCBIGene:23387","sources":[{"id":"urn:uuid:36d96b8f-be7f-44de-842c-8ea6430ca41f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9581","original_object":"UniProtKB:Q9Y2K2"}
{"id":"42c5802a-85bf-44fe-ad90-a3d1ff5b9e33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3972","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:3fbebc12-1288-48d4-aa66-7d41329f7ee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3972","original_object":"UniProtKB:Q9UGM1"}
{"id":"1d085c8b-6511-480a-afd4-f129051bad7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817413","predicate":"biolink:affects","object":"NCBIGene:10316","sources":[{"id":"urn:uuid:b50dfb91-3f07-40f5-b769-8848c8b2a053","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1474","original_object":"UniProtKB:Q9HB89"}
{"id":"fab450e1-7ece-44a6-ab42-e1217cef1b1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41321","predicate":"biolink:affects","object":"NCBIGene:6095","sources":[{"id":"urn:uuid:726cf51f-c56e-45ce-b8df-776d40653f5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2738","original_object":"UniProtKB:P35398"}
{"id":"151c65e1-9551-4fc4-a060-6a5d10f59325","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50885","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:f0f7c515-73a7-4876-819e-86007f8c3ca0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2873","original_object":"UniProtKB:P08235"}
{"id":"e48663a7-f04b-4d42-936d-661b54d6571c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5263","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4fa8c086-d263-4502-a7a6-374cef644aa4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:402","original_object":"UniProtKB:P0DMS8"}
{"id":"f5140e4d-0f69-4219-be20-78eeeedcbb80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ENZ75DG2Z6","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:20579e19-6959-433b-a4c7-0e89fc9b3f99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10690","original_object":"UniProtKB:P21554"}
{"id":"cb87fb17-9d4e-4c30-8f72-a758352888c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1805","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:797b530e-2f7e-48c3-9298-09be7c757114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1805","original_object":"UniProtKB:P25961"}
{"id":"7c5e08d9-d2ce-43fa-aa19-397b62a422bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9577","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:21573497-4071-4b3f-9779-c2bf2a5e83de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5344","original_object":"UniProtKB:Q9NYV8"}
{"id":"858430cd-55d8-4471-b39a-cbbf7feb7cd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321149","predicate":"biolink:affects","object":"NCBIGene:5789","sources":[{"id":"urn:uuid:94dd1168-3792-4345-8725-b233b05e8e7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10109","original_object":"UniProtKB:P23468"}
{"id":"8ce97e18-4267-4716-85cd-09923bdf9075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231613","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:053dc469-33ff-44ac-b151-2bff2884542a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10029","original_object":"UniProtKB:P21554"}
{"id":"15eb6441-e96e-4fcd-902e-1f522ef9a2be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7C00L34NB9","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:97e9fac7-0287-4467-949c-a1ba93295d1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11137","original_object":"UniProtKB:P37231"}
{"id":"f33af42e-b440-40e1-8223-ed19ed411386","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G6GSO9SDNJ","predicate":"biolink:affects","object":"NCBIGene:5143","sources":[{"id":"urn:uuid:8f6f1821-bad2-40b2-9739-69b341ddb1eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9852","original_object":"UniProtKB:Q08493"}
{"id":"bbe8098d-e268-4206-9f5f-d1da5c561f45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6690","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:231b1d37-2a9d-4ce1-93c0-507dbbb1b253","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2402","original_object":"UniProtKB:Q9HCF6"}
{"id":"d089d2fe-6f28-45da-95ef-1fd03c4f43cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1661","predicate":"biolink:affects","object":"NCBIGene:18387","sources":[{"id":"urn:uuid:b3f4aaad-c919-4aca-a37d-50a279d718a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1661","original_object":"UniProtKB:P33534"}
{"id":"5735f03c-2d76-4ce4-8b79-1befee68b040","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53380803","predicate":"biolink:affects","object":"NCBIGene:8989","sources":[{"id":"urn:uuid:57d06c11-d339-4ccd-8b7f-a165edce3dbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6309","original_object":"UniProtKB:O75762"}
{"id":"b72497f3-eedc-43f6-96bc-9ef91d39d87a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64069","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c55192dc-86a9-46ce-8770-9379de041eb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:130","original_object":"UniProtKB:P28221"}
{"id":"5d2abd76-a2f2-4fe3-814b-c91c9ab1968b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64060","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:d5dbce9f-024c-43f1-9705-88eb2b1bc1dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10","original_object":"UniProtKB:P41595"}
{"id":"b184cc2c-fef6-4de4-b7a7-65a06957daf7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7936","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:475fcb0d-95a9-4008-80b7-3a743cce5d96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4790","original_object":"UniProtKB:P31645"}
{"id":"19e8ee23-a997-4b5d-9a1e-1049a0cdae24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75393","predicate":"biolink:affects","object":"NCBIGene:5586","sources":[{"id":"urn:uuid:cb6db44a-849a-43fe-bc21-f251659b80ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5290","original_object":"UniProtKB:Q16513"}
{"id":"fc3b8444-3781-4f8d-9b30-9c5c1d1e2d5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10468943","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:1723a037-85e1-4e08-a1e2-eecc6f3d7c0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6990","original_object":"UniProtKB:Q9JL06"}
{"id":"2c8a133d-0ad9-4ea2-b993-70971dc31453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6073","predicate":"biolink:affects","object":"UniProtKB:Q9JIS7","sources":[{"id":"urn:uuid:5f8c3b43-1751-4b85-af7b-7e73276ce509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4488","original_object":"UniProtKB:Q9JIS7"}
{"id":"8df28981-5d90-49ee-a0e3-915b84601b86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O4BT6C02M2","predicate":"biolink:affects","object":"NCBIGene:5698","sources":[{"id":"urn:uuid:013e513d-eebe-435c-afef-96ed860e4804","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10409","original_object":"UniProtKB:P28065"}
{"id":"5b2ad8e0-ced6-4872-9c3e-0e08719864e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6120","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:091ba7d9-5c52-44dc-b208-6959ce54b32c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6120","original_object":"UniProtKB:O08726"}
{"id":"845e842e-a064-4e75-89d0-84f82e3e2402","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53340664","predicate":"biolink:affects","object":"NCBIGene:5871","sources":[{"id":"urn:uuid:4f2dc1eb-ca2d-4638-8187-52065acd3fbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8074","original_object":"UniProtKB:Q12851"}
{"id":"21bb87ae-31d1-4fc0-b8d6-431f52bb87e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47612","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:638699d0-6aca-4169-b88a-7497cf4a59d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2668","original_object":"UniProtKB:Q07869"}
{"id":"ada71648-d121-4f93-99f1-c7e8b549147f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13404","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:14625022-82ca-47c5-993f-4f497bec0405","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13404","original_object":"UniProtKB:Q16769"}
{"id":"b16e3dff-0b3e-4b21-b4f2-db03c358dda3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3803","predicate":"biolink:affects","object":"NCBIGene:229214","sources":[{"id":"urn:uuid:4562d003-6026-4de4-b91e-46baf43f8f82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3803","original_object":"UniProtKB:P83861"}
{"id":"988a1489-dd2c-45ab-94e3-fd9f5fb395a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177616","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:d123a30a-5892-4a9f-898b-7c2e523f1891","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2488","original_object":"UniProtKB:Q8NER1"}
{"id":"235629c1-38e4-45fd-bee6-f161cc8308be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8359","predicate":"biolink:affects","object":"NCBIGene:219931","sources":[{"id":"urn:uuid:73fe2eff-41ff-4c67-9724-0171718d826a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11857","original_object":"UniProtKB:Q8NHX9"}
{"id":"8fa87737-0293-4d80-8167-c62d5a0ddfec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:b4918723-2634-470e-9feb-813323d272e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P50406"}
{"id":"078ee7dd-7510-4dfb-8955-5670b8592fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6604863","predicate":"biolink:affects","object":"NCBIGene:3784","sources":[{"id":"urn:uuid:a0b24fc1-287e-4f22-a775-74dd30e83c8e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8610","original_object":"UniProtKB:P51787"}
{"id":"fe7379b7-9ab6-435d-9d0d-aeb0d0a5bbb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311029","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:99b18d31-c4d1-4c42-b703-6cc215dacc1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:234","original_object":"UniProtKB:P97288"}
{"id":"b9c8a7a0-be35-40ab-9b9e-e63ee698d56f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49822115","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:725bff20-7949-44b1-bcdf-f301a5924879","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8947","original_object":"UniProtKB:Q14416"}
{"id":"d236cdf4-2f73-44dd-b28d-c3fbbc338cf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2062","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:fd83d1ca-f10c-4ad9-9fae-9506db263250","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2062","original_object":"UniProtKB:O08858"}
{"id":"6cd9a1ef-9991-47a9-ae64-1bf345d329b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11601743","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:d1278cce-f5cf-4ea0-8fe1-4872e54cd088","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5971","original_object":"UniProtKB:P09619"}
{"id":"42dddec6-28ad-4f5b-8212-651311f9faac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2008","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:12673b31-0a17-4378-b6ed-de2c6c50d773","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2008","original_object":"UniProtKB:P35346"}
{"id":"2c723c86-8f94-4e10-877d-b414cd354e60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8058","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:fd8bf608-1ad0-442d-ad39-f5e9ebbb732c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4282","original_object":"UniProtKB:Q13224"}
{"id":"2a6271e4-308f-485f-a7da-7c90ec2f6951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4740","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:ed232356-18dd-4d81-a50a-1322f4efce34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:345","original_object":"UniProtKB:P08173"}
{"id":"3f0120d3-b0b1-4e6e-866a-9999cc8af243","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63453","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:87ee005f-ff10-4576-b6f6-04782b3c46af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7707","original_object":"UniProtKB:P22455"}
{"id":"92db2431-651b-41b3-86a4-0556796da7d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91351","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:2568f2e4-858f-4e86-8465-67cba679897d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8204","original_object":"UniProtKB:Q9Y243"}
{"id":"4b4f4af7-b348-45e3-b4f4-f1b5b6eec148","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7763","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:8dc4aa86-b195-4949-90b8-8ec6308644b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7763","original_object":"UniProtKB:P30874"}
{"id":"5f1bcd16-3a27-4eef-bdc8-5c46c3b307a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75401","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:1bdd02e9-032f-48ee-a762-451a155da980","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2","original_object":"UniProtKB:P21917"}
{"id":"4d6edf6f-76fc-4bf9-b4f7-8f27704840fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:d6cde310-365c-4075-9bc0-56e9be99dca3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P35968"}
{"id":"b33ba924-a80d-450b-a2c3-d48143b7f2df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10124389","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:5e46554a-6b7e-4774-85d3-16660c849b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2175","original_object":"UniProtKB:P30518"}
{"id":"ed851530-0d11-493d-8354-2431caba34ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993635","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:1ffdc4dd-6005-4181-b14b-e686acc3806a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12334","original_object":"UniProtKB:P53779"}
{"id":"1b8192ca-8ebe-490c-b3a6-de9f333abd8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138674003","predicate":"biolink:affects","object":"NCBIGene:1503","sources":[{"id":"urn:uuid:4a5b4d0a-1198-4d31-b33e-7bc2a034c9ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12314","original_object":"UniProtKB:P17812"}
{"id":"bee82546-a79c-408e-b8d5-3d391b15dd0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8364","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:6f5b452c-9620-4b36-ae58-7ccc24a8e3ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:503","original_object":"UniProtKB:P35348"}
{"id":"3c2a3f06-3af0-4c21-831d-8b03f3baa0b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817429","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:1136521f-64cd-4cd6-b922-ec926bd16e97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1814","original_object":"UniProtKB:Q03431"}
{"id":"62e44f8d-c60c-45c2-9b1c-8c494a6b014b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16827","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:0e1f6476-c1f8-413b-8058-46d98ec40d50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2869","original_object":"UniProtKB:P08235"}
{"id":"911174df-b0e1-4ba0-858f-5ded66852311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311293","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:8a640286-5913-4c5e-a54c-fd76febcc431","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1229","original_object":"UniProtKB:Q9QYN8"}
{"id":"f0b354be-d09a-49a0-9b4b-c656d3853b71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35056","predicate":"biolink:affects","object":"UniProtKB:Q9JJX6","sources":[{"id":"urn:uuid:db29d8fc-6103-4b89-917a-cc3f71f4dfe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4093","original_object":"UniProtKB:Q9JJX6"}
{"id":"f844029f-4089-4b56-b1ce-4713e6c7ff78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1004","predicate":"biolink:affects","object":"NCBIGene:50672","sources":[{"id":"urn:uuid:a264dcc0-16ff-454b-a094-ca6417b01444","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1004","original_object":"UniProtKB:P21451"}
{"id":"690914ad-b359-41a6-abbb-8df68ca34018","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:45c67fa7-5168-4ef4-a926-47d88c0b9558","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P29275"}
{"id":"740c1bc4-4f2d-48a4-ab62-b72ee43c30ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53869679","predicate":"biolink:affects","object":"NCBIGene:5740","sources":[{"id":"urn:uuid:9261f696-63ba-470f-8e69-554bce56aacf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8795","original_object":"UniProtKB:Q16647"}
{"id":"31283247-f8ae-4adc-906e-766e0c3fa68b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:127757","predicate":"biolink:affects","object":"NCBIGene:18754","sources":[{"id":"urn:uuid:4b2f434e-e76d-45bf-b31d-c303d9a77d4c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6034","original_object":"UniProtKB:P16054"}
{"id":"64d4e4bb-6839-41a9-ab43-910d676c6fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1808","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:7170bd46-d141-4fcb-a860-10840b99c8ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1808","original_object":"UniProtKB:Q03431"}
{"id":"1e7603f7-5de9-4ede-b9ff-620e850dc227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75261","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:b7b16489-2515-42c6-9d3e-5075f4ec056d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2646","original_object":"UniProtKB:P10276"}
{"id":"b231c53f-25ae-4401-a842-7da4935b0e32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947048","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:11792815-f21d-4ee0-a88e-7fa2045e20f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3122","original_object":"UniProtKB:P37268"}
{"id":"edf32a2e-e119-4855-8ed4-ef56600573a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64122","predicate":"biolink:affects","object":"NCBIGene:24318","sources":[{"id":"urn:uuid:af07e266-401d-4010-a673-831cb7f036c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:960","original_object":"UniProtKB:P61169"}
{"id":"835aec9d-0cb2-419c-bdd8-22868982aae8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2609","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:bc4dba5f-7b24-4167-a377-e67f806ae325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2609","original_object":"UniProtKB:Q12809"}
{"id":"8a8d2320-fd3c-4c30-9d00-0465de31cec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:124125214","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:2a60be50-1a0d-4652-9b62-6e8f09f6a50a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12567","original_object":"UniProtKB:Q99571"}
{"id":"9c626986-e64f-4dad-81e6-754a62e2b43d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6073","predicate":"biolink:affects","object":"NCBIGene:12288","sources":[{"id":"urn:uuid:bada5ca0-df6e-448f-bcbe-6685f43faf76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4488","original_object":"UniProtKB:Q01815"}
{"id":"80b6b213-af20-4bf4-bf21-67c66c48c842","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:912","predicate":"biolink:affects","object":"NCBIGene:1395","sources":[{"id":"urn:uuid:9032812b-89b9-4d6d-a169-faf44bd3852d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:912","original_object":"UniProtKB:Q13324"}
{"id":"84450b6a-bf94-46ec-8aa5-a81d2a0e10ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:298521","sources":[{"id":"urn:uuid:0f96f807-c837-4ea9-a222-0b14579fa6a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4317","original_object":"UniProtKB:P42264"}
{"id":"ee6fac1f-be27-4076-947c-410f620e6750","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:4fa8cd06-2298-4c45-bd3d-54f8f88034d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:Q16445"}
{"id":"3e4e8359-1696-4d82-bd50-0dde419429d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44450494","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:ee78bf8d-ffe4-43ff-89f7-c44774c58374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1880","original_object":"UniProtKB:Q13258"}
{"id":"164b3ad1-f7ae-4e3d-a4a1-761c4c09c678","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40083","predicate":"biolink:affects","object":"NCBIGene:6868","sources":[{"id":"urn:uuid:6fb17e0e-3ff7-4e68-a651-8b85db883ecb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8680","original_object":"UniProtKB:P78536"}
{"id":"a87732f4-87e8-4b62-910e-62de9e1eddbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J57O328W4W","predicate":"biolink:affects","object":"NCBIGene:3778","sources":[{"id":"urn:uuid:a1490119-6a13-4387-929b-47673eb76b83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2307","original_object":"UniProtKB:Q12791"}
{"id":"3d4135fa-80b9-400f-9622-3988310b5c11","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95059","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:cec56e96-8264-4f68-a1b0-03e846d5c0ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9405","original_object":"UniProtKB:P24941"}
{"id":"36cec69d-d6e9-4cb6-99c8-17b21da0a280","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CWG62Q1VTB","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:ead578fc-0128-47fd-abf0-a4cfbc76bb97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9920","original_object":"UniProtKB:P04629"}
{"id":"09eaf61d-4eb4-4049-83f7-96e20362a5ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71452040","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:f6db851a-18a0-44db-abeb-6903ca813513","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9190","original_object":"UniProtKB:P35372"}
{"id":"4e9fe6ba-f50b-4afa-99c2-31429b543ed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49868","predicate":"biolink:affects","object":"NCBIGene:1263","sources":[{"id":"urn:uuid:18f2fced-1e64-4da4-b447-1605814bdf0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5666","original_object":"UniProtKB:Q9H4B4"}
{"id":"c753dbb1-f32e-4bbe-9e0e-1776e2e1d5c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N488540F94","predicate":"biolink:affects","object":"NCBIGene:5243","sources":[{"id":"urn:uuid:624c23b4-23af-4d7d-aa77-ede206db88ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13578","original_object":"UniProtKB:P08183"}
{"id":"57c6735b-9400-4935-9a0a-456b3d4aa9ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4C4P7L0W63","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:f7b823d8-6679-4daa-9cfd-6bdbc1f0978c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1420","original_object":"UniProtKB:P31424"}
{"id":"5128e0be-5fbd-4194-8a9d-444842bed0c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117072556","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:e2d82bb9-7037-4197-8c0b-dae257660c08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8999","original_object":"UniProtKB:O00519"}
{"id":"47baa4ee-a535-4ce6-954b-dd1647746428","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3BY9Z3M34G","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:c8d8b0eb-fbb1-4bbf-8dd7-ef97511067c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10744","original_object":"UniProtKB:P23458"}
{"id":"fb1f691e-0ab5-4a15-993a-66ec2ffa2eab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6442223","predicate":"biolink:affects","object":"NCBIGene:6257","sources":[{"id":"urn:uuid:646921cf-8c14-4666-802b-a9c050795b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2814","original_object":"UniProtKB:P28702"}
{"id":"3c707303-3179-4e07-bcdc-e9a1c1626b9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231364","predicate":"biolink:affects","object":"NCBIGene:1025","sources":[{"id":"urn:uuid:a0e7de3e-3401-4482-b851-050aaae496e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7934","original_object":"UniProtKB:P50750"}
{"id":"6dae0c72-464c-45e1-ab99-46abab8719f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136034","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:21fcfeb2-e354-449b-ab2c-b09b2af187ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1324","original_object":"UniProtKB:P41968"}
{"id":"e94ca95e-c5d5-421f-aa41-d94869c162b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:43J9Q56T3W","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:17715148-c1a6-44b2-80b7-fba32578b286","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8969","original_object":"UniProtKB:P42345"}
{"id":"58d9ed7e-caf1-4607-887f-c473bc622e75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2012","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:765f30aa-d9fd-4ebe-adef-ffa9d56b378f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2012","original_object":"UniProtKB:P30872"}
{"id":"4e453ecf-6a5a-46ec-8f42-302c16256bdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:832","predicate":"biolink:affects","object":"NCBIGene:12765","sources":[{"id":"urn:uuid:27c9b3bb-95be-42ad-bb23-f5c126a776ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:832","original_object":"UniProtKB:P35343"}
{"id":"1e954300-62bd-4a5f-ac0b-206b9e36bf61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:643961","predicate":"biolink:affects","object":"NCBIGene:53373","sources":[{"id":"urn:uuid:df73ee98-e3c5-4d36-9f71-b28454538a74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2794","original_object":"UniProtKB:Q9ULQ1"}
{"id":"e86cffd0-9397-4283-8c10-ad782374397f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:14533720","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:074d780f-2c21-42c1-81d2-749a46a6f1ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6","original_object":"UniProtKB:P28222"}
{"id":"feb9ac90-24fe-4e8a-9979-0bc88324b721","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9G3DCA3958","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:0428ca26-4029-48d6-8e3a-848cc3a28291","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2775","original_object":"UniProtKB:P11473"}
{"id":"3d92a638-3da9-481a-aff1-bf335a272fdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28241","predicate":"biolink:affects","object":"NCBIGene:10846","sources":[{"id":"urn:uuid:8d5cb3be-9b3d-44b3-9e88-1d55eeffd392","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13147","original_object":"UniProtKB:Q9Y233"}
{"id":"63561f82-8232-40fa-93be-a192dbc06ecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:eee1cf19-a57d-4bf4-b70d-91b68c837651","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q923J1"}
{"id":"53fd2706-bef6-422e-925d-c3a8adf67906","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92159","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:863e22b3-486d-495b-8ba3-76c5445c13dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3229","original_object":"UniProtKB:P14842"}
{"id":"fa8ad367-d633-42c5-9f2a-b3f11c25de38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44275353","predicate":"biolink:affects","object":"NCBIGene:81681","sources":[{"id":"urn:uuid:e573bb4c-79d3-4829-9924-2f2c090915d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6708","original_object":"UniProtKB:P48450"}
{"id":"1f1857ec-bb6e-4454-be07-d4d0ed39f051","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:14D65TV20J","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:1d84dbbf-e8bf-442c-aeb1-aac0f4d4646e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8863","original_object":"UniProtKB:Q96GD4"}
{"id":"d4115928-b8ac-44dc-800f-435558d63441","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:39611bdf-e6b4-4cf3-a036-8428c90c1090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:Q62928"}
{"id":"0ccc4cc7-9a0b-40bb-b4ba-238cd80f1a81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:bdf8e41e-814d-4e39-b730-4a3fda907b43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:P46098"}
{"id":"180389f9-6f77-4b8e-9b7c-31f5394591b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:345354O7AT","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:20f9c951-d52d-4610-9212-4c2f6b707b9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5727","original_object":"UniProtKB:Q8TDV5"}
{"id":"7d17e97c-29ca-4db2-900d-e5a532847011","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:35ee22a6-248c-4e72-922f-1f081c5ae724","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q13547"}
{"id":"695f9b2f-7ab9-41ed-85a6-c7ed6f93ea84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q56UE7E40Y","predicate":"biolink:affects","object":"NCBIGene:80332","sources":[{"id":"urn:uuid:e8cafd3b-7473-4371-8730-385467d2d17d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8679","original_object":"UniProtKB:Q9BZ11"}
{"id":"202fc3d2-acd9-4440-927c-6472675d3726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1028","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:bd326267-5636-4930-99d3-38f8ed9afde8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1028","original_object":"UniProtKB:P21462"}
{"id":"131c7890-b789-4bf9-8d66-c89bd6526315","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4312","predicate":"biolink:affects","object":"NCBIGene:22992","sources":[{"id":"urn:uuid:6b8ebc1a-e3ad-47b1-8630-83db72191949","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7025","original_object":"UniProtKB:Q9Y2K7"}
{"id":"7653e2ed-7d34-4f59-acbc-3d7360960f92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O5ZD2TU2B7","predicate":"biolink:affects","object":"NCBIGene:3818","sources":[{"id":"urn:uuid:057791cf-8de2-489a-9609-324fda533c5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11947","original_object":"UniProtKB:P03952"}
{"id":"85ea7521-09dd-467c-827a-446d75b90b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25125014","predicate":"biolink:affects","object":"NCBIGene:225689","sources":[{"id":"urn:uuid:09f43bd7-19d9-4dce-a16e-3cc98bacf0a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8176","original_object":"UniProtKB:Q8TD08"}
{"id":"23b654a9-2ed2-472e-a1ba-0e468b131161","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34025","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:e7e03460-47bb-4323-9df5-da92e0a225e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2827","original_object":"UniProtKB:Q92731"}
{"id":"41149dcc-98d6-4f53-9823-7d702bcbd797","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5421689","predicate":"biolink:affects","object":"NCBIGene:868","sources":[{"id":"urn:uuid:9015c808-a6ff-4880-bfe5-29ded23eeee6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12694","original_object":"UniProtKB:Q13191"}
{"id":"82465924-8e9a-456c-9a2b-e29824141fc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:205919","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:67e09a80-7372-4ddc-8f76-a78ae2df8792","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7062","original_object":"UniProtKB:P04150"}
{"id":"0a1e7018-e5e9-4616-aaca-aa32dbc59088","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O3MNS8782H","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:fe485da2-8c39-447f-a26c-cf4620f8caca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9698","original_object":"UniProtKB:Q05397"}
{"id":"eddee1d3-95f3-4a82-803e-62b293ab437d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:211468","sources":[{"id":"urn:uuid:6ea7545f-c0fa-4cfb-8f55-173a879fb707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:566","original_object":"UniProtKB:P59111"}
{"id":"55546fe1-180d-4fc2-bb12-7d5742485e13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321167","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:5319d920-13bb-4cc8-a7c6-9d75933bf316","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10194","original_object":"UniProtKB:P00533"}
{"id":"f367bac1-52f7-4ed6-81b8-0488d00fd8b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2022","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:483cd14b-6150-4236-a7d0-802acb306f4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2022","original_object":"UniProtKB:P30872"}
{"id":"2fb3a6a0-f599-431a-9980-b4989d26429e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:b6244458-4b42-4fc6-a17e-3e23d3536f1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:Q14833"}
{"id":"391e7957-0039-42ed-af45-fecce4e42d31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:41550022","predicate":"biolink:affects","object":"NCBIGene:8324","sources":[{"id":"urn:uuid:5bf7394d-794d-414b-9967-5f3781acbc7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10323","original_object":"UniProtKB:O75084"}
{"id":"3e37988c-a3df-4e0d-a3a2-91c6290487f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41872","predicate":"biolink:affects","object":"NCBIGene:1260","sources":[{"id":"urn:uuid:c62bdc7e-f659-435b-8e36-3389e604a5f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2313","original_object":"UniProtKB:Q16280"}
{"id":"88f42095-ff3c-4025-a465-48c28fe2a201","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:05b46a87-b50c-4416-816d-a6a4523492c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:Q9ERC0"}
{"id":"356dfbe3-9663-42f9-876d-95eb56ea38ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130360508","predicate":"biolink:affects","object":"NCBIGene:1579","sources":[{"id":"urn:uuid:0d11b848-f7b9-4fee-bbb9-01ed2811b30a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12767","original_object":"UniProtKB:Q02928"}
{"id":"f63492e0-8109-4be1-935c-1acdf1e4ec2c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:7326d3d1-545a-4e61-b1ac-8500b0ce5400","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P35346"}
{"id":"06d56782-a488-4579-b538-018ca404a1b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9510","predicate":"biolink:affects","object":"NCBIGene:4318","sources":[{"id":"urn:uuid:77e4ac24-8ee8-45f1-ae70-65a06a1c4f92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9510","original_object":"UniProtKB:P14780"}
{"id":"4aa39fb9-41e7-42c2-9f4f-035a0701030b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:ed936859-92be-4a75-8945-cddd5f7c5cf8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P11362"}
{"id":"c4d0ee81-405a-4339-b0dd-5a3a46128261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3789","predicate":"biolink:affects","object":"NCBIGene:51289","sources":[{"id":"urn:uuid:08e87126-0e10-4691-b64d-c96ac4cf2527","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3789","original_object":"UniProtKB:Q9NSD7"}
{"id":"81028d60-0ebe-4c68-9422-3e8b1852161e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11374217","predicate":"biolink:affects","object":"NCBIGene:319239","sources":[{"id":"urn:uuid:babb6f04-2d7e-44e3-a141-f381999ad742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5813","original_object":"UniProtKB:Q8BZP8"}
{"id":"1fb56d9e-4d3d-48a3-8bec-7dee90865835","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177579","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:13da3966-afda-4388-9dd7-a36d33687197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:270","original_object":"UniProtKB:P31388"}
{"id":"696d7d88-af1c-4e31-9662-701491e344e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122260","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:46345634-2878-41be-bda7-37dc59442277","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1644","original_object":"UniProtKB:P41145"}
{"id":"00e353cf-99e5-4336-978d-63f616899fdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2366","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:c2bd21fe-3b42-4bef-88ae-cca12b5efdda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12458","original_object":"UniProtKB:P59540"}
{"id":"10167c42-b42d-4859-bc61-de4d73da1c47","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11918","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:4d3b7b36-ea8a-44d5-9f14-3936da2e8442","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11918","original_object":"UniProtKB:Q8TDU9"}
{"id":"bc10b92e-4d53-43a8-b510-d2b018bbbd9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77363","predicate":"biolink:affects","object":"NCBIGene:1636","sources":[{"id":"urn:uuid:99760351-f972-4b3e-904b-e9672f63c0e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6344","original_object":"UniProtKB:P12821"}
{"id":"504e9d9d-18ca-467c-a6ac-add3f056bf08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817422","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:7491134f-3e32-4db8-844d-542cdc04b804","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1549","original_object":"UniProtKB:Q15761"}
{"id":"14fb75e2-83ef-48a1-84e5-a9ca3830f562","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:919","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:b09c13b7-4765-4fe8-9206-48762853ce0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:919","original_object":"UniProtKB:P47866"}
{"id":"ea919bcf-16dd-427b-bbf5-2c5a7eab1c3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2008","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:262e8b82-f809-4f18-8534-42a0ac0f2b1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2008","original_object":"UniProtKB:P30874"}
{"id":"53a13d7f-fe36-4458-8e99-de4c74d8abe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:142497307","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:74b41a7d-a250-45ae-967d-1530940f6498","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12952","original_object":"UniProtKB:P00533"}
{"id":"4f05eef5-bf61-414e-a0af-ff2f1046128c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9864550","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:279ea9ab-8acd-4249-9fac-5ff34abb6901","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4332","original_object":"UniProtKB:Q14957"}
{"id":"4c5a1f9f-ea34-43d7-85b9-54a84bbf06b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36511","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:2567f9bd-4b07-45d7-870e-778edbde1385","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4177","original_object":"UniProtKB:Q5XXA6"}
{"id":"df6c3872-9d47-4ae9-b392-ed723e4c1568","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164904685","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:b8fd2708-25de-4b8b-bba4-c5c7e43912a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12988","original_object":"UniProtKB:P01116"}
{"id":"97e4490c-fdf5-4911-b195-5884289c2ad4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229230","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:b3940064-aef7-4d7b-8175-1e5fd304ae28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9331","original_object":"UniProtKB:O95977"}
{"id":"ace27e9f-f36a-4236-a7eb-24cc9d97efdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2340","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:a71978b4-b6a9-4bff-8301-1eac6de5a085","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2340","original_object":"UniProtKB:Q9Z258"}
{"id":"d7c8ce7b-8776-4bc7-9d63-152de3f2e630","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3193","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:0b8105c7-6375-4949-b05b-d9dd13195447","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:342","original_object":"UniProtKB:P11229"}
{"id":"944f797b-53f3-47dc-a469-07c8f4771a9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KE7K32EME8","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:20b194af-4767-4c5a-92ca-769b66f1aca7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9204","original_object":"UniProtKB:P00533"}
{"id":"1c449d22-881a-42cb-a060-34ddb830b399","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86268622","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:f1a913c9-2427-468d-8e40-09470a048a2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10163","original_object":"UniProtKB:P48736"}
{"id":"56ee12c0-5f54-4274-9825-f04e600dc5a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R9X77R42FN","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:99aec5af-d576-40fd-95c0-ad86bdf9e707","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:301","original_object":"UniProtKB:P11229"}
{"id":"2ca55992-4336-4b9c-ba98-757bd75cb841","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47781","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:0412111b-736b-4135-babe-3c453ec8f688","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2399","original_object":"UniProtKB:P23975"}
{"id":"f7ecae47-1225-4ac1-99f8-83f72d3aaef0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2191","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:ee0e2a27-8b9d-45e7-ada3-09ae599e69be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2191","original_object":"UniProtKB:P70536"}
{"id":"184753ac-c140-4475-bde2-76872fd6986e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1285","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:e3aa3574-4b69-4965-b993-e6ebcd411417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1285","original_object":"UniProtKB:Q969F8"}
{"id":"626ad08c-4e3d-41e5-976e-2eb814aebfb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50915","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:b03e9bae-9ce4-4a43-8a6a-a2dfb6fbb835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8013","original_object":"UniProtKB:P42336"}
{"id":"2d67dd0e-692e-4894-8ac6-b4f9ecf1529c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2351","predicate":"biolink:affects","object":"NCBIGene:5137","sources":[{"id":"urn:uuid:6040bdf6-7080-44d3-a55e-ae4cb613b88c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2351","original_object":"UniProtKB:Q14123"}
{"id":"c1bd4259-8ac3-47d5-ad6a-c5ab7d5756c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:2c564d5c-a45a-401e-a674-0acb73cdb2cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P09619"}
{"id":"efa0a839-a3bd-4712-ad70-a4c20ac55515","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:15563","sources":[{"id":"urn:uuid:de4fbdfa-65b6-45da-8596-8fbb3f3baeb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P30966"}
{"id":"470f136b-9511-420e-baa8-92cf6f61d31c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1207","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:0f5e0df8-186f-4840-a1d8-b93994408ef7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4089","original_object":"UniProtKB:Q14957"}
{"id":"fea4d044-3698-4bfe-a98d-4932e8a13533","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611898","predicate":"biolink:affects","object":"NCBIGene:2053","sources":[{"id":"urn:uuid:6a1a3496-169b-4cd5-be30-6117265f3449","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10002","original_object":"UniProtKB:P34913"}
{"id":"f5d62343-1e78-421d-a1c1-b4b4e10a00e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3618472","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:7ea838d0-29e6-4fad-ad76-719fa6833f65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:834","original_object":"UniProtKB:P25025"}
{"id":"31cc358f-eb12-4151-978e-b236d1720643","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11143","predicate":"biolink:affects","object":"NCBIGene:259197","sources":[{"id":"urn:uuid:79c3c98d-a98e-4bd7-8f51-1d327fd90a6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11143","original_object":"UniProtKB:O14931"}
{"id":"a219455c-dd83-4b40-9133-d5499d8340fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63453","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:816d5b21-e3d2-4c78-863f-c1967e8a90bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7707","original_object":"UniProtKB:P08069"}
{"id":"159c1433-37c8-43df-b468-451dccfb8891","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679539","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:73564312-ccdb-4839-a7e5-3476099a237f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11852","original_object":"UniProtKB:P35414"}
{"id":"90a33d27-e967-4465-bd99-7670dbef5211","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18344","predicate":"biolink:affects","object":"NCBIGene:2859","sources":[{"id":"urn:uuid:140dd996-9705-4b4c-ae93-ef108fbc3b7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2918","original_object":"UniProtKB:Q9HC97"}
{"id":"c1669e58-5463-4587-abc3-ace8439d10a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:BTS1Y6777M","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:ad6d7317-5c5d-479b-a294-bc0a8f2864b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3290","original_object":"UniProtKB:P29274"}
{"id":"ad3e81bc-aeca-4319-88c7-3bb519dccdac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:5e09b28e-73af-471d-9d73-9e01b6ec5b7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P30994"}
{"id":"aafb92ef-dfd9-4151-8c0a-4ce0fcbbfc32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311214","predicate":"biolink:affects","object":"NCBIGene:1815","sources":[{"id":"urn:uuid:3e2f8097-993a-46a6-8d46-4a70e818cb99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3295","original_object":"UniProtKB:P21917"}
{"id":"34df22d4-0329-49ba-b1b5-a8fd9093266f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34018","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:a23f4e60-ad17-4b4d-add8-271884a08a08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4131","original_object":"UniProtKB:P42262"}
{"id":"83c2475f-5379-469c-b7d4-aa15b735a16f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91452","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:d3ac6876-e2ef-49c6-8461-0a84c128c26d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9382","original_object":"UniProtKB:Q05397"}
{"id":"bcf67b4d-359a-4528-a058-563be5c09c8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:8d3318e9-63d8-4e6a-ad94-7b11221931d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P43116"}
{"id":"001915e9-a02d-4440-b8b2-d4349e91bf13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8533","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:315baeb5-6bd9-491c-8c0e-ca4ef794edc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8533","original_object":"UniProtKB:P61073"}
{"id":"660efd73-b130-40d3-a8b4-b8757fe69086","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34919","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:d6b3c7ac-65f4-4203-8fb7-a3e6c401f7cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4281","original_object":"UniProtKB:Q9P0L9"}
{"id":"8ba9f4c5-0002-4360-873c-8816805e4e70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9927707","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:437dbba0-1b2e-4254-878c-3c6559ec1342","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4248","original_object":"UniProtKB:P42263"}
{"id":"0074e8fa-f399-46b3-81f0-036add634344","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EP8475W580","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:c9a52112-9359-4e33-a3ae-e6a7adb7510c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6729","original_object":"UniProtKB:P17764"}
{"id":"b7e3c6fe-c170-41d8-9010-1339727766ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:675566ec-a65f-41d9-bd59-ed45c77c30c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13586","original_object":"UniProtKB:Q08499"}
{"id":"e2b42710-9155-47e2-92f1-1734102eaefb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M5TZP1RWIE","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:32cf996c-7911-4ff5-8b74-1d7f751a6d60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4227","original_object":"UniProtKB:P31644"}
{"id":"86cb5725-4dd0-496d-a0d9-93b68ed5be7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76849261","predicate":"biolink:affects","object":"NCBIGene:24411","sources":[{"id":"urn:uuid:8f6d31c5-18f7-4d70-8875-04b72c8b3d3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7843","original_object":"UniProtKB:Q00961"}
{"id":"996074fd-257e-449b-b66b-5eec9e19a0fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RC2V4W0EYC","predicate":"biolink:affects","object":"NCBIGene:24182","sources":[{"id":"urn:uuid:4ae51ab6-3c98-45b1-bf5d-98ab4af4a55b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6918","original_object":"UniProtKB:P35351"}
{"id":"d7475c41-3d47-4ef5-9b23-784ab3773e9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7542","predicate":"biolink:affects","object":"NCBIGene:18217","sources":[{"id":"urn:uuid:48549931-3cfd-4c67-b5d8-5b731f964bfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1579","original_object":"UniProtKB:P70310"}
{"id":"0324d92c-8283-44b0-b03a-3bd3c0a55230","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:226","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:2eb5ff8f-a81d-4a14-b666-56d6ce543980","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:226","original_object":"UniProtKB:P41595"}
{"id":"c5f89066-471e-494b-8134-1385754b27e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1QMD83K4YN","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:e74ca210-09ac-4ce3-ad2a-1c2319dcce89","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11448","original_object":"UniProtKB:O43613"}
{"id":"69c0c0be-032c-402e-8ea8-0f45710876e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:108147","predicate":"biolink:affects","object":"NCBIGene:21338","sources":[{"id":"urn:uuid:bc478680-5cc4-4306-81d4-e6de644d40f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2127","original_object":"UniProtKB:P47937"}
{"id":"62affbd6-aefb-41eb-8520-3bd509b4a5c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871820","predicate":"biolink:affects","object":"NCBIGene:5593","sources":[{"id":"urn:uuid:16bafe1e-7382-451b-9807-f7d363001d42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8184","original_object":"UniProtKB:Q13237"}
{"id":"f9ca6e65-2ed6-48f6-971d-86134ba7d6ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9570","predicate":"biolink:affects","object":"NCBIGene:1555","sources":[{"id":"urn:uuid:5a204835-d590-4706-8959-bf373c17b978","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7622","original_object":"UniProtKB:P20813"}
{"id":"f3b47602-81b1-4e42-8bc0-4dbbb1f602cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801163","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:56d87882-887e-4f37-b47c-0bb9876399f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9712","original_object":"UniProtKB:P23458"}
{"id":"b1a47609-5d70-4a2e-883e-e92157720f3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:8c7ad18d-97fe-46cf-8e02-b4218a5c8a50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q92952"}
{"id":"9d50cc7b-ae6c-44bf-99f3-8e4dc37a5377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6115","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:23ae5747-5192-40f7-8118-8c617a8f12a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6115","original_object":"UniProtKB:O43603"}
{"id":"3ff61dd5-bc07-49c8-9654-4114ff0a2195","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:157dd6f0-0e69-4b27-b86f-72d3649938d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:P14867"}
{"id":"28c1bc25-af8e-49d6-b45d-ae1016b323da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121964","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:7c6eb3ee-710b-4261-bbd7-abb6cd75ee94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:858","original_object":"UniProtKB:P30551"}
{"id":"751fb21e-e3b1-4785-a109-31ada568f5d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166597670","predicate":"biolink:affects","object":"NCBIGene:84875","sources":[{"id":"urn:uuid:c77f5796-e7f2-4881-9412-e23e7fbde7b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13121","original_object":"UniProtKB:Q53GL7"}
{"id":"43b79283-e9fe-437f-98ba-231663ba0f22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2153","predicate":"biolink:affects","object":"NCBIGene:217369","sources":[{"id":"urn:uuid:968e39a8-1ab4-4dee-a3d2-a4fdae83d99f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2153","original_object":"UniProtKB:Q8VIH9"}
{"id":"1cc34e42-95d9-4898-bb8e-b7fc3b7335e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:598fcca0-15b5-4cd8-9787-5ba0feb304b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q8WUI4"}
{"id":"c6848a73-179c-446a-939a-2fe002623aa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94777","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:e4d6807e-2b1e-4fb3-8196-689f32b743d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7556","original_object":"UniProtKB:P14842"}
{"id":"7ce3cea3-59a0-46ff-8b66-3f9f17067733","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35255","predicate":"biolink:affects","object":"NCBIGene:83795","sources":[{"id":"urn:uuid:e68e4f74-9c83-4b08-b29c-53c18b064f2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2503","original_object":"UniProtKB:Q96T55"}
{"id":"ce882e0b-0161-470e-b819-52722adf1170","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34524","predicate":"biolink:affects","object":"NCBIGene:3709","sources":[{"id":"urn:uuid:aac7c35d-4cf2-41a4-a2a6-8cfa16e5dc4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4124","original_object":"UniProtKB:Q14571"}
{"id":"ceb04c35-26b0-435e-b70f-d2afd0fd5856","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SRV0JCF9LI","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:44e8c0cd-a3db-442e-a986-2aaaad959c58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5685","original_object":"UniProtKB:Q16288"}
{"id":"075ea832-37c1-4e16-be7c-0176648fb7cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167652","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:8c59c265-605b-4657-bd46-6425ff7d7bc9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8478","original_object":"UniProtKB:P49841"}
{"id":"1d894cb0-c38f-4b5d-ac1e-8ebebf9c2702","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311198","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:e3345657-c80b-424e-b124-6ce5b55bad4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1359","original_object":"UniProtKB:P48039"}
{"id":"ae9223bb-d4e1-45f6-bf68-9e9dc9010f4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:192545","predicate":"biolink:affects","object":"NCBIGene:2913","sources":[{"id":"urn:uuid:0641818c-e2c5-47b8-a657-c47df84adda6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1394","original_object":"UniProtKB:Q14832"}
{"id":"80da491c-30ef-4ca6-aa7f-34198a847611","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10119","predicate":"biolink:affects","object":"NCBIGene:6331","sources":[{"id":"urn:uuid:47c8fae0-1f3c-4d8a-b116-ce7e4d3681d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10119","original_object":"UniProtKB:Q14524"}
{"id":"f699708d-b7f0-4fbf-bfc5-7fa6e49d1e2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311350","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:73bee953-9dba-462d-9904-196c3ec57da3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2125","original_object":"UniProtKB:P29371"}
{"id":"655692e0-c72f-4f09-a64e-11151c44d066","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3242","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:832c0927-896e-4b8f-96ab-6cd536438c51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7591","original_object":"UniProtKB:P35372"}
{"id":"1500b3d0-8026-4de1-8fa6-d1b32e827fae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16610","predicate":"biolink:affects","object":"NCBIGene:16518","sources":[{"id":"urn:uuid:c48dd353-e74e-4cc8-8b1d-8b0225fe11aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2390","original_object":"UniProtKB:P35561"}
{"id":"c0000844-e6ed-41d5-be44-90bb3b8a50b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3542","predicate":"biolink:affects","object":"NCBIGene:25024","sources":[{"id":"urn:uuid:ecb19dc7-a064-4a07-baa5-27a5a4c7ace1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3542","original_object":"UniProtKB:P43219"}
{"id":"3711302e-0208-4768-a9be-75e42fa2f2ac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144551","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:e0571b82-8724-454d-88d6-8afa8dc3fe80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:359","original_object":"UniProtKB:P08172"}
{"id":"b709930b-7853-4644-94de-4530144dba6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:94ffba6a-452a-4b1d-a5d5-9f6b0fa46125","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:Q9UL62"}
{"id":"6d00dbea-7752-4d67-8288-18b9853d662c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:43J9Q56T3W","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:330b7e4b-31f5-455c-b4f4-1cdcff220c4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8969","original_object":"UniProtKB:P42336"}
{"id":"acfbe436-814a-41a6-bd2c-530a35dda239","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68610","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:a7286984-910a-446c-9799-79575d3df5b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6318","original_object":"UniProtKB:P27487"}
{"id":"c1c30102-230c-4d94-ac3f-e09df4613131","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195326","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:39feda6e-fa1a-4df7-b2f7-4be7e1888438","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1323","original_object":"UniProtKB:Q01726"}
{"id":"48f20701-a071-43e2-8cb8-f5986c3dfa94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:845","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:f8e3f5fb-ef25-48a7-99ff-56721013a9ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:845","original_object":"UniProtKB:P61073"}
{"id":"96a89802-913d-4fff-98bc-fab0f3e1aadd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91408","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:5daed4a9-95eb-4312-8349-13e23cc15d1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5716","original_object":"UniProtKB:P23458"}
{"id":"937a28a9-cb49-4555-9605-a379ac12a22f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LJA4M1L5LG","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:1d655e24-9df8-4352-b5b3-a71fe19fb78a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5595","original_object":"UniProtKB:P29274"}
{"id":"3bfdea58-22ec-433f-b031-5d545ee07db4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155128767","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:826d6a09-96f7-445e-97f3-4cf17882276e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12520","original_object":"UniProtKB:P43116"}
{"id":"d56b6aca-8af8-488a-85c6-12f2ed1372bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:581F7DFA9B","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:b5a9c475-5c28-4b69-a7b2-b38fc181b392","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10058","original_object":"UniProtKB:P21554"}
{"id":"a5e865ae-ea13-4bb0-9f7e-061f3677c446","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164946726","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:a4f21d07-42ce-40a6-9e4b-355e605eb566","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12238","original_object":"UniProtKB:Q86TI2"}
{"id":"82baaa60-f966-401e-b049-c7e288ebd510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165412765","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:8fe16e65-7687-4ee6-98dc-9e0b07e7a229","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12524","original_object":"UniProtKB:Q9H1C0"}
{"id":"6750b0e5-c25b-40dc-99a9-aa092f3eeb32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:133081973","predicate":"biolink:affects","object":"NCBIGene:27035","sources":[{"id":"urn:uuid:1aab6a5f-fe2c-4e8a-9f61-64a602f57675","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9933","original_object":"UniProtKB:Q9Y5S8"}
{"id":"73a4b1b5-edc6-4a56-954a-23151ca75046","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:194387","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:b81cd2fd-dfe0-49d4-a4ce-c6f7c2edcfc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1393","original_object":"UniProtKB:P31422"}
{"id":"a87be719-75e9-47db-9301-4f7e36e6589a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PQ7O0OB5GU","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:06302347-49c0-4b82-ba32-88e737b862f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10231","original_object":"UniProtKB:Q06187"}
{"id":"1c8265c7-af0a-4f41-b698-62cf65f4c2a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:039fbd23-cc84-4c45-a7aa-bd6b0c005255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P28222"}
{"id":"e9acb516-2f18-4b61-a491-567151f766bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3665","predicate":"biolink:affects","object":"NCBIGene:229214","sources":[{"id":"urn:uuid:ab3b4dac-502f-4c14-9946-6b9955bd2c3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3665","original_object":"UniProtKB:P83861"}
{"id":"6bf31f75-64aa-4ece-a63a-ca8bb6198a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:663","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:07b5fb65-972a-4ebb-b043-26e39a31fbe9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:663","original_object":"UniProtKB:Q61125"}
{"id":"bc34f593-15ae-42f8-a0cd-e08be2735e51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:858f6f28-a058-4e44-bd3b-0e1d1e80c886","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:P15389"}
{"id":"8d7b2f0f-d50c-4021-9a23-1a66368aca14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71462653","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:f197cfdb-b98c-453a-a7ab-8d084979c41e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7504","original_object":"UniProtKB:Q9UBN7"}
{"id":"2f9d475c-344f-4dd0-a01a-93d5b3051586","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2383","predicate":"biolink:affects","object":"NCBIGene:3758","sources":[{"id":"urn:uuid:17bf4698-7d8a-4e27-9b2b-5060452766eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2383","original_object":"UniProtKB:P48048"}
{"id":"5b8a9ebc-af9e-49b9-aa48-ffacee269930","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:200959","sources":[{"id":"urn:uuid:9c84a3b4-4630-435c-90af-e206e78245d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:A8MPY1"}
{"id":"a0e79f24-e25b-4d7e-a08c-9bb2c297cec7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5130","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:df19d6cb-2917-4c4b-b9b6-377b18c89567","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4194","original_object":"UniProtKB:P23219"}
{"id":"2b00204e-5a43-4101-978e-b09574fb3520","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2440","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:2bfa6850-6c2d-445a-a133-a444e87428fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2440","original_object":"UniProtKB:Q15858"}
{"id":"2007d9ea-967b-42ee-accc-ededd703cf85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7758","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:09fe7919-73df-44c9-9455-d00465781e0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7758","original_object":"UniProtKB:Q17ST2"}
{"id":"36f8cd01-8476-45ec-a643-099e8b582616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86305217","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:75bd2c65-0743-4acd-b2db-ff2b2d1c4912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12050","original_object":"UniProtKB:Q12879"}
{"id":"959cb78e-bfa6-4fde-8cc2-91cfab1f120c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:177233","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:908fe179-94af-48d3-990f-8d14907fe9ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:285","original_object":"UniProtKB:P11229"}
{"id":"04658ec7-e55f-4a25-a701-c84adc3da133","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9557","predicate":"biolink:affects","object":"NCBIGene:2205","sources":[{"id":"urn:uuid:21fa9585-35c2-4ba7-bedd-31cb367cda7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"binding","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9557","original_object":"UniProtKB:P12319"}
{"id":"66f2e813-f856-4d87-9a26-e59e990966f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10252","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:657eff01-a395-42ca-af60-f41e1257e7ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10252","original_object":"UniProtKB:Q96P65"}
{"id":"0cc12931-b44e-488d-b7c5-160ce06b0bee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6627LI8F9K","predicate":"biolink:affects","object":"NCBIGene:116509","sources":[{"id":"urn:uuid:117d7613-d5d4-46f9-a253-62ecd5037d07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11296","original_object":"UniProtKB:P28572"}
{"id":"15902064-c87d-4161-8bad-55a9250c6f78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311190","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:4bad866d-9f66-4c26-b07d-5cbc4ae2f21f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:957","original_object":"UniProtKB:P35462"}
{"id":"4a6a3a46-a4b7-4542-b00d-23430a63da89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6015","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:a5c2446d-7484-4fda-aaf4-bbea1e24a70f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2505","original_object":"UniProtKB:Q6RI86"}
{"id":"c1acd603-8c49-4525-9fc2-fe683013b0ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:771","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:08d10ac5-7a05-4b36-a233-99a68002568f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:771","original_object":"UniProtKB:P51681"}
{"id":"c7f4633d-a3a3-4496-9646-cac79ec9eb06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:cee63070-9103-4a09-8a0e-fb7515461c7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P35408"}
{"id":"f819f983-0d76-4e25-925f-838eb512f605","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1MTK0BPN8V","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:d66d3746-a7c1-4545-a347-0143a02aa1f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11333","original_object":"UniProtKB:P0DTC2"}
{"id":"91156aee-38cd-40fd-b224-19489a06e5ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134718","predicate":"biolink:affects","object":"NCBIGene:4129","sources":[{"id":"urn:uuid:bb9cb12f-e0d0-40fc-b373-d94448839e86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8291","original_object":"UniProtKB:P27338"}
{"id":"d67b2055-bba4-4fe1-b230-0bb87495d0a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6324614","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:ad978bea-01a0-43a5-ab62-354d07bff4ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4109","original_object":"UniProtKB:Q8NER1"}
{"id":"49ed1127-bffb-42a7-8d58-d10ed407934f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W71J4X250V","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:2d1a559b-511a-4016-aac5-6d3d7b88ea1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8382","original_object":"UniProtKB:P42338"}
{"id":"28e6968b-22bb-41bb-8134-ba172fedf8b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:4313","sources":[{"id":"urn:uuid:c895a0f7-e1e7-48bd-9fef-49e387daa671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:P08253"}
{"id":"294a74c4-e779-4c68-89ce-d982d4b7359b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8107","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:7a668a52-4539-4000-9548-89c8783d9a08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2624","original_object":"UniProtKB:Q99250"}
{"id":"3e07e07b-e554-4905-8f2d-52940a561976","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11681998","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:0c4f73e3-d479-422e-8f5a-1535b0114b92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10669","original_object":"UniProtKB:O00763"}
{"id":"9d3051fa-5d50-48c0-8ee8-cf8ae1161673","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155195529","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:a6e18bda-feeb-40b2-be43-fa078f650412","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11747","original_object":"UniProtKB:P16234"}
{"id":"47d07675-872c-43eb-82e4-4e91611dce58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122650693","predicate":"biolink:affects","object":"NCBIGene:27","sources":[{"id":"urn:uuid:351a5100-993e-4fc1-b8aa-532aeedcfce4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12383","original_object":"UniProtKB:P42684"}
{"id":"131fd87b-6bf6-44c8-8701-579fb6b7217a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10200844","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:76ca38a1-5e93-4061-a93b-6f72b71d2403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4116","original_object":"UniProtKB:Q9UHC3"}
{"id":"90ecf26d-809c-4389-b706-7cc7a5681f5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85990","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:f9897d30-cb80-47d7-9b73-4e2e7fba02b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7489","original_object":"UniProtKB:Q13547"}
{"id":"f2c165c8-ca6c-4654-8a8e-42f7c0705f07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:2044001f-85a7-4a03-8afc-13c6474b050f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:Q99572"}
{"id":"367e4507-cb8b-4cdd-b25e-eac8bc9a616d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5068295","predicate":"biolink:affects","object":"NCBIGene:66026","sources":[{"id":"urn:uuid:a8666096-c3e1-4abc-9493-2fa0757e585b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4295","original_object":"UniProtKB:Q9ERZ8"}
{"id":"f13d0019-807e-4d8a-820d-9fbd6d2f5784","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139535055","predicate":"biolink:affects","object":"NCBIGene:8878","sources":[{"id":"urn:uuid:242ba44c-5cac-4631-aab4-399df65132f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12281","original_object":"UniProtKB:Q13501"}
{"id":"3755169e-e4fd-4592-be5d-9233939d93f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1118","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:b4203c67-cdeb-4272-b83a-7697a1af5b7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1118","original_object":"UniProtKB:Q02644"}
{"id":"1557bed4-6c60-4952-a440-5ec4fc80de9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:38de9a80-389f-4bd5-a6b5-7b2e616d0286","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P43119"}
{"id":"6f57a17b-0871-46ab-8712-32ac3136627e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:42f2d0cb-ee23-4d38-8470-0b8113b61755","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P07948"}
{"id":"1b610990-6f70-4863-8c97-bb5addf8b042","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PUX4NYC22L","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:2dd26228-5475-40e6-a753-59c1ace9a76f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1360","original_object":"UniProtKB:P49286"}
{"id":"f3708545-8703-4ac5-aaf4-14468578e0e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91336","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:571ccbf7-058a-48b5-8df4-f01a5c642c9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5718","original_object":"UniProtKB:Q96GD4"}
{"id":"862e544b-07ad-4894-b9e9-a52eb098ad6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:2047","sources":[{"id":"urn:uuid:194260ba-9ee8-4755-8aef-a516d9234ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P54762"}
{"id":"da1db9c6-09f2-47cf-91de-075d48a65b18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91666","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:7d47810a-dd36-432c-aa6b-c34690db6dfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1650","original_object":"UniProtKB:P34975"}
{"id":"48a0245f-5b1c-4711-99ff-ab259704377c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131159","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:82179865-369a-4285-9237-11501eac01a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4235","original_object":"UniProtKB:Q99572"}
{"id":"30c928ce-8ab2-4bca-8b50-03891378d812","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73726","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:73d44786-fadf-4eb4-b4a1-1d35aa914b6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2687","original_object":"UniProtKB:Q03181"}
{"id":"4a891325-ffa0-4a9c-a74c-32cc2333a48f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:24247","sources":[{"id":"urn:uuid:63b88def-3c1c-4048-8e6e-82f5af13462b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:P48442"}
{"id":"c5208309-9393-42ad-b219-0b4c673f7a4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8NMK0UG3HV","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:175a4ec9-119b-49fc-8c39-b0de8d1ec42f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12419","original_object":"UniProtKB:P41146"}
{"id":"d90b7469-f36e-4b31-88cb-8b6e3c9e830f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162369732","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:db8713bc-2f1f-45ce-aa2d-42f780eb74c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11851","original_object":"UniProtKB:P01116"}
{"id":"b6cc2965-be24-4fb6-a5f9-bbd033ae335e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57339564","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:99cec188-d7ef-48c0-92b0-b529666a9e55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1516","original_object":"UniProtKB:Q63447"}
{"id":"665e6c41-f7c7-496d-89c5-ef36a919f071","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:7010","sources":[{"id":"urn:uuid:0430c322-625b-4f13-962e-e488e85106c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:Q02763"}
{"id":"b968cfab-5e42-4713-b133-1d2900784206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10104167","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:7528898b-3656-400a-93f4-85ea16d09d0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6937","original_object":"UniProtKB:P20309"}
{"id":"b65f0ddd-7914-4628-b9ee-9b9771699be7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6754","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:766c1c37-1f94-4df8-9b28-f20ee0d47413","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7221","original_object":"UniProtKB:P35372"}
{"id":"396baec4-2801-4081-bb3f-094f038a73e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44404987","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:397ecddc-ab07-43e9-8375-713330d82a63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1699","original_object":"UniProtKB:O43613"}
{"id":"e74ad02b-768d-4ecc-b981-b356643e6647","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9934746","predicate":"biolink:affects","object":"NCBIGene:5139","sources":[{"id":"urn:uuid:eb670a5e-0986-4ea3-8e13-1bf2c2a85da8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11865","original_object":"UniProtKB:Q14432"}
{"id":"e34b2838-e3d7-4fd2-a77b-0bc6cd2aa995","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10413997","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:a4b42ffa-e8f4-4365-b05a-f7dda1da4874","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2246","original_object":"UniProtKB:P30559"}
{"id":"ef09fb20-8ea2-49a0-81c4-77538ca8a268","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9832756","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:3ebddad3-8637-4971-a400-694f29ca189e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1870","original_object":"UniProtKB:P49683"}
{"id":"176024bd-e5c0-4324-afba-eaaf7b0416de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030535","predicate":"biolink:affects","object":"NCBIGene:5289","sources":[{"id":"urn:uuid:439af372-0d93-454f-860b-cd459efdbd15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10489","original_object":"UniProtKB:Q8NEB9"}
{"id":"f82e6dcc-7f85-4350-b167-8481896ad60e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8107","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:fcdfcb81-aa4b-4717-a595-8a577da1e510","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2624","original_object":"UniProtKB:P04775"}
{"id":"8a82ee61-8e05-4424-8aca-70a82baccd83","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:7bacbe2d-de3c-4197-b85f-10008e1479e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:P23458"}
{"id":"52d21df0-6fd1-4c79-b69f-a57c4da5590c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46865097","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:6c0959f7-3aa3-418d-b88d-5fddd07f3dcf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6424","original_object":"UniProtKB:P31424"}
{"id":"825e6275-5e86-4d0e-b6e3-4f6902c5c609","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177398","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:73300bff-0f66-4990-b8e8-880a389b7d60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5605","original_object":"UniProtKB:P29274"}
{"id":"48e62b11-ce1b-48ee-a19b-5b2262ce83c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4514","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:fae80221-0987-4f4c-91e2-f43c7d6fdf9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:355","original_object":"UniProtKB:P11229"}
{"id":"c805e02b-e8bb-495c-aad7-661a787e979a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2014","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:a8dfeceb-5128-4bd8-ae8f-5aae3e51a9b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2014","original_object":"UniProtKB:P30938"}
{"id":"da70b99b-9086-4c90-ae99-1b6191c2b272","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164286","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:06f74178-2cb8-4b77-91ed-485ff3d138df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2118","original_object":"UniProtKB:P21452"}
{"id":"f10e9d35-4541-4c6f-92c6-1fdeba5e7fc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5041","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:0ba18ee5-8641-4810-b270-6b2b42900f53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:981","original_object":"UniProtKB:P30729"}
{"id":"9fd91c77-36d3-489b-8032-1e071b916257","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13953710","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:280abaf2-9a3c-42df-9916-948d9a411a26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7514","original_object":"UniProtKB:O60885"}
{"id":"db7cbc58-d573-4ed4-9448-db58c85ce284","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:688000M8S8","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:a06cff13-3623-457b-a9ca-1dbfc65c538c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7938","original_object":"UniProtKB:P11802"}
{"id":"0adb9776-397b-4fe8-b751-200885df5e89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699437","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:af90e56b-72ae-420d-9016-921f38ad3618","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7648","original_object":"UniProtKB:P07949"}
{"id":"33feaf46-15ea-49d9-9968-8766aba52cc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11844232","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:16c366c5-f2d1-4d30-8d16-3ac54e1a5f13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11176","original_object":"UniProtKB:P0C6U8"}
{"id":"0cb81189-ac2f-4af1-8c9f-9b2f45e0e623","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2566","sources":[{"id":"urn:uuid:897dbdb5-af4d-4059-9487-66c8a2960cfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P18507"}
{"id":"80d5a253-799f-4519-a276-dac3ed92f97a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90295","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:305e0fa8-8dde-4776-b3b3-5e3eba6d29c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5703","original_object":"UniProtKB:P15056"}
{"id":"7991b00f-8ef0-44fc-8954-bf3dea9290df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817465","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:ffcef8b9-90fe-439c-bcd2-7aeecb23994c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3876","original_object":"UniProtKB:Q62805"}
{"id":"1c64c9f4-cd70-4123-910e-8be25784ef19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163695694","predicate":"biolink:affects","object":"UniProtKB:P0C6X7","sources":[{"id":"urn:uuid:26de6fed-48ed-4cbf-8d6c-97d1bc7959a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12587","original_object":"UniProtKB:P0C6X7"}
{"id":"7fd55ee9-a8d6-4c7f-844a-0e8e4b06f7b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64318","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:7108a9af-fe40-4555-8678-e4d54513643e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:149","original_object":"UniProtKB:P14842"}
{"id":"df7e315a-8fc7-4fe7-a014-1971e5d9e808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12516","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:87562bff-d6e4-4d7a-bb88-a04443466912","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12516","original_object":"UniProtKB:P21730"}
{"id":"2ad18495-83d3-49da-ba9b-0289d015e200","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11670435","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:0fc0683d-b6ca-4c58-bd02-ba5e912aa4e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7357","original_object":"UniProtKB:P28845"}
{"id":"859bdaed-6651-4cf9-bf72-37c9c444411c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167660","predicate":"biolink:affects","object":"UniProtKB:P49356","sources":[{"id":"urn:uuid:04f44fbe-33d6-4c89-93b3-853293f71d3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8028","original_object":"UniProtKB:P49356"}
{"id":"4fe193ff-b7c9-4ccd-8798-d32b0efe3edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O880NM097T","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:24e7f6b4-2981-46b4-ace2-0523a7c608bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9450","original_object":"UniProtKB:P21730"}
{"id":"0420c05a-88aa-4a99-9ab5-7cc08aa25631","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494342","predicate":"biolink:affects","object":"NCBIGene:54814","sources":[{"id":"urn:uuid:c857677f-6de5-449a-bbf7-5a2213ca5083","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13401","original_object":"UniProtKB:Q9NXS2"}
{"id":"f71fcc23-741f-4521-b259-bb314a59ff52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27432","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:fad74be2-d2a4-4c50-ad76-d3f0644bae73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1049","original_object":"UniProtKB:O14842"}
{"id":"88b777b8-7497-4243-9ee4-c234dea90111","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7763","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:609f5394-35fa-461b-a0cf-8e9641a40498","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7763","original_object":"UniProtKB:P31391"}
{"id":"8cc69415-f0d6-420a-ab6f-8426ee78baa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86272865","predicate":"biolink:affects","object":"NCBIGene:3685","sources":[{"id":"urn:uuid:61710469-d919-4de4-8ce1-e9f524b55df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12736","original_object":"UniProtKB:P06756"}
{"id":"3542c967-b7e0-4636-b8b8-84d4bcd88014","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135743630","predicate":"biolink:affects","object":"NCBIGene:56720","sources":[{"id":"urn:uuid:0622e1ce-f26d-41a6-a952-14cc84c038b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9016","original_object":"UniProtKB:P48776"}
{"id":"25376020-00af-45f8-aeaa-0f90c5a178b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138319775","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:2109ff9f-966d-4da6-b68e-35b3b4bfdb6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11568","original_object":"UniProtKB:P15056"}
{"id":"c6c57b97-1858-4a92-a0f4-6a4ef1e2cdaf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H94WRL71FP","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:5e675023-3969-4e07-842b-d63f495bb0f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9746","original_object":"UniProtKB:P21730"}
{"id":"3fcedd4b-0cd4-42b0-b593-74cc1c6a86cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OY0E00K11M","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:07e0ab2a-70a6-428d-adf3-54b410a0c7d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6698","original_object":"UniProtKB:P10275"}
{"id":"dea7b584-c8d7-405d-b1bf-97ff086b3a54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95089","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:ae705d0d-7fed-40c6-9f7c-40e219fb9c67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7887","original_object":"UniProtKB:Q9Y243"}
{"id":"588ee149-4538-4fd6-a93e-1b1d4f546848","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6101","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:454732b6-ec20-4de7-812b-3eea72e0e162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6101","original_object":"UniProtKB:O43603"}
{"id":"8a49679e-75bb-4da6-a956-464e692fcfdc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9453","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:8ec95589-2ac4-4b31-9016-69b8f8b52782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2608","original_object":"UniProtKB:Q12809"}
{"id":"c9650d27-5fab-4cbd-83d9-2a4adf35086c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O3MNS8782H","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:2217e116-d278-4f93-86ac-b08b3d675bca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9698","original_object":"UniProtKB:Q9UM73"}
{"id":"2fd8799a-4395-497a-be10-fbe51b123012","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8764","predicate":"biolink:affects","object":"NCBIGene:3614","sources":[{"id":"urn:uuid:66a69d7f-917b-4282-b19e-a7a51c744049","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6831","original_object":"UniProtKB:P20839"}
{"id":"9a548f06-0eed-4c4e-9e35-d42e9a444709","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71604307","predicate":"biolink:affects","object":"NCBIGene:5598","sources":[{"id":"urn:uuid:16eaba46-e4f2-4ace-97b6-7284854ffb47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9406","original_object":"UniProtKB:Q13164"}
{"id":"58fe26fd-25ec-4b28-888a-fdf96fb0504e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135285","predicate":"biolink:affects","object":"NCBIGene:54878","sources":[{"id":"urn:uuid:ecc92fad-10fe-4c01-ad0a-cf6430370389","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6310","original_object":"UniProtKB:Q6V1X1"}
{"id":"3811abc6-e0be-4b0e-8b4c-5f36cb323f0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:101d3fcb-248b-4f6a-aa43-86f789689c1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:P22894"}
{"id":"6be5f1e2-a3e3-4da6-bfbc-7704a330e950","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11462","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:56009a90-c61a-4021-a7ba-6284b3a9c5bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11462","original_object":"UniProtKB:Q8WXD0"}
{"id":"2be52863-2dd5-47dc-bdc7-7723676058c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3048","predicate":"biolink:affects","object":"NCBIGene:24898","sources":[{"id":"urn:uuid:b477254d-740a-419b-b07d-a01c25e80a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7601","original_object":"UniProtKB:P23977"}
{"id":"c8055ebe-adeb-4f3b-aba3-0e1a4cb27fbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030520","predicate":"biolink:affects","object":"NCBIGene:2534","sources":[{"id":"urn:uuid:45dd31d5-abeb-4150-bad7-98acc86affc2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10428","original_object":"UniProtKB:P06241"}
{"id":"ba3bea87-3f9f-4956-8e05-578014faf529","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176744","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:0cb011da-63b1-4cc1-b314-e7860e2b08c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1925","original_object":"UniProtKB:Q62928"}
{"id":"a699e5de-5421-4420-8ba9-faf72b099c66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1569","predicate":"biolink:affects","object":"NCBIGene:23620","sources":[{"id":"urn:uuid:a04d3d45-3e5c-464c-a771-73df5870e826","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1569","original_object":"UniProtKB:O95665"}
{"id":"68b23805-3b70-4bb0-a468-443139881415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623329","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:8ed3691b-94ef-4cb4-b486-f094ebc919a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8301","original_object":"UniProtKB:P27487"}
{"id":"0255f4ee-ae54-42df-8622-8f945b0c01a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:fbd85e0b-4201-4b72-921c-56cda7d6be87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q969S8"}
{"id":"a3e5ad70-b292-4eab-85c2-e1bd66dfee60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17211","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:dfe046af-9794-4768-95fa-eff9792ff074","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3051","original_object":"UniProtKB:Q62967"}
{"id":"9e80aa94-f017-4983-8160-5e217564e7e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135524168","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:37538a4f-e42e-4ff9-90d9-2579c06051e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8178","original_object":"UniProtKB:O14965"}
{"id":"9a029f47-617e-4730-aa68-97ee465713a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:a1de376c-3567-483a-b124-4b66b725af81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:Q91ZY1"}
{"id":"f8e8839e-7c9a-42b1-a846-0f5076ff0421","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9144","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:84e59b0f-2d68-4ee7-8182-ed75374ccd57","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12449","original_object":"UniProtKB:Q9NYV8"}
{"id":"ad72cd3e-cfd8-4781-a508-a0a2f8dc8993","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73289","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:5122e1b2-52a2-495c-8dd4-b7d999f53d7e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:543","original_object":"UniProtKB:P13945"}
{"id":"b6e923ef-bc16-4d72-a3e0-41da6a466714","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156417714","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:18482c31-9530-4c57-b982-a6bb3dd22891","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13879","original_object":"UniProtKB:O43614"}
{"id":"0e7a5c5a-a0ec-4fa8-9d73-7d3afbd5d46a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71529770","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:dc9cbe23-25b9-4935-91f0-6cd0206298d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8166","original_object":"UniProtKB:Q13627"}
{"id":"e4247b1b-91a4-47c0-87f0-02c09495282d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139412850","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:8b122518-b143-43a1-9a75-ec187d4f7aed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13208","original_object":"UniProtKB:P23458"}
{"id":"f18b9839-8eb7-44b6-84ad-0a9c7f269c7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1039LG569Y","predicate":"biolink:affects","object":"NCBIGene:85268","sources":[{"id":"urn:uuid:6813d5bd-dffa-40ac-9534-ccfa60ab4000","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1258","original_object":"UniProtKB:Q9QYN8"}
{"id":"a3b3292d-70ff-4255-822f-edac5a083ec1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:879OVM0Y1S","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:307f26f9-0e00-4ef9-a87a-4a8d1e9602a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10043","original_object":"UniProtKB:O14842"}
{"id":"65784378-25e1-4596-a0c8-d9d1ca05f6de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:69586250","predicate":"biolink:affects","object":"NCBIGene:2171","sources":[{"id":"urn:uuid:a6d46cc2-6073-4856-9e74-32c9a96c85e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8797","original_object":"UniProtKB:Q01469"}
{"id":"1a807b56-bdee-4308-bc27-054db85404e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TSG6XHX09R","predicate":"biolink:affects","object":"NCBIGene:6328","sources":[{"id":"urn:uuid:4352a635-2889-4ef9-b655-7b69a57fb54a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2619","original_object":"UniProtKB:Q9NY46"}
{"id":"2757a2cc-5a38-480d-964c-089e3e38ac86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:22146595","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:4ebc3b2b-9c9c-4b88-aa85-53476d31b108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:618","original_object":"UniProtKB:P52500"}
{"id":"0f83871a-537c-4f5a-b2ee-60e297b016b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10247549","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:f0d28802-d899-4e20-8c8c-fc411bc4c75f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:392","original_object":"UniProtKB:P29274"}
{"id":"6e90e1c4-1bd1-43da-bdf7-fc209e1d336e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64001","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:da8eccd8-8564-48dd-ac2d-b5edf53d45f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"biased_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8443","original_object":"UniProtKB:P21728"}
{"id":"51f0ca50-b3a7-4d4e-be08-de8b9fcf943f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132574707","predicate":"biolink:affects","object":"NCBIGene:5030","sources":[{"id":"urn:uuid:c3887c71-1d2c-4c64-9984-ea41bc20b0c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11451","original_object":"UniProtKB:P51582"}
{"id":"12de06af-7128-4470-9268-0ab8757ebc02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169494244","predicate":"biolink:affects","object":"NCBIGene:25976","sources":[{"id":"urn:uuid:77d97689-827e-4d48-a602-58fe1b2da55a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13117","original_object":"UniProtKB:Q7Z3E1"}
{"id":"60e019c7-2f4d-4df7-a812-413c911dba7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:71e85044-7920-4242-91e0-145223f618d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P36888"}
{"id":"958463a3-df7c-4ebb-b0c9-fada895ee977","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44478401","predicate":"biolink:affects","object":"NCBIGene:1969","sources":[{"id":"urn:uuid:86e37247-1416-4f6d-9732-2cfffb93ef17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8141","original_object":"UniProtKB:P29317"}
{"id":"f6751b4a-a612-4d5c-9117-d49308d097bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YO029HR229","predicate":"biolink:affects","object":"NCBIGene:84634","sources":[{"id":"urn:uuid:d62e088f-276c-475a-8eb9-8ec5d1741e5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10222","original_object":"UniProtKB:Q969F8"}
{"id":"7c280025-52c8-4fb4-8bd2-43a30e4c834a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16078986","predicate":"biolink:affects","object":"NCBIGene:117264","sources":[{"id":"urn:uuid:2fae7f68-b086-41ed-8568-7735fe9bcfe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1753","original_object":"UniProtKB:Q63371"}
{"id":"1f4180e7-9103-4305-aff4-d6ee6f9aa9f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169422749","predicate":"biolink:affects","object":"NCBIGene:1195","sources":[{"id":"urn:uuid:ab195701-9cd2-4a1b-871c-05d3b1c9ad0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12975","original_object":"UniProtKB:P49759"}
{"id":"ca6877df-dc22-4f54-a7c8-9eb0d7c0a45e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:c4cbfdce-e099-4c36-8759-e61233ceb4f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q9UBN7"}
{"id":"bf436df5-3669-48d1-8357-a6893d04edba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53325874","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:79e12945-9a84-423d-ab9c-b4ac97c4d766","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4121","original_object":"UniProtKB:Q99572"}
{"id":"3974c47c-6792-47d3-bab7-cf7c5eaf7ba1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4099342","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:275730b9-b8a1-406a-8e68-6c6fdbc9aadd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9867","original_object":"UniProtKB:P51449"}
{"id":"0c452b4c-0bb3-49bf-8a2b-615aeff83aff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6289","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:44fb7620-b041-4656-83b9-39d0452b4572","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6289","original_object":"UniProtKB:Q8BLA8"}
{"id":"31c7333f-252b-4f42-a306-9bb18f606e9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51137","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:c4139b00-bf98-40dd-bb45-4850a1643520","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:135","original_object":"UniProtKB:P35368"}
{"id":"ca37f8d4-a2a1-486d-b8b3-63885a82376b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:99GS5XTB51","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:0baa4d16-5ec5-471d-b2ed-bb7c1c3466d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9696","original_object":"UniProtKB:P29597"}
{"id":"0ec3acf9-0ee5-42d0-88cc-1d607bd7ae49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91385","predicate":"biolink:affects","object":"NCBIGene:1111","sources":[{"id":"urn:uuid:8545d76d-6a3f-4e81-b180-0c3eaa79df82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8043","original_object":"UniProtKB:O14757"}
{"id":"0178eeae-3b42-43e0-bd32-40fa88af2296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925685","predicate":"biolink:affects","object":"NCBIGene:9263","sources":[{"id":"urn:uuid:d4464913-a8d0-469e-949b-6c3ab16999d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10597","original_object":"UniProtKB:Q9UEE5"}
{"id":"d3cbde10-3321-423f-a011-937741d059b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9AU7XUV31A","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:35879449-1652-4266-a63d-856e4e855721","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7997","original_object":"UniProtKB:P37268"}
{"id":"f32126b3-698d-4bc4-b863-34ddd967e559","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31174","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:9db12383-215b-4932-94d7-47e20716161d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5429","original_object":"UniProtKB:P10276"}
{"id":"43312b1f-8b7b-49d6-a016-6d5806d82f1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16236","predicate":"biolink:affects","object":"NCBIGene:16519","sources":[{"id":"urn:uuid:2e860d2a-1033-458c-9f59-f2f5a68fc2e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2299","original_object":"UniProtKB:P63250"}
{"id":"7eee9b6f-3d96-49ab-b67a-ff49d85bea2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90466261","predicate":"biolink:affects","object":"NCBIGene:5747","sources":[{"id":"urn:uuid:9d2ccaf3-74f3-4261-ac9f-e35052854032","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13032","original_object":"UniProtKB:Q05397"}
{"id":"e41e02c3-df15-4122-9f5e-50da014e580f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50673","predicate":"biolink:affects","object":"NCBIGene:7173","sources":[{"id":"urn:uuid:c7602dba-d2c5-4ee2-b4b0-2c4dafa410ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6649","original_object":"UniProtKB:P07202"}
{"id":"d7a2594c-50fa-4f06-985e-e0e3ce069bb1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92508","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:151b620c-d6e8-4974-b868-56520f666648","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3988","original_object":"UniProtKB:P36544"}
{"id":"fadca74e-242a-4f09-80ef-1044ff53fbc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:a7209b17-3848-415e-9ffd-be2ea0c7450e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P30994"}
{"id":"6b4b549a-0f92-436a-bde0-584c78c4d94d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25108278","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:60d06160-45bb-423e-b112-90e666680cd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9460","original_object":"UniProtKB:P55085"}
{"id":"962f15f2-f2ec-43b3-8329-f3f2e54bc206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:4b3b4650-02b0-4bc9-9f6a-2ac121ffad44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:O88626"}
{"id":"643fa310-7ced-46df-878f-d8f829676309","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93822","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:63536c1a-8295-42ef-8afd-000cb977dacb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1367","original_object":"UniProtKB:P31424"}
{"id":"c616a323-afd4-47b1-85d2-32177b3190d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10247549","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:3fb94eff-d014-4937-9b0d-def633f4516b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:392","original_object":"UniProtKB:P25099"}
{"id":"0c2f9c33-871d-4e4e-9f04-d2f43b798d85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:61325632-3532-4592-9742-a40620a02ec6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P28223"}
{"id":"15bcca18-6870-4fa8-a2ca-001be72a183c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2188","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:66df0fb6-0f04-4f5b-87f2-a6e4087ae617","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2188","original_object":"UniProtKB:P70536"}
{"id":"483d28fa-6782-422d-944c-7a3568cc87c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91668541","predicate":"biolink:affects","object":"NCBIGene:65980","sources":[{"id":"urn:uuid:870e7d18-c91a-40ad-a201-72e602c6e4cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8397","original_object":"UniProtKB:Q9H8M2"}
{"id":"6e56632a-2566-4385-942d-5d0245ce1389","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47780","predicate":"biolink:affects","object":"NCBIGene:16521","sources":[{"id":"urn:uuid:87344c8c-0b46-4d44-9869-00a3619ce428","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2398","original_object":"UniProtKB:P48545"}
{"id":"6b602dd3-88cd-4a5a-95a7-97927502f8c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6139","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:aa1771a7-1465-493e-8612-3c6e08c4a232","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6139","original_object":"UniProtKB:O88626"}
{"id":"389a3241-68a5-44cb-8560-a60c732507c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T875VN0D6E","predicate":"biolink:affects","object":"NCBIGene:4882","sources":[{"id":"urn:uuid:81dfd6e4-c2d9-4775-8902-8f339bb090cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9162","original_object":"UniProtKB:P20594"}
{"id":"0d8f202f-2073-4d36-acd7-603a7c264599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23648296","predicate":"biolink:affects","object":"NCBIGene:1520","sources":[{"id":"urn:uuid:438b4e4e-1416-4cf4-86e4-975144943b94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9298","original_object":"UniProtKB:P25774"}
{"id":"e9ecf740-c903-4830-b6e6-18670fe8b992","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8375F9S90C","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:52411b7d-b24a-45ad-b0ea-abd9f734dc1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12345","original_object":"UniProtKB:P09874"}
{"id":"099cac50-0f3d-414e-b3e2-2ac16933cda7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:3777","sources":[{"id":"urn:uuid:78278cd3-8b1e-4683-9bba-03a123333387","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2364","original_object":"UniProtKB:O14649"}
{"id":"c7b5af43-d6b9-439d-a670-5981e80172a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4215","predicate":"biolink:affects","object":"NCBIGene:4284","sources":[{"id":"urn:uuid:8423709b-9f17-43c4-a57a-5e50ac61328e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4215","original_object":"UniProtKB:P30301"}
{"id":"9f8bce2f-8aaa-4817-951d-03d6507b6fad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947036","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:b4fd59b9-44e0-40f8-9ff4-76117f911395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2988","original_object":"UniProtKB:P51639"}
{"id":"51d07dfc-ecdb-4d72-b1ed-e0787ea56429","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:66d9d452-5e1c-440b-aa94-8b1cff6e89d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:P36888"}
{"id":"b3958c59-c162-4397-b04f-a35b190f2cf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46926513","predicate":"biolink:affects","object":"NCBIGene:1859","sources":[{"id":"urn:uuid:dd210f62-1046-4c06-94cb-0d790fdfcfc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8161","original_object":"UniProtKB:Q13627"}
{"id":"9ab5c604-2615-4c4c-bb85-fbbd6313bbcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229221","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:7f90ebdd-41c0-4928-8961-9f71cdcd6ee3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9428","original_object":"UniProtKB:P35916"}
{"id":"24c9036e-fc5e-4087-a541-81e41c66b41d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10124389","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:8e93a427-6d13-40c3-ac7f-d15da5fc0325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2175","original_object":"UniProtKB:P37288"}
{"id":"0e9722de-088c-4e13-b6dd-9f64fefa6d97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W34UO2M4T6","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:f1167dc3-0e97-4e3d-ae30-b7b7b28925ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5661","original_object":"UniProtKB:O95835"}
{"id":"e252614c-27db-42b2-a173-36c745b1b4ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL69234","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:a0a647c0-e1fd-43c7-a3f7-0224784feb47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1725","original_object":"UniProtKB:Q9BPV8"}
{"id":"3d1f17e1-239c-4de2-9dd7-6e9dad119e88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137064","predicate":"biolink:affects","object":"NCBIGene:658","sources":[{"id":"urn:uuid:cc9d9974-7a6f-4e71-a1cb-e53d776ab8eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7797","original_object":"UniProtKB:O00238"}
{"id":"2388aa60-5ab9-440e-901d-4db3e9393cf2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11675054","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:b77b6257-f81f-41ed-a642-cd0f848fec90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8160","original_object":"UniProtKB:P06493"}
{"id":"82ab54f3-2a11-4adb-8ee1-764c4e65f4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13331","predicate":"biolink:affects","object":"NCBIGene:6622","sources":[{"id":"urn:uuid:f3bfc43a-176c-4984-a4eb-00785425dc23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13331","original_object":"UniProtKB:P37840"}
{"id":"45a19add-0cf1-4a9c-8305-e23f284fac16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16098914","predicate":"biolink:affects","object":"NCBIGene:2160","sources":[{"id":"urn:uuid:4182b2e6-0318-4721-b17f-8e256e4c52b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6549","original_object":"UniProtKB:P03951"}
{"id":"61ff4057-1cbb-4626-bf74-40c53475924c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5305","predicate":"biolink:affects","object":"NCBIGene:5338","sources":[{"id":"urn:uuid:20408ff1-602e-42f8-ab5a-b9145155a9df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5305","original_object":"UniProtKB:O14939"}
{"id":"ffdb922f-f1dd-4c91-8ffc-0eab3c8f3c31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9864959","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:9d04e20e-3b10-4180-907c-ce6e59846ec8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7676","original_object":"UniProtKB:Q12809"}
{"id":"b1ab2f1a-833a-4b38-84ce-7b77ad7f3216","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64195","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:0e44af7f-f933-47c4-838b-a6e00cf0b1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:97","original_object":"UniProtKB:P35348"}
{"id":"2a1a3a28-ca38-4182-955e-60ec6403d601","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:c6cc21ed-23c6-427c-a3a7-2590efb31042","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P35916"}
{"id":"b6fb8d59-4746-428e-a941-b4c4c9a0b023","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T5W3M0VO9B","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:f85bd407-a7dd-461e-aab3-9d8e80098e03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9554","original_object":"UniProtKB:Q13546"}
{"id":"09b7af1b-683e-43ed-b652-ca77ed1c5058","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60182393","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:e9aae0f0-e02a-4aba-83d1-97721b74ed8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8155","original_object":"UniProtKB:P37023"}
{"id":"41f84413-aa66-468f-befc-8b9e0ba418a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57664406","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:2e25d40f-ab27-4afc-bc40-2ebb49bd38c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6938","original_object":"UniProtKB:P08172"}
{"id":"7e8802de-dd12-422e-903e-4491163a11a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53340664","predicate":"biolink:affects","object":"NCBIGene:1445","sources":[{"id":"urn:uuid:00a64d27-dabe-410e-8b54-b6e1bf50ff8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8074","original_object":"UniProtKB:P41240"}
{"id":"5ab6139a-e37e-4330-a87d-960056e54f04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W66XP666AM","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:ddf9e09a-d351-4f71-8f46-e2e027daa5a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9923","original_object":"UniProtKB:Q00535"}
{"id":"91f911fb-aa7c-4ddf-b890-32db770c5c13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135939","predicate":"biolink:affects","object":"NCBIGene:497770","sources":[{"id":"urn:uuid:aa3291ac-1e04-4579-be2b-23a46bc169d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7472","original_object":"UniProtKB:P08104"}
{"id":"a74545d0-3e4c-4b44-8074-8deb0833562b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:5585","sources":[{"id":"urn:uuid:ccd3a2d1-9e68-4851-b395-9870751121f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q16512"}
{"id":"21c8577c-7199-489c-b854-085352da5b07","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34018","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:4b94a4d2-780c-43d4-a4de-d32ee0fa9407","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4077","original_object":"UniProtKB:P48058"}
{"id":"c3b56b4c-ee64-4adb-badb-dd995eeb8e98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146675152","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:017fe376-b9af-4c18-8e91-34f3d9c32f1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11403","original_object":"UniProtKB:O43613"}
{"id":"08e9a2d6-d5c4-48b1-a90e-bde1a5e013a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:931L4X5WMM","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:24337493-51ee-4c52-952b-7b71166a5336","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1226","original_object":"UniProtKB:Q9H3N8"}
{"id":"d80b3eca-6b4a-48ec-b6d0-a74bbbf0292b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6920","predicate":"biolink:affects","object":"NCBIGene:347732","sources":[{"id":"urn:uuid:a4a11dfe-352f-4fc9-8ac5-cf715afb5fdc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2522","original_object":"UniProtKB:Q86XQ3"}
{"id":"682182e6-e695-402b-8c09-1ee6a1b09e30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44580458","predicate":"biolink:affects","object":"NCBIGene:4321","sources":[{"id":"urn:uuid:f11c841c-293e-40d0-8e95-e5190ff9e720","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7812","original_object":"UniProtKB:P39900"}
{"id":"5bc396ac-1cf1-4dfc-8305-040c21e458bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6574","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:e589a00e-439e-4a54-a286-48e11085fc3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12445","original_object":"UniProtKB:Q9NYV8"}
{"id":"4fc48373-05b0-483d-8b41-80e9da822847","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25125014","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:f6d45697-34c1-4991-8679-11e4fc7c8d07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8176","original_object":"UniProtKB:P06493"}
{"id":"bb0eedc0-967a-4e6a-b2b9-e198b855cc4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47856","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:2cfd7253-3790-4b39-b107-6148a4c47472","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6300","original_object":"UniProtKB:P59537"}
{"id":"b1123ae0-bb17-4871-b2ee-21e354a69380","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10310632","predicate":"biolink:affects","object":"NCBIGene:29665","sources":[{"id":"urn:uuid:ee58bd0e-9018-418c-a5e2-14cd591c9968","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9021","original_object":"UniProtKB:Q64663"}
{"id":"2593303a-94c2-4e94-872a-4f9d57962766","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93487","predicate":"biolink:affects","object":"UniProtKB:P31651","sources":[{"id":"urn:uuid:d1102eee-4b7c-482f-bd25-1a61f6164baa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4610","original_object":"UniProtKB:P31651"}
{"id":"19acbc4f-c58b-4ad5-bf66-5ff8d5a66e49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:ad841acb-6042-47c7-8fa9-466640fc73d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P43114"}
{"id":"4d2ab190-2417-44f1-a595-10c32b7f68f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57406537","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:88702752-ce14-4b73-ad46-6459330c9359","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6939","original_object":"UniProtKB:P56817"}
{"id":"923151d0-697f-44f7-8351-ee2f95cdaba8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2027","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:991526cc-6660-48f2-be2c-82d253c0ab0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2027","original_object":"UniProtKB:P35346"}
{"id":"d1295e63-b2aa-4e51-a64a-5c6511ed8c39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86305217","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:15ef6c4f-5ef1-4e47-b53d-3544ece7aecc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12050","original_object":"UniProtKB:Q13224"}
{"id":"913a0d54-7260-4346-9be8-3c980e722fe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92413","predicate":"biolink:affects","object":"NCBIGene:13649","sources":[{"id":"urn:uuid:19a20a8d-be08-458b-be56-4b3987bef399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13719","original_object":"UniProtKB:Q01279"}
{"id":"cf765177-ec31-4b97-9bdf-d0567172efcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53773","predicate":"biolink:affects","object":"NCBIGene:476","sources":[{"id":"urn:uuid:a2018b56-8b2a-41a0-aaf3-4349785c9d4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6794","original_object":"UniProtKB:P05023"}
{"id":"0297fc23-9ff6-47b7-88f6-1d1dfaa06a28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1321","predicate":"biolink:affects","object":"NCBIGene:4159","sources":[{"id":"urn:uuid:c30fe9d0-e096-4c8a-b13b-c7990ebd905f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1321","original_object":"UniProtKB:P41968"}
{"id":"b8551901-fb86-4edd-8967-e042962c106e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817516","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:cd6f3af3-cd86-4f93-83ac-d594b947293f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11425","original_object":"UniProtKB:O60674"}
{"id":"919cbae8-d8a7-415b-baeb-a6e4e792b4dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:655","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:dfa98c61-06d3-421e-843d-302a083d417b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:655","original_object":"UniProtKB:P46663"}
{"id":"227c9da0-e3a7-4fcb-b467-1a0b954ba2a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:663","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:6e822b24-a1c2-45ad-8a5d-91377efe9b97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:663","original_object":"UniProtKB:P46663"}
{"id":"b7f594b0-1d09-471d-a30c-90ac3fecbac5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GGK40O1O85","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:676443ec-b836-4dbb-bf3c-f170d9609182","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9812","original_object":"UniProtKB:P08235"}
{"id":"2f8fc6b5-6b67-4359-9f2d-c4d9a2bcba46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139593562","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:f4d01e33-8140-4040-b2a8-a2cb263f13fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10531","original_object":"UniProtKB:Q00534"}
{"id":"50111597-820d-453b-8dc8-59a2f93f5c8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699463","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:6f649085-0678-41b1-b2a8-db9658b78501","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11220","original_object":"UniProtKB:Q13547"}
{"id":"29f205ed-dc25-4b75-8419-7362ab3434d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:f493929d-e928-4143-b029-2ebb69e0a55a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P28222"}
{"id":"269e0661-2b76-43f2-9c12-52e44cf037ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9137","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:d27928fc-5329-46fc-af2c-324b6e192ba1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2586","original_object":"UniProtKB:Q01959"}
{"id":"3a6844c9-1661-4988-9498-7f0d4f4d6a37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93363","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:d42fa000-dc23-42fc-80cc-cd1e34cd3aab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5509","original_object":"UniProtKB:P35348"}
{"id":"009ad31a-623a-4485-9452-5f8fb551af5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5461879","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:7a073fa7-bcc6-4598-940f-4365107cfc37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5603","original_object":"UniProtKB:P30543"}
{"id":"909ea90b-c3fa-4d45-8f98-dc577eb0ffad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439089","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:6c64ad11-78af-4d9a-b7fb-36711148deb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:443","original_object":"UniProtKB:P0DMS8"}
{"id":"a8e4e119-33be-4df6-982e-82f5478b0d80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73380","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:d3986da5-6420-43a6-afa4-b7e118541a3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:247","original_object":"UniProtKB:Q13639"}
{"id":"48b11194-3ca1-4160-a57c-cc544ad6b522","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:5fa9e1e8-0b63-4ba0-87bf-c8ff112ddd1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P32305"}
{"id":"834f94f1-9a94-48fa-b2d4-a8cc7bce9827","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:24782","sources":[{"id":"urn:uuid:9ed32924-9d48-40e3-a975-51037a05602c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2421","original_object":"UniProtKB:P26431"}
{"id":"0dfd5064-64d3-4cec-9b6e-089fc9de9010","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393287","predicate":"biolink:affects","object":"NCBIGene:2241","sources":[{"id":"urn:uuid:65db0f84-9454-458e-9a28-fa39b24eed71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10367","original_object":"UniProtKB:P16591"}
{"id":"dd280698-6026-4308-8b1a-18ccdf2ba818","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:40D08182TT","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:b66bf08b-1fd1-4b6b-9dc8-fdbc3473289e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9095","original_object":"UniProtKB:O60674"}
{"id":"266565e7-939c-4b97-bf66-f96b1373d686","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:76856","sources":[{"id":"urn:uuid:5331f3d5-21b5-4609-8002-e22b67d529ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q80W99"}
{"id":"762c9395-6afb-4725-b344-904950a3c1dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3TY57MQ4OA","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:989edcf6-5288-4024-83a4-729b535325d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2202","original_object":"UniProtKB:P37288"}
{"id":"cc04857d-8559-4507-abca-d1283bfd2c92","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8163770L8P","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:d313c1ba-e19a-4918-bf8b-0c0f735f2e33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:29","original_object":"UniProtKB:P28222"}
{"id":"deacd306-5b73-47f8-b33c-45221cce9ac0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10125","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:525fabd8-f691-4f76-b608-566a7815da9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4348","original_object":"UniProtKB:P34903"}
{"id":"4a54c287-4318-45e1-ac05-f3d6fd1bdd50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60155209","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:7fbab7e8-1b00-4e4d-8fd2-0a18c02c0070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13409","original_object":"UniProtKB:Q05655"}
{"id":"dc6efef1-67db-491e-8ce3-b308ae1253f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61049","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:ebccf61f-2ceb-4022-9d7d-5c31808f043f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6784","original_object":"UniProtKB:Q7Z2W7"}
{"id":"fc0b4ab4-e5e8-48ca-ba5f-53410a28a8dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28088","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:95bd6da9-7717-4374-a9a7-54ba94af136f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2826","original_object":"UniProtKB:P59534"}
{"id":"ec8157e5-0578-4678-b115-04affe49548a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ZUA56XMQQ","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:ecf11884-f4cf-44d6-8ca6-c3e3608ab8f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8065","original_object":"UniProtKB:P00519"}
{"id":"5b2af55d-557d-4234-9695-e7d4fdfb5642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:609e1724-86b4-4fc1-9c6b-f845995c4bfb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q13507"}
{"id":"1f788640-cc85-4407-800f-d4b6df1c854e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9796408","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:4fcd5c83-c382-4689-924d-3e12160a4711","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:170","original_object":"UniProtKB:P28223"}
{"id":"b9fba39d-ea22-4554-9c39-e030a31e92c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58688563","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:a21b484e-520c-40de-824e-3ddedd57bb8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8119","original_object":"UniProtKB:P53667"}
{"id":"87782118-8aa6-48d3-b958-32addc704304","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:175064","predicate":"biolink:affects","object":"NCBIGene:27133","sources":[{"id":"urn:uuid:27002294-6a41-4c42-818c-2440ceb10722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2606","original_object":"UniProtKB:Q8NCM2"}
{"id":"c813d75f-428c-4d4e-b46f-926c6fd067fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13179","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:07319e2c-7c43-48ce-a36e-8bcf7f1908f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13179","original_object":"UniProtKB:P18089"}
{"id":"5f4cfc86-dca3-4bb3-a57f-b758482857a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57928403","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:56d067ae-14f1-4460-9c55-75e1252a6b83","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8315","original_object":"UniProtKB:O60674"}
{"id":"f514465e-2f4e-4dff-979f-89ee343221d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34727","predicate":"biolink:affects","object":"NCBIGene:2900","sources":[{"id":"urn:uuid:6a8e2aa1-3e3b-4eaa-8bd2-037cf25ed717","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4181","original_object":"UniProtKB:Q16099"}
{"id":"5392d4da-6908-4013-8730-dc084b2ad83d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139035063","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:ba493e6c-4ceb-4bec-bd9b-4302afbc6819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10494","original_object":"UniProtKB:P23219"}
{"id":"18feb772-9a6b-4337-a3c1-603abbaf67a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:62d7fcbe-c2aa-4122-9b23-559b6b342ceb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:Q13258"}
{"id":"a2c65a88-100b-491a-b9de-067591bacaef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TRF8S0U6ON","predicate":"biolink:affects","object":"NCBIGene:7037","sources":[{"id":"urn:uuid:8d5b9bce-7668-4ea1-bb28-f1680c825095","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11772","original_object":"UniProtKB:P02786"}
{"id":"bbb73311-ee24-48e8-8904-26c6157027ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:65c4c478-ee33-4f11-a9e6-188050e2ca14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:P15390"}
{"id":"83b646f6-d802-4662-bcaa-38ca7df96eea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51368","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:712e9e75-56a5-4626-8163-e8f748addf41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9868","original_object":"UniProtKB:P18089"}
{"id":"955025d4-8734-4480-8735-59eec87f0fd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755005","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:2302d2cf-3073-49c7-a47f-5e0b516becbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1751","original_object":"UniProtKB:Q15077"}
{"id":"ccf74c1a-f893-45e6-913f-48c7f4bef9fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O1Q96UZ63W","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:4a66bb67-ffea-43ee-8619-bce198a92530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3281","original_object":"UniProtKB:P30542"}
{"id":"7c7bee60-e881-47d6-920f-fb5cb808fee1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:89855776","predicate":"biolink:affects","object":"NCBIGene:10988","sources":[{"id":"urn:uuid:84dab65a-9bda-4360-8df5-23e4ed775a34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12714","original_object":"UniProtKB:P50579"}
{"id":"2b89cea3-4b0e-46ff-a471-915fb75d4ac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135567181","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:5766345c-f693-4b43-bc31-4caccda628bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9453","original_object":"UniProtKB:O43318"}
{"id":"ec445400-6eca-4358-8ec8-f40c14d1015b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4UQ3S81B25","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:0833dd74-f6f3-4ede-80b2-91ff4f32ad1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:225","original_object":"UniProtKB:P41595"}
{"id":"5f288bef-bd7a-4b06-8b3f-6541279a0232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45378170","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:73e36a83-6c9f-43c1-9da2-28ee6a15b718","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12616","original_object":"UniProtKB:P48736"}
{"id":"5024f149-870b-42ff-b1de-808ccdbd14eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311427","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:5c449e29-8c36-48a0-8ab0-4374bc904372","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3331","original_object":"UniProtKB:P34980"}
{"id":"88ed5eb9-127d-404f-8cfd-014d0bfae590","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QC4F7FKK7I","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:a278d279-2859-40d6-a884-924a0aa99de3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8529","original_object":"UniProtKB:P37288"}
{"id":"bc1a0c07-193f-4ebe-949c-b4e38c95359b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139443340","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:02bf8793-570c-4a17-98eb-2dcbbe74b729","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10577","original_object":"UniProtKB:P13569"}
{"id":"678c4f0a-0198-4aa1-91a9-90f2265770c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5776","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:01961f8f-bb8d-4d7e-bb53-528e5ce594d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5776","original_object":"UniProtKB:Q16581"}
{"id":"dd5c9298-ac60-455a-91b9-be381ffc016d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K7G81N94DT","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:523240fe-499e-4fef-be50-8919fd320303","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2110","original_object":"UniProtKB:P29371"}
{"id":"89c6ce7a-ffdf-436e-81e6-0b36b8e7ea90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229222","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:bb5c4c8f-e4cc-43b3-8ad4-b76093fa581d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7709","original_object":"UniProtKB:P31751"}
{"id":"028b31bd-8270-4859-b01d-155bd5b3ea59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1322","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:857a2de5-8a14-4e09-a156-754bd312ef81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1322","original_object":"UniProtKB:Q01726"}
{"id":"89384a87-d57c-4c5a-a653-7abff444aad5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90620","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:491c753b-0bb0-43d9-a6e7-9e73e2700bd8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5705","original_object":"UniProtKB:P35968"}
{"id":"5aa3d925-dc7f-4c7e-8e93-d330af3faa9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JS9NP12Y1Y","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:e8b8ed0d-88aa-4d8f-92ac-ed7f0ad656af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4030","original_object":"UniProtKB:Q9HBW0"}
{"id":"2ced07b6-3b52-461d-97a4-a8bccb520d49","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:84500","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:6d44d715-259e-496e-a5bc-6b42a71a37eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5459","original_object":"UniProtKB:P32297"}
{"id":"9d91c4a2-24bd-4fb7-8415-d8a8912066ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23682233","predicate":"biolink:affects","object":"NCBIGene:2846","sources":[{"id":"urn:uuid:832d86ef-ca42-4cd9-97cb-85fcc99f3b8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6991","original_object":"UniProtKB:Q99677"}
{"id":"4c9497cb-ceb6-4190-8fb6-402a1f7e7bae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993643","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:f5f046f5-f55e-4c07-839f-5dc08ae84480","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12486","original_object":"UniProtKB:P08173"}
{"id":"bf37a402-8c82-48bc-ac5d-08da8ab8c396","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:21707a2e-c231-405f-a49f-fc679e5ca6cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4259","original_object":"UniProtKB:P48169"}
{"id":"5e1cc199-65b5-4f47-b402-fb610c706a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92426","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:4af3f53c-6449-4829-88f9-1c62c938ad3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3233","original_object":"UniProtKB:P34969"}
{"id":"3e04a743-2bb9-4541-bc4b-f29ed306e081","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1550836","predicate":"biolink:affects","object":"NCBIGene:9170","sources":[{"id":"urn:uuid:9dc6efb0-1a30-4a86-a29f-9667f7cca022","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4031","original_object":"UniProtKB:Q9HBW0"}
{"id":"74754341-6932-4785-ba41-01dc0b5c724b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311375","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:a5b3c1d5-92ac-4b5a-846b-90fd7095937a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2016","original_object":"UniProtKB:P35346"}
{"id":"e32627f2-e1d6-4d54-a815-8975234314ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755254","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:f0327c0d-3da8-423a-85dc-09ed432b485f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6992","original_object":"UniProtKB:Q99500"}
{"id":"d93ecbd3-8781-4b48-acdb-44c4b7e8eca4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:124922","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:47f493ce-7d55-4460-9f2d-72e466517760","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8387","original_object":"UniProtKB:Q15910"}
{"id":"ab51411c-c5b8-4188-a3e7-143e6feabf5c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:6323","sources":[{"id":"urn:uuid:504c3832-a21b-45da-bcec-ced037d04a13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:P35498"}
{"id":"8ff77a34-c3b6-49c2-b2b0-7273ff5ff7df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10308720","predicate":"biolink:affects","object":"NCBIGene:12773","sources":[{"id":"urn:uuid:d813f0cc-4726-446a-8026-f07419df6923","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9678","original_object":"UniProtKB:P51680"}
{"id":"74812529-8b20-487d-b883-3a653e4e73cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35053","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:b64bfd71-7049-418b-999d-c40dfca34e70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2327","original_object":"UniProtKB:P70604"}
{"id":"9f470cad-d18e-4f70-ba1a-5183a5a2f415","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G786V328X6","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:8f026658-0132-4d4e-b2da-5db0e3a45995","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10451","original_object":"UniProtKB:Q08499"}
{"id":"a969fc60-05ad-4bf3-a8ef-77ecbe048757","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91326","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:546c9bee-dcb8-44d0-a168-5c385df1ca28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5662","original_object":"UniProtKB:Q00534"}
{"id":"0b6d931c-e4e7-46a0-b2b2-550540886e65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83536","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:41ed13d0-8638-49a5-8924-52d6f5607be2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:115","original_object":"UniProtKB:P28223"}
{"id":"59fb6ac4-10ba-4d0e-ad19-6dd046653696","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6950","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c73024ba-222d-42c9-97f5-3cee07960ac8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7241","original_object":"UniProtKB:P28335"}
{"id":"79b0516e-2755-4ea8-8d7e-d2d3f64f00ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:f67d06ef-b225-4ff7-83da-29cce42cb44e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q13547"}
{"id":"be1420b5-e9a5-4c3a-80a8-7bb307e2f53f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:f3e5a268-229f-457c-a519-2609f3958a6c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:Q96LB1"}
{"id":"29ea1606-4bb2-44c0-aafe-04870473a49a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:f2a5354b-75b7-480b-a106-b82865285800","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:P70597"}
{"id":"bca99a54-156f-4cde-beab-c23f95d5b019","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91938091","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:aa6ecbb7-0024-45b0-a376-cbf769eaba98","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5910","original_object":"UniProtKB:Q15077"}
{"id":"5f475033-26db-4802-9675-20c1e0d5fe85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6449854","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:71cb5556-8661-4634-8a94-6473f16dbf67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3325","original_object":"UniProtKB:Q15722"}
{"id":"60cdac0b-f76c-4af7-a102-38302ebd5b82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15811","predicate":"biolink:affects","object":"NCBIGene:2916","sources":[{"id":"urn:uuid:ec2b9872-d930-4ec9-8cd0-263e969f9156","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1411","original_object":"UniProtKB:O15303"}
{"id":"69d03574-49be-4ba0-b72a-64a02a47701d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:256208","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:69884ed3-58f1-4cdf-899b-ae1f8d43a513","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1592","original_object":"UniProtKB:Q8TDS4"}
{"id":"fff453c0-b852-43d0-9d27-3b0d936317ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1569","predicate":"biolink:affects","object":"NCBIGene:4923","sources":[{"id":"urn:uuid:c33b8888-c353-414a-9228-941388d4e374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1569","original_object":"UniProtKB:P30989"}
{"id":"cf105b29-2765-4f16-b911-ef5d8f83ea23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4KW1M48SHS","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:57d0f990-6850-447d-b5f3-52d484b8b201","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7733","original_object":"UniProtKB:Q13490"}
{"id":"562d7df5-375f-4307-9309-510984d3ea78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"UniProtKB:P30729","sources":[{"id":"urn:uuid:e048a4db-9762-480c-a67d-b7dbbabef119","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P30729"}
{"id":"b4210413-56da-4941-8990-8f7c487d30ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67495834","predicate":"biolink:affects","object":"NCBIGene:3320","sources":[{"id":"urn:uuid:65463e21-b2e5-4441-b685-48368b1082cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9260","original_object":"UniProtKB:P07900"}
{"id":"810a3fd0-8ab2-41aa-a0fc-2fb6d94633e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94449","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:9f9321a9-bccf-4b2b-9e53-b01d1b98c559","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7459","original_object":"UniProtKB:P20309"}
{"id":"f519e988-b88a-4840-92de-5cd32723b44a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:57369","sources":[{"id":"urn:uuid:e486f393-ea13-4d67-9eeb-89ebe929a88b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9UKL4"}
{"id":"1e14797e-d9cf-4afa-afcf-5ca2fb56d4fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918583","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:bed30db8-15db-48c2-8223-03e31dcfdeaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4257","original_object":"UniProtKB:P31644"}
{"id":"aa3c4bc5-efec-4b37-b2b4-698b31f77610","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:5140","sources":[{"id":"urn:uuid:f5e99d3f-7ae4-4396-b97f-62a1fc57643e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:Q13370"}
{"id":"b48c65f1-054c-4f47-8305-e2760ec4d4a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64098","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:83233165-2af9-4229-a517-29fee24fa75d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:499","original_object":"UniProtKB:P18089"}
{"id":"e11ff048-f829-4b99-bc95-d9e15a4f626e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2532","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:1681c8c1-41a4-43c3-a387-398f30edadc5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2532","original_object":"UniProtKB:Q02294"}
{"id":"2a8d75b9-7321-41c4-a69d-c2cadc403c3b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9953766","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:81913a01-a8e1-40d9-85a1-b46edd6c027f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:467","original_object":"UniProtKB:P0DMS8"}
{"id":"bce82ff3-bf61-459a-b154-08e06d002cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:3b5a0f93-de50-4df5-ae66-cbfa51932ddd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:Q9BX84"}
{"id":"66d6a9bf-097c-49f3-baa6-b6435641ee7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42638006","predicate":"biolink:affects","object":"NCBIGene:63873","sources":[{"id":"urn:uuid:0e4223e3-f046-42c7-a5a3-acd36caabd1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4105","original_object":"UniProtKB:Q9EPK8"}
{"id":"237b6b50-c998-448e-98d4-698432f635b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51141","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:16e2b657-28f6-46a5-8d8c-816ab3616e39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7109","original_object":"UniProtKB:P35368"}
{"id":"701b2b6c-f89a-44da-8cfb-460fed85f333","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92165","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:e8a5803c-65c8-4d39-b530-ea8a3582a55e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5959","original_object":"UniProtKB:P78527"}
{"id":"8a489ce4-3afa-443b-96e0-d7fe830910e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:52H8DB0TKX","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:87aeff53-5e67-44d3-8aba-ad37dc0a403a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3462","original_object":"UniProtKB:P25962"}
{"id":"4af6a0ba-c79f-4834-b2bf-aef72f5328c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2725220","predicate":"biolink:affects","object":"NCBIGene:16512","sources":[{"id":"urn:uuid:49e95692-7b31-4a9d-8151-75a22272a99d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7663","original_object":"UniProtKB:Q9WVJ0"}
{"id":"151e582b-f4ad-4b7b-a684-f289405d7131","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40629","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:780b04db-1de0-4a97-bab8-090fb737c705","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7643","original_object":"UniProtKB:P04626"}
{"id":"80ad89ab-9a57-4163-b853-c0096f815d60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:672296","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:18fa03cd-50dc-4f55-bf9b-58fa89c829ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6048","original_object":"UniProtKB:P12931"}
{"id":"4665b111-3c40-484d-9245-caf9608d4677","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9713","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:7390028e-c68d-45b8-9d50-94182f7c1a70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9713","original_object":"UniProtKB:P37173"}
{"id":"f9120828-bea5-4908-ba34-b02f4e5c1c71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91083","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:468d5325-e508-46b2-82bc-7b79d84ebf1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5056","original_object":"UniProtKB:P17948"}
{"id":"dbf923e0-70de-480f-8cb0-1c9c5ae8ed8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:775288c9-d30c-4b45-9a6f-dbd00b07d573","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P32304"}
{"id":"21054024-ab24-4135-977e-fc910dd063b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188730","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:8920a345-847a-4984-8cb7-7baf0dcda3ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1987","original_object":"UniProtKB:P21731"}
{"id":"ea4f5a73-5046-488e-8e78-1012f6bebcf4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6861534","predicate":"biolink:affects","object":"NCBIGene:1512","sources":[{"id":"urn:uuid:875d5c8d-eb20-4383-969f-afa3ee8bd59d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9550","original_object":"UniProtKB:P09668"}
{"id":"986e2ccd-9040-4dfd-aaf9-876570e90e9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6095","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:6a177ef3-e8a2-43d5-9973-a4191046709b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6095","original_object":"UniProtKB:Q62805"}
{"id":"b51e982b-7130-4f44-aa35-7594d3feba63","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:353174","sources":[{"id":"urn:uuid:8839ef43-78cd-4223-9b72-7118bd83e0e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q401N2"}
{"id":"313ab983-6a04-4cc7-ae76-16cd93c16878","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3624","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:fd46c669-6110-425d-bf05-d12ec919cceb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3624","original_object":"UniProtKB:P70555"}
{"id":"a2f24507-7cee-4eba-85d8-da373e39f0de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:895a4cb0-01fd-427a-8d1f-414839307a5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P35968"}
{"id":"53e3ebc8-30ec-4685-a3b1-027428a07c55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16196","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:9371b4b9-08f7-49a6-8a8d-6578385b3bf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1054","original_object":"UniProtKB:O14842"}
{"id":"abf41f24-0eb1-40be-bf69-78fbf9e9225d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918553","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:9c00d457-31db-4b3c-9604-fcd6a886fa55","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3235","original_object":"UniProtKB:P50406"}
{"id":"0f8cafdf-3cc7-4e59-8c0c-cd92e663df51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145704693","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:1b95f5e1-6625-47f9-9e84-08b135fbb9a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10751","original_object":"UniProtKB:Q03181"}
{"id":"1f28c244-f499-4d7e-85ee-68ee2a394f90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N7T15V1FUY","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:99adb061-1362-4f0a-a5c2-a54a4b1eee90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9272","original_object":"UniProtKB:P33032"}
{"id":"978c3ab0-cd3e-4f9b-a803-0fc2efd0bd73","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46179018","predicate":"biolink:affects","object":"NCBIGene:11040","sources":[{"id":"urn:uuid:a6da6475-f864-4973-a6e8-5c0c41171050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9367","original_object":"UniProtKB:Q9P1W9"}
{"id":"53372110-203f-4380-bc5e-359be8a200c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5546","predicate":"biolink:affects","object":"NCBIGene:12776","sources":[{"id":"urn:uuid:e90aee26-c792-4212-9d40-86c3bc71a210","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5546","original_object":"UniProtKB:P56484"}
{"id":"cc67fe7e-7b19-4b19-9ddf-ad724d6e3697","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:11c0d419-6967-4128-be07-b1cd873e4dde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P32305"}
{"id":"f6ba03c4-ef92-43ed-9d50-5f627e036922","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45560410","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:e950f0d0-f42f-4be9-a20f-d0a1c1e502cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9825","original_object":"UniProtKB:P28223"}
{"id":"c523cb6a-43f6-4789-9e26-a8bbfe03ed08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:447458","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:e18bf2ea-746b-4cbf-a609-4e64b029aee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2664","original_object":"UniProtKB:Q07869"}
{"id":"0db3c0c7-c166-4c71-a772-19b0995313e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433306","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:15b4a19c-98a5-40c9-9762-9a7325543430","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12804","original_object":"UniProtKB:Q13547"}
{"id":"dabd0239-4ab0-4d9a-a0ba-fb8182274ba4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:5ccfee4c-d2b0-477b-a6e7-7d34f8b6a089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:532","original_object":"UniProtKB:P08588"}
{"id":"51572f26-3001-41c9-98e9-53da88c6b296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4653","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:f6a8087d-849e-4f83-b01c-54e70e17554e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4807","original_object":"UniProtKB:Q99808"}
{"id":"c942d617-12c6-41f5-aada-7f9c86b38b25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P93RUU11P7","predicate":"biolink:affects","object":"NCBIGene:933","sources":[{"id":"urn:uuid:961a492f-97d8-4dd8-86a9-8cc41182dae9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8266","original_object":"UniProtKB:P20273"}
{"id":"9952a981-052a-48c1-ad97-9ffcbbbe9636","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5520","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:fe2b2207-e02b-4ba0-9d67-76ffdede5d0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3786","original_object":"UniProtKB:P30968"}
{"id":"5dd23c2f-6f58-48db-a5a1-3cea4e4b579b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61400","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:1259c29c-9d90-4a78-bf96-99ad92a84d16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9176","original_object":"UniProtKB:P51451"}
{"id":"9d41c922-d9c7-4a6d-9814-c876d02752dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126535127","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:8e647055-d31c-45a1-b8eb-ae3f499468c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12079","original_object":"UniProtKB:Q00534"}
{"id":"046acc0f-a535-4dcc-948e-1e3193ff1468","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15843","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:3e6d5fee-f466-472e-8242-5b2ca53882b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2391","original_object":"UniProtKB:O95069"}
{"id":"11e605c8-41ff-457a-a9a8-24fc0db65b19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:7121adbe-b308-437b-a616-77c416c830d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:P58406"}
{"id":"4d64bb3e-d134-4a8a-8c27-c2dce4d2249f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6605","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:739cf479-a70f-470b-b445-4128efa91f87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:17","original_object":"UniProtKB:P08908"}
{"id":"9399a49e-e66e-40ca-a842-fb70224a81e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7466","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:803a78b4-e3ca-4593-8b31-cc501f8596b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6949","original_object":"UniProtKB:P10275"}
{"id":"5cd55c78-73f1-48e9-90bb-a53013a34521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2684","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:f75bb982-c70b-4aa8-a008-70ff667387ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9658","original_object":"UniProtKB:P08172"}
{"id":"a9ac0b47-302f-41fb-82ab-ba7c930776f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53068973","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:103270c8-a435-49bc-95c8-0fee671b7015","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13662","original_object":"UniProtKB:P0DTD8"}
{"id":"ca66d726-41a7-4e75-ac0a-5162b3f59138","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:27991","predicate":"biolink:affects","object":"UniProtKB:P48974","sources":[{"id":"urn:uuid:e26da117-99fb-4091-9d22-5b81ba98c495","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2182","original_object":"UniProtKB:P48974"}
{"id":"01c8d571-fa3d-40bd-8dd3-b1d8075a050e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135939","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:d4597073-12b9-4952-bfef-8f19e9010b20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7472","original_object":"UniProtKB:P04775"}
{"id":"d4ff1b5d-b119-4292-b2c4-03944dc05009","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755254","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:cfcfaba6-d1e5-4627-b81f-9149fbda231c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6992","original_object":"UniProtKB:O95977"}
{"id":"9ff0c611-2b0f-45f7-9cfd-71b63b70055c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L3SK5KX24S","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:24819c94-a5c4-4db1-a224-f141c66ea497","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:276","original_object":"UniProtKB:P50406"}
{"id":"b0a55a7f-9bac-4d4f-b200-fc6682dd6df4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8982","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:d4e08a2a-3e93-4254-8cd1-edbbf2723fb4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8982","original_object":"UniProtKB:Q9Y5N1"}
{"id":"2c1abee4-a7f0-4403-84b9-5d42ead204e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47657","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:bc6715c7-0a2d-4da2-8d7c-399070de6349","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6962","original_object":"UniProtKB:Q07343"}
{"id":"cb149d62-2837-4d9a-8bb8-b8535b31089b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H8768UL06V","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:b2a9ebae-0d63-44ca-a273-355f94a3ee18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9409","original_object":"UniProtKB:P00533"}
{"id":"ec41985e-892e-47e2-9334-a995b5ca9f43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559100","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:c96c0c53-f991-4db4-8a9d-f84243aadf9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:219","original_object":"UniProtKB:P34969"}
{"id":"61108511-b6be-4be0-8a51-1ffeecf6d57b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83405","predicate":"biolink:affects","object":"NCBIGene:673","sources":[{"id":"urn:uuid:bb668da6-b75a-4d14-a243-05db8909647f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5681","original_object":"UniProtKB:P15056"}
{"id":"f1752c3a-681c-4b78-a3f1-4dcbc6cf3ce7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6179","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:e37d2724-14fd-46b6-8bbc-72338e84ce94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6179","original_object":"UniProtKB:P30550"}
{"id":"a687219a-145d-447a-9986-ecaf470bfeac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132947","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:a83efbec-fe06-4dc9-87f7-e09e036fd6cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:361","original_object":"UniProtKB:P20309"}
{"id":"f7dc084c-f1fe-4598-afd9-9591b22fa492","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:23606ac7-1536-44a1-acf9-c2294eab8978","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P35346"}
{"id":"960aaa85-0786-46b5-8f27-468040505edd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42977","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:c35565d9-041b-42b4-badd-6a01a32cbe3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2885","original_object":"UniProtKB:P51449"}
{"id":"a2b6f474-073e-4b36-9ded-9baeedee9823","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:6b5f8983-7770-46bd-8d1f-55456ba1b053","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P41595"}
{"id":"a10b883b-1a6b-4219-bb5b-963f51596a28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9954802","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:9498f64e-acf4-4009-808e-0aa44f6e2127","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2698","original_object":"UniProtKB:P37231"}
{"id":"c40249af-7234-46b4-b50b-c6ebca3d78a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60202321","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:88a3a4ac-ef1e-4daf-9ced-7d26b5e8ce82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6950","original_object":"UniProtKB:P56817"}
{"id":"01e31d14-f61c-49c5-ab8a-70e9279d3d70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75722","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:a1b0c0ff-993d-43d7-b65a-af8f0f650af5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8286","original_object":"UniProtKB:P41143"}
{"id":"6ddc4ced-1f45-4365-a7d0-fae2159744a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131502","predicate":"biolink:affects","object":"NCBIGene:19214","sources":[{"id":"urn:uuid:f58eeb64-a3e9-4343-885c-37f9473d51f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1878","original_object":"UniProtKB:P70263"}
{"id":"e340af7e-123c-48a6-9d72-d14d7d26a758","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10650","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:c4dd9c45-bb13-4a01-a0e7-97968765015a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:54","original_object":"UniProtKB:P30939"}
{"id":"2f6e1bcc-1e26-486f-8ce8-6c49830d74fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:a6e2b007-5513-460b-8f1a-5b0a78efa2c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P48167"}
{"id":"e685deef-735d-4fa5-aea0-dd0339012151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134726","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:c4b26ee2-f503-460b-abfa-b9ec4ac2f9f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5608","original_object":"UniProtKB:P25099"}
{"id":"595606d4-45de-4125-ad1b-b13ef6689d1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9506","predicate":"biolink:affects","object":"NCBIGene:78956","sources":[{"id":"urn:uuid:0a16e039-eb4c-49f9-92a3-0ffff772ffa5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2616","original_object":"UniProtKB:O08562"}
{"id":"e39774da-bb14-40d7-951f-9c61dec82574","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39548","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:76337f65-7f06-4bce-8138-1ff2d970a0f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2949","original_object":"UniProtKB:P51639"}
{"id":"e0e06ab0-e5b1-406b-b8e0-b7a017eca202","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6427057","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:ecbc7d8f-eae8-4617-b182-1ddc3509debd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2373","original_object":"UniProtKB:Q99572"}
{"id":"92ea7ee7-0096-4c30-ac05-357a021a4fe2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3901","predicate":"biolink:affects","object":"NCBIGene:17200","sources":[{"id":"urn:uuid:da5b9725-5623-42df-a550-48b9ae7de60c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1330","original_object":"UniProtKB:Q64326"}
{"id":"71fed3da-9f39-4c6a-b213-0f95bd59b709","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"NCBIGene:779","sources":[{"id":"urn:uuid:7ac6e5f2-1288-45d6-bf7b-823a0591f9e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:Q13698"}
{"id":"00db4381-17c8-4d53-a86a-832f215963e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:1969","sources":[{"id":"urn:uuid:a6b905a5-ea94-4ff2-82d6-c507478f91c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:P29317"}
{"id":"a8da02e5-1979-4fef-b9d8-28241bba1aed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:185785","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:fbe2f913-f782-4dde-a2d8-698841abc5e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9705","original_object":"UniProtKB:P21554"}
{"id":"6d24e772-98ad-4ba0-972f-f23bcddb04f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440621","predicate":"biolink:affects","object":"NCBIGene:4161","sources":[{"id":"urn:uuid:3960416f-6865-4f84-b09e-4403ae513c32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1325","original_object":"UniProtKB:P33032"}
{"id":"d1b7e27f-59d7-4ef3-9b17-7cd61ddb82bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2087","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:998a79ad-00d7-4a07-a951-419d35c7f2e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2087","original_object":"UniProtKB:P21452"}
{"id":"1062b523-c7dc-4f12-b293-9a3a99decffb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46866191","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:993c13ea-ba21-47e8-8f2f-382eab2629a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6209","original_object":"UniProtKB:Q13255"}
{"id":"f83d4d03-0345-4e6d-ac57-35f246c0cc61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42491","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:cbf8756b-6f3a-4564-9383-169f31f5da8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:409","original_object":"UniProtKB:P25099"}
{"id":"4b72d216-36e1-4576-a85a-ef152f6aeafe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:a09d62c5-43eb-4761-a251-7a1231084d2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:P31645"}
{"id":"90ce90e2-d108-426f-85f9-6022e99927ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36802","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:31e70f1d-e5be-4045-97d0-9af7848af297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7549","original_object":"UniProtKB:P35367"}
{"id":"7277f00b-d9cd-454b-871b-3c4ab2078521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135484064","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f90d1042-1f4a-4baf-a712-4be94cab225f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:390","original_object":"UniProtKB:P30542"}
{"id":"373936e8-a5d3-47f2-b033-5f454b0d07be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80240","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:1b8523a1-6247-43e5-9b00-3d4f1e0c111f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:989","original_object":"UniProtKB:P25101"}
{"id":"ef1b5e3a-f793-4de3-89d5-778a7aacdc1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146212008","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:7e918fd9-8162-4831-981f-50fd685c04fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13457","original_object":"UniProtKB:O00329"}
{"id":"141dc367-9b0f-46af-bea6-6ff43ebc41a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231087","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:bb8e1553-e398-4a44-a32b-21369f28cb7f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9626","original_object":"UniProtKB:Q00534"}
{"id":"aec3c2ed-62ca-41dc-abc8-9b17c6d69d48","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VFC23V742Z","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:707836ac-1c57-4f93-b41a-59f2c5a5f41c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1619","original_object":"UniProtKB:P34975"}
{"id":"7bc6c12d-3cc0-45be-b442-7c6ae104b411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:71JE0C439X","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:830c53c9-6a84-490a-8656-ed1e4a2b5a96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4228","original_object":"UniProtKB:Q8NER1"}
{"id":"bcd340a6-e560-492f-ab95-8b21710b8192","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:566","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:17dfb5c1-5d6b-42b5-831a-109f4dd0fcaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:566","original_object":"UniProtKB:P23416"}
{"id":"a600ee50-8ac2-45d9-84d5-4e7b051d6bd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3841","predicate":"biolink:affects","object":"NCBIGene:624","sources":[{"id":"urn:uuid:39a02a63-3601-427c-b2ed-afad182e234f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3841","original_object":"UniProtKB:P30411"}
{"id":"02bf75d3-b077-4c63-a106-e1a1551bf7b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94307","predicate":"biolink:affects","object":"NCBIGene:10919","sources":[{"id":"urn:uuid:fb9efeed-6296-4271-bee7-7a97bbd97b73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8389","original_object":"UniProtKB:Q96KQ7"}
{"id":"f101943d-890d-4b73-a3f5-40238749240c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:758","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:2bac715c-1054-437b-a2ff-6acdbf87f10e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:758","original_object":"UniProtKB:P51677"}
{"id":"076d5804-1d8c-44a3-92d3-847465f9491e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:101110542","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:7febaa45-db2e-4914-8bfb-d58b2b6e36db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1293","original_object":"UniProtKB:Q99705"}
{"id":"5a13c2e3-12d0-4086-80be-bc4e216bf35d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90686","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:8fabc940-19cd-4836-9822-98f6596f4d27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9376","original_object":"UniProtKB:O00329"}
{"id":"19e0e065-accf-4442-b200-8c67d3b694d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3XVL385Q0M","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:5d16a70e-a08b-42ee-8ec9-f719f28651e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7913","original_object":"UniProtKB:P52333"}
{"id":"2d7f9237-6ef8-454b-a965-95fbb0c9b6ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2381","predicate":"biolink:affects","object":"NCBIGene:16516","sources":[{"id":"urn:uuid:f2f38da4-37cc-4a8a-b8e4-8dcfd4a8a26a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2381","original_object":"UniProtKB:O88932"}
{"id":"cd064a50-9a95-4048-87e8-5e9a998b23f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:c39ebacd-a179-4300-9664-54db1c198190","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P30935"}
{"id":"51b9a3f3-5dd6-48f1-9599-74e47fa30e59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2066","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:fb0bf017-9b21-4fa8-94e9-869430c4cf66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2066","original_object":"UniProtKB:P31391"}
{"id":"4002f529-cbfb-445a-9347-2ea256833da5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:24473","sources":[{"id":"urn:uuid:38265478-d275-4c0c-b4cc-3da1da7e794b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P19327"}
{"id":"815c5de1-52b8-426a-af11-708a341799af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45302","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:bdd498ee-07df-43c1-b66c-a8bdb14ed348","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6023","original_object":"UniProtKB:P48736"}
{"id":"41b01101-8361-47b2-b5eb-65da9cadc129","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92965","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:167d4a59-81cd-4c9a-aa00-6142c9330abf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6282","original_object":"UniProtKB:P35414"}
{"id":"63dde2cc-a5e0-4a5b-a7f4-5a255ec60daf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993637","predicate":"biolink:affects","object":"NCBIGene:2146","sources":[{"id":"urn:uuid:847e2b35-1b45-4a80-b4c6-5912850d26f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12352","original_object":"UniProtKB:Q15910"}
{"id":"5976ccb3-6b9e-4bb7-9bd5-b90ef7a52fa2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:109556","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:54cbf5d3-4e7c-402a-94fd-d9bcbe5e24ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1611","original_object":"UniProtKB:P41143"}
{"id":"f18cf16e-1027-418b-81cd-23b8e6e7fedc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6254","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:6201e192-a99a-4532-afba-1bb9ef7343ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6254","original_object":"UniProtKB:P31421"}
{"id":"4550254f-8cdd-4b51-8071-0c081c1b223e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132709","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:85b8d7b2-af12-473b-9355-e8f87163dd59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1477","original_object":"UniProtKB:Q9GZQ6"}
{"id":"e2bba377-a57f-4626-a9df-ebf839715772","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91810","predicate":"biolink:affects","object":"NCBIGene:15562","sources":[{"id":"urn:uuid:342cdfe7-2b1b-47c4-9c48-2b2c8e0fedc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:245","original_object":"UniProtKB:P97288"}
{"id":"e368815f-4e06-4c7b-934f-3cc0cfa3d0c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132947","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:1405cf98-2e63-4045-bbfc-07478cec89d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:361","original_object":"UniProtKB:P08173"}
{"id":"c656d927-3fa5-4b6b-b8d2-c3d2dd1a25ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AYB44L739V","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:a7e2dea8-e339-4d23-a559-1a5d63173bb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1850","original_object":"UniProtKB:P25105"}
{"id":"b2ed73b2-5883-40f1-9bce-57da69979845","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94771","predicate":"biolink:affects","object":"NCBIGene:51564","sources":[{"id":"urn:uuid:a84289c7-ce48-4dd5-86da-fd8fce738600","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7503","original_object":"UniProtKB:Q8WUI4"}
{"id":"cb2fe232-4e48-47f9-b04f-009a4aae0289","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139533572","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:a526f8cb-abda-4493-81f2-c66a586a2c3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12249","original_object":"UniProtKB:P10721"}
{"id":"501be1a6-122c-41fd-8864-4c0b44456f9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5292","predicate":"biolink:affects","object":"NCBIGene:3326","sources":[{"id":"urn:uuid:0ee32167-04fa-463c-82e9-1e0b840edc3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9829","original_object":"UniProtKB:P08238"}
{"id":"448b370a-7a02-42e2-a1b4-3ed8d48f58c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11998","predicate":"biolink:affects","object":"NCBIGene:381853","sources":[{"id":"urn:uuid:28b689a0-383a-48e4-bc76-8a1a567174c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11998","original_object":"UniProtKB:Q0P543"}
{"id":"122e92a5-9b87-4685-b5eb-148d10d38293","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5327339","predicate":"biolink:affects","object":"NCBIGene:841","sources":[{"id":"urn:uuid:3070a5f7-a2a1-424d-a7cf-d02dca3559e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8628","original_object":"UniProtKB:Q14790"}
{"id":"64d12c61-3de7-4a66-9633-44db12569144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321162","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:3afee0e7-89b5-4834-af19-1a019c095fd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10181","original_object":"UniProtKB:P12931"}
{"id":"d774e589-7b66-4a64-b610-ffbc0e26a9d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93359","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:efb0855b-7255-4a8f-9054-8c1414529ada","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1255","original_object":"UniProtKB:P58406"}
{"id":"bb5f5120-64cc-4783-9c7b-f3de88b6a6b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49575","predicate":"biolink:affects","object":"NCBIGene:25570","sources":[{"id":"urn:uuid:3df2cdf5-2644-4d15-8677-27641888045b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3364","original_object":"UniProtKB:Q01717"}
{"id":"cec905de-8352-4090-a42c-f4bc6e58f4a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34727","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:5b6dc799-d1f0-4a73-a7e8-4b7caf15c619","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4181","original_object":"UniProtKB:Q13002"}
{"id":"e9cad1a0-3444-4b3a-9054-b159ad3a61a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817499","predicate":"biolink:affects","object":"NCBIGene:4142","sources":[{"id":"urn:uuid:6e3534b2-9790-4f50-9e8d-6213dfc581aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7040","original_object":"UniProtKB:P04201"}
{"id":"4bdc179b-a2a5-40ff-925d-0535fd169b13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4008","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:0bc8abc2-1add-4a7d-8329-adf5fe17f8fd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4008","original_object":"UniProtKB:Q9UGM1"}
{"id":"4de85a2b-7353-4574-8857-2f63b9f575ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185871","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:263af036-227a-4e65-b129-bd6edabace6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3284","original_object":"UniProtKB:P29275"}
{"id":"cbde7fba-9679-46c3-9e39-512b27212fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9352","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:521df573-1e44-490b-a619-0ab03ca94c0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5425","original_object":"UniProtKB:P19793"}
{"id":"9606891f-52ee-48a3-a48b-8f4b8fafa9c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168867731","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:7acc3fa4-c8e6-44b2-b896-406c9b8358f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12981","original_object":"UniProtKB:P00533"}
{"id":"d1475b9f-409f-45c1-959c-72151e89f9e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1041","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:6b03f474-6a79-4659-923a-f4ce0e1e4875","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1041","original_object":"UniProtKB:P25090"}
{"id":"7bffe46c-bb5c-4b65-b691-bd4cfcd9967f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6U9WP10T7","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:11c23d3f-32c3-4a89-9d5e-c2da6a219829","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7885","original_object":"UniProtKB:P35968"}
{"id":"3396c2a4-fdb5-47d7-96a9-457b66374d9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5818","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:42f2fe70-a728-441b-85c9-d48fe58c035b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7199","original_object":"UniProtKB:P35367"}
{"id":"4c04a838-0529-45cd-964f-9bd03c727cc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5O1LL04GJ3","predicate":"biolink:affects","object":"NCBIGene:57657","sources":[{"id":"urn:uuid:ef5ceb43-9519-4380-9ebc-4b4480b61039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2355","original_object":"UniProtKB:Q9P1Z3"}
{"id":"9fdf0340-fea7-4eca-b85b-fbf2dbc66837","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:33df87f4-a150-4428-86d4-5f5b4279d447","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P14416"}
{"id":"f94adc45-2110-4840-b14a-b8891663401e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31882","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:ceb6f264-6123-4cd0-8fa4-9e312d788781","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4268","original_object":"UniProtKB:O15399"}
{"id":"bdc41fe7-d36b-46fe-80cd-7eb01a19ae64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139030532","predicate":"biolink:affects","object":"NCBIGene:2494","sources":[{"id":"urn:uuid:6d099156-1553-4114-86ab-03a4c79b58d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10483","original_object":"UniProtKB:O00482"}
{"id":"f3d49aa2-f723-461d-beb0-87d9f6f1aea5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3897","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:839467c4-6609-4e4e-a06a-bd9dfba6b97f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3897","original_object":"UniProtKB:O43603"}
{"id":"91ab4d53-f5bc-49b2-a3c7-c252ce8f9b64","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755048","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:ff0d88fe-4c4b-494e-b9f4-aa1d4ef1e7b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3383","original_object":"UniProtKB:P25090"}
{"id":"ccd2b1b6-22fc-4a6a-9ac7-108ce2dca0b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2476","predicate":"biolink:affects","object":"NCBIGene:329954","sources":[{"id":"urn:uuid:0a01b121-00b4-4d0b-aa77-0e4aed4e31a9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2476","original_object":"UniProtKB:Q8BVN3"}
{"id":"1a3b9701-f6d2-4567-83cd-4df10bde4262","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10121975","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:8ec8a52a-6792-423d-9cdd-cedff5669c54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1318","original_object":"UniProtKB:Q99705"}
{"id":"0c2140a2-778d-41f3-914b-4bbaa2dd7a21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZET7B198W2","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:80e5ee3b-0e08-480a-aded-19d77145753e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:525","original_object":"UniProtKB:P18089"}
{"id":"8c55f094-2cf9-4bee-9a08-c6dcaed43dae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:3fcbf3ef-f868-44cf-8bef-54de63961db4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P08908"}
{"id":"86dc3d68-1f3a-4e11-9e5a-7ed8c22d7aa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1031","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:6fb0250c-b3f0-4a56-adcf-e123d1acb170","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1031","original_object":"UniProtKB:P33766"}
{"id":"04ee200d-3b60-469f-8f4a-70d4461e69e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221382","predicate":"biolink:affects","object":"NCBIGene:1508","sources":[{"id":"urn:uuid:2d2092b2-bdd1-425d-8565-408575d5eea4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10967","original_object":"UniProtKB:P07858"}
{"id":"89f46697-1a52-4559-b24f-7648303ec5c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1802","predicate":"biolink:affects","object":"NCBIGene:56813","sources":[{"id":"urn:uuid:e8a7d6fe-9629-4199-9471-98208fa25578","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1802","original_object":"UniProtKB:P25961"}
{"id":"e2ea63ad-a130-485b-baac-85560806ddf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1517","predicate":"biolink:affects","object":"NCBIGene:5467","sources":[{"id":"urn:uuid:fb6cc45e-20f2-43e2-87fd-95cf1c2ffad9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2716","original_object":"UniProtKB:Q03181"}
{"id":"e6b7cf2d-f084-48e5-8ac8-70d76a8a1589","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5852","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:66857748-7c4f-4b1a-86d8-64423231b23e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13148","original_object":"UniProtKB:P31645"}
{"id":"896e9011-57a6-45b1-8b33-1412e8fe52fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:71492GE1FX","predicate":"biolink:affects","object":"NCBIGene:3568","sources":[{"id":"urn:uuid:cd44143a-5d12-4b01-8874-98dfec48bf6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7674","original_object":"UniProtKB:Q01344"}
{"id":"2f247959-362a-43b7-b3fe-d3d7e1842f80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:1658896f-1b04-47f0-95fe-0fdddfc8926f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P50406"}
{"id":"09d410dc-21d4-4806-a252-8cd8ffa0629b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94411","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:4f4ac154-9855-4167-be82-b8c337d34b43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10470","original_object":"UniProtKB:P08172"}
{"id":"733e3453-f789-4cb0-aad7-e98f6d472331","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996511","predicate":"biolink:affects","object":"NCBIGene:2838","sources":[{"id":"urn:uuid:5dfc3c49-24d7-4139-85d2-5d8e2baa2399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10568","original_object":"UniProtKB:P49685"}
{"id":"2ca80956-e26e-4658-a4a4-93d518034a65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2339","predicate":"biolink:affects","object":"NCBIGene:304827","sources":[{"id":"urn:uuid:95c88925-24de-4fe0-8dbf-5f0665fdd354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2339","original_object":"UniProtKB:Q6UVM4"}
{"id":"14835e2e-04e3-43bf-825c-97e3c7ce539e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6GM6ZN5S1Y","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:a93c91b8-f3dd-4157-b083-749ea03a9976","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5868","original_object":"UniProtKB:Q92847"}
{"id":"651b7958-6ef0-446e-b504-2f9e843bc72b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2684","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:ed281dd0-ecac-4cca-9df2-2a5f4df8164f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9658","original_object":"UniProtKB:P11229"}
{"id":"897ee319-7b7c-42a7-9e85-be1faba3c4dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28593","predicate":"biolink:affects","object":"NCBIGene:157855","sources":[{"id":"urn:uuid:ae1582f4-fb7e-42fd-a4d1-85564184afae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2342","original_object":"UniProtKB:A8MYU2"}
{"id":"a63d234b-39e3-4fd4-80ae-4dcfae6eb93f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34732","predicate":"biolink:affects","object":"NCBIGene:116745","sources":[{"id":"urn:uuid:4929e254-d19c-43ae-bd26-5687075cd7f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2605","original_object":"UniProtKB:O54853"}
{"id":"b011052e-c9f7-45d5-b0b9-49a9087382d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132049","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:a9d0cc00-87c5-4ad6-962b-0ce3009ab12f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:180","original_object":"UniProtKB:P28223"}
{"id":"b4c41ef0-8104-46a2-bfd7-b32e2cd81caa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6103","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:0f5e770c-c1c4-43ef-866d-18f384ebecfa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6103","original_object":"UniProtKB:O43603"}
{"id":"905a4e4a-9ec7-4005-ab03-ea18fef9598c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:41879","predicate":"biolink:affects","object":"NCBIGene:2908","sources":[{"id":"urn:uuid:0207f6f3-bf61-4fe2-a341-7e05aac63d74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2768","original_object":"UniProtKB:P04150"}
{"id":"5d727de8-7ffa-4306-b9bc-19d27390c60b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T3U32GLJ0F","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:19443952-23c4-42fa-9cc4-77e3a1e48ba6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9776","original_object":"UniProtKB:Q08499"}
{"id":"9ee5724f-72b1-4ce1-8eb5-1aa0f159e74a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16725999","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:1b73226e-f245-4ead-babb-ca9de83aa9a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6985","original_object":"UniProtKB:Q9JL06"}
{"id":"f95785b5-67a2-4a4a-99c9-975056c999a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10500941","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:341da5f0-ef3a-4dbc-a8bd-1a2cb6120eec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:393","original_object":"UniProtKB:P0DMS8"}
{"id":"3fe014a1-f443-4e50-aef0-a1da67f432b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134693894","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:b468fc1b-eba0-469b-9f6e-0b136e3ea546","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10105","original_object":"UniProtKB:P00519"}
{"id":"c6adc551-cfda-45e0-a8e1-5e4395f0af5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131345","predicate":"biolink:affects","object":"NCBIGene:776","sources":[{"id":"urn:uuid:e19018c5-ce39-45b5-a63f-f90b07ecd63d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2511","original_object":"UniProtKB:Q01668"}
{"id":"0de1dacd-e63d-46fd-9258-6f0759b159e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50202","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:6507dd47-64c9-4666-8baf-53e5e099da51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:10298","original_object":"UniProtKB:Q9HCF6"}
{"id":"7afa4f86-c57a-4461-8653-942b5e2e21b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T6WM2IY2LM","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:f132f893-5335-4fd4-8cc2-f986ac944f02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6548","original_object":"UniProtKB:P09960"}
{"id":"391ac984-0b8d-44e5-9874-bf547d20e714","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63629","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:f9c993a2-cec4-4119-99d1-45daa686529e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7308","original_object":"UniProtKB:P08913"}
{"id":"b136ffe3-41e7-4f4e-a9fb-8c29af4d65cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817453","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:9a9cf84c-1737-4585-a953-554d0f49f561","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3763","original_object":"UniProtKB:P29371"}
{"id":"38705b72-670b-45b1-9429-412c9b35adb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5026","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:aa3964cf-f8ce-4c6e-af6d-61497e5aa53c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4318","original_object":"UniProtKB:Q13936"}
{"id":"79f07553-a55f-4aff-95cc-8c108b05bc1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9860294","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:49431b9b-5f64-4f13-b937-bb79a192268e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5613","original_object":"UniProtKB:P29275"}
{"id":"5e6f791e-0a7c-4ebc-a8d7-0af991359e41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:13878025","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:2571fba2-efd5-4941-b875-f22abb78026e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:184","original_object":"UniProtKB:P14842"}
{"id":"7d0a0cbe-eacb-4bce-8207-9e4113d81228","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8863","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:46bea024-7a21-418c-a177-3fc107626bc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2326","original_object":"UniProtKB:Q9UL62"}
{"id":"1c15f4d8-1056-4d54-ae84-ad8fb7ddcd0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145365","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:9715e671-6324-41b0-bab5-f13940ff40ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7882","original_object":"UniProtKB:P10721"}
{"id":"f7772b7d-8fd3-4935-9ad5-2d12f1f6f63c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OE1QTY7C25","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:81a671ba-dea1-4c06-b6bc-b12bd3032bfc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10631","original_object":"UniProtKB:P23458"}
{"id":"be0386e9-e95d-40a8-8c74-d4b307b98a36","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817480","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:adc1567d-8713-4b93-93c4-9480cdb2d69f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6091","original_object":"UniProtKB:O08726"}
{"id":"d0de035d-627d-4454-8a5d-467daa729b80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:66B7UY5K7I","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:d112b8b6-9e35-49f4-95c5-fc2563a23f6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7683","original_object":"UniProtKB:P35462"}
{"id":"a0adcc37-1d36-4a8e-ac76-10507e753e06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7577","predicate":"biolink:affects","object":"NCBIGene:775","sources":[{"id":"urn:uuid:00f91ddd-c14d-4dfe-8e29-cbfcf2b94f32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2524","original_object":"UniProtKB:Q13936"}
{"id":"c775b858-5814-4833-8653-eef7dddca4a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2208","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:6f4a1573-cf6f-414b-81ea-faf4f8011b84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2208","original_object":"UniProtKB:P37288"}
{"id":"82316ee3-4918-4f0c-8488-eb45699a37f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4KW1M48SHS","predicate":"biolink:affects","object":"NCBIGene:79444","sources":[{"id":"urn:uuid:b5ada9ee-28a7-4a22-897c-e0571b40fcfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7733","original_object":"UniProtKB:Q96CA5"}
{"id":"4ba8dac4-cfd5-46e5-9331-347079293851","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68595","predicate":"biolink:affects","object":"NCBIGene:1990","sources":[{"id":"urn:uuid:3257064c-984a-40ec-af51-34356ef8755b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7871","original_object":"UniProtKB:Q9UNI1"}
{"id":"6846cd7e-7dce-46b3-85ae-524af2016eb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:159547","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:7db10261-4270-4d3b-80eb-67abcc30f7d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1855","original_object":"UniProtKB:P25105"}
{"id":"c6edbc9a-edbb-4ef3-a7b4-68dff76ed676","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90656796","predicate":"biolink:affects","object":"NCBIGene:5641","sources":[{"id":"urn:uuid:0a9d6a6e-dba5-485f-b82c-33131dfe68cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8633","original_object":"UniProtKB:Q99538"}
{"id":"0792bd33-7d44-4312-9323-f6d6e8416397","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:917","predicate":"biolink:affects","object":"NCBIGene:1394","sources":[{"id":"urn:uuid:5e25b0b5-2f37-439a-bf0c-c2c6a1967476","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:917","original_object":"UniProtKB:P34998"}
{"id":"98f9deb7-dc62-4aeb-933e-4d30a686c9a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130339268","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:c3d14a02-fe09-4230-849d-48f798c2e9b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11613","original_object":"UniProtKB:O60674"}
{"id":"1d66a231-89b4-46a5-b840-1c5c0e381c1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92621","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:e9ff6896-afa0-41ed-af68-ac32b4295e21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:547","original_object":"UniProtKB:P07550"}
{"id":"8c53a900-82e9-4b73-bdfa-ee25196226e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:628c2e94-2a21-4c4e-bfad-79fab1053024","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q9UBN4"}
{"id":"12a481e0-e8ee-4f45-b8f0-97af9c247724","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:68551","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:cee852ee-b8f0-4d7e-9267-ad9a2d8d39b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5017","original_object":"UniProtKB:P25092"}
{"id":"34a0e12b-8b7d-401a-aac9-4bb4fae281d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:895OJP78MJ","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:22998fc4-7d5e-43e4-92c2-3c996c89b8d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:968","original_object":"UniProtKB:P35462"}
{"id":"8983aff0-e0c0-4a82-be28-540ceb04aa8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9139","predicate":"biolink:affects","object":"NCBIGene:10057","sources":[{"id":"urn:uuid:73d1c523-02c5-4a19-97f3-ff653d2cbd72","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4743","original_object":"UniProtKB:O15440"}
{"id":"f5179945-1926-4764-900c-b10461b6fc2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:5584","sources":[{"id":"urn:uuid:3c03298b-5f71-4445-9815-4424761835ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P41743"}
{"id":"6825aafa-ba95-4ea1-991b-debbd9b09661","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49872868","predicate":"biolink:affects","object":"NCBIGene:1557","sources":[{"id":"urn:uuid:a1b98f26-cfb8-4e76-9544-60b34b278b3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8777","original_object":"UniProtKB:P33261"}
{"id":"ea46d56e-2c17-4e0a-a098-248947248980","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6219","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:e26fb6f4-c7dc-40a7-8d18-9ce9dd8f6384","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6219","original_object":"UniProtKB:P31421"}
{"id":"6dc69526-9652-461f-a234-5feb9a70bf8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15729","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:42b63142-b86f-4f70-ac87-8f88ca9f23c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:725","original_object":"UniProtKB:Q5T6X5"}
{"id":"c9a06962-edaa-4299-bdb5-0acfe5371669","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11677079","predicate":"biolink:affects","object":"NCBIGene:157","sources":[{"id":"urn:uuid:c1a46b4e-2acd-48a8-b5c3-417a8cc5246b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8437","original_object":"UniProtKB:P35626"}
{"id":"83178d65-0efc-41e4-b2eb-0d8633930d4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50169","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:17605d3e-d713-4168-9772-4f89491dc433","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4108","original_object":"UniProtKB:P14867"}
{"id":"593854ad-3285-4170-b18d-39792cff2d7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O3MCV749SW","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:e6df06e9-59a1-4d58-adc9-f88367a5e8a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1857","original_object":"UniProtKB:P25105"}
{"id":"7253be95-d020-4b7a-8901-8eb0205b43d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947057","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:af8faa71-7731-464b-a19d-5bb0398b714f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2959","original_object":"UniProtKB:P51639"}
{"id":"a55f66d9-564b-428f-a969-e7eaee72e949","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10449757","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:09c34018-4493-4987-8735-f45fe27e0d86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:190","original_object":"UniProtKB:P28335"}
{"id":"aee87418-2156-438f-8830-a452e94c68ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:42519285","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:84405e7e-d315-4ca2-848b-2f72def0e8f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8591","original_object":"UniProtKB:P20309"}
{"id":"f7df2723-64a3-418f-b3cd-efe511fc8640","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:87056175","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:fcc11ecd-59a0-4132-8a02-b7a9c56e56b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13201","original_object":"UniProtKB:P00533"}
{"id":"c0f7c4e2-c7e1-41ce-840e-b88b8f40ecd9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56675928","predicate":"biolink:affects","object":"NCBIGene:3932","sources":[{"id":"urn:uuid:7d127e2f-01ec-42dd-94a8-a5adea7030a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8186","original_object":"UniProtKB:P06239"}
{"id":"62523236-d609-4aa0-9281-0e66a8381aec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:85ffccbb-a9ca-49eb-b190-eb55306f949d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P11362"}
{"id":"b79f81b1-d753-4f60-a8f1-96fad6738c23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11648276","predicate":"biolink:affects","object":"NCBIGene:63885","sources":[{"id":"urn:uuid:33b02b5e-8caf-41e4-ab49-072deef39eb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13575","original_object":"UniProtKB:Q9QYJ6"}
{"id":"62ce12a8-3899-4e82-bf48-28981dd7d090","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4787937","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:365bd790-7f72-4588-a54e-4ac4815e582d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7846","original_object":"UniProtKB:Q12879"}
{"id":"548a4332-9879-4c9f-bcef-8b53c3a85bfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130452","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:71d50c08-1a5a-4a74-be50-5bc6752d38b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3556","original_object":"UniProtKB:P35414"}
{"id":"2d3cb147-ae68-47cd-be3d-0f9f41624255","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2190","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:cf427d4c-9ec3-44d3-9322-cd01212dd319","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2190","original_object":"UniProtKB:P30518"}
{"id":"eefb529b-f886-40f2-aa52-9a46d0499f0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2096","predicate":"biolink:affects","object":"NCBIGene:24807","sources":[{"id":"urn:uuid:7b782688-fbf0-4a99-8b66-7bb2df451847","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2096","original_object":"UniProtKB:P14600"}
{"id":"38702804-26fe-4778-b71a-5f477c26aa9a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111173","predicate":"biolink:affects","object":"NCBIGene:5142","sources":[{"id":"urn:uuid:68b18d56-78f4-4b03-ae3d-3ccc7a12b018","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5258","original_object":"UniProtKB:Q07343"}
{"id":"7f8698c6-d99b-4674-ad06-aa00a35db458","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87283","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:c9b04713-e610-488d-bf2c-fa8b164b7a94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9371","original_object":"UniProtKB:P00533"}
{"id":"67f930eb-cd88-43c3-9e50-79e19de96cb6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL2219823","predicate":"biolink:affects","object":"NCBIGene:4047","sources":[{"id":"urn:uuid:b0288291-1f2f-42e6-ab28-14347c04853c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6714","original_object":"UniProtKB:P48449"}
{"id":"c211a2ec-c68a-4ea6-bdce-5e492701ba43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:1760","sources":[{"id":"urn:uuid:36f88c83-c959-4d41-b9b5-249763e4aaa0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:Q09013"}
{"id":"2ab0b29e-f951-418d-bcf7-9f819af50ba3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755159","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:ff04bbb8-0854-4f80-a96a-c475a97a826a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5823","original_object":"UniProtKB:P30557"}
{"id":"deb1354b-0740-40a3-83f1-0999ecb341b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5277GPA358","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:ef26b2b8-10ad-4557-a6a0-0ffa59f0b8d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9927","original_object":"UniProtKB:P35968"}
{"id":"347c54ef-7010-4260-8d13-f35ae493ec26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156760414","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:8ebc2b8d-8adf-4a3c-b0a2-7a65e883da47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13445","original_object":"UniProtKB:Q99685"}
{"id":"c8814bcd-e8d2-4c11-82f3-2cf533868618","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16796","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:d4b5397a-6d5d-4dec-a9ba-1fae265a25c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:224","original_object":"UniProtKB:P49286"}
{"id":"8a351394-b29d-46a5-9ffd-9baddb25bef9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8734","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:e050465d-9996-4617-870d-738faedde312","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1372","original_object":"UniProtKB:P31424"}
{"id":"4fd382aa-67bb-4a1d-91e3-402593ed52fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FA554TW3UP","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:02c98fec-7ccd-415d-be4a-1b9c4898629b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9004","original_object":"UniProtKB:P41145"}
{"id":"a8186000-fe1a-476a-bdd1-391450b99da2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15422","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:9a64c9cf-7af9-47bf-a1b2-7066853eceb3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1713","original_object":"UniProtKB:Q8TD43"}
{"id":"6fd5d1be-3325-412f-8192-c48a6c6d9fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:441P620G3P","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:984b99cc-f36d-414d-95dc-8a26c97c85c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9426","original_object":"UniProtKB:Q92769"}
{"id":"dc28b775-8bcc-42ff-96bd-305ca620874e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11397050","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:f756c3fe-3349-4ae9-a268-2d4adeab8d93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9264","original_object":"UniProtKB:Q06187"}
{"id":"aefbd8b8-828a-46de-93a1-27598ed41e38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78543","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:259787cd-6097-4452-8e66-d734d3448927","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5890","original_object":"UniProtKB:O43353"}
{"id":"dfeff107-6efb-4334-b2a6-d2b3cf3b888e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NR72W2V70N","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:5541e378-7649-440d-9660-52dc213f568a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2107","original_object":"UniProtKB:P25103"}
{"id":"b2190dbd-8875-4b95-a233-f7d69d14f6f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946093","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:59221dff-9c40-45d8-8900-8c61b0fc96ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10598","original_object":"UniProtKB:O00329"}
{"id":"900898a4-a423-42c0-836f-b3d7cef3d3df","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34373","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:27cf5b57-d38c-4fbc-93e4-c6aa33ff2d51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4322","original_object":"UniProtKB:P47869"}
{"id":"7ab3b2a3-6b78-4bd9-b8fb-563f690bb11a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32193","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:6cf2bb48-4f49-47b3-97bc-b243f211ee19","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:56","original_object":"UniProtKB:P35348"}
{"id":"6f3ac709-2575-4058-bd92-ef89db6e7b57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:9d04482f-0b23-45ff-9f7f-08d84c98e48f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P41595"}
{"id":"18b264dc-4cd9-4005-9b7d-9fa6e7864a01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24868177","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:556e25c8-68e0-453e-8501-8aa5823e23da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1504","original_object":"UniProtKB:P21555"}
{"id":"8afc8de6-281b-4311-8be5-e2eb93667431","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EW83PST7OQ","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:c08099ae-f330-47b0-8720-6d005671c77f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:945","original_object":"UniProtKB:P21728"}
{"id":"2be11fbb-6515-41cc-94d4-78e6fdab2580","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3847","predicate":"biolink:affects","object":"NCBIGene:381853","sources":[{"id":"urn:uuid:16254df7-8a97-4252-ab5c-75a118ac0881","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3847","original_object":"UniProtKB:Q0P543"}
{"id":"f32548c0-9f61-4f8e-ae76-f03a0dd9a5c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92998","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:b46502b5-a121-4289-90aa-8cc279600617","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5443","original_object":"UniProtKB:P18825"}
{"id":"72216b92-2f93-474a-9b13-290d7c24eae1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155491009","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:e25744f0-1aef-43f9-b08a-936e4ec379ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11447","original_object":"UniProtKB:O43614"}
{"id":"502934ca-1df4-40b2-b64a-4ce6db725b00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25023861","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:ded950bc-0e2b-4813-9a12-ae4353e67259","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3194","original_object":"UniProtKB:O95749"}
{"id":"4a789f20-702b-4178-93a0-7f2f318908b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10188","predicate":"biolink:affects","object":"NCBIGene:364","sources":[{"id":"urn:uuid:b33a9fc5-21d8-4bf4-b6e6-2bc09e497941","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10188","original_object":"UniProtKB:O14520"}
{"id":"1ca5fb75-9ae5-417c-854c-b0ee4aad4317","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:130339268","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:2ca04dca-2882-4ec9-9277-366c770e94c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11613","original_object":"UniProtKB:P29597"}
{"id":"f251bcd4-3423-4daf-8e01-4e438f1489da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1GAJ98SC2X","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:99f190f3-ea1a-4c19-a59b-654a951dbb58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7744","original_object":"UniProtKB:P49841"}
{"id":"737ee142-36eb-4b7d-ac1a-a3bbfc9d8def","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67161540","predicate":"biolink:affects","object":"NCBIGene:8491","sources":[{"id":"urn:uuid:85220b9a-69c2-44c1-b56d-88afb023a151","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8175","original_object":"UniProtKB:Q8IVH8"}
{"id":"19b9047c-b458-48e6-a300-6625bdd47c7c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817463","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:2dd40dc8-685c-4530-907b-5f2c482f1d3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3861","original_object":"UniProtKB:O43603"}
{"id":"23cde58f-d3a6-4cdf-99c1-a2652fcb3de8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185382","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:4b2317d3-1c22-439e-bc58-93273dfd6d15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3120","original_object":"UniProtKB:P37268"}
{"id":"b2e39ed1-cdff-4850-b450-7581391307f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2320735","predicate":"biolink:affects","object":"NCBIGene:5025","sources":[{"id":"urn:uuid:b75b1968-a967-4a36-a874-95951835b525","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9542","original_object":"UniProtKB:Q99571"}
{"id":"9da934d8-6d3d-4cc8-b328-2b7611349480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:4ed311c0-40b5-433d-a824-6f849f5c7667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P43117"}
{"id":"b98c7781-ca90-43bb-8f1a-617cfc7862e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:141346","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:3ee6a993-513d-48e7-bec9-5067b156853c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9512","original_object":"UniProtKB:P08588"}
{"id":"c64b2baf-ba32-47a2-ad5a-ff4cc3637a72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311196","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:fe0a810f-026d-41fe-8dd2-60f25b3a17e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3888","original_object":"UniProtKB:P32238"}
{"id":"a1df12e8-dc54-4917-8d2c-75baaa83fc27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8543","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:63403995-cd49-4d1f-a2ee-be588214ed08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8543","original_object":"UniProtKB:P31424"}
{"id":"b52ac76e-d386-430d-bece-446eed5296d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23056","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:225b806b-a6ce-4e18-8b9c-89a57520e2f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:318","original_object":"UniProtKB:P08912"}
{"id":"3796bae6-0b6b-4f7b-b47b-13a579bda98a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5478838","predicate":"biolink:affects","object":"NCBIGene:290","sources":[{"id":"urn:uuid:5fa79f19-c129-47ac-9d8d-f79f8dc19183","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9091","original_object":"UniProtKB:P15144"}
{"id":"576ade8c-f0aa-4538-8cb9-4f70e7c8bd5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126619980","predicate":"biolink:affects","object":"NCBIGene:8019","sources":[{"id":"urn:uuid:9c429de0-111b-463a-a97f-e5184a193038","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10564","original_object":"UniProtKB:Q15059"}
{"id":"f73f8da4-5d52-464d-b656-9d8d7551e70e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79990","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:8b9659a9-89da-4eb5-a320-e69d6d134ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2656","original_object":"UniProtKB:Q07869"}
{"id":"ccf6a7ab-f230-4235-8c58-04fa95388eab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:17757384","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:b2efbc38-334e-482c-a3a7-c34e4b2242d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4120","original_object":"UniProtKB:Q8NER1"}
{"id":"9666ae3c-d7d5-44a3-97f4-432d10c47370","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131180","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:4f1cabde-e746-475a-89ce-38689f61d24b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:567","original_object":"UniProtKB:P25962"}
{"id":"e0a8bfef-bc60-4817-a3fd-84f19672d84c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93418","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:8cafab7f-0fdc-44bb-9913-5f097f4f4b5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3232","original_object":"UniProtKB:P50406"}
{"id":"e47b5882-38f5-4329-b515-836a45389d31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11526708","predicate":"biolink:affects","object":"NCBIGene:80142","sources":[{"id":"urn:uuid:7e3623f3-adba-4002-8364-048e51fcff61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8812","original_object":"UniProtKB:Q9H7Z7"}
{"id":"26d0ead1-b2c4-4911-a4e0-bcbafe41a467","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:92135967","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:e59561f5-d0b4-4c34-a12a-f9745fa5b297","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12087","original_object":"UniProtKB:P04629"}
{"id":"3fbfbfb3-98c9-49ad-92dd-6350fb07d83a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17780","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:b6ad8595-1235-4691-be8e-0fff28c08b8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4671","original_object":"UniProtKB:Q7Z2H8"}
{"id":"485a3703-1461-4cea-929a-5388dcb3173c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34507","predicate":"biolink:affects","object":"NCBIGene:55107","sources":[{"id":"urn:uuid:6b325a37-b4a9-4564-a014-3f84990df32d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4113","original_object":"UniProtKB:Q5XXA6"}
{"id":"3643a9cf-e6a3-4a6f-a38a-29b772d7c49d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25240297","predicate":"biolink:affects","object":"NCBIGene:78976","sources":[{"id":"urn:uuid:d47351de-3be6-4db0-9cef-9d34303cdb3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1283","original_object":"UniProtKB:Q924U1"}
{"id":"0cb710d5-0b22-4654-b0a2-653ab6cd8ed8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10093","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:ab7af393-131d-48b3-abd9-6d51356ad0a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:102","original_object":"UniProtKB:P28222"}
{"id":"8168df2a-fb9f-4097-be8a-d7f552bd4216","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17574","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:9fbc17ee-3baa-468a-bcd3-84d9d5e65325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2829","original_object":"UniProtKB:P62508"}
{"id":"809a0304-16c2-4b3a-9654-570f737122a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10864183","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:58169894-d144-48ca-9c74-269ecc7cbcb5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9838","original_object":"UniProtKB:P35372"}
{"id":"12aafa65-d230-4f01-a7a9-5c536a175de5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9840090","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:8073b4ad-b1ff-4142-81b6-589704b8eeac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:157","original_object":"UniProtKB:P28335"}
{"id":"76cb232a-4772-46f4-85f5-1c518ab38deb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59548652","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:5499cee3-c976-4175-9eeb-58d4fcbe0b4b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6428","original_object":"UniProtKB:P41594"}
{"id":"8e72a663-c9f1-4540-9b31-c756c60fd5ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5862","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:05f6e735-2d91-43bf-8713-21ea2f52e892","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12575","original_object":"UniProtKB:P18089"}
{"id":"ee64a019-5514-45a8-ae06-78c011b257ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:2964bd70-55d0-40dd-8eee-8d2f515adc4f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P41145"}
{"id":"7ae3f3f6-8e24-48dd-877f-df8439f2e057","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7ON53PV45J","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:c36de3af-590b-409a-9ca8-aaaaecfcc9d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13016","original_object":"UniProtKB:P25101"}
{"id":"adb96294-f9f3-4603-ade9-d22eff52f440","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LPN433P0EA","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:8ea13886-d597-4c4b-b05a-39f199d332b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10045","original_object":"UniProtKB:P51449"}
{"id":"ccfd1b58-a1ac-417d-8679-b07507c0d3de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92263","predicate":"biolink:affects","object":"NCBIGene:2554","sources":[{"id":"urn:uuid:b4d87c18-8188-446c-b7fc-41701423b1d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4179","original_object":"UniProtKB:P14867"}
{"id":"5a3b1c30-a656-4b97-96e1-a9c2b190e959","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:90de4c03-4aa9-4577-ab70-013024b06839","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P34980"}
{"id":"ea2b14c8-817a-4311-bd0c-1cf062d8d3fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118016229","predicate":"biolink:affects","object":"NCBIGene:29316","sources":[{"id":"urn:uuid:b903640b-333a-417a-8153-bb247dc27e6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11224","original_object":"UniProtKB:P29276"}
{"id":"669ed31a-f864-47da-8756-7ff64aa83a5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9445","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:850f39e9-c19a-4249-98f6-8860321471d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7302","original_object":"UniProtKB:P35348"}
{"id":"f4694c97-a246-4654-a4a5-a304dc5e3783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74765859","predicate":"biolink:affects","object":"NCBIGene:10741","sources":[{"id":"urn:uuid:6d86f8f7-3ec9-4d2e-9ffc-83d27d3c232c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8607","original_object":"UniProtKB:O75884"}
{"id":"6e3e86f7-3153-41e3-aeb6-fa0591efe735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:835","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:35c979e1-7e47-4144-b640-0952c1184090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:835","original_object":"UniProtKB:P49682"}
{"id":"19267a6d-90b6-43c7-8cd9-73b26f73190a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:c138c528-f9d9-4575-a44a-30c3d243c2b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P12931"}
{"id":"bab600f7-e24a-4b21-9d9d-4121a37d0650","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10904818","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:4559aa1f-f307-4511-84ec-1e9b3e0a712e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2937","original_object":"UniProtKB:Q99500"}
{"id":"e49d1c77-8466-4548-a11e-e83df71e9da3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4615193","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:37153542-670f-4722-9a61-cad8265321bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4141","original_object":"UniProtKB:P42261"}
{"id":"6d131e6b-1ebf-4520-bd7b-30e61325bf7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2709","sources":[{"id":"urn:uuid:434f3c31-e49f-46ab-a76b-2f330f096ada","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:O95377"}
{"id":"5b1f8506-019b-4532-bc08-23c154103d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437074","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:b77834f2-e726-43c4-9023-4b655153961b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1980","original_object":"UniProtKB:P21731"}
{"id":"22c24546-74fa-4f9d-b415-3ddccf477d28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110160","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:2875b1c0-571c-4112-81f7-91045bebfab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1358","original_object":"UniProtKB:P48039"}
{"id":"de0e945d-a72f-475b-8ded-09aefba82e4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16998","predicate":"biolink:affects","object":"NCBIGene:8843","sources":[{"id":"urn:uuid:ce0e22a8-e9a2-4a22-8e2c-3fa2b448a6e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5797","original_object":"UniProtKB:P49019"}
{"id":"a8bd9080-7f94-4320-b0e7-cd41bbbe150a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122173995","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:483574f9-813b-4d60-874f-f73661f16d51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9301","original_object":"UniProtKB:P10721"}
{"id":"6419557a-a037-4019-9b44-9e6550153a06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72722131","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:0419a352-f610-4a31-8536-33f5787295d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12521","original_object":"UniProtKB:P35408"}
{"id":"5c3f634e-94b2-4914-b7f0-551c8ab05aac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56593118","predicate":"biolink:affects","object":"NCBIGene:10434","sources":[{"id":"urn:uuid:58da44d1-38ed-45c2-be6b-3aa8e001aa92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13415","original_object":"UniProtKB:O75608"}
{"id":"0eb98392-13cc-46b5-9d45-6dea0c92f970","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95001","predicate":"biolink:affects","object":"NCBIGene:1071","sources":[{"id":"urn:uuid:5582fac5-9f3f-45e0-85d1-01df1dd8737c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12972","original_object":"UniProtKB:P11597"}
{"id":"33553e76-eca9-4c66-9b48-19714a7cf12f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134764","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:bec1757f-cd1a-4c58-96b2-16797a8df62b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:299","original_object":"UniProtKB:P11229"}
{"id":"f1345f33-72a7-4e5e-b27c-79a9d94f3283","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2552","predicate":"biolink:affects","object":"NCBIGene:16495","sources":[{"id":"urn:uuid:ca1785be-7eea-431b-9135-fa8d6dfb8061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2552","original_object":"UniProtKB:Q17ST2"}
{"id":"88fc7ac3-dbb3-471c-b0ef-c6ba758474d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177609","predicate":"biolink:affects","object":"NCBIGene:18671","sources":[{"id":"urn:uuid:e473609e-061f-49c5-bc42-b91a8d4d32d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11787","original_object":"UniProtKB:P21447"}
{"id":"db2d235c-b10e-404f-91d4-d40d1818363a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277836","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:e665bd92-84d2-4a39-89fc-dca2db1e787e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7770","original_object":"UniProtKB:P48039"}
{"id":"3c38bfc7-ad3f-4a42-9a13-88b6dceeceb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I7Z38E70VF","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:e97744e9-b771-4c60-ba0d-fe81091bd747","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5817","original_object":"UniProtKB:P43116"}
{"id":"20c9b5fe-c3e6-4116-b96c-31292210ec39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2550","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:5d282e25-4bd6-4114-b78d-531e43d718c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2550","original_object":"UniProtKB:P63142"}
{"id":"98fc0141-5f94-4487-8fd6-501b7dc0ed32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9386","predicate":"biolink:affects","object":"NCBIGene:3643","sources":[{"id":"urn:uuid:fcf0afd0-8b2c-4576-8d81-ddfa516dc48e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9386","original_object":"UniProtKB:P06213"}
{"id":"435b42dc-60bf-4d7c-b74f-532955d3b9ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91845","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:61fff9db-90a9-46eb-8a7e-e9f593f6c411","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:53","original_object":"UniProtKB:P08908"}
{"id":"263ff874-4278-4d18-9664-4227eec85aae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:d9eff789-27f1-454d-b798-e484a247f669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P43115"}
{"id":"604f8d5c-5a74-4482-bafa-4aed5fac8ddd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:YTL7A418KQ","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:0894a656-ab6e-48fa-b4a5-c825c62408cf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8391","original_object":"UniProtKB:Q9UBN7"}
{"id":"765551c3-ab64-4934-9e57-652ba86c6c7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755251","predicate":"biolink:affects","object":"NCBIGene:65086","sources":[{"id":"urn:uuid:5876efb3-66f2-489e-9cb1-5ba3c7d3461e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6983","original_object":"UniProtKB:Q9EQ31"}
{"id":"2d1d2604-237d-48d3-803d-b2a576514dca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177398","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:b597c8b8-ac52-47a2-aef0-fb452e6ac767","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5605","original_object":"UniProtKB:P0DMS8"}
{"id":"418b3eaf-51b4-40d3-9e37-72e771e0ef7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9972691","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:a1766a41-09f8-495a-a500-a6acaa0938f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3418","original_object":"UniProtKB:P31424"}
{"id":"af27d1a4-5f8e-4bcc-90ff-55c56d3e540a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9549284","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:0a761fb6-2050-4b58-a6d7-2defc7bc9d73","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6008","original_object":"UniProtKB:P36507"}
{"id":"9deb4df0-fb58-4c4b-8618-719dc5e00083","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230107","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:31b71930-3686-45d8-8e43-7c62b3e14984","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1633","original_object":"UniProtKB:P41143"}
{"id":"20d49cab-46d7-400b-b8a0-72dcc8eb3710","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:49d45d3a-940b-4b26-b10e-d0a5437aeb0a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P32305"}
{"id":"be46f209-c808-4241-bd5a-b45467ecaf60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QB6LNL4NF6","predicate":"biolink:affects","object":"NCBIGene:11200","sources":[{"id":"urn:uuid:c20cf9ea-b68e-4e12-ac73-3fd2c65309d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9187","original_object":"UniProtKB:O96017"}
{"id":"5bdbbbeb-e0cf-4fca-bdcd-8c7ef706282b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:773","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:739e6e6e-8b70-4038-8323-db9f88f71c3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:773","original_object":"UniProtKB:P61073"}
{"id":"2d6b129e-f848-4a39-9c34-d39846a2b7de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145673","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:d6177db3-11ef-446d-b83b-6a6257b0b2d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:55","original_object":"UniProtKB:P08908"}
{"id":"88e0128a-d765-4d03-b966-2c9ac6246eec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8346","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:9ae92c64-14eb-443a-b230-a6a049b935b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8346","original_object":"UniProtKB:Q8WXD0"}
{"id":"fa8982e1-5a0f-4818-a05b-eacb47c4e7b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6184","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:25e296c2-2742-4360-8927-3b3007636df1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6184","original_object":"UniProtKB:P52500"}
{"id":"1301fb29-c18a-40ed-b779-9ca414be1f9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11629817","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:77b09741-6abc-45a9-a6c1-159c5c8c6325","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4099","original_object":"UniProtKB:P28476"}
{"id":"3bb3f27b-407b-42cf-90ba-b2d432a84642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125467","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:0d1fa73a-6399-4168-82ac-a8fd2bd81c22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1265","original_object":"UniProtKB:P58406"}
{"id":"8e9d3a02-2492-4da7-bca8-fce9eee93206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90677","predicate":"biolink:affects","object":"UniProtKB:Q9NQU5","sources":[{"id":"urn:uuid:4d22a847-df64-4d66-be4e-537e8946ac1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5196","original_object":"UniProtKB:Q9NQU5"}
{"id":"a67eacb9-b786-407e-b801-8ae56b88dc86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95073","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:298ff64a-0112-496c-9aef-4c8aa46ee17a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7010","original_object":"UniProtKB:Q9UBN7"}
{"id":"60fe830b-4dba-4af2-835c-23c21577aed7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47943","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:29d849ac-53c5-40d7-a3ff-1c34c6eb32b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4133","original_object":"UniProtKB:P48058"}
{"id":"a51fcf52-8843-4387-ad7f-7fcc80fef8e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118704753","predicate":"biolink:affects","object":"NCBIGene:10733","sources":[{"id":"urn:uuid:7396b795-359c-4234-be09-bc53dde11782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13844","original_object":"UniProtKB:O00444"}
{"id":"9061d9b9-7381-418a-855c-1278a95431ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600925","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:8ca36aa6-a346-45a4-999a-2392f806f3ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10541","original_object":"UniProtKB:Q9Y2T6"}
{"id":"2e34e7ce-075f-4b0c-bbf7-1917848ff463","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:667146","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:9b9e0674-eae8-48bd-a4d7-1032555781a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10290","original_object":"UniProtKB:Q9UL62"}
{"id":"efe5e586-2042-4d45-bf27-c276c5283790","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813886","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:e43543d8-b8df-4aff-859e-27b7535df6d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1535","original_object":"UniProtKB:Q9ERC0"}
{"id":"ac63a300-95cf-4fbd-986f-4dddb0cf36bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146170996","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:24542f75-3c44-40b2-88e8-4dfb34bdc570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10947","original_object":"UniProtKB:Q5S007"}
{"id":"fca9af3e-f0c3-49a2-821c-c6d31fa09c14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16130961","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:1166a6c8-a405-4201-945a-61d01653f1dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2005","original_object":"UniProtKB:P31391"}
{"id":"767eb5c3-6a20-45dc-ad07-b0b55f979ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7851","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:267041de-ecb2-4ee1-8461-e31ac0c6208f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:302","original_object":"UniProtKB:P08173"}
{"id":"00c52721-2305-424b-bf33-ffa09e2d5f17","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PV6YEC8983","predicate":"biolink:affects","object":"NCBIGene:2890","sources":[{"id":"urn:uuid:a8628a67-58eb-49b1-9623-82983e3d15de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4166","original_object":"UniProtKB:P42261"}
{"id":"11d755e7-9b8c-4e50-a5fe-1c83f0da6e4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13502","predicate":"biolink:affects","object":"NCBIGene:3654","sources":[{"id":"urn:uuid:f564d0fb-857a-4bb3-93c8-3b43ee779adc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13502","original_object":"UniProtKB:P51617"}
{"id":"a7c0118c-8f2a-4c1a-a170-09975199b1a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:862","predicate":"biolink:affects","object":"NCBIGene:12426","sources":[{"id":"urn:uuid:a4078454-6b93-4964-bde1-aae4b65dfe9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:862","original_object":"UniProtKB:P56481"}
{"id":"ee9df5fd-a9e8-4701-ac6a-afa58af57f7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47780","predicate":"biolink:affects","object":"NCBIGene:16522","sources":[{"id":"urn:uuid:154401ee-b548-4226-93b5-3a0ed1848acc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2398","original_object":"UniProtKB:P48542"}
{"id":"aca2b97d-1cca-40f9-ba0d-6662decae00b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:181441","predicate":"biolink:affects","object":"NCBIGene:259285","sources":[{"id":"urn:uuid:3c866ffc-24d2-461c-bf55-238c2fc97c09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12441","original_object":"UniProtKB:P59534"}
{"id":"3368b8ec-ae8b-419c-a63f-a2315001638a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GA36S2O9C2","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:65ba2a68-cccf-400a-8219-88eea38a1fae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4245","original_object":"UniProtKB:P42263"}
{"id":"7a10c498-aa0a-42b6-b746-be29835b1a7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134301","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:51c7189d-12af-40e6-a5a1-74e0806ee186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13515","original_object":"UniProtKB:Q92508"}
{"id":"68abe2a4-2d27-4547-8e24-3c878095a6f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:c0bbd0bb-35d2-47b3-83e3-0b4dcbc0686e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:O08726"}
{"id":"f0ab397a-0adb-4c5b-95e9-619fb89079d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2013","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:b8648d33-60f9-4012-b906-4e8e5fb6c17b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2013","original_object":"UniProtKB:P32745"}
{"id":"74b6cb8d-d6a0-40e4-8af4-385e645c315e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OE1QTY7C25","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:d3f2c2fd-6046-4b6b-b6ae-cef932ff50c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10631","original_object":"UniProtKB:P52333"}
{"id":"a9e31f55-49e6-4de6-90db-5b1b608cae89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C6RWP0N0L2","predicate":"biolink:affects","object":"NCBIGene:1459","sources":[{"id":"urn:uuid:96b4ec9d-fcc4-413c-ad88-aff377c0ca12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8126","original_object":"UniProtKB:P19784"}
{"id":"e5bfefb2-9810-4d87-b7ff-c4170defd4e2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL1289316","predicate":"biolink:affects","object":"NCBIGene:12772","sources":[{"id":"urn:uuid:d5195cad-2126-4e65-9f8c-8434feb562c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:777","original_object":"UniProtKB:P51683"}
{"id":"f3f62015-27d8-4829-9788-9b8d100b93f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1181","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:2a028ed2-012c-46d0-bcfd-7a2e97755157","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1181","original_object":"UniProtKB:P30968"}
{"id":"c428e9bf-020b-4cf5-998d-fbf912dc22c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:ee7049be-0b08-4189-a7d7-7134dfab180c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P08581"}
{"id":"33ff5744-f34a-40a3-b75c-ef0a6d9859d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2825","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:dd28a5c8-9dbd-46b9-a74a-f2e241a9e722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12438","original_object":"UniProtKB:Q9NYV8"}
{"id":"a52b0449-d4c9-4d84-8770-057552073c21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2007","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:cdbb57ce-ed45-4196-9b07-54c3bc814895","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2007","original_object":"UniProtKB:P35346"}
{"id":"9f7b3c8b-a1c3-4a1c-988d-060aa8002e4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73364","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:63218941-b3f3-422c-8e23-880087f91a40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7","original_object":"UniProtKB:P32304"}
{"id":"447b5b46-9ae9-4cc0-a046-12500481fc4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:18397","predicate":"biolink:affects","object":"NCBIGene:134864","sources":[{"id":"urn:uuid:9e89a973-891a-4a6e-b1a6-315eb3225c06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2144","original_object":"UniProtKB:Q96RJ0"}
{"id":"bf55ddab-ebd8-4451-b8cc-ce74798a754d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16731","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:30b76d62-813f-4762-9787-9d3832f28cab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2423","original_object":"UniProtKB:Q8K424"}
{"id":"8d56f503-7198-4a90-810e-d43fb2ed2b99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10041551","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:60dbdf89-da3c-4ecb-9b19-82792d2ab374","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7537","original_object":"UniProtKB:P23975"}
{"id":"eae8c24b-c281-453a-8851-9f8f7ae64040","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PY79D6C8RX","predicate":"biolink:affects","object":"NCBIGene:1080","sources":[{"id":"urn:uuid:556cb73f-7036-4657-a6d8-a18f85cf21a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7453","original_object":"UniProtKB:P13569"}
{"id":"1a150bec-694c-4c6e-b3d7-8db6df146cad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134457640","predicate":"biolink:affects","object":"NCBIGene:166614","sources":[{"id":"urn:uuid:63cab43d-81a8-48a1-86f9-73430372c523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11114","original_object":"UniProtKB:Q8N568"}
{"id":"12828946-0299-4bb2-97d4-17bf4e1f52fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44444843","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:727aa8e7-7e49-47f8-86e2-0d5538aca306","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8122","original_object":"UniProtKB:P17948"}
{"id":"64f2fc04-4359-4d42-a6e4-c7d670a3ace7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:b14b8959-23a7-4b60-b6f8-8edbc1a7a432","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P35462"}
{"id":"8ce11b15-8b7e-47f4-960e-574d911dcf23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZET7B198W2","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:5d875625-102c-4829-9ba0-221791ec6ff9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:525","original_object":"UniProtKB:P18825"}
{"id":"1e6f21ba-80fd-4526-a73b-6033b343e6de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28969","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:2a82a363-4489-40f9-bcf3-cd297d705803","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:141","original_object":"UniProtKB:P28221"}
{"id":"338f1bf8-44cd-403d-b450-719f31850cbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:b13b8da2-fbeb-4667-85c2-ec0022c63f7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P41595"}
{"id":"46f1be0b-1839-4728-9b24-91f93cef0d4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1479","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:85981900-16d8-455f-b57a-9c859a9012a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1479","original_object":"UniProtKB:Q9GZQ6"}
{"id":"7164e4fc-70d4-4d6a-9f67-063bf1c8aa91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:219770","sources":[{"id":"urn:uuid:a5d28773-529d-4e2a-9085-312887614360","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q96KN9"}
{"id":"b4c360ec-eacd-4c87-90aa-a81e91aab68e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6I7PLF6N8L","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:10ce13b6-ad67-4764-a800-61e2beb9c395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9905","original_object":"UniProtKB:P16234"}
{"id":"ab5311cf-c9ed-4bfd-9d23-cfbc104554d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947075","predicate":"biolink:affects","object":"NCBIGene:29733","sources":[{"id":"urn:uuid:dd4ccf7c-8acb-47ec-bac8-605de6a6e9e8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2923","original_object":"UniProtKB:P48303"}
{"id":"3ff708ed-0068-44a8-a097-590b51b51aa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11526708","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:eff23c28-0b66-462a-950b-d5bd80ce5e63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8812","original_object":"UniProtKB:O14684"}
{"id":"7c609495-c215-402e-af3a-66dd511dacea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KZ1O2SH88Z","predicate":"biolink:affects","object":"NCBIGene:91039","sources":[{"id":"urn:uuid:fa520515-ebdf-4e66-8cab-ce2e92fe948f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9892","original_object":"UniProtKB:Q86TI2"}
{"id":"3c055752-87c6-4ebf-92be-7e090b0b3eb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827382","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:b47c60f4-5758-4ced-a2a6-f6baf770e143","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8639","original_object":"UniProtKB:P11362"}
{"id":"a07a44f4-4826-46e7-9a89-050a62254693","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:5672d7e5-8897-4a26-92df-e1b96039545d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P21728"}
{"id":"92ba0615-12d5-44e6-a792-cefd4ed17373","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2549","predicate":"biolink:affects","object":"NCBIGene:29731","sources":[{"id":"urn:uuid:82114fbc-62d6-4daa-a65e-319f6585dd6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2549","original_object":"UniProtKB:P15384"}
{"id":"df4c48c8-adff-4200-9ee9-ce9eb72417c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135348858","predicate":"biolink:affects","object":"NCBIGene:3065","sources":[{"id":"urn:uuid:955e682e-466d-4555-bb1c-7e5c2978c98a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10490","original_object":"UniProtKB:Q13547"}
{"id":"d47b444e-0931-46b4-9f37-0bae0cabb4da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J6U9WP10T7","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:fca04789-9cea-4ea4-b0e3-0c1e9cd0b43c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7885","original_object":"UniProtKB:O14965"}
{"id":"9ea2fbce-e3ff-4835-888b-d9e45fc1eca8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91370","predicate":"biolink:affects","object":"NCBIGene:2185","sources":[{"id":"urn:uuid:0c5766b6-74b5-4cf5-bf45-102229289b9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9381","original_object":"UniProtKB:Q14289"}
{"id":"4049f9f0-0f28-4708-a6ae-c8c505ededde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2043","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:7a39a1df-42c2-411d-9369-0d524180d1bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2043","original_object":"UniProtKB:P30875"}
{"id":"fddb57d2-77f1-41e0-9c65-9510eddf22ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32168","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:d790d4b4-6ec7-4d70-b311-2a516a198384","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5501","original_object":"UniProtKB:P14416"}
{"id":"b1fd8c15-8b4e-440d-81f3-61f3a5735966","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134724","predicate":"biolink:affects","object":"NCBIGene:20537","sources":[{"id":"urn:uuid:826d922a-6583-49fa-abf1-4dad779f4c68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9394","original_object":"UniProtKB:Q8C3K6"}
{"id":"ebb9b66d-1534-42e5-94bc-933ddf1d9d76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817440","predicate":"biolink:affects","object":"NCBIGene:65180","sources":[{"id":"urn:uuid:383cbb61-c49b-4b02-9534-29a1f52d1570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2584","original_object":"UniProtKB:Q63881"}
{"id":"60dbfd61-8798-45ae-a5b8-19d90bd4bc6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122379290","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:f2ae8f2a-b4d2-4cb3-b86e-37b92574aaba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9660","original_object":"UniProtKB:P51449"}
{"id":"c279ffe2-1b25-417d-b24d-beb4529eafe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:164890","predicate":"biolink:affects","object":"NCBIGene:50832","sources":[{"id":"urn:uuid:acfc3f70-94c1-4e5e-a9d1-84cc6f3a615d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12424","original_object":"UniProtKB:Q9NYW5"}
{"id":"6952a1d0-a33e-4c9f-934b-f70d3c4c8ee2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12564","predicate":"biolink:affects","object":"NCBIGene:41","sources":[{"id":"urn:uuid:e376814b-a37f-40cd-9d6e-3e6af8eef130","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12564","original_object":"UniProtKB:P78348"}
{"id":"9c861d5e-32a3-45a6-9fc4-12f0d9f7329f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:80bb978a-351f-428d-acc9-2425344c59f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3976","original_object":"UniProtKB:P43681"}
{"id":"215d69fd-be45-4c7b-93b1-f4457976cf8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11617054","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f50bd8ca-4e32-4edf-aed2-ae7da597cbbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9813","original_object":"UniProtKB:P30542"}
{"id":"8bb0651a-1220-44a7-994e-73c759acb66d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9865554","predicate":"biolink:affects","object":"NCBIGene:3579","sources":[{"id":"urn:uuid:9b875a6e-8089-40af-8177-9ee37a264039","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8497","original_object":"UniProtKB:P25025"}
{"id":"d553311c-31b7-4d7b-9ecc-b01004c3fbc3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:343450","sources":[{"id":"urn:uuid:682da31c-aa53-41c4-a03c-7b9e2836a62d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q6UVM3"}
{"id":"5ffe3f10-6741-4a6f-b257-c10052091c05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3354","sources":[{"id":"urn:uuid:1c068204-3ff8-4113-83fc-a536197e838f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P28566"}
{"id":"df971c83-d15d-452b-bb56-f8a4816bd82b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:187612","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:b952ff80-9a3e-46d1-919c-62124d3de6a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2948","original_object":"UniProtKB:Q15722"}
{"id":"c8fb6b34-96b5-4cf9-b375-40e0f327ed2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JTZ51LIXN4","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:71eec379-4fe0-4607-a42e-692a05baa2e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11413","original_object":"UniProtKB:Q06187"}
{"id":"5a86ea57-d727-4064-9bdc-67c62fba11e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:59L7Y0530C","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:49a86bc5-6710-4c60-9aec-c79464294f8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11619","original_object":"UniProtKB:P35968"}
{"id":"2b014a6e-7a65-48bf-92da-7a8545793a03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287532","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:dc5fb8a2-fa48-43e2-a017-4a81bb125480","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11713","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"00952a83-3ae7-4394-b8c8-74295ef56531","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:4890162f-e690-4d3f-bf02-9d16765b871e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P35367"}
{"id":"89f818bd-d0c7-4ccf-8804-8eb127b22f4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64177","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:21b1160c-a3c5-48ea-9f3f-382839a17d0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1223","original_object":"UniProtKB:P35367"}
{"id":"33eccebf-5778-494d-8798-0445fb4d9cbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311001","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:a1437e5d-5d48-4c07-8e7b-4d019bc85838","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:341","original_object":"UniProtKB:P20309"}
{"id":"54731169-eac4-4045-8aed-2777876e8bae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91754554","predicate":"biolink:affects","object":"NCBIGene:94","sources":[{"id":"urn:uuid:47499c4f-1487-4acc-991a-7a99414878a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8481","original_object":"UniProtKB:P37023"}
{"id":"c984614f-f6f9-4472-bd6d-6ec1ec283ef7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8060","predicate":"biolink:affects","object":"NCBIGene:8639","sources":[{"id":"urn:uuid:cce13ae1-1392-487e-bd54-505614044e26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7266","original_object":"UniProtKB:Q16853"}
{"id":"37564a81-5c91-4de6-bd6b-6fdec743e13e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73386890","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:ab4f2baf-6f90-4e7b-ab80-acbc218bf3cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12706","original_object":"UniProtKB:P33981"}
{"id":"e761140c-5a69-4d3c-a447-9aacc5a1abb8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:16502","sources":[{"id":"urn:uuid:a73e8fd2-8e39-4c89-a76b-837b24748aba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2486","original_object":"UniProtKB:P15388"}
{"id":"6b74efac-8013-4aa2-a715-032b090620ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145900918","predicate":"biolink:affects","object":"NCBIGene:57787","sources":[{"id":"urn:uuid:e79bba58-8c7a-4f37-b501-53770e340126","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11896","original_object":"UniProtKB:Q96L34"}
{"id":"22f7befd-ac66-478a-9312-77cef7ffe752","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135632","predicate":"biolink:affects","object":"NCBIGene:5644","sources":[{"id":"urn:uuid:8879e244-fcb8-4165-acd7-65912944285e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6432","original_object":"UniProtKB:P07477"}
{"id":"cdf84f06-5594-42c1-a349-19836aa81063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5644","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:3eba26da-1dc4-4920-8b65-9a4f45c71087","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5644","original_object":"UniProtKB:P30874"}
{"id":"f13aa431-5009-46ab-8c71-061fded90fb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:184540","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:1767cef3-8412-452d-9c6b-92e0c1aa137b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2958","original_object":"UniProtKB:P04035"}
{"id":"579bfeb4-bf66-4957-b819-8d427f5f2af8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755198","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:cbbbc4d2-e100-4f59-ac0c-6b5b47087102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6236","original_object":"UniProtKB:Q14833"}
{"id":"31120397-038b-44fd-a913-bc109189d95b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:165437864","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:176d7c74-2be0-464e-aa21-89bddd31ba63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12262","original_object":"UniProtKB:P37288"}
{"id":"9796968f-01c4-4f05-b6df-6ee1b05c7ae6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QQS4J85K6Y","predicate":"biolink:affects","object":"NCBIGene:6335","sources":[{"id":"urn:uuid:91a64443-a2ea-4446-9828-92e009481c7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12645","original_object":"UniProtKB:Q15858"}
{"id":"14d8c317-6883-4115-8cef-68bc21d2e7f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5282428","predicate":"biolink:affects","object":"NCBIGene:5739","sources":[{"id":"urn:uuid:3bf03961-4ee5-4c62-a66c-ba1c7c0095e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1967","original_object":"UniProtKB:P43119"}
{"id":"40c92b14-dcb6-4fb3-b942-e468b68d75c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27732","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:d6ee10e9-ccc5-4e44-b5dd-17222fa3e5b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:407","original_object":"UniProtKB:P30543"}
{"id":"d5b86c3a-5995-4211-a687-b29d6209bfee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:553827","predicate":"biolink:affects","object":"NCBIGene:590","sources":[{"id":"urn:uuid:1c9a6e26-0794-4901-9690-e34bb08932da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6601","original_object":"UniProtKB:P06276"}
{"id":"5abafcfc-4b66-4abd-8dea-4c82ca031011","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155190269","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:e2c7aa17-be36-47a8-94a6-30317f540f48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12357","original_object":"UniProtKB:P10721"}
{"id":"f06611b9-4919-458e-acc8-dc958d6728f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:77461257","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:374ed5dd-a5de-4011-817b-11b6241113a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11316","original_object":"UniProtKB:Q9JL06"}
{"id":"974897f4-a1e4-4fb4-b34b-bcc5617179fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:b12da2db-fa36-4705-a2d9-c8eed5ea76a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P47900"}
{"id":"123833d5-0b5c-4a6a-8350-2aac3afbd2e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16356","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:73e7bfde-638a-44d7-a857-b9205fd09a13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2347","original_object":"UniProtKB:O88703"}
{"id":"a7785dee-0601-494e-bb29-4fd01750e2d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:a4948ea9-65c2-4797-8d1d-c902c1ead82f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P08172"}
{"id":"9e95eb63-c15d-422b-bf7b-54e94201402b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7035","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:8dac27ed-941e-4023-9ead-cf7f10e0413b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4090","original_object":"UniProtKB:P47869"}
{"id":"7514ca4b-c8b2-41eb-a841-7f52a03b3ba0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:2841","sources":[{"id":"urn:uuid:e9dc03ee-f48f-4571-abb8-8037f55ec0c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q14330"}
{"id":"60a93d78-120a-4968-a625-f138c7da7146","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28499","predicate":"biolink:affects","object":"NCBIGene:766","sources":[{"id":"urn:uuid:db0ddf00-ca01-47a6-8703-c909e0e5da08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11052","original_object":"UniProtKB:P43166"}
{"id":"f1aeb51f-8777-4b7b-a1ed-6427874f462d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59204","predicate":"biolink:affects","object":"NCBIGene:18430","sources":[{"id":"urn:uuid:a74a0318-ac82-47f8-8c65-1cadfe9547f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11169","original_object":"UniProtKB:P97926"}
{"id":"f2b3472b-ed94-4314-90c4-5bfd33dfb6c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70945511","predicate":"biolink:affects","object":"NCBIGene:13040","sources":[{"id":"urn:uuid:7598b170-950a-4058-b1cf-56b6824c73a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10746","original_object":"UniProtKB:O70370"}
{"id":"35abee3b-7636-4511-9ecf-c78b2753b2de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5120","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:539c8cf3-733e-4885-a54e-b107f52ee962","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2861","original_object":"UniProtKB:P10275"}
{"id":"1abf08cb-fd17-44c4-872e-829e2b14378a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:f22f9d2f-b373-43ae-b865-b4a1b56f5ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P30680"}
{"id":"e568e561-7d5a-47f6-a4ee-4d820cff819c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6437356","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:aef76d8c-5e9d-4c11-bb76-0b900f445a8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4170","original_object":"UniProtKB:O15399"}
{"id":"16575417-e404-4a92-a14e-f9e19c4ccc9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28918","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:6fbd1f71-67e0-4689-aa04-dd4aed44c61f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:479","original_object":"UniProtKB:P18825"}
{"id":"34689615-bab4-4b37-8684-9a5c55deda84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76072859","predicate":"biolink:affects","object":"NCBIGene:55351","sources":[{"id":"urn:uuid:6c0e16d4-04f6-4588-8f4d-36f6c311cef9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8219","original_object":"UniProtKB:Q9NY57"}
{"id":"2309a001-1b32-464f-a85a-8df12b620583","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46871638","predicate":"biolink:affects","object":"NCBIGene:55589","sources":[{"id":"urn:uuid:c98d96f8-dcce-4651-bc65-0dd139631585","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8206","original_object":"UniProtKB:Q9NSY1"}
{"id":"4703b08c-5028-43fe-b6a5-cb9e865b2446","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:928","predicate":"biolink:affects","object":"NCBIGene:64680","sources":[{"id":"urn:uuid:01577099-4052-4ca9-966d-5c8df9589fb9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:928","original_object":"UniProtKB:P47866"}
{"id":"622e5a17-fdbf-4bd4-bbdd-6c8766538fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C0Z095LL72","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:723373fa-6ebb-468b-9447-16d74fb8b1e6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11934","original_object":"UniProtKB:P22607"}
{"id":"53449536-83c2-40fb-ac58-08503ac56364","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59397065","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:175b23db-1683-4868-bf39-9ef1052ed7da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8071","original_object":"UniProtKB:P04629"}
{"id":"b2fea25d-c801-4d58-808d-0e5039edcc44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L1V1K2M4V","predicate":"biolink:affects","object":"NCBIGene:230777","sources":[{"id":"urn:uuid:88c5dbfc-2d5a-4ab5-8b84-1999e8892a12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4461","original_object":"UniProtKB:P58307"}
{"id":"2bcc120e-48af-4468-8517-cf500e724404","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132084","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:9e9aa754-65cb-43f2-8277-633b054c158f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6043","original_object":"UniProtKB:P10721"}
{"id":"2a8cde3c-4973-4a6d-b8b1-af8463028a14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321937","predicate":"biolink:affects","object":"NCBIGene:25590","sources":[{"id":"urn:uuid:d8bac160-ca8f-4266-aa58-b176a4792523","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3979","original_object":"UniProtKB:P09483"}
{"id":"aaddae7a-5e5e-4c46-912c-65f11007c4f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24825779","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:c86cead3-118a-4339-bb28-de2275dc4a68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11407","original_object":"UniProtKB:P49841"}
{"id":"cc85bd77-d230-4299-9513-9ebf328f1bdd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122589101","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:064ee1e7-dca8-47de-b3cb-0962ba09a7a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12551","original_object":"UniProtKB:Q8NET8"}
{"id":"4fa1cef3-4b30-4b3b-9a95-3eba8d5e7c9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5840","predicate":"biolink:affects","object":"NCBIGene:14293","sources":[{"id":"urn:uuid:ae4451a8-6918-4234-802d-523c0bee8f36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5840","original_object":"UniProtKB:P33766"}
{"id":"d0caee17-d97d-449c-867a-5648ef6b2fe1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4636","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:b52bf279-ce45-43ab-b76d-ff99aabd7e86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1224","original_object":"UniProtKB:P35367"}
{"id":"e5fc3b7d-4287-405f-8949-12b39f9ec674","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440621","predicate":"biolink:affects","object":"NCBIGene:4160","sources":[{"id":"urn:uuid:1b1c9bb9-77ba-4c20-9dc1-fb141cf89621","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1325","original_object":"UniProtKB:P32245"}
{"id":"2a321b03-591b-4299-89e1-5715336db7bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28610","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:b8d8c319-64b2-48c5-b06e-ed064b580a58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3623","original_object":"UniProtKB:Q8TDV5"}
{"id":"76e7af04-8fc4-4fbc-aa71-9bf245223f1f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600927","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:f7cef1e4-169c-4837-8380-aa50c02450d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10543","original_object":"UniProtKB:Q9Y2T6"}
{"id":"08387806-023e-4ee1-92fa-9390d2dca1d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30772","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:b59a7670-6eb6-4e7b-90de-8fcb9ddd2a5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1059","original_object":"UniProtKB:O15379"}
{"id":"4ae69523-a482-4189-b3b6-a83bec3ebe6c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:102029","predicate":"biolink:affects","object":"NCBIGene:231","sources":[{"id":"urn:uuid:82110d4f-e44a-47a9-ba69-df63046d0dda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7415","original_object":"UniProtKB:P15121"}
{"id":"39393008-2cfd-4680-99c7-aea60b18ea65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188072","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:ac5c6345-39b1-4a34-9669-18c0d12719a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:67","original_object":"UniProtKB:P28223"}
{"id":"a579c7c8-25bd-46e6-99f1-043e788bbbdf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5OGS5K699E","predicate":"biolink:affects","object":"NCBIGene:10461","sources":[{"id":"urn:uuid:0f43de39-cbec-445f-ae4b-8a93362ffaf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9841","original_object":"UniProtKB:Q12866"}
{"id":"4ee0f9ce-e55a-4eca-9fb6-7849882c298e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9793868","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:f4deec8e-587d-49e0-a676-fc9374c55a23","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1252","original_object":"UniProtKB:Q9Y5N1"}
{"id":"8a9c5871-93e3-424d-829a-b5baea7b98a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8428","predicate":"biolink:affects","object":"NCBIGene:50835","sources":[{"id":"urn:uuid:46020e82-0885-4f19-a1db-510331054bc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4811","original_object":"UniProtKB:Q9NYW1"}
{"id":"b29135fe-4c99-4bba-8370-9c288cd319e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15854","predicate":"biolink:affects","object":"NCBIGene:222962","sources":[{"id":"urn:uuid:bdd94ee2-d76a-4eda-ab4c-7a24bff42c32","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2510","original_object":"UniProtKB:Q7RTT9"}
{"id":"c43e8879-19a4-4c40-90ce-56a5c0adda19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132220479","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:29296a90-3a97-477b-b43c-1915d383aac1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10001","original_object":"UniProtKB:O00329"}
{"id":"1ad67e7e-bc55-4a5e-9120-135bec8d921a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6082","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:7f4535f9-cb69-4c3b-92d9-fdf543e62cd4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6082","original_object":"UniProtKB:P47211"}
{"id":"32705156-bd41-4099-b3ab-ae7146e72bfa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:3762","sources":[{"id":"urn:uuid:6e6f340b-6b9c-48f0-962f-8b033101245b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:P48544"}
{"id":"86c101ee-efa5-4877-b616-56c9f2d4723a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15217432","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:f39cb05a-0d9b-45a1-8adb-914766d3a38f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2708","original_object":"UniProtKB:P37231"}
{"id":"57a51d3d-7668-4f3b-8db5-2fd409b7c489","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8B97A88D35","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:59a81237-02d7-4f8c-b91c-008c41776754","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8915","original_object":"UniProtKB:P42338"}
{"id":"7b5d4b52-2c45-4aaf-bbe3-8142d3d03fd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65408","predicate":"biolink:affects","object":"NCBIGene:50836","sources":[{"id":"urn:uuid:365c4689-b114-4523-9d4d-ed747816f5fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9675","original_object":"UniProtKB:Q9NYW2"}
{"id":"6c26de6a-c64b-49ec-8b90-389e7fb74232","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81569","predicate":"biolink:affects","object":"NCBIGene:2492","sources":[{"id":"urn:uuid:9c5ef9ff-dd21-4e5d-ab64-d0cf7b1fa366","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1157","original_object":"UniProtKB:P23945"}
{"id":"f77a4538-3839-47c0-af27-ecaa1cf5b9db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71656212","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:60ff7c5c-5dcd-4495-b6c1-f7888a2a71ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9482","original_object":"UniProtKB:Q99685"}
{"id":"f1a9cec5-482e-4a52-b057-3eda5aeeaae5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72317","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:6b3c0a66-215c-4277-b3ee-b9c029e832e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5887","original_object":"UniProtKB:P07949"}
{"id":"40814b99-065e-4f24-b7ef-cfbf69ae3faa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358908","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:9cf97307-ad69-4bb6-b8a5-2f74fa373106","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:344","original_object":"UniProtKB:P08172"}
{"id":"7c238989-da54-4d0a-b6a9-17d92a4c9f86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5284330","predicate":"biolink:affects","object":"NCBIGene:8323","sources":[{"id":"urn:uuid:c0d3dd71-93df-4f7f-9517-79accdf5e8dc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10327","original_object":"UniProtKB:O60353"}
{"id":"ccd7277a-3c51-48c2-9ff3-107fcf4432f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15746","predicate":"biolink:affects","object":"NCBIGene:68667","sources":[{"id":"urn:uuid:f2548504-56fd-4573-8fde-4c2e43bb06f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:710","original_object":"UniProtKB:Q7TN37"}
{"id":"4300653d-70cc-4198-bde3-bb885dc9dc59","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T23RPA8WA2","predicate":"biolink:affects","object":"NCBIGene:114548","sources":[{"id":"urn:uuid:16f4f6bc-e749-4d02-8858-60588ec9ce68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12173","original_object":"UniProtKB:Q96P20"}
{"id":"7e561ba1-00f2-4515-b366-42f6fea39ec9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:3744","sources":[{"id":"urn:uuid:2f9ae2f3-c50b-4fa9-a4c8-8480b370a0e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:90","original_object":"UniProtKB:Q16322"}
{"id":"6b885a61-88b9-417e-aabf-538ef774ce74","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:59204","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:6e3965ee-7604-4f1c-ad3d-d9d6606b34c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11169","original_object":"UniProtKB:P30559"}
{"id":"fd3703cb-3fd2-4623-80ff-5870cef71f21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10119","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:021aabd5-666b-4da1-81b0-55823a2e5ff6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:59","original_object":"UniProtKB:P35367"}
{"id":"10091eee-d1cd-48d5-927a-3c7863a57dcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NA1U919MRO","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:f4915155-fe27-47bd-bf2f-dfdaf11ae2bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9044","original_object":"UniProtKB:P41145"}
{"id":"a93ab205-3a90-428b-90e4-a6d305a7adea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:539503G9M0","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:ca130922-e458-4eee-b15d-a284cdf70ac0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1305","original_object":"UniProtKB:Q99705"}
{"id":"5a7f94e2-5487-41eb-b6cb-1ab204b67d2f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232162","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:67ecffb1-64b5-40df-afb0-07611ba05413","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5979","original_object":"UniProtKB:P49841"}
{"id":"1a14b5fc-1647-4fa2-86c7-7919af22c890","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280679","predicate":"biolink:affects","object":"NCBIGene:169355","sources":[{"id":"urn:uuid:e2f3e241-963c-4cc3-869e-8138beb52c08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12668","original_object":"UniProtKB:Q6ZQW0"}
{"id":"cb235aeb-78f5-4070-b928-efa91be39f4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40629","predicate":"biolink:affects","object":"NCBIGene:2066","sources":[{"id":"urn:uuid:71403697-2e77-425f-bd15-c47b6bf1f98c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7643","original_object":"UniProtKB:Q15303"}
{"id":"78803f79-0dec-4840-8dae-d7d4858d95af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:V4434XWK2P","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:5bffaaa2-8d0d-49f7-af90-fb284ca89d7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3319","original_object":"UniProtKB:Q8TDV5"}
{"id":"4ecfb02d-0b91-4b26-a47b-e27d7a32c9a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755209","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:4243c84d-bdd8-467e-879f-ded215b29897","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6343","original_object":"UniProtKB:Q13255"}
{"id":"69dfc9f3-20f8-480e-aa55-422c02232f90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:1d571de2-5369-4ab2-959a-e73428f70677","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P28221"}
{"id":"c7e6fd08-d109-4492-ac7f-e4a975c6094c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6781","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:380cf2c0-25e4-458a-b0a4-1ada9150c78e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6781","original_object":"UniProtKB:P11836"}
{"id":"4ead5648-a268-4101-b1cc-2104c7c092f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:70ad2902-b444-4627-b9aa-74612178dbbf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P43116"}
{"id":"ad86037d-816d-442c-a62d-cdac7ff97eed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73224","predicate":"biolink:affects","object":"NCBIGene:312896","sources":[{"id":"urn:uuid:5c4a417e-f437-47ef-8fe8-a8bafec50536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2420","original_object":"UniProtKB:Q6RI86"}
{"id":"d5694f85-fcd0-4edb-ad63-d1e067f8f774","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6912","predicate":"biolink:affects","object":"NCBIGene:7054","sources":[{"id":"urn:uuid:33acbcf3-8d02-448f-9e55-31299d903b92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6956","original_object":"UniProtKB:P07101"}
{"id":"10ad7b35-cb3f-476b-8188-19274862e747","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71306","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:468fd8a7-9880-4dc4-b3f6-caef232f6aab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2054","original_object":"UniProtKB:P30875"}
{"id":"312ff274-d503-4073-9637-ae6e212abbb2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145372","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:bc2155b5-3eff-4c5f-8f54-1b746da0e691","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8708","original_object":"UniProtKB:Q9UM73"}
{"id":"4af90c32-5ec8-4c61-a7de-565a63c593b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9893095","predicate":"biolink:affects","object":"NCBIGene:25014","sources":[{"id":"urn:uuid:b815dc2d-73e3-4dd6-b2c9-c2ef64e4a00b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6723","original_object":"UniProtKB:P17764"}
{"id":"2e788b36-8ebf-4d71-950d-f3e8a5e3a278","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58539171","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:1296f67a-ac64-4354-a7d5-b171da3ee3a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8073","original_object":"UniProtKB:Q5S007"}
{"id":"81e91539-1d80-4792-878c-8a606114826c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XQJ55R5PPQ","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:8c162f25-b39d-4e12-bf19-5c4df25fdf53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10361","original_object":"UniProtKB:P07949"}
{"id":"dbd2aa7a-97fd-44ae-8582-78f3cf53376e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66553218","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:f1861268-4199-479a-8169-b24eca112e63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7538","original_object":"UniProtKB:Q99572"}
{"id":"3d935f75-4f9c-47f4-aff0-7ced9e869465","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188612","predicate":"biolink:affects","object":"NCBIGene:9759","sources":[{"id":"urn:uuid:fa4e5abc-8674-4c46-93a1-407e1f7d05b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7916","original_object":"UniProtKB:P56524"}
{"id":"d6a70237-2645-4cbd-a8a1-cf4a39557d3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135954","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:162db04f-2375-4d0a-a315-d8dc4d504ca9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11579","original_object":"UniProtKB:P35367"}
{"id":"cd9ecbd4-d704-48b6-9a72-969666fc1e14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2654","predicate":"biolink:affects","object":"NCBIGene:1588","sources":[{"id":"urn:uuid:b5dd825b-de74-425a-b5a6-c0203985cf2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7054","original_object":"UniProtKB:P11511"}
{"id":"54c0ded0-9940-4aca-9f8f-08dfcb46d11a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50215","predicate":"biolink:affects","object":"NCBIGene:246788","sources":[{"id":"urn:uuid:2a2409bb-5844-47b6-9e59-e12207d56a9d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6415","original_object":"UniProtKB:Q8K424"}
{"id":"c99886a7-1841-4300-aa1a-5ebafd7942a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5RY1XQ9DDH","predicate":"biolink:affects","object":"NCBIGene:5663","sources":[{"id":"urn:uuid:0119f834-2cd2-4533-abfb-84dc8ee1265b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8848","original_object":"UniProtKB:P49768"}
{"id":"b08bfbad-b962-4111-80f0-9d098200b04a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3757","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:497b778e-7f16-4d69-9e92-1a30d6d99669","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:516","original_object":"UniProtKB:P08913"}
{"id":"ede9d748-a6cb-46a7-a674-766a2cb3ab85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:2d511e21-ee8a-4d95-9183-948850ce32b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P28334"}
{"id":"9820bc2f-dcfe-4e3e-b9a9-38397cb9bf4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77742","predicate":"biolink:affects","object":"NCBIGene:291","sources":[{"id":"urn:uuid:f09da404-fdeb-4c86-95ad-86c5225b44df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4689","original_object":"UniProtKB:P12235"}
{"id":"3d9aa754-b754-4714-9092-505830b84ef5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6923","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:e9b288d9-9616-4500-86eb-be1ee48501e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2449","original_object":"UniProtKB:O94759"}
{"id":"c77956ad-9be2-480a-bf68-6c9cf9823bda","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817427","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:e9e988f6-ff42-4264-9181-cc3b4f0d9b8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1788","original_object":"UniProtKB:P49190"}
{"id":"794fa67a-b76c-4bea-af67-43573d04a105","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46866192","predicate":"biolink:affects","object":"NCBIGene:2911","sources":[{"id":"urn:uuid:fb5985bf-c790-4915-b757-57990bc2b588","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6210","original_object":"UniProtKB:Q13255"}
{"id":"3d3665b4-7421-40f9-82d0-17fd086acd38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3919","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:bb0a6263-91d1-4504-ab6c-c86fd14c1b36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3919","original_object":"UniProtKB:P61073"}
{"id":"af1a5d40-635b-4c78-950a-c970f59fc4c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:174627","predicate":"biolink:affects","object":"NCBIGene:8850","sources":[{"id":"urn:uuid:e6e2b9b7-b3a4-411d-aec0-8066fd1307e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6999","original_object":"UniProtKB:Q92831"}
{"id":"378ab7e2-be2e-4bb0-bdd3-b0a27059cb45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232878","predicate":"biolink:affects","object":"NCBIGene:7225","sources":[{"id":"urn:uuid:77ffc078-ddba-45f8-9c15-fff1f51ae7e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10278","original_object":"UniProtKB:Q9Y210"}
{"id":"55a87021-c050-4fb1-ae35-f67cff4c66c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1697","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:c5dd7cb1-9056-4a58-ad2a-a6b350cc3aa2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1697","original_object":"UniProtKB:O43613"}
{"id":"5139e2a9-ccea-4da8-aac1-ad86e260b059","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11158623","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:bc195555-f4a9-4c81-8bc6-610927102320","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6226","original_object":"UniProtKB:P31422"}
{"id":"84f7339f-4863-4c19-9d34-65480137a583","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44629556","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:7b1f20bd-e8a4-4267-99d8-af94ff222a1d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3008","original_object":"UniProtKB:P51639"}
{"id":"6fa9e677-29f0-46f8-a2ac-cfbc1a0ad0fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E3DSH8LL4L","predicate":"biolink:affects","object":"NCBIGene:25797","sources":[{"id":"urn:uuid:7eed720b-9ee4-482e-b635-d3bd8414fc9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13397","original_object":"UniProtKB:Q16769"}
{"id":"4ebf33be-89b1-4ab6-82c1-b33f166ea745","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5854","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:93389c6f-3f8e-4344-a315-8fc4b7cdec68","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1371","original_object":"UniProtKB:P31424"}
{"id":"eab1d706-97bd-4944-b6ff-96668f5a6d8b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3935","predicate":"biolink:affects","object":"NCBIGene:2359","sources":[{"id":"urn:uuid:58acc239-96e4-49e0-8515-dff4f88fe7fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3935","original_object":"UniProtKB:P25089"}
{"id":"bb5aa76a-91b8-4125-8739-1576d04039f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O812716S9E","predicate":"biolink:affects","object":"NCBIGene:230777","sources":[{"id":"urn:uuid:8cd84abe-fac1-43c7-8fbd-5d82e343b301","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9306","original_object":"UniProtKB:P58307"}
{"id":"96ddedb4-177d-4c78-bf69-b2f0eb975c01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321930","predicate":"biolink:affects","object":"NCBIGene:6539","sources":[{"id":"urn:uuid:43482941-feef-4492-9209-aad55065d4ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6512","original_object":"UniProtKB:P48065"}
{"id":"49541b6e-e692-4b16-a3c5-0a7cdf03f600","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28487","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:3cedc84f-9023-42ba-93bf-335efa5ce37d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4823","original_object":"UniProtKB:Q05940"}
{"id":"57009518-e522-47f8-8515-9b18dbae1d52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6540277","predicate":"biolink:affects","object":"NCBIGene:27306","sources":[{"id":"urn:uuid:bcfac58f-d158-42e3-8220-fc5f1f5f2752","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6662","original_object":"UniProtKB:O60760"}
{"id":"cd2c38e3-dfa2-4131-bbe3-3aded5f58a56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13880","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:a006885f-668c-4c3b-b02a-4c8371232e88","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13880","original_object":"UniProtKB:P04626"}
{"id":"8953984c-34a1-48f2-bd64-36fd51018f95","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:7f5c0fb2-bca4-4ccf-91d7-e6d3252b88b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q9UL62"}
{"id":"869eea26-7af9-4d7d-a40c-ef099c6330bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:103854","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:3b1d3da1-d36c-46a4-8c16-cc756970fe3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:480","original_object":"UniProtKB:P35348"}
{"id":"672bbc61-9958-4241-8362-415e1daed469","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1483","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:49a48864-f546-4309-ac41-559268b742f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1483","original_object":"UniProtKB:Q9GZQ6"}
{"id":"3a31dbb0-beef-44f0-bfe9-a4ab80470d22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3V7GQ1260K","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:114ef521-62c1-4ac6-b0f8-aaec2a01dfe0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9697","original_object":"UniProtKB:O60674"}
{"id":"64f9ed09-30e4-46a4-8528-ddf2743110f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135530","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:378c8652-7a13-44c1-beb8-25d4c8e59332","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7483","original_object":"UniProtKB:P20309"}
{"id":"d1c3819d-37c5-4e22-98d7-5dbb225f1281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817460","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:f1a6c41e-eea8-494b-a77d-4d7dc16075de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3827","original_object":"UniProtKB:Q99705"}
{"id":"731ad4f2-67bb-4cb7-be32-56ce3b2cca5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145536","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:080c68f4-ef78-4f41-a939-fb0da019bd8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10679","original_object":"UniProtKB:P61073"}
{"id":"e5a936e3-05dc-4d82-9b23-eb68af12779a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3131","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:ba036a01-f0e7-402a-bdb1-0dbdb58a2207","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2338","original_object":"UniProtKB:Q9Z258"}
{"id":"dcc23cd1-0335-4bae-b01d-c8d16d0d5bbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45863","predicate":"biolink:affects","object":"NCBIGene:21898","sources":[{"id":"urn:uuid:5f621699-a3cd-47aa-b1e3-1fb1d0a1a97c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2770","original_object":"UniProtKB:Q9QUK6"}
{"id":"ddd8aa36-e936-4b9d-98b8-64bc7de26628","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93291","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:0ece19ae-2c91-407d-b618-6233dee97d0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11691","original_object":"UniProtKB:P35372"}
{"id":"41131b9d-a1ee-4021-94a3-477b2a407c43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10430549","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:cdf873dc-0ff2-4ee5-ba53-7604feb2bbe8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2929","original_object":"UniProtKB:Q9H228"}
{"id":"b2cc69fb-4fbf-4181-a3fe-9c2b775178c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10432715","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:5197d94b-3956-484c-b2b0-3861f540b51c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:460","original_object":"UniProtKB:P0DMS8"}
{"id":"dfdd380e-8b71-42b0-8029-6b3b05836719","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:663","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:37f2dea0-20a4-41e8-874a-7efb7d229bb8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:663","original_object":"UniProtKB:P97583"}
{"id":"cadb69af-a03b-4b6f-9c65-877531e4393f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2575","predicate":"biolink:affects","object":"NCBIGene:16500","sources":[{"id":"urn:uuid:dd5b541a-ae29-4348-89c5-68fa41f262be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2575","original_object":"UniProtKB:Q03717"}
{"id":"1a6cede4-7027-4d69-9bab-72922d7c95d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135761798","predicate":"biolink:affects","object":"NCBIGene:80122","sources":[{"id":"urn:uuid:23b39aba-08fe-4398-b669-789563270613","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8218","original_object":"UniProtKB:Q56UN5"}
{"id":"78cb6503-dcb6-4204-ac62-e133cbe852cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A6U64OU57E","predicate":"biolink:affects","object":"NCBIGene:6850","sources":[{"id":"urn:uuid:b4b8259a-9858-4836-bafc-93a37d3f7632","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9764","original_object":"UniProtKB:P43405"}
{"id":"48581d06-26f7-4f97-b85f-e3eef5ea075c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129257213","predicate":"biolink:affects","object":"NCBIGene:114862","sources":[{"id":"urn:uuid:5308b4f7-e409-4633-8ff8-fcab3c667fae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:10537","original_object":"UniProtKB:Q9EQ60"}
{"id":"84d82d59-12a9-4a6a-bb0b-57112932c26a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56833309","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:60bd652f-6ea4-4545-aafb-65257a793529","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9177","original_object":"UniProtKB:O60674"}
{"id":"ee41e122-5bea-469c-997a-e6f524f72b32","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87820","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:65efbfdc-3873-423a-80c1-9ddffe8e5215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1912","original_object":"UniProtKB:P34995"}
{"id":"148810f3-63e2-4166-a8cd-7bc375411b52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:60444","sources":[{"id":"urn:uuid:31254e33-8887-4884-bd77-8cf9757aac1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9Z258"}
{"id":"7881d29b-ae79-49f4-af3f-d0a4bcd16cba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GN465U8B72","predicate":"biolink:affects","object":"NCBIGene:133396","sources":[{"id":"urn:uuid:9a14cda5-d0bf-4ede-9776-ef59c5103263","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8720","original_object":"UniProtKB:Q8NI17"}
{"id":"c8071349-1616-4889-a967-c9120d4dfd20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:a66b2983-8a85-41c6-8144-808ef1e9170c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1638","original_object":"UniProtKB:P41143"}
{"id":"4b71782f-ff7e-42fc-a6b8-34ea12125dd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:872c0f8c-e19d-4d1f-abb0-a2400ffff408","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P31645"}
{"id":"d89ed473-342b-47ed-84d4-b86de9948141","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2700","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:4cdcba52-0749-4732-a0f0-14e1f7c18983","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2364","original_object":"UniProtKB:Q7Z2W7"}
{"id":"cd0a0e22-4087-4d16-8375-704ea5397da4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73288","predicate":"biolink:affects","object":"NCBIGene:25645","sources":[{"id":"urn:uuid:ad0ad7fe-bb11-4a29-be44-1fbf8d183605","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:532","original_object":"UniProtKB:P26255"}
{"id":"92c31f47-cad6-4c1f-a44a-252b72110f33","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ER33G946JT","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:794781b5-1e2b-4f8c-9979-cb0d20b3e5d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2249","original_object":"UniProtKB:P30559"}
{"id":"e9b5f3a9-871b-4eab-96cd-7462e4b9fae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1821","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:46e4ae3a-1a30-4c47-8e30-8690db551782","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1821","original_object":"UniProtKB:P49190"}
{"id":"bf937a5d-df8a-45f9-a8cd-0793deffcebd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94782","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:d15db231-9128-4d9f-8fba-158d08e8a989","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5664","original_object":"UniProtKB:P17948"}
{"id":"355f84ca-6016-49e7-8577-4aa6c119c322","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46195","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:e5efce58-e894-4819-ba29-85b517e12390","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5239","original_object":"UniProtKB:P23219"}
{"id":"c85c838b-326c-419d-a3b6-5052dca0e715","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6098","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:bfa9cfde-d5e2-4c9b-8030-1ad7ee859508","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6098","original_object":"UniProtKB:Q62805"}
{"id":"9e114754-4f74-46f0-acd2-a637cadc9356","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3213","predicate":"biolink:affects","object":"NCBIGene:6558","sources":[{"id":"urn:uuid:764e4048-ba3c-4370-9d25-b2a19c6b0016","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4837","original_object":"UniProtKB:P55011"}
{"id":"f69f3d1b-fc4d-4742-8a8a-a9eb9a3ce7bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2065","predicate":"biolink:affects","object":"UniProtKB:P30938","sources":[{"id":"urn:uuid:3eeba35c-de4e-4ee6-bd7c-da52ea9ac94b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2065","original_object":"UniProtKB:P30938"}
{"id":"75d03303-a49b-49d3-a2a9-80f60ae5ccc6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LMQ24G57E9","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:2d7f9b47-ce32-4598-9e53-3152fb9d9046","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11648","original_object":"UniProtKB:O43613"}
{"id":"579b5fab-b682-4cf0-b9fa-e62413c2a65b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135244","predicate":"biolink:affects","object":"NCBIGene:11556","sources":[{"id":"urn:uuid:6c3ddf01-fb4d-418b-aed4-e9738bb9739d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:571","original_object":"UniProtKB:P25962"}
{"id":"1b262f94-75bb-422b-b900-c9e81adab5e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8CZO0970G3","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:3b373d53-46cd-4e30-bfcf-106ed594dccd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4241","original_object":"UniProtKB:P47869"}
{"id":"55e03398-6c93-484e-9282-386bd069c07c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:b20a4b78-2f72-4cc1-8dea-f83ec15de07b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P14416"}
{"id":"33baef93-438c-4e86-9b82-464fe5e60719","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:37750349","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:fcc48dc1-f4ab-4d33-bfe9-c3837ae84ee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9655","original_object":"UniProtKB:Q9NWZ3"}
{"id":"24e40bf4-2b40-4765-80db-eb907e9ff285","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352896","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:17ac3f73-5ee9-42e3-a667-628caea91634","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3118","original_object":"UniProtKB:Q02769"}
{"id":"d3d8fafd-4bf2-461c-b531-0d88d256f601","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QJ8RO3296G","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:fc5b3642-6c0e-4704-8406-e91ca67ae0de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11879","original_object":"UniProtKB:P11802"}
{"id":"86d7f304-cba1-4370-a8f2-79f08336aeac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93424","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:ca5fbac4-deea-401c-8227-320b203938b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:403","original_object":"UniProtKB:P0DMS8"}
{"id":"7f8d2237-2cbf-4c15-9cea-16eaf601256c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72684073","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:427283ed-6000-40b9-a5b8-17c8208a2a75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7528","original_object":"UniProtKB:O60885"}
{"id":"7115f5ef-4eee-471f-8529-cee837e41db7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94409","predicate":"biolink:affects","object":"NCBIGene:55951","sources":[{"id":"urn:uuid:f343fa63-ea70-4bcc-8c97-e813783e0eff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11303","original_object":"UniProtKB:P63030"}
{"id":"0b3c09d9-8b80-4ae6-926b-d09f2484ac60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:2261","sources":[{"id":"urn:uuid:b6ad615b-de95-4019-a072-13ee2efb1820","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P22607"}
{"id":"b04779c1-550c-4dc1-b392-31bd2727d876","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6762","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:89c2cf54-4591-4331-8e9f-29ba0562357f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1227","original_object":"UniProtKB:P35367"}
{"id":"b79c221f-6290-4365-8d00-ad4dc56b5fe0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2258","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:7142814c-5e9b-43e1-b19b-c675a8f8e63a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2258","original_object":"UniProtKB:P41586"}
{"id":"330078de-7c1b-4b13-a58a-0928c257ece0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:167993665","predicate":"biolink:affects","object":"NCBIGene:83933","sources":[{"id":"urn:uuid:b5d6e85b-0eb3-44f1-bfd5-e5df331102c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12609","original_object":"UniProtKB:Q969S8"}
{"id":"eed6de26-40d7-47b3-b3c7-5316ee3dc1b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17489","predicate":"biolink:affects","object":"NCBIGene:15166","sources":[{"id":"urn:uuid:7dd92797-6c43-463c-9305-a86082f0fe26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2352","original_object":"UniProtKB:O88703"}
{"id":"a0d7af9b-134d-4265-98ff-a646eb5603d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9972691","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:a0c6ff42-4efd-4ede-a9dc-824ee8e5fff6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3418","original_object":"UniProtKB:P23385"}
{"id":"250eef3d-302c-4494-bf05-c24ad520dcd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134721","predicate":"biolink:affects","object":"NCBIGene:25702","sources":[{"id":"urn:uuid:4a3153bb-984b-418c-bda3-ea1f5fa50017","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11433","original_object":"UniProtKB:P27657"}
{"id":"374a3b8d-4f60-44de-92e7-61187f60defb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10231401","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:b05a03a4-dd63-48c3-b905-3d3f7f4c14ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5584","original_object":"UniProtKB:P30969"}
{"id":"e3688e4b-486b-478a-bc7a-70ed5ee7f59a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2631","predicate":"biolink:affects","object":"NCBIGene:25722","sources":[{"id":"urn:uuid:b0d4db4e-6af2-42aa-ab5a-fc97e8340a56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2631","original_object":"UniProtKB:P15390"}
{"id":"a146e32a-5cc6-4bb8-9f52-0b1d411506a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4UQ3S81B25","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:547792a7-b443-4b32-8141-4a43c7d4a44f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:225","original_object":"UniProtKB:Q13639"}
{"id":"4c3c0ba5-c9b4-47c2-8388-3083c99bf2e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10354477","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:ea299a71-9b9e-4f58-a6af-eb8b7b2864f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3345","original_object":"UniProtKB:P31424"}
{"id":"14988fb2-e32c-4ddc-9285-03b5dacb11be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34946","predicate":"biolink:affects","object":"NCBIGene:5032","sources":[{"id":"urn:uuid:fcc01302-7b3a-48cc-89fc-25ad661dbb13","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1739","original_object":"UniProtKB:Q96G91"}
{"id":"fdae40ac-4edd-43b4-a606-0bdae4517049","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7444","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:df4327a9-6ed5-4ce6-a5c3-6a14ebfbe44b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:554","original_object":"UniProtKB:P07550"}
{"id":"b41d2120-df01-4088-a404-be79780748ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:144948","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:a0257033-f7df-4607-a958-39b8e7161c25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3324","original_object":"UniProtKB:P21453"}
{"id":"eb34c4da-9e20-4b43-94ab-fd1f801621da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86268622","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:73d52bde-8296-48bb-95cd-b6f3b731fa7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10163","original_object":"UniProtKB:P42338"}
{"id":"d13e7770-c949-4e59-b834-5f29b9511c5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49864204","predicate":"biolink:affects","object":"NCBIGene:10524","sources":[{"id":"urn:uuid:6fabddb7-8b47-408c-8325-95cde7b88bb0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7488","original_object":"UniProtKB:Q92993"}
{"id":"85db6982-5bfc-49e6-be4b-a054f7d67738","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13887","predicate":"biolink:affects","object":"NCBIGene:961","sources":[{"id":"urn:uuid:987e56c2-9756-4dbf-9f8c-b4279f213f0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13887","original_object":"UniProtKB:Q08722"}
{"id":"5502992b-7c49-4c8d-afaa-549a43483c9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71509622","predicate":"biolink:affects","object":"NCBIGene:6543","sources":[{"id":"urn:uuid:b8ba6fec-70a6-41f8-9bb7-8a8b7d9bc0ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13934","original_object":"UniProtKB:Q9UPR5"}
{"id":"9ea17f44-e261-4de1-95a9-01b29a85ceca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:604","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:628321f5-ca1a-4bca-b48c-fd28f4d88a34","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:604","original_object":"UniProtKB:P35414"}
{"id":"2252458c-8195-434e-80fe-1d2ab10395fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2034","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:a359bf94-4023-4d79-b5ad-a80e8019ebe1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2034","original_object":"UniProtKB:P32745"}
{"id":"58bc2562-405e-40e0-9bc3-bef0f77d1f50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4944","predicate":"biolink:affects","object":"NCBIGene:2690","sources":[{"id":"urn:uuid:4dd7e9d6-9c01-445f-b8de-df33323189f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4944","original_object":"UniProtKB:P10912"}
{"id":"f625364e-6669-466a-83b1-7617978c257b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162679541","predicate":"biolink:affects","object":"NCBIGene:55283","sources":[{"id":"urn:uuid:5e28a538-0ffa-4ae5-9890-cfba5fc73789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11861","original_object":"UniProtKB:Q8TDD5"}
{"id":"d63caa6e-273b-4885-9f30-8f415fc8e108","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311001","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:0c436df5-1c70-4799-89b4-839dbc88c334","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:341","original_object":"UniProtKB:P11229"}
{"id":"9a9a344a-176a-47e9-bcc0-bc8053309a98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T4W68CAT3P","predicate":"biolink:affects","object":"NCBIGene:5159","sources":[{"id":"urn:uuid:71f3f0e4-a6e0-4eb2-8b73-87b443786645","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5690","original_object":"UniProtKB:P09619"}
{"id":"37fa0868-7caf-4a3c-bbb1-88add8ef738d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92540","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:ff5427aa-57e5-4867-b5c3-6ffafc7d1cf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5947","original_object":"UniProtKB:P49841"}
{"id":"a845771a-7444-47ea-9e41-e04eb3191dd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:45100481","predicate":"biolink:affects","object":"NCBIGene:11313","sources":[{"id":"urn:uuid:c2cc24d7-0e94-4705-a6b3-e2e18690a294","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13414","original_object":"UniProtKB:O95372"}
{"id":"e12b705e-468f-4074-a1ac-eba29ea7bf79","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63610","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:9d4e520d-97f7-46f7-9487-a7dfd0228f87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1936","original_object":"UniProtKB:P43116"}
{"id":"7e95a7b2-ebee-421f-bd51-67075d09fe0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W3IL23KVI4","predicate":"biolink:affects","object":"NCBIGene:1215","sources":[{"id":"urn:uuid:be369074-24ef-434d-9971-bf501ef1e97d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6563","original_object":"UniProtKB:P23946"}
{"id":"c56de8aa-c1cd-48cd-b13c-1f2adbed8900","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1455","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:a71584ab-8f8f-4888-85ac-c0b655660933","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1455","original_object":"UniProtKB:O43193"}
{"id":"bf892396-68a1-420c-be95-4faaccb5ba04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1109","predicate":"biolink:affects","object":"NCBIGene:25321","sources":[{"id":"urn:uuid:67f18853-c9da-425b-a560-0a0964177713","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1109","original_object":"UniProtKB:Q02644"}
{"id":"880be983-5356-4fe1-8d30-a449279feb7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73286","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:d72d4d0a-3210-49c1-88ce-0847661c7d37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:422","original_object":"UniProtKB:P29274"}
{"id":"439082b0-7356-448c-be2f-2a6d8cbf0337","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WBH8AY6ENB","predicate":"biolink:affects","object":"NCBIGene:1021","sources":[{"id":"urn:uuid:bd1af42d-3fd7-411c-b10a-026c856e249b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10313","original_object":"UniProtKB:Q00534"}
{"id":"c114faef-8f7b-4bd9-9891-565e7220d4ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61400","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:307ee287-1f3c-48b0-a4a8-aa5d77cf6ced","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9176","original_object":"UniProtKB:P00533"}
{"id":"a6cb383b-0011-4f42-81ab-271104d880d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8V9YR09EF3","predicate":"biolink:affects","object":"NCBIGene:84444","sources":[{"id":"urn:uuid:81342b93-4bb8-48e8-9928-e948a8c79006","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7019","original_object":"UniProtKB:Q8TEK3"}
{"id":"6b7e0a6f-12e1-44f0-a099-aaeb9347c206","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:165313","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:d8016eb9-13c6-42b0-94a5-54faeea82e92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1947","original_object":"UniProtKB:P43114"}
{"id":"0ffc3c29-3af8-4a32-ad9a-7c0901bc7dfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167664","predicate":"biolink:affects","object":"NCBIGene:5595","sources":[{"id":"urn:uuid:336ba8c2-8196-4e2a-a4b1-d38fae2e0c06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9974","original_object":"UniProtKB:P27361"}
{"id":"9bd43e93-340b-47d8-9cba-32490438ef58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817513","predicate":"biolink:affects","object":"NCBIGene:340061","sources":[{"id":"urn:uuid:257cec7c-af64-4805-ae8e-afe7c1789ea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11397","original_object":"UniProtKB:Q86WV6"}
{"id":"e66f7576-1f74-4038-b113-5872c8c84ed0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2126","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:33c936ad-83e0-43e0-b2d3-c86143137d8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2126","original_object":"UniProtKB:P29371"}
{"id":"a7bbbc94-951c-41ff-9e9e-10f03825a7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:1816","sources":[{"id":"urn:uuid:4f25098d-c2c8-4cf5-8bcb-07fe9111a767","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P21918"}
{"id":"6fc6c407-ddef-4cd0-bbf3-a050fb4ef2ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6SDJ3JV4WB","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c371a1c6-2c6e-49b4-9068-99a1c67e60a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3223","original_object":"UniProtKB:P28335"}
{"id":"6935a165-8af3-4c5b-85b4-adb7223f8a8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91091","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:0528a13c-05f6-4c64-bafc-0879a51e3cea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8014","original_object":"UniProtKB:P49841"}
{"id":"c39d321e-a8bf-401c-9070-0437a01d7599","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:37750349","predicate":"biolink:affects","object":"NCBIGene:6885","sources":[{"id":"urn:uuid:4827be2f-1630-4cd6-9246-fce12593d255","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9655","original_object":"UniProtKB:O43318"}
{"id":"d2eea4ed-94ed-4691-b9ba-c0d9c936c888","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232354","predicate":"biolink:affects","object":"NCBIGene:100359982","sources":[{"id":"urn:uuid:e0cbf119-b49e-4964-8277-b6e5f7034153","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11302","original_object":"UniProtKB:P38718"}
{"id":"5be04591-d5d0-4f87-b497-7977b6dbefcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34992","predicate":"biolink:affects","object":"NCBIGene:29627","sources":[{"id":"urn:uuid:5c9aadd7-e402-455a-92a3-f8c3d1f6f8dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8279","original_object":"UniProtKB:P19491"}
{"id":"be0c3683-2322-4224-b3b7-80d8a377fc2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CKS724B66O","predicate":"biolink:affects","object":"NCBIGene:5724","sources":[{"id":"urn:uuid:fbb96884-e3c6-46ff-9e21-0aef5e105ab5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6078","original_object":"UniProtKB:P25105"}
{"id":"55d2c75d-f9a4-44e8-85a0-0cb6478e616d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z7354TW4BM","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:503b5450-b47a-40b0-a32c-04439551a607","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3368","original_object":"UniProtKB:Q15722"}
{"id":"159cadc5-734e-4c83-a855-d14e12484c82","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755180","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:b42dc590-81e0-4aaa-be3e-d0c447c956e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6176","original_object":"UniProtKB:P32247"}
{"id":"5ac2419f-b108-4f57-bf52-6da13b31cd13","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N488540F94","predicate":"biolink:affects","object":"NCBIGene:9429","sources":[{"id":"urn:uuid:9e4a8cdc-b515-4b8e-81b1-b4d5964a0a03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13578","original_object":"UniProtKB:Q9UNQ0"}
{"id":"a1b62a07-a4af-4cd3-91b4-7da202c53527","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92361","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f93c0df1-07da-4f95-babc-938d62c37a06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:405","original_object":"UniProtKB:P30542"}
{"id":"76c5b04c-db98-4a85-8093-476f4a259094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2705","sources":[{"id":"urn:uuid:4b93dc26-fb97-422a-ab0b-9c5a087ef9a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P08034"}
{"id":"89230e65-6759-451c-b559-d1f99cc7a003","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:fc3ce983-e444-4abc-82a6-a80369df4fca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P35348"}
{"id":"03ac4a62-3552-4cbe-8346-a3893afce015","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:350ebead-5e99-446b-bd91-a70edb5b829d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P50406"}
{"id":"e6552baf-21fe-43cb-932f-cbded9ddabf0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80656","predicate":"biolink:affects","object":"NCBIGene:6096","sources":[{"id":"urn:uuid:b6992ea6-1b44-4640-b5ed-2765aa002925","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2741","original_object":"UniProtKB:Q92753"}
{"id":"c1c3daeb-8d53-4791-8fbb-f8650bf07e53","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3P63ZTE3OY","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:050ed9e7-9203-4dc5-a408-2e8aae908ee2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10618","original_object":"UniProtKB:P16234"}
{"id":"1a6c6e8a-7cea-486d-ad61-d4487c832fb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311254","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:d31b75b1-29f3-486d-8dc6-4e612a2b6a8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4087","original_object":"UniProtKB:P46098"}
{"id":"b5540daa-f446-4285-bd40-ca7515a655a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145925685","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:8f614411-6b6b-476b-8738-c673fd1eab64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10597","original_object":"UniProtKB:Q9UHD2"}
{"id":"963fbfa8-6249-4a91-8c4f-493cf6fad542","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11691555","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:da393743-e6b7-4c60-9664-e5c7e335a7cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1319","original_object":"UniProtKB:Q99705"}
{"id":"d4e97ec9-ba9c-480a-859b-d20c687f9614","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9852253","predicate":"biolink:affects","object":"NCBIGene:6869","sources":[{"id":"urn:uuid:4f61372c-0334-4061-9dd5-167b678691ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2109","original_object":"UniProtKB:P25103"}
{"id":"d9a6b065-e824-4d20-816e-f92ea8686b01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3181","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:441e6196-0079-4941-a291-5c2004afd75c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:35","original_object":"UniProtKB:P19020"}
{"id":"58fb68df-cfd4-4e45-91e1-92c3e2ba785d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3219","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:69fb35dc-5f43-4ea0-9a04-c5c257f8d3be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7135","original_object":"UniProtKB:Q01959"}
{"id":"978031ff-3efc-4bb5-8200-e00d7315aa4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:52670832","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:8b00eadf-c6f9-4d31-afc6-c668d9e47a94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7524","original_object":"UniProtKB:P25440"}
{"id":"3d1f537a-5d6b-4cf3-b055-417f8764ae24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:133172","predicate":"biolink:affects","object":"NCBIGene:53831","sources":[{"id":"urn:uuid:4e2d9753-839c-4bf5-83ae-b32dc902e468","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5847","original_object":"UniProtKB:Q9NQS5"}
{"id":"7362bf14-4794-4434-85b6-da1bc917cf9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232526","predicate":"biolink:affects","object":"NCBIGene:6198","sources":[{"id":"urn:uuid:96accb09-94ee-4767-92b2-cebf802813e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8036","original_object":"UniProtKB:P23443"}
{"id":"8118d3aa-f539-42e3-94a5-69fd58cd5726","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11125","predicate":"biolink:affects","object":"NCBIGene:2984","sources":[{"id":"urn:uuid:a0692061-f828-44b9-b744-7202cfd1957c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11125","original_object":"UniProtKB:P25092"}
{"id":"dae015e0-f2dd-4cd3-84ad-adf210911d03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31236","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:fa2b0a05-8314-486d-a3a9-6b15cc94daa3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:34","original_object":"UniProtKB:P28223"}
{"id":"81a03c26-a7c2-4505-b96c-0bbdd4044693","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL5095105","predicate":"biolink:affects","object":"NCBIGene:1584","sources":[{"id":"urn:uuid:bd355ce4-533d-42bb-bb76-3d149a1a47f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13883","original_object":"UniProtKB:P15538"}
{"id":"ce889442-9b87-44b0-94ce-4d0825e24b21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8336","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:ff304ed8-5f8a-4ce7-ab45-3ad0b4947e2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8336","original_object":"UniProtKB:Q8TDU9"}
{"id":"1b08209c-f6c7-431a-9761-0c88e78050ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35255","predicate":"biolink:affects","object":"NCBIGene:89822","sources":[{"id":"urn:uuid:86a64cd1-87de-4594-8ba3-31f10d7f01b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2503","original_object":"UniProtKB:Q96T54"}
{"id":"123c5647-5cf1-458d-be79-bad6d65047f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91421","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:df10f110-39c4-44e2-9751-10525723dab6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8015","original_object":"UniProtKB:P49841"}
{"id":"3949129f-fd28-4481-bebf-88d018804891","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2029","predicate":"biolink:affects","object":"NCBIGene:6751","sources":[{"id":"urn:uuid:2514d508-565c-4011-8bbf-44a3918b07d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2029","original_object":"UniProtKB:P30872"}
{"id":"0252a724-c674-48de-9684-097adc38dd44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35697","predicate":"biolink:affects","object":"NCBIGene:310645","sources":[{"id":"urn:uuid:5feee367-6d47-4b95-a68d-10f40aedfca0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3203","original_object":"UniProtKB:Q5RK24"}
{"id":"e2e73c80-2546-41f6-a41a-dad4cd115b8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8QR88H79VX","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:6d7eacc1-6ba3-438d-a6ba-632559417c66","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9600","original_object":"UniProtKB:P36888"}
{"id":"560b11bc-7600-461c-9db8-759872c53ada","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"UniProtKB:P31388","sources":[{"id":"urn:uuid:60078261-c1a7-45e0-99bf-30d01fe34689","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P31388"}
{"id":"e76c580a-506f-41c1-b696-97f9c5b4532a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1578","predicate":"biolink:affects","object":"NCBIGene:366274","sources":[{"id":"urn:uuid:a9ef312f-bee1-4080-8c62-951cb8083439","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1578","original_object":"UniProtKB:P20789"}
{"id":"3ae0deb3-2ce5-40e9-8fe3-d46a48e17812","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1533","predicate":"biolink:affects","object":"NCBIGene:66024","sources":[{"id":"urn:uuid:bb298160-5270-49e2-bb12-6490661ea354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1533","original_object":"UniProtKB:Q9ERC0"}
{"id":"9886d5f7-368b-4f63-af91-1763102d7783","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49575","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:d829d6ca-5c4c-4f0a-b4bb-53fc018ad23c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3364","original_object":"UniProtKB:P34903"}
{"id":"9b22ff53-9b7b-44c6-8cd4-22bec7255308","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68379135","predicate":"biolink:affects","object":"NCBIGene:308408","sources":[{"id":"urn:uuid:bc6a5c05-1214-4f8a-a520-c6e0c14b96ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10206","original_object":"UniProtKB:Q4KLH9"}
{"id":"492ec2c2-0160-4c4d-a20f-e5035eadd7fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11672774","predicate":"biolink:affects","object":"NCBIGene:11255","sources":[{"id":"urn:uuid:f3ac5f92-7ad8-4143-8ad5-b11dabae6086","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1245","original_object":"UniProtKB:Q9Y5N1"}
{"id":"21c8ea59-f1fd-49ea-9ec9-9ac3cbb72090","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44461899","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:033c389f-c14f-46d3-b399-a52a73f74b8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3028","original_object":"UniProtKB:P51639"}
{"id":"5a2f1851-f2e8-4b14-86bc-2893e0c83809","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167658","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:1ed02e8e-80a6-49c3-9424-098677061068","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7883","original_object":"UniProtKB:P04626"}
{"id":"8335a2a8-cd0b-43be-8935-5ce2c8f756d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2210","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:f1b41248-7749-4923-9c24-2bb6ed344ed6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2210","original_object":"UniProtKB:P47901"}
{"id":"19b7feeb-b65d-4f8b-8f33-698cccdd6a70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:c16bd0ca-ca11-4144-ada4-cbeb5ba38605","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P28647"}
{"id":"3f6f8c00-f00a-40f5-8f76-1d32d576a9f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JT21Y57650","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:4db69cc2-6176-4db2-b180-ad5b3e830b2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:626","original_object":"UniProtKB:P28336"}
{"id":"52371994-4677-45ec-b6fd-3b5965fe9c2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230483","predicate":"biolink:affects","object":"NCBIGene:10196","sources":[{"id":"urn:uuid:2456b6d5-8f3f-4d3d-8e78-65a40e2c084e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8955","original_object":"UniProtKB:O60678"}
{"id":"ad23bebe-bbef-467b-a3f7-29f9d17be7aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44237094","predicate":"biolink:affects","object":"NCBIGene:1198","sources":[{"id":"urn:uuid:ae915f00-8155-4c6a-864b-621c01e37bfe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8055","original_object":"UniProtKB:P49761"}
{"id":"c1ea8da0-5aa7-43d6-8063-2e71e370e0a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:584e604d-b9b5-46f1-8c9b-b36f1a72d206","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:O95835"}
{"id":"0b20e8cc-6b58-4205-bac6-62fc5e74b39f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:582b73af-69f9-406e-9aec-d000eac03cea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:O00222"}
{"id":"fcc411f9-dc5c-4ac6-8db2-5d9ce16d9e40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162365111","predicate":"biolink:affects","object":"NCBIGene:140609","sources":[{"id":"urn:uuid:4678a952-742f-45b3-a17d-09d92da7e28f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13227","original_object":"UniProtKB:Q8TDX7"}
{"id":"d246e333-0e2e-48d8-9f93-567354bba06d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A26QO95U37","predicate":"biolink:affects","object":"NCBIGene:13040","sources":[{"id":"urn:uuid:67028175-f884-4be6-bd35-e844f8deae64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9855","original_object":"UniProtKB:O70370"}
{"id":"1aa81826-fcac-4cd2-afbe-e68ebc2c459c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:441294","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:682df283-516f-428d-9630-f7c563d6bf18","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:1862","original_object":"UniProtKB:P23416"}
{"id":"3c68b802-f324-4d05-a1ad-174c6cbf65aa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10025114","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:6702bf67-e7f8-4096-ab88-96b41c42f3c1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4079","original_object":"UniProtKB:Q14957"}
{"id":"95c2d7b0-41ec-454c-9450-f0a1c9132642","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6603904","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:17a5821c-56e6-44e5-a1c3-88a4fa155b3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:506","original_object":"UniProtKB:P35368"}
{"id":"91583785-3f8d-458b-9674-29072c33fb71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72950074","predicate":"biolink:affects","object":"NCBIGene:3758","sources":[{"id":"urn:uuid:d7f16084-c35c-4228-9df7-467a79d26b15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12780","original_object":"UniProtKB:P48048"}
{"id":"2d9bf9a1-3069-4316-803c-b789e859a0a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16762479","predicate":"biolink:affects","object":"NCBIGene:5031","sources":[{"id":"urn:uuid:cc2dc9b8-4731-4092-a588-c2f12ae31871","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11452","original_object":"UniProtKB:Q15077"}
{"id":"2a2ef6e9-bc0c-4059-91ec-ff3628cc8623","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611885","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:df994ce5-f785-4cf1-9d3a-e9dc4c16e044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9961","original_object":"UniProtKB:P42338"}
{"id":"d0e26c53-c5a4-402d-8b4a-035c0495923d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6182","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:1494e55e-97c6-4363-959c-17aad6764dfd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6182","original_object":"UniProtKB:P52500"}
{"id":"2aff9790-c058-4e85-aeed-3c630d2f45ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6706","predicate":"biolink:affects","object":"NCBIGene:1136","sources":[{"id":"urn:uuid:9ecf8194-d087-4b9e-bcf8-ef26e03edb27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3990","original_object":"UniProtKB:P32297"}
{"id":"1ae590ec-de84-4cc8-a746-3570b09df981","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177844","predicate":"biolink:affects","object":"NCBIGene:25075","sources":[{"id":"urn:uuid:5bbe4fb5-a701-4540-9cf0-e8f9d9a271b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10446","original_object":"UniProtKB:P28564"}
{"id":"73ad4f77-a4bf-49dd-bf58-aad9754bdf5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16135415","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:c39c464f-354b-4e29-b99a-c9e47e1afc22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2536","original_object":"UniProtKB:P54282"}
{"id":"bb1fae88-251f-4fbb-a02b-189ed1f071f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W0ZE0NT8IF","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:35ed45c7-8820-43d9-a604-49117e24eed0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11154","original_object":"UniProtKB:P29274"}
{"id":"8141689b-5c57-4ddd-95f7-54d3562398f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6918320","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:6fc7fa15-f977-48ed-8d07-23cff4415b0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2252","original_object":"UniProtKB:P30559"}
{"id":"e21bfeca-9b11-483c-bdae-22cbb540f4fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N986NI319S","predicate":"biolink:affects","object":"NCBIGene:834","sources":[{"id":"urn:uuid:1eb90d8b-6868-446c-b498-8e00c5126953","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6467","original_object":"UniProtKB:P29466"}
{"id":"6245ef40-ccd1-4184-bded-39faec0abc9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:cf0ae3e4-ea04-4192-95db-0871ea088bf4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P08908"}
{"id":"d337de23-99bc-4006-bb9d-68ec4cd60fd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:69478","predicate":"biolink:affects","object":"NCBIGene:20264","sources":[{"id":"urn:uuid:45929638-d7b8-419e-b7eb-34d03bb1ab3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4150","original_object":"UniProtKB:Q6QIY3"}
{"id":"4dc322f7-5e8c-466b-a37a-9be3623bd741","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9802","predicate":"biolink:affects","object":"NCBIGene:958","sources":[{"id":"urn:uuid:325876a6-fc60-4e05-9782-13e7a4a1e896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9802","original_object":"UniProtKB:P25942"}
{"id":"dc125763-ba70-48ee-9d64-8d78868b53cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2045","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:f9bed649-c929-40df-8b52-b71fc67eb975","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2045","original_object":"UniProtKB:P30874"}
{"id":"d37a4bce-f915-4704-83e5-0e6a6668bcc2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9791","predicate":"biolink:affects","object":"NCBIGene:5168","sources":[{"id":"urn:uuid:c1691885-4e55-4151-9608-a3653a7bdc85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9791","original_object":"UniProtKB:Q13822"}
{"id":"ad4d1b0a-8dc5-423e-a8c2-e5846230d8d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66665322","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:a99f8d6a-eebb-4d0c-a4e2-49f10938c4b5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9822","original_object":"UniProtKB:P56817"}
{"id":"07f796b0-fb91-4218-8d4d-d36766964b91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9841259","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:a0ac1f28-5131-4bc1-b449-bed736f8acc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9005","original_object":"UniProtKB:P41143"}
{"id":"0c1d3df5-f22f-4f05-9a89-03f8aa0fc6d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10458325","predicate":"biolink:affects","object":"NCBIGene:2050","sources":[{"id":"urn:uuid:115252d4-ccec-41c9-89b7-f3cc75792748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7944","original_object":"UniProtKB:P54760"}
{"id":"7ae66124-abab-42ee-b29c-0d555ca6191c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11443899","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:e71107b6-da6f-44af-82a7-f88895a7dcf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2076","original_object":"UniProtKB:P32745"}
{"id":"f3bb2fc0-46d1-43c9-b71c-1aafe0937c9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EOB0N7BOY4","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:23b496db-8193-4a49-8af4-c5f2e75b1bca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13215","original_object":"UniProtKB:P11309"}
{"id":"cadead94-4d29-4a0a-a7f6-11960a04035f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10218379","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:0d6ca7ea-4ab0-456b-9242-c13c8dae8954","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:578","original_object":"UniProtKB:P21730"}
{"id":"d5e27f8e-89cf-4161-8a4e-0d7eccb4aa0d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1866","predicate":"biolink:affects","object":"NCBIGene:10887","sources":[{"id":"urn:uuid:1b2b6b34-97dd-4c1a-bdd3-2b296f0f82f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1866","original_object":"UniProtKB:Q8TCW9"}
{"id":"cf80aa27-ce6c-4b46-b080-a1e0640fb722","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:4486","sources":[{"id":"urn:uuid:622d4eb8-82db-4d6b-9222-f3d6643f5368","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:Q04912"}
{"id":"61a6cbe8-5449-43fe-bc57-516e3a517fc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:67033699","predicate":"biolink:affects","object":"NCBIGene:9536","sources":[{"id":"urn:uuid:96583366-6943-4d0f-84f4-c60a932fbf56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9709","original_object":"UniProtKB:O14684"}
{"id":"522d0572-af42-4903-a2e7-1a4fabc0c075","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:163321087","predicate":"biolink:affects","object":"NCBIGene:4140","sources":[{"id":"urn:uuid:c5a9c5b2-887b-4668-a6a9-e54051e5aaca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12937","original_object":"UniProtKB:P27448"}
{"id":"1ff211bc-24ae-46e1-8626-f84776a8c708","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146552766","predicate":"biolink:affects","object":"NCBIGene:120892","sources":[{"id":"urn:uuid:4dbd422c-28c9-4b78-a16d-516fbe2c2731","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12908","original_object":"UniProtKB:Q5S007"}
{"id":"ce06dc0a-53be-43d7-a303-7a8396944588","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0JSR7Z0NB6","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:0cc044e6-6fb1-4c1f-ad1d-afce0c0e91e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10505","original_object":"UniProtKB:P00533"}
{"id":"1b6af959-cce8-4a6c-b04e-b4d44d90bda1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5052387","predicate":"biolink:affects","object":"NCBIGene:25505","sources":[{"id":"urn:uuid:91eba127-1352-47ae-83c0-704a232e4c96","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11231","original_object":"UniProtKB:P47824"}
{"id":"2426064b-79af-4529-9e3e-e2ce4abce99b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71364","predicate":"biolink:affects","object":"NCBIGene:12062","sources":[{"id":"urn:uuid:94f3152f-628b-4bf7-be38-0844640579f3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:667","original_object":"UniProtKB:P32299"}
{"id":"fcf74c49-ce51-4e93-97ef-88db8e297326","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:ab2ebf6f-2109-4c4a-a26f-7c39e434a2d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P34969"}
{"id":"b338bbaf-604e-4cbb-8367-4968c94a10e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176844","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:98daf4c9-8323-43e2-8a2c-f25e47e913dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8275","original_object":"UniProtKB:Q9UGN5"}
{"id":"6f009b60-4a57-4ea2-9fe2-ef7a5387a33f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44358908","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:99983647-863c-4573-a5f4-41f43b1770fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:344","original_object":"UniProtKB:P08173"}
{"id":"a53efc31-8eb6-4654-98b2-17a793713da5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91541","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:d6b26220-5b2d-442b-acf3-6a7201f65052","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:330","original_object":"UniProtKB:P08912"}
{"id":"626d4180-51e2-49cb-9a52-c936bae0bf23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6074","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:50a276ec-a0cd-46a9-94b1-4cd8c5df0d2c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6074","original_object":"UniProtKB:O43603"}
{"id":"6f66b4bb-5617-4a86-9348-7a6a0dbf3e24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64187","predicate":"biolink:affects","object":"NCBIGene:1644","sources":[{"id":"urn:uuid:3289af2b-e6af-4120-a1d4-87ea161ee98c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5150","original_object":"UniProtKB:P20711"}
{"id":"0def20f6-a0fc-42ed-97ec-ea53ff7b8f23","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17026","predicate":"biolink:affects","object":"NCBIGene:4306","sources":[{"id":"urn:uuid:b9da8b72-83ae-454f-83c5-93b7d1076206","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2377","original_object":"UniProtKB:P08235"}
{"id":"12c5eda1-351a-4ed3-99bd-edd023a474dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947025","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:f5e13384-b5ca-49b7-aa3a-c973df8274a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3005","original_object":"UniProtKB:P51639"}
{"id":"2baad6ce-b248-4576-b88e-98136fb8a44c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5160","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:5c09c81a-6593-4090-ac80-a131a514356c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13770","original_object":"UniProtKB:P17252"}
{"id":"6efc65eb-7187-4ad0-8753-3dd9ecf82917","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:02d8be55-bc63-47c0-b71d-5f78fa26554b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P34969"}
{"id":"5e49485a-951a-4973-a43e-f80cfe4efd60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519693","predicate":"biolink:affects","object":"NCBIGene:7006","sources":[{"id":"urn:uuid:3f29773a-a621-46b4-8adb-aed0e6b298fb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8148","original_object":"UniProtKB:P42680"}
{"id":"1d00a73f-dacd-44a8-8089-028957c8b0b2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90848","predicate":"biolink:affects","object":"NCBIGene:5732","sources":[{"id":"urn:uuid:0c0f9a67-3ca7-46f8-8342-603fa4bd8fe5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5852","original_object":"UniProtKB:P43116"}
{"id":"17cb2731-7315-477d-a553-897cf95a201e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74221499","predicate":"biolink:affects","object":"NCBIGene:1803","sources":[{"id":"urn:uuid:c4143b8c-91ae-4b4c-8d23-8df6ce83f8c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13952","original_object":"UniProtKB:P27487"}
{"id":"21d5fc26-3af1-4bed-9b12-921c7948db38","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:455812f0-d33c-4f2e-a4a7-af3be6adbe76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:P70597"}
{"id":"1890a94e-293f-4354-b6b1-fd4fafc1901d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232977","predicate":"biolink:affects","object":"NCBIGene:10038","sources":[{"id":"urn:uuid:025c3a87-cf2a-48d7-ba71-3262fda9ee74","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10671","original_object":"UniProtKB:Q9UGN5"}
{"id":"c43cd9cf-6957-454f-89f2-77a0893c2d0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:359468","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:09dd73bc-531d-4096-8d4f-9202249c70db","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13461","original_object":"UniProtKB:P0DTD8"}
{"id":"6ef47740-caf9-4172-ae30-56d0bbb9d2c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:359468","predicate":"biolink:affects","object":"UniProtKB:P0DTD8","sources":[{"id":"urn:uuid:c3068de1-c8f3-47ac-8462-a4bff2cb0023","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13461","original_object":"UniProtKB:P0DTD8"}
{"id":"e67228ce-1be4-48b3-b97d-d1f3e1e56294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9J13XU96Z1","predicate":"biolink:affects","object":"NCBIGene:7465","sources":[{"id":"urn:uuid:b93d7e97-f5c3-4fc1-be3f-cee4a393034d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11731","original_object":"UniProtKB:P30291"}
{"id":"db4dbe99-4f0f-4af4-bfd7-6de5e8187b7e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92511","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:312fb59a-d740-44df-9aad-bfb3b5cedcd2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7206","original_object":"UniProtKB:P35367"}
{"id":"b8686314-dd84-4b0e-81ce-c71dad5a8988","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133797","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:d124e1f6-3e38-4b44-a672-9090457c1012","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2311","original_object":"UniProtKB:Q92952"}
{"id":"371db248-c4d7-4705-a6a5-5a8c38501a6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L7451S9126","predicate":"biolink:affects","object":"NCBIGene:6403","sources":[{"id":"urn:uuid:9f9be0b4-fca9-4531-b109-b70136bab031","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:10550","original_object":"UniProtKB:P16109"}
{"id":"57731eb3-8cd8-472b-8ccb-3563cc21f276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N1GRK350ZM","predicate":"biolink:affects","object":"NCBIGene:51135","sources":[{"id":"urn:uuid:20b063be-26b4-4115-bf46-3a5fcc0fadbe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11415","original_object":"UniProtKB:Q9NWZ3"}
{"id":"fd045012-5629-43db-9d20-6cafe9415ed1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16828","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:0f9e10c6-e12c-43fe-bab1-3c7366d5e0b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:717","original_object":"UniProtKB:Q7Z2H8"}
{"id":"92ab199e-65ba-4b5f-9fa8-628323e84c2b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7785","predicate":"biolink:affects","object":"NCBIGene:1438","sources":[{"id":"urn:uuid:77e2071e-6f92-4d8e-87bf-1976eec44d9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7785","original_object":"UniProtKB:P15509"}
{"id":"90f0cc0b-b6e3-454c-aa6f-f9db946f8afd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64317","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:29288934-e3d4-40e7-8f62-fcc7966fb472","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:536","original_object":"UniProtKB:P08588"}
{"id":"daefeff4-1128-40ce-b18e-529970716ff2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11192346","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:36c05d30-696c-4bb1-ba25-604cc199147e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9032","original_object":"UniProtKB:P41597"}
{"id":"1bce7035-c3c3-4be5-add5-3114c1e863e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52289","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:f6f6019c-4ff4-40fe-b567-aa23494b7067","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6060","original_object":"UniProtKB:P48736"}
{"id":"82572bfc-d6c0-40e4-9cfc-4670b25abccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2PRJ7DX38T","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:048de524-698e-4f81-9092-c1be9ec5b8ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12708","original_object":"UniProtKB:P11309"}
{"id":"e28a8aa5-d2a2-4eea-977f-09f25cf71ebd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:82814","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:879587c8-c051-4677-ac53-d1040192d95e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2512","original_object":"UniProtKB:P22002"}
{"id":"66badaa7-e93d-4272-92b5-45c89686cfd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230489","predicate":"biolink:affects","object":"NCBIGene:5915","sources":[{"id":"urn:uuid:4005b80d-e91d-47c7-aa03-4daf7d095f1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2651","original_object":"UniProtKB:P10826"}
{"id":"1c1cf031-126f-45e9-b999-6878a17c86b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3000479","predicate":"biolink:affects","object":"NCBIGene:9975","sources":[{"id":"urn:uuid:57a797aa-a283-43dc-a3b3-0ab2a2c9cd6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8902","original_object":"UniProtKB:Q14995"}
{"id":"8cd370c9-3d5e-4d04-9719-0f496d36d903","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118273623","predicate":"biolink:affects","object":"NCBIGene:6336","sources":[{"id":"urn:uuid:af8b3914-0f75-4805-a853-507b2adf5f35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12002","original_object":"UniProtKB:Q9Y5Y9"}
{"id":"bb5aede0-a710-449e-a843-ae155aee9e06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93224","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:73b63383-0266-445f-813c-1408df26c4ef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1378","original_object":"UniProtKB:P31421"}
{"id":"cb74ddde-a464-4978-8873-d4c1bf28e616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:10052","sources":[{"id":"urn:uuid:77e4bc36-2457-43ce-9c9d-d292e6bda25e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P36383"}
{"id":"37b4dad5-c804-4d3e-8cd4-4b102421f9c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93263","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:173eb0c6-8e42-44bd-9179-527047b23cbc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3991","original_object":"UniProtKB:P36544"}
{"id":"b1f0c2d5-be92-4649-b020-de995a8c469f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4873898","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:20f94b29-12e5-43d9-8080-526d97ad7c31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11733","original_object":"UniProtKB:Q99685"}
{"id":"c1a51f88-785f-4b2d-bb40-03a919717d76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:UT87RB8I1V","predicate":"biolink:affects","object":"NCBIGene:151","sources":[{"id":"urn:uuid:0cb64654-0230-47d6-ad45-ae0c3ce1b0b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12577","original_object":"UniProtKB:P18089"}
{"id":"f3fd7b24-cb65-40d2-9876-5fbff00b98ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232556","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:2abc0f21-eda0-4e1f-a612-ad3ba8af8c24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9039","original_object":"UniProtKB:P22455"}
{"id":"0f86af2a-b815-4175-a6c3-d3f853e4a9b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168433298","predicate":"biolink:affects","object":"NCBIGene:18390","sources":[{"id":"urn:uuid:c7f66139-173c-422c-a0d0-0026139c1db7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12727","original_object":"UniProtKB:P42866"}
{"id":"f391a860-0ba3-4e96-9e13-112ae5e3d873","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:180876","predicate":"biolink:affects","object":"NCBIGene:3776","sources":[{"id":"urn:uuid:33c971ef-f20f-419f-a1fe-8cdfe764a061","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:208","original_object":"UniProtKB:O95069"}
{"id":"539228a9-a6e2-4abd-ae41-6a9ad43afaae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155749520","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:458e4282-0d59-46a7-94d9-4394154c1826","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12059","original_object":"UniProtKB:Q05655"}
{"id":"4b96dfa7-7653-49c0-89f0-bf438dc1f14d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233291","predicate":"biolink:affects","object":"NCBIGene:25007","sources":[{"id":"urn:uuid:ece94b68-1279-46a0-b4a6-f0eac45e738d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2111","original_object":"UniProtKB:P16610"}
{"id":"0c812d51-8523-42a8-96e6-7b7b342f57a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164886635","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:667a390b-876c-4182-806f-b23ea7956f09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12062","original_object":"UniProtKB:P42338"}
{"id":"3e0d0422-2ce3-4fe7-9b03-657be56c2540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6085","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:12e8a548-5963-4a68-8477-ac5fd3f00fad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6085","original_object":"UniProtKB:Q62805"}
{"id":"ec1a7dac-e4cc-4cfa-a6ab-c224ffe1e1fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138608760","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:b276d2b1-0b90-4cbd-b103-5ec8986b7538","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11356","original_object":"UniProtKB:P50613"}
{"id":"ef45344c-5e85-41e6-acf7-62c454ec16cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N8Q12KU2SW","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:e92e4cd4-90dd-4fc6-a65e-d4c81c146c5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11191","original_object":"UniProtKB:P00519"}
{"id":"51909618-4c49-4761-9a5a-bf64e7c5e04d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63618","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:97551337-cd90-46ea-9fe2-06530da422a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2953","original_object":"UniProtKB:P51639"}
{"id":"3f67e84f-a60a-485a-aec8-1924ff63cadc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL69234","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:7422ecf2-fcd9-4bf1-9111-4bcc98cb2fc8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1725","original_object":"UniProtKB:P47900"}
{"id":"ddc5a331-71e0-46e0-b8e2-0734a560eea1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9B0H171MJ","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:8ee1b745-f744-4ad6-9ee0-b541052ba2a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9785","original_object":"UniProtKB:P21802"}
{"id":"26600acb-dbdd-467f-87b3-3485441e9ad0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17115","predicate":"biolink:affects","object":"NCBIGene:2902","sources":[{"id":"urn:uuid:3645d8c5-0e9f-404c-9f86-2164f94eee1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4171","original_object":"UniProtKB:Q05586"}
{"id":"c9b33eb9-218d-4eea-a6d5-ba2a60885cc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86280676","predicate":"biolink:affects","object":"NCBIGene:338557","sources":[{"id":"urn:uuid:2a6b6f3d-8593-4f68-9d07-ddfeb0a14271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11195","original_object":"UniProtKB:Q5NUL3"}
{"id":"b688c74a-4703-46ab-8f2b-da31bc754ae0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:136254272","predicate":"biolink:affects","object":"NCBIGene:8445","sources":[{"id":"urn:uuid:232f7e97-66d3-48dd-919d-65a0a16bafad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8171","original_object":"UniProtKB:Q92630"}
{"id":"2b6f94c2-31a5-4ca2-ab9e-5889baab5609","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H62AOA2IYF","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:f6d35de5-a539-47b8-b1a5-3ab2f200c20a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2740","original_object":"UniProtKB:P51449"}
{"id":"47d60e90-6c14-48e7-8974-a553a31d1601","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118720630","predicate":"biolink:affects","object":"NCBIGene:51752","sources":[{"id":"urn:uuid:d8bd3f4b-c894-4e0a-b5fe-5b2bdb6bc6a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9682","original_object":"UniProtKB:Q9NZ08"}
{"id":"0a61bbad-6800-44d6-8c47-9802a7f88b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10472","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:241779dc-f9e6-4034-9e79-e47d50373ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10472","original_object":"UniProtKB:P35968"}
{"id":"b2d6243b-4451-4f41-9f0c-e5581d0f4782","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95071","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:5bf4aae1-a64d-43d2-bd01-f0d030e93910","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8365","original_object":"UniProtKB:O15379"}
{"id":"0c223186-7590-4f19-9a26-2d4c9f06b8ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:07Z1P4981I","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:20d566dd-a3ad-41c3-8883-3ec1910df102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5653","original_object":"UniProtKB:Q8TDV5"}
{"id":"55684319-913a-422a-8482-b285468141f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817483","predicate":"biolink:affects","object":"NCBIGene:29235","sources":[{"id":"urn:uuid:41197b63-9912-4426-aae7-7707f6ea6162","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6094","original_object":"UniProtKB:O88626"}
{"id":"a8d2a6f1-5cf0-47c5-9384-f56ebac774d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176744","predicate":"biolink:affects","object":"NCBIGene:19219","sources":[{"id":"urn:uuid:2d98a29f-d710-4d05-b7ff-ab54bc3f1d71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1925","original_object":"UniProtKB:P32240"}
{"id":"9abade0b-12f1-48b2-91f3-87a1f918edf8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10832101","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:4e0dd2b6-65e1-40ff-8e28-3781125b6945","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:475","original_object":"UniProtKB:P0DMS8"}
{"id":"dad41f8a-8579-4dfb-8997-4fc4ad24874f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6367","predicate":"biolink:affects","object":"NCBIGene:24766","sources":[{"id":"urn:uuid:e5641731-3f9a-4fad-a584-93da502df95b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2622","original_object":"UniProtKB:P04775"}
{"id":"0644fdd2-c23a-4cf0-b51f-bc3806b7d7a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847194","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:0214487f-164f-4d5c-bea8-7cf1286d71be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:16","original_object":"UniProtKB:P28222"}
{"id":"f58e5f18-afaa-408a-80e6-ae6f3b1c09e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93701","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:69a059aa-46b5-4f24-9ac8-b7ec12b22b54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2200","original_object":"UniProtKB:P30559"}
{"id":"fd220511-9b94-42b8-aad1-0528c5ffaf24","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50648","predicate":"biolink:affects","object":"NCBIGene:6258","sources":[{"id":"urn:uuid:8b8ec9c7-c363-4260-b3fc-31741bead1bd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2645","original_object":"UniProtKB:P48443"}
{"id":"9f1db9cd-9f9c-48bf-8067-a915c3497d35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311225","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:0fb04429-f4f8-4719-b2e3-fcea67a880fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1918","original_object":"UniProtKB:P34980"}
{"id":"2fd45b49-b489-425c-ba4c-12fe0a7bbdfd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:53115","predicate":"biolink:affects","object":"NCBIGene:100911796","sources":[{"id":"urn:uuid:8faee314-f4ca-463a-ad86-38998b36cb2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5609","original_object":"UniProtKB:P28647"}
{"id":"9a0bd73a-53b7-473a-a3cd-f1ce5e4fe536","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9889212","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:c48d6d28-0ffe-4e8e-8c4a-fc69cff283bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4260","original_object":"UniProtKB:Q13224"}
{"id":"5755ca39-7089-456f-93d5-e83df7cdaee8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91455","predicate":"biolink:affects","object":"NCBIGene:5580","sources":[{"id":"urn:uuid:1c5914a5-e6dc-4a3e-992d-759745754acf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5192","original_object":"UniProtKB:Q05655"}
{"id":"07e0a4be-5245-43df-9d5b-fe54b61c1160","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5428913","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:4836254c-e796-4020-81c3-105dfc403a14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8545","original_object":"UniProtKB:Q14831"}
{"id":"9239590b-4c20-419c-9076-4deda9d9606c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N8VKI8FPW0","predicate":"biolink:affects","object":"NCBIGene:10419","sources":[{"id":"urn:uuid:715093af-c0a2-4289-a453-8cb10b1eddd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11749","original_object":"UniProtKB:O14744"}
{"id":"4b1b1ce8-f641-4e7f-b390-482d6fc4ad37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FA554TW3UP","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:5b72e74a-b28b-4af8-ba4a-62837e3de0f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9004","original_object":"UniProtKB:P35372"}
{"id":"3ebf1368-ec3b-4dcb-98ae-672aababd5f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2622","predicate":"biolink:affects","object":"NCBIGene:259296","sources":[{"id":"urn:uuid:e295d89c-cdd2-4e1e-85ad-d6b13869fefd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12459","original_object":"UniProtKB:P59544"}
{"id":"d9dccba9-0c45-4af0-80fc-9bd1e86787e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:fd7d8971-b097-4251-a98e-f4b6361996cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2486","original_object":"UniProtKB:O35433"}
{"id":"416aa547-8435-4dfe-a0ab-698e66f9abbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:10021","sources":[{"id":"urn:uuid:f480cc9f-7c8b-4e41-b6bd-b03cb5197a2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:Q9Y3Q4"}
{"id":"39463937-72f6-4add-9469-89a2cb7a2d35","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137530063","predicate":"biolink:affects","object":"NCBIGene:1557","sources":[{"id":"urn:uuid:bfb7be0c-3d46-413d-8a56-2a33301e3d41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12037","original_object":"UniProtKB:P33261"}
{"id":"9e4bd6f6-50f0-4cb3-a4a9-9a1b304976ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156358323","predicate":"biolink:affects","object":"NCBIGene:1022","sources":[{"id":"urn:uuid:826ac03f-e043-49e0-aafd-64d2a50f0ad0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13499","original_object":"UniProtKB:P50613"}
{"id":"adf489d3-c02f-4e06-b2a6-6e8fccef8c89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:988cb09d-0730-4eb9-9844-5a5f5cca6a30","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P14416"}
{"id":"1d7cd022-cffc-4982-a7e0-c787320e1d22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MM6384NG73","predicate":"biolink:affects","object":"NCBIGene:2697","sources":[{"id":"urn:uuid:717c1a73-db78-4f4e-b928-428662e7b00e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4151","original_object":"UniProtKB:P17302"}
{"id":"9158d381-3576-4dfd-b886-a5bd05205ee7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7925","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:40f52b01-085d-4e6e-9e74-f760cb8319f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7925","original_object":"UniProtKB:Q9GZQ4"}
{"id":"b6cd811f-6d31-46b5-87c2-157b64266947","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177643","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:b2fbcca1-33c3-406a-94fe-e820c6ffdcc4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1956","original_object":"UniProtKB:P43117"}
{"id":"c9c5230e-d87c-40cc-ac26-3018b5e46a6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:595","predicate":"biolink:affects","object":"NCBIGene:24182","sources":[{"id":"urn:uuid:0b61bc20-af70-43d6-8685-3eecdbb0ac9e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:595","original_object":"UniProtKB:P35351"}
{"id":"f28e1261-7978-4b2e-816e-3ad43d10b826","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72200352","predicate":"biolink:affects","object":"NCBIGene:5292","sources":[{"id":"urn:uuid:d6e25ff3-221e-4e67-b041-0a6f3af54fd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9373","original_object":"UniProtKB:P11309"}
{"id":"8f116d83-ca78-4094-a566-60272a750928","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:JCL936W835","predicate":"biolink:affects","object":"NCBIGene:5291","sources":[{"id":"urn:uuid:b16afaa4-2747-4992-bd23-4b229a1bc108","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7743","original_object":"UniProtKB:P42338"}
{"id":"649238c1-a236-4597-a65a-cc0b732e2a0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:158617","predicate":"biolink:affects","object":"NCBIGene:779","sources":[{"id":"urn:uuid:367fb69a-4724-45be-96d6-36e4dd0be904","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2733","original_object":"UniProtKB:Q13698"}
{"id":"9817f469-23ee-4651-8094-d00a208ec52d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21117106","predicate":"biolink:affects","object":"NCBIGene:2898","sources":[{"id":"urn:uuid:e8b24eca-08ae-4908-bd6e-0e4055b757ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4317","original_object":"UniProtKB:Q13002"}
{"id":"1d48e188-fdc6-4400-9521-0185f3d68519","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440621","predicate":"biolink:affects","object":"NCBIGene:4157","sources":[{"id":"urn:uuid:5e2044be-a8ff-4885-97dc-da91d91aa6a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1325","original_object":"UniProtKB:Q01726"}
{"id":"dff3fa7c-70d2-4b10-bdaf-f4513bd3c14b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6323481","predicate":"biolink:affects","object":"NCBIGene:575","sources":[{"id":"urn:uuid:335f60fe-4dac-4753-a4fc-75660d9b9509","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3638","original_object":"UniProtKB:O14514"}
{"id":"5ed47b1c-a041-411a-a6af-b4aae31eaf61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11523834","predicate":"biolink:affects","object":"NCBIGene:24414","sources":[{"id":"urn:uuid:dcb921b2-3f71-42ed-bc84-07cca5964146","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6207","original_object":"UniProtKB:P23385"}
{"id":"2ddb7582-464e-44f5-9585-c96b07f24ad8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:1af965b4-54a1-41e5-acb7-5e395f797ee1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P41595"}
{"id":"bd37723e-8b30-44d1-b8ae-0fc533378abc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8707","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:006635e5-8249-4e18-afe2-3f8912cb1b16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:50","original_object":"UniProtKB:P28221"}
{"id":"465506ac-688c-4671-8aab-b1b1e30334f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111173","predicate":"biolink:affects","object":"NCBIGene:5141","sources":[{"id":"urn:uuid:0da9584d-4582-43f2-8179-e63031eb62f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5258","original_object":"UniProtKB:P27815"}
{"id":"0686eeaf-a8c8-47ac-b0db-70aafeff2a76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NT43S9BKJ2","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:69faaff2-9670-42fb-af80-d63dae6189ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8870","original_object":"UniProtKB:P41145"}
{"id":"9b9c7606-4a16-4570-86f3-c9615d0ebe20","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122588231","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:d748570d-bc60-4056-9a87-a943cebcaf3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11073","original_object":"UniProtKB:Q8TDS5"}
{"id":"521fb5b0-0505-4eb5-a375-282bc7415432","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:70812729","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:83f6457a-81e4-4e06-8ec5-d26a92e73451","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12570","original_object":"UniProtKB:P21453"}
{"id":"d0802a65-7247-4efb-a3c2-48cc682b3e8e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49848557","predicate":"biolink:affects","object":"NCBIGene:53637","sources":[{"id":"urn:uuid:6ac23b65-33f0-4de1-b0eb-be0d017fad45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9492","original_object":"UniProtKB:Q9H228"}
{"id":"4bdca3b4-a470-46ed-b12b-f3a565774dbb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34076","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:fb357c0e-24f8-472a-8ce8-5e115f64da53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2314","original_object":"UniProtKB:Q9H2S1"}
{"id":"ba147a68-7c86-4686-adf5-94adf0648e58","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1995","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:3eb143bc-3173-4f9a-92c5-be4b7348c1a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1995","original_object":"UniProtKB:Q9HBX9"}
{"id":"3a1ca476-4094-4cc1-a789-902c2bb31c8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27882","predicate":"biolink:affects","object":"NCBIGene:2741","sources":[{"id":"urn:uuid:de8f28dd-d3bc-4667-bcaa-dcd615f3126f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2367","original_object":"UniProtKB:P23415"}
{"id":"88694296-b703-4674-a88c-06611486f327","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91409","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:0ce555b4-0459-453a-9d32-6a21e1a95ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7953","original_object":"UniProtKB:P08581"}
{"id":"fec669f5-c3e1-44cd-865a-9ca3b850f6e3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125467","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:4d8d4f2c-fd94-4404-8254-9f7e9dcc7c3b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1265","original_object":"UniProtKB:Q9H3N8"}
{"id":"2d2841a0-e0c5-4bd1-b9a6-b26d5e6814ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2426","predicate":"biolink:affects","object":"NCBIGene:9780","sources":[{"id":"urn:uuid:12d683ee-3daa-4d8e-b801-4709360eeaaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2426","original_object":"UniProtKB:Q92508"}
{"id":"576678d4-2342-46e4-aac5-523d7b891fe6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6178","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:f7b0c316-31fd-4283-991a-7e4aabf91dd6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6178","original_object":"UniProtKB:P52500"}
{"id":"135d8223-96dd-4c87-9965-f05fe75b17ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72164440","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:eda6ee39-7a61-46ba-8141-4dc51c843f6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8842","original_object":"UniProtKB:P45983"}
{"id":"e4bc5159-7c36-4e40-b656-f633fb9b6880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6474310","predicate":"biolink:affects","object":"NCBIGene:162514","sources":[{"id":"urn:uuid:55299819-6351-4a24-97d1-3110e7704608","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12548","original_object":"UniProtKB:Q8NET8"}
{"id":"a9ff7bea-4d0d-48d8-a27d-cd8d5175d5bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827343","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:193fdece-14d2-42f3-acc2-452793f57700","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2305","original_object":"UniProtKB:P46098"}
{"id":"25540e9f-dda4-476d-83d5-89a97adeae66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48292","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:3e1bd3af-f32b-4be4-a582-56fa7fb00854","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4","original_object":"UniProtKB:P28222"}
{"id":"a06341ed-3466-4c71-883a-0996f5a23814","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56973724","predicate":"biolink:affects","object":"NCBIGene:7272","sources":[{"id":"urn:uuid:418384ff-6b69-4fc5-bd2e-80b91efdae82","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9400","original_object":"UniProtKB:P33981"}
{"id":"7f389eb1-0512-418f-a100-7034a8101be5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71349","predicate":"biolink:affects","object":"NCBIGene:20607","sources":[{"id":"urn:uuid:88990e39-ea12-4d79-b57a-41dd8adcd4dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2031","original_object":"UniProtKB:P30935"}
{"id":"68034630-7e30-49a3-98bd-89488da7ef28","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5122","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:13ad65ca-43dc-485e-b678-49388e679bee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:279","original_object":"UniProtKB:P32305"}
{"id":"c515082f-eab7-468e-be7a-b3beda903f3d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13809","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:8bc80956-5447-4afd-a172-b0bcaa3188ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13809","original_object":"UniProtKB:P11362"}
{"id":"8a272e79-d87d-46a6-b73d-c34a1943f054","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:190945","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:a2b35196-ad0c-4a49-8020-ccfd20f8e23a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5766","original_object":"UniProtKB:P29371"}
{"id":"435aa681-a07a-416e-b6d7-5a72da67be75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:1afaf250-739e-462d-b559-c9a37123aa37","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P29275"}
{"id":"2c586f8e-2da9-410d-ad0d-d30483aa8a9e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:0eec7858-37ac-43a1-8151-937b7515558e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P20309"}
{"id":"e42e1679-0bc7-4e73-a8be-13015adcf45f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:139349","predicate":"biolink:affects","object":"NCBIGene:79054","sources":[{"id":"urn:uuid:78c30da1-bcee-48a2-8ded-f187c95d7b71","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2443","original_object":"UniProtKB:Q7Z2W7"}
{"id":"adcf138d-2e25-487c-87dc-272601cc534a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65326","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:d7d1044e-39a3-4163-af65-fcc3df61b8bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5682","original_object":"UniProtKB:P48736"}
{"id":"f2c040a2-4b84-40dd-a6f6-a824e7cc88de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9982767","predicate":"biolink:affects","object":"NCBIGene:1594","sources":[{"id":"urn:uuid:08974f2c-11cf-46a8-b0c1-950847c12a6d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8819","original_object":"UniProtKB:O15528"}
{"id":"0ee893a6-3254-4ab5-b5a4-fa4751861c9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53235534","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:ed6cc5ee-ccb3-4374-accc-9a78daf36a7c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5748","original_object":"UniProtKB:Q8TDV5"}
{"id":"9ecd9d38-637c-4013-8161-4e8ac07eb2ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KNM216XOUH","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:cf9eb6e5-e3b5-468a-b040-07c1bf43db86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7712","original_object":"UniProtKB:P47869"}
{"id":"c20a9083-595b-450d-be05-833be0071d3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31638","predicate":"biolink:affects","object":"NCBIGene:2852","sources":[{"id":"urn:uuid:5e8a9414-5646-4e5e-b884-802caba9a893","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1015","original_object":"UniProtKB:Q99527"}
{"id":"444b0ced-bc62-4273-baa1-e137836cecbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:22509df9-efd9-4f08-9645-a6421fcd4ecd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P30939"}
{"id":"f6ab8b96-04be-4bde-9821-b9a8117c9938","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44199427","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:3f322970-bca4-46b2-8886-6ad47cc6e3d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9077","original_object":"UniProtKB:O00519"}
{"id":"473e34b1-e2d2-4922-8427-96c2fbeccde6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:8099294d-6beb-40bc-9a00-be6d8d1f3077","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P28222"}
{"id":"f81c4db2-bf96-4d2f-8f83-7b7341e9e87c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:8754","sources":[{"id":"urn:uuid:aff2bc38-3a3c-4887-bcaa-3b74805440a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:Q13443"}
{"id":"f933ffac-da80-4a58-b9cd-79a5d4b8c17a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6440220","predicate":"biolink:affects","object":"NCBIGene:57121","sources":[{"id":"urn:uuid:bc579774-2d55-4c18-8dc0-7e8a2925380f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2911","original_object":"UniProtKB:Q9H1C0"}
{"id":"8529bcda-2774-43da-a3e0-81e9970975b8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:K5IZ54DF9G","predicate":"biolink:affects","object":"NCBIGene:3702","sources":[{"id":"urn:uuid:afeda3ce-a130-42f9-898c-da3176e8cbce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9285","original_object":"UniProtKB:Q08881"}
{"id":"e3a5a536-9e98-4df8-b48c-00a6d828a381","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8532","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:30ee4f32-2dac-4b93-a526-7a7527324cee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8532","original_object":"UniProtKB:P61073"}
{"id":"4ad3e896-2e07-46cd-ac11-4acaf71892f4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TJ1W0H78EJ","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:5bffa839-c351-4aba-89b9-696435d1534e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8721","original_object":"UniProtKB:P49798"}
{"id":"4271ad09-fe9a-4e1b-b9d7-ba075ee43f5a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31448","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:ed0e13fa-fa8e-4014-9ea9-15a7466fd3e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4167","original_object":"UniProtKB:P42262"}
{"id":"37339799-084a-4a2b-834e-fd29f3e94884","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2023","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:eb25d1b6-9d82-4ccd-a63d-dcc6395be56a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2023","original_object":"UniProtKB:O08858"}
{"id":"f34a1606-a151-480b-932a-885b620d3de1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145996540","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:7d5c4299-d2a6-4ceb-a74e-afc878cfed61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10702","original_object":"UniProtKB:P42336"}
{"id":"dbda7af3-fc6e-4f84-a547-af10194da872","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10279142","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:5e7dbaf6-71f2-4eb2-ae5c-be16c6970cad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1182","original_object":"UniProtKB:P30968"}
{"id":"bb39a969-7c62-46c6-b457-0f5eef80f691","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46213949","predicate":"biolink:affects","object":"NCBIGene:14745","sources":[{"id":"urn:uuid:d529ee85-35ef-445c-951b-75120fd83b5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6988","original_object":"UniProtKB:P61793"}
{"id":"6bfc131b-6263-423d-9fea-d2b2fcfb280b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65346","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:4041cc21-8264-4227-92d9-42e2c34a7d9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7449","original_object":"UniProtKB:P20309"}
{"id":"bc44fb3c-cb27-401e-86fc-b91e7aa9d62f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132749","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:1e393901-a165-4c16-98b7-e388935bf872","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1923","original_object":"UniProtKB:P34995"}
{"id":"11a0fbc3-3979-4a35-88f0-4b2d5273317a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:9da487e0-d84d-445f-8d92-927a3122cb8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P28223"}
{"id":"fcca6654-23a5-44e7-af1b-cf0b195c4f25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:99EAI85506","predicate":"biolink:affects","object":"NCBIGene:24239","sources":[{"id":"urn:uuid:f0bb256b-5976-4f9a-9ba9-deb123a925e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2517","original_object":"UniProtKB:P22002"}
{"id":"ba7c4c49-09c3-42e0-b22f-35e9556bef6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2356","predicate":"biolink:affects","object":"NCBIGene:57657","sources":[{"id":"urn:uuid:6045580c-47f4-477b-ad55-2e96890a9c80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2356","original_object":"UniProtKB:Q9P1Z3"}
{"id":"ab8433b1-7dc5-4168-89c2-f939bcb6cdde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:NU90V55F8I","predicate":"biolink:affects","object":"NCBIGene:3570","sources":[{"id":"urn:uuid:493834dd-b889-4871-936f-3c10380c2370","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:7999","original_object":"UniProtKB:P08887"}
{"id":"29482163-f242-43f0-bce8-67ce961a2ed7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166485054","predicate":"biolink:affects","object":"NCBIGene:11184","sources":[{"id":"urn:uuid:d68d15c2-de4c-4944-bded-90bc6b4a9395","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13722","original_object":"UniProtKB:Q92918"}
{"id":"6c5e88b7-cd62-4868-8370-2889ae8dbb0b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230523","predicate":"biolink:affects","object":"NCBIGene:2572","sources":[{"id":"urn:uuid:43a783f8-87b0-4af4-9787-9fab6dcee4da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5267","original_object":"UniProtKB:Q05329"}
{"id":"7093f4a6-2147-4bd1-9332-cd5c060d7bb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7862","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:edf941fc-d430-4e71-9e6f-3022ebaa8f40","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:124","original_object":"UniProtKB:P18825"}
{"id":"13fbe503-d18e-43ca-a64b-4c99a2586438","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P7Z08VK9XO","predicate":"biolink:affects","object":"NCBIGene:2159","sources":[{"id":"urn:uuid:371ccc89-d035-4d57-89c5-5b267c881e99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11364","original_object":"UniProtKB:P00742"}
{"id":"d9c93d09-70c6-4afa-85dd-be6fc0de7550","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8S5G34WY1","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:77bc4832-60ca-468d-a36e-be031be111d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11024","original_object":"UniProtKB:P21462"}
{"id":"0fc6519c-05ff-4ec0-ac6d-30f73e006603","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63633","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:02d8cf0a-bbd0-41e9-8e40-4781bf2eb794","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1177","original_object":"UniProtKB:P30968"}
{"id":"7fd59cd0-8275-4aa1-ba09-62f0133fef34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:877050b3-94aa-41d9-90f9-c9084edb3dd0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P28335"}
{"id":"0974e826-20e7-46c1-a478-5712e0dabfd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7738","predicate":"biolink:affects","object":"NCBIGene:24520","sources":[{"id":"urn:uuid:44020913-abba-45c6-a3b2-2d891fedd6f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:7738","original_object":"UniProtKB:P10499"}
{"id":"8c1efbb6-7862-491f-8c15-5fec39d8ac61","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118705601","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:2dc39204-c46d-412e-abba-206984be20c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1520","original_object":"UniProtKB:P25929"}
{"id":"2311bcfe-d077-4c5c-bc80-908d9a764fcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102216630","predicate":"biolink:affects","object":"NCBIGene:7223","sources":[{"id":"urn:uuid:fd4aad69-3c01-41a9-bd10-1fa06872b3d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10287","original_object":"UniProtKB:Q9UBN4"}
{"id":"6fb70849-743e-478f-a6dd-b35f3eceb07e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167664","predicate":"biolink:affects","object":"NCBIGene:5594","sources":[{"id":"urn:uuid:9cd85e34-c06b-4a6f-a98e-e6cd96a422f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9974","original_object":"UniProtKB:P28482"}
{"id":"ad6fb441-621c-4899-8619-8b081d93c2a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44185378","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:67fd13ec-9723-4db4-83f2-e3e2d42d0d56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3127","original_object":"UniProtKB:P37268"}
{"id":"15b82cbe-31bf-4aff-821e-43174c85efae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:4f40cbd1-dcee-4fab-9d8f-82ec8f2bb827","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P48169"}
{"id":"50e64264-3a5b-4151-b3ca-e6c76085a480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:75124305","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:8eba04e1-8112-44ea-97dd-9062e2842042","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7522","original_object":"UniProtKB:O60885"}
{"id":"b2f738bf-6aeb-4a23-93a4-94eb5c188db2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5777","predicate":"biolink:affects","object":"NCBIGene:719","sources":[{"id":"urn:uuid:3c453f39-322a-42a3-a83b-01d884199ff0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5777","original_object":"UniProtKB:Q16581"}
{"id":"9364b768-8e5d-4779-91fd-e202a6a12f8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138740335","predicate":"biolink:affects","object":"NCBIGene:23945","sources":[{"id":"urn:uuid:f04a60cb-5a23-4be3-b1ac-7527816f6b81","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12123","original_object":"UniProtKB:O35678"}
{"id":"d6648d38-2d4c-40a8-8349-1fa757aa9d22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6128","predicate":"biolink:affects","object":"NCBIGene:5743","sources":[{"id":"urn:uuid:65b4aa17-463e-4258-ac76-d43c16cccf25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4795","original_object":"UniProtKB:P35354"}
{"id":"06a83ffc-258f-422a-8dfa-80b2d062df9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44404987","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:b4f2abfc-038a-4637-8b80-ed7f52826b4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1699","original_object":"UniProtKB:O43614"}
{"id":"6068b999-9751-4628-98de-1ebd089f9951","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1512","predicate":"biolink:affects","object":"NCBIGene:4889","sources":[{"id":"urn:uuid:9f3e8599-f0c6-4659-ba44-b94a4263eb97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1512","original_object":"UniProtKB:Q15761"}
{"id":"a8cf0ee3-bf03-4901-a683-c780afdb3843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2041","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:066f547f-d7fd-4c29-80db-f4395a4d024c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2041","original_object":"UniProtKB:P32745"}
{"id":"3c3be140-dabd-4caa-9925-dd4842608981","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6121","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:a9ac1be5-f3de-4554-8966-264f84757c1a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4233","original_object":"UniProtKB:Q13224"}
{"id":"35a249a0-679e-495d-802a-4b4f1f24f4a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:6fad20d8-4850-4ec3-972c-36a2a79e0fc7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P32305"}
{"id":"c7e89a25-384e-449e-9a27-381ce11caf26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91801117","predicate":"biolink:affects","object":"NCBIGene:3416","sources":[{"id":"urn:uuid:314fe1ac-dada-4a8d-bad9-50d0b0e22a47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8597","original_object":"UniProtKB:P14735"}
{"id":"c9273f1a-ee1b-42d8-892d-d9b6f84006f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92555","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:b76a45cf-eb71-43f1-92b3-e937c23b56ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1562","original_object":"UniProtKB:Q63634"}
{"id":"dd930943-a3cb-42bf-8e56-3e55601fee6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817486","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:51abce40-b932-4fbb-a572-9cc4808338de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6123","original_object":"UniProtKB:Q62805"}
{"id":"d9104354-3056-4bbb-a592-c55a45da9aea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93472","predicate":"biolink:affects","object":"NCBIGene:5150","sources":[{"id":"urn:uuid:469ea4f7-8d8d-4039-b0e6-7ad3265f091d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5154","original_object":"UniProtKB:Q13946"}
{"id":"4e837f3f-5567-4bf2-8102-3fde04f233cc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143114","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:97773991-f46e-4ef4-848d-e8dcc2f8a548","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8945","original_object":"UniProtKB:P49336"}
{"id":"59a1401a-a241-4f36-be7a-b9926629f191","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80238","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:d6f72968-36c8-49f9-948b-0bf508758763","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:639","original_object":"UniProtKB:P46663"}
{"id":"7b726a0f-9b7a-48bb-9818-13f9f525a506","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167707","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:5fb2c717-c171-42ec-bbc6-c17802204720","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8912","original_object":"UniProtKB:P00533"}
{"id":"bcae2bae-c6ff-478b-ba1d-e217d2c50f54","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9386","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:91b5091a-6baa-409e-a2e3-2ec60f9ac6ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9386","original_object":"UniProtKB:P08069"}
{"id":"2eb53c42-6938-4177-8013-e87e07b410d5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64055","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:558d267a-fb32-4cbc-9fe9-cf7beb52ae26","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:109","original_object":"UniProtKB:P28222"}
{"id":"ebd1002a-1be9-4371-84eb-cbd9fb3d7749","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:05FZV98342","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:f4a22c7e-1b8c-4539-b3d6-db4f32c3b025","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7747","original_object":"UniProtKB:P11473"}
{"id":"c188d4a4-5405-4297-9b6a-58eaa2f01b90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5113G7FP34","predicate":"biolink:affects","object":"NCBIGene:58959","sources":[{"id":"urn:uuid:aa88206a-5901-4b08-9bc6-53937eec3df7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3496","original_object":"UniProtKB:P35353"}
{"id":"9ee3bb58-c219-46b4-8ba8-4deab04eb395","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N7Q9NLF11I","predicate":"biolink:affects","object":"NCBIGene:43740568","sources":[{"id":"urn:uuid:3ec278d4-8e4b-43fa-b9d6-67789eed9752","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:11331","original_object":"UniProtKB:P0DTC2"}
{"id":"19e1f9b3-fe09-45ba-9e08-a013b3f0abba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9890585","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:7774d513-7b9a-4386-a2ea-5eb3784aea22","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2657","original_object":"UniProtKB:Q07869"}
{"id":"402e4a6c-c709-4c40-97d8-bd4eee5a1ca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311225","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:47d2ec56-92ff-4329-aab7-854e77162d15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1918","original_object":"UniProtKB:P34995"}
{"id":"3ab44054-d3a7-4bc6-b5fb-035a7b5fa089","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:102167","predicate":"biolink:affects","object":"NCBIGene:1592","sources":[{"id":"urn:uuid:19e03ad0-a74f-4d5b-98eb-d6f48c5dd5b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11381","original_object":"UniProtKB:O43174"}
{"id":"ad1ee359-982f-4c09-b170-251d1bad81c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35420","predicate":"biolink:affects","object":"NCBIGene:4308","sources":[{"id":"urn:uuid:f6c7339b-f3c9-4488-a28c-c914cd05a315","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4290","original_object":"UniProtKB:Q7Z4N2"}
{"id":"40027ecb-c3ef-4978-a20d-e2625bb66c6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232878","predicate":"biolink:affects","object":"NCBIGene:7222","sources":[{"id":"urn:uuid:182dbe04-4425-423a-9d3c-742f43cadc44","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10278","original_object":"UniProtKB:Q13507"}
{"id":"8586cc4d-7644-41d1-93ad-0d223652bcf9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817468","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:a7dca7f2-a057-4a02-800b-7e8231769868","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4022","original_object":"UniProtKB:P49683"}
{"id":"96acd046-b7c5-4512-aaca-8436d6f2e92b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68453302","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:e4efcd93-86f4-4114-b140-289a124f4697","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12197","original_object":"UniProtKB:Q09472"}
{"id":"9910e51b-2140-4919-a82e-829de9f165ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9824507","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:3b557b44-5f40-429b-bc2e-6e2bc7b53223","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1920","original_object":"UniProtKB:P34995"}
{"id":"3975f085-ed89-4f60-b522-b6b635d7dbce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559100","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:aee8f79b-b434-49bb-8dae-49185bdd76ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:219","original_object":"UniProtKB:P41595"}
{"id":"0960dc62-2f02-40fd-b96c-8623ca2fba76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4162724","predicate":"biolink:affects","object":"NCBIGene:2931","sources":[{"id":"urn:uuid:347358aa-aa44-4d2b-a961-1badc8327ff7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7819","original_object":"UniProtKB:P49840"}
{"id":"82fc28b3-fb82-48c0-8d1f-43fa141bfd21","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135946","predicate":"biolink:affects","object":"NCBIGene:886","sources":[{"id":"urn:uuid:e1ed1d56-ad7f-4402-bfb1-8fc408ef7114","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:864","original_object":"UniProtKB:P32238"}
{"id":"8cccf5b6-2e24-485c-a57d-7d147ee090af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53321936","predicate":"biolink:affects","object":"NCBIGene:7442","sources":[{"id":"urn:uuid:55b8df58-ce1c-45a7-ad8e-a1da4e672862","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4076","original_object":"UniProtKB:Q8NER1"}
{"id":"dc9c07f8-6853-4dcb-85fb-5c34a52fbd55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:2521afa3-5ea0-47d0-a127-c60f3ad68b79","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:Q9BPV8"}
{"id":"f8b66f2a-7cee-4e5d-9b70-4e877f8dadab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44299731","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:4faff559-95fe-4421-8c73-d38422d00f3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:585","original_object":"UniProtKB:P50052"}
{"id":"f7e11ffe-e99d-4ceb-a4af-8e998d565921","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63634","predicate":"biolink:affects","object":"NCBIGene:771","sources":[{"id":"urn:uuid:2d28826d-17fd-4196-912c-727e72678bb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2894","original_object":"UniProtKB:O43570"}
{"id":"0755289e-1a6d-44e6-827c-92700ce64311","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60168163","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:89554ee0-8b69-4bc9-9b72-ed88e628449b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5735","original_object":"UniProtKB:Q8TDV5"}
{"id":"9c630e74-31ca-4298-8f56-e1ac0cd30cbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N9PH4O199D","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:3abc0cdb-e3db-4f4d-8e01-49321fcd9b67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8136","original_object":"UniProtKB:P52333"}
{"id":"7bbd0e4e-dc39-49f3-88c6-497d99a96c15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164561427","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:0617e8ff-0fa8-4fa5-a90f-01a80ff4f154","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13917","original_object":"UniProtKB:P03372"}
{"id":"ac0677b5-6b36-4b1a-a625-f6bb2ffa2684","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92885","predicate":"biolink:affects","object":"NCBIGene:5591","sources":[{"id":"urn:uuid:7c77ce1b-7eab-4f6e-aacb-92de632e8215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5961","original_object":"UniProtKB:P78527"}
{"id":"60e2970c-6e1a-4164-9392-13448a869612","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15650","predicate":"biolink:affects","object":"NCBIGene:574402","sources":[{"id":"urn:uuid:6c233c3c-4bbc-40b6-b6f3-ebc8d2f5b5ba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3352","original_object":"UniProtKB:Q6NS65"}
{"id":"53a18a62-040a-4eb9-bb21-f940f24e46f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:356afbdf-f332-496a-978e-38e5ac5b3c4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:O43526"}
{"id":"9a16a41c-e243-43b5-be5c-b5ad4143dae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34605","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:44153e32-c2c6-4e99-881d-09ecadf24bd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4165","original_object":"UniProtKB:P42262"}
{"id":"b8fd9bc1-9871-4883-a711-8cda0489aae2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11597537","predicate":"biolink:affects","object":"NCBIGene:5602","sources":[{"id":"urn:uuid:a56e2113-e1d4-45dd-a776-0f3e033a66e1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9836","original_object":"UniProtKB:P53779"}
{"id":"7d8bd444-41bd-4ed9-a3b4-8fd829a153cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:9e68d610-875f-4404-8f73-30e37693d171","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P30939"}
{"id":"e7e3a92f-0c2f-4601-9ea0-9bfa79cd72c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93201","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:88c22618-5c5c-4bbf-b3ce-9014efa254c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4347","original_object":"UniProtKB:P47869"}
{"id":"d114b9fd-adcf-45cf-b982-a52df7772426","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:111176","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:7a1878cb-82bc-4f36-a1a9-43b20bd34e87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3296","original_object":"UniProtKB:P35462"}
{"id":"d70720ef-228d-4c96-837c-30020cb779f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2264","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:57bdc1c2-4929-44a4-99c9-cf1713f8f36a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2264","original_object":"UniProtKB:P41587"}
{"id":"76ceda32-6085-491c-bfc9-0efc491ee7e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45980","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:a6ca9a3d-fb04-4aed-9e7f-146f3f892047","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6687","original_object":"UniProtKB:P22303"}
{"id":"9f4305e8-bd4e-4351-bb7e-7a42a027c756","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92814","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:0a9ef71b-0a34-453a-bd44-84b7224166b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3283","original_object":"UniProtKB:P30542"}
{"id":"f03a5559-bd16-457e-99e1-ae25a2df4569","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134813646","predicate":"biolink:affects","object":"NCBIGene:26090","sources":[{"id":"urn:uuid:d9f4df6b-8993-4a65-86ba-7129b6d1800a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10250","original_object":"UniProtKB:Q8N2K0"}
{"id":"d797cf7b-c33d-4709-b919-f164e46cfcf5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:68902536","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:c3e49c88-aef8-442f-b1f1-31024e13b75f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13511","original_object":"UniProtKB:P21554"}
{"id":"0734921b-9766-4ae3-be02-098b59494b7f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2193","predicate":"biolink:affects","object":"NCBIGene:552","sources":[{"id":"urn:uuid:af55de0e-57f3-445d-9412-6074205d7051","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2193","original_object":"UniProtKB:P37288"}
{"id":"701fdc42-d310-4dce-9c9a-8b57c21957de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:123188","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:2d6ddaeb-c0e6-4ff8-becd-afbe182f446f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10288","original_object":"UniProtKB:Q9UL62"}
{"id":"beaeb76b-3a5a-4ec6-aacc-6edcab2418fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93751","predicate":"biolink:affects","object":"NCBIGene:5058","sources":[{"id":"urn:uuid:cbf25011-ebc0-4260-ab33-35577c750406","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8937","original_object":"UniProtKB:Q13153"}
{"id":"626bcf82-f0c5-4d79-8ed8-4a963fe642a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80308","predicate":"biolink:affects","object":"NCBIGene:117194","sources":[{"id":"urn:uuid:8c91373d-0d0f-48a6-827d-a7f415acc59b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2098","original_object":"UniProtKB:Q96LB1"}
{"id":"5d5a9ddb-1f00-4e74-b950-12535888d566","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:08WG8S0L8D","predicate":"biolink:affects","object":"NCBIGene:1576","sources":[{"id":"urn:uuid:4474b341-d923-4718-bdfa-10205f7147d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8913","original_object":"UniProtKB:P08684"}
{"id":"d07985f0-4a91-467b-b145-daaa0bebf479","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44331779","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:401b45ae-57e3-437d-ba8c-f5e7080a1083","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2977","original_object":"UniProtKB:P51639"}
{"id":"fa130d5a-5351-487f-8d47-ee23dd3bb1f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9852373","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:d4a9f3bd-190d-4d66-b02c-6564bcb227c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2120","original_object":"UniProtKB:P21452"}
{"id":"252ce2a9-8e55-4103-af31-4cd35de0c1c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231410","predicate":"biolink:affects","object":"NCBIGene:84444","sources":[{"id":"urn:uuid:fe62b5bd-a552-4384-abf0-134a38da4732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9205","original_object":"UniProtKB:Q8TEK3"}
{"id":"fae1eb25-51c4-47b5-ab01-bb8b0e5cd199","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13304","predicate":"biolink:affects","object":"NCBIGene:4070","sources":[{"id":"urn:uuid:f88eeeea-4b9b-415a-b0cc-eab15f2981a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13304","original_object":"UniProtKB:P09758"}
{"id":"ee2a1a61-79c5-4d30-b05c-31485d87d0d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9891167","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:ccc0ad0a-8329-4689-858b-b8adf3f6a7b2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:491","original_object":"UniProtKB:P23944"}
{"id":"23ed63fa-efe8-44ea-b427-956ea2c8645c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:171113","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:bc6adc20-d00d-48ff-a5a4-fc3a7b209070","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2180","original_object":"UniProtKB:P47901"}
{"id":"3df21726-5d28-467a-a9e1-99fe011e11d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71954","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:7f131a97-1a97-4a3d-b19c-582ff00bd0c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7878","original_object":"UniProtKB:P42336"}
{"id":"cb91aa7b-6e84-42ab-98b4-e23f177be40c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53320668","predicate":"biolink:affects","object":"NCBIGene:292661","sources":[{"id":"urn:uuid:95c8779a-7a77-40c9-b38c-d8455ecf7c85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1966","original_object":"UniProtKB:P43253"}
{"id":"3dd6c4ca-7b77-4417-ae68-99163234e7ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9851134","predicate":"biolink:affects","object":"NCBIGene:838","sources":[{"id":"urn:uuid:bae946a5-01c2-4a94-a271-eb3c682c4417","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8654","original_object":"UniProtKB:P51878"}
{"id":"75fc7bef-9dc9-478a-b17b-8bb40e19408b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24883277","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:a2d6b1dc-201b-498d-8c8f-539e8939ec35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9538","original_object":"UniProtKB:P56373"}
{"id":"f300653f-3b3c-4860-b4da-5cea491ed2a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5962","predicate":"biolink:affects","object":"NCBIGene:2260","sources":[{"id":"urn:uuid:4466a9b7-c4b0-4b77-a7ad-b0056a0e29aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5962","original_object":"UniProtKB:P11362"}
{"id":"acaa92a5-c2b8-482a-938a-6a9e138f3e7d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6220","predicate":"biolink:affects","object":"NCBIGene:24415","sources":[{"id":"urn:uuid:0fa85d0f-3345-4a3d-a69a-04e1c3cbfe52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6220","original_object":"UniProtKB:P31421"}
{"id":"c0c66824-e76e-4b1f-be3d-1208a9c529e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0QRY57BJCX","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:4e6c89d7-367a-48a7-8427-c042e9c1b52f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3168","original_object":"UniProtKB:P14324"}
{"id":"5fb1a9c0-c0bc-49a8-8427-948815b12150","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104133","predicate":"biolink:affects","object":"NCBIGene:1644","sources":[{"id":"urn:uuid:4028eed4-90fb-4bed-8272-b4c43ef090d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5116","original_object":"UniProtKB:P20711"}
{"id":"6a1fc6dd-5f9e-41af-804b-d4785eb8cae1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17351","predicate":"biolink:affects","object":"NCBIGene:3745","sources":[{"id":"urn:uuid:1334c784-86bb-4059-8c84-17476a9e27f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1052","original_object":"UniProtKB:Q14721"}
{"id":"2c6255cd-06ae-4226-9df7-17993b45f63b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:196096","predicate":"biolink:affects","object":"NCBIGene:2566","sources":[{"id":"urn:uuid:69ab8103-9b63-4c77-8349-5efa2019add7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4320","original_object":"UniProtKB:P18507"}
{"id":"afaad83a-289b-4220-8858-39167ef450c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90199447","predicate":"biolink:affects","object":"NCBIGene:545","sources":[{"id":"urn:uuid:22d7bdff-3085-47af-9cca-8951e5003020","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12082","original_object":"UniProtKB:Q13535"}
{"id":"b2640e87-e5f0-475e-be8b-d9d064be9be3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135948915","predicate":"biolink:affects","object":"NCBIGene:846","sources":[{"id":"urn:uuid:8f89618d-da93-4398-a626-3f7d2fd5cf1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10590","original_object":"UniProtKB:P41180"}
{"id":"fdc192dd-945f-4f95-9919-cd50553b9854","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:80AXY59IT2","predicate":"biolink:affects","object":"NCBIGene:4312","sources":[{"id":"urn:uuid:ac0c75af-c072-41a8-86d3-36215f42c4bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8846","original_object":"UniProtKB:P03956"}
{"id":"8311e858-a7be-44fe-9da0-c1547a667cd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1512","predicate":"biolink:affects","object":"NCBIGene:29471","sources":[{"id":"urn:uuid:a70c8875-bfdc-4c26-a97f-40df0b96a15c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1512","original_object":"UniProtKB:Q63447"}
{"id":"7fbc52b6-caee-4d3f-86ff-32f7b45d386b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77898","predicate":"biolink:affects","object":"NCBIGene:1582","sources":[{"id":"urn:uuid:93fc00fd-50cb-470d-8907-7156caaf5aff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13859","original_object":"UniProtKB:Q9UNU6"}
{"id":"8518f31c-a43c-4417-8b3b-2d379792d85a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11692123","predicate":"biolink:affects","object":"NCBIGene:2864","sources":[{"id":"urn:uuid:b18fa393-bcd1-427d-a066-9df9cf33b939","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1057","original_object":"UniProtKB:O14842"}
{"id":"99b78cbe-0670-4c31-99a5-2680f171e0ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1526","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:746297a7-c609-4aee-a6c0-6232511af76d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1526","original_object":"UniProtKB:P21555"}
{"id":"9a831e26-84b4-461e-8f15-27374c54d55a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3899","predicate":"biolink:affects","object":"NCBIGene:14428","sources":[{"id":"urn:uuid:e8f0f075-36ce-4d2f-9bca-b5bf30918568","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3899","original_object":"UniProtKB:O88854"}
{"id":"adf9ee4d-a2f5-40e1-81b2-7f45fb162aa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9654","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c6927e5e-4085-488d-a896-89a21fba507b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:213","original_object":"UniProtKB:P28335"}
{"id":"10996baa-37b6-428e-97f9-6c4d6e3f10f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145994","predicate":"biolink:affects","object":"UniProtKB:P0DTD1","sources":[{"id":"urn:uuid:1a4d758d-bb13-4018-8aa5-0faac059b9a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10715","original_object":"UniProtKB:P0DTD1"}
{"id":"980f3e17-3e47-4d4b-a843-e1aa6695bcc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:5979","sources":[{"id":"urn:uuid:2fc2cf98-8722-48c9-baa7-8e639329f450","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P07949"}
{"id":"c1a3f07c-9536-44d2-9191-90d1f5495488","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:547KGL06IP","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:7c55d8ea-38d9-458e-a2ff-2c9f4c9b1278","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13550","original_object":"UniProtKB:P14842"}
{"id":"66443837-ef36-4f45-8d71-f6c79c5c2f9d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:141754136","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:1f854107-fd26-4ec6-9252-f9d06c19d436","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11204","original_object":"UniProtKB:P42336"}
{"id":"99b39242-48ac-4605-acbf-77474560b632","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3363","sources":[{"id":"urn:uuid:afe7738f-7c7b-44e7-838a-e28f1633a186","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P34969"}
{"id":"e1b9d253-e671-4b12-bce9-5df5da357528","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134764","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:c852c122-f3fa-44c6-b612-19996c5a07c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:299","original_object":"UniProtKB:P20309"}
{"id":"c82a6a52-9fb7-4685-896e-100199d03a94","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71245042","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:915fec6d-1257-4ebd-9b44-2749ee0092c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8897","original_object":"UniProtKB:P03372"}
{"id":"ae7d0180-43c3-4ce4-b814-df97e0834cb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:4a957aee-0226-4858-982c-956cd2548993","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:708","original_object":"UniProtKB:O15399"}
{"id":"dce84fa0-1600-4776-827d-22a78bbab143","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135489224","predicate":"biolink:affects","object":"NCBIGene:8654","sources":[{"id":"urn:uuid:598e8cff-5407-4067-8e42-09b269a6c5f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12099","original_object":"UniProtKB:O76074"}
{"id":"67cb9b39-ee1b-40a6-a3a9-3dd066753dc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13529","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:940de2c3-30cb-4c90-b16e-25eb468f0a61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13529","original_object":"UniProtKB:P18031"}
{"id":"1b4dc447-8e04-46c1-9076-e45ae708b73a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9847835","predicate":"biolink:affects","object":"NCBIGene:840","sources":[{"id":"urn:uuid:297658d4-c0d6-4bf2-99ea-88fd64ab4d0b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6515","original_object":"UniProtKB:P55210"}
{"id":"33ca7b65-0cc9-4478-9dbd-dbd227dfd227","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45293","predicate":"biolink:affects","object":"NCBIGene:32","sources":[{"id":"urn:uuid:1fef2940-da33-402d-b94e-00c567ce73a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12243","original_object":"UniProtKB:O00763"}
{"id":"b2ebe9bf-c897-4528-ab6d-ada2f471560e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:87103","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:9c367bd6-02ad-447d-8698-ad776e6f8290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5992","original_object":"UniProtKB:O60674"}
{"id":"169abb2c-384d-4d32-926d-33670c4ba9a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10055","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:f23fa1e5-ab9e-4fcc-9206-149b606097b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:538","original_object":"UniProtKB:P08588"}
{"id":"1e0e06d6-7d55-4458-86f5-288c938467a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137553167","predicate":"biolink:affects","object":"NCBIGene:56670","sources":[{"id":"urn:uuid:abb808de-255a-4c3c-9fe9-4c58a1638a91","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10296","original_object":"UniProtKB:Q9BXA5"}
{"id":"e394f67f-9520-4e3e-aaf6-f118d7958ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8214","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:7bf28bab-5c8b-4bcb-a7f8-1210019f4493","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:91","original_object":"UniProtKB:P08908"}
{"id":"e7cfb4b7-9a69-420b-9bab-8b603566400b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132914","predicate":"biolink:affects","object":"NCBIGene:14715","sources":[{"id":"urn:uuid:1bceac84-3e11-45e0-bc5b-7075dd9a3645","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1162","original_object":"UniProtKB:Q01776"}
{"id":"57cb936f-4def-4eff-a39e-2d8c5c132926","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4546504","predicate":"biolink:affects","object":"NCBIGene:1196","sources":[{"id":"urn:uuid:edc2eff2-cbfa-4540-a00c-df4e9c67faea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10371","original_object":"UniProtKB:P49760"}
{"id":"44425e75-16a7-4ada-bcf0-5314a6b9c614","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44352887","predicate":"biolink:affects","object":"NCBIGene:29580","sources":[{"id":"urn:uuid:1d32c9fe-4682-45ef-acaa-0a2ae561658b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3086","original_object":"UniProtKB:Q02769"}
{"id":"08ed1197-13d9-4f56-bce6-ce0db0d7eaa7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4612B80545","predicate":"biolink:affects","object":"NCBIGene:25825","sources":[{"id":"urn:uuid:7ce8deb4-e9ab-45af-8c8c-95857cd92f06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12747","original_object":"UniProtKB:Q9Y5Z0"}
{"id":"42376a3e-a173-46a2-9b86-f3ef7921aaea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7872","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:6f55d773-c8ad-419d-b785-179e694e52bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2174","original_object":"UniProtKB:P30518"}
{"id":"c3c05f00-a30b-4e56-9206-ee8bb2aa5411","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3766","predicate":"biolink:affects","object":"NCBIGene:3361","sources":[{"id":"urn:uuid:23dbe5dc-d142-4cce-bb8c-0cd562b57e0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:38","original_object":"UniProtKB:P47898"}
{"id":"1533163a-8414-430e-8cbc-edae1a1541b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71655433","predicate":"biolink:affects","object":"NCBIGene:5028","sources":[{"id":"urn:uuid:5971e5d7-5d4e-426f-990f-fa07edc0a643","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5901","original_object":"UniProtKB:P47900"}
{"id":"657a1282-4e26-423b-acb9-2515c25e6c50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:49847690","predicate":"biolink:affects","object":"NCBIGene:329","sources":[{"id":"urn:uuid:52e10635-1e84-4e77-921d-2c2a54c8f729","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7710","original_object":"UniProtKB:Q13490"}
{"id":"8ee2096f-775c-4455-845c-9324dae66729","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9571","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:20fce21b-0a1a-48e9-81e5-1695387f7b76","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:212","original_object":"UniProtKB:P28223"}
{"id":"c83e9345-5d61-4a44-a20d-4cf1edded1fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:SRV0JCF9LI","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:3d4e3836-5976-411c-b0b4-976924585a3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5685","original_object":"UniProtKB:P04629"}
{"id":"bc227435-839c-4263-8802-1329f7d0a5be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:81752","sources":[{"id":"urn:uuid:f90d523f-76e7-44aa-857c-63ab6389104d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:Q62928"}
{"id":"1a082553-5cb7-445f-a7ad-5b96b793ad3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10683","predicate":"biolink:affects","object":"NCBIGene:799","sources":[{"id":"urn:uuid:f7e37184-d2a5-4f31-b705-3e96ca29ca2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10683","original_object":"UniProtKB:P30988"}
{"id":"215e103a-46ea-4155-8d1a-59c5442d9e9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31515","predicate":"biolink:affects","object":"NCBIGene:29238","sources":[{"id":"urn:uuid:7be47c80-c8b6-4e83-8c90-9edc0652d60d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:965","original_object":"UniProtKB:P19020"}
{"id":"c846ed48-a205-4629-9563-fd6fb0bd6945","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:WZ9TJ0L9Y8","predicate":"biolink:affects","object":"NCBIGene:6790","sources":[{"id":"urn:uuid:e9ce6b31-06b1-4cd7-9023-04a47cdd3768","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11887","original_object":"UniProtKB:O14965"}
{"id":"0dda54d5-c7d6-46a4-9533-5ebeceeab8a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44445","predicate":"biolink:affects","object":"NCBIGene:664630","sources":[{"id":"urn:uuid:f7894b91-8fbd-4dbb-9c2c-5c1170cad8ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7401","original_object":"UniProtKB:Q2A865"}
{"id":"b40dfe02-d19a-409a-920c-0ebf2cf2acd7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311023","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:565c8506-dc7e-4d95-84d1-77fde7dfee94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1485","original_object":"UniProtKB:P21555"}
{"id":"1f444da8-0f7a-47bf-ab0d-64918d1d04d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77317","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:a47542d6-5098-4640-902d-a5c482c723de","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2763","original_object":"UniProtKB:O75469"}
{"id":"0a6e200f-fb58-4fb6-aef6-a16d7ec9d9d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80131","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:87a7728a-b09f-4f0e-9f04-57dc48fc87d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:605","original_object":"UniProtKB:P35414"}
{"id":"54b32c86-663c-4611-b7e1-8f6a432f2e93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9442","predicate":"biolink:affects","object":"NCBIGene:84109","sources":[{"id":"urn:uuid:25aef055-4f9a-4347-8207-f22a8e969cf6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9442","original_object":"UniProtKB:Q96P65"}
{"id":"a69f480d-f2a9-4c91-8e43-a86ecda3bc96","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AF75XOF6W3","predicate":"biolink:affects","object":"NCBIGene:3902","sources":[{"id":"urn:uuid:979c3922-352a-4829-b8a1-2754b561d0fe","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9536","original_object":"UniProtKB:P18627"}
{"id":"32d76e28-c88a-4e4b-a86c-6c537bc2c3e0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:195521","predicate":"biolink:affects","object":"NCBIGene:102414","sources":[{"id":"urn:uuid:cf60ed4f-8e6c-4482-9abb-189c3e746a3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8167","original_object":"UniProtKB:O35492"}
{"id":"bec70f1b-2f60-4b05-abc2-cd05f9e428c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28600","predicate":"biolink:affects","object":"NCBIGene:4598","sources":[{"id":"urn:uuid:b3b2a7a9-6b3c-42ed-8c1a-e81dfdc662b3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3215","original_object":"UniProtKB:Q03426"}
{"id":"c09f2172-9e13-4b34-ab3c-4ad05a3f9e01","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0E3D72URPD","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:e2befd69-9ccc-45bf-b58b-f9e7403301d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8996","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"527a2ab3-1733-4ae1-a638-f35a14640513","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1527","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:ab62b7fb-f137-42f2-9839-23e30843356c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1527","original_object":"UniProtKB:P25929"}
{"id":"09a711e0-6bf2-4ab9-a99b-2fea11ce9990","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30769","predicate":"biolink:affects","object":"NCBIGene:9033","sources":[{"id":"urn:uuid:e394f479-d018-43e0-b593-55249673168b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2478","original_object":"UniProtKB:Q9P0L9"}
{"id":"6e135258-e317-4090-8579-e207407cd283","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71611998","predicate":"biolink:affects","object":"NCBIGene:5144","sources":[{"id":"urn:uuid:bc5169d4-902a-4a19-ae9b-b3da092b22eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12725","original_object":"UniProtKB:Q08499"}
{"id":"432c9841-0e6a-4833-bf92-2f068c276631","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10742947","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:c24f070d-570d-4a27-97d3-2b3a5ec86cc0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:886","original_object":"UniProtKB:P30551"}
{"id":"2aa4c8dd-4046-4598-9759-e31ce45bd21d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311229","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:7a4b9ef7-0ece-4cc9-820d-d980587a48e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1931","original_object":"UniProtKB:P30557"}
{"id":"ae43c741-1f2b-4df0-a0d8-a5ba1ff49d8a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13113","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:0845213a-aada-4927-a6d5-74c2655b0932","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13113","original_object":"UniProtKB:O15379"}
{"id":"c58bb710-7266-4fe9-b0f0-7b45ff709501","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:19956992","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:b3ac1d55-a710-4d8f-95a2-944b50026bcd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3065","original_object":"UniProtKB:P37268"}
{"id":"63390e9a-1771-4747-8ba1-7a2d4e1a8802","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34946","predicate":"biolink:affects","object":"NCBIGene:63843","sources":[{"id":"urn:uuid:1d2c58d2-49e0-4ce7-91f9-857f17ad012d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1739","original_object":"UniProtKB:O35811"}
{"id":"6ff7001d-f03b-484a-a7f4-ddb2fc6fe3fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10124","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:2cd9535f-926b-464a-9234-db9aed1f6189","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:60","original_object":"UniProtKB:P28221"}
{"id":"f730a170-75d3-4f5f-9eaf-8f8ff7c4990f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:107660","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:43ecff54-aacb-489d-b01c-c62ae90e223a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2361","original_object":"UniProtKB:O15399"}
{"id":"2b553e00-567f-4941-b83f-514465502691","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31905","predicate":"biolink:affects","object":"NCBIGene:16523","sources":[{"id":"urn:uuid:38758f0a-7ced-4056-b8d2-a31c313448c4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2411","original_object":"UniProtKB:P97794"}
{"id":"c905d31f-7249-4c95-80ae-7c908e26f44b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8530","predicate":"biolink:affects","object":"NCBIGene:7852","sources":[{"id":"urn:uuid:d3d87d02-7265-47b8-850a-422a2c7e2271","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8530","original_object":"UniProtKB:P61073"}
{"id":"c51b2abc-ed54-4aac-b5f1-c7e8fbf7f7ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:58298316","predicate":"biolink:affects","object":"NCBIGene:2475","sources":[{"id":"urn:uuid:a9973bc2-830d-4b78-bfe6-4ca28eca6cca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8914","original_object":"UniProtKB:P42345"}
{"id":"e6ab08ee-634d-4524-ba69-c9e845487eae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:78332","predicate":"biolink:affects","object":"NCBIGene:8767","sources":[{"id":"urn:uuid:1fc7ce22-41c9-4988-b2eb-68feb3c0c473","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6042","original_object":"UniProtKB:O43353"}
{"id":"bde9d5ad-b50c-48bc-9478-42ac96b56fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131358","predicate":"biolink:affects","object":"NCBIGene:11541","sources":[{"id":"urn:uuid:3bbd7b20-7a6e-4392-895d-983756d96e4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3289","original_object":"UniProtKB:Q60614"}
{"id":"15f8e2cc-3b72-43b9-b671-6bc7bb3272c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92360","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:3c6f29f7-708b-4ad6-8699-085457b4f034","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:165","original_object":"UniProtKB:P30994"}
{"id":"e885288e-4d8f-46ca-9c08-65de80e16df2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J8AY0Z4CBP","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:b33acd11-a9ad-41e1-bdb5-dc6889d9c132","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8189","original_object":"UniProtKB:P04629"}
{"id":"efb645f0-474e-40c2-9130-fe208fd8874d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21202952","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:9a6b654f-3049-4d10-a926-b7d4437d258e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4208","original_object":"UniProtKB:O15399"}
{"id":"542c7571-d587-45c6-bae4-10981daa1cac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132233067","predicate":"biolink:affects","object":"NCBIGene:1786","sources":[{"id":"urn:uuid:dc28dd82-07c9-4e4d-93f8-35648bad2f27","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11750","original_object":"UniProtKB:P26358"}
{"id":"85ef52e1-9c16-4d82-af72-260f76e9bfd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:10188","sources":[{"id":"urn:uuid:3ff76ca6-4637-4396-8ca5-f94b543dc28d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q07912"}
{"id":"5bf3a3e9-a3b7-4b87-85cf-d829c596241d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CZ3T9T146K","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:a1373f07-966b-4229-95c4-d711372705a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2132","original_object":"UniProtKB:P21452"}
{"id":"f6f07de4-7cf7-4585-8753-237f9fa13edd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7640","predicate":"biolink:affects","object":"NCBIGene:3766","sources":[{"id":"urn:uuid:d318e18b-77d8-4b1f-9734-995fa8b812af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2404","original_object":"UniProtKB:P78508"}
{"id":"f5a0f1bc-931b-460a-bfdb-c196f05dfa22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:138236","predicate":"biolink:affects","object":"NCBIGene:680","sources":[{"id":"urn:uuid:c8fd71cf-8fd6-45b6-915d-3a539799f0b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13088","original_object":"UniProtKB:P32247"}
{"id":"d5ad32ce-11f7-4d97-b906-a99405761fd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:HB4QD9GL6F","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:2afeb905-ee29-441d-98c2-b9a9887c5f1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1607","original_object":"UniProtKB:P32300"}
{"id":"6f237bb3-3c99-4fd9-a39b-3df37953eca9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168868881","predicate":"biolink:affects","object":"NCBIGene:64115","sources":[{"id":"urn:uuid:2ff7c7ec-9264-4bcc-a4be-4eaea1fe7e6b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13680","original_object":"UniProtKB:Q9H7M9"}
{"id":"bb43351c-65c2-485a-89aa-c31169dda2f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34316","predicate":"biolink:affects","object":"NCBIGene:5024","sources":[{"id":"urn:uuid:d75f7db5-129a-4481-b416-43f310d2a5a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1757","original_object":"UniProtKB:P56373"}
{"id":"5b2d9742-fc79-4623-9087-e7aa9d671afc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27882","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:e488e51a-631e-4d94-aba0-3249c6a85c48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2367","original_object":"UniProtKB:P59540"}
{"id":"a21c5de3-6f7f-44c9-afb1-4c7f44961be6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311503","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:4b94ea33-9360-4254-bd88-dea03a94e008","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1889","original_object":"UniProtKB:Q13258"}
{"id":"47b8af34-499b-4e16-86e6-bb3ad5359edb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W1B375O5M2","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:de786dee-de06-4333-a309-d30354192578","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7881","original_object":"UniProtKB:P35968"}
{"id":"bebc23ee-2ca3-4edb-b158-2c912036884c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321153","predicate":"biolink:affects","object":"NCBIGene:7403","sources":[{"id":"urn:uuid:bc220acf-d7da-4fc0-8993-5c5712226ff4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10141","original_object":"UniProtKB:O15550"}
{"id":"cc02cab6-9e4b-4010-8c00-9bcf706c9fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135401973","predicate":"biolink:affects","object":"NCBIGene:338442","sources":[{"id":"urn:uuid:00ede073-35d9-4a1a-8b59-9b44bdcbf44f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5792","original_object":"UniProtKB:Q8TDS4"}
{"id":"3fb954e5-da0f-4e3f-b52b-692c0215be31","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:137236","predicate":"biolink:affects","object":"NCBIGene:4317","sources":[{"id":"urn:uuid:581e5e9e-529c-43ab-b670-4f6127cff0fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7409","original_object":"UniProtKB:P22894"}
{"id":"4bdb2cc1-d5d1-4474-9c3e-8b57323e065b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11916","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:bfbab1ee-6975-4b51-942e-60ecfe2500bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11916","original_object":"UniProtKB:Q8TDU9"}
{"id":"d393b9fc-c05f-4754-8606-e9f2ab472a14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5638","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:f268a4d0-6bee-4dde-94f9-c4e0985004bc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5638","original_object":"UniProtKB:P30874"}
{"id":"55f62546-f73e-4579-ba50-92bb1485bc04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:383414","predicate":"biolink:affects","object":"NCBIGene:54305","sources":[{"id":"urn:uuid:27adfb5d-7de5-4135-b9f6-6bddb82ef6bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2055","original_object":"UniProtKB:P30680"}
{"id":"0a756ddd-1949-4dd7-8d44-bf737587f7d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135704","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:37268838-e3bc-4c15-a7b7-f032e5eb456b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6441","original_object":"UniProtKB:P08246"}
{"id":"12d305d7-2d46-44b7-b312-ff7e3df09123","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156861524","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:c1d5f251-3800-49a6-bde3-ec453ee29aeb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13717","original_object":"UniProtKB:P21554"}
{"id":"a0b5dd6b-f3bc-448e-b3aa-5e1eb9699c3e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7760","predicate":"biolink:affects","object":"NCBIGene:9312","sources":[{"id":"urn:uuid:0e7ce52c-1af8-407f-9740-4bbd4bbfa886","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7760","original_object":"UniProtKB:Q92953"}
{"id":"3f9bdf65-5c17-4d7e-97fe-120d769f32a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Q77EAZ9TG9","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:fdf12c3c-886b-43d5-ba05-1964ce26405b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8434","original_object":"UniProtKB:P08908"}
{"id":"1640d2a9-07ff-4e16-a700-b66dc2652f97","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LXZ2G00X0W","predicate":"biolink:affects","object":"NCBIGene:53949","sources":[{"id":"urn:uuid:5a348501-6195-4009-ae06-d56ed7ef4237","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:310","original_object":"UniProtKB:P08911"}
{"id":"9bbf9628-5b20-44c2-92e6-f54b1d58a1bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92732","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:c63568ef-c289-47ab-8dc2-ec9cb58199af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8245","original_object":"UniProtKB:P35968"}
{"id":"98c83446-1bc8-4294-b317-81eb85f1825f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126970685","predicate":"biolink:affects","object":"NCBIGene:29110","sources":[{"id":"urn:uuid:d6fc7058-51ed-4363-a1d2-2a016a74641f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9579","original_object":"UniProtKB:Q9UHD2"}
{"id":"1b091256-b964-4515-bcd2-2fcaebae67c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699463","predicate":"biolink:affects","object":"NCBIGene:55869","sources":[{"id":"urn:uuid:837f52fb-a4d6-4a7f-ac23-8f18c317a002","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11220","original_object":"UniProtKB:Q9BY41"}
{"id":"d91aca85-4563-4533-b6bf-5f3913c1c735","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5AUY4Y2UPU","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:64ca351c-69be-4883-aec8-f65a0fdd088d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6577","original_object":"UniProtKB:Q9Y2T6"}
{"id":"d1dc8a54-4326-451a-be96-70a9c4240ed0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:66919","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:c8428cc6-055d-4daa-9318-999aea7bf3ce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5688","original_object":"UniProtKB:O60674"}
{"id":"35b3bbaf-dcff-43a1-bb8e-754d9c252270","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9860294","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:64f91c6f-781e-484a-b1dc-31ef1e483010","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5613","original_object":"UniProtKB:P30542"}
{"id":"09423b3b-0f35-4e3e-8a2e-12a68398f742","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10025114","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:88dd44a1-941f-41a7-b0e0-f7c66c323507","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4079","original_object":"UniProtKB:Q12879"}
{"id":"2909c7f0-11a2-4805-ad9f-c4493d5e2461","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:104162","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:8f3f0b33-9b4c-4080-a2b4-c5db5b970415","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10104","original_object":"UniProtKB:P08172"}
{"id":"4eb94b45-1e7b-4b63-987e-36dbfbf52957","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:176958","predicate":"biolink:affects","object":"NCBIGene:18386","sources":[{"id":"urn:uuid:8879e9af-7534-4eba-91a0-57e9e6bce641","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1609","original_object":"UniProtKB:P32300"}
{"id":"3848b235-ee91-4e4d-b82b-d7b8d80e0419","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146276619","predicate":"biolink:affects","object":"NCBIGene:4907","sources":[{"id":"urn:uuid:1146516f-956e-482f-9310-bed67d4c2692","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12355","original_object":"UniProtKB:P21589"}
{"id":"d35c17f5-7ba2-4f3e-8db3-6f056a359697","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53236401","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:2ac0d253-6ccb-481b-8212-b1af97211d31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10700","original_object":"UniProtKB:P43681"}
{"id":"c2b9ec23-252b-4638-ae8e-7a2399991f41","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2035","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:60237ccf-47de-482d-ab86-2c56d02680a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2035","original_object":"UniProtKB:P30874"}
{"id":"b2d51615-cbbd-49da-ada2-1979eaa8cbc9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17659","predicate":"biolink:affects","object":"NCBIGene:171108","sources":[{"id":"urn:uuid:bfcd1fd9-be25-456f-9e87-2efcabdb2c2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1749","original_object":"UniProtKB:O35881"}
{"id":"1f08700e-496c-493d-830d-965f984706cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50922685","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:25bd5556-b839-498c-b121-d943accaef43","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9294","original_object":"UniProtKB:P41145"}
{"id":"63b2cade-6a41-4cf6-a9b7-246f885b3a10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56646418","predicate":"biolink:affects","object":"NCBIGene:9641","sources":[{"id":"urn:uuid:91d985da-d5bb-46a2-9021-efff54956afa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9578","original_object":"UniProtKB:Q14164"}
{"id":"34a1d6bc-4bf1-4cfb-b7b1-0fcf57b59af8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167653","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:ccff176d-b794-47fc-9192-1d9a1887049b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7706","original_object":"UniProtKB:Q9UM73"}
{"id":"e8cf7c57-b30a-49a8-8acc-17e36a8e0233","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93613","predicate":"biolink:affects","object":"NCBIGene:57657","sources":[{"id":"urn:uuid:1de1ca0a-63ea-48f5-aea4-9cc72553ef08","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2358","original_object":"UniProtKB:Q9P1Z3"}
{"id":"7489e97f-0295-47f7-9bd2-a10cfa8e0a88","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134611888","predicate":"biolink:affects","object":"NCBIGene:57113","sources":[{"id":"urn:uuid:31e35109-67ee-4ff5-a325-a95f847b87d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9968","original_object":"UniProtKB:Q9HCX4"}
{"id":"be48b518-3764-447d-93ea-3cc4fcac153c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:d2396eb3-c3b4-46bf-ac3d-ecc40d492eef","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:P21817"}
{"id":"a3f0322c-6386-432d-9d5e-6e0e2ad52ba7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6100","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:b2c74981-cdf0-475f-bf03-a2ec652901c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6100","original_object":"UniProtKB:O43603"}
{"id":"089d0315-9cd5-4f37-950e-a11d0ef1ea75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155792249","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:a587b496-a21e-4027-ae11-7f2f946a9d05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12386","original_object":"UniProtKB:O75116"}
{"id":"559ec91b-98b9-4c81-bc8d-5f0f5f37a93d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:8ca51e54-047c-486e-b6fe-3c32751d658d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P08913"}
{"id":"5423e55c-b6dd-44e8-8d3a-184906b453ec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1L1V1K2M4V","predicate":"biolink:affects","object":"NCBIGene:25593","sources":[{"id":"urn:uuid:ae40d82b-712e-4f53-b8c2-6739da3370ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4461","original_object":"UniProtKB:P56718"}
{"id":"141c97ff-070f-439e-8794-4d5662b19281","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3898","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:ebcca613-5505-42a5-9bb0-abada6de6c7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3898","original_object":"UniProtKB:O08726"}
{"id":"6ecd19ad-2649-42ea-be51-e942863d5456","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:5e204a3f-5824-493b-b658-a5017aae9c2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P28335"}
{"id":"2ca7712f-afd0-4d12-ba8a-f9702dd273d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XZ73ATU8W7","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:4f204300-a60e-4fd1-997d-cd98c58dec7a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5950","original_object":"UniProtKB:P11802"}
{"id":"6af6229d-5987-44b0-bb3e-58117b163e72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13196","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:ba2940e4-8e92-48d7-a829-c4ab562e4edc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13196","original_object":"UniProtKB:P13945"}
{"id":"76b3dc82-aeef-461b-ae3f-6d97d285f31e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:c8dda5b3-ec01-46a5-8a2f-ef9e27b5ba61","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q9NZQ8"}
{"id":"e9eb2d61-16ad-443b-ac46-638cd98dff6f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5391","predicate":"biolink:affects","object":"NCBIGene:2642","sources":[{"id":"urn:uuid:5ce88a78-3bd6-4e19-9ef1-891590235916","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1136","original_object":"UniProtKB:P47871"}
{"id":"990013b2-35c3-413a-85fd-0bad4f45bd5e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92180","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:b0b0fdec-ea83-40ba-b982-14365fb65a16","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5620","original_object":"UniProtKB:P29274"}
{"id":"b6c08241-0c49-41d2-983c-1fa40d3551b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:acc3b4b1-32f5-4885-aed1-3b15c78cdb5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P28222"}
{"id":"fe8f7fb7-9ceb-4e01-a91b-8a0928d0e2e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12501","predicate":"biolink:affects","object":"NCBIGene:59350","sources":[{"id":"urn:uuid:322f96e6-9df5-4529-954e-82f1527f40a4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12501","original_object":"UniProtKB:Q9HBX9"}
{"id":"dafb76a8-1b29-4cf9-b30e-bed433a8bdcd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44447430","predicate":"biolink:affects","object":"NCBIGene:102","sources":[{"id":"urn:uuid:a88b670f-f6a7-424d-927d-bb6db3b60260","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8568","original_object":"UniProtKB:O14672"}
{"id":"9c036411-1825-4d4e-8db7-6fae027b6cd0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50924","predicate":"biolink:affects","object":"NCBIGene:5894","sources":[{"id":"urn:uuid:b2c3eae6-a9a7-4b2b-89c7-1fb6ba0f04ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5711","original_object":"UniProtKB:P04049"}
{"id":"c3c268f1-7c98-4b39-bf6d-f19cb99b2c02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1871","predicate":"biolink:affects","object":"NCBIGene:2834","sources":[{"id":"urn:uuid:e8ad3a7a-4b7c-4af1-90f3-529e7f88e61f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1871","original_object":"UniProtKB:P49683"}
{"id":"681ac580-fa17-4c0e-b2f9-510771e00a9f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G8JW58493W","predicate":"biolink:affects","object":"NCBIGene:83810","sources":[{"id":"urn:uuid:11e7f171-fdda-4c64-917c-5052dadb0b04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4130","original_object":"UniProtKB:O35433"}
{"id":"3a99c83f-5e3a-4360-b0b2-6061614611cd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:486830","predicate":"biolink:affects","object":"NCBIGene:1237","sources":[{"id":"urn:uuid:7ffada40-2c7e-41a4-833e-675f4ffaad8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:768","original_object":"UniProtKB:P51685"}
{"id":"480e4a1e-f10e-4884-91e9-49a13db68974","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71540619","predicate":"biolink:affects","object":"NCBIGene:23043","sources":[{"id":"urn:uuid:56386a9e-7682-4fa8-97d9-ae3a5c997c78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8192","original_object":"UniProtKB:Q9UKE5"}
{"id":"7f93210f-0454-4926-9a73-bb8219cda90d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9794910","predicate":"biolink:affects","object":"NCBIGene:158584","sources":[{"id":"urn:uuid:2d755024-a36b-47db-903e-e7677dd91d3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8989","original_object":"UniProtKB:Q6GMR7"}
{"id":"ca0722f0-fcbf-45dd-bb13-b2c70323c051","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:30853","predicate":"biolink:affects","object":"NCBIGene:3290","sources":[{"id":"urn:uuid:1921f7cc-c404-4e76-a855-669e13a24b51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11264","original_object":"UniProtKB:P28845"}
{"id":"1fd04349-68ec-42dc-971d-6df77086d138","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93036","predicate":"biolink:affects","object":"NCBIGene:7177","sources":[{"id":"urn:uuid:c5dee0c9-ddd0-4d5a-a4e7-06cb6dac01f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7863","original_object":"UniProtKB:Q15661"}
{"id":"8eb85cc1-1d60-479d-b348-16f2c8438480","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31622","predicate":"biolink:affects","object":"NCBIGene:2558","sources":[{"id":"urn:uuid:1786c1c2-f89d-4ee5-a73a-e19683541926","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4360","original_object":"UniProtKB:P31644"}
{"id":"e85deb15-ddd7-4967-a4c7-aa7996b2558c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2981","predicate":"biolink:affects","object":"NCBIGene:115004","sources":[{"id":"urn:uuid:6926edb1-3d8c-4231-8fa3-819d650761b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13076","original_object":"UniProtKB:Q8N884"}
{"id":"e53b9008-bf92-4e99-833f-580cee4fce40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10904818","predicate":"biolink:affects","object":"NCBIGene:8698","sources":[{"id":"urn:uuid:09d5fb5e-9654-441a-bb04-b565900f9baa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2937","original_object":"UniProtKB:O95977"}
{"id":"19566360-d28c-4d9f-a5e2-35d13184161c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MAF34143WM","predicate":"biolink:affects","object":"NCBIGene:9475","sources":[{"id":"urn:uuid:b566af8d-f41e-4ee9-a20e-bccc732ca64a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8911","original_object":"UniProtKB:O75116"}
{"id":"93b9af55-c01d-47a9-8341-b23f1bf1c4f8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:558","sources":[{"id":"urn:uuid:4188acd3-1a23-4e54-86f6-316ce2cf0b77","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:P30530"}
{"id":"3f3578ff-f4b0-4638-ba94-86d8a5f93fb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755076","predicate":"biolink:affects","object":"NCBIGene:2899","sources":[{"id":"urn:uuid:d3d35e1a-f0a1-4f9f-8d74-8d3dac0b9ee8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4085","original_object":"UniProtKB:Q13003"}
{"id":"0d357124-79c3-4757-b62e-f765dab06573","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4160662","predicate":"biolink:affects","object":"NCBIGene:8621","sources":[{"id":"urn:uuid:1e62bd49-2c1d-487a-9a14-c992c2faadbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10063","original_object":"UniProtKB:Q14004"}
{"id":"4c15d4f0-114f-4094-b80c-170ec68ce9ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CZ3T9T146K","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:5b71544e-321c-4bdd-981d-ddaa13fa1907","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2132","original_object":"UniProtKB:P29371"}
{"id":"4bb8b739-678f-45e0-91d8-ef312143a565","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699464","predicate":"biolink:affects","object":"NCBIGene:81668","sources":[{"id":"urn:uuid:2da3cf06-ba8a-4b20-a8ad-c0f73ba7ea93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11225","original_object":"UniProtKB:P30969"}
{"id":"cadb1ba6-7594-4a53-9c9e-f7fb6f3c5cfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50867","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:60f3bde7-e4d5-486a-9b3e-4a1681af9def","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3438","original_object":"UniProtKB:Q07869"}
{"id":"ee39e208-c2b7-4f35-82e6-8688859d87bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EK40PJ0V49","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:00c2dedf-4cdb-428f-8361-2aa25d3e6af9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7356","original_object":"UniProtKB:P50406"}
{"id":"ff456041-2107-4671-b03d-6e33dc2569af","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11560568","predicate":"biolink:affects","object":"NCBIGene:729230","sources":[{"id":"urn:uuid:5ba0b90c-c103-4903-8619-32d3d4a808eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3502","original_object":"UniProtKB:P41597"}
{"id":"5c7aa6cc-8d38-4e47-b8fa-0015eb64f990","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9233","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:c747fd03-a437-4ada-994b-1677ede22e47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:99","original_object":"UniProtKB:P28335"}
{"id":"6d53e4ec-325c-4ee2-846c-4f5c0433828d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:612","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:b1d7403e-6080-42ce-9b1f-6ed36e45368c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:612","original_object":"UniProtKB:P52500"}
{"id":"f1fde16b-0ec9-45e0-a930-6c9096a1c341","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:79560","predicate":"biolink:affects","object":"NCBIGene:2891","sources":[{"id":"urn:uuid:b5372001-d084-4e63-9608-728e5aa6a8c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4210","original_object":"UniProtKB:P42262"}
{"id":"50873139-4a15-457c-8154-3ad164280e00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:1fca2f94-90d0-4cc2-9d34-7efa1f1c993d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q92769"}
{"id":"1965611b-173c-4855-b8ef-7945ddcd3266","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16765","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:fa44d958-f230-425a-a61d-ab54b9c6754f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:125","original_object":"UniProtKB:P28221"}
{"id":"59367bbd-4fa7-4b02-a023-0201007f6af3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435378","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:aef71ebc-048d-4b67-8871-3faa61d59050","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1895","original_object":"UniProtKB:P34980"}
{"id":"063aa43a-83a6-4acc-bd43-d178e889a79b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53316647","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:cc3f92c1-3d42-423f-acf5-abf156538409","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:455","original_object":"UniProtKB:P29275"}
{"id":"d0aa37de-cb2f-4a8c-98e5-d513f1310274","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2675","predicate":"biolink:affects","object":"NCBIGene:25187","sources":[{"id":"urn:uuid:e5a2ee6a-6cc5-4beb-83ed-f83c863ce8af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:201","original_object":"UniProtKB:P08909"}
{"id":"210a574a-b1e0-4b25-9c32-b7ceac00aab8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131166","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:f145f1f3-6599-4809-85fc-4425fc424d93","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8003","original_object":"UniProtKB:P48736"}
{"id":"71205b81-eee1-4c76-bf8c-c4fd0a1b0d62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91408","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:5ad58b2e-ec78-400f-97df-1d4f2e2285da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5716","original_object":"UniProtKB:O60885"}
{"id":"0e63a497-d24a-430e-8290-06f6de207bc1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9916412","predicate":"biolink:affects","object":"NCBIGene:81509","sources":[{"id":"urn:uuid:e8dfb8a4-2c19-47e7-931b-42a05c7f4683","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:665","original_object":"UniProtKB:P97583"}
{"id":"6d56efb3-b760-4853-9bc8-429c7182167a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63605","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:5964ca46-b1e8-428b-83b3-33659f34ea47","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6824","original_object":"UniProtKB:P07437"}
{"id":"7f444417-b637-4272-90a3-476032699b08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73337","predicate":"biolink:affects","object":"NCBIGene:99296","sources":[{"id":"urn:uuid:ee01f5a0-3d5d-4aaa-bd8a-316255a7c3cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1236","original_object":"UniProtKB:P58406"}
{"id":"791308ee-a41e-4806-86d0-06960d72590c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2570","sources":[{"id":"urn:uuid:d736f228-7f16-464a-9ba8-9cb4f5d73359","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P28476"}
{"id":"292a3132-6510-4bef-9053-fb7a1e18c8d7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I58WE41H6X","predicate":"biolink:affects","object":"NCBIGene:1723","sources":[{"id":"urn:uuid:8bfbfb8d-bd55-48c9-945a-44e2bc1d978b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12106","original_object":"UniProtKB:Q02127"}
{"id":"050ac0cc-37f6-4d98-9fe9-cc578348dca0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:2556","sources":[{"id":"urn:uuid:ac22506e-2a92-4416-80b4-1c018d37a95a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:P34903"}
{"id":"94530fc1-79b0-49ec-84c7-3ad5ea64a5ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53325948","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:55ce508b-3826-42e8-9a60-8911775f0ced","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:119","original_object":"UniProtKB:P28222"}
{"id":"95cbddf4-2632-4683-80f9-8be2e7c21379","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O43472U9X8","predicate":"biolink:affects","object":"NCBIGene:931","sources":[{"id":"urn:uuid:0dda2ad6-63bb-4202-ae2e-4876be68dc41","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:6941","original_object":"UniProtKB:P11836"}
{"id":"97e0c973-a754-4b79-b438-15e716e49e62","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2261","predicate":"biolink:affects","object":"NCBIGene:117","sources":[{"id":"urn:uuid:fa1d0529-b150-46f3-9de5-856c23f3c53b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2261","original_object":"UniProtKB:P41586"}
{"id":"b228cb88-0a57-423b-8d66-a4af2a852a91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15544","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:d6a4bd51-5ce2-4a11-baad-9ac398c8549b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1882","original_object":"UniProtKB:P35408"}
{"id":"beb12872-2a52-4086-be83-36907261e55c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:168SF9F04E","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:f6d248d1-88ae-4a8a-9f3b-076d3a0d15ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5617","original_object":"UniProtKB:P30542"}
{"id":"bfb9c015-a2d3-489a-91e1-29a3c52a68ca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:83501","predicate":"biolink:affects","object":"NCBIGene:259290","sources":[{"id":"urn:uuid:f5b931fe-2e22-4795-a30d-134774de6de9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12460","original_object":"UniProtKB:P59538"}
{"id":"c0a4b976-4084-464e-9939-2db5134f94ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221840","predicate":"biolink:affects","object":"NCBIGene:5578","sources":[{"id":"urn:uuid:df214be8-2aea-42e4-bf8b-5d53f4fd886b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7907","original_object":"UniProtKB:P17252"}
{"id":"d99a9ded-250c-4496-9a0e-f73092f605d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92537","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:95eb981c-f818-484c-bb86-98ac40ff4d6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:28","original_object":"UniProtKB:P28223"}
{"id":"1c03079d-2c7b-4117-a1e1-6b1b895dc5c2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2064","predicate":"biolink:affects","object":"NCBIGene:6753","sources":[{"id":"urn:uuid:3aeaf840-a85b-4402-836f-478119f7ddec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2064","original_object":"UniProtKB:P32745"}
{"id":"ca0e7d9d-c5bb-499c-a18d-e8809588bd78","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699437","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:8daa2691-3d06-4a57-b7cd-6eb0c4d2f1b7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7648","original_object":"UniProtKB:P35968"}
{"id":"49e78d99-f359-4fd3-a4e2-c2247841ec4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8652","predicate":"biolink:affects","object":"NCBIGene:1236","sources":[{"id":"urn:uuid:5d4b3370-95eb-402c-bcbd-225cf9be7d6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8652","original_object":"UniProtKB:P32248"}
{"id":"961c465c-d4a5-41f9-8814-6b572a974f72","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:81529","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:8353c457-0f09-4019-9578-403f1c087679","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1642","original_object":"UniProtKB:P41143"}
{"id":"c2473e4a-ce99-4866-8f23-8c8866f08eb0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9408","predicate":"biolink:affects","object":"NCBIGene:24088","sources":[{"id":"urn:uuid:53b85348-766f-4737-8df4-7c3db3017d2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:9408","original_object":"UniProtKB:Q9QUN7"}
{"id":"e8cb7b37-2894-4e6c-a2d9-4ad751a9c874","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9840090","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:a6844e4f-f831-4fa8-b648-ee6abaf1401a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:157","original_object":"UniProtKB:P28223"}
{"id":"fa88736b-d53d-42bf-9f05-78603d24ccca","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16062593","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:ce242c55-25ab-424b-a3f6-3150b367c6b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1407","original_object":"UniProtKB:Q14833"}
{"id":"5d170196-51e9-433b-b2d8-99c678ce87da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947005","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:ef20b297-f3d6-4382-b228-0c9408f57177","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3211","original_object":"UniProtKB:Q62967"}
{"id":"7fe39520-ae65-4d38-b74f-5490b18d2c80","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:G2AE2VE07O","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:23332702-72d4-4346-9a61-bc91da227190","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10129","original_object":"UniProtKB:P11229"}
{"id":"42855a1d-c3af-4fa1-8c9f-5e84bff43f18","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134604213","predicate":"biolink:affects","object":"NCBIGene:284111","sources":[{"id":"urn:uuid:9c8989ce-c5bc-4f84-9b15-d60412e3136e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11242","original_object":"UniProtKB:Q86YT5"}
{"id":"d6d36bbb-d583-4811-9e86-06640fdc8e14","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:314","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:3f518785-111e-4f17-b9fa-cda5c2252a15","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:314","original_object":"UniProtKB:P08172"}
{"id":"77a4f9ff-e7b1-4b26-a1a5-dbcc2c43f557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:391960","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:f249e185-33da-4b63-9563-92bbc21b9730","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:321","original_object":"UniProtKB:P20309"}
{"id":"64a9c075-4ec7-4465-ab86-b8e22e6dd251","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:0CA0VSF91Y","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:ffea49cb-ee7c-4f3f-ba89-83fb688da8d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11410","original_object":"UniProtKB:O60674"}
{"id":"bef25d29-17ec-493f-80e0-01d6e56c7876","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34970","predicate":"biolink:affects","object":"NCBIGene:6334","sources":[{"id":"urn:uuid:a8970fc4-51b5-4db3-a02d-5aa7470dc835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2625","original_object":"UniProtKB:Q9UQD0"}
{"id":"a905eee6-5122-45ec-b95b-5e9d9dc8e2b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:3035974","predicate":"biolink:affects","object":"NCBIGene:2906","sources":[{"id":"urn:uuid:b521ebb7-6c4a-4e8e-b23c-ba3ac5490c64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4243","original_object":"UniProtKB:O15399"}
{"id":"a8477e93-af4c-4820-9410-40317ea1b880","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311003","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:b3f95f72-b5aa-48f9-a360-c2ecd5e29a59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1600","original_object":"UniProtKB:P34975"}
{"id":"89da20dc-0d12-49ce-b33c-6a7ada8cafa3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10056","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:3d25cf1c-454c-4eb3-9161-1aad65856212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:57","original_object":"UniProtKB:P28222"}
{"id":"d308b284-ec27-4bc7-860c-5a9ad121759e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70K4BF31QF","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:ea1c3ce5-7b41-4992-bb72-fe17ec199ce5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1913","original_object":"UniProtKB:P43088"}
{"id":"bdb95c80-a0cb-4d75-90b7-4a98bfb2c579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1307","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:e70c93e2-1624-45d7-a551-da3f9c35bfdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1307","original_object":"UniProtKB:Q969V1"}
{"id":"8ac4e144-aee8-487c-8c59-88857cafaced","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:9cb79b70-d02d-48ad-b4d6-5f1bc351a89f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P35408"}
{"id":"c0dd827e-1142-4150-a003-b36db7c0aa9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:516","predicate":"biolink:affects","object":"NCBIGene:81727","sources":[{"id":"urn:uuid:a4efacc5-06cd-425c-87b1-ed9798354551","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"feedback_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3055","original_object":"UniProtKB:P17256"}
{"id":"87f1686b-42c9-45df-bab6-6033b53f9613","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34541","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:bc82b3a4-e924-41e4-84bb-04416a3f408e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4138","original_object":"UniProtKB:P48058"}
{"id":"bccdb4e5-8bef-422b-ba34-2f1105edbbaa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7459","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:af8970f3-036c-4f59-b589-89f22c58569a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1676","original_object":"UniProtKB:P33535"}
{"id":"bab2cef3-60c5-4ad7-a53c-6dd172d1bec5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2113","predicate":"biolink:affects","object":"NCBIGene:6865","sources":[{"id":"urn:uuid:89d71560-db6b-41a0-bee3-1192a6300505","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2113","original_object":"UniProtKB:P21452"}
{"id":"5b4cd79b-b07d-4d03-87ba-c4a13787eedb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37659","predicate":"biolink:affects","object":"NCBIGene:5423","sources":[{"id":"urn:uuid:4d7eeb2c-7ce6-4546-8497-6a8932f95c62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3306","original_object":"UniProtKB:P06746"}
{"id":"7e56dd77-95d2-4abe-b4d1-927aa15f7d5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56597775","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:9e240410-57df-40c1-adf9-de6d154093d5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8213","original_object":"UniProtKB:P08581"}
{"id":"6dbac8dc-66ec-48b6-aaec-064c68946c29","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16108961","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:c9dbee6b-4958-40b6-8e57-bfd1133d8f65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:664","original_object":"UniProtKB:P46663"}
{"id":"732a4c98-f5df-4bf8-8258-4878af55b499","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155326246","predicate":"biolink:affects","object":"NCBIGene:2872","sources":[{"id":"urn:uuid:e88d01c1-b0cb-453a-99d1-30a3ebf0ebcc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13310","original_object":"UniProtKB:Q9HBH9"}
{"id":"35175cc7-4236-4170-8bbf-c22d3ba4c6ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:143117","predicate":"biolink:affects","object":"NCBIGene:6098","sources":[{"id":"urn:uuid:126e5e0f-203d-4b02-8612-868fdcfed0cb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7476","original_object":"UniProtKB:P08922"}
{"id":"8cd957f7-1be8-4bd8-8b02-7ee3a88540f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:129606875","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:c0139982-e394-4f4a-8eb6-3c5ea5dc4fd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10626","original_object":"UniProtKB:Q86V86"}
{"id":"dbe0410f-2156-4842-aa25-ceee36dcf360","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:707","predicate":"biolink:affects","object":"NCBIGene:127534","sources":[{"id":"urn:uuid:0008e74c-5c27-4b0d-aafa-c4a9aff5f7be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:707","original_object":"UniProtKB:Q9NTQ9"}
{"id":"5c1f8538-69af-4466-8e4e-8a3e49195555","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4016","predicate":"biolink:affects","object":"NCBIGene:10886","sources":[{"id":"urn:uuid:705957ca-c2fd-4dca-93ba-acc22a4683d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4016","original_object":"UniProtKB:Q9Y5X5"}
{"id":"37ca0b62-7b57-4d11-be4c-4eb676650ff2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16118894","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:4e2cfd65-21b3-4c10-b7af-11f4de52b479","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3467","original_object":"UniProtKB:P13945"}
{"id":"076d4294-114a-433b-a2ca-403612383cc8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25223366","predicate":"biolink:affects","object":"NCBIGene:6507","sources":[{"id":"urn:uuid:66a9937e-ab8d-4a2e-9753-9dbd07ded9f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4609","original_object":"UniProtKB:P43003"}
{"id":"a849c93a-96e5-4742-8357-a84759ef575d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:142620206","predicate":"biolink:affects","object":"NCBIGene:728","sources":[{"id":"urn:uuid:38f9b24d-18ce-4c9c-9c30-c5a245f70e28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12326","original_object":"UniProtKB:P21730"}
{"id":"ea9db38c-e78f-48a4-80f4-562de0030255","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139592939","predicate":"biolink:affects","object":"NCBIGene:1595","sources":[{"id":"urn:uuid:efe245cc-9755-4d1a-9fc5-897240c81bdd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10548","original_object":"UniProtKB:Q16850"}
{"id":"8496af5d-bc99-45ec-b8a4-faabfb9ab9c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3V7GQ1260K","predicate":"biolink:affects","object":"NCBIGene:3716","sources":[{"id":"urn:uuid:2432f7fd-9ac1-4621-abac-ceb2de22e778","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9697","original_object":"UniProtKB:P23458"}
{"id":"496070c9-fde4-42c6-a483-11bf4f825426","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:119915","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:8eb51725-4e04-4c71-b5ec-8000e509e4e5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1626","original_object":"UniProtKB:P41145"}
{"id":"a49648db-8e36-4811-9943-9093ddefa196","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:U2H19X4WBV","predicate":"biolink:affects","object":"NCBIGene:8569","sources":[{"id":"urn:uuid:0fabdbe0-c467-4f17-87db-fa9010c18521","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10167","original_object":"UniProtKB:Q9BUB5"}
{"id":"4e01bce1-2c5c-400f-b30a-aa75c3b8c64b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45906","predicate":"biolink:affects","object":"NCBIGene:5029","sources":[{"id":"urn:uuid:f9d8663a-0611-4d77-873b-8dcf3aa015af","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1728","original_object":"UniProtKB:P41231"}
{"id":"292f51ed-0c1f-4ffe-82df-38ddabc61fac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:77e76264-7f56-4f2e-8905-60b8d4378b42","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:203","original_object":"UniProtKB:P31645"}
{"id":"4730620b-b68d-41a8-be0c-34e005d44bec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:43876","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:1e0248d8-0cd3-4ca7-8877-545f90a71207","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1373","original_object":"UniProtKB:Q14416"}
{"id":"a123b033-4def-40a6-9020-fcd9af8175f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8665","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:8c79f84e-df2c-4612-b4ed-e4538b0eeee6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8994","original_object":"UniProtKB:P22303"}
{"id":"a7bda22a-f6cd-49c8-bb04-cb09e2f29bc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:920","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:c78e7fd1-2a9d-4620-add0-aaf20ee300ca","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:920","original_object":"UniProtKB:Q60748"}
{"id":"718172ba-4890-4248-8561-2e5f11461027","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9937534","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:41659c81-8b85-4f77-8c76-fca521ecb231","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:621","original_object":"UniProtKB:P28336"}
{"id":"574aaeb5-bd92-4afa-8d67-8de308c6e25b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71533368","predicate":"biolink:affects","object":"NCBIGene:19697","sources":[{"id":"urn:uuid:b5313ea2-0af8-46d4-8d0b-38234ecd6b7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13327","original_object":"UniProtKB:Q04207"}
{"id":"65288a95-265a-4c86-ab20-7f90d709592f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24938285","predicate":"biolink:affects","object":"NCBIGene:4891","sources":[{"id":"urn:uuid:b6d67856-e453-4f5d-8159-e1789603d0ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8814","original_object":"UniProtKB:P49281"}
{"id":"e909138d-efe2-4827-b3ed-7c87dd67ccd6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16335","predicate":"biolink:affects","object":"NCBIGene:54795","sources":[{"id":"urn:uuid:737975ca-bf9a-4567-9a48-300617db5ac7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2844","original_object":"UniProtKB:Q8TD43"}
{"id":"d172e9a5-aa01-49f1-86db-d0f9c6f07e05","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:35025716","predicate":"biolink:affects","object":"NCBIGene:56413","sources":[{"id":"urn:uuid:e1bdf984-7992-411c-b0eb-1e82402f57d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3351","original_object":"UniProtKB:Q9NPC1"}
{"id":"788595c0-3d2f-4619-8504-ab999d1b2dbe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230497","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:1f4d7697-0757-4458-bee0-240bf58a1921","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9105","original_object":"UniProtKB:P10721"}
{"id":"ceb41c53-07da-4ff4-95e0-e5bdea616e02","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:61400","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:70671126-b33e-4dd1-be1b-0373e42b3781","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9176","original_object":"UniProtKB:Q06187"}
{"id":"0a157740-13ed-46b6-88fa-2c4388debbfe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91807","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:48536d39-3f5e-4a80-8ed5-9010d099a6b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12578","original_object":"UniProtKB:P08588"}
{"id":"db69d750-5329-4372-b92a-bc8085903f4b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9947811","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:433d5205-7165-4dca-be4d-b05481bdbdbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6124","original_object":"UniProtKB:P47211"}
{"id":"51aaff06-86d3-49ba-a576-9ec96e71b82b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6435286","predicate":"biolink:affects","object":"NCBIGene:10800","sources":[{"id":"urn:uuid:765ab7b7-6782-46db-9fa9-fa195c616f07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3412","original_object":"UniProtKB:Q9Y271"}
{"id":"59813574-1d6d-4324-ad4d-c9ece22b084a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:313","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:6d764ed0-37b9-48c4-9e5f-99883b4872d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:313","original_object":"UniProtKB:P08172"}
{"id":"92d36337-b77b-48f2-84bb-df3181345b99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:P5HNG5UF2U","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:4c949c6c-bc5d-4c0e-a2c6-ca52d02d9c52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11885","original_object":"UniProtKB:P11802"}
{"id":"72251503-ac42-4bed-9281-23488755987c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:25CG88L0BB","predicate":"biolink:affects","object":"NCBIGene:25423","sources":[{"id":"urn:uuid:5efbf02e-5c44-49a0-8d16-6d27590636e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9412","original_object":"UniProtKB:P80067"}
{"id":"fa88b27e-bc2c-49e1-8448-b38fa41a387c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64217","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:19072a84-5e88-4326-a214-7160a14d292c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:983","original_object":"UniProtKB:P35462"}
{"id":"0c897247-4398-4ce3-874c-55afc3f83f66","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92357","predicate":"biolink:affects","object":"NCBIGene:246","sources":[{"id":"urn:uuid:e42399bb-e17e-433c-b209-f548103a481e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8751","original_object":"UniProtKB:P16050"}
{"id":"cb192bd2-183a-40c1-868b-b056e5ede307","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9316","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:5c978926-f0cb-4fd3-ae89-5e543eab6e70","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3534","original_object":"UniProtKB:P33535"}
{"id":"7d50f952-03a5-4aa9-92ed-55b58f7ca75b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46557","predicate":"biolink:affects","object":"NCBIGene:83791","sources":[{"id":"urn:uuid:becf561b-45e7-4f97-9c51-f5cb55e8ee8c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3177","original_object":"UniProtKB:P05369"}
{"id":"76ba632f-c364-4e3a-b45d-0ed82b176e57","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10358392","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:46a91096-5f49-433a-a8bc-81ec4b1ba2a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:66","original_object":"UniProtKB:P28222"}
{"id":"9f77799f-797d-42a5-adc5-273c6b028055","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:2e6c4099-657a-4dc8-94ed-ac329b1f881f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08482"}
{"id":"e474d919-17ff-423f-be8f-b3e153015ef3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2814","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:63255cb3-7216-4e63-b212-722931aee67c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:296","original_object":"UniProtKB:P08172"}
{"id":"38b1368f-ea84-4db2-aaa0-27710445537c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110160","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:1eb2d54e-a3a4-4623-a6b1-7e58cfe5646d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1358","original_object":"UniProtKB:P49286"}
{"id":"99618594-876c-49ad-9be7-581dce512983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9891980","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:18b94541-a02f-48f0-bdae-fc4062ac4138","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8459","original_object":"UniProtKB:P35368"}
{"id":"1275509b-4c70-4d0e-80aa-6725eb604521","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8680B21W73","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:13189ae8-675f-441a-90e7-21167e0d932c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9745","original_object":"UniProtKB:Q92847"}
{"id":"cc369096-9f74-4322-bb32-d57435fcb722","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6178","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:47808c9a-bcce-44f6-997c-5e6b19a5812f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6178","original_object":"UniProtKB:P30550"}
{"id":"8c403df8-a78d-4d64-9a08-529e26112d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135443367","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:098d8929-e95a-4b60-9afc-d56908312777","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:382","original_object":"UniProtKB:P29275"}
{"id":"3e6dd80f-5b77-47e3-865c-38467bdd43e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10371065","predicate":"biolink:affects","object":"NCBIGene:2289","sources":[{"id":"urn:uuid:398e897e-b2f6-4e5b-889b-b4a8748e3f84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11480","original_object":"UniProtKB:Q13451"}
{"id":"f672699e-9d5c-436d-8a22-e3956c49a39e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72317","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:e1b8a77d-d256-4d2e-b25b-d5a32d5adbb1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5887","original_object":"UniProtKB:P08581"}
{"id":"c90fd2ec-ae1a-44b0-a1ac-70f6f04243cf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2D9N67F58G","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:7a33eaf9-78c9-4cab-ac6d-78205c14d488","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5691","original_object":"UniProtKB:Q96GD4"}
{"id":"8a5573ec-9760-4894-b427-1de26a4bcac4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5641","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:06d372cd-63e7-415d-8256-5e18a21db4b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5641","original_object":"UniProtKB:P30874"}
{"id":"e8955c0f-b1c4-40b1-9884-7ab1045050de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321170","predicate":"biolink:affects","object":"NCBIGene:8876","sources":[{"id":"urn:uuid:7718a78f-3b81-4d44-9011-a6ed164c4494","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10201","original_object":"UniProtKB:O95497"}
{"id":"cd2b7741-0fe1-486a-9847-72af6d23674d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1515","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:e62a483b-cf2f-4334-8893-d3e4579f45f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1515","original_object":"UniProtKB:P49146"}
{"id":"553161f6-d81d-4347-a6f9-b674d3e6b27a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73386890","predicate":"biolink:affects","object":"NCBIGene:5601","sources":[{"id":"urn:uuid:32cf0b26-f43b-4634-bc1d-7a8d5e352661","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12706","original_object":"UniProtKB:P45984"}
{"id":"2e749a8f-3b68-474a-a23e-653b74d22ddc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75393","predicate":"biolink:affects","object":"NCBIGene:6093","sources":[{"id":"urn:uuid:4e4ffa83-f52f-4d16-8d8e-573a676a5c3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5290","original_object":"UniProtKB:Q13464"}
{"id":"56850205-2527-4bd2-8b8f-cd6f4b424cd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44186581","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:dfd1d3e8-dc94-4ca5-8c69-de1d2e7f806b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6561","original_object":"UniProtKB:P29275"}
{"id":"b1f8078c-b964-4e82-8c59-33b2851d0b84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311358","predicate":"biolink:affects","object":"NCBIGene:3708","sources":[{"id":"urn:uuid:9d87be99-9b90-4a63-968a-3dcb40b25563","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2387","original_object":"UniProtKB:Q14643"}
{"id":"3ed2ab9e-e64e-4b16-9493-45a8e36fd9eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:2064","sources":[{"id":"urn:uuid:9af7e9c3-6d02-4c4f-98c2-7fc7aba2bea2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:P04626"}
{"id":"38028154-956a-4482-99ca-cf272974e933","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145946134","predicate":"biolink:affects","object":"NCBIGene:1509","sources":[{"id":"urn:uuid:10fdd2b2-2687-4eeb-88c9-ee8e46e9648c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10680","original_object":"UniProtKB:P07339"}
{"id":"2bf26cb9-ee51-4983-bb79-22b2d8250213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2346","predicate":"biolink:affects","object":"NCBIGene:140803","sources":[{"id":"urn:uuid:b39ea0ea-ea83-4ae2-a1cc-c8b013ee8a2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"potentiation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2346","original_object":"UniProtKB:Q9BX84"}
{"id":"720a7af5-c006-40dd-9c69-0575b01fbafe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:57R7D1Q49R","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:afeb5d56-694f-43a1-83f4-22007f0ec4be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10712","original_object":"UniProtKB:P11229"}
{"id":"bc2e733b-ffb0-4111-8a1e-109901b49495","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91465","predicate":"biolink:affects","object":"NCBIGene:5170","sources":[{"id":"urn:uuid:5daf7f03-037e-4be0-adf3-4aee98852cdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8008","original_object":"UniProtKB:O15530"}
{"id":"0b3c3451-69c8-45c2-b6ed-4f9309cf52b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3411","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:9abc8521-be88-4891-8f32-c046ae8d99b6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3411","original_object":"UniProtKB:P25090"}
{"id":"f0c6a35d-1c82-4172-89bd-71d495f4f3a8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:141754136","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:203b7ecd-251b-4144-8b08-deb956241b05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11204","original_object":"UniProtKB:P48736"}
{"id":"60b6c785-2a08-4547-99ff-79c30f971ad3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3ZX95B1ZWK","predicate":"biolink:affects","object":"NCBIGene:4543","sources":[{"id":"urn:uuid:2837c935-dcad-4ff4-b54e-31c081ed14b1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1351","original_object":"UniProtKB:P48039"}
{"id":"736c3234-8f5d-4f3f-a4e1-b681f7d6ab85","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231618","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:100ce7db-1861-476e-a0a6-2c8114e601be","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2817","original_object":"UniProtKB:P03372"}
{"id":"f384d64f-cda4-47ce-afb7-27478cdda403","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:337298","predicate":"biolink:affects","object":"NCBIGene:2798","sources":[{"id":"urn:uuid:aa76be7c-2cb5-4f21-af07-4a44b6664835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1188","original_object":"UniProtKB:P30968"}
{"id":"84c302c1-ccf0-4ff2-86e6-958390755c91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310979","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:2bbe0d50-064f-4f3a-afd6-e54f935510a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1377","original_object":"UniProtKB:P31422"}
{"id":"62125332-27c5-4cb8-93c7-1f9ae7e4acc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154663238","predicate":"biolink:affects","object":"NCBIGene:10000","sources":[{"id":"urn:uuid:726138a1-4fe4-4f79-8df5-06fe7d0a9041","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12112","original_object":"UniProtKB:Q9Y243"}
{"id":"3f30b0f8-37b0-471f-a39e-11ec32c893c6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:166625099","predicate":"biolink:affects","object":"NCBIGene:9730","sources":[{"id":"urn:uuid:7d205b62-2151-4a6c-b461-78786c33ca6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12817","original_object":"UniProtKB:Q9Y4B6"}
{"id":"f16c0bfd-45c5-49a1-aa92-2d75f4a0535f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:167654","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:897c9fc1-a722-448f-af5c-b5c61df71450","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3381","original_object":"UniProtKB:Q9NS75"}
{"id":"775d748d-2dfe-4321-b7ed-7327aa3683de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63610","predicate":"biolink:affects","object":"NCBIGene:5734","sources":[{"id":"urn:uuid:4a526639-9cdc-49f0-91b4-628d1755a0fa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1936","original_object":"UniProtKB:P35408"}
{"id":"a05ab06e-45aa-4632-be25-479c8a80bd5f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2639","predicate":"biolink:affects","object":"NCBIGene:40","sources":[{"id":"urn:uuid:2ef3e43c-a4eb-4830-8e89-70725f76d560","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2421","original_object":"UniProtKB:Q16515"}
{"id":"f364e74f-dccb-4ca2-8bc5-71fd028b3c0c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:66561876","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:d4cf4ed8-df1c-436e-bc2e-cb9f593f0b56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8626","original_object":"UniProtKB:P08246"}
{"id":"f9fb1546-a967-4eff-a327-bd31112bfb44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3654","predicate":"biolink:affects","object":"NCBIGene:23632","sources":[{"id":"urn:uuid:fac5cacd-d731-4d2d-847f-ac0a03072efb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7147","original_object":"UniProtKB:Q9ULX7"}
{"id":"21359170-0ce0-42ff-a545-bacf2bc986b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229220","predicate":"biolink:affects","object":"NCBIGene:4916","sources":[{"id":"urn:uuid:63cf8920-a24c-41ee-9720-2f6b02747e14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10316","original_object":"UniProtKB:Q16288"}
{"id":"9421d096-346d-40a9-8eae-b88c66b25ccd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13576","predicate":"biolink:affects","object":"NCBIGene:5136","sources":[{"id":"urn:uuid:7fea926a-8ab1-4989-a09b-152aa2e68829","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13576","original_object":"UniProtKB:P54750"}
{"id":"cd727f7a-32d3-4a2c-ab0a-3a5d123bc841","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134724","predicate":"biolink:affects","object":"NCBIGene:25552","sources":[{"id":"urn:uuid:b91316b5-9180-459a-805f-fd64c0f88690","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9394","original_object":"UniProtKB:P53790"}
{"id":"63f86de8-9841-4275-8715-2e24d8bbc0fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:136666","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:c79aebc8-75dc-4b58-a11b-fcfe07fe3da3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13862","original_object":"UniProtKB:P35968"}
{"id":"1fc8ddcd-687e-4d80-ab0f-576342692d26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:83727bad-df3c-4ec9-8ba8-57e60712c641","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:P52333"}
{"id":"952d63e9-87db-4d8f-9928-63b833cec55b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47426","predicate":"biolink:affects","object":"NCBIGene:6558","sources":[{"id":"urn:uuid:240cee6e-bc3c-4841-b420-7c17568d471c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4839","original_object":"UniProtKB:P55011"}
{"id":"a9a5f91b-38c0-4c54-ae35-41648d2975c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16188","predicate":"biolink:affects","object":"NCBIGene:2700","sources":[{"id":"urn:uuid:312099db-f5cd-4181-81b3-378f8e98f454","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4278","original_object":"UniProtKB:Q9Y6H8"}
{"id":"6d62e249-2e3f-4a03-a987-fa259e08451a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:110187","predicate":"biolink:affects","object":"NCBIGene:5053","sources":[{"id":"urn:uuid:903c0bdd-b99c-4dd5-b4dd-3defce519f84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5240","original_object":"UniProtKB:P00439"}
{"id":"fd058989-29ad-4a29-ac9d-8105fa288ed6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3X8387Q25N","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:cb1ab419-5868-4513-9aad-b075733338f9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10459","original_object":"UniProtKB:P29597"}
{"id":"8cdd25d1-53e3-4fb8-8b1f-492bb3f2a2ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32243","predicate":"biolink:affects","object":"NCBIGene:8644","sources":[{"id":"urn:uuid:b7d701c0-8d63-4b73-80f5-d1ca2563ab62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8769","original_object":"UniProtKB:P42330"}
{"id":"7bfc1498-f8a5-47a2-be78-65510255bd51","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:C88817F47Y","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:50be9ea7-da1e-489d-bb57-55afec1e51ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8918","original_object":"UniProtKB:P42336"}
{"id":"1303ec2c-1ac3-4c19-be54-5dfb52f4fef0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2564","sources":[{"id":"urn:uuid:2d11f960-d510-49f1-8015-c830c2563a53","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P78334"}
{"id":"503f14b1-790c-4cb6-94f8-54f772532031","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:132991","predicate":"biolink:affects","object":"NCBIGene:1909","sources":[{"id":"urn:uuid:77896ab3-8eea-43ee-93eb-25b3ebd88776","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1001","original_object":"UniProtKB:P25101"}
{"id":"9791a05b-e4c0-4a8b-b945-335157045136","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:708","predicate":"biolink:affects","object":"NCBIGene:6261","sources":[{"id":"urn:uuid:7f3ecad1-2c95-4ff8-941e-cffbc27821c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:708","original_object":"UniProtKB:P21817"}
{"id":"a57e0509-a75b-420d-88c5-e2be2fe1bbce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311029","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:e32f11a1-ff85-4a3a-95fa-677a4ff369ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:234","original_object":"UniProtKB:Q13639"}
{"id":"5906cf76-e2b8-4230-b2c4-e1fab214a82b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94686","predicate":"biolink:affects","object":"NCBIGene:747","sources":[{"id":"urn:uuid:b4a34ec0-b9f7-444b-8b95-f487f7d56f69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5277","original_object":"UniProtKB:Q9Y4D2"}
{"id":"d82d23ca-0cb6-4c58-8ef8-80af81989c93","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:21123938","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:6b58494e-3834-4439-aefb-b0206e6dd8e9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:343","original_object":"UniProtKB:P08173"}
{"id":"558fea8f-3249-41c2-a1fd-a7101a885786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230490","predicate":"biolink:affects","object":"NCBIGene:5914","sources":[{"id":"urn:uuid:eb128cb0-6b20-4297-b723-a510ed42400f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2650","original_object":"UniProtKB:P10276"}
{"id":"eb1e819b-ebb6-4295-9435-b82479045faa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2319","predicate":"biolink:affects","object":"NCBIGene:54262","sources":[{"id":"urn:uuid:fdba8899-0805-43cf-973f-920c3bb41a03","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2319","original_object":"UniProtKB:P70604"}
{"id":"d087030b-3285-40f2-abab-608ff413b95d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:162641696","predicate":"biolink:affects","object":"NCBIGene:1024","sources":[{"id":"urn:uuid:0f3866d0-58ad-4810-a866-2272c73f0e24","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11842","original_object":"UniProtKB:P49336"}
{"id":"c4ec78de-c68e-4115-862d-cae3baeb16db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51860","predicate":"biolink:affects","object":"NCBIGene:6531","sources":[{"id":"urn:uuid:55ef7cf3-8877-47f1-9ecf-ba31f9b1d0e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7554","original_object":"UniProtKB:Q01959"}
{"id":"93813737-c7f6-4a06-9662-8cc20e076d67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9824507","predicate":"biolink:affects","object":"NCBIGene:6915","sources":[{"id":"urn:uuid:b36e25c0-104e-4669-919d-8ad62b77daa8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1920","original_object":"UniProtKB:P21731"}
{"id":"0445525d-00cb-4220-b8b2-b0ca58ca32f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:73I34XW4HD","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:85eb0cd7-3ef4-43ee-92e3-d6c84ed52e20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7959","original_object":"UniProtKB:P00533"}
{"id":"8c96d34a-59c6-46e6-a3b5-f8c0d4c21cb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10430549","predicate":"biolink:affects","object":"NCBIGene:1903","sources":[{"id":"urn:uuid:d63b843f-3679-4a34-bfe4-e70db03feba9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2929","original_object":"UniProtKB:Q99500"}
{"id":"d6533005-8a84-44e2-8e19-f0e6f26408eb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:447180","predicate":"biolink:affects","object":"NCBIGene:24598","sources":[{"id":"urn:uuid:bcc05a35-d881-4c59-a8b5-22ebc912258f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6525","original_object":"UniProtKB:P29476"}
{"id":"dcc00eb2-baa2-4ce5-9986-4baf6924bbfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73467","predicate":"biolink:affects","object":"NCBIGene:24260","sources":[{"id":"urn:uuid:82da95c0-a763-43a5-bf43-968d6a5f4113","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:307","original_object":"UniProtKB:P08483"}
{"id":"da9df584-1a3e-43fd-ba4d-13b266a4d73c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35046","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:be119f20-3744-4f83-90c4-ef192f6d6c21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2596","original_object":"UniProtKB:O43526"}
{"id":"d1d9df47-79e5-4d2d-a16d-1e410c43f971","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9674","predicate":"biolink:affects","object":"NCBIGene:2555","sources":[{"id":"urn:uuid:c4d02df6-2600-42d9-bb79-06baaa20730e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7313","original_object":"UniProtKB:P47869"}
{"id":"7385f74e-1f5e-4d89-8e88-33332b7aa22c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94802","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:f5d04e9e-94a6-4ffd-9a9f-5704f4bf43aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2172","original_object":"UniProtKB:P47901"}
{"id":"59d0f8a8-e438-4e0c-8928-845b1a340fc0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9713","predicate":"biolink:affects","object":"NCBIGene:7046","sources":[{"id":"urn:uuid:54900667-b042-49cd-96bb-47f5e122a361","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9713","original_object":"UniProtKB:P36897"}
{"id":"f46117f3-b017-415e-ae8f-f962d605f8cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5BKJ4Z6RBU","predicate":"biolink:affects","object":"NCBIGene:238","sources":[{"id":"urn:uuid:80b08a8b-95a1-4abb-a3d2-f6751ed5de99","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12388","original_object":"UniProtKB:Q9UM73"}
{"id":"395b2157-6e1f-4b8d-98fb-9e7e00a6a09d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123773279","predicate":"biolink:affects","object":"NCBIGene:65980","sources":[{"id":"urn:uuid:c319c4d4-7a2a-49e9-9a98-a4af69036df6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9522","original_object":"UniProtKB:Q9H8M2"}
{"id":"6c691808-b60b-4b1c-b262-5bef7ced6ae9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65329","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:57188a03-68a7-48c2-ab27-986780974116","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6004","original_object":"UniProtKB:P25440"}
{"id":"688ab1f2-8559-4b59-81d0-f6d0c994c616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:229236","predicate":"biolink:affects","object":"NCBIGene:6870","sources":[{"id":"urn:uuid:272c8af0-c88e-46c7-8bcc-68bcabe2fe0f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10422","original_object":"UniProtKB:P29371"}
{"id":"5c712cec-f00f-4819-9070-b5ae5eb801c5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6099","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:cb6f2669-b8b9-4888-b22c-d024556ededa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6099","original_object":"UniProtKB:P47211"}
{"id":"90c87f1e-fb33-457c-88b8-642ab45fa1a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92658","predicate":"biolink:affects","object":"NCBIGene:2932","sources":[{"id":"urn:uuid:a7a3308c-8d59-40e5-a043-735296181a92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6000","original_object":"UniProtKB:P49841"}
{"id":"1d88f1ca-38c1-4d19-a5d6-dba3d40c9f55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13130","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:1ee4f85f-a70e-40f9-b617-40b135a53c60","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13130","original_object":"UniProtKB:P18825"}
{"id":"367595a8-2fd3-4d5f-864a-4ea1a31eba12","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77543","predicate":"biolink:affects","object":"NCBIGene:43740578","sources":[{"id":"urn:uuid:8802a469-01c2-48d7-803b-39617fddd87d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10583","original_object":"UniProtKB:P0DTC1"}
{"id":"cd7fbabf-da37-402a-b4f7-b38e7bbbd8d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93369","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:592f802b-ccb3-419e-a0ea-f0e08844dd62","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:85","original_object":"UniProtKB:P08908"}
{"id":"a2cbbadd-ec9a-4060-a007-93d9e2038258","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5DS173ODI4","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:13c164e3-065e-4cbe-a83d-59872160ba51","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1444","original_object":"UniProtKB:O43193"}
{"id":"d62800e7-d85a-47e3-a40c-f0c7de165970","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73337","predicate":"biolink:affects","object":"NCBIGene:170704","sources":[{"id":"urn:uuid:47acb00d-7d3f-4be9-86f7-e22d368a6a28","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1236","original_object":"UniProtKB:Q91ZY1"}
{"id":"efb7e126-5a38-4340-9cc7-a0f9e7b0ce67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817433","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:b5b872d7-388c-4ff5-baec-0ddc8b77d0e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1827","original_object":"UniProtKB:P49190"}
{"id":"46c54916-091c-40e6-a590-6debeed57184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6438966","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:74f914e0-b73f-48f1-88de-d0a3557edec1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1886","original_object":"UniProtKB:Q13258"}
{"id":"95c5d080-4427-4879-abbc-a2cd2719995b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:178169","predicate":"biolink:affects","object":"NCBIGene:59340","sources":[{"id":"urn:uuid:99c61a16-3559-4720-a678-87fcbb176e8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1270","original_object":"UniProtKB:Q9H3N8"}
{"id":"affcd00f-68b6-4456-8491-bbd0f67c3e81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QKC82E736Q","predicate":"biolink:affects","object":"NCBIGene:4886","sources":[{"id":"urn:uuid:5b32b8c6-720e-4923-b0bf-6e5a4ec24111","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1528","original_object":"UniProtKB:P25929"}
{"id":"2128577e-852c-46c4-b6d0-a532b6f93ca9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13299","predicate":"biolink:affects","object":"NCBIGene:10927","sources":[{"id":"urn:uuid:eacd61cf-b20c-49ac-8205-7de6a79f3e9f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13299","original_object":"UniProtKB:Q9Y657"}
{"id":"c51d2761-9ecd-4306-b444-a3d00a420da7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85164","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:9d4a978f-0a41-4dbb-9f00-20ebae4d2e33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5936","original_object":"UniProtKB:P17948"}
{"id":"5652c78b-0d5b-47e7-bcbf-46ef61f12575","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92629","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:f7960574-ca46-4085-a86e-77f659d3d894","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:134","original_object":"UniProtKB:P32304"}
{"id":"8f0bd3fe-29d5-4271-9d2e-29cb1b26adb9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:164890","predicate":"biolink:affects","object":"NCBIGene:50834","sources":[{"id":"urn:uuid:bb7d3585-d463-494c-9e36-1563c2b6a671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12424","original_object":"UniProtKB:Q9NYW7"}
{"id":"491761f6-7d9d-4408-9dd7-03e095e5fbc7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1132","predicate":"biolink:affects","object":"NCBIGene:2740","sources":[{"id":"urn:uuid:2a2757ff-65d2-4dbb-8c91-ba380bb20218","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1132","original_object":"UniProtKB:P43220"}
{"id":"2e043d40-75a9-4952-86d9-9e7988343715","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817474","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:9303e281-af14-4ed9-bb00-3432fa833d95","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5357","original_object":"UniProtKB:O08726"}
{"id":"d5daab8e-e1e7-4a8f-8f05-7fd6481c8e46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9164","predicate":"biolink:affects","object":"NCBIGene:2986","sources":[{"id":"urn:uuid:14512137-732e-45b0-a6b5-7a279c9887a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9164","original_object":"UniProtKB:P51841"}
{"id":"68055e1d-0cd0-4b67-9245-35d56577a7b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:28Q8AG0PYL","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:49ed4218-90e6-4d42-9aa9-ff4c796fb667","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12737","original_object":"UniProtKB:P37231"}
{"id":"90df5183-5c64-4cdb-9bc7-779e16efdaf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:29335","sources":[{"id":"urn:uuid:7eefe88e-bf2c-4910-b413-897b2bb12956","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P34975"}
{"id":"bd37be01-b285-4aeb-843b-14299a105bbd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:N673F6W2VH","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:1fd66476-2df9-403a-9a10-a10352dcf793","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6478","original_object":"UniProtKB:P43235"}
{"id":"d0008395-4a5e-4164-a9d2-d121cc7d2c5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755147","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:93b647c2-8b7b-4fc9-a553-41ea29d3ebf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5720","original_object":"UniProtKB:Q8TDV5"}
{"id":"f70767c7-1c3b-43fa-be79-5cb1e20cdeb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3242","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:02313556-ad4a-44e3-a00a-9c0f9e929344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7591","original_object":"UniProtKB:P41145"}
{"id":"b315e8fb-25fb-4047-a443-3477842102ff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3972","predicate":"biolink:affects","object":"UniProtKB:P36544","sources":[{"id":"urn:uuid:3203311d-48b9-4aeb-8af1-d5246ec1b4df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3972","original_object":"UniProtKB:P36544"}
{"id":"82f2a52a-c9e4-41f3-97c5-dbc9b8ee2ff4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:29133","predicate":"biolink:affects","object":"NCBIGene:2905","sources":[{"id":"urn:uuid:ce73b72b-9946-4a01-b099-1cf58ef302ad","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:9052","original_object":"UniProtKB:Q14957"}
{"id":"84ea1e0c-8291-4209-8c6d-3d385e4dc20e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:888023","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:d09e3aa0-a2a5-49a9-8391-5ade7c0b12da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3323","original_object":"UniProtKB:Q14833"}
{"id":"0685a102-d9bb-43e4-8252-c47b9e41ed0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34967","predicate":"biolink:affects","object":"NCBIGene:1268","sources":[{"id":"urn:uuid:2f9150a2-e325-4e72-9740-f1c09e296896","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:743","original_object":"UniProtKB:P21554"}
{"id":"62a76207-9340-4234-96cb-987e272830cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28819","predicate":"biolink:affects","object":"NCBIGene:6579","sources":[{"id":"urn:uuid:e9ff6921-5892-44d6-ac01-b8bec617e421","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4738","original_object":"UniProtKB:P46721"}
{"id":"c72e5212-a049-420d-a1f4-a046f7d1e5a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94506","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:ea4d1ed7-06a7-4867-9945-ba929da55048","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5932","original_object":"UniProtKB:O60674"}
{"id":"6fed5a99-8535-4fcb-90c1-e3c617e0dc45","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9865554","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:67243812-427f-470f-998e-d6165906642d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8497","original_object":"UniProtKB:P25024"}
{"id":"ad11fd2a-6269-4c88-b531-6420834b2c4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393286","predicate":"biolink:affects","object":"NCBIGene:6326","sources":[{"id":"urn:uuid:4a815418-aa9d-4e26-8a94-1f39c12f1ed5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10355","original_object":"UniProtKB:Q99250"}
{"id":"a8fabae7-5691-4ccb-aa1b-e9bb0426d2fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39669","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:575e4182-a869-432a-a0df-e99230192484","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7162","original_object":"UniProtKB:P00374"}
{"id":"28f6d4ae-d80f-40bb-af16-8907106df29e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76612","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:ceee257b-e5d6-46de-93b6-8b404c507868","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6912","original_object":"UniProtKB:Q06187"}
{"id":"e4760237-ba30-4ea7-9f3e-9467dcc8fee9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2208","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:00b8ffe4-b3a6-4678-b196-fed280e23176","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2208","original_object":"UniProtKB:P47901"}
{"id":"268567b3-557e-4c77-9950-10415219ce30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:3750D0U8B5","predicate":"biolink:affects","object":"NCBIGene:27","sources":[{"id":"urn:uuid:79f4e79c-3c80-45e2-a892-967730ba1f1e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9917","original_object":"UniProtKB:P42684"}
{"id":"c43917b4-857f-4fac-bc2a-7df43aa4515c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:1A7Y9MP123","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:2cbb9903-e0cd-4b11-9bbd-833f9d1b3536","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8894","original_object":"UniProtKB:Q9UKV0"}
{"id":"6730171b-5831-48a6-b538-ff24af29ac5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1450","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:f9efa209-058d-4a0c-b7cf-13ca56109a0c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1450","original_object":"UniProtKB:O43193"}
{"id":"2178f049-bd25-470b-9104-dbd8c998f986","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3647","predicate":"biolink:affects","object":"NCBIGene:3362","sources":[{"id":"urn:uuid:6ece6a6f-e6ea-4b22-9916-260f2993484e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:83","original_object":"UniProtKB:P50406"}
{"id":"2be2a615-bbb1-4040-b7da-802b35379491","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11757797","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:1dc4a649-313a-4475-962d-57bcf7a85440","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:292","original_object":"UniProtKB:P20309"}
{"id":"81f8b766-2838-4643-990e-debbadfd0d43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155491009","predicate":"biolink:affects","object":"NCBIGene:3061","sources":[{"id":"urn:uuid:e754c87a-1724-4cf5-b33b-df3264c8ef97","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11447","original_object":"UniProtKB:O43613"}
{"id":"6c213c69-deb4-4a5a-9efa-3df376501615","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11847343","predicate":"biolink:affects","object":"NCBIGene:6789","sources":[{"id":"urn:uuid:bd9fbd82-31d4-4983-b639-157e1e2a9816","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8768","original_object":"UniProtKB:Q13043"}
{"id":"7c73ba06-0c6c-44af-9b02-8b51d3eb5ddb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10104167","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:8a0a1465-9ecb-4cae-8d83-c7bc6fe853ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6937","original_object":"UniProtKB:P08912"}
{"id":"dc73935b-fef1-44fe-aaf0-b3bdca1feaa5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37623","predicate":"biolink:affects","object":"NCBIGene:1880","sources":[{"id":"urn:uuid:43b9ca11-d1ee-47be-9f6f-a4d69def800a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4350","original_object":"UniProtKB:P32249"}
{"id":"9c5b6ec8-6aab-45a4-bfa2-02b4b8691129","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:76649","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:6c4f0c7b-01e3-4ce0-9449-f60fb391ac38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:925","original_object":"UniProtKB:Q60748"}
{"id":"8b98bb29-27bc-4e0f-b517-998501add5d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230338","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:75b216e3-13e9-498b-99d1-c024abc38671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5388","original_object":"UniProtKB:P07550"}
{"id":"0e2dd3af-cb57-472b-b5d8-a1dd3f185fa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156775102","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:802935d1-4fa9-4b58-8844-0904e7b446c3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12143","original_object":"UniProtKB:O60885"}
{"id":"08dd91a8-261f-4cf3-9467-327b9941b5b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2527","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:7edc88f1-6d09-43a7-9637-cc936eb39bf7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2527","original_object":"UniProtKB:P54282"}
{"id":"dc86f7c8-31bd-4ae2-8d33-4b2c32934fee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PG6M3969SG","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:f576e3b7-cb18-4767-972f-f04838ddd835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2906","original_object":"UniProtKB:Q9UBY5"}
{"id":"373d9750-a07b-4e3a-8faf-56d6dbe6a65d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GLI7N28B31","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:8b305a6c-7d74-45e5-933b-fd8297271722","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1903","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"d51c660b-0d01-4f04-bb2e-4672e78c3665","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8723","predicate":"biolink:affects","object":"NCBIGene:29480","sources":[{"id":"urn:uuid:754ec549-239b-4fd6-8527-d078665424b9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8723","original_object":"UniProtKB:P49799"}
{"id":"83503057-ee4c-4a3e-8ac5-315872b0ec98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5855","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:454bb842-08f7-48d7-b414-abf52eb89abd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2713","original_object":"UniProtKB:Q7Z2H8"}
{"id":"c873705a-cb66-49b6-89b6-1c5baf05b2e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25195496","predicate":"biolink:affects","object":"NCBIGene:6256","sources":[{"id":"urn:uuid:fe4ed564-db48-4536-a3aa-80b83845640c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8904","original_object":"UniProtKB:P19793"}
{"id":"d9ca59fb-c6b7-4ba0-bfd2-5e5365baf04d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64114","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:d3010fdb-df16-4b67-9347-94c59fcae163","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:14","original_object":"UniProtKB:P28222"}
{"id":"f68ae941-3b95-4f49-a574-3fd217b538b7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9774","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:add5e946-774c-48a7-81a6-fe188bb50cc6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2294","original_object":"UniProtKB:Q9H2S1"}
{"id":"6c072bb4-a9b1-458d-852c-2fb5bd96b3a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:2917","sources":[{"id":"urn:uuid:fdae4f9d-d7c7-4b5b-859d-24a681555d6e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:Q14831"}
{"id":"a82173b0-c07d-432e-97c7-81e0f2c3ca6b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188612","predicate":"biolink:affects","object":"NCBIGene:3066","sources":[{"id":"urn:uuid:9ef4e8fc-eeec-44d8-86e0-b820da722f78","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7916","original_object":"UniProtKB:Q92769"}
{"id":"61f14cfd-a7f9-472d-9bc6-89c11a44d913","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3286","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:7969f259-ec2b-4317-80af-bedb3f1fa4a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:37","original_object":"UniProtKB:P35348"}
{"id":"5abbdfb0-c4b2-46ba-828b-3b703a57408a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PV6YEC8983","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:11176156-457d-4139-b92e-2a230093c7d1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4166","original_object":"UniProtKB:P42263"}
{"id":"d37e4107-a206-45dd-8617-288b70fdfbb3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:695","predicate":"biolink:affects","object":"NCBIGene:84348","sources":[{"id":"urn:uuid:9a62caf6-9c1d-4b23-a0d2-3792604db599","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:695","original_object":"UniProtKB:O89039"}
{"id":"79f8d02d-6ffc-408c-9660-eca319078113","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9911652","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:8bc9419c-a2a7-4a85-8b57-20dbe4dbe570","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8203","original_object":"UniProtKB:P11802"}
{"id":"612ff697-f5c8-475d-8f86-2368038a77a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230494","predicate":"biolink:affects","object":"NCBIGene:8737","sources":[{"id":"urn:uuid:e4e16ab9-9b37-4a9e-8262-318106299ba8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11274","original_object":"UniProtKB:Q13546"}
{"id":"86efe5f9-54e8-4e9a-9673-c6cee6051670","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:81a8321f-e47b-450f-93bc-4e588b0dae1f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P14416"}
{"id":"d088a4c1-a566-4f3d-8e41-ed7cb1941b89","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135390649","predicate":"biolink:affects","object":"NCBIGene:9113","sources":[{"id":"urn:uuid:60d6a7f0-0d69-4429-9280-89c946b52f10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12662","original_object":"UniProtKB:O95835"}
{"id":"217c3eb5-99e2-4c69-9fdf-eca7d6d056d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2186","predicate":"biolink:affects","object":"UniProtKB:P48974","sources":[{"id":"urn:uuid:0ba58e8b-53e0-4794-b020-7c88d5a17be5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2186","original_object":"UniProtKB:P48974"}
{"id":"3b79ba3c-4678-4800-b415-7faeccd8abdb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42944","predicate":"biolink:affects","object":"NCBIGene:43","sources":[{"id":"urn:uuid:08a6c11c-8a2b-4a65-b157-50cd8b9b80a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6693","original_object":"UniProtKB:P22303"}
{"id":"498ce300-de72-4fc5-b0a5-c2e447627557","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91418","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:5f1f1c60-b7bb-4a52-a0ff-2fded5f73ab6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5679","original_object":"UniProtKB:P35916"}
{"id":"ebd0aec6-1e37-46ed-a269-eddf0a3675e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:6f19a62b-5a47-4f87-9f70-782641e28a01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P35348"}
{"id":"e99db385-e182-417a-a775-0e6f3d8f9b0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:37659","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:f89c3b32-4f94-4b33-9fd4-83637345c8f5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3306","original_object":"UniProtKB:Q8TDU6"}
{"id":"3a4b0bc5-2bbf-414c-ae08-18e4d94824c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:126456406","predicate":"biolink:affects","object":"NCBIGene:186","sources":[{"id":"urn:uuid:e48a5171-fc2a-4e43-ac55-f10e3def513c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11931","original_object":"UniProtKB:P50052"}
{"id":"3e8b5282-d394-41cf-a795-bf8b06e96e7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L08J2O299M","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:289a8144-2a80-495f-9aef-27947b715c80","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7794","original_object":"UniProtKB:P48736"}
{"id":"55f8584b-81cb-442e-b290-63f01d186df1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4382","predicate":"biolink:affects","object":"NCBIGene:1232","sources":[{"id":"urn:uuid:27827238-e32a-4601-8ecd-5c46d31202ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4382","original_object":"UniProtKB:P51677"}
{"id":"b7c5c3e6-6f15-42e6-9b02-a7b2da5cc64a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:950368","predicate":"biolink:affects","object":"NCBIGene:7345","sources":[{"id":"urn:uuid:34f57c3f-4fc4-464f-9932-ebc77fd2749c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8661","original_object":"UniProtKB:P09936"}
{"id":"ab6f16c2-3475-4320-ab58-904d108725d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947039","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:a2fb5d99-217d-4eba-acb7-0136653e909d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3016","original_object":"UniProtKB:P51639"}
{"id":"1c064066-1bac-456d-87b5-dbbe25578aad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135859","predicate":"biolink:affects","object":"NCBIGene:8912","sources":[{"id":"urn:uuid:1e6d544f-a9b7-4ed4-b70b-44e9ae8c2f49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:12565","original_object":"UniProtKB:O95180"}
{"id":"4ce79c11-f013-461a-9dfa-6721f97602cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T1V3OH20HG","predicate":"biolink:affects","object":"NCBIGene:5027","sources":[{"id":"urn:uuid:830517fc-b575-444b-81f9-0316c9036152","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"allosteric_modulation","original_subject":"GTOPDB:10504","original_object":"UniProtKB:Q99572"}
{"id":"2f63de37-90e7-4a0c-ac41-c78f9525bab3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32076","predicate":"biolink:affects","object":"NCBIGene:3785","sources":[{"id":"urn:uuid:14fd0f02-1f1e-4efd-82a0-3d4ace5207aa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2597","original_object":"UniProtKB:O43526"}
{"id":"d55c8c8d-3818-4df8-9d37-ec53057f07c1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51098","predicate":"biolink:affects","object":"NCBIGene:3791","sources":[{"id":"urn:uuid:b378d6d1-0753-4687-9761-f23a8f45a7d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5660","original_object":"UniProtKB:P35968"}
{"id":"b15e3a28-d0f6-4886-9f81-56afa3f4ced1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131184","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:48688e9e-f67b-42a0-86f9-fa855a2e627d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2433","original_object":"UniProtKB:Q9UL62"}
{"id":"a231ccbf-8a4a-4ca9-b202-1dd05ff3b69b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:189802","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:4b2ac55b-e890-48b3-aa73-c2e5ed077c8d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12994","original_object":"UniProtKB:Q99685"}
{"id":"a4582bef-30d9-471c-a145-79857310cdeb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34808","predicate":"biolink:affects","object":"NCBIGene:2897","sources":[{"id":"urn:uuid:da414cb5-da47-47a1-93ab-7e2701334197","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4247","original_object":"UniProtKB:P39086"}
{"id":"a89737ab-3fe8-48d2-a307-1847afabc30d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:38RL9AE51Q","predicate":"biolink:affects","object":"NCBIGene:3454","sources":[{"id":"urn:uuid:bae98821-5a96-451c-8cd3-cfc69a19c83a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8258","original_object":"UniProtKB:P17181"}
{"id":"b0079e10-416a-4cd3-ab0d-291e97ec987e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13809","predicate":"biolink:affects","object":"NCBIGene:2264","sources":[{"id":"urn:uuid:5799ced1-2e7d-4efd-812c-f239837fd919","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13809","original_object":"UniProtKB:P22455"}
{"id":"35db860c-e18a-4ac1-865f-c20bc8b9971f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817484","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:bf7f55cd-ae58-4aff-8126-5cb660ee960a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6117","original_object":"UniProtKB:Q62805"}
{"id":"3453c5ca-134e-4e61-892a-b60ae08e7062","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:4017","predicate":"biolink:affects","object":"NCBIGene:64106","sources":[{"id":"urn:uuid:75ec8877-917a-41b3-99de-659fd4d0fe1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4017","original_object":"UniProtKB:Q9GZQ6"}
{"id":"3e540c90-38c6-40b4-867d-f4dc57ca9efe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4046493","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:33be2c65-37e7-4681-9572-adfbc846de2d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3280","original_object":"UniProtKB:P30543"}
{"id":"8437e06f-0875-44d8-8f40-6b38d7539a04","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:15521397","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:d84f30e4-90ad-4a6c-9a3f-1dc0ffc650ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2787","original_object":"UniProtKB:P11473"}
{"id":"622261ec-e29a-4e55-86c3-698cddcd0370","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A7CGH459FN","predicate":"biolink:affects","object":"NCBIGene:6530","sources":[{"id":"urn:uuid:5dd403b5-aabc-467c-8615-63b554362a39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12766","original_object":"UniProtKB:P23975"}
{"id":"c3a2a8c1-5e45-46e4-b517-367aa87e2e4c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90721","predicate":"biolink:affects","object":"NCBIGene:4843","sources":[{"id":"urn:uuid:63eda52e-fbf9-4ef8-9d37-3b46579f2c8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5102","original_object":"UniProtKB:P35228"}
{"id":"5deea8f3-67ce-44ab-a3e8-a5e2339f4050","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:438","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:517c12f5-f958-4268-94a9-aa723e254a8f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:438","original_object":"UniProtKB:P29275"}
{"id":"131d6228-95d0-4a37-82f0-1f9e37f992da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:40303","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:677e6f26-8eab-49f8-a2b2-0638eeb3c924","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2739","original_object":"UniProtKB:P51639"}
{"id":"d654db11-0bee-4185-b64e-6ac32c4ab5a5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93701","predicate":"biolink:affects","object":"NCBIGene:553","sources":[{"id":"urn:uuid:54570aeb-a120-4512-bfd4-6375b62c2014","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2200","original_object":"UniProtKB:P47901"}
{"id":"327862e0-61a7-447a-b853-a7e42d074835","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28748","predicate":"biolink:affects","object":"NCBIGene:7153","sources":[{"id":"urn:uuid:b5cdd7ee-1074-4499-b2ea-3cfe6af93585","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7069","original_object":"UniProtKB:P11388"}
{"id":"dc8ce542-dc55-4514-a57d-44dba774c1d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:49868","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:d89258a6-5efe-4a9c-b11e-9e11bd1410ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5666","original_object":"UniProtKB:O60885"}
{"id":"f537e518-9b30-4f03-a40f-e77650738cce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56846694","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:663c0b2e-accf-4e8b-886b-1beb55a53430","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11437","original_object":"UniProtKB:P41594"}
{"id":"485d7c7c-88f3-4352-bc75-5b36c486b21b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OSZ0E9DGOJ","predicate":"biolink:affects","object":"NCBIGene:2559","sources":[{"id":"urn:uuid:33b9f455-48ee-47e3-b94f-39712936b0dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4146","original_object":"UniProtKB:Q16445"}
{"id":"445de82f-33b7-48b1-a572-ca9644f9fb71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63638","predicate":"biolink:affects","object":"NCBIGene:18","sources":[{"id":"urn:uuid:80553764-8917-4170-895e-09d2715757d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4821","original_object":"UniProtKB:P80404"}
{"id":"bb9994a6-2583-400f-a212-08ad516d8dcf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3660","predicate":"biolink:affects","object":"NCBIGene:2833","sources":[{"id":"urn:uuid:26622b99-e15f-43ce-b7e7-52d22d382de6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3660","original_object":"UniProtKB:P49682"}
{"id":"49cf73d9-448e-459a-8491-4ee65c1c8132","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134457640","predicate":"biolink:affects","object":"NCBIGene:9201","sources":[{"id":"urn:uuid:12bca605-216f-4914-9503-dbd872306e2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11114","original_object":"UniProtKB:O15075"}
{"id":"c1e53531-353a-494e-9212-29d0eae320c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:90200922","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:dea32017-b993-4151-a7db-d6a10a39afe7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12165","original_object":"UniProtKB:P20309"}
{"id":"9e170985-f363-49d8-9ee7-812e7e415c44","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16757525","predicate":"biolink:affects","object":"NCBIGene:1017","sources":[{"id":"urn:uuid:289b783a-a88d-4e73-a6ae-2eea95abf93a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8114","original_object":"UniProtKB:P24941"}
{"id":"5b1687e7-9d1a-4ffe-a976-ee14fe50f65a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15555","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:23414736-398c-48e0-b3eb-317d577803f4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1881","original_object":"UniProtKB:Q13258"}
{"id":"5c012d25-d998-483a-bbe7-f7df897c5474","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519693","predicate":"biolink:affects","object":"NCBIGene:640","sources":[{"id":"urn:uuid:2ada6f03-f5b4-45b0-afb1-ceda0e5f6ff5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8148","original_object":"UniProtKB:P51451"}
{"id":"8416fb40-3e32-488d-b1c1-e1579f3c3d9c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135359","predicate":"biolink:affects","object":"NCBIGene:153","sources":[{"id":"urn:uuid:5615d6cc-a047-4939-b9fd-d378e62f615e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:534","original_object":"UniProtKB:P08588"}
{"id":"aa8d8fb0-23b5-4b22-b579-7af53401172c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:135274950","predicate":"biolink:affects","object":"NCBIGene:208","sources":[{"id":"urn:uuid:e43666cd-d5e9-4d3e-88b9-0df539e9c835","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12722","original_object":"UniProtKB:P31751"}
{"id":"f9bde89c-a663-44f4-97b7-56a759379c4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173098","predicate":"biolink:affects","object":"NCBIGene:246","sources":[{"id":"urn:uuid:e985ef2e-b356-41c8-9a24-7a4239bee838","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11390","original_object":"UniProtKB:P16050"}
{"id":"e12fbc89-46a9-4336-9ee6-456755ab78bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755176","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:4b5f2a9a-dcad-4dc9-86e0-02c5e74b35e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6148","original_object":"UniProtKB:Q9H244"}
{"id":"dea37709-4dcc-4b1f-88da-583cbd56d60c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:156065422","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:349eafbe-13a8-46ec-ab92-40ccd9fdabaf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13224","original_object":"UniProtKB:P35346"}
{"id":"f0053f4b-3f7a-4a5f-89cd-994fc8fcc77f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5P57R7IR6J","predicate":"biolink:affects","object":"NCBIGene:20606","sources":[{"id":"urn:uuid:6f6bf8c4-8deb-4678-baf3-3757a7581a49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2051","original_object":"UniProtKB:P30875"}
{"id":"a53a17ea-12a3-4f42-b998-a671b8656578","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FQK825B5DX","predicate":"biolink:affects","object":"NCBIGene:2263","sources":[{"id":"urn:uuid:3940efac-0528-40af-9004-760e7a86581b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8862","original_object":"UniProtKB:P21802"}
{"id":"667a918b-0ef2-47c7-b86c-b95500bdc95f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93613","predicate":"biolink:affects","object":"NCBIGene:348980","sources":[{"id":"urn:uuid:65ef02f4-1ae8-4bd8-a54e-4169ace6a16c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2358","original_object":"UniProtKB:O60741"}
{"id":"4528ffe0-1cc7-4f79-8d4f-b2ca5561cbff","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3374","predicate":"biolink:affects","object":"NCBIGene:193034","sources":[{"id":"urn:uuid:ba31e6a7-077f-46bf-9e61-6d3eb2059748","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2486","original_object":"UniProtKB:Q704Y3"}
{"id":"e9af2011-dfa1-4725-ab66-a51865f8049f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:44296","predicate":"biolink:affects","object":"NCBIGene:56479","sources":[{"id":"urn:uuid:9d3465a7-e02b-4447-b25b-ed449a80d2ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2343","original_object":"UniProtKB:Q9NR82"}
{"id":"3bc4e79a-cbde-483a-986b-50c75eff86b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71734765","predicate":"biolink:affects","object":"NCBIGene:5797","sources":[{"id":"urn:uuid:ac0aba94-29a8-4350-9083-2c912e47f07c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8856","original_object":"UniProtKB:P28827"}
{"id":"e6449685-67c6-4381-9799-8585a8096337","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KT54N4CC67","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:40f028f5-32fc-4b1b-8c2b-cbd1df38069f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:160","original_object":"UniProtKB:P41595"}
{"id":"ec0b1cce-e036-498c-b81a-8518a09d14f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:VQ7NU11KRM","predicate":"biolink:affects","object":"NCBIGene:10013","sources":[{"id":"urn:uuid:05e70234-6c49-48a7-a966-e2b4cae7921c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12269","original_object":"UniProtKB:Q9UBN7"}
{"id":"a2119ae0-759d-4394-9a20-503804353c15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3441","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:38d53c25-49f1-46ed-8a25-b2763ee82214","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:551","original_object":"UniProtKB:P13945"}
{"id":"f8b730e6-a522-4c67-a5ec-8467e7255114","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2726776","predicate":"biolink:affects","object":"NCBIGene:321019","sources":[{"id":"urn:uuid:5704703a-e6cc-47a7-bcfe-2c7b5fe58f5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13051","original_object":"UniProtKB:Q3U6B2"}
{"id":"f97229c1-7a95-4371-aa67-f793cde5a8c0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2261","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:993e6d37-ea5c-4cbd-abd9-7e37576687f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2261","original_object":"UniProtKB:P41587"}
{"id":"ccdfc319-8b51-4d14-82c4-da8cc01effb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:9472","predicate":"biolink:affects","object":"NCBIGene:65024","sources":[{"id":"urn:uuid:b97ee8f5-a0c0-454a-9bbc-caa127374c67","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9472","original_object":"UniProtKB:P43144"}
{"id":"72c01a79-42a2-41a4-a015-6dd6247c8377","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:RA72G28VE9","predicate":"biolink:affects","object":"NCBIGene:5999","sources":[{"id":"urn:uuid:d5cb0bb8-76df-44d5-b618-1b0268693212","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7784","original_object":"UniProtKB:P49798"}
{"id":"aae4bfc0-1cfc-42d5-869a-2f35a2f29baf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:75251","predicate":"biolink:affects","object":"NCBIGene:3480","sources":[{"id":"urn:uuid:0eb248b7-74d5-445b-a43d-4c3cc2afd8c8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7873","original_object":"UniProtKB:P08069"}
{"id":"40e54f2f-cc22-4710-99d2-05b22321536e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:73282","predicate":"biolink:affects","object":"NCBIGene:29290","sources":[{"id":"urn:uuid:e20d3079-ac1d-4af7-b268-0f7def3a84d0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:386","original_object":"UniProtKB:P25099"}
{"id":"d64e2fff-8553-4ba7-9163-49299de21bad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92842","predicate":"biolink:affects","object":"NCBIGene:2030","sources":[{"id":"urn:uuid:5bd4a9b4-5fb8-46b0-8204-fbb7456e348f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4717","original_object":"UniProtKB:Q99808"}
{"id":"8e47d822-bc05-4536-b0b0-eed3dde9ca40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51368","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:8e284f76-89d3-4351-9e96-9a48bd894990","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9868","original_object":"UniProtKB:P08913"}
{"id":"19070cd7-4d14-4621-a569-4d87cbc1e95d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13886","predicate":"biolink:affects","object":"NCBIGene:5133","sources":[{"id":"urn:uuid:f94a9e22-4bae-4b22-864e-b103719c8a84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:13886","original_object":"UniProtKB:Q15116"}
{"id":"748c2ba7-8065-46ec-bbcb-17f593f1c87e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:146624881","predicate":"biolink:affects","object":"NCBIGene:3845","sources":[{"id":"urn:uuid:ffa3bdfa-659f-42e8-8dc4-5e0736decb54","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11963","original_object":"UniProtKB:P01116"}
{"id":"c3731b41-3144-49b6-b23c-094663dc1e2e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:23043","sources":[{"id":"urn:uuid:ca24af7c-071f-4197-bd78-bd569a805ed1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:Q9UKE5"}
{"id":"d8363b85-1c06-4b95-8b69-bfad6afe8996","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131351","predicate":"biolink:affects","object":"NCBIGene:136","sources":[{"id":"urn:uuid:91c69f5f-6294-499e-992b-19070fd72554","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:384","original_object":"UniProtKB:P29275"}
{"id":"c2f1723e-fea7-44e5-a953-df31b7e90d84","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699441","predicate":"biolink:affects","object":"NCBIGene:9891","sources":[{"id":"urn:uuid:7f9b661b-8102-40f3-ad0c-7a1723e2966b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11085","original_object":"UniProtKB:O60285"}
{"id":"57619498-ba1c-438b-a463-40db469cae86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35020","predicate":"biolink:affects","object":"NCBIGene:50840","sources":[{"id":"urn:uuid:70c9ee95-dd0a-4a10-a3f0-d7868bd35ac4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12450","original_object":"UniProtKB:Q9NYV8"}
{"id":"96b1788e-4e16-457f-8ac4-34bfd60888ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:4A3702A96F","predicate":"biolink:affects","object":"NCBIGene:13488","sources":[{"id":"urn:uuid:52b93fab-271f-4306-ae19-34482c38d3a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10506","original_object":"UniProtKB:Q61616"}
{"id":"20e11de1-58db-456f-b4ae-19d6d347e275","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:164886635","predicate":"biolink:affects","object":"NCBIGene:5294","sources":[{"id":"urn:uuid:c669b436-c5a0-4790-98c3-67cf0a02c15e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12062","original_object":"UniProtKB:P48736"}
{"id":"6f670365-dd6f-4c85-bbee-bb1a6f52f314","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:174159","predicate":"biolink:affects","object":"NCBIGene:2033","sources":[{"id":"urn:uuid:c5fcf5cb-da97-4b36-b6e3-b3bea240d5d3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7001","original_object":"UniProtKB:Q09472"}
{"id":"281663a5-9c1a-42d2-86c0-4b8d0e7f5b65","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91330","predicate":"biolink:affects","object":"NCBIGene:472","sources":[{"id":"urn:uuid:874cdc12-7b92-4334-b2c1-0bb4e7eb5f5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9359","original_object":"UniProtKB:Q13315"}
{"id":"52e8585c-8bfd-4841-9a14-707bcf4f4e77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32020","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:c452bff7-e3eb-4c24-98fb-b38f1f82f036","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3035","original_object":"UniProtKB:P51639"}
{"id":"50a0f63f-8aec-4e46-9742-777e47b903b1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947075","predicate":"biolink:affects","object":"NCBIGene:13609","sources":[{"id":"urn:uuid:0c6262f4-2be1-4c6c-a290-8fa237320a5b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2923","original_object":"UniProtKB:O08530"}
{"id":"b1acfadb-59cf-4610-bd63-2176c6aeab39","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5RV7T5BNMG","predicate":"biolink:affects","object":"NCBIGene:3269","sources":[{"id":"urn:uuid:56b66252-25f4-4b00-a79f-5c9bbf5b8aae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8984","original_object":"UniProtKB:P35367"}
{"id":"b3042315-66d7-4e03-ae0f-e58cd99e190b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93269","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:1d950c9c-853a-4c36-9b8f-860dda1181e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:449","original_object":"UniProtKB:P29274"}
{"id":"4c970c08-8cd8-4175-ace2-a04479a225e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12103","predicate":"biolink:affects","object":"NCBIGene:953","sources":[{"id":"urn:uuid:d80a90b2-a5f8-442a-816e-00e88a84428f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12103","original_object":"UniProtKB:P49961"}
{"id":"84d078b0-3289-4bce-99b1-07db6d8ce429","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:70735","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:1f63417d-462a-416b-8c4b-10fb89d31080","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7461","original_object":"UniProtKB:P08913"}
{"id":"aaf4b10d-eba7-445a-b525-829405807ec8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8212","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:529db5db-c55a-46a0-bdd5-1ffa261724dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:90","original_object":"UniProtKB:P32305"}
{"id":"fb516e12-88e5-4dac-bdc9-32bb80db33be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:J1I0P6WT7T","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:c8036761-f9c5-4302-90cb-9e259c7d48f0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8699","original_object":"UniProtKB:P56817"}
{"id":"d37701a0-8e23-4657-a503-6e0bf1d2b4dd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:94187","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:d67b8450-4c06-45a5-a960-5bfd88528986","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7490","original_object":"UniProtKB:Q9UQL6"}
{"id":"012ac67e-d6df-4d1a-a86f-166deffe804a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:151183","predicate":"biolink:affects","object":"NCBIGene:5465","sources":[{"id":"urn:uuid:d3567f1c-87e6-47bd-a826-05daf66c119f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2677","original_object":"UniProtKB:Q07869"}
{"id":"1ef11eec-7867-4259-96b2-99e2cae985c8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801162","predicate":"biolink:affects","object":"NCBIGene:81672","sources":[{"id":"urn:uuid:5cc2a270-b88d-42cc-9e4a-961ceef8d94c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9703","original_object":"UniProtKB:P35400"}
{"id":"bf4ffb94-921e-4b67-9bb4-9170f366df15","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2434","predicate":"biolink:affects","object":"NCBIGene:58800","sources":[{"id":"urn:uuid:81d963c9-263d-48ba-98c0-8205352cfd05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2434","original_object":"UniProtKB:Q923J1"}
{"id":"7d2b2932-0fe1-4374-941d-8f410309e1b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8Y1PJ3VG81","predicate":"biolink:affects","object":"NCBIGene:56749","sources":[{"id":"urn:uuid:bda9cc6e-67ba-49f8-9a6a-5f59253e1a05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9860","original_object":"UniProtKB:O35435"}
{"id":"377b0365-dc81-49fb-9053-30592249df1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95014","predicate":"biolink:affects","object":"NCBIGene:47","sources":[{"id":"urn:uuid:ce5c3e43-fe04-479a-8456-5700478aa9eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12855","original_object":"UniProtKB:P53396"}
{"id":"1bb658eb-cb66-4e77-88f1-40087d4a9a6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:15551","sources":[{"id":"urn:uuid:f7da4275-a426-45de-a269-1c93efd8b34b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P28334"}
{"id":"b9e7c4fa-ae9b-45fa-b8ba-2e2819412915","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755184","predicate":"biolink:affects","object":"NCBIGene:260319","sources":[{"id":"urn:uuid:95ef9167-0d78-41bb-bfd6-73b546cbd819","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6192","original_object":"UniProtKB:Q8K418"}
{"id":"9aeeb934-cde2-4825-96cb-416d7e354ab0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1454","predicate":"biolink:affects","object":"NCBIGene:2862","sources":[{"id":"urn:uuid:388a0171-552f-4986-9ef9-e697595f4084","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1454","original_object":"UniProtKB:O43193"}
{"id":"a9c7f30c-39ed-41a9-83fd-d8f2c17d384e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O4BT6C02M2","predicate":"biolink:affects","object":"NCBIGene:5693","sources":[{"id":"urn:uuid:6fb1d17f-6a50-4625-938a-456db227ea3e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10409","original_object":"UniProtKB:P28074"}
{"id":"44f98ec7-e059-4d82-9a8f-d605951b83b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TX3R141LEP","predicate":"biolink:affects","object":"UniProtKB:Q02294","sources":[{"id":"urn:uuid:9220ed97-a517-4896-91c5-de80d8b2cdce","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7765","original_object":"UniProtKB:Q02294"}
{"id":"62971954-d631-41d1-afb1-ba5e22e7d3a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4903","predicate":"biolink:affects","object":"NCBIGene:2099","sources":[{"id":"urn:uuid:3e3ed120-f67f-477e-af96-710276b47c8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7071","original_object":"UniProtKB:P03372"}
{"id":"e041a429-90d3-40a1-bcd1-d9a4db2b171e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:132082","predicate":"biolink:affects","object":"NCBIGene:9734","sources":[{"id":"urn:uuid:b5007696-93dd-4ceb-9aba-1d01476d1fb6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7007","original_object":"UniProtKB:Q9UKV0"}
{"id":"c08f8467-59bd-4bf2-9344-44f538685d8d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145373","predicate":"biolink:affects","object":"NCBIGene:2321","sources":[{"id":"urn:uuid:1e8f75cf-00ca-47d2-8bdf-5cddeb069742","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8710","original_object":"UniProtKB:P17948"}
{"id":"f41ffd6b-67e8-48e3-9b6f-4bc1b71677fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8871","predicate":"biolink:affects","object":"NCBIGene:147","sources":[{"id":"urn:uuid:6924f065-ec55-44b6-90c7-24a3ddfe4bc3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:96","original_object":"UniProtKB:P35368"}
{"id":"2f040803-e1f9-46e6-87ba-b7b6765a4fb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:80266","predicate":"biolink:affects","object":"NCBIGene:4987","sources":[{"id":"urn:uuid:06c621e5-f8a2-4308-b12b-b3e10f7d42b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1681","original_object":"UniProtKB:P41146"}
{"id":"d299766b-e128-4c29-8f11-a28f0b81f1e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44381715","predicate":"biolink:affects","object":"NCBIGene:9520","sources":[{"id":"urn:uuid:55331041-ff64-4969-a408-290818e614d4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8671","original_object":"UniProtKB:P55786"}
{"id":"40fe99da-e0cc-4ddc-98f7-c7fdbbcd543b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17066","predicate":"biolink:affects","object":"NCBIGene:80885","sources":[{"id":"urn:uuid:430a5891-5800-4cb0-9ba0-aa73a05fda48","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1593","original_object":"UniProtKB:Q9EP66"}
{"id":"4a7aa2c9-449d-4af0-bef2-97a85f90e6a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2028","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:b46c22ef-c50a-478b-ad40-8785daadcc56","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2028","original_object":"UniProtKB:P30874"}
{"id":"77e6b8b1-f0e4-47c0-adfb-0667b4de04ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:918","predicate":"biolink:affects","object":"NCBIGene:12922","sources":[{"id":"urn:uuid:4daa0d15-30e3-4958-88e8-7560bcf0cba3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:918","original_object":"UniProtKB:Q60748"}
{"id":"786736a4-f7d1-4a15-b173-1fb08a32c5fe","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F8GU4PSP29","predicate":"biolink:affects","object":"NCBIGene:5137","sources":[{"id":"urn:uuid:f3777d4f-4d23-4e4a-8c1e-b5d56fde084e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5270","original_object":"UniProtKB:Q14123"}
{"id":"d71aa2a8-a2af-4ece-9fa7-0d8f73daa1dc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1491","predicate":"biolink:affects","object":"NCBIGene:387129","sources":[{"id":"urn:uuid:71244b28-9ba0-4498-bf22-41b249a78c39","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1491","original_object":"UniProtKB:Q6W5P4"}
{"id":"6052b7bf-03e1-4a4b-9c88-610e2f4b61fc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311232","predicate":"biolink:affects","object":"UniProtKB:P30557","sources":[{"id":"urn:uuid:0a717d9b-56c1-4520-9ccf-9b17b79c645b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5824","original_object":"UniProtKB:P30557"}
{"id":"d7bbfb13-bd0b-40b8-bc50-a589e6e11705","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64069","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:e5be70f6-216b-4937-86a7-7fc6ff64833e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:130","original_object":"UniProtKB:P28223"}
{"id":"af6d09b2-0369-4b25-bfec-52711bae57db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6620134","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:53e08868-87a8-41d8-8582-d6d52c40983a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8978","original_object":"UniProtKB:P42336"}
{"id":"8cb70d50-574f-4db0-9ca4-556d68f0fb40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL445816","predicate":"biolink:affects","object":"NCBIGene:25342","sources":[{"id":"urn:uuid:f2ba601f-70cc-4ec4-b6db-4d1a70b7cd09","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2194","original_object":"UniProtKB:P70536"}
{"id":"51adf6d8-fbe6-4ed0-a598-c0e5bb1a9cd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231618","predicate":"biolink:affects","object":"NCBIGene:2104","sources":[{"id":"urn:uuid:62f6b542-19e1-47d4-8130-6ee108c2f090","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2817","original_object":"UniProtKB:P62508"}
{"id":"2779968a-54bd-4466-93ac-314b59548193","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AM9K4SZ3XK","predicate":"biolink:affects","object":"NCBIGene:5603","sources":[{"id":"urn:uuid:2891ad98-6100-4421-baf1-310057a6299d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12122","original_object":"UniProtKB:O15264"}
{"id":"bf400676-4ace-42e3-85a9-daed2b18efe5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10241837","predicate":"biolink:affects","object":"NCBIGene:383","sources":[{"id":"urn:uuid:1922524a-cc1a-4343-be81-f05c00b3b2a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8806","original_object":"UniProtKB:P05089"}
{"id":"929a4be1-66e0-41b7-86e1-6de56d453fd3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17474","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:5dfdf568-e7ae-4a34-893c-90ea942ead7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4749","original_object":"UniProtKB:Q9Y6L6"}
{"id":"c257899e-1f9c-4ca3-9e9e-adcf7201d0e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817480","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:45911be1-0ea5-4ef2-8615-a3b63eb874a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6091","original_object":"UniProtKB:Q62805"}
{"id":"61ba56f4-b76c-4ffc-9da5-e508b857caba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231702","predicate":"biolink:affects","object":"NCBIGene:6714","sources":[{"id":"urn:uuid:02b1f93c-47ac-45e6-9dd0-d525beaadd1b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7957","original_object":"UniProtKB:P12931"}
{"id":"8df20288-aadc-403f-ac6f-0b2b7770297a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947038","predicate":"biolink:affects","object":"NCBIGene:3156","sources":[{"id":"urn:uuid:3874bd96-9129-49b2-8b26-454632646833","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3015","original_object":"UniProtKB:P04035"}
{"id":"084c5a6f-f030-4df5-8235-102d845e1715","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231413","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:33898b81-4cf5-4d3e-a286-f2a0ad5ed324","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9226","original_object":"UniProtKB:P49286"}
{"id":"2eee523f-0819-4200-8bfe-3054bde1dc98","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5613","predicate":"biolink:affects","object":"NCBIGene:29595","sources":[{"id":"urn:uuid:264483eb-ee67-4857-9a18-9f6c1849894d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:86","original_object":"UniProtKB:P14842"}
{"id":"77a1df43-fd9b-4700-a432-7dafa16e7276","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:173208","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:105bef40-265c-457a-bca9-423ebbb13b25","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1893","original_object":"UniProtKB:P43117"}
{"id":"d3a666d3-5cd1-44da-92f5-82474e0e2294","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:72603","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:a45244db-d622-47e6-8d80-71dce3cf26b4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1900","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"3ba61740-d91f-485c-9df2-52458d10d157","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28177","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:945c478c-9bd0-43f5-a08a-1b644a5ff63e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:413","original_object":"UniProtKB:P30543"}
{"id":"5d9d0889-47e3-4c87-88db-548ef832b20e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:78319072","predicate":"biolink:affects","object":"NCBIGene:497009","sources":[{"id":"urn:uuid:d374a79a-4878-49ef-b0f7-7dbade9e1035","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"irreversible_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9178","original_object":"UniProtKB:Q5KTC7"}
{"id":"08ff3de0-a32f-474b-9930-caa27309234c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91585","predicate":"biolink:affects","object":"NCBIGene:154","sources":[{"id":"urn:uuid:1f247680-3796-49dd-98ea-23047d3d5539","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3464","original_object":"UniProtKB:P07550"}
{"id":"6db6f78b-db76-49bf-aea4-b489133db316","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38940","predicate":"biolink:affects","object":"NCBIGene:3815","sources":[{"id":"urn:uuid:018b7d65-99c5-4c1c-b8b7-f352810f2175","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5713","original_object":"UniProtKB:P10721"}
{"id":"2856f073-8771-4237-ad69-e88b7dac0b00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:188072","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:7189bb70-80ab-4333-9083-635e49f4a251","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:67","original_object":"UniProtKB:P28221"}
{"id":"1193eac8-963c-43ff-81fe-7dda9c794695","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M43ZDU10DD","predicate":"biolink:affects","object":"NCBIGene:116509","sources":[{"id":"urn:uuid:244cf8b9-db42-41ec-9124-221eaebbf243","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12110","original_object":"UniProtKB:P28572"}
{"id":"a449b66f-4c74-4dd1-8cf1-1924825d7213","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L9QRA71834","predicate":"biolink:affects","object":"NCBIGene:80036","sources":[{"id":"urn:uuid:a6845f8f-e644-4289-b8a2-917fd1db1dd9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2454","original_object":"UniProtKB:Q9HCF6"}
{"id":"19bcfee9-385c-4009-a35d-687dbb0d9034","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755161","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:7cf845d5-bcf7-43f7-aeac-83ed9d266102","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5834","original_object":"UniProtKB:P21462"}
{"id":"8597c430-3532-4392-8d8c-9ad0167c0be3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44559101","predicate":"biolink:affects","object":"NCBIGene:3360","sources":[{"id":"urn:uuid:72a5866a-e5f7-4ff8-8f1f-368c76f13463","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:259","original_object":"UniProtKB:Q13639"}
{"id":"c901af86-773a-4438-96b4-650e1d512453","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2029","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:ee10b995-8fa8-4436-92e9-801a6724c578","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2029","original_object":"UniProtKB:O08858"}
{"id":"9be0a0ad-0e4f-4ea9-96ae-3f3be140bb06","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:53232451","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:522a28aa-b3fc-4e4a-8ec7-52a7cb3b2828","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8123","original_object":"UniProtKB:P04629"}
{"id":"d83042ec-ff24-4d4a-bb9c-003d3612f261","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310956","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:235c12a5-eeec-4bef-b519-58c517ee26c9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1368","original_object":"UniProtKB:P31422"}
{"id":"9cde0615-2537-45dc-bd31-99f4c066c1ce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34385","predicate":"biolink:affects","object":"NCBIGene:25469","sources":[{"id":"urn:uuid:c3785b06-9b6b-4a2e-982e-f4eb53f16f3a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2416","original_object":"UniProtKB:P15385"}
{"id":"d9706bdd-5734-45e9-81c2-2e043d75652f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:715924","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:6db41019-5510-45d9-90c7-ffceb8108fee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7656","original_object":"UniProtKB:Q12809"}
{"id":"69a4e47e-1d0c-4e73-9a16-5fab505b396c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2026","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:0481a3c2-d491-4e3c-8547-98cd280c99a5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2026","original_object":"UniProtKB:P31391"}
{"id":"65b57d97-47d4-4ac0-bc98-a54115ba03b0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:183517","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:b024e14f-01fd-4a66-adb8-6f073a66e5e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9262","original_object":"UniProtKB:Q06187"}
{"id":"39484379-b73e-480c-9500-7197ef113994","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6181","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:feaf49cb-9439-4dd3-b05d-60de93312d7d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6181","original_object":"UniProtKB:P52500"}
{"id":"e2e9aff6-be83-450c-8aa1-a3b3ae55779e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:125619","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:db9639bb-1534-4800-a254-e05df23171a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3251","original_object":"UniProtKB:P08908"}
{"id":"bb7f9ee5-0e5a-47dc-a089-71c9b7a11063","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230819","predicate":"biolink:affects","object":"NCBIGene:6507","sources":[{"id":"urn:uuid:92f667b0-2f9b-484c-9898-59725ea4c8da","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4631","original_object":"UniProtKB:P43003"}
{"id":"50b80f53-78c6-4c4a-8a1c-d952d293c31e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231602","predicate":"biolink:affects","object":"NCBIGene:5604","sources":[{"id":"urn:uuid:bbeeb1d2-3e13-4836-9891-c7b240865f04","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7942","original_object":"UniProtKB:Q02750"}
{"id":"4f32bf41-e917-4e26-841a-e3a337a5531c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2004","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:b2402d7d-bfbb-4085-97d7-87129290d415","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2004","original_object":"UniProtKB:P31391"}
{"id":"25aa0ee1-d3fe-4824-a9de-4f5be569f00a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92539","predicate":"biolink:affects","object":"NCBIGene:29412","sources":[{"id":"urn:uuid:8511a713-5c96-405a-bf55-6b766688095f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9","original_object":"UniProtKB:P43140"}
{"id":"6f11b54c-a76f-4daa-9447-2d8ff8a979ed","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24779755","predicate":"biolink:affects","object":"NCBIGene:81726","sources":[{"id":"urn:uuid:30637ad8-c6ca-436d-9de6-163a9b4a6a21","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"competitive_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3213","original_object":"UniProtKB:Q62967"}
{"id":"315c3cac-16a2-4718-9a22-68e43b5ad444","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3981","predicate":"biolink:affects","object":"NCBIGene:55584","sources":[{"id":"urn:uuid:b074fb76-2b71-4a06-ac34-0627e45f8ffd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3981","original_object":"UniProtKB:Q9UGM1"}
{"id":"e87c9e75-78d6-4b13-a592-b5e0a2c60bd5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:32316","predicate":"biolink:affects","object":"NCBIGene:6532","sources":[{"id":"urn:uuid:75292be1-ba60-4006-a6a4-84d89f8abc52","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:103","original_object":"UniProtKB:P31645"}
{"id":"a75f0e40-7dc3-41e4-8f39-eac54e9581c7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EVH7O0422T","predicate":"biolink:affects","object":"NCBIGene:1241","sources":[{"id":"urn:uuid:3437a1fc-199a-4b0b-9b4e-9cb0b1afbb4d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6156","original_object":"UniProtKB:Q15722"}
{"id":"0108a8df-38f2-4a23-a96d-fab6cc8e6dcc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:39112","predicate":"biolink:affects","object":"NCBIGene:11183","sources":[{"id":"urn:uuid:fc2bc0b4-9cef-4bd4-ac3e-aae9eef438d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5710","original_object":"UniProtKB:Q9Y4K4"}
{"id":"a9b06a01-9e83-4cc7-b39f-3821e2d5a1c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4031","predicate":"biolink:affects","object":"NCBIGene:2357","sources":[{"id":"urn:uuid:c3ee935b-61aa-42f9-ab4f-cd5ff2b78886","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1024","original_object":"UniProtKB:P21462"}
{"id":"3b0c7b9d-82c6-4e01-8ce3-1ebaea54e58d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10361101","predicate":"biolink:affects","object":"NCBIGene:51776","sources":[{"id":"urn:uuid:a44bc10e-9e3b-4b7e-9fbc-99580ba39ea6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8194","original_object":"UniProtKB:Q9NYL2"}
{"id":"814bb6a9-b0d2-4d03-8550-9636fa9b07a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91623353","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:8c0612f4-c9be-4749-aa43-89fa834904cc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7927","original_object":"UniProtKB:Q9GZQ4"}
{"id":"009e8629-4fc0-4aca-bc9e-c0b6fb798685","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:PJX9GH268R","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:c3297e02-3cbd-4874-b726-9b009fce0a02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9857","original_object":"UniProtKB:Q06187"}
{"id":"e7ae787a-d73b-479e-bcb0-2e4d1e064aa6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:447278","predicate":"biolink:affects","object":"NCBIGene:9453","sources":[{"id":"urn:uuid:9d172393-7150-4a08-906f-74ab11b9cc85","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3199","original_object":"UniProtKB:O95749"}
{"id":"c452b168-7093-412a-a65d-83686043eeac","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6267","predicate":"biolink:affects","object":"NCBIGene:2358","sources":[{"id":"urn:uuid:91b7b5bc-a514-4121-9313-60550a4dcd02","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6267","original_object":"UniProtKB:P25090"}
{"id":"73eea1a4-d392-4b90-a075-498ba5d5d7bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7575","predicate":"biolink:affects","object":"UniProtKB:P27732","sources":[{"id":"urn:uuid:228d9dcb-67bb-4bf5-b0f4-76d2874c332c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2523","original_object":"UniProtKB:P27732"}
{"id":"b89d62fa-a516-474d-8a61-9a713f55c92b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86277843","predicate":"biolink:affects","object":"NCBIGene:6046","sources":[{"id":"urn:uuid:a9c2d83a-0be8-47c4-aa0c-22a219007805","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7808","original_object":"UniProtKB:P25440"}
{"id":"3d63b887-1031-4528-a8cb-c0c6d2a321a4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:169447817","predicate":"biolink:affects","object":"NCBIGene:30811","sources":[{"id":"urn:uuid:ca1be228-23b7-4494-bbc4-ea7b4683be12","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13138","original_object":"UniProtKB:P57058"}
{"id":"15976077-b7ab-40b1-a3eb-4ae6511744e1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73754995","predicate":"biolink:affects","object":"NCBIGene:148","sources":[{"id":"urn:uuid:11798325-140a-44d9-a027-2f3f1d48bd1c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:482","original_object":"UniProtKB:P35348"}
{"id":"f2162b67-5c1e-41d2-930b-5e05a553c05f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5700","predicate":"biolink:affects","object":"NCBIGene:1137","sources":[{"id":"urn:uuid:aa3b43ed-ddde-49fe-b56d-25d0fc96fa59","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:3963","original_object":"UniProtKB:P43681"}
{"id":"f0a9908b-3ccd-4bd3-93ea-0f3099ca6c0f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:31799","predicate":"biolink:affects","object":"NCBIGene:50837","sources":[{"id":"urn:uuid:fa40371a-9aa6-4925-a31f-ebf5e1157157","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12427","original_object":"UniProtKB:Q9NYW3"}
{"id":"ecd709fa-7007-40b2-aaac-e49c9bacb2ef","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311224","predicate":"biolink:affects","object":"NCBIGene:5733","sources":[{"id":"urn:uuid:dcbe1a21-ef13-415f-a13d-c4f03893d000","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1937","original_object":"UniProtKB:P43115"}
{"id":"338fd984-f950-470d-8d8a-d30e4969ed7b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H0EVX3PS4B","predicate":"biolink:affects","object":"NCBIGene:3358","sources":[{"id":"urn:uuid:509852cd-0fb5-4c5c-aabb-b79bdf506673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:174","original_object":"UniProtKB:P28335"}
{"id":"d11015f8-5dda-452e-914c-be8fd442af99","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16958","predicate":"biolink:affects","object":"NCBIGene:293648","sources":[{"id":"urn:uuid:f56bb251-e5d8-457c-b487-f6828eefe3b8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2365","original_object":"UniProtKB:Q7TN41"}
{"id":"e83f0f60-36b9-4a1a-8ef0-eaf665bbb78a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16977","predicate":"biolink:affects","object":"NCBIGene:222545","sources":[{"id":"urn:uuid:0fd2dd23-2f42-44e7-8870-794f60e00be0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:720","original_object":"UniProtKB:Q5T6X5"}
{"id":"fd31da38-736b-4dc6-8b74-9a2986e83840","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:172918","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:87a537ee-9990-4673-862c-566ba6a13ab9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11250","original_object":"UniProtKB:P0C6U8"}
{"id":"b33c90cb-8a1a-4f0e-98c6-a377bb0776f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5287596","predicate":"biolink:affects","object":"NCBIGene:7177","sources":[{"id":"urn:uuid:1a0d1049-438f-4938-acfe-101296a0f204","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9333","original_object":"UniProtKB:Q15661"}
{"id":"e2edca96-9617-41a2-8f42-1f8bd49c6cf3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139600335","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:a47c2644-ef99-4881-abaa-ae0d28d4b788","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10549","original_object":"UniProtKB:P36888"}
{"id":"9b100048-a181-495f-b68e-aba94a6e526a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:644196","predicate":"biolink:affects","object":"NCBIGene:834","sources":[{"id":"urn:uuid:8a93a080-6be3-465a-88cc-ef73712b6f9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5302","original_object":"UniProtKB:P29466"}
{"id":"8bae7d1d-9175-4eb9-8379-a5b025a08a09","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:168654812","predicate":"biolink:affects","object":"NCBIGene:29933","sources":[{"id":"urn:uuid:5cc1a902-dfb6-46b9-a4aa-594fede584ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12945","original_object":"UniProtKB:Q9UNW8"}
{"id":"539c9b37-3029-4fa4-8ec8-418a7d490aba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134990","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:12e1d2e5-94b2-49d8-83de-8972c1df61a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:198","original_object":"UniProtKB:P49286"}
{"id":"2bf07f51-28a4-4f8e-9b82-b68cf7e48396","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:46024","predicate":"biolink:affects","object":"NCBIGene:10014","sources":[{"id":"urn:uuid:4dfe7ac8-1d81-4b29-9f1f-94c43769ae14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7005","original_object":"UniProtKB:Q9UQL6"}
{"id":"f844270c-cce1-41a2-8622-84c7fddbfee3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:85993","predicate":"biolink:affects","object":"NCBIGene:1019","sources":[{"id":"urn:uuid:b0aec07b-ddd2-42a5-8caa-c1559ab32d11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7380","original_object":"UniProtKB:P11802"}
{"id":"5d4aa1f5-62f1-4f11-aac1-e40935d77b81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:7CZ390V26X","predicate":"biolink:affects","object":"NCBIGene:51284","sources":[{"id":"urn:uuid:bdc8d463-139e-412b-a4e5-9ef048e21f45","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11307","original_object":"UniProtKB:Q9NYK1"}
{"id":"0dcd994c-15f7-43ce-8113-1ee99e7062b3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28790","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:5467bd06-768b-435b-a0d7-fdafe105e31c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5","original_object":"UniProtKB:P21728"}
{"id":"e0d659eb-aa0f-422c-ba59-28e4ac0ef151","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D1LXQ45S1O","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:87632753-9b65-4e75-8d50-502c639954ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8957","original_object":"UniProtKB:P52333"}
{"id":"0ffc76c1-c3c2-4c30-b0fb-59f4e3a61796","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:97A09L5JCK","predicate":"biolink:affects","object":"NCBIGene:5290","sources":[{"id":"urn:uuid:15292b94-d819-471b-a98f-137f6c48052f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10601","original_object":"UniProtKB:P42336"}
{"id":"342c1418-4e44-4747-92f7-395583b4bc7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25262525","predicate":"biolink:affects","object":"NCBIGene:5770","sources":[{"id":"urn:uuid:92a7949e-b6e3-45f5-af9f-a5cb91df6ad2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10374","original_object":"UniProtKB:P18031"}
{"id":"234c8ad1-060a-4146-9ab2-30cabe3412bb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48538","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:4aea364d-014d-4c1d-9268-aeb9958b5b33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:33","original_object":"UniProtKB:P18825"}
{"id":"4eb584e3-ea1c-458e-b8f1-ade2f73224f0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:102129367","predicate":"biolink:affects","object":"NCBIGene:259289","sources":[{"id":"urn:uuid:cdedae6b-4118-4a6a-80bb-386fc33cb5ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12469","original_object":"UniProtKB:P59537"}
{"id":"3eec76df-b024-486d-8f23-bc483d897976","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138393290","predicate":"biolink:affects","object":"NCBIGene:11035","sources":[{"id":"urn:uuid:0462f97b-857c-4eaf-9a0a-e7701b6c998b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10388","original_object":"UniProtKB:Q9Y572"}
{"id":"968be4c7-d0ba-4d60-b562-d15e5418759f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6439022","predicate":"biolink:affects","object":"NCBIGene:5729","sources":[{"id":"urn:uuid:c8ce7b83-e9d6-4047-81a7-8147ee72fd92","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1887","original_object":"UniProtKB:Q13258"}
{"id":"ae939e66-9b44-465f-b19b-aacb4cb02a22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11913","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:a01e2dbe-b532-4b1f-a009-4df213316144","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11913","original_object":"UniProtKB:Q8WXD0"}
{"id":"7f7057d0-2069-419b-8cda-8a86fb342bbf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17489","predicate":"biolink:affects","object":"NCBIGene:15165","sources":[{"id":"urn:uuid:03bdf3b8-6750-40df-ac26-483ecc9e91a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2352","original_object":"UniProtKB:O88704"}
{"id":"a250f3ca-8666-4c6e-b807-3c55cfcd0e4f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1297","predicate":"biolink:affects","object":"NCBIGene:84539","sources":[{"id":"urn:uuid:2ade6aa4-fb82-43c7-acbc-bc336844386f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1297","original_object":"UniProtKB:Q969V1"}
{"id":"01705097-97d5-4081-a1d0-affb4c99dfa1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5866327","predicate":"biolink:affects","object":"NCBIGene:2914","sources":[{"id":"urn:uuid:6491825d-6b50-454f-9d01-cf1fd90880bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1416","original_object":"UniProtKB:Q14833"}
{"id":"927e45f2-b4de-4454-9d53-aca8874d9fa9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:56947052","predicate":"biolink:affects","object":"NCBIGene:2222","sources":[{"id":"urn:uuid:7485532f-6e52-4ba6-b481-c74d340f06cd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3128","original_object":"UniProtKB:P37268"}
{"id":"b884542b-daa9-4121-a4e1-41faaedd253d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CEO54NH393","predicate":"biolink:affects","object":"NCBIGene:23566","sources":[{"id":"urn:uuid:b7e0571e-728a-4ecd-92e3-150e755adc33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2905","original_object":"UniProtKB:Q9UBY5"}
{"id":"bd782d15-8ddf-4308-95c9-9cfcefe3b6da","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4798","predicate":"biolink:affects","object":"NCBIGene:25874","sources":[{"id":"urn:uuid:0d3bfbce-31d1-42ba-a420-a64f091e3dea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6647","original_object":"UniProtKB:O95563"}
{"id":"7846e56b-a060-4b94-bb4c-a80c410556e5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:405386","predicate":"biolink:affects","object":"NCBIGene:2224","sources":[{"id":"urn:uuid:b30ff654-7f21-4aa8-b66f-0051e3c67789","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3174","original_object":"UniProtKB:P14324"}
{"id":"3c4fd844-e001-41c8-8e12-61eeefdcb7db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1524","predicate":"biolink:affects","object":"NCBIGene:25340","sources":[{"id":"urn:uuid:2b87dfc5-fc6d-40b4-9b1f-a2cb0927acc1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1524","original_object":"UniProtKB:Q63634"}
{"id":"faedf60d-6a62-4968-9ad1-ba42ef51e4bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91938093","predicate":"biolink:affects","object":"NCBIGene:5564","sources":[{"id":"urn:uuid:603202da-6eaf-4983-be30-837aea7d6ecb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8821","original_object":"UniProtKB:Q9Y478"}
{"id":"c0a9395a-e3aa-4904-b0f8-b600bf829282","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2319","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:7a71662b-4aa6-4c1d-814e-c562179a1a5c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2319","original_object":"UniProtKB:Q92952"}
{"id":"a7c7ae8b-07b1-4736-ba8c-13148a42c763","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:47381","predicate":"biolink:affects","object":"NCBIGene:9311","sources":[{"id":"urn:uuid:5cd38a11-b262-47f7-8f33-44e9133885ac","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2714","original_object":"UniProtKB:Q9UHC3"}
{"id":"bc3e6876-058d-4211-bf81-06f6cf29fbb7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11434","predicate":"biolink:affects","object":"NCBIGene:2925","sources":[{"id":"urn:uuid:df396216-06c0-4cd6-b5c1-0079438221d2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11434","original_object":"UniProtKB:P30550"}
{"id":"41de2166-592f-4f1d-a169-3c2d6f083b26","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:736736","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:eedffa9a-4022-4944-bf85-2f94103b1ffc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:400","original_object":"UniProtKB:P29274"}
{"id":"4e14c3ef-02e0-4229-98eb-0672ced02843","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:IA262432Y9","predicate":"biolink:affects","object":"NCBIGene:2892","sources":[{"id":"urn:uuid:b42f2966-0046-4c28-b43a-ca35815cec46","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4304","original_object":"UniProtKB:P42263"}
{"id":"3f86aad5-4fd4-477a-8027-5d8790979a3c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4046","predicate":"biolink:affects","object":"NCBIGene:65032","sources":[{"id":"urn:uuid:f9e5296f-45cb-4f0b-aaae-c854c8133088","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:277","original_object":"UniProtKB:P32305"}
{"id":"6aa584b2-529a-482d-9dcc-ee7d17329786","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4204373","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:297f92c7-c696-40d7-b1e8-685a964efc01","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9937","original_object":"UniProtKB:P36888"}
{"id":"296c5d2f-a760-4996-ac75-0c6f131dc40c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:10082","predicate":"biolink:affects","object":"NCBIGene:29413","sources":[{"id":"urn:uuid:75638751-3420-4471-9431-c2205487e3e0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:517","original_object":"UniProtKB:P23944"}
{"id":"6f3f7208-d059-4659-9ce7-885b3dad4e81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:X8EOD1X17Q","predicate":"biolink:affects","object":"NCBIGene:1369","sources":[{"id":"urn:uuid:cd5e97f6-deea-4ef1-89cc-dc38f67b4625","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8675","original_object":"UniProtKB:P15169"}
{"id":"dfacc395-ccfa-4928-8833-5f35f30e0348","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3907","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:ca759ee1-02f2-44be-97a6-a6466605fef5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3907","original_object":"UniProtKB:Q8TDU9"}
{"id":"0d707648-7bab-43e9-b2a6-f9ade58be1db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:R92JB88O88","predicate":"biolink:affects","object":"NCBIGene:3359","sources":[{"id":"urn:uuid:73ee2fed-45b3-4690-9fb7-2647838437a6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2302","original_object":"UniProtKB:P46098"}
{"id":"a5ecfc38-4be1-4c7f-a210-9f8bd29eeda8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:121231408","predicate":"biolink:affects","object":"NCBIGene:3055","sources":[{"id":"urn:uuid:5b487b95-c045-4a0f-9d8e-3c1e7a0fa67e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9186","original_object":"UniProtKB:P08631"}
{"id":"561812e6-b9bb-4e99-a805-d28008873f0a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:177494","predicate":"biolink:affects","object":"NCBIGene:135","sources":[{"id":"urn:uuid:980cf17b-f4a3-4153-93ea-a635778612c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5611","original_object":"UniProtKB:P29274"}
{"id":"27d620d2-aa53-4b49-92f5-85758f404f8f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1550579","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:28ffc7de-8076-4f8a-9e17-abfb71da0b06","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1443","original_object":"UniProtKB:O00222"}
{"id":"999dfb91-eb7b-4db5-be62-fd7d24307a43","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:453011","predicate":"biolink:affects","object":"NCBIGene:142","sources":[{"id":"urn:uuid:6e17389f-f8b7-4dbb-9f42-4108c4d2b761","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11349","original_object":"UniProtKB:P09874"}
{"id":"eba42de5-aa36-4813-bcd9-22cebf8237f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817479","predicate":"biolink:affects","object":"NCBIGene:50577","sources":[{"id":"urn:uuid:23bd20a7-d41d-4b1b-936a-d20391227816","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6083","original_object":"UniProtKB:Q62805"}
{"id":"fad5ae81-0dfd-4a53-8ce8-f7e6ca9b0ef7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755009","predicate":"biolink:affects","object":"NCBIGene:53829","sources":[{"id":"urn:uuid:ac17b3c8-911c-4719-ba48-cffd03dad6a8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1774","original_object":"UniProtKB:Q9BPV8"}
{"id":"b3ef3797-d09c-4560-a339-cef5c0d793e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:45863","predicate":"biolink:affects","object":"NCBIGene:203068","sources":[{"id":"urn:uuid:8fd88479-1737-4e1a-afb6-c600c51c815f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2770","original_object":"UniProtKB:P07437"}
{"id":"8b83fcb8-5f3b-4c43-b9ae-080d72a77032","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:91827369","predicate":"biolink:affects","object":"NCBIGene:29234","sources":[{"id":"urn:uuid:b15df325-99e7-4593-a833-c1fd47917354","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8547","original_object":"UniProtKB:O08726"}
{"id":"b8ea9601-ec3a-4fd2-bd97-e7897abc2ae3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:230710","predicate":"biolink:affects","object":"NCBIGene:22066","sources":[{"id":"urn:uuid:d632a0ea-d67c-47ec-aeda-8dd58ba31df2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4255","original_object":"UniProtKB:Q9QUQ5"}
{"id":"f7e985ec-3216-4a9e-b7e4-b330fbd315f2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25886893","predicate":"biolink:affects","object":"NCBIGene:24929","sources":[{"id":"urn:uuid:a76d3aea-221e-43b1-a50a-34b6847fd29d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1892","original_object":"UniProtKB:P34980"}
{"id":"0fe7460f-8c6b-4512-844c-f506fc326144","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7478","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:907a5d1a-ec4f-4b4d-baa1-289653d4197d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:45","original_object":"UniProtKB:P30939"}
{"id":"921c62c6-c67c-4b32-90a0-f65c440ef8bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42638","predicate":"biolink:affects","object":"NCBIGene:29850","sources":[{"id":"urn:uuid:ea453bd8-bb3c-4cb0-9d58-6dcb10572cde","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2447","original_object":"UniProtKB:Q9NZQ8"}
{"id":"7bcb24d1-51d3-42b1-97e1-9886b3a2b1e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59627005","predicate":"biolink:affects","object":"NCBIGene:25","sources":[{"id":"urn:uuid:d658550a-e1b2-4ccd-9e28-af55bdbe7380","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8138","original_object":"UniProtKB:P00519"}
{"id":"9b82797c-cc5c-4fa7-a6eb-774d40155e46","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:28499","predicate":"biolink:affects","object":"NCBIGene:1956","sources":[{"id":"urn:uuid:2d7b0342-5341-4c70-b372-16339e388507","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11052","original_object":"UniProtKB:P00533"}
{"id":"5f9dc7b4-505a-44bf-93a7-404191adafa4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15760","predicate":"biolink:affects","object":"NCBIGene:111174","sources":[{"id":"urn:uuid:0a4a2587-3673-4025-9221-807ff9f43a50","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2150","original_object":"UniProtKB:Q923Y8"}
{"id":"12ae64dc-51a5-4d3e-b2ce-0a697a58d672","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:17364","predicate":"biolink:affects","object":"NCBIGene:2904","sources":[{"id":"urn:uuid:cff71f01-9529-4379-bb55-0e0e02d652d6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6511","original_object":"UniProtKB:Q13224"}
{"id":"6c274220-9d14-4cd2-adff-d5b8a1ae5184","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L1E28E0J8F","predicate":"biolink:affects","object":"NCBIGene:57105","sources":[{"id":"urn:uuid:e0aaee40-72ae-48c0-8c16-3c42aea6c4a0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5861","original_object":"UniProtKB:Q9NS75"}
{"id":"1eb251cd-b067-4b9d-95da-ca30ad04b83d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91650","predicate":"biolink:affects","object":"NCBIGene:80024","sources":[{"id":"urn:uuid:f5575cf8-09f2-41e9-842d-50ad214f3a11","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11611","original_object":"UniProtKB:Q6J4K2"}
{"id":"5feeba5f-70a0-4bbb-b2cb-2e68cba9219a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3084","predicate":"biolink:affects","object":"NCBIGene:1129","sources":[{"id":"urn:uuid:c899a4cc-8ff4-45b4-8841-e23fec51efaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:297","original_object":"UniProtKB:P08172"}
{"id":"3c9826af-bbd2-4470-b1b6-4418ac1bddc5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:L49V5G013I","predicate":"biolink:affects","object":"NCBIGene:6097","sources":[{"id":"urn:uuid:c4d329a3-427d-4e75-af25-b7bc8fbb4317","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9661","original_object":"UniProtKB:P51449"}
{"id":"ae596d39-bf62-4f46-91ad-02c81e378df6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11993875","predicate":"biolink:affects","object":"NCBIGene:1571","sources":[{"id":"urn:uuid:5dbbf643-f907-4b69-b083-5a8e3e37186e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8756","original_object":"UniProtKB:P05181"}
{"id":"8043c846-a83e-463a-a860-8ff00bfb58ab","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:3350","sources":[{"id":"urn:uuid:40f4ee30-f37e-4c19-9fbf-478edbffc35d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P08908"}
{"id":"0486a3a3-90cc-4218-ac6d-83be51e3d916","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46911384","predicate":"biolink:affects","object":"NCBIGene:24418","sources":[{"id":"urn:uuid:3f9a772c-7e39-4ed8-bfb2-a4d65a1067e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6436","original_object":"UniProtKB:P31424"}
{"id":"17defeed-8bc4-4132-82ad-562957573339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8086","predicate":"biolink:affects","object":"NCBIGene:93","sources":[{"id":"urn:uuid:f36cdde5-7b62-4d05-ac05-780bb8b4b1f2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:8086","original_object":"UniProtKB:Q13705"}
{"id":"559dd48e-f3d0-4795-a0fe-97deafcbdb27","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2058","predicate":"biolink:affects","object":"NCBIGene:6755","sources":[{"id":"urn:uuid:a99ea084-2687-4e5f-98a5-57ed0339f5f6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2058","original_object":"UniProtKB:P35346"}
{"id":"6f52023f-40c5-4ed2-b30c-f06e97b2dcec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:909822","predicate":"biolink:affects","object":"NCBIGene:3782","sources":[{"id":"urn:uuid:3ebdf341-13a3-4394-8378-c624e1c71d07","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2323","original_object":"UniProtKB:Q9UGI6"}
{"id":"9197fe26-eef9-4a13-89c0-e32c32f12f2a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8247","predicate":"biolink:affects","object":"NCBIGene:25229","sources":[{"id":"urn:uuid:db017cd7-243b-43c4-8874-7b798d1f934c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:328","original_object":"UniProtKB:P08482"}
{"id":"0a7d4c3b-f994-4319-803f-7a4dee95c10a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AP031EC2NI","predicate":"biolink:affects","object":"NCBIGene:9152","sources":[{"id":"urn:uuid:46b881da-7868-4184-9548-35260ffc81a2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11298","original_object":"UniProtKB:Q9Y345"}
{"id":"96c217f9-6aee-4256-86e9-8c8b1572556b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:821","predicate":"biolink:affects","object":"NCBIGene:3577","sources":[{"id":"urn:uuid:8a723a71-4b51-41c3-a214-754635362f17","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:821","original_object":"UniProtKB:P25024"}
{"id":"aa408985-db4c-40ad-b3ce-4a8324e6e5e8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:232188","predicate":"biolink:affects","object":"NCBIGene:79208","sources":[{"id":"urn:uuid:83b540f7-1d29-4fa9-8412-600eef9808b0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8124","original_object":"UniProtKB:P54757"}
{"id":"33f499a8-e375-4ead-974e-970678dfa983","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:3092","predicate":"biolink:affects","object":"NCBIGene:2557","sources":[{"id":"urn:uuid:18fbaa60-7cfa-4668-b9fc-fe51de390089","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2312","original_object":"UniProtKB:P48169"}
{"id":"b8e39b81-3c16-4ed3-8703-56814bc1907b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:H4X2M2NN5N","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:93b91d5c-e747-45d5-9050-677c2cb078e7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9921","original_object":"UniProtKB:P36888"}
{"id":"55ee882f-298c-4c4e-a1a1-0fd19156d598","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5118","predicate":"biolink:affects","object":"NCBIGene:25327","sources":[{"id":"urn:uuid:3f847a80-23ed-4c2f-8d97-201786aa35ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:203","original_object":"UniProtKB:P25122"}
{"id":"5e74d556-ee8c-4a7e-a456-ceb3b71e5296","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5310954","predicate":"biolink:affects","object":"NCBIGene:64805","sources":[{"id":"urn:uuid:59fe8718-c36c-4a55-a94b-e1f0f3cd6700","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1756","original_object":"UniProtKB:Q9H244"}
{"id":"ba73da69-d9ed-4957-906e-c0d1764852e9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230540","predicate":"biolink:affects","object":"NCBIGene:4915","sources":[{"id":"urn:uuid:dabe9cca-fbda-45f9-8526-d8f0ae686529","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7962","original_object":"UniProtKB:Q16620"}
{"id":"c9978970-b000-4394-b03f-c10cc06676ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11142","predicate":"biolink:affects","object":"NCBIGene:259197","sources":[{"id":"urn:uuid:8c0a494d-b91b-408a-b52f-71b146c6ae10","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11142","original_object":"UniProtKB:O14931"}
{"id":"555b1b1f-f65a-410c-a449-7d7e949e8a1c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:77850","predicate":"biolink:affects","object":"NCBIGene:26379","sources":[{"id":"urn:uuid:26c8d70d-d699-490c-8743-b7e994a59184","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2830","original_object":"UniProtKB:O08580"}
{"id":"e167b5bc-ff92-443a-bd70-29e191e670fd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15553","predicate":"biolink:affects","object":"NCBIGene:5737","sources":[{"id":"urn:uuid:c0ca4dba-1165-4c15-9efa-de78dd203e5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1884","original_object":"UniProtKB:P43088"}
{"id":"32a78f47-4d95-4e88-a55e-6a19cf11d5e4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:D01E4B1U35","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:463eaa9a-0044-436c-aecf-7c3b19bc8ee3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9862","original_object":"UniProtKB:Q06187"}
{"id":"a1b80db7-568b-4ec9-b6c6-481e8037e1ee","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135983","predicate":"biolink:affects","object":"NCBIGene:5745","sources":[{"id":"urn:uuid:0efec165-e7c5-4270-9d12-40b92a749de8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4448","original_object":"UniProtKB:Q03431"}
{"id":"b5b43987-4fff-40f5-96c6-4e0697c07fe7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:135379","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:2a615815-b84f-4aed-b2ee-33982292f96b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:84","original_object":"UniProtKB:P28223"}
{"id":"51244c8b-c97e-45f6-a335-ffdb17ed3640","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:196819","predicate":"biolink:affects","object":"NCBIGene:5021","sources":[{"id":"urn:uuid:5b96d261-c697-4af5-b6db-a0b1f8e4604e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2243","original_object":"UniProtKB:P30559"}
{"id":"13599cc5-f403-4b5b-a81b-23d9180b8622","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:656733","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:613c535c-dc53-4bdd-b52e-502ffc106a49","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2320","original_object":"UniProtKB:Q9H2S1"}
{"id":"3b40dea1-ca1a-4bac-9d77-3ff944bc0bfc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6221","predicate":"biolink:affects","object":"NCBIGene:2912","sources":[{"id":"urn:uuid:61e94d25-ff01-47a3-8ef6-0ed7bd6bedee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6221","original_object":"UniProtKB:Q14416"}
{"id":"e4f89561-fafc-49d7-b11a-cc5e4ce2e66a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:154699456","predicate":"biolink:affects","object":"NCBIGene:4544","sources":[{"id":"urn:uuid:d82a824d-e87b-44fa-8987-0bb214f7e026","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11196","original_object":"UniProtKB:P49286"}
{"id":"78da1887-6de9-4bdd-ad5e-d7fb8dc59e86","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4463007","predicate":"biolink:affects","object":"NCBIGene:3717","sources":[{"id":"urn:uuid:92183356-e26a-4fa0-851a-dc6aecaa5e5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10527","original_object":"UniProtKB:O60674"}
{"id":"5f60c9e8-2c27-44c5-b5f8-7b1eba8e7299","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1842","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:ee86a07b-40dc-4a21-9e37-de88b91f399f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1842","original_object":"UniProtKB:Q62035"}
{"id":"dfed50d9-9ae5-4b7d-acb9-8c2f8d8e083d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15738","predicate":"biolink:affects","object":"NCBIGene:5567","sources":[{"id":"urn:uuid:da4ca9e5-26ce-4924-832c-a3545e766fa3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:346","original_object":"UniProtKB:P22694"}
{"id":"a722698f-8b2a-4bb1-89ec-1b825ca4ac10","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:AH2E5UQ11Y","predicate":"biolink:affects","object":"NCBIGene:2166","sources":[{"id":"urn:uuid:99da4280-8a89-476c-9aac-41d4efe6d732","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9012","original_object":"UniProtKB:O00519"}
{"id":"cfdb0af8-daf3-4973-beb2-b694ca696ff8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2024","predicate":"biolink:affects","object":"NCBIGene:20609","sources":[{"id":"urn:uuid:8d7ef6c4-5bd6-4b9b-ae00-0cd29202104d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2024","original_object":"UniProtKB:O08858"}
{"id":"ecb9d61a-64f3-4d8a-be0a-1be38fd74303","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:106350","predicate":"biolink:affects","object":"NCBIGene:6576","sources":[{"id":"urn:uuid:d980e007-d4cc-4efc-8f8e-cc3da2704a75","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12853","original_object":"UniProtKB:P53007"}
{"id":"e3250018-1a21-4f31-b9a4-cb2219e09e71","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:59625954","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:713d801f-67c6-46fb-b428-51e4794fc075","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10661","original_object":"UniProtKB:Q99685"}
{"id":"47ff9d38-a7fe-4762-a6a4-d892f958525e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:174330","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:abbe9ff8-2c3b-4122-9ca3-4291747b42e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4766","original_object":"UniProtKB:Q05940"}
{"id":"5927fe92-1261-4f5b-bc42-16f53040c18a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:2PRJ7DX38T","predicate":"biolink:affects","object":"NCBIGene:415116","sources":[{"id":"urn:uuid:e5472e89-2c02-46ae-be51-ec0f3fe8316b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12708","original_object":"UniProtKB:Q86V86"}
{"id":"bfbbadfb-7517-4b00-9a21-4b718acf241b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:W34UO2M4T6","predicate":"biolink:affects","object":"NCBIGene:26524","sources":[{"id":"urn:uuid:ca0e7fc5-dbed-40ec-8677-d453bd34efaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5661","original_object":"UniProtKB:Q9NRM7"}
{"id":"182dd54d-d955-464f-9da0-d7b3b1974290","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16132180","predicate":"biolink:affects","object":"NCBIGene:8811","sources":[{"id":"urn:uuid:e2ce613a-9833-4c29-800e-b26e461fc273","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6087","original_object":"UniProtKB:O43603"}
{"id":"a9a07660-c006-4f97-bda8-d3301241face","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:86281591","predicate":"biolink:affects","object":"NCBIGene:139760","sources":[{"id":"urn:uuid:27d1fbfb-0f9c-4449-8246-2552ccc14ee3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10137","original_object":"UniProtKB:Q8TDV5"}
{"id":"ffa4d140-27cf-4450-98d9-e7491a20634f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817501","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:91d1bf9e-4c6b-4f64-b736-5bb3eef0a88d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8330","original_object":"UniProtKB:Q8WXD0"}
{"id":"aa1d6e41-0093-4342-9f50-e986016e990c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:F40IRN5981","predicate":"biolink:affects","object":"NCBIGene:1436","sources":[{"id":"urn:uuid:20bc8c76-605c-4d0c-a7a2-82bb268e9082","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10475","original_object":"UniProtKB:P07333"}
{"id":"bb19eb86-9a83-4c3f-991f-3f11cc0058b6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:134126","predicate":"biolink:affects","object":"NCBIGene:2742","sources":[{"id":"urn:uuid:e7a599a2-05bf-44b4-bbf1-39473daf607b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:4051","original_object":"UniProtKB:P23416"}
{"id":"6ea906dd-7ed4-48ba-8de4-82251dd208a9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:2666","predicate":"biolink:affects","object":"NCBIGene:15566","sources":[{"id":"urn:uuid:0bdc00bc-8c8d-43a4-89ac-8ab9f20982a1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:200","original_object":"UniProtKB:P32304"}
{"id":"db5058e0-f40a-4bfb-a922-8c71ce091510","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817419","predicate":"biolink:affects","object":"NCBIGene:4887","sources":[{"id":"urn:uuid:77856d73-6aef-4805-96a3-d1991205514b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1536","original_object":"UniProtKB:P49146"}
{"id":"ea02e136-c6f8-474c-828a-d623841fecb4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"NCBIGene:170945","sources":[{"id":"urn:uuid:e0822b29-9cc6-4a03-b166-22f11f70c20b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3976","original_object":"UniProtKB:P12389"}
{"id":"827112ef-52d2-4c11-b727-c2c6051312e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:935415","predicate":"biolink:affects","object":"NCBIGene:8242","sources":[{"id":"urn:uuid:d4982b75-4852-4176-974e-be9e21d77fda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7026","original_object":"UniProtKB:P41229"}
{"id":"e2b9b703-1936-4c1a-9776-a912f4e246ba","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10430549","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:4cf9d6ac-b4bd-4cc0-a6f7-ab7fdee1c290","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2929","original_object":"UniProtKB:P21453"}
{"id":"2e248e62-d90d-44dd-9705-a3f4e1d7d540","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:441P620G3P","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:38ce47ac-bf9d-473d-95fc-4740ae0a063f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9426","original_object":"UniProtKB:O15379"}
{"id":"84cd8dfb-1965-4281-b556-3f4732fc4bd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:138684045","predicate":"biolink:affects","object":"NCBIGene:1180","sources":[{"id":"urn:uuid:e08d207a-218c-4b6f-9742-827225e232c7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13343","original_object":"UniProtKB:P35523"}
{"id":"7c776352-246d-47a9-9c28-a38bfa068dbc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:11919","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:b483a735-97eb-408c-8378-0958e205fda8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11919","original_object":"UniProtKB:Q8TDU9"}
{"id":"41c9b734-8135-45dc-a71e-c62982ff4579","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:25468","sources":[{"id":"urn:uuid:6c70c030-b49c-4268-a576-6d265a381bf3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P63142"}
{"id":"c8d5ba30-8552-43c6-825b-44a6625c36c4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:909822","predicate":"biolink:affects","object":"NCBIGene:3781","sources":[{"id":"urn:uuid:55ba216f-7cd1-4440-963e-458488224d35","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2323","original_object":"UniProtKB:Q9H2S1"}
{"id":"24e925fc-e8d4-4d34-acc0-e6e8631caa6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:6180","predicate":"biolink:affects","object":"NCBIGene:24938","sources":[{"id":"urn:uuid:6645e1cb-6ecf-4db8-853e-758d60ec00a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6180","original_object":"UniProtKB:P52500"}
{"id":"1fbcba34-c65c-4a5c-9acf-49478901d80c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:5311493","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:ca29634d-0134-4cba-9721-55901b8bc8bb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1888","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"81d90d0d-c677-4b55-a1f0-ce855d489492","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9840745","predicate":"biolink:affects","object":"NCBIGene:1806","sources":[{"id":"urn:uuid:bd50db79-b4f3-41be-aa99-5f8181e969d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10514","original_object":"UniProtKB:Q12882"}
{"id":"bea19942-2966-4542-a46a-f18e7bc5994d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71200","predicate":"biolink:affects","object":"NCBIGene:7297","sources":[{"id":"urn:uuid:5fd5bfaf-6f7f-4117-9e58-ce91b31b5ab2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5677","original_object":"UniProtKB:P29597"}
{"id":"d2faa19b-f7fb-4c35-90a5-d6ba5c903ae1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13273","predicate":"biolink:affects","object":"NCBIGene:295144","sources":[{"id":"urn:uuid:55cca72a-1a29-4300-b63d-a1a332b89e5a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13273","original_object":"UniProtKB:Q6R6I6"}
{"id":"09df5cd0-cdaf-4971-8496-5ee473e524d3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16133823","predicate":"biolink:affects","object":"NCBIGene:2587","sources":[{"id":"urn:uuid:cfeb6f49-8b6b-4b8a-abac-c69072b805a3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6090","original_object":"UniProtKB:P47211"}
{"id":"f6557fb5-6af2-43b0-8a7a-4f64cd7bbfd8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137321158","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:1a05a626-6ade-403c-90c4-b1c338e243e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10155","original_object":"UniProtKB:P04629"}
{"id":"8f6d16c8-8147-4dc3-ba25-aa159862e13a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:5LO1ZK1LCW","predicate":"biolink:affects","object":"NCBIGene:11251","sources":[{"id":"urn:uuid:f73aedc1-ef41-4959-b6c5-7880826bfc63","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10179","original_object":"UniProtKB:Q9Y5Y4"}
{"id":"79d3a1c1-8817-458e-a827-a44d86fb1d4d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91945","predicate":"biolink:affects","object":"NCBIGene:1132","sources":[{"id":"urn:uuid:d49f46ac-cd35-464e-bfd2-935d13ec1ece","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11498","original_object":"UniProtKB:P08173"}
{"id":"83893ded-3c77-4dd2-835e-523678e458d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48558","predicate":"biolink:affects","object":"NCBIGene:3356","sources":[{"id":"urn:uuid:233b94cd-7647-4ccf-8abb-c55eefc11848","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:52","original_object":"UniProtKB:P28223"}
{"id":"11a4cc1b-388c-4ecd-9fd3-8c9969d6ce19","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:EJL329H95R","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:c5afa772-d763-4413-8b9a-573a1d4c6ad6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:199","original_object":"UniProtKB:P30994"}
{"id":"2de89c01-00ae-4791-a6ed-540b3453bbe3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:GE2T1418SV","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:7dee71e0-4451-49d9-bb07-b21c897a8b9c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7354","original_object":"UniProtKB:P08912"}
{"id":"ca6e5ca9-0642-45c8-a798-0b90329deeb5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:1367095","predicate":"biolink:affects","object":"NCBIGene:319757","sources":[{"id":"urn:uuid:33767ce1-05ee-4ca6-a8a8-e53b70cfe8fc","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10331","original_object":"UniProtKB:P56726"}
{"id":"e6dd84f4-9777-4039-95bc-637da725ba8c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:36773","predicate":"biolink:affects","object":"NCBIGene:277328","sources":[{"id":"urn:uuid:de1297a9-abc0-4409-b20e-565e9167c1dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2422","original_object":"UniProtKB:Q8BLA8"}
{"id":"3abc99bf-970b-469d-a2d8-abaa23038612","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:25147749","predicate":"biolink:affects","object":"NCBIGene:60628","sources":[{"id":"urn:uuid:4636c930-24a3-4cb8-bc26-c75d452eef0d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2899","original_object":"UniProtKB:O08565"}
{"id":"7d0d7dec-8880-4f38-a182-c67fbd9e3e5b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:CC7IZ88XD2","predicate":"biolink:affects","object":"NCBIGene:554","sources":[{"id":"urn:uuid:88a44d08-283d-4753-b53b-643832274b0e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3537","original_object":"UniProtKB:P30518"}
{"id":"0a420954-371a-4e1a-8359-803498062613","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:134163708","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:78de44b1-a250-4312-aae2-dcd8bf6420a7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10233","original_object":"UniProtKB:O00329"}
{"id":"3c58c754-3ddc-4c22-a5b9-74be4ca90080","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:10197","predicate":"biolink:affects","object":"NCBIGene:7855","sources":[{"id":"urn:uuid:ac66c303-da41-4fca-be6b-d6492d0f7437","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antibody_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10197","original_object":"UniProtKB:Q13467"}
{"id":"408eb348-6e38-4119-8d31-df1701dedb4a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:117993213","predicate":"biolink:affects","object":"NCBIGene:1513","sources":[{"id":"urn:uuid:c6ce5af5-bee1-47a9-aba3-4d960a9812ab","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12208","original_object":"UniProtKB:P43235"}
{"id":"76142a61-533b-47ad-b010-7bf616bb8346","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48295","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:c711a733-0a9e-41d4-a518-e3009cbdb502","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:152","original_object":"UniProtKB:P28221"}
{"id":"0d412890-763e-4235-aedf-08c0c3d00924","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71519693","predicate":"biolink:affects","object":"NCBIGene:7294","sources":[{"id":"urn:uuid:77b935ca-efeb-4feb-9ca9-9b80188955c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8148","original_object":"UniProtKB:P42681"}
{"id":"163f6c26-ea61-49dc-8e5f-a0d1d5425946","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:186644","predicate":"biolink:affects","object":"NCBIGene:7421","sources":[{"id":"urn:uuid:4b41871f-43e2-41cc-8a9b-c6d4e1bf456e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2789","original_object":"UniProtKB:P11473"}
{"id":"1331fdaa-2175-4d12-acd5-c5c07882ada9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:41143031","predicate":"biolink:affects","object":"NCBIGene:26575","sources":[{"id":"urn:uuid:578d1c88-f2e3-479a-a9b8-be73c569c5ea","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11562","original_object":"UniProtKB:Q9UGC6"}
{"id":"c0a5072a-062b-41e6-bc69-52f67b4054b9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91367","predicate":"biolink:affects","object":"NCBIGene:9212","sources":[{"id":"urn:uuid:9c30bd21-8f33-47bc-ba52-4478ba5d5a65","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5663","original_object":"UniProtKB:Q96GD4"}
{"id":"cd6f39a2-2e03-4385-8d0f-023a97cfff75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:95289","predicate":"biolink:affects","object":"NCBIGene:5731","sources":[{"id":"urn:uuid:59e49243-ecca-4d17-8e19-e7a3271aae5e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1896","original_object":"UniProtKB:P34995"}
{"id":"460076c9-ff36-4422-a310-fe735bc69a55","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817434","predicate":"biolink:affects","object":"NCBIGene:81753","sources":[{"id":"urn:uuid:b8ac8a57-172c-4f03-8925-4d1501683df8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1828","original_object":"UniProtKB:P70555"}
{"id":"0281fc94-5240-4be7-8bb6-e0520c1c1ea2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2448","predicate":"biolink:affects","object":"NCBIGene:7226","sources":[{"id":"urn:uuid:09bd07d9-1110-403e-9d36-d791f96b7174","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2448","original_object":"UniProtKB:O94759"}
{"id":"08c1b7aa-010f-4950-bc86-da114c6d6e90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90389","predicate":"biolink:affects","object":"NCBIGene:84023","sources":[{"id":"urn:uuid:dd7f3b38-684d-40e8-a765-c6fb95c05b94","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1949","original_object":"UniProtKB:P43114"}
{"id":"2ce02f30-2da7-45d4-ab18-f78a27781a4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:46898088","predicate":"biolink:affects","object":"NCBIGene:24419","sources":[{"id":"urn:uuid:8722cc0b-b4b6-43a9-ba34-45cb38405f2a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6739","original_object":"UniProtKB:P35349"}
{"id":"09a84d61-c618-4327-aeee-4f22f17ede7a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:74766530","predicate":"biolink:affects","object":"UniProtKB:P57059","sources":[{"id":"urn:uuid:d660a334-93fe-4d71-bc28-90764626bea8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9581","original_object":"UniProtKB:P57059"}
{"id":"1b89dd10-4142-4774-bf60-74fa2b5f5549","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10832988","predicate":"biolink:affects","object":"NCBIGene:19220","sources":[{"id":"urn:uuid:c78f652d-33db-4012-82f8-17bc546fc40e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1957","original_object":"UniProtKB:P43117"}
{"id":"bac56197-eea9-4d0e-8cc1-a57f4baef39d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:MU3JD8E9IS","predicate":"biolink:affects","object":"NCBIGene:4067","sources":[{"id":"urn:uuid:762e2475-fea2-4674-8e71-afa938f035e3","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9433","original_object":"UniProtKB:P07948"}
{"id":"a8f24b88-e09a-403c-bbb0-77886637c866","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15578","predicate":"biolink:affects","object":"NCBIGene:10599","sources":[{"id":"urn:uuid:292bd0d8-1b4b-41b4-b367-ca0b90c70b14","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13593","original_object":"UniProtKB:Q9Y6L6"}
{"id":"f0ac2f98-6c9d-430b-bca0-53cb8166c0a7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4436121","predicate":"biolink:affects","object":"NCBIGene:3780","sources":[{"id":"urn:uuid:0cd49f0c-d912-40d8-9d42-92ce2775ffbd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9315","original_object":"UniProtKB:Q92952"}
{"id":"a930c3cb-05a1-45d9-afe2-40b43dcb0dd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:34973","predicate":"biolink:affects","object":"NCBIGene:2903","sources":[{"id":"urn:uuid:43d7cb9a-9042-4f48-8403-229fcebc1137","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4155","original_object":"UniProtKB:Q12879"}
{"id":"b42aeacc-0aa4-400c-b13c-c0105019b1de","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:QY8BWX1LJ5","predicate":"biolink:affects","object":"NCBIGene:6608","sources":[{"id":"urn:uuid:bf9199cb-e693-46cc-88c6-882d4122cd9b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10333","original_object":"UniProtKB:Q99835"}
{"id":"58e5a281-df7b-4454-9fd7-841bfc31a280","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:182436","predicate":"biolink:affects","object":"NCBIGene:8841","sources":[{"id":"urn:uuid:bf80e426-45da-44e1-8579-5a1a45f138d9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7495","original_object":"UniProtKB:O15379"}
{"id":"8f34d7cb-1f47-49b9-97b2-b74848a5b982","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:131801158","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:15dca1e3-fcb5-4a15-92ad-dd7b3c245d5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9684","original_object":"UniProtKB:P23219"}
{"id":"9cf4d9a5-b787-4e1c-b5b8-f44c008ccf03","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:970375","predicate":"biolink:affects","object":"NCBIGene:25818","sources":[{"id":"urn:uuid:f4fc8af1-cd76-42b6-9489-5a5ee334545b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8488","original_object":"UniProtKB:Q9Y337"}
{"id":"5cacbebb-18d5-42e2-a443-b3d5f2ed68b5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:950O97NUPO","predicate":"biolink:affects","object":"NCBIGene:140","sources":[{"id":"urn:uuid:21865352-305b-4d55-9d02-26d38a008c33","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5614","original_object":"UniProtKB:P0DMS8"}
{"id":"e566f440-0c07-47bf-b32b-d375f981eb16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92712","predicate":"biolink:affects","object":"NCBIGene:1133","sources":[{"id":"urn:uuid:bb33dd90-4cbc-4e8c-bb7c-cabc6faf2734","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:320","original_object":"UniProtKB:P08912"}
{"id":"cfd2197f-4e65-4ba3-84c6-476ce32b9b67","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755251","predicate":"biolink:affects","object":"NCBIGene:53978","sources":[{"id":"urn:uuid:3ad2ac3a-0d4a-4143-9944-839dbeee29e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6983","original_object":"UniProtKB:Q9JL06"}
{"id":"9315f5ca-b1a0-4e34-bd5f-484674e9dcde","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16138722","predicate":"biolink:affects","object":"NCBIGene:59272","sources":[{"id":"urn:uuid:da06c4c3-f00a-4c7b-b1e8-39e67564678a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11602","original_object":"UniProtKB:Q9BYF1"}
{"id":"91bf06f7-5874-4afe-8b16-484276fc80e7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:8856","sources":[{"id":"urn:uuid:848837e1-dc56-444a-a571-5375d0635838","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:O75469"}
{"id":"19614779-9f62-49f3-af55-e447c622baa8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11757476","predicate":"biolink:affects","object":"NCBIGene:24889","sources":[{"id":"urn:uuid:001ffc18-ba4c-4a91-b817-c9a207472ad5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:876","original_object":"UniProtKB:P30551"}
{"id":"2ab1ea14-7ff2-4ed0-9bb9-715234a607f7","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:137455315","predicate":"biolink:affects","object":"NCBIGene:4233","sources":[{"id":"urn:uuid:41b24705-3ffa-40f8-bd3b-4cc4b48df04d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11869","original_object":"UniProtKB:P08581"}
{"id":"423b1003-c2a8-4943-aa86-ed7571f56a5d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:8326","predicate":"biolink:affects","object":"NCBIGene:339403","sources":[{"id":"urn:uuid:d30561fb-cb5d-4b52-aeaa-a1897b1bae2b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8326","original_object":"UniProtKB:Q8TDU9"}
{"id":"846db216-d7bf-4b59-b98d-1f484b2ad4a3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60166172","predicate":"biolink:affects","object":"NCBIGene:151306","sources":[{"id":"urn:uuid:3b1fec4c-a266-4bbd-9f39-fcd19428d330","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9078","original_object":"UniProtKB:Q8TDU6"}
{"id":"f50566b5-fe5d-463d-a8ac-22536af8dbf6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:52449","predicate":"biolink:affects","object":"NCBIGene:165140","sources":[{"id":"urn:uuid:f44ca333-e09c-4d3e-97a7-dc956a3f4f2e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3416","original_object":"UniProtKB:Q8TDS5"}
{"id":"e8e2b025-f82c-4aa2-88f8-2c25974481a0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:16078939","predicate":"biolink:affects","object":"NCBIGene:9152","sources":[{"id":"urn:uuid:6cf10583-ce16-4e8f-ad87-f1638695b552","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4622","original_object":"UniProtKB:Q9Y345"}
{"id":"a97c7fa3-eff0-48c2-9645-d36f3239aa00","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:Z07JR07J6C","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:7f681409-0952-41dc-a741-8c319ea5cbbb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:457","original_object":"UniProtKB:P30543"}
{"id":"5e6339dc-ca13-4ba4-aba2-6960e6336f75","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M8238285OA","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:23fbea11-2b8d-4197-9d8f-a2488ea01b87","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9307","original_object":"UniProtKB:O43614"}
{"id":"edf4b98c-3d51-4b0a-8101-755958a7bc81","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122530045","predicate":"biolink:affects","object":"NCBIGene:11343","sources":[{"id":"urn:uuid:e6461fec-6f68-4265-8224-211a5b117399","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11816","original_object":"UniProtKB:Q99685"}
{"id":"090049c2-95da-4400-bd86-7236479fc335","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:76072013","predicate":"biolink:affects","object":"NCBIGene:23476","sources":[{"id":"urn:uuid:b88aefb3-ff97-4d1c-a8e9-44fc9b206b64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11866","original_object":"UniProtKB:O60885"}
{"id":"39ea4592-55a1-4176-8d90-9bd91911fe4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:142418","predicate":"biolink:affects","object":"NCBIGene:155","sources":[{"id":"urn:uuid:7138679a-b0a3-4f3f-921c-75aecff2ac2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10100","original_object":"UniProtKB:P13945"}
{"id":"42985ae0-1eff-42b4-8bcd-655ebde871fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3593","predicate":"biolink:affects","object":"NCBIGene:8484","sources":[{"id":"urn:uuid:d32a9870-948e-4e4c-ba32-e7b50d0862ec","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3593","original_object":"UniProtKB:O60755"}
{"id":"7e06197d-020f-42a8-8d12-6f0f3208e79e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:OEP8JJ3OZR","predicate":"biolink:affects","object":"NCBIGene:5293","sources":[{"id":"urn:uuid:956f0376-f41c-4cba-a2ac-61da91212060","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9425","original_object":"UniProtKB:O00329"}
{"id":"886d139c-4bcf-40f4-b791-5ebec0b7f2e6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:71253","predicate":"biolink:affects","object":"NCBIGene:1813","sources":[{"id":"urn:uuid:38483de2-84f6-4447-8eac-8a4c9175e673","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:22","original_object":"UniProtKB:P14416"}
{"id":"ed964db3-f531-4579-9710-499c7493efd2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:M371870BYL","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:d18e9dcc-c2cd-47b7-ac0d-88903033bf36","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10382","original_object":"UniProtKB:Q12809"}
{"id":"fa5c501d-5948-47df-a08d-3b993c4d33bc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11539096","predicate":"biolink:affects","object":"NCBIGene:2847","sources":[{"id":"urn:uuid:4ca21a95-2bdd-48c8-bd79-e43ea457ddaa","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1303","original_object":"UniProtKB:Q99705"}
{"id":"320e37c8-fa46-4ace-9d62-1947af53bfce","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6717","predicate":"biolink:affects","object":"NCBIGene:5742","sources":[{"id":"urn:uuid:5d4986e1-3d87-42d1-877e-00c0f32524ee","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2593","original_object":"UniProtKB:P23219"}
{"id":"b4efa2f8-9019-4f2c-a040-63dd7a0fcb70","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2060","predicate":"biolink:affects","object":"NCBIGene:6754","sources":[{"id":"urn:uuid:63acca5b-73dd-43c5-b5fa-e9891bbffc3c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2060","original_object":"UniProtKB:P31391"}
{"id":"0ad57def-398b-488f-ab74-5b1fe6baf038","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:5130","predicate":"biolink:affects","object":"NCBIGene:206358","sources":[{"id":"urn:uuid:05166a60-e904-4b68-b33c-a28464115ff1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4194","original_object":"UniProtKB:Q7Z2H8"}
{"id":"91d6d17a-204f-4632-a9de-3d99bf62580c","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:XX8E5WP7FS","predicate":"biolink:affects","object":"NCBIGene:4914","sources":[{"id":"urn:uuid:f827e322-58cd-494f-a63c-7010c117a557","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10257","original_object":"UniProtKB:P04629"}
{"id":"3a4b1660-7859-47b2-a3bb-486a7e50bc37","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10286113","predicate":"biolink:affects","object":"NCBIGene:1361","sources":[{"id":"urn:uuid:3c3a72db-982e-47d7-8c0b-aa823f331f4e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8623","original_object":"UniProtKB:Q96IY4"}
{"id":"e024d565-a759-46d0-9a56-92b932d14060","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:601","predicate":"biolink:affects","object":"NCBIGene:187","sources":[{"id":"urn:uuid:4377cc10-be5e-4921-8d24-f4589d74d4ff","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:601","original_object":"UniProtKB:P35414"}
{"id":"8c3c09e6-e33f-48d7-96a2-c35528439e08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755012","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:5fe5c30a-bd4c-4d35-a703-fad0b2a1ed8b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1837","original_object":"UniProtKB:Q62035"}
{"id":"6c7c664c-0e19-4cc3-b179-7bdbc9104e42","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122530045","predicate":"biolink:affects","object":"NCBIGene:66082","sources":[{"id":"urn:uuid:e30ae2a4-c8dd-44f4-851d-5bdbe81bcd90","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11816","original_object":"UniProtKB:Q8R2Y0"}
{"id":"cdad3d29-3784-44e3-9411-be3884fdba56","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:72696735","predicate":"biolink:affects","object":"NCBIGene:9194","sources":[{"id":"urn:uuid:4d4952e9-3383-44a6-bce8-c1df082aed69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8818","original_object":"UniProtKB:O60669"}
{"id":"05aa8dc7-6d44-4686-bd41-10dedb6803f3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:145712394","predicate":"biolink:affects","object":"NCBIGene:5605","sources":[{"id":"urn:uuid:f0bf54f5-7661-4d42-aa64-a7f8f7c440ae","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10563","original_object":"UniProtKB:P36507"}
{"id":"3ae11b02-af81-48f7-8305-39e89249e4f5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51164","predicate":"biolink:affects","object":"NCBIGene:150","sources":[{"id":"urn:uuid:1747e740-a87c-4818-8d30-4cd97869eca2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:43","original_object":"UniProtKB:P08913"}
{"id":"ebcd289c-aa92-44c4-a696-f57ea1c26798","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3851","predicate":"biolink:affects","object":"NCBIGene:2150","sources":[{"id":"urn:uuid:9d17b850-62e0-405c-b6f9-1350ca430ba7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3851","original_object":"UniProtKB:P55085"}
{"id":"b404d556-a053-4219-bdfc-9052eb1039d9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5062","predicate":"biolink:affects","object":"NCBIGene:7048","sources":[{"id":"urn:uuid:979d6c7d-e4f1-4008-bc6b-da6cf42418d7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5062","original_object":"UniProtKB:P37173"}
{"id":"6c8f9421-e7a1-4ebf-b900-da95420378a6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:63617","predicate":"biolink:affects","object":"NCBIGene:3357","sources":[{"id":"urn:uuid:0705b25c-ec93-4e66-9a8b-1cceecec313e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:48","original_object":"UniProtKB:P41595"}
{"id":"b764a114-9333-47df-92e6-f1111421a2d0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:8S5OIN36X4","predicate":"biolink:affects","object":"NCBIGene:1586","sources":[{"id":"urn:uuid:d3863750-27ce-4fa0-a924-c14a61522c9a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13855","original_object":"UniProtKB:P05093"}
{"id":"4bedfe59-8397-49b7-90d9-e3f5b6fb23c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:90685","predicate":"biolink:affects","object":"NCBIGene:5599","sources":[{"id":"urn:uuid:8a3dc5f2-a6d8-432d-888c-299d1d38f83e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9915","original_object":"UniProtKB:P45983"}
{"id":"3282e936-77d0-44ad-8648-112dd0c15c6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51098","predicate":"biolink:affects","object":"NCBIGene:2324","sources":[{"id":"urn:uuid:b7e30dea-a3e8-44fd-99b6-69e7b753553c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5660","original_object":"UniProtKB:P35916"}
{"id":"e332c663-7a2d-48b1-af9c-1300caf8609a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:2743","sources":[{"id":"urn:uuid:54db87da-cbbf-40f4-a32d-f43c934ce370","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:P48167"}
{"id":"d75a6bc1-bf00-40b2-9e65-995cbbae6a34","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:T61871RKRI","predicate":"biolink:affects","object":"NCBIGene:983","sources":[{"id":"urn:uuid:727aa04f-dcaa-4605-89d4-8d5fee4d4a5f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5707","original_object":"UniProtKB:P06493"}
{"id":"3ea166a5-3628-4f30-b477-b2fa45e40eec","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231350","predicate":"biolink:affects","object":"NCBIGene:2322","sources":[{"id":"urn:uuid:99840684-5a2f-43c5-b1b4-6d8e3bea5194","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7793","original_object":"UniProtKB:P36888"}
{"id":"1d8c1648-f46f-4877-891a-8d1cfe47b73d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:859","predicate":"biolink:affects","object":"NCBIGene:25706","sources":[{"id":"urn:uuid:d1eb2d7a-d88a-4338-86d5-dfab96d45d3d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:859","original_object":"UniProtKB:P30553"}
{"id":"71d228d3-39f9-47c5-a69c-f12a32c98339","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:7565","predicate":"biolink:affects","object":"NCBIGene:778","sources":[{"id":"urn:uuid:3798680a-9550-4b47-a8eb-9a6dcaf15cda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2514","original_object":"UniProtKB:O60840"}
{"id":"222aff9d-2b78-4baf-851c-fc056d0aeb91","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755010","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:27c38bab-6979-4376-ac7e-7d107927b738","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1835","original_object":"UniProtKB:Q62035"}
{"id":"76dcf5a9-f0e9-49d4-8c13-05feea82bb76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:A26QO95U37","predicate":"biolink:affects","object":"NCBIGene:1515","sources":[{"id":"urn:uuid:4ba9a7de-2ec3-4fd3-aa21-c629e6cb38eb","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9855","original_object":"UniProtKB:O60911"}
{"id":"3d096f74-2787-4d09-8f3a-4ef5daa3c6f1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:231222","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:cecb5385-eef8-491c-ac3b-d34a76a1b5e2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8866","original_object":"UniProtKB:P41145"}
{"id":"ae409be8-ee5d-436b-909d-cc45c70d38b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:KZ3DLD11RQ","predicate":"biolink:affects","object":"NCBIGene:6774","sources":[{"id":"urn:uuid:328d0614-49a3-4aa0-8cc1-ab570c4590ed","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12268","original_object":"UniProtKB:P40763"}
{"id":"67aed543-bda9-42d1-82bf-f4a6090c0688","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233314","predicate":"biolink:affects","object":"NCBIGene:2034","sources":[{"id":"urn:uuid:eddb4168-d41a-44c7-a8aa-b03341fdf06b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:12707","original_object":"UniProtKB:Q99814"}
{"id":"49a8c445-8357-45b6-a60b-63d3ac8796c3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:4681","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:8c0f6b87-1af0-4aaf-bec5-3f17f442a80c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2604","original_object":"UniProtKB:Q12809"}
{"id":"6818f738-01a9-4691-a65e-882ec60d91d1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:93227","predicate":"biolink:affects","object":"NCBIGene:18389","sources":[{"id":"urn:uuid:9361d937-a670-41eb-bc83-f48c5e6d9679","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10499","original_object":"UniProtKB:P35377"}
{"id":"02e63581-f36b-473c-b990-74da312013ad","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:FY875H1BG6","predicate":"biolink:affects","object":"NCBIGene:3351","sources":[{"id":"urn:uuid:f749c936-ca16-4f54-8548-5823afe81545","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"partial_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:108","original_object":"UniProtKB:P28222"}
{"id":"9926e3ed-69b8-41fd-8041-366bdc5ff375","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:23056","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:e03fa757-6055-4caf-ac1c-815bd529c870","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:318","original_object":"UniProtKB:P20309"}
{"id":"30e5ae79-e752-4036-8017-b172200bf5ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13580","predicate":"biolink:affects","object":"UniProtKB:P0C6U8","sources":[{"id":"urn:uuid:16f08f55-b41e-418c-a60a-c994d2c8dc84","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13580","original_object":"UniProtKB:P0C6U8"}
{"id":"1b1bdb90-1249-44c5-a168-7d505218bc30","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:ZL7A1UM87X","predicate":"biolink:affects","object":"NCBIGene:207","sources":[{"id":"urn:uuid:c56139d6-7067-44b1-9810-f8dc501dd671","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10908","original_object":"UniProtKB:P31749"}
{"id":"d2ad3983-1db6-4cf5-a48b-ee4539eb79d2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:LJA4M1L5LG","predicate":"biolink:affects","object":"NCBIGene:134","sources":[{"id":"urn:uuid:926d0727-e92e-4808-9716-a06213062346","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5595","original_object":"UniProtKB:P30542"}
{"id":"f342966d-ce9c-4b2b-b685-a7f8e93300a2","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:145122","predicate":"biolink:affects","object":"NCBIGene:7224","sources":[{"id":"urn:uuid:e241c569-bf47-4fa2-9453-2e993a4d0044","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:2441","original_object":"UniProtKB:Q9UL62"}
{"id":"5a490924-86e4-4a84-87d5-513bfcec0e22","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1514","predicate":"biolink:affects","object":"UniProtKB:P21555","sources":[{"id":"urn:uuid:a6b8ca58-58a8-4666-8ae1-197de73a3343","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1514","original_object":"UniProtKB:P21555"}
{"id":"457e1bc5-fd13-4380-94ba-7018ce371f4e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9803617","predicate":"biolink:affects","object":"NCBIGene:2837","sources":[{"id":"urn:uuid:b94f0dc4-a8cc-4bd1-b59d-428c26b64225","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inverse_agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2163","original_object":"UniProtKB:Q9UKP6"}
{"id":"ff2cc9f2-63f6-4aef-b1fe-ef7456dcc13a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:18971832","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:a90e0254-4fe4-42f1-bd4b-9701c2fc5a8a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:21","original_object":"UniProtKB:P30939"}
{"id":"087a8167-5e8a-4260-a5c0-bdef5c881b60","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:6858272","predicate":"biolink:affects","object":"NCBIGene:4985","sources":[{"id":"urn:uuid:e4baa42c-d5b5-4d10-887b-039b9a199ab9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1612","original_object":"UniProtKB:P41143"}
{"id":"867aa865-6c2b-4392-ad3d-324baf99dcc4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:91678","predicate":"biolink:affects","object":"NCBIGene:25590","sources":[{"id":"urn:uuid:70c8c318-0ae2-4f71-a1b4-a720a84d946d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3976","original_object":"UniProtKB:P09483"}
{"id":"8a81b916-d748-447b-9a53-b98e12844dd1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:51913","predicate":"biolink:affects","object":"NCBIGene:5587","sources":[{"id":"urn:uuid:27ce90e2-b7dd-4437-a810-7201010e937e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5973","original_object":"UniProtKB:Q15139"}
{"id":"31d66040-2ee6-4261-a0ac-3ca19a29c27f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6123","predicate":"biolink:affects","object":"NCBIGene:6571","sources":[{"id":"urn:uuid:da88c894-52f9-4600-855e-2f49c4976e69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:88","original_object":"UniProtKB:Q05940"}
{"id":"adb53e56-63c7-4411-bc2d-f0408adbb653","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15551","predicate":"biolink:affects","object":"NCBIGene:25637","sources":[{"id":"urn:uuid:152b0102-fb47-4fa3-9d9c-6185ed35885a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1883","original_object":"UniProtKB:P70597"}
{"id":"ebb9c2ba-e335-42cc-8b6d-43f52ec61afc","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:10486131","predicate":"biolink:affects","object":"NCBIGene:4986","sources":[{"id":"urn:uuid:775ad80a-3322-47a4-a142-486c9b091a86","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1621","original_object":"UniProtKB:P41145"}
{"id":"cab3fc73-54eb-4e28-a189-5f183cc4ab08","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:131347","predicate":"biolink:affects","object":"NCBIGene:778","sources":[{"id":"urn:uuid:1fed7b06-d01c-4e86-a582-46e580ef492d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4065","original_object":"UniProtKB:O60840"}
{"id":"7cb4963b-46d9-496a-97d4-6d56300beae6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:233412","predicate":"biolink:affects","object":"NCBIGene:1901","sources":[{"id":"urn:uuid:7b1e1b63-dae7-4ad8-86b5-ea945fe9470b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9320","original_object":"UniProtKB:P21453"}
{"id":"6916adb6-0939-4f1a-a370-403128ee3173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4463007","predicate":"biolink:affects","object":"NCBIGene:3718","sources":[{"id":"urn:uuid:fc5c94fa-0230-4c96-9cc3-4785dd2c9530","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10527","original_object":"UniProtKB:P52333"}
{"id":"72d4947d-a909-4fd4-b89c-46182853340f","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:50942314","predicate":"biolink:affects","object":"NCBIGene:23012","sources":[{"id":"urn:uuid:9ef559ef-4a03-4c11-b720-09b3d5efe9c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8210","original_object":"UniProtKB:Q9Y2H1"}
{"id":"ea8ded87-1d93-4ff2-9f89-458524a11616","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:65209","predicate":"biolink:affects","object":"NCBIGene:5156","sources":[{"id":"urn:uuid:8cd506f4-3bae-4ee3-a82e-48475be75fa9","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7649","original_object":"UniProtKB:P16234"}
{"id":"335561e0-0010-4ddc-9874-218054c95fa0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64203","predicate":"biolink:affects","object":"NCBIGene:3355","sources":[{"id":"urn:uuid:13c0e046-d15c-4c00-b0c8-701009dab797","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:89","original_object":"UniProtKB:P30939"}
{"id":"eba5b68d-3637-4ceb-93e0-d8ddb05b10f9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:48562","predicate":"biolink:affects","object":"NCBIGene:152","sources":[{"id":"urn:uuid:77883172-dcf7-4638-8267-62d71873c149","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:136","original_object":"UniProtKB:P18825"}
{"id":"677ec764-4dc8-4893-b40c-a9f18b900a90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:221382","predicate":"biolink:affects","object":"NCBIGene:1991","sources":[{"id":"urn:uuid:ab193038-73de-49fa-b85a-b32a4717bdda","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10967","original_object":"UniProtKB:P08246"}
{"id":"79165be2-a32d-44dd-862d-bfdc1cace808","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9122","predicate":"biolink:affects","object":"NCBIGene:1814","sources":[{"id":"urn:uuid:7824db77-99b7-4121-a1a1-5f109048cd58","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:98","original_object":"UniProtKB:P35462"}
{"id":"a4c751ef-bdfe-48b3-801d-4f9f2d241ef6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEMBL.COMPOUND:CHEMBL4249798","predicate":"biolink:affects","object":"NCBIGene:1234","sources":[{"id":"urn:uuid:e45f4cd1-062a-4cbb-9cb1-a7d40004631e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10106","original_object":"UniProtKB:P51681"}
{"id":"44725f7c-e318-4208-b76c-1051b95d62d8","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:57369426","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:b0fd6bf7-8acc-4dc7-842f-f3937a8a370a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5560","original_object":"UniProtKB:Q9Y2T6"}
{"id":"ab3b5f10-8764-4fcc-98f2-36110d9e6a16","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:4615193","predicate":"biolink:affects","object":"NCBIGene:2893","sources":[{"id":"urn:uuid:83187881-14bf-4dc4-906a-2248e9cdec05","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4141","original_object":"UniProtKB:P48058"}
{"id":"3bf3cae9-7226-4f84-ac15-e476fde0e2a1","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2041","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:50118516-9331-4c6d-9a9f-59d317bd911c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2041","original_object":"UniProtKB:P30874"}
{"id":"b621d00e-4826-47be-94b8-948eb53eee1b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:I5YE3I47D8","predicate":"biolink:affects","object":"NCBIGene:55503","sources":[{"id":"urn:uuid:a8a12370-edb5-46fc-9790-dd0a1bf165df","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6418","original_object":"UniProtKB:Q9H1D0"}
{"id":"89a07ee0-d732-4cb2-b37d-453db7cf7164","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:3842","predicate":"biolink:affects","object":"NCBIGene:7434","sources":[{"id":"urn:uuid:d8da2dbe-7d03-43ca-92ed-ed35c545dda8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3842","original_object":"UniProtKB:P41587"}
{"id":"2f81a872-0066-458f-9bb9-5fbd467b0db0","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:5642","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:be7c303b-0288-4e5e-912f-cea2b4fd7a2f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5642","original_object":"UniProtKB:P30874"}
{"id":"7c1d0d5c-f3c4-407d-b4d4-d8705806b63e","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:44303431","predicate":"biolink:affects","object":"NCBIGene:25675","sources":[{"id":"urn:uuid:2643b39c-fa79-4045-a633-8b1687b153f8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3020","original_object":"UniProtKB:P51639"}
{"id":"837ffe85-3ac6-4748-a651-7f719c8ac92a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:TQ6PBX1JU0","predicate":"biolink:affects","object":"NCBIGene:695","sources":[{"id":"urn:uuid:d6149bb0-67ce-48b1-8584-93342f8b6955","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11671","original_object":"UniProtKB:Q06187"}
{"id":"a1e30852-8e02-4355-8fa1-5e1d9c814156","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:27974","predicate":"biolink:affects","object":"NCBIGene:2100","sources":[{"id":"urn:uuid:c840b829-31b8-4655-b88c-848f4a84b353","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2821","original_object":"UniProtKB:Q92731"}
{"id":"d06d9465-3dba-42dd-8884-672eeb802b25","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9848160","predicate":"biolink:affects","object":"NCBIGene:29665","sources":[{"id":"urn:uuid:f731598f-1da2-4026-8bfe-0d6402a72d64","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"positive_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9022","original_object":"UniProtKB:Q64663"}
{"id":"5ebd1d4e-0b8a-4ecf-b69a-9ef1bd5cfc9b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:71311710","predicate":"biolink:affects","object":"NCBIGene:56923","sources":[{"id":"urn:uuid:4a5a2018-daff-4b2e-a5ea-a51a6e36dd3f","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1475","original_object":"UniProtKB:Q9GZQ4"}
{"id":"2cffa23a-19f0-4c61-8922-4a6929363085","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:9737","predicate":"biolink:affects","object":"NCBIGene:1719","sources":[{"id":"urn:uuid:0b927fb8-4c29-437c-8298-3d07b791f67d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7613","original_object":"UniProtKB:P00374"}
{"id":"c3611aae-16de-4592-94d2-6cc6cb839407","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:73755020","predicate":"biolink:affects","object":"NCBIGene:19204","sources":[{"id":"urn:uuid:bec1bb68-2133-4b0c-9c0d-867a2afa914b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1846","original_object":"UniProtKB:Q62035"}
{"id":"c8cf9467-2583-46d9-a376-914fc47f2859","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:122227","predicate":"biolink:affects","object":"NCBIGene:623","sources":[{"id":"urn:uuid:060d32da-3f96-4631-9a01-491d1d8c8c5d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:644","original_object":"UniProtKB:P46663"}
{"id":"ba0ed05f-a7ac-41ef-9c56-f1a6da44c360","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:9794218","predicate":"biolink:affects","object":"NCBIGene:2915","sources":[{"id":"urn:uuid:6f1a1d11-957f-42d6-a830-6f4fd74c9ef5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"mixed_allosteric_modulation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:3336","original_object":"UniProtKB:P41594"}
{"id":"13227f90-fef8-447a-b759-a4e50a4b6ecd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:8481","predicate":"biolink:affects","object":"NCBIGene:1131","sources":[{"id":"urn:uuid:ee24f3b1-d5d2-4905-b4b5-4dc12e7e7215","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:329","original_object":"UniProtKB:P20309"}
{"id":"f38d32a8-94f5-4b40-ab27-49c391de74db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:2111037","predicate":"biolink:affects","object":"NCBIGene:57192","sources":[{"id":"urn:uuid:959a63ba-cf3f-4f6e-94a6-f7c8c3fc2c38","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6389","original_object":"UniProtKB:Q9GZU1"}
{"id":"3fc85b81-9ea7-4abf-8228-54ed576a5641","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:11753159","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:8f492e22-3a92-4110-aa46-67d833e2f558","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"molecular_channel_blockage","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:7679","original_object":"UniProtKB:Q12809"}
{"id":"a8a9fbc6-4bb3-427f-9d3e-7e427de4ac90","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:379896","predicate":"biolink:affects","object":"NCBIGene:367","sources":[{"id":"urn:uuid:a2ec554a-79a2-4ab1-87f0-831ac897868b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2857","original_object":"UniProtKB:P10275"}
{"id":"e396222b-48c6-447f-8f68-64fb898a2f76","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:6LGR0RYY5Q","predicate":"biolink:affects","object":"NCBIGene:23097","sources":[{"id":"urn:uuid:f16816f3-71da-4949-a4f4-dac892b9a165","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13753","original_object":"UniProtKB:Q9BWU1"}
{"id":"146fff90-dd34-4c4f-8ee9-2da9d8b24d6d","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:92180","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:c0834142-922f-49f5-be96-a1d2e5dc3600","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5620","original_object":"UniProtKB:P30543"}
{"id":"6866ea70-6be4-489e-8440-8e81e3ec33ea","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:64216","predicate":"biolink:affects","object":"NCBIGene:29581","sources":[{"id":"urn:uuid:1376f641-1e7d-430a-8b85-f2e48d9808e4","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:133","original_object":"UniProtKB:P30994"}
{"id":"f2f38d7e-c533-41b4-9312-acc92132bc40","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2529","predicate":"biolink:affects","object":"NCBIGene:25398","sources":[{"id":"urn:uuid:39c74687-93c5-486b-b587-db931b889c7b","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"gating_inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2529","original_object":"UniProtKB:P54282"}
{"id":"a974d88f-ff20-4b8e-970e-9a6f62ecc637","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1101","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:8dcd3b46-663a-4a22-a125-7028cd0ec21a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1101","original_object":"UniProtKB:Q92847"}
{"id":"8d5eced6-3f80-414c-a629-d0f106171ca3","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817388","predicate":"biolink:affects","object":"NCBIGene:2693","sources":[{"id":"urn:uuid:64a22ff8-5c41-4280-8dc5-451fa7d8b65c","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1095","original_object":"UniProtKB:Q92847"}
{"id":"a886b221-e5c5-4623-9938-e0d725ebb694","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:38937","predicate":"biolink:affects","object":"NCBIGene:1020","sources":[{"id":"urn:uuid:7a9c9e6b-0695-40bb-99e3-29a0f2feefdf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5927","original_object":"UniProtKB:Q00535"}
{"id":"72effc21-76fc-4de6-9a12-44cc375b95d4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:12966","predicate":"biolink:affects","object":"NCBIGene:1493","sources":[{"id":"urn:uuid:8bc5fabc-85f3-498d-b3ba-fc656a5a22f7","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"binding","original_subject":"GTOPDB:12966","original_object":"UniProtKB:P16410"}
{"id":"3d854751-9a97-4729-8ba4-b39d65ab5d50","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:114187","predicate":"biolink:affects","object":"NCBIGene:25601","sources":[{"id":"urn:uuid:5d90c542-e3e9-4325-b6d0-9de34f6016f1","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9002","original_object":"UniProtKB:P33535"}
{"id":"a0613fcd-ddfb-49c3-a227-f4923aa0530b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:50275","predicate":"biolink:affects","object":"NCBIGene:495","sources":[{"id":"urn:uuid:5c2537c3-3d7d-4444-8d2b-ee423e370715","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5488","original_object":"UniProtKB:P20648"}
{"id":"7861c771-d899-488a-9891-27ce41c799cb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:60138149","predicate":"biolink:affects","object":"NCBIGene:3984","sources":[{"id":"urn:uuid:c1c37df8-8f08-46da-816d-3f86a5c62151","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8152","original_object":"UniProtKB:P53667"}
{"id":"34c8ea31-6b64-4165-b509-d82af365c4b4","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:35847","predicate":"biolink:affects","object":"NCBIGene:3761","sources":[{"id":"urn:uuid:a95b0809-dfee-4d7a-9d76-1466914642bf","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2395","original_object":"UniProtKB:P48050"}
{"id":"be45480b-63f1-4bd3-9ed3-6f4a4bfff399","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:16015","predicate":"biolink:affects","object":"NCBIGene:24416","sources":[{"id":"urn:uuid:73ce166a-007a-438b-94fc-62bde50086c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1369","original_object":"UniProtKB:P31422"}
{"id":"31d9b79b-4f5b-4871-9124-c5891b7ca229","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:15811","predicate":"biolink:affects","object":"NCBIGene:2918","sources":[{"id":"urn:uuid:1c00993a-b0be-4cfc-9e12-f5cf9b8be051","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1411","original_object":"UniProtKB:O00222"}
{"id":"447055d6-91db-49ad-9ba2-0c6686997a52","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:6456","predicate":"biolink:affects","object":"NCBIGene:25665","sources":[{"id":"urn:uuid:c986e3bc-a0ec-4ca9-8d06-bbf26a6bf4c6","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","causal_mechanism_qualifier":"molecular_channel_blockage","original_subject":"GTOPDB:2623","original_object":"UniProtKB:P15389"}
{"id":"315eb6f1-d5b0-46cc-aed6-5fae52d2e3db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:230904","predicate":"biolink:affects","object":"NCBIGene:1812","sources":[{"id":"urn:uuid:45502442-a758-4dba-a758-4e31694cb329","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:932","original_object":"UniProtKB:P21728"}
{"id":"bec6a171-68bc-4521-85fc-7acd0b4a6b69","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:23Y783RURX","predicate":"biolink:affects","object":"NCBIGene:5468","sources":[{"id":"urn:uuid:43f5a78c-8230-4cc7-97ee-353c30cd1344","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2704","original_object":"UniProtKB:P37231"}
{"id":"8ab5794e-d3e7-4dfc-a64a-f3dca6b59094","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:O812716S9E","predicate":"biolink:affects","object":"NCBIGene:3062","sources":[{"id":"urn:uuid:c24ddf1f-fcf9-451e-8354-9148cda636d8","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:9306","original_object":"UniProtKB:O43614"}
{"id":"54d3a82a-9ce8-4b23-a4dd-631bceca27fb","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:70968BVH2J","predicate":"biolink:affects","object":"NCBIGene:3352","sources":[{"id":"urn:uuid:27ae2dc6-e319-4e62-a91a-76ef987d4403","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:39","original_object":"UniProtKB:P28221"}
{"id":"b6b4516f-0fbb-49c1-af86-ca366d2b78ae","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:139507438","predicate":"biolink:affects","object":"NCBIGene:9376","sources":[{"id":"urn:uuid:9f5540bc-0c04-4565-8670-5ab4c2a77d6a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13271","original_object":"UniProtKB:Q8TCC7"}
{"id":"f7da1f6a-7741-4ca8-9222-0defa8fee173","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118866105","predicate":"biolink:affects","object":"NCBIGene:23621","sources":[{"id":"urn:uuid:f5a74b63-9665-4f36-af91-93fc8a20f86a","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:10520","original_object":"UniProtKB:P56817"}
{"id":"52b55eb2-6dab-4c45-bc9b-f3c19d3b190b","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:197013","predicate":"biolink:affects","object":"NCBIGene:9290","sources":[{"id":"urn:uuid:6f7235dd-5973-4c1b-b130-04fbe7b22e20","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5526","original_object":"UniProtKB:Q9Y2T6"}
{"id":"8963a125-312b-4b39-93df-aa0344f0bd77","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:7689","predicate":"biolink:affects","object":"NCBIGene:3757","sources":[{"id":"urn:uuid:92094582-6072-44dc-b179-4df4bbdd02c2","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","original_subject":"GTOPDB:7689","original_object":"UniProtKB:Q12809"}
{"id":"d0e482df-48b1-468a-b9c3-ab8cf6012561","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817437","predicate":"biolink:affects","object":"NCBIGene:7433","sources":[{"id":"urn:uuid:6c253521-70d2-4e82-959a-9cb28620784d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2268","original_object":"UniProtKB:P32241"}
{"id":"9b093df6-38b9-4d0e-8c14-072b551209be","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1995","predicate":"biolink:affects","object":"NCBIGene:122042","sources":[{"id":"urn:uuid:8788f957-cffe-43c8-a76b-99e22aef48c5","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1995","original_object":"UniProtKB:Q8WXD0"}
{"id":"dab2feb4-55a0-4234-b21d-1e630b7b5287","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:24825377","predicate":"biolink:affects","object":"NCBIGene:247","sources":[{"id":"urn:uuid:7128353c-ea64-4cb8-997b-749d1a4b8773","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:8750","original_object":"UniProtKB:O15296"}
{"id":"3eef16af-9be8-420d-b991-0989532602bf","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:13863","predicate":"biolink:affects","object":"NCBIGene:259292","sources":[{"id":"urn:uuid:0eedbc55-8ea0-4f89-a417-0190b0b86dba","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:13863","original_object":"UniProtKB:P59540"}
{"id":"c581e5a3-2c6c-453c-adce-9698b3e868fa","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:118166566","predicate":"biolink:affects","object":"NCBIGene:4048","sources":[{"id":"urn:uuid:dbd1e302-1f98-42e3-9542-9d49473de497","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"inhibition","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:11205","original_object":"UniProtKB:P09960"}
{"id":"84485951-d63d-407b-90ee-4bcc2024c0bd","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:2042","predicate":"biolink:affects","object":"NCBIGene:6752","sources":[{"id":"urn:uuid:9daab5cf-73ce-400d-b88e-3f82892a4d69","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:2042","original_object":"UniProtKB:P30874"}
{"id":"93952d80-0888-4ca7-b727-e9ed671daad9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:155817490","predicate":"biolink:affects","object":"NCBIGene:4829","sources":[{"id":"urn:uuid:763f6105-4b7d-492d-8f5b-33bfc56780c0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:6168","original_object":"UniProtKB:P28336"}
{"id":"b8bd45cb-2628-4ce6-bf25-08786e354913","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"GTOPDB:1819","predicate":"biolink:affects","object":"NCBIGene:5746","sources":[{"id":"urn:uuid:9ca306c2-3a19-4b0b-9d53-37780edd7ea0","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1819","original_object":"UniProtKB:P49190"}
{"id":"a542c68b-2f11-4a92-8a12-973a6e95cca5","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"CHEBI:42797","predicate":"biolink:affects","object":"NCBIGene:3786","sources":[{"id":"urn:uuid:5ce4292a-b45d-4734-96b8-ab80af9cd539","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"activation","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:5483","original_object":"UniProtKB:O43525"}
{"id":"72ab18e1-dd9c-446d-8938-d8a8a272e5c9","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:9M18T0TD14","predicate":"biolink:affects","object":"NCBIGene:4988","sources":[{"id":"urn:uuid:058c1653-f11b-4e1d-8de4-c764f963870d","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:1620","original_object":"UniProtKB:P35372"}
{"id":"c0c76402-384c-4b17-8186-7624a829dd6a","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123884","predicate":"biolink:affects","object":"NCBIGene:12061","sources":[{"id":"urn:uuid:d119a5d8-7fe9-421a-b218-172f75292a31","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:641","original_object":"UniProtKB:Q61125"}
{"id":"88b32c34-86d0-4628-ab7f-09254c746482","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:E6BTT8VA5Z","predicate":"biolink:affects","object":"NCBIGene:230777","sources":[{"id":"urn:uuid:faccfbea-5cd1-4542-b4ca-f9b56c0622dd","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"decreased","causal_mechanism_qualifier":"antagonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:4460","original_object":"UniProtKB:P58307"}
{"id":"d4a6c6cf-115b-4a47-a559-bf2a018265d6","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"PUBCHEM.COMPOUND:123807","predicate":"biolink:affects","object":"NCBIGene:25369","sources":[{"id":"urn:uuid:22997c35-6c37-44e0-95e3-b014947ac446","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:374","original_object":"UniProtKB:P30543"}
{"id":"ef287d6e-a38b-44bb-9044-b6731e1869db","category":["biolink:ChemicalAffectsGeneAssociation"],"subject":"UNII:54Z8M50D6Q","predicate":"biolink:affects","object":"NCBIGene:1128","sources":[{"id":"urn:uuid:071e623a-d42a-4e68-8389-753b4f52a85e","category":["biolink:RetrievalSource"],"resource_id":"infores:gtopdb","resource_role":"primary_knowledge_source"}],"knowledge_level":"knowledge_assertion","agent_type":"manual_agent","object_aspect_qualifier":"activity","object_direction_qualifier":"increased","causal_mechanism_qualifier":"agonism","qualified_predicate":"biolink:causes","original_subject":"GTOPDB:298","original_object":"UniProtKB:P11229"}